Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	H	Q	L	R	S	R	D	I	I	A	L	G	F	M	T	F	A	L	F	V	G	A	G	N	I	I	F	P	P	M	V	G	L	Q	A	G	E	H	V	W	T	A	A	F	G	F	L	I	T	A	V	G	L	P	V	L	T	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	L	A	K	V	G	G	G	V	D	S	L	S	T	P	I	G	K	V	A	G	V	L	L	A	T	V	C	Y	L	A	V	G	P	L	F	A	T	P	R	T	A	T	V	S	F	E	V	G	I	A	P	L	T	G	D	S	A	L
Secondary structure
SS confidence
Disorder																																																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	L	F	I	Y	S	L	V	Y	F	A	I	V	I	L	V	S	L	Y	P	G	K	L	L	D	T	V	G	N	F	L	A	P	L	K	I	I	A	L	V	I	L	S	V	A	A	I	V	W	P	A	G	S	I	S	T	A	T	E	A
Secondary structure
SS confidence
Disorder																																																	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		Y	Q	N	A	A	F	S	N	G	F	V	N	G	Y	L	T	M	D	T	L	G	A	M	V	F	G	I	V	I	V	N	A	A	R	S	R	G	V	T	E	A	R	L	L	T	R	Y	T	V	W	A	G	L	M	A	G	V	G	L	T
Secondary structure
SS confidence
Disorder																																					?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	L	Y	L	A	L	F	R	L	G	S	D	S	A	S	L	V	D	Q	S	A	N	G	A	A	I	L	H	A	Y	V	Q	H	T	F	G	G	G	G	S	F	L	L	A	A	L	I	F	I	A	C	L	V	T	A	V	G	L	T	C
Secondary structure
SS confidence
Disorder															?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	C	A	E	F	F	A	Q	Y	V	P	L	S	Y	R	T	L	V	F	I	L	G	G	F	S	M	V	V	S	N	L	G	L	S	Q	L	I	Q	I	S	V	P	V	L	T	A	I	Y	P	P	C	I	A	L	V	V	L	S	F	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		R	S	W	W	H	N	S	S	R	V	I	A	P	P	M	F	I	S	L	L	F	G	I	L	D	G	I	K	A	S	A	F	S	D	I	L	P	S	W	A	Q	R	L	P	L	A	E	Q	G	L	A	W	L	M	P	T	V	V	M	V
Secondary structure
SS confidence
Disorder																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.
Sequence		V	L	A	I	I	W	D	R	A	A	G	R	Q	V	T	S	S	A	H
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3gia chain A Region: 2 - 438 Aligned: 406 Modelled: 406 Confidence: 99.9% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 2jln chain A Region: 2 - 438 Aligned: 422 Modelled: 426 Confidence: 99.9% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 3lrc chain C Region: 2 - 435 Aligned: 385 Modelled: 385 Confidence: 99.8% Identity: 15% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 2xq2 chain A Region: 11 - 439 Aligned: 412 Modelled: 412 Confidence: 99.7% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 3dh4 chain A Region: 11 - 437 Aligned: 405 Modelled: 405 Confidence: 99.4% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2a65 chain A domain 1 Region: 6 - 437 Aligned: 429 Modelled: 429 Confidence: 98.1% Identity: 13% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 3hfx chain A Region: 15 - 368 Aligned: 350 Modelled: 350 Confidence: 91.1% Identity: 16% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 2w8a chain C Region: 75 - 369 Aligned: 292 Modelled: 295 Confidence: 91.0% Identity: 9% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 2iub chain A domain 2 Region: 408 - 432 Aligned: 25 Modelled: 25 Confidence: 6.4% Identity: 4% Fold: Transmembrane helix hairpin Superfamily: Magnesium transport protein CorA, transmembrane region Family: Magnesium transport protein CorA, transmembrane region Phyre2 PDB 2imu chain A Region: 331 - 354 Aligned: 24 Modelled: 24 Confidence: 6.1% Identity: 42% PDB header:viral protein Chain: A: PDB Molecule:structural polyprotein (pp) p1; PDBTitle: nmr structure of pep46 from the infectious bursal disease2 virus (ibdv) in dodecylphosphocholin (dpc). Phyre2 1 c3giaA_ 2 c2jlnA_ 3 c3lrcC_ 4 c2xq2A_ 5 c3dh4A_ 6 d2a65a1 7 c3hfxA_ 8 c2w8aC_ 9 d2iuba2 10 c2imuA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3giaA_ 99.9 13 PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter 2 c2jlnA_ 99.9 12 PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter 3 c3lrcC_ 99.8 15 PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) 4 c2xq2A_ 99.7 14 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 5 c3dh4A_ 99.4 14 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus 6 d2a65a1 98.1 13 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 7 c3hfxA_ 91.1 16 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter 8 c2w8aC_ 91.0 9 PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate 9 d2iuba2 6.4 4 Fold:Transmembrane helix hairpin Superfamily:Magnesium transport protein CorA, transmembrane region Family:Magnesium transport protein CorA, transmembrane region 10 c2imuA_ 6.1 42 PDB header:viral protein Chain: A: PDB Molecule:structural polyprotein (pp) p1; PDBTitle: nmr structure of pep46 from the infectious bursal disease2 virus (ibdv) in dodecylphosphocholin (dpc).

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0