Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	M	L	L	A	T	A	L	A	L	L	I	T	G	C	A	Q	Q	T	F	T	V	Q	N	K	Q	T	A	V	A	P	K	E	T	I	T	H	H	F	F	V	S	G	I	G	Q	K	K	T	V	D	A	A	K	I	C	G	G
Secondary structure
SS confidence
Disorder		?	?	?																							?	?	?	?	?	?	?	?	?	?													?	?	?	?	?							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.
Sequence		A	E	N	V	V	K	T	E	T	Q	Q	T	F	V	N	G	L	L	G	F	I	T	L	G	I	Y	T	P	L	E	A	R	V	Y	C	S	K
Secondary structure
SS confidence
Disorder		?								?																										?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zcz chain A domain 2 Region: 45 - 85 Aligned: 39 Modelled: 41 Confidence: 20.2% Identity: 33% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC Phyre2 PDB 1zcz chain A Region: 45 - 85 Aligned: 41 Modelled: 41 Confidence: 12.3% Identity: 24% PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution Phyre2 PDB 4a1o chain B Region: 45 - 85 Aligned: 41 Modelled: 41 Confidence: 11.3% Identity: 29% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 1xru chain A domain 1 Region: 38 - 51 Aligned: 14 Modelled: 14 Confidence: 9.2% Identity: 21% Fold: Double-stranded beta-helix Superfamily: RmlC-like cupins Family: KduI-like Phyre2 PDB 1h59 chain B Region: 83 - 89 Aligned: 7 Modelled: 7 Confidence: 9.1% Identity: 43% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Growth factor receptor domain Family: Growth factor receptor domain Phyre2 PDB 1gqp chain A Region: 86 - 96 Aligned: 11 Modelled: 11 Confidence: 5.9% Identity: 36% Fold: Galactose-binding domain-like Superfamily: Galactose-binding domain-like Family: APC10-like Phyre2 1 d1zcza2 2 c1zczA_ 3 c4a1oB_ 4 d1xrua1 5 d1h59b_ 6 d1gqpa_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1zcza2 20.2 33 Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC 2 c1zczA_ 12.3 24 PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution 3 c4a1oB_ 11.3 29 PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. 4 d1xrua1 9.2 21 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:KduI-like 5 d1h59b_ 9.1 43 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Growth factor receptor domain Family:Growth factor receptor domain 6 d1gqpa_ 5.9 36 Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:APC10-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0