Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP69831
DateThu Jan 5 12:12:12 GMT 2012
Unique Job ID62e86fc840183265

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c2nscA_
Top template information
PDB header:chaperone
Chain: A: PDB Molecule:trigger factor;
PDBTitle: structures of and interactions between domains of trigger factor from2 themotoga maritima
Confidence and coverage
Confidence: 40.8% Coverage: 4%
20 residues ( 4% of your sequence) have been modelled with 40.8% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MFSEVMRYILDLGPTVMLPIVIIIFSKILGMKAGDCFKAGLHIGIGFVGIGLVIGLMLDS
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?
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   .........70.........80.........90.........100.........110.........120
Sequence  IGPAAKAMAENFDLNLHVVDVGWPGSSPMTWASQIALVAIPIAILVNVAMLLTRMTRVVN
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   .........130.........140.........150.........160.........170.........180
Sequence  VDIWNIWHMTFTGALLHLATGSWMIGMAGVVIHAAFVYKLGDWFARDTRNFFELEGIAIP
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   .........190.........200.........210.........220.........230.........240
Sequence  HGTSAYMGPIAVLVDAIIEKIPGVNRIKFSADDIQRKFGPFGEPVTVGFVMGLIIGILAG
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   .........250.........260.........270.........280.........290.........300
Sequence  YDVKGVLQLAVKTAAVMLLMPRVIKPIMDGLTPIAKQARSRLQAKFGGQEFLIGLDPALL
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?















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   .........310.........320.........330.........340.........350.........360
Sequence  LGHTAVVSASLIFIPLTILIAVCVPGNQVLPFGDLATIGFFVAMAVAVHRGNLFRTLISG
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   .........370.........380.........390.........400.........410.........420
Sequence  VIIMSITLWIATQTIGLHTQLAANAGALKAGGMVASMDQGGSPITWLLIQVFSPQNIPGF
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????????






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   .........430.........440.........450.
Sequence  IIIGAIYLTGIFMTWRRARGFIKQEKVVLAE
Secondary structure 

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????
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 2nsc chain A

3D model

Region: 200 - 219
Aligned: 20
Modelled: 20
Confidence: 40.8%
Identity: 25%
PDB header:chaperone
Chain: A: PDB Molecule:trigger factor;
PDBTitle: structures of and interactions between domains of trigger factor from2 themotoga maritima

Phyre2

PDB 1w26 chain A domain 2

3D model

Region: 200 - 219
Aligned: 20
Modelled: 20
Confidence: 35.3%
Identity: 20%
Fold: Ribosome binding domain-like
Superfamily: Trigger factor ribosome-binding domain
Family: Trigger factor ribosome-binding domain

Phyre2

PDB 1p9y chain A

3D model

Region: 200 - 219
Aligned: 20
Modelled: 20
Confidence: 34.3%
Identity: 20%
Fold: Ribosome binding domain-like
Superfamily: Trigger factor ribosome-binding domain
Family: Trigger factor ribosome-binding domain

Phyre2

PDB 1t11 chain A domain 2

3D model

Region: 200 - 219
Aligned: 20
Modelled: 20
Confidence: 33.7%
Identity: 15%
Fold: Ribosome binding domain-like
Superfamily: Trigger factor ribosome-binding domain
Family: Trigger factor ribosome-binding domain

Phyre2

PDB 2d3o chain 1

3D model

Region: 200 - 219
Aligned: 20
Modelled: 20
Confidence: 30.3%
Identity: 25%
PDB header:ribosome
Chain: 1: PDB Molecule:trigger factor;
PDBTitle: structure of ribosome binding domain of the trigger factor2 on the 50s ribosomal subunit from d. radiodurans

Phyre2

PDB 2yvx chain D

3D model

Region: 225 - 324
Aligned: 83
Modelled: 100
Confidence: 30.2%
Identity: 17%
PDB header:transport protein
Chain: D: PDB Molecule:mg2+ transporter mgte;
PDBTitle: crystal structure of magnesium transporter mgte

Phyre2

PDB 1t11 chain A

3D model

Region: 200 - 219
Aligned: 20
Modelled: 20
Confidence: 27.4%
Identity: 15%
PDB header:chaperone
Chain: A: PDB Molecule:trigger factor;
PDBTitle: trigger factor

Phyre2

PDB 2qgo chain A

3D model

Region: 274 - 297
Aligned: 24
Modelled: 24
Confidence: 25.7%
Identity: 13%
PDB header:biosynthetic protein
Chain: A: PDB Molecule:putative fe-s biosynthesis protein;
PDBTitle: crystal structure of a putative fe-s biosynthesis protein from2 lactobacillus acidophilus

Phyre2

PDB 1osd chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 21.7%
Identity: 21%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 1cpz chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 20.6%
Identity: 21%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 2k2p chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 18.7%
Identity: 21%
PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein atu1203;
PDBTitle: solution nmr structure of protein atu1203 from agrobacterium2 tumefaciens. northeast structural genomics consortium (nesg) target3 att10, ontario center for structural proteomics target atc1183

Phyre2

PDB 1yg0 chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 18.7%
Identity: 24%
PDB header:metal transport
Chain: A: PDB Molecule:cop associated protein;
PDBTitle: solution structure of apo-copp from helicobacter pylori

Phyre2

PDB 1mwz chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 18.7%
Identity: 21%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 1y3k chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 16.7%
Identity: 12%
PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the apo form of the fifth domain of2 menkes protein

Phyre2

PDB 2ga7 chain A

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 16.3%
Identity: 18%
PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the copper(i) form of the third metal-2 binding domain of atp7a protein (menkes disease protein)

Phyre2

PDB 1qb2 chain A

3D model

Region: 193 - 216
Aligned: 24
Modelled: 24
Confidence: 16.2%
Identity: 25%
Fold: Signal peptide-binding domain
Superfamily: Signal peptide-binding domain
Family: Signal peptide-binding domain

Phyre2

PDB 2p2e chain A domain 1

3D model

Region: 274 - 300
Aligned: 27
Modelled: 27
Confidence: 15.5%
Identity: 19%
Fold: HesB-like domain
Superfamily: HesB-like domain
Family: HesB-like domain

Phyre2

PDB 1p6t chain A domain 1

3D model

Region: 172 - 213
Aligned: 34
Modelled: 42
Confidence: 14.0%
Identity: 18%
Fold: Ferredoxin-like
Superfamily: HMA, heavy metal-associated domain
Family: HMA, heavy metal-associated domain

Phyre2

PDB 1jw2 chain A

3D model

Region: 192 - 202
Aligned: 11
Modelled: 11
Confidence: 13.9%
Identity: 27%
Fold: Open three-helical up-and-down bundle
Superfamily: Hemolysin expression modulating protein HHA
Family: Hemolysin expression modulating protein HHA

Phyre2

PDB 1vf5 chain R

3D model

Region: 130 - 160
Aligned: 31
Modelled: 31
Confidence: 13.5%
Identity: 26%
PDB header:photosynthesis
Chain: R: PDB Molecule:protein pet l;
PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus

Phyre2
1

c2nscA_
2

d1w26a2
3

d1p9ya_
4

d1t11a2
5

c2d3o1_
6

c2yvxD_
7

c1t11A_
8

c2qgoA_
9

d1osda_
10

d1cpza_
11

c2k2pA_
12

c1yg0A_
13

d1mwza_
14

c1y3kA_
15

c2ga7A_
16

d1qb2a_
17

d2p2ea1
18

d1p6ta1
19

d1jw2a_
20

c1vf5R_
21



22



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24



25



26



27



28



29



30



31



32



33



34



35



36



37



38



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42



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47



48



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52



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60



61



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63



64






Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c2nscA_



40.8 25 PDB header:chaperone
Chain: A: PDB Molecule:trigger factor;
PDBTitle: structures of and interactions between domains of trigger factor from2 themotoga maritima
2d1w26a2



35.3 20 Fold:Ribosome binding domain-like
Superfamily:Trigger factor ribosome-binding domain
Family:Trigger factor ribosome-binding domain
3d1p9ya_



34.3 20 Fold:Ribosome binding domain-like
Superfamily:Trigger factor ribosome-binding domain
Family:Trigger factor ribosome-binding domain
4d1t11a2



33.7 15 Fold:Ribosome binding domain-like
Superfamily:Trigger factor ribosome-binding domain
Family:Trigger factor ribosome-binding domain
5c2d3o1_



30.3 25 PDB header:ribosome
Chain: 1: PDB Molecule:trigger factor;
PDBTitle: structure of ribosome binding domain of the trigger factor2 on the 50s ribosomal subunit from d. radiodurans
6c2yvxD_



30.2 17 PDB header:transport protein
Chain: D: PDB Molecule:mg2+ transporter mgte;
PDBTitle: crystal structure of magnesium transporter mgte
7c1t11A_



27.4 15 PDB header:chaperone
Chain: A: PDB Molecule:trigger factor;
PDBTitle: trigger factor
8c2qgoA_



25.7 13 PDB header:biosynthetic protein
Chain: A: PDB Molecule:putative fe-s biosynthesis protein;
PDBTitle: crystal structure of a putative fe-s biosynthesis protein from2 lactobacillus acidophilus
9d1osda_



21.7 21 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
10d1cpza_



20.6 21 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
11c2k2pA_



18.7 21 PDB header:structural genomics, unknown function
Chain: A: PDB Molecule:uncharacterized protein atu1203;
PDBTitle: solution nmr structure of protein atu1203 from agrobacterium2 tumefaciens. northeast structural genomics consortium (nesg) target3 att10, ontario center for structural proteomics target atc1183
12c1yg0A_



18.7 24 PDB header:metal transport
Chain: A: PDB Molecule:cop associated protein;
PDBTitle: solution structure of apo-copp from helicobacter pylori
13d1mwza_



18.7 21 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
14c1y3kA_



16.7 12 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the apo form of the fifth domain of2 menkes protein
15c2ga7A_



16.3 18 PDB header:hydrolase
Chain: A: PDB Molecule:copper-transporting atpase 1;
PDBTitle: solution structure of the copper(i) form of the third metal-2 binding domain of atp7a protein (menkes disease protein)
16d1qb2a_



16.2 25 Fold:Signal peptide-binding domain
Superfamily:Signal peptide-binding domain
Family:Signal peptide-binding domain
17d2p2ea1



15.5 19 Fold:HesB-like domain
Superfamily:HesB-like domain
Family:HesB-like domain
18d1p6ta1



14.0 18 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
19d1jw2a_



13.9 27 Fold:Open three-helical up-and-down bundle
Superfamily:Hemolysin expression modulating protein HHA
Family:Hemolysin expression modulating protein HHA
20c1vf5R_



13.5 26 PDB header:photosynthesis
Chain: R: PDB Molecule:protein pet l;
PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus
21c2e75E_



not modelled 13.5 26 PDB header:photosynthesis
Chain: E: PDB Molecule:cytochrome b6-f complex subunit 6;
PDBTitle: crystal structure of the cytochrome b6f complex with 2-nonyl-4-2 hydroxyquinoline n-oxide (nqno) from m.laminosus
22c2e74E_



not modelled 13.5 26 PDB header:photosynthesis
Chain: E: PDB Molecule:cytochrome b6-f complex subunit 6;
PDBTitle: crystal structure of the cytochrome b6f complex from m.laminosus
23c2e76E_



not modelled 13.5 26 PDB header:photosynthesis
Chain: E: PDB Molecule:cytochrome b6-f complex subunit 6;
PDBTitle: crystal structure of the cytochrome b6f complex with tridecyl-2 stigmatellin (tds) from m.laminosus
24d2e74e1



not modelled 13.5 26 Fold:Single transmembrane helix
Superfamily:PetL subunit of the cytochrome b6f complex
Family:PetL subunit of the cytochrome b6f complex
25d1qzxa2



not modelled 13.2 25 Fold:Signal peptide-binding domain
Superfamily:Signal peptide-binding domain
Family:Signal peptide-binding domain
26c2ofhX_



not modelled 13.1 15 PDB header:hydrolase, membrane protein
Chain: X: PDB Molecule:zinc-transporting atpase;
PDBTitle: solution structure of the n-terminal domain of the zinc(ii) atpase2 ziaa in its apo form
27c2aj1A_



not modelled 13.1 15 PDB header:hydrolase
Chain: A: PDB Molecule:probable cadmium-transporting atpase;
PDBTitle: solution structure of apocada
28d2aw0a_



not modelled 12.6 26 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
29d1w4ha1



not modelled 12.1 19 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
30d1afia_



not modelled 11.7 18 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
31c3bdlA_



not modelled 11.2 28 PDB header:hydrolase
Chain: A: PDB Molecule:staphylococcal nuclease domain-containing
PDBTitle: crystal structure of a truncated human tudor-sn
32d1vyva2



not modelled 11.1 29 Fold:P-loop containing nucleoside triphosphate hydrolases
Superfamily:P-loop containing nucleoside triphosphate hydrolases
Family:Nucleotide and nucleoside kinases
33d2cyua1



not modelled 10.8 18 Fold:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Superfamily:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
Family:Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex
34d2c4ka1



not modelled 10.7 27 Fold:PRTase-like
Superfamily:PRTase-like
Family:Phosphoribosylpyrophosphate synthetase-like
35c2kt2A_



not modelled 10.2 29 PDB header:oxidoreductase
Chain: A: PDB Molecule:mercuric reductase;
PDBTitle: structure of nmera, the n-terminal hma domain of tn501 mercuric2 reductase
36d2ffha2



not modelled 9.9 29 Fold:Signal peptide-binding domain
Superfamily:Signal peptide-binding domain
Family:Signal peptide-binding domain
37c2kkhA_



not modelled 9.8 21 PDB header:metal transport
Chain: A: PDB Molecule:putative heavy metal transporter;
PDBTitle: structure of the zinc binding domain of the atpase hma4
38c1w26B_



not modelled 9.8 20 PDB header:chaperone
Chain: B: PDB Molecule:trigger factor;
PDBTitle: trigger factor in complex with the ribosome forms a2 molecular cradle for nascent proteins
39c2iy3A_



not modelled 9.6 25 PDB header:rna-binding
Chain: A: PDB Molecule:signal recognition particle protein ffh;
PDBTitle: structure of the e. coli signal recognition particle2 bound to a translating ribosome
40d1kvja_



not modelled 9.3 29 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
41d1vs6z1



not modelled 9.3 25 Fold:L28p-like
Superfamily:L28p-like
Family:Ribosomal protein L31p
42c2vzkD_



not modelled 8.8 26 PDB header:transferase
Chain: D: PDB Molecule:glutamate n-acetyltransferase 2 beta chain;
PDBTitle: structure of the acyl-enzyme complex of an n-terminal2 nucleophile (ntn) hydrolase, oat2
43c2oarA_



not modelled 8.6 18 PDB header:membrane protein
Chain: A: PDB Molecule:large-conductance mechanosensitive channel;
PDBTitle: mechanosensitive channel of large conductance (mscl)
44d1sb6a_



not modelled 8.6 15 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
45d1s6ua_



not modelled 8.4 35 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
46d1uwda_



not modelled 8.4 25 Fold:Alpha-lytic protease prodomain-like
Superfamily:Fe-S cluster assembly (FSCA) domain-like
Family:PaaD-like
47d1p6ta2



not modelled 8.3 21 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
48d2oara1



not modelled 7.5 18 Fold:Gated mechanosensitive channel
Superfamily:Gated mechanosensitive channel
Family:Gated mechanosensitive channel
49c3bvsA_



not modelled 7.4 10 PDB header:hydrolase
Chain: A: PDB Molecule:alkylpurine dna glycosylase alkd;
PDBTitle: crystal structure of bacillus cereus alkylpurine dna glycosylase alkd
50c2kelB_



not modelled 7.2 29 PDB header:transcription repressor
Chain: B: PDB Molecule:uncharacterized protein 56b;
PDBTitle: structure of the transcription regulator svtr from the2 hyperthermophilic archaeal virus sirv1
51c1vf5E_



not modelled 7.2 23 PDB header:photosynthesis
Chain: E: PDB Molecule:protein pet l;
PDBTitle: crystal structure of cytochrome b6f complex from m.laminosus
52c1qzwC_



not modelled 7.1 25 PDB header:signaling protein/rna
Chain: C: PDB Molecule:signal recognition 54 kda protein;
PDBTitle: crystal structure of the complete core of archaeal srp and2 implications for inter-domain communication
53c3k3gA_



not modelled 7.1 10 PDB header:transport protein
Chain: A: PDB Molecule:urea transporter;
PDBTitle: crystal structure of the urea transporter from desulfovibrio vulgaris2 bound to 1,3-dimethylurea
54d2qifa1



not modelled 7.1 13 Fold:Ferredoxin-like
Superfamily:HMA, heavy metal-associated domain
Family:HMA, heavy metal-associated domain
55d3elga1



not modelled 7.0 19 Fold:BLIP-like
Superfamily:BT0923-like
Family:BT0923-like
56d1mn8a_



not modelled 7.0 21 Fold:Retroviral matrix proteins
Superfamily:Retroviral matrix proteins
Family:MMLV matrix protein-like
57d2aq0a1



not modelled 6.8 24 Fold:SAM domain-like
Superfamily:RuvA domain 2-like
Family:Hef domain-like
58c2ksdA_



not modelled 6.6 10 PDB header:transferase
Chain: A: PDB Molecule:aerobic respiration control sensor protein arcb;
PDBTitle: backbone structure of the membrane domain of e. coli2 histidine kinase receptor arcb, center for structures of3 membrane proteins (csmp) target 4310c
59d1ftra1



not modelled 6.1 24 Fold:Ferredoxin-like
Superfamily:Formylmethanofuran:tetrahydromethanopterin formyltransferase
Family:Formylmethanofuran:tetrahydromethanopterin formyltransferase
60d1t3la2



not modelled 5.6 29 Fold:P-loop containing nucleoside triphosphate hydrolases
Superfamily:P-loop containing nucleoside triphosphate hydrolases
Family:Nucleotide and nucleoside kinases
61d1nyta2



not modelled 5.3 33 Fold:Aminoacid dehydrogenase-like, N-terminal domain
Superfamily:Aminoacid dehydrogenase-like, N-terminal domain
Family:Shikimate dehydrogenase-like
62d3duea1



not modelled 5.1 13 Fold:BLIP-like
Superfamily:BT0923-like
Family:BT0923-like
63c2wwaJ_



not modelled 5.1 7 PDB header:ribosome
Chain: J: PDB Molecule:60s ribosomal protein l19;
PDBTitle: cryo-em structure of idle yeast ssh1 complex bound to the2 yeast 80s ribosome
64c3dv0I_



not modelled 5.1 13 PDB header:oxidoreductase/transferase
Chain: I: PDB Molecule:dihydrolipoyllysine-residue acetyltransferase
PDBTitle: snapshots of catalysis in the e1 subunit of the pyruvate2 dehydrogenase multi-enzyme complex

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction 

Transmembrane helices have been predicted in your sequence to adopt the topology shown below



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0