Phyre 2 Results for P76547

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Email | l.a.kelley@imperial.ac.uk
Description | P76547
Date | Thu Jan 5 12:24:24 GMT 2012
Unique Job ID | 579a475f46b22738

Summary |

Top model
Image coloured by rainbow N → C terminus
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Model (left) based on template c4a1oB_
Top template information
PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution.
Confidence and coverage
Confidence: | 26.1% | Coverage: | 42%
83 residues ( 42% of your sequence) have been modelled with 26.1% confidence by the single highest scoring template.
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3D viewing
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Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | S | L | I | R | T | E | T | R | D | T | K | R | A | A | D | P | L | H | D | L | R | S | K | P | F | S | E | W | G | E | D | E | I | R | R | F | N | L | I | D | A | L | L | E | F | V | Y | T | D | T | S | S | P | F | G | I | G | M | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  | ? | ? |  | ? |  |  |  |  |  | ? |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | F | D | Y | T | E | C | W | E | I | G | V | R | D | D | C | L | V | M | T | R | V | K | P | V | H | P | E | Y | A | K | H | W | N | M | K | G | V | M | N | D | K | T | R | F | H | A | D | K | W | V | G | Y | S | K | V | L | A | W | V | S
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | L | S | H | K | D | T | F | T | G | A | K | R | F | Q | Y | F | Q | T | M | Y | D | M | E | R | Q | I | N | A | N | L | P | V | G | G | L | P | N | V | D | T | E | R | T | G | K | L | F | Q | R | D | D | F | S | E | D | S | H | A | N | D
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | .
Sequence |  | P | K | L | V | G | D | D | Y | V | P | Q | A | P | E | Q | I | N
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c4a1oB_ |

### PDB 4a1o chain B

Region: 89 - 177
Aligned: 83
Modelled: 89
Confidence: 26.1%
Identity: 19%
PDB header:transferase-hydrolase
Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh;
PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution.

Phyre2
2 |
| d2g39a1 |

### PDB 2g39 chain A domain 1

Region: 145 - 196
Aligned: 43
Modelled: 43
Confidence: 24.3%
Identity: 21%
Fold: NagB/RpiA/CoA transferase-like
Superfamily: NagB/RpiA/CoA transferase-like
Family: CoA transferase alpha subunit-like

Phyre2
3 |
| c2no8A_ |

### PDB 2no8 chain A

Region: 21 - 37
Aligned: 16
Modelled: 17
Confidence: 13.6%
Identity: 31%
PDB header:immune system
Chain: A: PDB Molecule:colicin-e2 immunity protein;
PDBTitle: nmr structure analysis of the colicin immuntiy protein im2

Phyre2
4 |
| c2l95A_ |

### PDB 2l95 chain A

Region: 25 - 37
Aligned: 13
Modelled: 13
Confidence: 13.5%
Identity: 8%
PDB header:hydrolase
Chain: A: PDB Molecule:crammer;
PDBTitle: solution structure of cytotoxic t-lymphocyte antigent-2(ctla protein),2 crammer at ph 6.0

Phyre2
5 |
| c3bq7A_ |

### PDB 3bq7 chain A

Region: 24 - 37
Aligned: 14
Modelled: 14
Confidence: 12.3%
Identity: 29%
PDB header:transferase
Chain: A: PDB Molecule:diacylglycerol kinase delta;
PDBTitle: sam domain of diacylglycerol kinase delta1 (e35g)

Phyre2
6 |
| d1iv8a2 |

### PDB 1iv8 chain A domain 2

Region: 2 - 16
Aligned: 15
Modelled: 15
Confidence: 12.3%
Identity: 47%
Fold: TIM beta/alpha-barrel
Superfamily: (Trans)glycosidases
Family: Amylase, catalytic domain

Phyre2
7 |
| d1zo0a1 |

### PDB 1zo0 chain A domain 1

Region: 55 - 115
Aligned: 41
Modelled: 46
Confidence: 11.9%
Identity: 7%
Fold: Acyl-CoA N-acyltransferases (Nat)
Superfamily: Acyl-CoA N-acyltransferases (Nat)
Family: Ornithine decarboxylase antizyme-like

Phyre2
8 |
| d2csba4 |

### PDB 2csb chain A domain 4

Region: 86 - 115
Aligned: 30
Modelled: 30
Confidence: 11.8%
Identity: 33%
Fold: SAM domain-like
Superfamily: RuvA domain 2-like
Family: Topoisomerase V repeat domain

Phyre2
9 |
| c2xqoA_ |

### PDB 2xqo chain A

Region: 178 - 190
Aligned: 13
Modelled: 13
Confidence: 11.6%
Identity: 38%
PDB header:hydrolase
Chain: A: PDB Molecule:cellulosome enzyme, dockerin type i;
PDBTitle: ctcel124: a cellulase from clostridium thermocellum

Phyre2
10 |
| c3hjeA_ |

### PDB 3hje chain A

Region: 2 - 16
Aligned: 15
Modelled: 15
Confidence: 11.1%
Identity: 47%
PDB header:transferase
Chain: A: PDB Molecule:704aa long hypothetical glycosyltransferase;
PDBTitle: crystal structure of sulfolobus tokodaii hypothetical2 maltooligosyl trehalose synthase

Phyre2
11 |
| c1v85A_ |

### PDB 1v85 chain A

Region: 19 - 73
Aligned: 55
Modelled: 55
Confidence: 10.3%
Identity: 11%
PDB header:apoptosis
Chain: A: PDB Molecule:similar to ring finger protein 36;
PDBTitle: sterile alpha motif (sam) domain of mouse bifunctional2 apoptosis regulator

Phyre2
12 |
| c3es5A_ |

### PDB 3es5 chain A

Region: 127 - 150
Aligned: 22
Modelled: 24
Confidence: 9.1%
Identity: 45%
PDB header:virus
Chain: A: PDB Molecule:putative capsid protein;
PDBTitle: crystal structure of partitivirus (psv-f)

Phyre2
13 |
| d1gxha_ |

### PDB 1gxh chain A

Region: 25 - 37
Aligned: 13
Modelled: 13
Confidence: 8.9%
Identity: 23%
Fold: Acyl carrier protein-like
Superfamily: Colicin E immunity proteins
Family: Colicin E immunity proteins

Phyre2
14 |
| c3op0B_ |

### PDB 3op0 chain B

Region: 38 - 97
Aligned: 58
Modelled: 60
Confidence: 8.7%
Identity: 21%
PDB header:signaling protein/signaling protein regu
Chain: B: PDB Molecule:signal transduction protein cbl-c;
PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide

Phyre2
15 |
| c2nogA_ |

### PDB 2nog chain A

Region: 19 - 37
Aligned: 19
Modelled: 19
Confidence: 8.4%
Identity: 21%
PDB header:dna binding protein
Chain: A: PDB Molecule:iswi protein;
PDBTitle: sant domain structure of xenopus remodeling factor iswi

Phyre2
16 |
| d2dlda2 |

### PDB 2dld chain A domain 2

Region: 154 - 178
Aligned: 25
Modelled: 25
Confidence: 8.3%
Identity: 24%
Fold: Flavodoxin-like
Superfamily: Formate/glycerate dehydrogenase catalytic domain-like
Family: Formate/glycerate dehydrogenases, substrate-binding domain

Phyre2
17 |
| c3bs7A_ |

### PDB 3bs7 chain A

Region: 24 - 34
Aligned: 11
Modelled: 11
Confidence: 8.1%
Identity: 18%
PDB header:signaling protein
Chain: A: PDB Molecule:protein aveugle;
PDBTitle: crystal structure of the sterile alpha motif (sam) domain2 of hyphen/aveugle

Phyre2
18 |
| c1l6lK_ |

### PDB 1l6l chain K

Region: 134 - 157
Aligned: 24
Modelled: 24
Confidence: 8.0%
Identity: 29%
PDB header:lipid transport
Chain: K: PDB Molecule:apolipoprotein a-ii;
PDBTitle: structures of apolipoprotein a-ii and a lipid surrogate2 complex provide insights into apolipoprotein-lipid3 interactions

Phyre2
19 |
| d2vlqa1 |

### PDB 2vlq chain A domain 1

Region: 25 - 37
Aligned: 13
Modelled: 13
Confidence: 7.4%
Identity: 23%
Fold: Acyl carrier protein-like
Superfamily: Colicin E immunity proteins
Family: Colicin E immunity proteins

Phyre2
20 |
| d1j4aa2 |

### PDB 1j4a chain A domain 2

Region: 154 - 166
Aligned: 13
Modelled: 13
Confidence: 7.4%
Identity: 31%
Fold: Flavodoxin-like
Superfamily: Formate/glycerate dehydrogenase catalytic domain-like
Family: Formate/glycerate dehydrogenases, substrate-binding domain

Phyre2
21 |
22 |
23 |
24 |
25 |
26 |
27 |
28 |
29 |
30 |
31 |
32 |
33 |
34 |
35 |
36 |

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c4a1oB_ |
|  | 26.1 | 19 | PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution.
2 | d2g39a1 |
|  | 24.3 | 21 | Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:CoA transferase alpha subunit-like
3 | c2no8A_ |
|  | 13.6 | 31 | PDB header:immune system Chain: A: PDB Molecule:colicin-e2 immunity protein; PDBTitle: nmr structure analysis of the colicin immuntiy protein im2
4 | c2l95A_ |
|  | 13.5 | 8 | PDB header:hydrolase Chain: A: PDB Molecule:crammer; PDBTitle: solution structure of cytotoxic t-lymphocyte antigent-2(ctla protein),2 crammer at ph 6.0
5 | c3bq7A_ |
|  | 12.3 | 29 | PDB header:transferase Chain: A: PDB Molecule:diacylglycerol kinase delta; PDBTitle: sam domain of diacylglycerol kinase delta1 (e35g)
6 | d1iv8a2 |
|  | 12.3 | 47 | Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain
7 | d1zo0a1 |
|  | 11.9 | 7 | Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:Ornithine decarboxylase antizyme-like
8 | d2csba4 |
|  | 11.8 | 33 | Fold:SAM domain-like Superfamily:RuvA domain 2-like Family:Topoisomerase V repeat domain
9 | c2xqoA_ |
|  | 11.6 | 38 | PDB header:hydrolase Chain: A: PDB Molecule:cellulosome enzyme, dockerin type i; PDBTitle: ctcel124: a cellulase from clostridium thermocellum
10 | c3hjeA_ |
|  | 11.1 | 47 | PDB header:transferase Chain: A: PDB Molecule:704aa long hypothetical glycosyltransferase; PDBTitle: crystal structure of sulfolobus tokodaii hypothetical2 maltooligosyl trehalose synthase
11 | c1v85A_ |
|  | 10.3 | 11 | PDB header:apoptosis Chain: A: PDB Molecule:similar to ring finger protein 36; PDBTitle: sterile alpha motif (sam) domain of mouse bifunctional2 apoptosis regulator
12 | c3es5A_ |
|  | 9.1 | 45 | PDB header:virus Chain: A: PDB Molecule:putative capsid protein; PDBTitle: crystal structure of partitivirus (psv-f)
13 | d1gxha_ |
|  | 8.9 | 23 | Fold:Acyl carrier protein-like Superfamily:Colicin E immunity proteins Family:Colicin E immunity proteins
14 | c3op0B_ |
|  | 8.7 | 21 | PDB header:signaling protein/signaling protein regu Chain: B: PDB Molecule:signal transduction protein cbl-c; PDBTitle: crystal structure of cbl-c (cbl-3) tkb domain in complex with egfr2 py1069 peptide
15 | c2nogA_ |
|  | 8.4 | 21 | PDB header:dna binding protein Chain: A: PDB Molecule:iswi protein; PDBTitle: sant domain structure of xenopus remodeling factor iswi
16 | d2dlda2 |
|  | 8.3 | 24 | Fold:Flavodoxin-like Superfamily:Formate/glycerate dehydrogenase catalytic domain-like Family:Formate/glycerate dehydrogenases, substrate-binding domain
17 | c3bs7A_ |
|  | 8.1 | 18 | PDB header:signaling protein Chain: A: PDB Molecule:protein aveugle; PDBTitle: crystal structure of the sterile alpha motif (sam) domain2 of hyphen/aveugle
18 | c1l6lK_ |
|  | 8.0 | 29 | PDB header:lipid transport Chain: K: PDB Molecule:apolipoprotein a-ii; PDBTitle: structures of apolipoprotein a-ii and a lipid surrogate2 complex provide insights into apolipoprotein-lipid3 interactions
19 | d2vlqa1 |
|  | 7.4 | 23 | Fold:Acyl carrier protein-like Superfamily:Colicin E immunity proteins Family:Colicin E immunity proteins
20 | d1j4aa2 |
|  | 7.4 | 31 | Fold:Flavodoxin-like Superfamily:Formate/glycerate dehydrogenase catalytic domain-like Family:Formate/glycerate dehydrogenases, substrate-binding domain
21 | c1ofcX_ |
| not modelled | 7.4 | 29 | PDB header:nuclear protein Chain: X: PDB Molecule:iswi protein; PDBTitle: nucleosome recognition module of iswi atpase
22 | d2cqqa1 |
| not modelled | 7.3 | 27 | Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Myb/SANT domain
23 | d1f0la2 |
| not modelled | 7.3 | 29 | Fold:ADP-ribosylation Superfamily:ADP-ribosylation Family:ADP-ribosylating toxins
24 | d2hqya2 |
| not modelled | 6.9 | 19 | Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:FemXAB nonribosomal peptidyltransferases
25 | c2wsfG_ |
| not modelled | 6.7 | 47 | PDB header:photosynthesis Chain: G: PDB Molecule:photosystem i reaction center subunit v, PDBTitle: improved model of plant photosystem i
26 | c3f75P_ |
| not modelled | 6.7 | 38 | PDB header:hydrolase Chain: P: PDB Molecule:cathepsin l propeptide; PDBTitle: activated toxoplasma gondii cathepsin l (tgcpl) in complex with its2 propeptide
27 | c2wscK_ |
| not modelled | 6.5 | 26 | PDB header:photosynthesis Chain: K: PDB Molecule:photosystem i reaction center subunit psak, PDBTitle: improved model of plant photosystem i
28 | d2fu5a1 |
| not modelled | 6.5 | 25 | Fold:Mss4-like Superfamily:Mss4-like Family:RabGEF Mss4
29 | d3buxb1 |
| not modelled | 6.2 | 24 | Fold:EF Hand-like Superfamily:EF-hand Family:EF-hand modules in multidomain proteins
30 | d1ayia_ |
| not modelled | 6.2 | 23 | Fold:Acyl carrier protein-like Superfamily:Colicin E immunity proteins Family:Colicin E immunity proteins
31 | d1wwva1 |
| not modelled | 6.1 | 14 | Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:SAM (sterile alpha motif) domain
32 | c3qodB_ |
| not modelled | 6.1 | 14 | PDB header:dna binding protein Chain: B: PDB Molecule:heterocyst differentiation protein; PDBTitle: crystal structure of heterocyst differentiation protein, hetr from2 fischerella mv11
33 | d1dpsa_ |
| not modelled | 5.7 | 71 | Fold:Ferritin-like Superfamily:Ferritin-like Family:Ferritin
34 | d1t92a_ |
| not modelled | 5.7 | 18 | Fold:Pili subunits Superfamily:Pili subunits Family:Pseudopilin
35 | c3cecA_ |
| not modelled | 5.5 | 57 | PDB header:transcription Chain: A: PDB Molecule:putative antidote protein of plasmid maintenance system; PDBTitle: crystal structure of a putative antidote protein of plasmid2 maintenance system (npun_f2943) from nostoc punctiforme pcc 73102 at3 1.60 a resolution
36 | c2o01G_ |
| not modelled | 5.3 | 47 | PDB header:photosynthesis Chain: G: PDB Molecule:photosystem i reaction center subunit v, PDBTitle: the structure of a plant photosystem i supercomplex at 3.42 angstrom resolution

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0