Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	W	Y	Q	K	T	L	T	L	S	A	K	S	R	G	F	H	L	V	T	D	E	I	L	N	Q	L	A	D	M	P	R	V	N	I	G	L	L	H	L	L	L	Q	H	T	S	A	S	L	T	L	N	E	N	C	D	P	T	V	R
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	D	M	E	R	F	F	L	R	T	V	P	D	N	G	N	Y	E	H	D	Y	E	G	A	D	D	M	P	S	H	I	K	S	S	M	L	G	T	S	L	V	L	P	V	H	K	G	R	I	Q	T	G	T	W	Q	G	I	W	L	G
Secondary structure
SS confidence
Disorder																					?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.
Sequence		E	H	R	I	H	G	G	S	R	R	I	I	A	T	L	Q	G	E
Secondary structure
SS confidence
Disorder																		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2p6c chain B Region: 2 - 138 Aligned: 134 Modelled: 137 Confidence: 100.0% Identity: 26% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:aq_2013 protein; PDBTitle: crystal structure of hypothetical protein aq_2013 from aquifex2 aeolicus vf5. Phyre2 PDB 1vmj chain A Region: 2 - 138 Aligned: 134 Modelled: 137 Confidence: 100.0% Identity: 27% Fold: YjbQ-like Superfamily: YjbQ-like Family: YjbQ-like Phyre2 PDB 1vph chain A Region: 2 - 138 Aligned: 134 Modelled: 137 Confidence: 100.0% Identity: 23% Fold: YjbQ-like Superfamily: YjbQ-like Family: YjbQ-like Phyre2 PDB 1ve0 chain A Region: 2 - 138 Aligned: 131 Modelled: 137 Confidence: 100.0% Identity: 27% PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein (st2072); PDBTitle: crystal structure of uncharacterized protein st2072 from sulfolobus2 tokodaii Phyre2 PDB 2p6h chain B Region: 2 - 138 Aligned: 133 Modelled: 137 Confidence: 100.0% Identity: 26% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of hypothetical protein ape1520 from aeropyrum2 pernix k1 Phyre2 PDB 1vmf chain A Region: 3 - 138 Aligned: 133 Modelled: 136 Confidence: 100.0% Identity: 28% Fold: YjbQ-like Superfamily: YjbQ-like Family: YjbQ-like Phyre2 PDB 1vmh chain A Region: 6 - 136 Aligned: 126 Modelled: 131 Confidence: 100.0% Identity: 29% Fold: YjbQ-like Superfamily: YjbQ-like Family: YjbQ-like Phyre2 PDB 2cu5 chain C Region: 5 - 136 Aligned: 125 Modelled: 132 Confidence: 100.0% Identity: 27% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:conserved hypothetical protein tt1486; PDBTitle: crystal structure of the conserved hypothetical protein tt1486 from2 thermus thermophilus hb8 Phyre2 PDB 1ojj chain A Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 44.4% Identity: 17% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Glycosyl hydrolase family 7 catalytic core Phyre2 PDB 2rfy chain B Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 40.6% Identity: 14% PDB header:hydrolase Chain: B: PDB Molecule:cellulose 1,4-beta-cellobiosidase; PDBTitle: crystal structure of cellobiohydrolase from melanocarpus2 albomyces complexed with cellobiose Phyre2 PDB 1gpi chain A Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 40.6% Identity: 17% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Glycosyl hydrolase family 7 catalytic core Phyre2 PDB 1q9h chain A Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 36.7% Identity: 14% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Glycosyl hydrolase family 7 catalytic core Phyre2 PDB 3ovw chain A Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 35.3% Identity: 23% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Glycosyl hydrolase family 7 catalytic core Phyre2 PDB 2v3i chain A domain 1 Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 35.3% Identity: 17% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Glycosyl hydrolase family 7 catalytic core Phyre2 PDB 1f06 chain A domain 2 Region: 55 - 104 Aligned: 48 Modelled: 50 Confidence: 30.3% Identity: 15% Fold: FwdE/GAPDH domain-like Superfamily: Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family: Dihydrodipicolinate reductase-like Phyre2 PDB 1eg1 chain A Region: 95 - 129 Aligned: 35 Modelled: 35 Confidence: 28.9% Identity: 17% Fold: Concanavalin A-like lectins/glucanases Superfamily: Concanavalin A-like lectins/glucanases Family: Glycosyl hydrolase family 7 catalytic core Phyre2 PDB 2kmc chain A Region: 104 - 138 Aligned: 35 Modelled: 35 Confidence: 24.1% Identity: 14% PDB header:cell adhesion Chain: A: PDB Molecule:fermitin family homolog 1; PDBTitle: solution structure of the n-terminal domain of kindlin-1 Phyre2 PDB 2qmw chain A domain 2 Region: 112 - 126 Aligned: 14 Modelled: 15 Confidence: 18.6% Identity: 0% Fold: Ferredoxin-like Superfamily: ACT-like Family: Phenylalanine metabolism regulatory domain Phyre2 PDB 3hi2 chain D Region: 114 - 136 Aligned: 19 Modelled: 23 Confidence: 14.3% Identity: 11% PDB header:dna binding protein/toxin Chain: D: PDB Molecule:motility quorum-sensing regulator mqsr; PDBTitle: structure of the n-terminal domain of the e. coli antitoxin mqsa2 (ygit/b3021) in complex with the e. coli toxin mqsr (ygiu/b3022) Phyre2 PDB 2l57 chain A Region: 60 - 81 Aligned: 22 Modelled: 22 Confidence: 13.1% Identity: 14% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of an uncharacterized thioredoin-like protein from2 clostridium perfringens Phyre2 1 c2p6cB_ 2 d1vmja_ 3 d1vpha_ 4 c1ve0A_ 5 c2p6hB_ 6 d1vmfa_ 7 d1vmha_ 8 c2cu5C_ 9 d1ojja_ 10 c2rfyB_ 11 d1gpia_ 12 d1q9ha_ 13 d3ovwa_ 14 d2v3ia1 15 d1f06a2 16 d1eg1a_ 17 c2kmcA_ 18 d2qmwa2 19 c3hi2D_ 20 c2l57A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2p6cB_ 100.0 26 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:aq_2013 protein; PDBTitle: crystal structure of hypothetical protein aq_2013 from aquifex2 aeolicus vf5. 2 d1vmja_ 100.0 27 Fold:YjbQ-like Superfamily:YjbQ-like Family:YjbQ-like 3 d1vpha_ 100.0 23 Fold:YjbQ-like Superfamily:YjbQ-like Family:YjbQ-like 4 c1ve0A_ 100.0 27 PDB header:metal binding protein Chain: A: PDB Molecule:hypothetical protein (st2072); PDBTitle: crystal structure of uncharacterized protein st2072 from sulfolobus2 tokodaii 5 c2p6hB_ 100.0 26 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hypothetical protein; PDBTitle: crystal structure of hypothetical protein ape1520 from aeropyrum2 pernix k1 6 d1vmfa_ 100.0 28 Fold:YjbQ-like Superfamily:YjbQ-like Family:YjbQ-like 7 d1vmha_ 100.0 29 Fold:YjbQ-like Superfamily:YjbQ-like Family:YjbQ-like 8 c2cu5C_ 100.0 27 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:conserved hypothetical protein tt1486; PDBTitle: crystal structure of the conserved hypothetical protein tt1486 from2 thermus thermophilus hb8 9 d1ojja_ 44.4 17 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolase family 7 catalytic core 10 c2rfyB_ 40.6 14 PDB header:hydrolase Chain: B: PDB Molecule:cellulose 1,4-beta-cellobiosidase; PDBTitle: crystal structure of cellobiohydrolase from melanocarpus2 albomyces complexed with cellobiose 11 d1gpia_ 40.6 17 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolase family 7 catalytic core 12 d1q9ha_ 36.7 14 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolase family 7 catalytic core 13 d3ovwa_ 35.3 23 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolase family 7 catalytic core 14 d2v3ia1 35.3 17 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolase family 7 catalytic core 15 d1f06a2 30.3 15 Fold:FwdE/GAPDH domain-like Superfamily:Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain Family:Dihydrodipicolinate reductase-like 16 d1eg1a_ 28.9 17 Fold:Concanavalin A-like lectins/glucanases Superfamily:Concanavalin A-like lectins/glucanases Family:Glycosyl hydrolase family 7 catalytic core 17 c2kmcA_ 24.1 14 PDB header:cell adhesion Chain: A: PDB Molecule:fermitin family homolog 1; PDBTitle: solution structure of the n-terminal domain of kindlin-1 18 d2qmwa2 18.6 0 Fold:Ferredoxin-like Superfamily:ACT-like Family:Phenylalanine metabolism regulatory domain 19 c3hi2D_ 14.3 11 PDB header:dna binding protein/toxin Chain: D: PDB Molecule:motility quorum-sensing regulator mqsr; PDBTitle: structure of the n-terminal domain of the e. coli antitoxin mqsa2 (ygit/b3021) in complex with the e. coli toxin mqsr (ygiu/b3022) 20 c2l57A_ 13.1 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of an uncharacterized thioredoin-like protein from2 clostridium perfringens 21 d2j0pa1 not modelled 11.9 10 Fold:Heme iron utilization protein-like Superfamily:Heme iron utilization protein-like Family:HemS/ChuS-like 22 c2qmwA_ not modelled 11.2 9 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:prephenate dehydratase; PDBTitle: the crystal structure of the prephenate dehydratase (pdt) from2 staphylococcus aureus subsp. aureus mu50 23 d2drpa2 not modelled 10.7 50 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 24 d1phza1 not modelled 10.5 0 Fold:Ferredoxin-like Superfamily:ACT-like Family:Phenylalanine metabolism regulatory domain 25 d2hq2a1 not modelled 10.2 10 Fold:Heme iron utilization protein-like Superfamily:Heme iron utilization protein-like Family:HemS/ChuS-like 26 c3luyA_ not modelled 10.1 6 PDB header:isomerase Chain: A: PDB Molecule:probable chorismate mutase; PDBTitle: putative chorismate mutase from bifidobacterium adolescentis 27 d1rkea1 not modelled 10.0 24 Fold:Four-helical up-and-down bundle Superfamily:alpha-catenin/vinculin-like Family:alpha-catenin/vinculin 28 d1j5ya2 not modelled 9.7 10 Fold:HPr-like Superfamily:Putative transcriptional regulator TM1602, C-terminal domain Family:Putative transcriptional regulator TM1602, C-terminal domain 29 c3m45D_ not modelled 9.6 13 PDB header:cell adhesion Chain: D: PDB Molecule:cell adhesion molecule 2; PDBTitle: crystal structure of ig1 domain of mouse syncam 2 30 c3mwbA_ not modelled 8.9 6 PDB header:lyase Chain: A: PDB Molecule:prephenate dehydratase; PDBTitle: the crystal structure of prephenate dehydratase in complex with l-phe2 from arthrobacter aurescens to 2.0a 31 d1i8fa_ not modelled 7.8 6 Fold:Sm-like fold Superfamily:Sm-like ribonucleoproteins Family:Sm motif of small nuclear ribonucleoproteins, SNRNP 32 d1cl1a_ not modelled 7.6 33 Fold:PLP-dependent transferase-like Superfamily:PLP-dependent transferases Family:Cystathionine synthase-like 33 d1n8ia_ not modelled 7.3 17 Fold:TIM beta/alpha-barrel Superfamily:Malate synthase G Family:Malate synthase G 34 c3gqqD_ not modelled 6.8 17 PDB header:splicing Chain: D: PDB Molecule:protein unc-119 homolog a; PDBTitle: crystal structure of the human retinal protein 4 (unc-1192 homolog a). northeast structural genomics consortium3 target hr3066a 35 d1t01a1 not modelled 6.7 21 Fold:Four-helical up-and-down bundle Superfamily:alpha-catenin/vinculin-like Family:alpha-catenin/vinculin 36 d1rutx4 not modelled 5.9 30 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 37 c3i38L_ not modelled 5.2 24 PDB header:chaperone Chain: L: PDB Molecule:putative chaperone dnaj; PDBTitle: structure of a putative chaperone protein dnaj from klebsiella2 pneumoniae subsp. pneumoniae mgh 78578

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0