Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	I	Y	F	I	N	W	V	A	D	Y	E	L	K	M	I	Q	Y	L	K	K	K	Y	K	I	K	N	I	T	T	P	K	K	Y	N	W	I	N	K	K	I	S	K	I	G	M	D	N	A	W	L	G	R	L	F	I	K	H	Y
Secondary structure
SS confidence
Disorder		?																									?																			?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	N	D	I	K	K	D	D	I	I	I	I	N	D	S	V	V	N	K	G	I	N	K	Q	I	L	K	N	I	N	C	H	K	V	L	L	L	R	N	T	V	G	E	D	F	I	L	D	N	A	N	Y	F	D	I	I	Y	D	F	E
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		H	R	F	I	G	N	E	K	I	K	A	I	E	Q	F	F	P	I	G	M	D	E	I	R	N	Y	S	L	S	D	K	N	N	S	Q	P	I	C	F	F	L	G	R	D	K	G	R	L	Q	I	I	N	E	L	A	E	R	L	T	T
Secondary structure
SS confidence
Disorder																					?	?		?				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	G	C	K	L	D	F	N	V	V	K	D	K	T	S	S	T	T	S	K	Y	L	I	E	K	Q	I	S	Y	E	E	N	I	R	R	T	L	N	A	N	I	I	V	D	I	T	K	E	N	Q	S	G	W	T	L	R	I	L	E	A
Secondary structure
SS confidence
Disorder													?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		L	F	F	N	K	K	L	I	T	N	N	I	N	V	F	G	S	E	I	Y	S	E	S	R	F	F	I	I	G	H	D	D	W	D	K	L	E	Y	F	I	N	S	S	V	K	P	M	D	Y	D	S	L	Y	K	F	S	P	D	K	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.
Sequence		M	S	T	I	V	S	D	F	I	D	K
Secondary structure
SS confidence
Disorder									?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3oy2 chain A Region: 147 - 308 Aligned: 160 Modelled: 162 Confidence: 93.9% Identity: 19% PDB header:viral protein,transferase Chain: A: PDB Molecule:glycosyltransferase b736l; PDBTitle: crystal structure of a putative glycosyltransferase from paramecium2 bursaria chlorella virus ny2a Phyre2 PDB 2gej chain A Region: 128 - 306 Aligned: 176 Modelled: 179 Confidence: 91.2% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol mannosyltransferase (pima); PDBTitle: crystal structure of phosphatidylinositol mannosyltransferase (pima)2 from mycobacterium smegmatis in complex with gdp-man Phyre2 PDB 3c4v chain B Region: 148 - 306 Aligned: 157 Modelled: 159 Confidence: 89.4% Identity: 10% PDB header:transferase Chain: B: PDB Molecule:predicted glycosyltransferases; PDBTitle: structure of the retaining glycosyltransferase msha:the2 first step in mycothiol biosynthesis. organism:3 corynebacterium glutamicum : complex with udp and 1l-ins-1-4 p. Phyre2 PDB 2x0d chain A Region: 144 - 282 Aligned: 136 Modelled: 139 Confidence: 86.2% Identity: 11% PDB header:transferase Chain: A: PDB Molecule:wsaf; PDBTitle: apo structure of wsaf Phyre2 PDB 3rhz chain B Region: 50 - 251 Aligned: 192 Modelled: 200 Confidence: 85.1% Identity: 7% PDB header:transferase Chain: B: PDB Molecule:nucleotide sugar synthetase-like protein; PDBTitle: structure and functional analysis of a new subfamily of2 glycosyltransferases required for glycosylation of serine-rich3 streptococcal adhesions Phyre2 PDB 2xmp chain B Region: 151 - 306 Aligned: 154 Modelled: 156 Confidence: 85.1% Identity: 14% PDB header:sugar binding protein Chain: B: PDB Molecule:trehalose-synthase tret; PDBTitle: crystal structure of trehalose synthase tret mutant e326a2 from p.horishiki in complex with udp Phyre2 PDB 2r60 chain A Region: 169 - 306 Aligned: 122 Modelled: 124 Confidence: 69.6% Identity: 7% PDB header:transferase Chain: A: PDB Molecule:glycosyl transferase, group 1; PDBTitle: structure of apo sucrose phosphate synthase (sps) of2 halothermothrix orenii Phyre2 PDB 2bis chain A domain 1 Region: 152 - 306 Aligned: 152 Modelled: 155 Confidence: 64.4% Identity: 14% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Glycosyl transferases group 1 Phyre2 PDB 1uqu chain B Region: 151 - 307 Aligned: 152 Modelled: 157 Confidence: 63.1% Identity: 16% PDB header:synthase Chain: B: PDB Molecule:alpha, alpha-trehalose-phosphate synthase; PDBTitle: trehalose-6-phosphate from e. coli bound with udp-glucose. Phyre2 PDB 2x6r chain A Region: 151 - 306 Aligned: 154 Modelled: 155 Confidence: 59.5% Identity: 13% PDB header:isomerase Chain: A: PDB Molecule:trehalose-synthase tret; PDBTitle: crystal structure of trehalose synthase tret from p.2 horikoshi produced by soaking in trehalose Phyre2 PDB 2jjm chain H Region: 220 - 306 Aligned: 85 Modelled: 87 Confidence: 55.0% Identity: 14% PDB header:transferase Chain: H: PDB Molecule:glycosyl transferase, group 1 family protein; PDBTitle: crystal structure of a family gt4 glycosyltransferase from2 bacillus anthracis orf ba1558. Phyre2 PDB 1uqt chain A Region: 151 - 307 Aligned: 151 Modelled: 157 Confidence: 47.9% Identity: 14% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Trehalose-6-phosphate synthase, OtsA Phyre2 PDB 3oka chain A Region: 151 - 306 Aligned: 155 Modelled: 156 Confidence: 34.3% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:gdp-mannose-dependent alpha-(1-6)-phosphatidylinositol PDBTitle: crystal structure of corynebacterium glutamicum pimb' in complex with2 gdp-man (triclinic crystal form) Phyre2 PDB 1rzu chain A Region: 206 - 306 Aligned: 99 Modelled: 101 Confidence: 30.7% Identity: 16% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Glycosyl transferases group 1 Phyre2 PDB 3pe3 chain D Region: 151 - 250 Aligned: 97 Modelled: 100 Confidence: 29.8% Identity: 15% PDB header:transferase Chain: D: PDB Molecule:udp-n-acetylglucosamine--peptide n- PDBTitle: structure of human o-glcnac transferase and its complex with a peptide2 substrate Phyre2 PDB 2xcu chain C Region: 109 - 250 Aligned: 140 Modelled: 142 Confidence: 27.0% Identity: 14% PDB header:transferase Chain: C: PDB Molecule:3-deoxy-d-manno-2-octulosonic acid transferase; PDBTitle: membrane-embedded monofunctional glycosyltransferase waaa of aquifex2 aeolicus, comlex with cmp Phyre2 PDB 2khz chain B Region: 148 - 248 Aligned: 101 Modelled: 101 Confidence: 26.8% Identity: 17% PDB header:nuclear protein Chain: B: PDB Molecule:c-myc-responsive protein rcl; PDBTitle: solution structure of rcl Phyre2 PDB 2f9f chain A domain 1 Region: 152 - 278 Aligned: 124 Modelled: 127 Confidence: 26.6% Identity: 15% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Glycosyl transferases group 1 Phyre2 PDB 2q6v chain A Region: 109 - 307 Aligned: 191 Modelled: 198 Confidence: 26.0% Identity: 10% PDB header:transferase Chain: A: PDB Molecule:glucuronosyltransferase gumk; PDBTitle: crystal structure of gumk in complex with udp Phyre2 PDB 1jix chain A Region: 145 - 294 Aligned: 149 Modelled: 150 Confidence: 23.4% Identity: 19% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: beta-Glucosyltransferase (DNA-modifying) Phyre2 1 c3oy2A_ 2 c2gejA_ 3 c3c4vB_ 4 c2x0dA_ 5 c3rhzB_ 6 c2xmpB_ 7 c2r60A_ 8 d2bisa1 9 c1uquB_ 10 c2x6rA_ 11 c2jjmH_ 12 d1uqta_ 13 c3okaA_ 14 d1rzua_ 15 c3pe3D_ 16 c2xcuC_ 17 c2khzB_ 18 d2f9fa1 19 c2q6vA_ 20 d1jixa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3oy2A_ 93.9 19 PDB header:viral protein,transferase Chain: A: PDB Molecule:glycosyltransferase b736l; PDBTitle: crystal structure of a putative glycosyltransferase from paramecium2 bursaria chlorella virus ny2a 2 c2gejA_ 91.2 10 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol mannosyltransferase (pima); PDBTitle: crystal structure of phosphatidylinositol mannosyltransferase (pima)2 from mycobacterium smegmatis in complex with gdp-man 3 c3c4vB_ 89.4 10 PDB header:transferase Chain: B: PDB Molecule:predicted glycosyltransferases; PDBTitle: structure of the retaining glycosyltransferase msha:the2 first step in mycothiol biosynthesis. organism:3 corynebacterium glutamicum : complex with udp and 1l-ins-1-4 p. 4 c2x0dA_ 86.2 11 PDB header:transferase Chain: A: PDB Molecule:wsaf; PDBTitle: apo structure of wsaf 5 c3rhzB_ 85.1 7 PDB header:transferase Chain: B: PDB Molecule:nucleotide sugar synthetase-like protein; PDBTitle: structure and functional analysis of a new subfamily of2 glycosyltransferases required for glycosylation of serine-rich3 streptococcal adhesions 6 c2xmpB_ 85.1 14 PDB header:sugar binding protein Chain: B: PDB Molecule:trehalose-synthase tret; PDBTitle: crystal structure of trehalose synthase tret mutant e326a2 from p.horishiki in complex with udp 7 c2r60A_ 69.6 7 PDB header:transferase Chain: A: PDB Molecule:glycosyl transferase, group 1; PDBTitle: structure of apo sucrose phosphate synthase (sps) of2 halothermothrix orenii 8 d2bisa1 64.4 14 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Glycosyl transferases group 1 9 c1uquB_ 63.1 16 PDB header:synthase Chain: B: PDB Molecule:alpha, alpha-trehalose-phosphate synthase; PDBTitle: trehalose-6-phosphate from e. coli bound with udp-glucose. 10 c2x6rA_ 59.5 13 PDB header:isomerase Chain: A: PDB Molecule:trehalose-synthase tret; PDBTitle: crystal structure of trehalose synthase tret from p.2 horikoshi produced by soaking in trehalose 11 c2jjmH_ 55.0 14 PDB header:transferase Chain: H: PDB Molecule:glycosyl transferase, group 1 family protein; PDBTitle: crystal structure of a family gt4 glycosyltransferase from2 bacillus anthracis orf ba1558. 12 d1uqta_ 47.9 14 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Trehalose-6-phosphate synthase, OtsA 13 c3okaA_ 34.3 12 PDB header:transferase Chain: A: PDB Molecule:gdp-mannose-dependent alpha-(1-6)-phosphatidylinositol PDBTitle: crystal structure of corynebacterium glutamicum pimb' in complex with2 gdp-man (triclinic crystal form) 14 d1rzua_ 30.7 16 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Glycosyl transferases group 1 15 c3pe3D_ 29.8 15 PDB header:transferase Chain: D: PDB Molecule:udp-n-acetylglucosamine--peptide n- PDBTitle: structure of human o-glcnac transferase and its complex with a peptide2 substrate 16 c2xcuC_ 27.0 14 PDB header:transferase Chain: C: PDB Molecule:3-deoxy-d-manno-2-octulosonic acid transferase; PDBTitle: membrane-embedded monofunctional glycosyltransferase waaa of aquifex2 aeolicus, comlex with cmp 17 c2khzB_ 26.8 17 PDB header:nuclear protein Chain: B: PDB Molecule:c-myc-responsive protein rcl; PDBTitle: solution structure of rcl 18 d2f9fa1 26.6 15 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Glycosyl transferases group 1 19 c2q6vA_ 26.0 10 PDB header:transferase Chain: A: PDB Molecule:glucuronosyltransferase gumk; PDBTitle: crystal structure of gumk in complex with udp 20 d1jixa_ 23.4 19 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:beta-Glucosyltransferase (DNA-modifying) 21 c2vsnB_ not modelled 21.5 11 PDB header:transferase Chain: B: PDB Molecule:xcogt; PDBTitle: structure and topological arrangement of an o-glcnac2 transferase homolog: insight into molecular control of3 intracellular glycosylation 22 c3h16A_ not modelled 16.2 14 PDB header:signaling protein Chain: A: PDB Molecule:tir protein; PDBTitle: crystal structure of a bacteria tir domain, pdtir from2 paracoccus denitrificans 23 d1r0ka2 not modelled 12.9 12 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 24 d1q0qa2 not modelled 12.3 21 Fold:NAD(P)-binding Rossmann-fold domains Superfamily:NAD(P)-binding Rossmann-fold domains Family:Glyceraldehyde-3-phosphate dehydrogenase-like, N-terminal domain 25 d2iw1a1 not modelled 11.0 14 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Glycosyl transferases group 1 26 c2eghA_ not modelled 10.1 21 PDB header:oxidoreductase Chain: A: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase2 complexed with a magnesium ion, nadph and fosmidomycin 27 c3a14B_ not modelled 9.6 14 PDB header:oxidoreductase Chain: B: PDB Molecule:1-deoxy-d-xylulose 5-phosphate reductoisomerase; PDBTitle: crystal structure of dxr from thermotoga maritima, in complex with2 nadph 28 d1o6ca_ not modelled 7.9 11 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:UDP-N-acetylglucosamine 2-epimerase 29 d1ipaa1 not modelled 7.2 19 Fold:alpha/beta knot Superfamily:alpha/beta knot Family:SpoU-like RNA 2'-O ribose methyltransferase 30 c1q2lA_ not modelled 6.9 13 PDB header:hydrolase Chain: A: PDB Molecule:protease iii; PDBTitle: crystal structure of pitrilysin 31 d1m53a1 not modelled 6.2 12 Fold:Glycosyl hydrolase domain Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain 32 c2i6dA_ not modelled 6.1 11 PDB header:transferase Chain: A: PDB Molecule:rna methyltransferase, trmh family; PDBTitle: the structure of a putative rna methyltransferase of the trmh family2 from porphyromonas gingivalis. 33 c2f06B_ not modelled 5.9 14 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:conserved hypothetical protein; PDBTitle: crystal structure of protein bt0572 from bacteroides thetaiotaomicron 34 c2hlgA_ not modelled 5.4 44 PDB header:plant protein Chain: A: PDB Molecule:fruit-specific protein; PDBTitle: nmr solution structure of a new tomato peptide

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0