Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP24241
DateThu Jan 5 11:41:33 GMT 2012
Unique Job ID92a625dc854ea0d0

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3qnqD_
Top template information
PDB header:membrane protein, transport protein
Chain: D: PDB Molecule:pts system, cellobiose-specific iic component;
PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system
Confidence and coverage
Confidence:100.0% Coverage: 79%
382 residues ( 79% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
Additional confident templates have been detected (see Domain analysis) which cover other regions of your sequence.
472 residues ( 97%) could be modelled at >90% confidence using multiple-templates.
You may wish to try resubmitting your sequence in "intensive" mode to model more of your sequence.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MAKNYAALARSVIAALGGVDNISAVTHCMTRLRFVIKDDALIDSPTLKTIPGVLGVVRSD
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   .........70.........80.........90.........100.........110.........120
Sequence  NQCQVIIGNTVSQAFQEVVSLLPGDMQPAQPVGKPKLTLRRIGAGILDALIGTMSPLIPA
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?
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   .........130.........140.........150.........160.........170.........180
Sequence  IIGGSMVKLLAMILEMSGVLTKGSPTLTILNVIGDGAFFFLPLMVAASAAIKFKTNMSLA
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   .........190.........200.........210.........220.........230.........240
Sequence  IAIAGVLVHPSFIELMAKAAQGEHVEFALIPVTAVKYTYTVIPALVMTWCLSYIERWVDS
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   .........250.........260.........270.........280.........290.........300
Sequence  ITPAVTKNFLKPMLIVLIAAPLAILLIGPIGIWIGSAISALVYTIHGYLGWLSVAIMGAL
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   .........310.........320.........330.........340.........350.........360
Sequence  WPLLVMTGMHRVFTPTIIQTIAETGKEGMVMPSEIGANLSLGGSSLAVAWKTKNPELRQT
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?
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   .........370.........380.........390.........400.........410.........420
Sequence  ALAAAASAIMAGISEPALYGVAIRLKRPLIASLISGFICGAVAGMAGLASHSMAAPGLFT
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   .........430.........440.........450.........460.........470.........480
Sequence  SVQFFDPANPMSIVWVFAVMALAVVLSFILTLLLGFEDIPVEEAAAQARKYQSVQPTVAK
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   .....
Sequence  EVSLN
Secondary structure 




SS confidence 




Disorder  ?????
Disorder confidence 




 

Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3qnq chain D

3D model

Region: 92 - 475
Aligned: 382
Modelled: 384
Confidence: 100.0%
Identity: 14%
PDB header:membrane protein, transport protein
Chain: D: PDB Molecule:pts system, cellobiose-specific iic component;
PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system

Phyre2

PDB 3ipj chain B

3D model

Region: 2 - 94
Aligned: 92
Modelled: 93
Confidence: 100.0%
Identity: 28%
PDB header:transferase
Chain: B: PDB Molecule:pts system, iiabc component;
PDBTitle: the crystal structure of one domain of the pts system, iiabc component2 from clostridium difficile

Phyre2

PDB 1iba chain A

3D model

Region: 8 - 82
Aligned: 74
Modelled: 75
Confidence: 99.9%
Identity: 32%
PDB header:phoshphotransferase
Chain: A: PDB Molecule:glucose permease;
PDBTitle: glucose permease (domain iib), nmr, 11 structures

Phyre2

PDB 3bp8 chain C domain 1

3D model

Region: 8 - 82
Aligned: 74
Modelled: 75
Confidence: 99.9%
Identity: 32%
Fold: Homing endonuclease-like
Superfamily: Glucose permease domain IIB
Family: Glucose permease domain IIB

Phyre2

PDB 3sy6 chain A

3D model

Region: 27 - 50
Aligned: 24
Modelled: 24
Confidence: 46.3%
Identity: 25%
PDB header:cell adhesion
Chain: A: PDB Molecule:fimbrial protein bf1861;
PDBTitle: crystal structure of a fimbrial protein bf1861 [bacteroides fragilis2 nctc 9343] (bf1861) from bacteroides fragilis nctc 9343 at 1.90 a3 resolution

Phyre2

PDB 2knc chain A

3D model

Region: 433 - 469
Aligned: 37
Modelled: 37
Confidence: 42.4%
Identity: 19%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Phyre2

PDB 3t2l chain A

3D model

Region: 27 - 50
Aligned: 24
Modelled: 24
Confidence: 39.0%
Identity: 13%
PDB header:cell adhesion
Chain: A: PDB Molecule:putative cell adhesion protein;
PDBTitle: crystal structure of a putative cell adhesion protein (bf1858) from2 bacteroides fragilis nctc 9343 at 2.33 a resolution

Phyre2

PDB 2jan chain D

3D model

Region: 6 - 48
Aligned: 42
Modelled: 43
Confidence: 34.8%
Identity: 29%
PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state

Phyre2

PDB 1i1g chain A domain 2

3D model

Region: 26 - 67
Aligned: 41
Modelled: 42
Confidence: 19.7%
Identity: 12%
Fold: Ferredoxin-like
Superfamily: Dimeric alpha+beta barrel
Family: Lrp/AsnC-like transcriptional regulator C-terminal domain

Phyre2

PDB 2bbj chain B

3D model

Region: 418 - 458
Aligned: 41
Modelled: 41
Confidence: 15.7%
Identity: 20%
PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter

Phyre2

PDB 2hqn chain A

3D model

Region: 10 - 53
Aligned: 42
Modelled: 44
Confidence: 15.4%
Identity: 12%
PDB header:signaling protein
Chain: A: PDB Molecule:putative transcriptional regulator;
PDBTitle: structure of a atypical orphan response regulator protein revealed a2 new phosphorylation-independent regulatory mechanism

Phyre2

PDB 1ffg chain B

3D model

Region: 44 - 73
Aligned: 30
Modelled: 30
Confidence: 14.7%
Identity: 13%
Fold: Ferredoxin-like
Superfamily: CheY-binding domain of CheA
Family: CheY-binding domain of CheA

Phyre2

PDB 2wsh chain C

3D model

Region: 33 - 63
Aligned: 31
Modelled: 31
Confidence: 14.5%
Identity: 10%
PDB header:hydrolase
Chain: C: PDB Molecule:endonuclease ii;
PDBTitle: structure of bacteriophage t4 endoii e118a mutant

Phyre2

PDB 1a0o chain H

3D model

Region: 44 - 73
Aligned: 30
Modelled: 30
Confidence: 14.1%
Identity: 13%
PDB header:chemotaxis
Chain: H: PDB Molecule:chea;
PDBTitle: chey-binding domain of chea in complex with chey

Phyre2

PDB 2pmu chain D

3D model

Region: 5 - 53
Aligned: 43
Modelled: 49
Confidence: 13.6%
Identity: 21%
PDB header:transcription regulation
Chain: D: PDB Molecule:response regulator phop;
PDBTitle: crystal structure of the dna-binding domain of phop

Phyre2

PDB 1vgg chain A

3D model

Region: 57 - 83
Aligned: 27
Modelled: 27
Confidence: 13.5%
Identity: 26%
Fold: Ta1353-like
Superfamily: Ta1353-like
Family: Ta1353-like

Phyre2

PDB 2xv4 chain S

3D model

Region: 4 - 34
Aligned: 26
Modelled: 26
Confidence: 13.3%
Identity: 19%
PDB header:transcription
Chain: S: PDB Molecule:dna-directed rna polymerase iii subunit rpc3;
PDBTitle: structure of human rpc62 (partial)

Phyre2

PDB 1gxq chain A

3D model

Region: 10 - 53
Aligned: 42
Modelled: 44
Confidence: 12.8%
Identity: 17%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: C-terminal effector domain of the bipartite response regulators
Family: PhoB-like

Phyre2

PDB 1ciy chain A domain 1

3D model

Region: 39 - 70
Aligned: 31
Modelled: 32
Confidence: 12.7%
Identity: 19%
Fold: Galactose-binding domain-like
Superfamily: Galactose-binding domain-like
Family: delta-Endotoxin, C-terminal domain

Phyre2

PDB 1kgs chain A domain 1

3D model

Region: 10 - 53
Aligned: 40
Modelled: 44
Confidence: 12.6%
Identity: 13%
Fold: DNA/RNA-binding 3-helical bundle
Superfamily: C-terminal effector domain of the bipartite response regulators
Family: PhoB-like

Phyre2
1

c3qnqD_
2

c3ipjB_
3

c1ibaA_
4

d3bp8c1
5

c3sy6A_
6

c2kncA_
7

c3t2lA_
8

c2janD_
9

d1i1ga2
10

c2bbjB_
11

c2hqnA_
12

d1ffgb_
13

c2wshC_
14

c1a0oH_
15

c2pmuD_
16

d1vgga_
17

c2xv4S_
18

d1gxqa_
19

d1ciya1
20

d1kgsa1
21



22



23



24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



39



40



41



42



43



44



45



46



47



48



49



50



51



52



53



54



55



56



57



58






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3qnqD_



100.0 14 PDB header:membrane protein, transport protein
Chain: D: PDB Molecule:pts system, cellobiose-specific iic component;
PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system
2c3ipjB_



100.0 28 PDB header:transferase
Chain: B: PDB Molecule:pts system, iiabc component;
PDBTitle: the crystal structure of one domain of the pts system, iiabc component2 from clostridium difficile
3c1ibaA_



99.9 32 PDB header:phoshphotransferase
Chain: A: PDB Molecule:glucose permease;
PDBTitle: glucose permease (domain iib), nmr, 11 structures
4d3bp8c1



99.9 32 Fold:Homing endonuclease-like
Superfamily:Glucose permease domain IIB
Family:Glucose permease domain IIB
5c3sy6A_



46.3 25 PDB header:cell adhesion
Chain: A: PDB Molecule:fimbrial protein bf1861;
PDBTitle: crystal structure of a fimbrial protein bf1861 [bacteroides fragilis2 nctc 9343] (bf1861) from bacteroides fragilis nctc 9343 at 1.90 a3 resolution
6c2kncA_



42.4 19 PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex
7c3t2lA_



39.0 13 PDB header:cell adhesion
Chain: A: PDB Molecule:putative cell adhesion protein;
PDBTitle: crystal structure of a putative cell adhesion protein (bf1858) from2 bacteroides fragilis nctc 9343 at 2.33 a resolution
8c2janD_



34.8 29 PDB header:ligase
Chain: D: PDB Molecule:tyrosyl-trna synthetase;
PDBTitle: tyrosyl-trna synthetase from mycobacterium tuberculosis in2 unliganded state
9d1i1ga2



19.7 12 Fold:Ferredoxin-like
Superfamily:Dimeric alpha+beta barrel
Family:Lrp/AsnC-like transcriptional regulator C-terminal domain
10c2bbjB_



15.7 20 PDB header:metal transport/membrane protein
Chain: B: PDB Molecule:divalent cation transport-related protein;
PDBTitle: crystal structure of the cora mg2+ transporter
11c2hqnA_



15.4 12 PDB header:signaling protein
Chain: A: PDB Molecule:putative transcriptional regulator;
PDBTitle: structure of a atypical orphan response regulator protein revealed a2 new phosphorylation-independent regulatory mechanism
12d1ffgb_



14.7 13 Fold:Ferredoxin-like
Superfamily:CheY-binding domain of CheA
Family:CheY-binding domain of CheA
13c2wshC_



14.5 10 PDB header:hydrolase
Chain: C: PDB Molecule:endonuclease ii;
PDBTitle: structure of bacteriophage t4 endoii e118a mutant
14c1a0oH_



14.1 13 PDB header:chemotaxis
Chain: H: PDB Molecule:chea;
PDBTitle: chey-binding domain of chea in complex with chey
15c2pmuD_



13.6 21 PDB header:transcription regulation
Chain: D: PDB Molecule:response regulator phop;
PDBTitle: crystal structure of the dna-binding domain of phop
16d1vgga_



13.5 26 Fold:Ta1353-like
Superfamily:Ta1353-like
Family:Ta1353-like
17c2xv4S_



13.3 19 PDB header:transcription
Chain: S: PDB Molecule:dna-directed rna polymerase iii subunit rpc3;
PDBTitle: structure of human rpc62 (partial)
18d1gxqa_



12.8 17 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:C-terminal effector domain of the bipartite response regulators
Family:PhoB-like
19d1ciya1



12.7 19 Fold:Galactose-binding domain-like
Superfamily:Galactose-binding domain-like
Family:delta-Endotoxin, C-terminal domain
20d1kgsa1



12.6 13 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:C-terminal effector domain of the bipartite response regulators
Family:PhoB-like
21c2oarA_



not modelled 11.7 6 PDB header:membrane protein
Chain: A: PDB Molecule:large-conductance mechanosensitive channel;
PDBTitle: mechanosensitive channel of large conductance (mscl)
22c1vbkA_



not modelled 10.4 12 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:hypothetical protein ph1313;
PDBTitle: crystal structure of ph1313 from pyrococcus horikoshii ot3
23d2bgwa1



not modelled 10.3 13 Fold:SAM domain-like
Superfamily:RuvA domain 2-like
Family:Hef domain-like
24d1ji6a1



not modelled 10.3 23 Fold:Galactose-binding domain-like
Superfamily:Galactose-binding domain-like
Family:delta-Endotoxin, C-terminal domain
25d1wlqc_



not modelled 9.3 13 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:"Winged helix" DNA-binding domain
Family:DNA replication factor Cdt1
26c3ufiA_



not modelled 9.1 17 PDB header:cell adhesion
Chain: A: PDB Molecule:hypothetical protein bacova_04980;
PDBTitle: crystal structure of a hypothetical protein2 bacova_04980(zp_02067969.1) from bacteroides ovatus atcc 8483 at 2.183 a resolution
27c1p68A_



not modelled 9.1 30 PDB header:de novo protein
Chain: A: PDB Molecule:de novo designed protein s-824;
PDBTitle: solution structure of s-824, a de novo designed four helix2 bundle
28c2ekmC_



not modelled 8.0 33 PDB header:structural genomics, unknown function
Chain: C: PDB Molecule:hypothetical protein st1511;
PDBTitle: structure of st1219 protein from sulfolobus tokodaii
29c2voyB_



not modelled 8.0 6 PDB header:hydrolase
Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium
PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus
30d2oara1



not modelled 7.9 10 Fold:Gated mechanosensitive channel
Superfamily:Gated mechanosensitive channel
Family:Gated mechanosensitive channel
31c1m6yA_



not modelled 7.7 20 PDB header:transferase
Chain: A: PDB Molecule:s-adenosyl-methyltransferase mraw;
PDBTitle: crystal structure analysis of tm0872, a putative sam-2 dependent methyltransferase, complexed with sah
32d2cfua2



not modelled 7.7 16 Fold:Metallo-hydrolase/oxidoreductase
Superfamily:Metallo-hydrolase/oxidoreductase
Family:Alkylsulfatase-like
33c2ht2B_



not modelled 7.6 11 PDB header:membrane protein
Chain: B: PDB Molecule:h(+)/cl(-) exchange transporter clca;
PDBTitle: structure of the escherichia coli clc chloride channel2 y445h mutant and fab complex
34d1ngka_



not modelled 7.3 26 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
35c2gl0A_



not modelled 7.3 33 PDB header:transferase
Chain: A: PDB Molecule:conserved hypothetical protein;
PDBTitle: structure of pae2307 in complex with adenosine
36c3ksiA_



not modelled 7.1 20 PDB header:oxidoreductase
Chain: A: PDB Molecule:putative uncharacterized protein;
PDBTitle: structure of frmsr of staphylococcus aureus (complex with 2-propanol)
37c2d16B_



not modelled 7.0 26 PDB header:structural genomics, unknown function
Chain: B: PDB Molecule:hypothetical protein ph1918;
PDBTitle: crystal structure of ph1918 protein from pyrococcus horikoshii ot3
38c2djwF_



not modelled 7.0 13 PDB header:unknown function
Chain: F: PDB Molecule:probable transcriptional regulator, asnc family;
PDBTitle: crystal structure of ttha0845 from thermus thermophilus hb8
39c2cfuA_



not modelled 6.6 16 PDB header:hydrolase
Chain: A: PDB Molecule:sdsa1;
PDBTitle: crystal structure of sdsa1, an alkylsulfatase from2 pseudomonas aeruginosa, in complex with 1-decane-sulfonic-3 acid.
40c2jzyA_



not modelled 6.3 19 PDB header:transcription
Chain: A: PDB Molecule:transcriptional regulatory protein pcor;
PDBTitle: solution structure of c-terminal effector domain of2 putative two-component-system response regulator involved3 in copper resistance from klebsiella pneumoniae
41c1oy8A_



not modelled 6.2 21 PDB header:membrane protein
Chain: A: PDB Molecule:acriflavine resistance protein b;
PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump
42c2ketA_



not modelled 6.2 29 PDB header:antibiotic
Chain: A: PDB Molecule:cathelicidin-6;
PDBTitle: solution structure of bmap-27
43c1lkzB_



not modelled 6.1 26 PDB header:isomerase
Chain: B: PDB Molecule:ribose 5-phosphate isomerase a;
PDBTitle: crystal structure of d-ribose-5-phosphate isomerase (rpia)2 from escherichia coli.
44c1dlcA_



not modelled 6.0 21 PDB header:toxin
Chain: A: PDB Molecule:delta-endotoxin cryiiia;
PDBTitle: crystal structure of insecticidal delta-endotoxin from2 bacillus thuringiensis at 2.5 angstroms resolution
45d1fzda_



not modelled 6.0 30 Fold:Fibrinogen C-terminal domain-like
Superfamily:Fibrinogen C-terminal domain-like
Family:Fibrinogen C-terminal domain-like
46c2kscA_



not modelled 6.0 19 PDB header:unknown function
Chain: A: PDB Molecule:cyanoglobin;
PDBTitle: solution structure of synechococcus sp. pcc 7002 hemoglobin
47c3ibwA_



not modelled 5.9 26 PDB header:transferase
Chain: A: PDB Molecule:gtp pyrophosphokinase;
PDBTitle: crystal structure of the act domain from gtp2 pyrophosphokinase of chlorobium tepidum. northeast3 structural genomics consortium target ctr148a
48c3aq8A_



not modelled 5.8 22 PDB header:oxygen binding
Chain: A: PDB Molecule:group 1 truncated hemoglobin;
PDBTitle: crystal structure of truncated hemoglobin from tetrahymena pyriformis,2 q46e mutant, fe(iii) form
49d2cfxa2



not modelled 5.7 13 Fold:Ferredoxin-like
Superfamily:Dimeric alpha+beta barrel
Family:Lrp/AsnC-like transcriptional regulator C-terminal domain
50c3k8hA_



not modelled 5.5 14 PDB header:membrane protein
Chain: A: PDB Molecule:30klp;
PDBTitle: structure of crystal form i of tp0453
51d2cg4a2



not modelled 5.5 13 Fold:Ferredoxin-like
Superfamily:Dimeric alpha+beta barrel
Family:Lrp/AsnC-like transcriptional regulator C-terminal domain
52d1vbka2



not modelled 5.5 12 Fold:THUMP domain
Superfamily:THUMP domain-like
Family:THUMP domain
53d1p2fa1



not modelled 5.5 24 Fold:DNA/RNA-binding 3-helical bundle
Superfamily:C-terminal effector domain of the bipartite response regulators
Family:PhoB-like
54d1s69a_



not modelled 5.3 19 Fold:Globin-like
Superfamily:Globin-like
Family:Truncated hemoglobin
55c2j61B_



not modelled 5.3 39 PDB header:lectin
Chain: B: PDB Molecule:ficolin-2;
PDBTitle: l-ficolin complexed to n-acetylglucosamine (forme c)
56d1m1jc1



not modelled 5.1 30 Fold:Fibrinogen C-terminal domain-like
Superfamily:Fibrinogen C-terminal domain-like
Family:Fibrinogen C-terminal domain-like
57d1x0pa1



not modelled 5.1 21 Fold:Ferredoxin-like
Superfamily:Acylphosphatase/BLUF domain-like
Family:BLUF domain
58d1lwub1



not modelled 5.1 22 Fold:Fibrinogen C-terminal domain-like
Superfamily:Fibrinogen C-terminal domain-like
Family:Fibrinogen C-terminal domain-like

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0