Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	I	A	P	G	M	I	L	I	A	Y	L	C	G	S	I	S	S	A	I	L	V	C	R	L	C	G	L	P	D	P	R	T	S	G	S	G	N	P	G	A	T	N	V	L	R	I	G	G	K	G	A	A	V	A	V	L	I
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	D	V	L	K	G	M	L	P	V	W	G	A	Y	E	L	G	V	S	P	F	W	L	G	L	I	A	I	A	A	C	L	G	H	I	W	P	V	F	F	G	F	K	G	G	K	G	V	A	T	A	F	G	A	I	A	P	I	G	W
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	L	T	G	V	M	A	G	T	W	L	L	T	V	L	L	S	G	Y	S	S	L	G	A	I	V	S	A	L	I	A	P	F	Y	V	W	W	F	K	P	Q	F	T	F	P	V	S	M	L	S	C	L	I	L	L	R	H	H	D	N
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.
Sequence		I	Q	R	L	W	R	R	Q	E	T	K	I	W	T	K	F	K	R	K	R	E	K	D	P	E
Secondary structure
SS confidence
Disorder											?			?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2p3x chain A Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 15.0% Identity: 46% PDB header:oxidoreductase Chain: A: PDB Molecule:polyphenol oxidase, chloroplast; PDBTitle: crystal structure of grenache (vitis vinifera) polyphenol2 oxidase Phyre2 PDB 1bt3 chain A Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 14.1% Identity: 38% Fold: Di-copper centre-containing domain Superfamily: Di-copper centre-containing domain Family: Catechol oxidase Phyre2 PDB 2knc chain A Region: 152 - 205 Aligned: 39 Modelled: 39 Confidence: 12.6% Identity: 10% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 3npy chain B Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 11.0% Identity: 38% PDB header:oxidoreductase Chain: B: PDB Molecule:tyrosinase; PDBTitle: crystal structure of tyrosinase from bacillus megaterium soaked in2 cuso4 Phyre2 PDB 3qnq chain D Region: 191 - 205 Aligned: 15 Modelled: 15 Confidence: 10.6% Identity: 47% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 2y9x chain C Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 10.1% Identity: 46% PDB header:oxidoreductase Chain: C: PDB Molecule:polyphenol oxidase; PDBTitle: crystal structure of ppo3, a tyrosinase from agaricus bisporus, in2 deoxy-form that contains additional unknown lectin-like subunit,3 with inhibitor tropolone Phyre2 PDB 3lk2 chain B Region: 177 - 192 Aligned: 16 Modelled: 16 Confidence: 9.4% Identity: 50% PDB header:protein binding Chain: B: PDB Molecule:f-actin-capping protein subunit beta isoforms 1 and 2; PDBTitle: crystal structure of capz bound to the uncapping motif from carmil Phyre2 PDB 1js8 chain A Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 9.3% Identity: 38% PDB header:oxygen storage/transport Chain: A: PDB Molecule:hemocyanin; PDBTitle: structure of a functional unit from octopus hemocyanin Phyre2 PDB 1hf9 chain B Region: 174 - 205 Aligned: 32 Modelled: 32 Confidence: 8.4% Identity: 25% PDB header:atpase inhibitor Chain: B: PDB Molecule:atpase inhibitor (mitochondrial); PDBTitle: c-terminal coiled-coil domain from bovine if1 Phyre2 PDB 1izn chain B Region: 177 - 192 Aligned: 16 Modelled: 16 Confidence: 8.3% Identity: 50% Fold: Subunits of heterodimeric actin filament capping protein Capz Superfamily: Subunits of heterodimeric actin filament capping protein Capz Family: Capz beta-1 subunit Phyre2 PDB 1js8 chain A domain 1 Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 8.0% Identity: 38% Fold: Di-copper centre-containing domain Superfamily: Di-copper centre-containing domain Family: Hemocyanin middle domain Phyre2 PDB 2k1k chain A Region: 97 - 127 Aligned: 31 Modelled: 31 Confidence: 7.2% Identity: 32% PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 Phyre2 PDB 2k1l chain B Region: 97 - 127 Aligned: 31 Modelled: 31 Confidence: 7.2% Identity: 32% PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 Phyre2 PDB 2k1k chain B Region: 97 - 127 Aligned: 31 Modelled: 31 Confidence: 7.2% Identity: 32% PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 Phyre2 PDB 2k1l chain A Region: 97 - 127 Aligned: 31 Modelled: 31 Confidence: 7.2% Identity: 32% PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 Phyre2 PDB 1wx2 chain A Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 7.2% Identity: 31% PDB header:oxidoreductase/metal transport Chain: A: PDB Molecule:tyrosinase; PDBTitle: crystal structure of the oxy-form of the copper-bound streptomyces2 castaneoglobisporus tyrosinase complexed with a caddie protein3 prepared by the addition of hydrogenperoxide Phyre2 PDB 1u11 chain A Region: 183 - 205 Aligned: 23 Modelled: 23 Confidence: 6.3% Identity: 4% Fold: Flavodoxin-like Superfamily: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Family: N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Phyre2 PDB 2knc chain B Region: 153 - 202 Aligned: 44 Modelled: 50 Confidence: 6.1% Identity: 18% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2fqc chain A Region: 92 - 98 Aligned: 7 Modelled: 7 Confidence: 5.8% Identity: 43% PDB header:toxin Chain: A: PDB Molecule:conotoxin pl14a; PDBTitle: solution structure of conotoxin pl14a Phyre2 PDB 1lnl chain B Region: 173 - 185 Aligned: 13 Modelled: 13 Confidence: 5.7% Identity: 38% PDB header:oxygen storage/transport Chain: B: PDB Molecule:hemocyanin; PDBTitle: structure of deoxygenated hemocyanin from rapana thomasiana Phyre2 1 c2p3xA_ 2 d1bt3a_ 3 c2kncA_ 4 c3npyB_ 5 c3qnqD_ 6 c2y9xC_ 7 c3lk2B_ 8 c1js8A_ 9 c1hf9B_ 10 d1iznb_ 11 d1js8a1 12 c2k1kA_ 13 c2k1lB_ 14 c2k1kB_ 15 c2k1lA_ 16 c1wx2A_ 17 d1u11a_ 18 c2kncB_ 19 c2fqcA_ 20 c1lnlB_ 21 22

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2p3xA_ 15.0 46 PDB header:oxidoreductase Chain: A: PDB Molecule:polyphenol oxidase, chloroplast; PDBTitle: crystal structure of grenache (vitis vinifera) polyphenol2 oxidase 2 d1bt3a_ 14.1 38 Fold:Di-copper centre-containing domain Superfamily:Di-copper centre-containing domain Family:Catechol oxidase 3 c2kncA_ 12.6 10 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 4 c3npyB_ 11.0 38 PDB header:oxidoreductase Chain: B: PDB Molecule:tyrosinase; PDBTitle: crystal structure of tyrosinase from bacillus megaterium soaked in2 cuso4 5 c3qnqD_ 10.6 47 PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system 6 c2y9xC_ 10.1 46 PDB header:oxidoreductase Chain: C: PDB Molecule:polyphenol oxidase; PDBTitle: crystal structure of ppo3, a tyrosinase from agaricus bisporus, in2 deoxy-form that contains additional unknown lectin-like subunit,3 with inhibitor tropolone 7 c3lk2B_ 9.4 50 PDB header:protein binding Chain: B: PDB Molecule:f-actin-capping protein subunit beta isoforms 1 and 2; PDBTitle: crystal structure of capz bound to the uncapping motif from carmil 8 c1js8A_ 9.3 38 PDB header:oxygen storage/transport Chain: A: PDB Molecule:hemocyanin; PDBTitle: structure of a functional unit from octopus hemocyanin 9 c1hf9B_ 8.4 25 PDB header:atpase inhibitor Chain: B: PDB Molecule:atpase inhibitor (mitochondrial); PDBTitle: c-terminal coiled-coil domain from bovine if1 10 d1iznb_ 8.3 50 Fold:Subunits of heterodimeric actin filament capping protein Capz Superfamily:Subunits of heterodimeric actin filament capping protein Capz Family:Capz beta-1 subunit 11 d1js8a1 8.0 38 Fold:Di-copper centre-containing domain Superfamily:Di-copper centre-containing domain Family:Hemocyanin middle domain 12 c2k1kA_ 7.2 32 PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 13 c2k1lB_ 7.2 32 PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 14 c2k1kB_ 7.2 32 PDB header:signaling protein Chain: B: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 4.3 15 c2k1lA_ 7.2 32 PDB header:signaling protein Chain: A: PDB Molecule:ephrin type-a receptor 1; PDBTitle: nmr structures of dimeric transmembrane domain of the2 receptor tyrosine kinase epha1 in lipid bicelles at ph 6.3 16 c1wx2A_ 7.2 31 PDB header:oxidoreductase/metal transport Chain: A: PDB Molecule:tyrosinase; PDBTitle: crystal structure of the oxy-form of the copper-bound streptomyces2 castaneoglobisporus tyrosinase complexed with a caddie protein3 prepared by the addition of hydrogenperoxide 17 d1u11a_ 6.3 4 Fold:Flavodoxin-like Superfamily:N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) Family:N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) 18 c2kncB_ 6.1 18 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 19 c2fqcA_ 5.8 43 PDB header:toxin Chain: A: PDB Molecule:conotoxin pl14a; PDBTitle: solution structure of conotoxin pl14a 20 c1lnlB_ 5.7 38 PDB header:oxygen storage/transport Chain: B: PDB Molecule:hemocyanin; PDBTitle: structure of deoxygenated hemocyanin from rapana thomasiana 21 c2fw9A_ not modelled 5.6 4 PDB header:lyase Chain: A: PDB Molecule:n5-carboxyaminoimidazole ribonucleotide mutase; PDBTitle: structure of pure (n5-carboxyaminoimidazole ribonucleotide mutase)2 h59f from the acidophilic bacterium acetobacter aceti, at ph 8 22 d1lnla1 not modelled 5.5 38 Fold:Di-copper centre-containing domain Superfamily:Di-copper centre-containing domain Family:Hemocyanin middle domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0