Phyre 2 Results for P77330

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Email | l.a.kelley@imperial.ac.uk
Description | P77330
Date | Thu Jan 5 12:27:49 GMT 2012
Unique Job ID | 36c634875471f6ea

Summary |

Top model
Image coloured by rainbow N → C terminus
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Model (left) based on template d1zcza2
Top template information
Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
Confidence and coverage
Confidence: | 20.2% | Coverage: | 40%
39 residues ( 40% of your sequence) have been modelled with 20.2% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
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3D viewing
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Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | K | K | M | L | L | A | T | A | L | A | L | L | I | T | G | C | A | Q | Q | T | F | T | V | Q | N | K | Q | T | A | V | A | P | K | E | T | I | T | H | H | F | F | V | S | G | I | G | Q | K | K | T | V | D | A | A | K | I | C | G | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  | ? |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | .
Sequence |  | A | E | N | V | V | K | T | E | T | Q | Q | T | F | V | N | G | L | L | G | F | I | T | L | G | I | Y | T | P | L | E | A | R | V | Y | C | S | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| d1zcza2 |

### PDB 1zcz chain A domain 2

Region: 45 - 85
Aligned: 39
Modelled: 41
Confidence: 20.2%
Identity: 33%
Fold: Cytidine deaminase-like
Superfamily: Cytidine deaminase-like
Family: AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC

Phyre2
2 |
| c1zczA_ |

### PDB 1zcz chain A

Region: 45 - 85
Aligned: 41
Modelled: 41
Confidence: 12.3%
Identity: 24%
PDB header:transferase/hydrolase
Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh;
PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution

Phyre2
3 |
| c4a1oB_ |

### PDB 4a1o chain B

Region: 45 - 85
Aligned: 41
Modelled: 41
Confidence: 11.3%
Identity: 29%
PDB header:transferase-hydrolase
Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh;
PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution.

Phyre2
4 |
| d1xrua1 |

### PDB 1xru chain A domain 1

Region: 38 - 51
Aligned: 14
Modelled: 14
Confidence: 9.2%
Identity: 21%
Fold: Double-stranded beta-helix
Superfamily: RmlC-like cupins
Family: KduI-like

Phyre2
5 |
| d1h59b_ |

### PDB 1h59 chain B

Region: 83 - 89
Aligned: 7
Modelled: 7
Confidence: 9.1%
Identity: 43%
Fold: Knottins (small inhibitors, toxins, lectins)
Superfamily: Growth factor receptor domain
Family: Growth factor receptor domain

Phyre2
6 |
| d1gqpa_ |

### PDB 1gqp chain A

Region: 86 - 96
Aligned: 11
Modelled: 11
Confidence: 5.9%
Identity: 36%
Fold: Galactose-binding domain-like
Superfamily: Galactose-binding domain-like
Family: APC10-like

Phyre2

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | d1zcza2 |
|  | 20.2 | 33 | Fold:Cytidine deaminase-like Superfamily:Cytidine deaminase-like Family:AICAR transformylase domain of bifunctional purine biosynthesis enzyme ATIC
2 | c1zczA_ |
|  | 12.3 | 24 | PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution
3 | c4a1oB_ |
|  | 11.3 | 29 | PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution.
4 | d1xrua1 |
|  | 9.2 | 21 | Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:KduI-like
5 | d1h59b_ |
|  | 9.1 | 43 | Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Growth factor receptor domain Family:Growth factor receptor domain
6 | d1gqpa_ |
|  | 5.9 | 36 | Fold:Galactose-binding domain-like Superfamily:Galactose-binding domain-like Family:APC10-like

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0