Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	E	T	K	I	V	V	G	P	Q	P	F	S	V	G	E	E	Y	P	W	L	A	E	R	D	E	D	G	A	V	V	T	F	T	G	K	V	R	N	H	N	L	G	D	S	V	N	A	L	T	L	E	H	Y	P	G	M	T	E
Secondary structure
SS confidence
Disorder		?	?	?	?																																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		K	A	L	A	E	I	V	D	E	A	R	N	R	W	P	L	G	R	V	T	V	I	H	R	I	G	E	L	W	P	G	D	E	I	V	F	V	G	V	T	S	A	H	R	S	S	A	F	E	A	G	Q	F	I	M	D	Y	L	K	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150
Sequence		R	A	P	F	W	K	R	E	A	T	P	E	G	D	R	W	V	E	A	R	E	S	D	Q	Q	A	A	K	R	W
Secondary structure
SS confidence
Disorder														?	?					?	?	?	?	?	?			?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1fm0 chain E Region: 2 - 150 Aligned: 142 Modelled: 149 Confidence: 100.0% Identity: 100% Fold: alpha/beta-Hammerhead Superfamily: Molybdopterin synthase subunit MoaE Family: Molybdopterin synthase subunit MoaE Phyre2 PDB 2qie chain A Region: 3 - 139 Aligned: 136 Modelled: 137 Confidence: 100.0% Identity: 32% PDB header:transferase Chain: A: PDB Molecule:molybdopterin-converting factor subunit 2; PDBTitle: staphylococcus aureus molybdopterin synthase in complex2 with precursor z Phyre2 PDB 2omd chain B Region: 2 - 139 Aligned: 138 Modelled: 138 Confidence: 100.0% Identity: 29% PDB header:lyase Chain: B: PDB Molecule:molybdopterin-converting factor subunit 2; PDBTitle: crystal structure of molybdopterin converting factor subunit 22 (aq_2181) from aquifex aeolicus vf5 Phyre2 PDB 3rpf chain B Region: 6 - 142 Aligned: 132 Modelled: 137 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: B: PDB Molecule:molybdopterin synthase catalytic subunit; PDBTitle: protein-protein complex of subunit 1 and 2 of molybdopterin-converting2 factor from helicobacter pylori 26695 Phyre2 PDB 1nvj chain A Region: 2 - 127 Aligned: 118 Modelled: 126 Confidence: 100.0% Identity: 100% Fold: alpha/beta-Hammerhead Superfamily: Molybdopterin synthase subunit MoaE Family: Molybdopterin synthase subunit MoaE Phyre2 PDB 2wp4 chain A Region: 5 - 131 Aligned: 119 Modelled: 127 Confidence: 100.0% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:molybdopterin-converting factor subunit 2 1; PDBTitle: crystal structure of rv3119 from mycobacterium tuberculosis Phyre2 PDB 1v8c chain A Region: 5 - 67 Aligned: 63 Modelled: 63 Confidence: 98.8% Identity: 21% PDB header:protein binding Chain: A: PDB Molecule:moad related protein; PDBTitle: crystal structure of moad related protein from thermus2 thermophilus hb8 Phyre2 PDB 3ups chain A Region: 58 - 137 Aligned: 77 Modelled: 80 Confidence: 78.0% Identity: 17% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:iojap-like protein; PDBTitle: crystal structure of iojap-like protein from zymomonas mobilis Phyre2 PDB 2id1 chain A domain 1 Region: 61 - 137 Aligned: 74 Modelled: 77 Confidence: 61.0% Identity: 12% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Iojap/YbeB-like Phyre2 PDB 2o5a chain A domain 1 Region: 61 - 137 Aligned: 73 Modelled: 77 Confidence: 33.2% Identity: 15% Fold: Nucleotidyltransferase Superfamily: Nucleotidyltransferase Family: Iojap/YbeB-like Phyre2 PDB 2ys6 chain A Region: 91 - 139 Aligned: 46 Modelled: 48 Confidence: 32.4% Identity: 17% PDB header:ligase Chain: A: PDB Molecule:phosphoribosylglycinamide synthetase; PDBTitle: crystal structure of gar synthetase from geobacillus kaustophilus Phyre2 PDB 1n0u chain A domain 5 Region: 39 - 76 Aligned: 38 Modelled: 38 Confidence: 27.8% Identity: 24% Fold: Ferredoxin-like Superfamily: EF-G C-terminal domain-like Family: EF-G/eEF-2 domains III and V Phyre2 PDB 2dy1 chain A domain 5 Region: 39 - 73 Aligned: 35 Modelled: 35 Confidence: 27.4% Identity: 20% Fold: Ferredoxin-like Superfamily: EF-G C-terminal domain-like Family: EF-G/eEF-2 domains III and V Phyre2 PDB 1zco chain A Region: 84 - 120 Aligned: 35 Modelled: 37 Confidence: 21.1% Identity: 11% PDB header:lyase Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphoheptonate aldolase; PDBTitle: crystal structure of pyrococcus furiosus 3-deoxy-d-arabino-2 heptulosonate 7-phosphate synthase Phyre2 PDB 1sq1 chain A Region: 12 - 93 Aligned: 81 Modelled: 82 Confidence: 15.4% Identity: 9% Fold: Chorismate synthase, AroC Superfamily: Chorismate synthase, AroC Family: Chorismate synthase, AroC Phyre2 PDB 2i2x chain O Region: 50 - 113 Aligned: 64 Modelled: 64 Confidence: 13.4% Identity: 17% PDB header:transferase Chain: O: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri Phyre2 PDB 1xmb chain A domain 2 Region: 32 - 90 Aligned: 47 Modelled: 47 Confidence: 13.4% Identity: 11% Fold: Ferredoxin-like Superfamily: Bacterial exopeptidase dimerisation domain Family: Bacterial exopeptidase dimerisation domain Phyre2 PDB 1zrs chain B Region: 88 - 118 Aligned: 31 Modelled: 31 Confidence: 13.1% Identity: 16% PDB header:hydrolase Chain: B: PDB Molecule:hypothetical protein; PDBTitle: wild-type ld-carboxypeptidase Phyre2 PDB 3lvm chain B Region: 105 - 127 Aligned: 23 Modelled: 23 Confidence: 13.1% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:cysteine desulfurase; PDBTitle: crystal structure of e.coli iscs Phyre2 PDB 3cb4 chain D Region: 39 - 123 Aligned: 62 Modelled: 63 Confidence: 12.6% Identity: 16% PDB header:translation Chain: D: PDB Molecule:gtp-binding protein lepa; PDBTitle: the crystal structure of lepa Phyre2 1 d1fm0e_ 2 c2qieA_ 3 c2omdB_ 4 c3rpfB_ 5 d1nvja_ 6 c2wp4A_ 7 c1v8cA_ 8 c3upsA_ 9 d2id1a1 10 d2o5aa1 11 c2ys6A_ 12 d1n0ua5 13 d2dy1a5 14 c1zcoA_ 15 d1sq1a_ 16 c2i2xO_ 17 d1xmba2 18 c1zrsB_ 19 c3lvmB_ 20 c3cb4D_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1fm0e_ 100.0 100 Fold:alpha/beta-Hammerhead Superfamily:Molybdopterin synthase subunit MoaE Family:Molybdopterin synthase subunit MoaE 2 c2qieA_ 100.0 32 PDB header:transferase Chain: A: PDB Molecule:molybdopterin-converting factor subunit 2; PDBTitle: staphylococcus aureus molybdopterin synthase in complex2 with precursor z 3 c2omdB_ 100.0 29 PDB header:lyase Chain: B: PDB Molecule:molybdopterin-converting factor subunit 2; PDBTitle: crystal structure of molybdopterin converting factor subunit 22 (aq_2181) from aquifex aeolicus vf5 4 c3rpfB_ 100.0 19 PDB header:transferase Chain: B: PDB Molecule:molybdopterin synthase catalytic subunit; PDBTitle: protein-protein complex of subunit 1 and 2 of molybdopterin-converting2 factor from helicobacter pylori 26695 5 d1nvja_ 100.0 100 Fold:alpha/beta-Hammerhead Superfamily:Molybdopterin synthase subunit MoaE Family:Molybdopterin synthase subunit MoaE 6 c2wp4A_ 100.0 36 PDB header:transferase Chain: A: PDB Molecule:molybdopterin-converting factor subunit 2 1; PDBTitle: crystal structure of rv3119 from mycobacterium tuberculosis 7 c1v8cA_ 98.8 21 PDB header:protein binding Chain: A: PDB Molecule:moad related protein; PDBTitle: crystal structure of moad related protein from thermus2 thermophilus hb8 8 c3upsA_ 78.0 17 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:iojap-like protein; PDBTitle: crystal structure of iojap-like protein from zymomonas mobilis 9 d2id1a1 61.0 12 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 10 d2o5aa1 33.2 15 Fold:Nucleotidyltransferase Superfamily:Nucleotidyltransferase Family:Iojap/YbeB-like 11 c2ys6A_ 32.4 17 PDB header:ligase Chain: A: PDB Molecule:phosphoribosylglycinamide synthetase; PDBTitle: crystal structure of gar synthetase from geobacillus kaustophilus 12 d1n0ua5 27.8 24 Fold:Ferredoxin-like Superfamily:EF-G C-terminal domain-like Family:EF-G/eEF-2 domains III and V 13 d2dy1a5 27.4 20 Fold:Ferredoxin-like Superfamily:EF-G C-terminal domain-like Family:EF-G/eEF-2 domains III and V 14 c1zcoA_ 21.1 11 PDB header:lyase Chain: A: PDB Molecule:2-dehydro-3-deoxyphosphoheptonate aldolase; PDBTitle: crystal structure of pyrococcus furiosus 3-deoxy-d-arabino-2 heptulosonate 7-phosphate synthase 15 d1sq1a_ 15.4 9 Fold:Chorismate synthase, AroC Superfamily:Chorismate synthase, AroC Family:Chorismate synthase, AroC 16 c2i2xO_ 13.4 17 PDB header:transferase Chain: O: PDB Molecule:methyltransferase 1; PDBTitle: crystal structure of methanol:cobalamin methyltransferase complex2 mtabc from methanosarcina barkeri 17 d1xmba2 13.4 11 Fold:Ferredoxin-like Superfamily:Bacterial exopeptidase dimerisation domain Family:Bacterial exopeptidase dimerisation domain 18 c1zrsB_ 13.1 16 PDB header:hydrolase Chain: B: PDB Molecule:hypothetical protein; PDBTitle: wild-type ld-carboxypeptidase 19 c3lvmB_ 13.1 17 PDB header:transferase Chain: B: PDB Molecule:cysteine desulfurase; PDBTitle: crystal structure of e.coli iscs 20 c3cb4D_ 12.6 16 PDB header:translation Chain: D: PDB Molecule:gtp-binding protein lepa; PDBTitle: the crystal structure of lepa 21 c2kouA_ not modelled 12.1 13 PDB header:hydrolase Chain: A: PDB Molecule:dicer-like protein 4; PDBTitle: dicer like protein 22 d2od6a1 not modelled 10.6 26 Fold:Ferredoxin-like Superfamily:Dimeric alpha+beta barrel Family:Marine metagenome family DABB1 23 d2k49a2 not modelled 10.5 8 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 24 d2dkya1 not modelled 9.9 33 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Variant SAM domain 25 d1p3wa_ not modelled 9.7 17 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Cystathionine synthase-like 26 d1uwda_ not modelled 9.4 12 Fold:Alpha-lytic protease prodomain-like Superfamily:Fe-S cluster assembly (FSCA) domain-like Family:PaaD-like 27 d1rpma_ not modelled 8.6 17 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 28 c2xd4A_ not modelled 8.5 13 PDB header:ligase Chain: A: PDB Molecule:phosphoribosylamine--glycine ligase; PDBTitle: nucleotide-bound structures of bacillus subtilis glycinamide2 ribonucleotide synthetase 29 c3gjzB_ not modelled 8.0 21 PDB header:immune system Chain: B: PDB Molecule:microcin immunity protein mccf; PDBTitle: crystal structure of microcin immunity protein mccf from bacillus2 anthracis str. ames 30 d2qn6b1 not modelled 7.8 26 Fold:Ferredoxin-like Superfamily:eIF-2-alpha, C-terminal domain Family:eIF-2-alpha, C-terminal domain 31 d2k8ea1 not modelled 7.6 7 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 32 d2burb1 not modelled 7.4 24 Fold:Prealbumin-like Superfamily:Aromatic compound dioxygenase Family:Aromatic compound dioxygenase 33 d2k49a1 not modelled 7.3 7 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 34 d1dt9a3 not modelled 7.3 10 Fold:N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 Superfamily:N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 Family:N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1 35 c3iuuA_ not modelled 7.2 15 PDB header:hydrolase Chain: A: PDB Molecule:putative metallopeptidase; PDBTitle: crystal structure of putative metallopeptidase (yp_676511.1) from2 mesorhizobium sp. bnc1 at 2.13 a resolution 36 d1larb1 not modelled 7.2 14 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 37 d2k8ea2 not modelled 7.2 7 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 38 d2h80a1 not modelled 7.1 21 Fold:SAM domain-like Superfamily:SAM/Pointed domain Family:Variant SAM domain 39 c2bijA_ not modelled 6.9 16 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase, non-receptor type 5; PDBTitle: crystal structure of the human protein tyrosine phosphatase2 ptpn5 (step, striatum enriched enriched phosphatase) 40 c3okqA_ not modelled 6.9 22 PDB header:protein binding Chain: A: PDB Molecule:bud site selection protein 6; PDBTitle: crystal structure of a core domain of yeast actin nucleation cofactor2 bud6 41 d1udsa2 not modelled 6.8 17 Fold:Ribonuclease PH domain 2-like Superfamily:Ribonuclease PH domain 2-like Family:Ribonuclease PH domain 2-like 42 d3bida1 not modelled 6.8 27 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 43 d2auna2 not modelled 6.8 14 Fold:Flavodoxin-like Superfamily:Class I glutamine amidotransferase-like Family:LD-carboxypeptidase A N-terminal domain-like 44 d2pa2a1 not modelled 6.7 15 Fold:alpha/beta-Hammerhead Superfamily:Ribosomal protein L16p/L10e Family:Ribosomal protein L10e 45 c3eggC_ not modelled 6.6 40 PDB header:hydrolase Chain: C: PDB Molecule:spinophilin; PDBTitle: crystal structure of a complex between protein phosphatase 1 alpha2 (pp1) and the pp1 binding and pdz domains of spinophilin 46 c2h04A_ not modelled 6.5 21 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, receptor type, b,; PDBTitle: structural studies of protein tyrosine phosphatase beta2 catalytic domain in complex with inhibitors 47 c3e15D_ not modelled 6.4 12 PDB header:hydrolase Chain: D: PDB Molecule:glucose-6-phosphate 1-dehydrogenase; PDBTitle: 6-phosphogluconolactonase from plasmodium vivax 48 c1dd3D_ not modelled 6.1 24 PDB header:ribosome Chain: D: PDB Molecule:50s ribosomal protein l7/l12; PDBTitle: crystal structure of ribosomal protein l12 from thermotoga maritima 49 c1dd3C_ not modelled 6.1 24 PDB header:ribosome Chain: C: PDB Molecule:50s ribosomal protein l7/l12; PDBTitle: crystal structure of ribosomal protein l12 from thermotoga maritima 50 d1v6ba_ not modelled 6.1 40 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 51 d1p15a_ not modelled 6.1 18 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 52 c2i75A_ not modelled 6.1 10 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 4; PDBTitle: crystal structure of human protein tyrosine phosphatase n4 (ptpn4) 53 d2pjua1 not modelled 5.9 16 Fold:Chelatase-like Superfamily:PrpR receptor domain-like Family:PrpR receptor domain-like 54 d2o0ma1 not modelled 5.9 21 Fold:NagB/RpiA/CoA transferase-like Superfamily:NagB/RpiA/CoA transferase-like Family:SorC sugar-binding domain-like 55 c2o0mA_ not modelled 5.9 21 PDB header:transcription Chain: A: PDB Molecule:transcriptional regulator, sorc family; PDBTitle: the crystal structure of the putative sorc family transcriptional2 regulator from enterococcus faecalis 56 c1ceuA_ not modelled 5.8 35 PDB header:viral protein Chain: A: PDB Molecule:protein (hiv-1 regulatory protein n-terminal PDBTitle: nmr structure of the (1-51) n-terminal domain of the hiv-12 regulatory protein 57 c2pjuD_ not modelled 5.8 16 PDB header:transcription Chain: D: PDB Molecule:propionate catabolism operon regulatory protein; PDBTitle: crystal structure of propionate catabolism operon2 regulatory protein prpr 58 d2gnoa1 not modelled 5.7 6 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:DNA polymerase III clamp loader subunits, C-terminal domain 59 d1jlna_ not modelled 5.6 21 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 60 d1wfga_ not modelled 5.4 40 Fold:PDZ domain-like Superfamily:PDZ domain-like Family:PDZ domain 61 d1yfoa_ not modelled 5.4 16 Fold:(Phosphotyrosine protein) phosphatases II Superfamily:(Phosphotyrosine protein) phosphatases II Family:Higher-molecular-weight phosphotyrosine protein phosphatases 62 c2kl8A_ not modelled 5.4 19 PDB header:de novo protein Chain: A: PDB Molecule:or15; PDBTitle: solution nmr structure of de novo designed ferredoxin-like2 fold protein, northeast structural genomics consortium3 target or15 63 c3jrlA_ not modelled 5.4 12 PDB header:hydrolase Chain: A: PDB Molecule:oncogenic tyrosine phosphatase shp2; PDBTitle: crystal structure of the oncogenic tyrosine phosphatase shp2 complexed2 with a salicylic acid-based small molecule inhibitor 64 c2qdmA_ not modelled 5.4 25 PDB header:hydrolase Chain: A: PDB Molecule:tyrosine-protein phosphatase non-receptor type 7; PDBTitle: crystal structure of the heptp catalytic domain c270s/d236a/q314a2 mutant 65 d2k7ia1 not modelled 5.4 7 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 66 c2k7iB_ not modelled 5.4 7 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:upf0339 protein atu0232; PDBTitle: solution nmr structure of protein atu0232 from agrobacterium2 tumefaciens. northeast structural genomics consortium (nesg) target3 att3. ontario center for structural proteomics target atc0223. 67 c2b49A_ not modelled 5.2 9 PDB header:hydrolase Chain: A: PDB Molecule:protein tyrosine phosphatase, non-receptor type 3; PDBTitle: crystal structure of the catalytic domain of protein tyrosine2 phosphatase, non-receptor type 3

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0