Secondary structure and disorder prediction

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Sequence		M	P	A	V	I	D	K	A	L	D	F	I	G	A	M	D	V	S	A	P	T	P	S	S	M	N	E	S	T	A	K	G	I	F	K	Y	L	K	E	L	G	V	P	A	S	A	A	D	I	T	A	R	A	D	Q	E	G	W	N	P
Secondary structure
SS confidence
Disorder		?	?													?	?	?	?	?	?	?	?	?	?	?	?																			?	?				?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.
Sequence		G	F	T	E	K	M	V	G	W	A	K	K	M	E	T	G	E	R	S	V	I	K	N	P	E	Y	F	S	T	Y	M	Q	E	E	L	K	A	L	V
Secondary structure
SS confidence
Disorder														?			?	?		?																			?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2es9 chain A domain 1 Region: 5 - 99 Aligned: 95 Modelled: 95 Confidence: 100.0% Identity: 63% Fold: YoaC-like Superfamily: YoaC-like Family: YoaC-like Phyre2 PDB 2cos chain A Region: 45 - 88 Aligned: 43 Modelled: 44 Confidence: 55.2% Identity: 35% PDB header:transferase Chain: A: PDB Molecule:serine/threonine protein kinase lats2; PDBTitle: solution structure of rsgi ruh-038, a uba domain from mouse2 lats2 (large tumor suppressor homolog 2) Phyre2 PDB 2cos chain A domain 1 Region: 55 - 88 Aligned: 33 Modelled: 34 Confidence: 43.5% Identity: 45% Fold: RuvA C-terminal domain-like Superfamily: UBA-like Family: UBA domain Phyre2 PDB 1t8s chain A Region: 79 - 98 Aligned: 20 Modelled: 20 Confidence: 33.0% Identity: 35% Fold: Phosphorylase/hydrolase-like Superfamily: Purine and uridine phosphorylases Family: Purine and uridine phosphorylases Phyre2 PDB 2q62 chain A Region: 20 - 90 Aligned: 70 Modelled: 71 Confidence: 25.3% Identity: 16% PDB header:flavoprotein Chain: A: PDB Molecule:arsh; PDBTitle: crystal structure of arsh from sinorhizobium meliloti Phyre2 PDB 1dpt chain A Region: 17 - 66 Aligned: 49 Modelled: 50 Confidence: 23.4% Identity: 20% Fold: Tautomerase/MIF Superfamily: Tautomerase/MIF Family: MIF-related Phyre2 PDB 2v4j chain A domain 3 Region: 32 - 72 Aligned: 41 Modelled: 41 Confidence: 17.8% Identity: 12% Fold: Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily: Nitrite and sulphite reductase 4Fe-4S domain-like Family: Nitrite and sulphite reductase 4Fe-4S domain-like Phyre2 PDB 1tns chain A Region: 41 - 59 Aligned: 19 Modelled: 19 Confidence: 16.5% Identity: 32% Fold: Putative DNA-binding domain Superfamily: Putative DNA-binding domain Family: Excisionase-like Phyre2 PDB 2o03 chain A Region: 33 - 63 Aligned: 31 Modelled: 31 Confidence: 14.8% Identity: 29% PDB header:gene regulation Chain: A: PDB Molecule:probable zinc uptake regulation protein furb; PDBTitle: crystal structure of furb from m. tuberculosis- a zinc uptake2 regulator Phyre2 PDB 3n70 chain F Region: 76 - 98 Aligned: 23 Modelled: 23 Confidence: 14.7% Identity: 26% PDB header:transport protein Chain: F: PDB Molecule:transport activator; PDBTitle: the crystal structure of the p-loop ntpase domain of the sigma-542 transport activator from e. coli to 2.8a Phyre2 PDB 1qpm chain A Region: 41 - 58 Aligned: 18 Modelled: 18 Confidence: 14.2% Identity: 44% Fold: Putative DNA-binding domain Superfamily: Putative DNA-binding domain Family: Excisionase-like Phyre2 PDB 1mzb chain A Region: 33 - 63 Aligned: 31 Modelled: 31 Confidence: 14.1% Identity: 23% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: FUR-like Phyre2 PDB 1jbo chain B Region: 19 - 46 Aligned: 28 Modelled: 28 Confidence: 10.4% Identity: 25% Fold: Globin-like Superfamily: Globin-like Family: Phycocyanin-like phycobilisome proteins Phyre2 PDB 1opa chain A Region: 35 - 43 Aligned: 9 Modelled: 9 Confidence: 10.1% Identity: 33% Fold: Lipocalins Superfamily: Lipocalins Family: Fatty acid binding protein-like Phyre2 PDB 1p6p chain A Region: 35 - 43 Aligned: 9 Modelled: 9 Confidence: 9.4% Identity: 33% Fold: Lipocalins Superfamily: Lipocalins Family: Fatty acid binding protein-like Phyre2 PDB 2zv3 chain E Region: 26 - 64 Aligned: 29 Modelled: 39 Confidence: 9.4% Identity: 28% PDB header:hydrolase Chain: E: PDB Molecule:peptidyl-trna hydrolase; PDBTitle: crystal structure of project mj0051 from methanocaldococcus2 jannaschii dsm 2661 Phyre2 PDB 2ph5 chain A Region: 57 - 70 Aligned: 14 Modelled: 14 Confidence: 9.2% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:homospermidine synthase; PDBTitle: crystal structure of the homospermidine synthase hss from legionella2 pneumophila in complex with nad, northeast structural genomics target3 lgr54 Phyre2 PDB 3em0 chain A Region: 35 - 43 Aligned: 9 Modelled: 9 Confidence: 8.9% Identity: 33% PDB header:lipid binding protein Chain: A: PDB Molecule:ileal bile acid-binding protein; PDBTitle: crystal structure of zebrafish ileal bile acid-bindin protein2 complexed with cholic acid (crystal form b). Phyre2 PDB 3civ chain A Region: 9 - 42 Aligned: 34 Modelled: 34 Confidence: 8.8% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:endo-beta-1,4-mannanase; PDBTitle: crystal structure of the endo-beta-1,4-mannanase from2 alicyclobacillus acidocaldarius Phyre2 PDB 2ftb chain A domain 1 Region: 35 - 43 Aligned: 9 Modelled: 9 Confidence: 8.7% Identity: 33% Fold: Lipocalins Superfamily: Lipocalins Family: Fatty acid binding protein-like Phyre2 1 d2es9a1 2 c2cosA_ 3 d2cosa1 4 d1t8sa_ 5 c2q62A_ 6 d1dpta_ 7 d2v4ja3 8 d1tnsa_ 9 c2o03A_ 10 c3n70F_ 11 d1qpma_ 12 d1mzba_ 13 d1jbob_ 14 d1opaa_ 15 d1p6pa_ 16 c2zv3E_ 17 c2ph5A_ 18 c3em0A_ 19 c3civA_ 20 d2ftba1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2es9a1 100.0 63 Fold:YoaC-like Superfamily:YoaC-like Family:YoaC-like 2 c2cosA_ 55.2 35 PDB header:transferase Chain: A: PDB Molecule:serine/threonine protein kinase lats2; PDBTitle: solution structure of rsgi ruh-038, a uba domain from mouse2 lats2 (large tumor suppressor homolog 2) 3 d2cosa1 43.5 45 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:UBA domain 4 d1t8sa_ 33.0 35 Fold:Phosphorylase/hydrolase-like Superfamily:Purine and uridine phosphorylases Family:Purine and uridine phosphorylases 5 c2q62A_ 25.3 16 PDB header:flavoprotein Chain: A: PDB Molecule:arsh; PDBTitle: crystal structure of arsh from sinorhizobium meliloti 6 d1dpta_ 23.4 20 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:MIF-related 7 d2v4ja3 17.8 12 Fold:Nitrite and sulphite reductase 4Fe-4S domain-like Superfamily:Nitrite and sulphite reductase 4Fe-4S domain-like Family:Nitrite and sulphite reductase 4Fe-4S domain-like 8 d1tnsa_ 16.5 32 Fold:Putative DNA-binding domain Superfamily:Putative DNA-binding domain Family:Excisionase-like 9 c2o03A_ 14.8 29 PDB header:gene regulation Chain: A: PDB Molecule:probable zinc uptake regulation protein furb; PDBTitle: crystal structure of furb from m. tuberculosis- a zinc uptake2 regulator 10 c3n70F_ 14.7 26 PDB header:transport protein Chain: F: PDB Molecule:transport activator; PDBTitle: the crystal structure of the p-loop ntpase domain of the sigma-542 transport activator from e. coli to 2.8a 11 d1qpma_ 14.2 44 Fold:Putative DNA-binding domain Superfamily:Putative DNA-binding domain Family:Excisionase-like 12 d1mzba_ 14.1 23 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:FUR-like 13 d1jbob_ 10.4 25 Fold:Globin-like Superfamily:Globin-like Family:Phycocyanin-like phycobilisome proteins 14 d1opaa_ 10.1 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 15 d1p6pa_ 9.4 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 16 c2zv3E_ 9.4 28 PDB header:hydrolase Chain: E: PDB Molecule:peptidyl-trna hydrolase; PDBTitle: crystal structure of project mj0051 from methanocaldococcus2 jannaschii dsm 2661 17 c2ph5A_ 9.2 36 PDB header:transferase Chain: A: PDB Molecule:homospermidine synthase; PDBTitle: crystal structure of the homospermidine synthase hss from legionella2 pneumophila in complex with nad, northeast structural genomics target3 lgr54 18 c3em0A_ 8.9 33 PDB header:lipid binding protein Chain: A: PDB Molecule:ileal bile acid-binding protein; PDBTitle: crystal structure of zebrafish ileal bile acid-bindin protein2 complexed with cholic acid (crystal form b). 19 c3civA_ 8.8 21 PDB header:hydrolase Chain: A: PDB Molecule:endo-beta-1,4-mannanase; PDBTitle: crystal structure of the endo-beta-1,4-mannanase from2 alicyclobacillus acidocaldarius 20 d2ftba1 8.7 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 21 d1d4aa_ not modelled 8.7 30 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Quinone reductase 22 d1kqwa_ not modelled 8.6 22 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 23 c3ca8B_ not modelled 8.6 15 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:protein ydcf; PDBTitle: crystal structure of escherichia coli ydcf, an s-adenosyl-l-methionine2 utilizing enzyme 24 d1qrda_ not modelled 8.6 27 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Quinone reductase 25 d2fs6a1 not modelled 8.4 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 26 c4a5qC_ not modelled 8.4 20 PDB header:hydrolase Chain: C: PDB Molecule:chi1; PDBTitle: crystal structure of the chitinase chi1 fitted into the 3d structure2 of the yersinia entomophaga toxin complex 27 c3oa5A_ not modelled 8.4 20 PDB header:hydrolase Chain: A: PDB Molecule:chi1; PDBTitle: the structure of chi1, a chitinase from yersinia entomophaga 28 d1ftpa_ not modelled 8.2 44 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 29 d1rlka_ not modelled 8.2 17 Fold:Peptidyl-tRNA hydrolase II Superfamily:Peptidyl-tRNA hydrolase II Family:Peptidyl-tRNA hydrolase II 30 d2cbra_ not modelled 8.1 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 31 c3nnkC_ not modelled 8.0 10 PDB header:transferase Chain: C: PDB Molecule:ureidoglycine-glyoxylate aminotransferase; PDBTitle: biochemical and structural characterization of a ureidoglycine2 aminotransferase in the klebsiella pneumoniae uric acid catabolic3 pathway 32 d1ggla_ not modelled 8.0 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 33 d1tw4a_ not modelled 7.9 44 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 34 d1vyfa_ not modelled 7.7 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 35 c2vmlD_ not modelled 7.6 20 PDB header:photosynthesis Chain: D: PDB Molecule:phycocyanin beta chain; PDBTitle: the monoclinic structure of phycocyanin from gloeobacter2 violaceus 36 d2fhfa5 not modelled 7.6 36 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:Amylase, catalytic domain 37 c2lbaA_ not modelled 7.6 33 PDB header:lipid binding protein Chain: A: PDB Molecule:babp protein; PDBTitle: solution structure of chicken ileal babp in complex with2 glycochenodeoxycholic acid 38 c2c4bB_ not modelled 7.6 21 PDB header:fusion protein Chain: B: PDB Molecule:barnase mcoeeti fusion; PDBTitle: inhibitor cystine knot protein mcoeeti fused to the2 catalytically inactive barnase mutant h102a 39 d2ogqa1 not modelled 7.6 55 Fold:Polo-box domain Superfamily:Polo-box domain Family:Polo-box duplicated region 40 d1fdqa_ not modelled 7.6 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 41 d1mdca_ not modelled 7.5 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 42 d1g7na_ not modelled 7.4 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 43 d1hmsa_ not modelled 7.4 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 44 d1o1va_ not modelled 7.2 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 45 d1lpja_ not modelled 7.2 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 46 d1lfoa_ not modelled 7.1 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 47 d2f73a1 not modelled 7.1 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 48 c3efeC_ not modelled 7.0 50 PDB header:chaperone Chain: C: PDB Molecule:thij/pfpi family protein; PDBTitle: the crystal structure of the thij/pfpi family protein from bacillus2 anthracis 49 d1kzwa_ not modelled 7.0 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 50 d1pmpa_ not modelled 6.9 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 51 c3pptA_ not modelled 6.8 44 PDB header:lipid binding protein Chain: A: PDB Molecule:sodium-calcium exchanger; PDBTitle: rep1-nxsq fatty acid transporter 52 d1hfoa_ not modelled 6.8 32 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:MIF-related 53 d1yiva1 not modelled 6.8 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 54 c3mwmA_ not modelled 6.7 23 PDB header:transcription Chain: A: PDB Molecule:putative metal uptake regulation protein; PDBTitle: graded expression of zinc-responsive genes through two regulatory2 zinc-binding sites in zur 55 d1cpcb_ not modelled 6.7 25 Fold:Globin-like Superfamily:Globin-like Family:Phycocyanin-like phycobilisome proteins 56 d1ifca_ not modelled 6.6 22 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 57 c2vqpA_ not modelled 6.6 75 PDB header:viral protein Chain: A: PDB Molecule:matrix protein; PDBTitle: structure of the matrix protein from human respiratory2 syncytial virus 58 d1bwya_ not modelled 6.5 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 59 d1eala_ not modelled 6.5 33 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 60 d1eyxa_ not modelled 6.5 21 Fold:Globin-like Superfamily:Globin-like Family:Phycocyanin-like phycobilisome proteins 61 d2a0aa1 not modelled 6.4 44 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 62 d1o8va_ not modelled 6.4 44 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 63 d1liaa_ not modelled 6.4 18 Fold:Globin-like Superfamily:Globin-like Family:Phycocyanin-like phycobilisome proteins 64 d2hnxa1 not modelled 6.3 56 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 65 d1crba_ not modelled 6.3 44 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 66 d1b56a_ not modelled 6.3 67 Fold:Lipocalins Superfamily:Lipocalins Family:Fatty acid binding protein-like 67 d1uyra2 not modelled 6.3 43 Fold:ClpP/crotonase Superfamily:ClpP/crotonase Family:Biotin dependent carboxylase carboxyltransferase domain 68 c2crvA_ not modelled 6.3 80 PDB header:translation Chain: A: PDB Molecule:translation initiation factor if-2; PDBTitle: solution structure of c-terminal domain of mitochondrial2 translational initiationfactor 2 69 c2vofA_ not modelled 6.3 42 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-related protein a1; PDBTitle: structure of mouse a1 bound to the puma bh3-domain 70 d2gdga1 not modelled 6.1 17 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:MIF-related 71 d1t0ia_ not modelled 6.1 18 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:NADPH-dependent FMN reductase 72 d2j2za2 not modelled 6.1 25 Fold:C2 domain-like Superfamily:Periplasmic chaperone C-domain Family:Periplasmic chaperone C-domain 73 c2gqsA_ not modelled 6.0 24 PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide PDBTitle: saicar synthetase complexed with cair-mg2+ and adp 74 c3kreA_ not modelled 6.0 15 PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide synthase; PDBTitle: crystal structure of phosphoribosylaminoimidazole-succinocarboxamide2 synthase from ehrlichia chaffeensis at 1.8a resolution 75 c2o8kA_ not modelled 5.8 55 PDB header:transcription/dna Chain: A: PDB Molecule:rna polymerase sigma factor rpon; PDBTitle: nmr structure of the sigma-54 rpon domain bound to the-242 promoter element 76 c2q9sA_ not modelled 5.8 56 PDB header:lipid binding protein Chain: A: PDB Molecule:fatty acid-binding protein; PDBTitle: linoleic acid bound to fatty acid binding protein 4 77 c3fwtA_ not modelled 5.8 29 PDB header:cytokine Chain: A: PDB Molecule:macrophage migration inhibitory factor-like PDBTitle: crystal structure of leishmania major mif2 78 c2z02A_ not modelled 5.7 24 PDB header:ligase Chain: A: PDB Molecule:phosphoribosylaminoimidazole-succinocarboxamide PDBTitle: crystal structure of2 phosphoribosylaminoimidazolesuccinocarboxamide synthase3 wit atp from methanocaldococcus jannaschii 79 d2fzva1 not modelled 5.7 14 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:NADPH-dependent FMN reductase 80 c2xtdB_ not modelled 5.5 43 PDB header:transcription Chain: B: PDB Molecule:tbl1 f-box-like/wd repeat-containing protein tbl1x; PDBTitle: structure of the tbl1 tetramerisation domain 81 c3nraA_ not modelled 5.5 20 PDB header:transferase Chain: A: PDB Molecule:aspartate aminotransferase; PDBTitle: crystal structure of an aspartate aminotransferase (yp_354942.1) from2 rhodobacter sphaeroides 2.4.1 at 2.15 a resolution 82 d1gd0a_ not modelled 5.4 21 Fold:Tautomerase/MIF Superfamily:Tautomerase/MIF Family:MIF-related 83 c2kuaA_ not modelled 5.4 36 PDB header:apoptosis Chain: A: PDB Molecule:bcl-2-like protein 10; PDBTitle: solution structure of a divergent bcl-2 protein 84 c2xteH_ not modelled 5.4 43 PDB header:transcription Chain: H: PDB Molecule:f-box-like/wd repeat-containing protein tbl1x; PDBTitle: structure of the tbl1 tetramerisation domain 85 d1o82a_ not modelled 5.3 50 Fold:Saposin-like Superfamily:Bacteriocin AS-48 Family:Bacteriocin AS-48 86 c2fu4B_ not modelled 5.1 29 PDB header:dna binding protein Chain: B: PDB Molecule:ferric uptake regulation protein; PDBTitle: crystal structure of the dna binding domain of e.coli fur (ferric2 uptake regulator) 87 c2xa6B_ not modelled 5.0 38 PDB header:transcription Chain: B: PDB Molecule:kh domain-containing\,rna-binding\,signal PDBTitle: structural basis for homodimerization of the src-associated2 during mitosis, 68 kd protein (sam68) qua1 domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0