Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	L	I	R	T	E	T	R	D	T	K	R	A	A	D	P	L	H	D	L	R	S	K	P	F	S	E	W	G	E	D	E	I	R	R	F	N	L	I	D	A	L	L	E	F	V	Y	T	D	T	S	S	P	F	G	I	G	M	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?		?						?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	D	Y	T	E	C	W	E	I	G	V	R	D	D	C	L	V	M	T	R	V	K	P	V	H	P	E	Y	A	K	H	W	N	M	K	G	V	M	N	D	K	T	R	F	H	A	D	K	W	V	G	Y	S	K	V	L	A	W	V	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		L	S	H	K	D	T	F	T	G	A	K	R	F	Q	Y	F	Q	T	M	Y	D	M	E	R	Q	I	N	A	N	L	P	V	G	G	L	P	N	V	D	T	E	R	T	G	K	L	F	Q	R	D	D	F	S	E	D	S	H	A	N	D
Secondary structure
SS confidence
Disorder																											?	?																		?	?		?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.
Sequence		P	K	L	V	G	D	D	Y	V	P	Q	A	P	E	Q	I	N
Secondary structure
SS confidence
Disorder		?										?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 4a1o chain B Region: 89 - 177 Aligned: 83 Modelled: 89 Confidence: 26.1% Identity: 19% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 2g39 chain A domain 1 Region: 145 - 196 Aligned: 43 Modelled: 43 Confidence: 24.3% Identity: 21% Fold: NagB/RpiA/CoA transferase-like Superfamily: NagB/RpiA/CoA transferase-like Family: CoA transferase alpha subunit-like Phyre2 PDB 2no8 chain A Region: 21 - 37 Aligned: 16 Modelled: 17 Confidence: 13.6% Identity: 31% PDB header:immune system Chain: A: PDB Molecule:colicin-e2 immunity protein; PDBTitle: nmr structure analysis of the colicin immuntiy protein im2 Phyre2 PDB 2l95 chain A Region: 25 - 37 Aligned: 13 Modelled: 13 Confidence: 13.5% Identity: 8% PDB header:hydrolase Chain: A: PDB Molecule:crammer; PDBTitle: solution structure of cytotoxic t-lymphocyte antigent-2(ctla protein),2 crammer at ph 6.0 Phyre2 PDB 3bq7 chain A Region: 24 - 37 Aligned: 14 Modelled: 14 Confidence: 12.3% Identity: 29% PDB header:transferase Chain: A: PDB Molecule:diacylglycerol kinase delta; PDBTitle: sam domain of diacylglycerol kinase delta1 (e35g) Phyre2 PDB 1iv8 chain A domain 2 Region: 2 - 16 Aligned: 15 Modelled: 15 Confidence: 12.3% Identity: 47% Fold: TIM beta/alpha-barrel Superfamily: (Trans)glycosidases Family: Amylase, catalytic domain Phyre2 PDB 1zo0 chain A domain 1 Region: 55 - 115 Aligned: 41 Modelled: 46 Confidence: 11.9% Identity: 7% Fold: Acyl-CoA N-acyltransferases (Nat) Superfamily: Acyl-CoA N-acyltransferases (Nat) Family: Ornithine decarboxylase antizyme-like Phyre2 PDB 2csb chain A domain 4 Region: 86 - 115 Aligned: 30 Modelled: 30 Confidence: 11.8% Identity: 33% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Topoisomerase V repeat domain Phyre2 PDB 2xqo chain A Region: 178 - 190 Aligned: 13 Modelled: 13 Confidence: 11.6% Identity: 38% PDB header:hydrolase Chain: A: PDB Molecule:cellulosome enzyme, dockerin type i; PDBTitle: ctcel124: a cellulase from clostridium thermocellum Phyre2 PDB 3hje chain A Region: 2 - 16 Aligned: 15 Modelled: 15 Confidence: 11.1% Identity: 47% PDB header:transferase Chain: A: PDB Molecule:704aa long hypothetical glycosyltransferase; PDBTitle: crystal structure of sulfolobus tokodaii hypothetical2 maltooligosyl trehalose synthase Phyre2 PDB 1v85 chain A Region: 19 - 73 Aligned: 55 Modelled: 55 Confidence: 10.3% Identity: 11% PDB header:apoptosis Chain: A: PDB Molecule:similar to ring finger protein 36; PDBTitle: sterile alpha motif (sam) domain of mouse bifunctional2 apoptosis regulator Phyre2 PDB 3es5 chain A Region: 127 - 150 Aligned: 22 Modelled: 24 Confidence: 9.1% Identity: 45% PDB header:virus Chain: A: PDB Molecule:putative capsid protein; PDBTitle: crystal structure of partitivirus (psv-f) Phyre2 PDB 1gxh chain A Region: 25 - 37 Aligned: 13 Modelled: 13 Confidence: 8.9% Identity: 23% Fold: Acyl carrier protein-like Superfamily: Colicin E immunity proteins Family: Colicin E immunity proteins Phyre2 PDB 3op0 chain B Region: 38 - 97 Aligned: 58 Modelled: 60 Confidence: 8.7% Identity: 21% PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide Phyre2 PDB 2nog chain A Region: 19 - 37 Aligned: 19 Modelled: 19 Confidence: 8.4% Identity: 21% PDB header:dna binding protein Chain: A: PDB Molecule:iswi protein; PDBTitle: sant domain structure of xenopus remodeling factor iswi Phyre2 PDB 2dld chain A domain 2 Region: 154 - 178 Aligned: 25 Modelled: 25 Confidence: 8.3% Identity: 24% Fold: Flavodoxin-like Superfamily: Formate/glycerate dehydrogenase catalytic domain-like Family: Formate/glycerate dehydrogenases, substrate-binding domain Phyre2 PDB 3bs7 chain A Region: 24 - 34 Aligned: 11 Modelled: 11 Confidence: 8.1% Identity: 18% PDB header:signaling protein Chain: A: PDB Molecule:protein aveugle; PDBTitle: crystal structure of the sterile alpha motif (sam) domain2 of hyphen/aveugle Phyre2 PDB 1l6l chain K Region: 134 - 157 Aligned: 24 Modelled: 24 Confidence: 8.0% Identity: 29% PDB header:lipid transport Chain: K: PDB Molecule:apolipoprotein a-ii; PDBTitle: structures of apolipoprotein a-ii and a lipid surrogate2 complex provide insights into apolipoprotein-lipid3 interactions Phyre2 PDB 2vlq chain A domain 1 Region: 25 - 37 Aligned: 13 Modelled: 13 Confidence: 7.4% Identity: 23% Fold: Acyl carrier protein-like Superfamily: Colicin E immunity proteins Family: Colicin E immunity proteins Phyre2 PDB 1j4a chain A domain 2 Region: 154 - 166 Aligned: 13 Modelled: 13 Confidence: 7.4% Identity: 31% Fold: Flavodoxin-like Superfamily: Formate/glycerate dehydrogenase catalytic domain-like Family: Formate/glycerate dehydrogenases, substrate-binding domain Phyre2 1 c4a1oB_ 2 d2g39a1 3 c2no8A_ 4 c2l95A_ 5 c3bq7A_ 6 d1iv8a2 7 d1zo0a1 8 d2csba4 9 c2xqoA_ 10 c3hjeA_ 11 c1v85A_ 12 c3es5A_ 13 d1gxha_ 14 c3op0B_ 15 c2nogA_ 16 d2dlda2 17 c3bs7A_ 18 c1l6lK_ 19 d2vlqa1 20 d1j4aa2 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c4a1oB_ 26.1 19 PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. 2 d2g39a1 24.3 21 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:CoA transferase alpha subunit-like 3 c2no8A_ 13.6 31 PDB header:immune system Chain: A: PDB Molecule:colicin-e2 immunity protein; PDBTitle: nmr structure analysis of the colicin immuntiy protein im2 4 c2l95A_ 13.5 8 PDB header:hydrolase Chain: A: PDB Molecule:crammer; PDBTitle: solution structure of cytotoxic t-lymphocyte antigent-2(ctla protein),2 crammer at ph 6.0 5 c3bq7A_ 12.3 29 PDB header:transferase Chain: A: PDB Molecule:diacylglycerol kinase delta; PDBTitle: sam domain of diacylglycerol kinase delta1 (e35g) 6 d1iv8a2 12.3 47 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 7 d1zo0a1 11.9 7 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:Ornithine decarboxylase antizyme-like 8 d2csba4 11.8 33 Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:Topoisomerase V repeat domain 9 c2xqoA_ 11.6 38 PDB header:hydrolase Chain: A: PDB Molecule:cellulosome enzyme, dockerin type i; PDBTitle: ctcel124: a cellulase from clostridium thermocellum 10 c3hjeA_ 11.1 47 PDB header:transferase Chain: A: PDB Molecule:704aa long hypothetical glycosyltransferase; PDBTitle: crystal structure of sulfolobus tokodaii hypothetical2 maltooligosyl trehalose synthase 11 c1v85A_ 10.3 11 PDB header:apoptosis Chain: A: PDB Molecule:similar to ring finger protein 36; PDBTitle: sterile alpha motif (sam) domain of mouse bifunctional2 apoptosis regulator 12 c3es5A_ 9.1 45 PDB header:virus Chain: A: PDB Molecule:putative capsid protein; PDBTitle: crystal structure of partitivirus (psv-f) 13 d1gxha_ 8.9 23 Fold:Acyl carrier protein-like Superfamily:Colicin E immunity proteins Family:Colicin E immunity proteins 14 c3op0B_ 8.7 21 PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide 15 c2nogA_ 8.4 21 PDB header:dna binding protein Chain: A: PDB Molecule:iswi protein; PDBTitle: sant domain structure of xenopus remodeling factor iswi 16 d2dlda2 8.3 24 Fold:Flavodoxin-like Superfamily:Formate/glycerate dehydrogenase catalytic domain-like Family:Formate/glycerate dehydrogenases, substrate-binding domain 17 c3bs7A_ 8.1 18 PDB header:signaling protein Chain: A: PDB Molecule:protein aveugle; PDBTitle: crystal structure of the sterile alpha motif (sam) domain2 of hyphen/aveugle 18 c1l6lK_ 8.0 29 PDB header:lipid transport Chain: K: PDB Molecule:apolipoprotein a-ii; PDBTitle: structures of apolipoprotein a-ii and a lipid surrogate2 complex provide insights into apolipoprotein-lipid3 interactions 19 d2vlqa1 7.4 23 Fold:Acyl carrier protein-like Superfamily:Colicin E immunity proteins Family:Colicin E immunity proteins 20 d1j4aa2 7.4 31 Fold:Flavodoxin-like Superfamily:Formate/glycerate dehydrogenase catalytic domain-like Family:Formate/glycerate dehydrogenases, substrate-binding domain 21 c1ofcX_ not modelled 7.4 29 PDB header:nuclear protein Chain: X: PDB Molecule:iswi protein; PDBTitle: nucleosome recognition module of iswi atpase 22 d2cqqa1 not modelled 7.3 27 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Myb/SANT domain 23 d1f0la2 not modelled 7.3 29 Fold:ADP-ribosylation Superfamily:ADP-ribosylation Family:ADP-ribosylating toxins 24 d2hqya2 not modelled 6.9 19 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:FemXAB nonribosomal peptidyltransferases 25 c2wsfG_ not modelled 6.7 47 PDB header:photosynthesis Chain: G: PDB Molecule:photosystem i reaction center subunit v, PDBTitle: improved model of plant photosystem i 26 c3f75P_ not modelled 6.7 38 PDB header:hydrolase Chain: P: PDB Molecule:cathepsin l propeptide; PDBTitle: activated toxoplasma gondii cathepsin l (tgcpl) in complex with its2 propeptide 27 c2wscK_ not modelled 6.5 26 PDB header:photosynthesis Chain: K: PDB Molecule:photosystem i reaction center subunit psak, PDBTitle: improved model of plant photosystem i 28 d2fu5a1 not modelled 6.5 25 Fold:Mss4-like Superfamily:Mss4-like Family:RabGEF Mss4 29 d3buxb1 not modelled 6.2 24 Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins 30 d1ayia_ not modelled 6.2 23 Fold:Acyl carrier protein-like Superfamily:Colicin E immunity proteins Family:Colicin E immunity proteins 31 d1wwva1 not modelled 6.1 14 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:SAM (sterile alpha motif) domain 32 c3qodB_ not modelled 6.1 14 PDB header:dna binding protein Chain: B: PDB Molecule:heterocyst differentiation protein; PDBTitle: crystal structure of heterocyst differentiation protein, hetr from2 fischerella mv11 33 d1dpsa_ not modelled 5.7 71 Fold:Ferritin-like Superfamily:Ferritin-like Family:Ferritin 34 d1t92a_ not modelled 5.7 18 Fold:Pili subunits Superfamily:Pili subunits Family:Pseudopilin 35 c3cecA_ not modelled 5.5 57 PDB header:transcription Chain: A: PDB Molecule:putative antidote protein of plasmid maintenance system; PDBTitle: crystal structure of a putative antidote protein of plasmid2 maintenance system (npun_f2943) from nostoc punctiforme pcc 73102 at3 1.60 a resolution 36 c2o01G_ not modelled 5.3 47 PDB header:photosynthesis Chain: G: PDB Molecule:photosystem i reaction center subunit v, PDBTitle: the structure of a plant photosystem i supercomplex at 3.42 angstrom resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0