Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	I	T	P	E	Q	A	R	E	A	L	D	A	W	I	C	R	P	G	M	T	Q	E	Q	A	T	I	L	I	T	E	A	F	W	A	L	K	E	R	P	N	I	D	V	Q	R	V	T	Y	E	G	G	A	I	D	Q	R	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?															?	?		?																	?	?											?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.
Sequence		G	V	N	R	V	K	I	F	E	R	W	K	A	I	D	T	R	D	K	R	E	K	F	T	A	L	V	P	A	I	M	E	A	T	T	G
Secondary structure
SS confidence
Disorder															?	?																			?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3c4r chain C Region: 2 - 95 Aligned: 84 Modelled: 94 Confidence: 100.0% Identity: 36% PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an uncharacterized protein encoded by2 cryptic prophage Phyre2 PDB 2qxv chain B Region: 63 - 70 Aligned: 8 Modelled: 8 Confidence: 21.3% Identity: 75% PDB header:gene regulation Chain: B: PDB Molecule:enhancer of zeste homolog 2; PDBTitle: structural basis of ezh2 recognition by eed Phyre2 PDB 1y7q chain A domain 1 Region: 62 - 87 Aligned: 25 Modelled: 26 Confidence: 19.9% Identity: 12% Fold: Acyl carrier protein-like Superfamily: Retrovirus capsid dimerization domain-like Family: SCAN domain Phyre2 PDB 2fi2 chain A domain 1 Region: 54 - 87 Aligned: 33 Modelled: 34 Confidence: 19.7% Identity: 15% Fold: Acyl carrier protein-like Superfamily: Retrovirus capsid dimerization domain-like Family: SCAN domain Phyre2 PDB 3lhr chain A Region: 54 - 87 Aligned: 33 Modelled: 34 Confidence: 15.7% Identity: 18% PDB header:transcription regulator Chain: A: PDB Molecule:zinc finger protein 24; PDBTitle: crystal structure of the scan domain from human znf24 Phyre2 PDB 3l6a chain A Region: 63 - 93 Aligned: 30 Modelled: 31 Confidence: 15.6% Identity: 17% PDB header:translation Chain: A: PDB Molecule:eukaryotic translation initiation factor 4 gamma 2; PDBTitle: crystal structure of the c-terminal region of human p97 Phyre2 PDB 3e96 chain B Region: 43 - 67 Aligned: 25 Modelled: 25 Confidence: 13.9% Identity: 20% PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 bacillus clausii Phyre2 PDB 2ek0 chain B Region: 21 - 53 Aligned: 33 Modelled: 33 Confidence: 12.5% Identity: 12% PDB header:metal binding protein Chain: B: PDB Molecule:stage v sporulation protein s (spovs) related protein; PDBTitle: stage v sporolation protein s (spovs) from thermus thermophilus zinc2 form Phyre2 PDB 2l53 chain B Region: 19 - 34 Aligned: 15 Modelled: 16 Confidence: 11.5% Identity: 40% PDB header:ca-binding protein/proton transport Chain: B: PDB Molecule:voltage-gated sodium channel type v alpha isoform b PDBTitle: solution nmr structure of apo-calmodulin in complex with the iq motif2 of human cardiac sodium channel nav1.5 Phyre2 PDB 3bd1 chain B Region: 58 - 96 Aligned: 33 Modelled: 39 Confidence: 10.3% Identity: 27% PDB header:transcription Chain: B: PDB Molecule:cro protein; PDBTitle: structure of the cro protein from putative prophage element xfaso 1 in2 xylella fastidiosa strain ann-1 Phyre2 PDB 1pu1 chain A Region: 21 - 37 Aligned: 17 Modelled: 17 Confidence: 9.4% Identity: 12% Fold: Hypothetical protein MTH677 Superfamily: Hypothetical protein MTH677 Family: Hypothetical protein MTH677 Phyre2 PDB 3fgg chain A Region: 50 - 60 Aligned: 11 Modelled: 11 Confidence: 8.7% Identity: 45% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein bce2196; PDBTitle: crystal structure of putative ecf-type sigma factor negative effector2 from bacillus cereus Phyre2 PDB 2a2j chain A domain 1 Region: 49 - 73 Aligned: 25 Modelled: 25 Confidence: 8.5% Identity: 24% Fold: Split barrel-like Superfamily: FMN-binding split barrel Family: PNP-oxidase like Phyre2 PDB 1tp6 chain A Region: 66 - 87 Aligned: 20 Modelled: 22 Confidence: 8.1% Identity: 30% Fold: Cystatin-like Superfamily: NTF2-like Family: PA1314-like Phyre2 PDB 2kxw chain B Region: 18 - 34 Aligned: 15 Modelled: 17 Confidence: 8.0% Identity: 33% PDB header:calcium-binding protein/metal transport Chain: B: PDB Molecule:sodium channel protein type 2 subunit alpha; PDBTitle: structure of the c-domain fragment of apo calmodulin bound to the iq2 motif of nav1.2 Phyre2 PDB 1xdt chain T Region: 54 - 96 Aligned: 35 Modelled: 43 Confidence: 7.4% Identity: 26% PDB header:complex (toxin/growth factor) Chain: T: PDB Molecule:diphtheria toxin; PDBTitle: complex of diphtheria toxin and heparin-binding epidermal growth2 factor Phyre2 PDB 1ijw chain C Region: 2 - 30 Aligned: 27 Modelled: 29 Confidence: 7.0% Identity: 15% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: Recombinase DNA-binding domain Phyre2 PDB 2nr5 chain A domain 1 Region: 21 - 77 Aligned: 55 Modelled: 0 Confidence: 7.0% Identity: 20% Fold: Ferritin-like Superfamily: SO2669-like Family: SO2669-like Phyre2 PDB 1ug3 chain A domain 2 Region: 61 - 94 Aligned: 33 Modelled: 34 Confidence: 6.7% Identity: 24% Fold: alpha-alpha superhelix Superfamily: ARM repeat Family: MIF4G domain-like Phyre2 PDB 2ow7 chain A Region: 65 - 87 Aligned: 23 Modelled: 23 Confidence: 6.7% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase 2; PDBTitle: golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1-2 thioniabicyclo[4.3.0]nonan-7,8-diol chloride Phyre2 1 c3c4rC_ 2 c2qxvB_ 3 d1y7qa1 4 d2fi2a1 5 c3lhrA_ 6 c3l6aA_ 7 c3e96B_ 8 c2ek0B_ 9 c2l53B_ 10 c3bd1B_ 11 d1pu1a_ 12 c3fggA_ 13 d2a2ja1 14 d1tp6a_ 15 c2kxwB_ 16 c1xdtT_ 17 d1ijwc_ 18 d2nr5a1 19 d1ug3a2 20 c2ow7A_ 21 22 23

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3c4rC_ 100.0 36 PDB header:structural genomics, unknown function Chain: C: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an uncharacterized protein encoded by2 cryptic prophage 2 c2qxvB_ 21.3 75 PDB header:gene regulation Chain: B: PDB Molecule:enhancer of zeste homolog 2; PDBTitle: structural basis of ezh2 recognition by eed 3 d1y7qa1 19.9 12 Fold:Acyl carrier protein-like Superfamily:Retrovirus capsid dimerization domain-like Family:SCAN domain 4 d2fi2a1 19.7 15 Fold:Acyl carrier protein-like Superfamily:Retrovirus capsid dimerization domain-like Family:SCAN domain 5 c3lhrA_ 15.7 18 PDB header:transcription regulator Chain: A: PDB Molecule:zinc finger protein 24; PDBTitle: crystal structure of the scan domain from human znf24 6 c3l6aA_ 15.6 17 PDB header:translation Chain: A: PDB Molecule:eukaryotic translation initiation factor 4 gamma 2; PDBTitle: crystal structure of the c-terminal region of human p97 7 c3e96B_ 13.9 20 PDB header:lyase Chain: B: PDB Molecule:dihydrodipicolinate synthase; PDBTitle: crystal structure of dihydrodipicolinate synthase from2 bacillus clausii 8 c2ek0B_ 12.5 12 PDB header:metal binding protein Chain: B: PDB Molecule:stage v sporulation protein s (spovs) related protein; PDBTitle: stage v sporolation protein s (spovs) from thermus thermophilus zinc2 form 9 c2l53B_ 11.5 40 PDB header:ca-binding protein/proton transport Chain: B: PDB Molecule:voltage-gated sodium channel type v alpha isoform b PDBTitle: solution nmr structure of apo-calmodulin in complex with the iq motif2 of human cardiac sodium channel nav1.5 10 c3bd1B_ 10.3 27 PDB header:transcription Chain: B: PDB Molecule:cro protein; PDBTitle: structure of the cro protein from putative prophage element xfaso 1 in2 xylella fastidiosa strain ann-1 11 d1pu1a_ 9.4 12 Fold:Hypothetical protein MTH677 Superfamily:Hypothetical protein MTH677 Family:Hypothetical protein MTH677 12 c3fggA_ 8.7 45 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein bce2196; PDBTitle: crystal structure of putative ecf-type sigma factor negative effector2 from bacillus cereus 13 d2a2ja1 8.5 24 Fold:Split barrel-like Superfamily:FMN-binding split barrel Family:PNP-oxidase like 14 d1tp6a_ 8.1 30 Fold:Cystatin-like Superfamily:NTF2-like Family:PA1314-like 15 c2kxwB_ 8.0 33 PDB header:calcium-binding protein/metal transport Chain: B: PDB Molecule:sodium channel protein type 2 subunit alpha; PDBTitle: structure of the c-domain fragment of apo calmodulin bound to the iq2 motif of nav1.2 16 c1xdtT_ 7.4 26 PDB header:complex (toxin/growth factor) Chain: T: PDB Molecule:diphtheria toxin; PDBTitle: complex of diphtheria toxin and heparin-binding epidermal growth2 factor 17 d1ijwc_ 7.0 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Recombinase DNA-binding domain 18 d2nr5a1 7.0 20 Fold:Ferritin-like Superfamily:SO2669-like Family:SO2669-like 19 d1ug3a2 6.7 24 Fold:alpha-alpha superhelix Superfamily:ARM repeat Family:MIF4G domain-like 20 c2ow7A_ 6.7 17 PDB header:hydrolase Chain: A: PDB Molecule:alpha-mannosidase 2; PDBTitle: golgi alpha-mannosidase ii complex with (1r,6s,7r,8s)-1-2 thioniabicyclo[4.3.0]nonan-7,8-diol chloride 21 d1hcra_ not modelled 6.4 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Recombinase DNA-binding domain 22 c2gqcA_ not modelled 5.7 18 PDB header:hydrolase Chain: A: PDB Molecule:rhomboid intramembrane protease; PDBTitle: solution structure of the n-terminal domain of rhomboid intramembrane2 protease from p. aeruginosa 23 d1i74a_ not modelled 5.5 38 Fold:DHH phosphoesterases Superfamily:DHH phosphoesterases Family:Manganese-dependent inorganic pyrophosphatase (family II)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0