Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	K	P	P	L	F	F	I	V	I	I	G	L	I	V	V	A	A	S	F	R	F	M	Q	Q	R	R	E	K	A	D	N	D	M	A	P	L	Q	Q	K	L	V	V	V	S	N	K	R	E	K	P	I	N	D	R	R	S	R	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																							?	?	?	?	?	?	?														?		?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.
Sequence		Q	E	V	T	P	A	G	T	S	I	R	Y	E	A	S	F	K	P	Q	S	G	G	M	E	Q	T	F	R	L	D	A	Q	Q	Y	H	A	L	T	V	G	D	K	G	T	L	S	Y	K	G	T	R	F	V	S	F	V	G	E	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?														?		?																															?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2l0c chain A Region: 35 - 118 Aligned: 84 Modelled: 84 Confidence: 100.0% Identity: 85% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative membrane protein; PDBTitle: solution nmr structure of protein sty4237 (residues 36-120) from2 salmonella enterica, northeast structural genomics consortium target3 slr115 Phyre2 PDB 3rd4 chain A Region: 36 - 118 Aligned: 71 Modelled: 83 Confidence: 98.9% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of propen_03304 from proteus penneri atcc 351982 northeast structural genomics consortium target id pvr55 Phyre2 PDB 2jys chain A Region: 54 - 101 Aligned: 46 Modelled: 48 Confidence: 70.8% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:protease/reverse transcriptase; PDBTitle: solution structure of simian foamy virus (mac) protease Phyre2 PDB 3uaj chain A Region: 61 - 107 Aligned: 46 Modelled: 47 Confidence: 18.5% Identity: 11% PDB header:viral protein/immune system Chain: A: PDB Molecule:envelope protein; PDBTitle: crystal structure of the envelope glycoprotein ectodomain from dengue2 virus serotype 4 in complex with the fab fragment of the chimpanzee3 monoclonal antibody 5h2 Phyre2 PDB 2pm5 chain B Region: 96 - 111 Aligned: 16 Modelled: 16 Confidence: 17.7% Identity: 38% PDB header:antimicrobial protein Chain: B: PDB Molecule:neutrophil defensin 1 (hnp-1) (hp-1) (hp1) (defensin, alpha PDBTitle: human alpha-defensin 1 derivative (hnp1) Phyre2 PDB 2pm5 chain A Region: 96 - 111 Aligned: 16 Modelled: 16 Confidence: 17.7% Identity: 38% PDB header:antimicrobial protein Chain: A: PDB Molecule:neutrophil defensin 1 (hnp-1) (hp-1) (hp1) (defensin, alpha PDBTitle: human alpha-defensin 1 derivative (hnp1) Phyre2 PDB 3sok chain B Region: 6 - 29 Aligned: 24 Modelled: 24 Confidence: 16.5% Identity: 17% PDB header:cell adhesion Chain: B: PDB Molecule:fimbrial protein; PDBTitle: dichelobacter nodosus pilin fima Phyre2 PDB 2axt chain I domain 1 Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 15.4% Identity: 17% Fold: Single transmembrane helix Superfamily: Photosystem II reaction center protein I, PsbI Family: PsbI-like Phyre2 PDB 2pm1 chain A Region: 96 - 111 Aligned: 16 Modelled: 16 Confidence: 14.8% Identity: 38% PDB header:antimicrobial protein Chain: A: PDB Molecule:neutrophil defensin 1 (hnp-1) (hp-1) (hp1) PDBTitle: derivative of human alpha-defensin 1 (hnp1) Phyre2 PDB 1oqw chain A Region: 6 - 29 Aligned: 24 Modelled: 24 Confidence: 14.3% Identity: 17% Fold: Pili subunits Superfamily: Pili subunits Family: Pilin Phyre2 PDB 1urz chain C Region: 62 - 107 Aligned: 44 Modelled: 46 Confidence: 13.7% Identity: 20% PDB header:virus/viral protein Chain: C: PDB Molecule:envelope protein; PDBTitle: low ph induced, membrane fusion conformation of the2 envelope protein of tick-borne encephalitis virus Phyre2 PDB 3msu chain A Region: 100 - 109 Aligned: 10 Modelled: 10 Confidence: 12.3% Identity: 50% PDB header:transferase Chain: A: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from francisella tularensis Phyre2 PDB 2h12 chain C Region: 100 - 109 Aligned: 10 Modelled: 10 Confidence: 11.9% Identity: 60% PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: structure of acetobacter aceti citrate synthase complexed2 with oxaloacetate and carboxymethyldethia coenzyme a (cmx) Phyre2 PDB 1k3p chain A Region: 100 - 109 Aligned: 10 Modelled: 10 Confidence: 11.4% Identity: 50% Fold: Citrate synthase Superfamily: Citrate synthase Family: Citrate synthase Phyre2 PDB 3mk7 chain B Region: 1 - 24 Aligned: 24 Modelled: 24 Confidence: 11.1% Identity: 13% PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit o; PDBTitle: the structure of cbb3 cytochrome oxidase Phyre2 PDB 2juf chain A Region: 92 - 106 Aligned: 15 Modelled: 15 Confidence: 10.9% Identity: 27% PDB header:gene regulation Chain: A: PDB Molecule:p53-associated parkin-like cytoplasmic protein; PDBTitle: nmr solution structure of parc cph domain. nesg target2 hr3443b/sgc-toronto Phyre2 PDB 1l3w chain A domain 5 Region: 33 - 74 Aligned: 42 Modelled: 42 Confidence: 10.3% Identity: 12% Fold: Immunoglobulin-like beta-sandwich Superfamily: Cadherin-like Family: Cadherin Phyre2 PDB 2axt chain K domain 1 Region: 1 - 22 Aligned: 22 Modelled: 22 Confidence: 9.3% Identity: 23% Fold: Single transmembrane helix Superfamily: Photosystem II reaction center protein K, PsbK Family: PsbK-like Phyre2 PDB 3a0b chain K Region: 1 - 21 Aligned: 21 Modelled: 21 Confidence: 9.3% Identity: 19% PDB header:electron transport Chain: K: PDB Molecule:photosystem ii reaction center protein k; PDBTitle: crystal structure of br-substituted photosystem ii complex Phyre2 PDB 2pil chain A Region: 6 - 29 Aligned: 24 Modelled: 24 Confidence: 8.8% Identity: 17% Fold: Pili subunits Superfamily: Pili subunits Family: Pilin Phyre2 1 c2l0cA_ 2 c3rd4A_ 3 c2jysA_ 4 c3uajA_ 5 c2pm5B_ 6 c2pm5A_ 7 c3sokB_ 8 d2axti1 9 c2pm1A_ 10 d1oqwa_ 11 c1urzC_ 12 c3msuA_ 13 c2h12C_ 14 d1k3pa_ 15 c3mk7B_ 16 c2jufA_ 17 d1l3wa5 18 d2axtk1 19 c3a0bk_ 20 d2pila_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2l0cA_ 100.0 85 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative membrane protein; PDBTitle: solution nmr structure of protein sty4237 (residues 36-120) from2 salmonella enterica, northeast structural genomics consortium target3 slr115 2 c3rd4A_ 98.9 27 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of propen_03304 from proteus penneri atcc 351982 northeast structural genomics consortium target id pvr55 3 c2jysA_ 70.8 20 PDB header:hydrolase Chain: A: PDB Molecule:protease/reverse transcriptase; PDBTitle: solution structure of simian foamy virus (mac) protease 4 c3uajA_ 18.5 11 PDB header:viral protein/immune system Chain: A: PDB Molecule:envelope protein; PDBTitle: crystal structure of the envelope glycoprotein ectodomain from dengue2 virus serotype 4 in complex with the fab fragment of the chimpanzee3 monoclonal antibody 5h2 5 c2pm5B_ 17.7 38 PDB header:antimicrobial protein Chain: B: PDB Molecule:neutrophil defensin 1 (hnp-1) (hp-1) (hp1) (defensin, alpha PDBTitle: human alpha-defensin 1 derivative (hnp1) 6 c2pm5A_ 17.7 38 PDB header:antimicrobial protein Chain: A: PDB Molecule:neutrophil defensin 1 (hnp-1) (hp-1) (hp1) (defensin, alpha PDBTitle: human alpha-defensin 1 derivative (hnp1) 7 c3sokB_ 16.5 17 PDB header:cell adhesion Chain: B: PDB Molecule:fimbrial protein; PDBTitle: dichelobacter nodosus pilin fima 8 d2axti1 15.4 17 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein I, PsbI Family:PsbI-like 9 c2pm1A_ 14.8 38 PDB header:antimicrobial protein Chain: A: PDB Molecule:neutrophil defensin 1 (hnp-1) (hp-1) (hp1) PDBTitle: derivative of human alpha-defensin 1 (hnp1) 10 d1oqwa_ 14.3 17 Fold:Pili subunits Superfamily:Pili subunits Family:Pilin 11 c1urzC_ 13.7 20 PDB header:virus/viral protein Chain: C: PDB Molecule:envelope protein; PDBTitle: low ph induced, membrane fusion conformation of the2 envelope protein of tick-borne encephalitis virus 12 c3msuA_ 12.3 50 PDB header:transferase Chain: A: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from francisella tularensis 13 c2h12C_ 11.9 60 PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: structure of acetobacter aceti citrate synthase complexed2 with oxaloacetate and carboxymethyldethia coenzyme a (cmx) 14 d1k3pa_ 11.4 50 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 15 c3mk7B_ 11.1 13 PDB header:oxidoreductase Chain: B: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit o; PDBTitle: the structure of cbb3 cytochrome oxidase 16 c2jufA_ 10.9 27 PDB header:gene regulation Chain: A: PDB Molecule:p53-associated parkin-like cytoplasmic protein; PDBTitle: nmr solution structure of parc cph domain. nesg target2 hr3443b/sgc-toronto 17 d1l3wa5 10.3 12 Fold:Immunoglobulin-like beta-sandwich Superfamily:Cadherin-like Family:Cadherin 18 d2axtk1 9.3 23 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein K, PsbK Family:PsbK-like 19 c3a0bk_ 9.3 19 PDB header:electron transport Chain: K: PDB Molecule:photosystem ii reaction center protein k; PDBTitle: crystal structure of br-substituted photosystem ii complex 20 d2pila_ 8.8 17 Fold:Pili subunits Superfamily:Pili subunits Family:Pilin 21 c3a0bK_ not modelled 8.6 19 PDB header:electron transport Chain: K: PDB Molecule:photosystem ii reaction center protein k; PDBTitle: crystal structure of br-substituted photosystem ii complex 22 c3pqsA_ not modelled 8.6 22 PDB header:lipid binding protein Chain: A: PDB Molecule:transferrin-binding protein; PDBTitle: the crystal structures of porcine pathogen aph87_tbpb 23 c2k21A_ not modelled 8.1 14 PDB header:membrane protein Chain: A: PDB Molecule:potassium voltage-gated channel subfamily e PDBTitle: nmr structure of human kcne1 in lmpg micelles at ph 6.0 and2 40 degree c 24 d1bdta_ not modelled 8.1 71 Fold:Ribbon-helix-helix Superfamily:Ribbon-helix-helix Family:Arc/Mnt-like phage repressors 25 c1pi7A_ not modelled 8.1 5 PDB header:viral protein Chain: A: PDB Molecule:vpu protein; PDBTitle: structure of the channel-forming trans-membrane domain of2 virus protein "u" (vpu) from hiv-1 26 c2gohA_ not modelled 8.1 5 PDB header:viral protein Chain: A: PDB Molecule:vpu protein; PDBTitle: three-dimensional structure of the trans-membrane domain of2 vpu from hiv-1 in aligned phospholipid bicelles 27 c1pi8A_ not modelled 8.1 5 PDB header:viral protein Chain: A: PDB Molecule:vpu protein; PDBTitle: structure of the channel-forming trans-membrane domain of2 virus protein "u" (vpu) from hiv-1 28 c2gofA_ not modelled 8.1 5 PDB header:viral protein Chain: A: PDB Molecule:vpu protein; PDBTitle: three-dimensional structure of the trans-membrane domain of2 vpu from hiv-1 in aligned phospholipid bicelles 29 c1pjeA_ not modelled 8.1 5 PDB header:viral protein Chain: A: PDB Molecule:vpu protein; PDBTitle: structure of the channel-forming trans-membrane domain of2 virus protein "u"(vpu) from hiv-1 30 d1xnea_ not modelled 7.8 30 Fold:PUA domain-like Superfamily:PUA domain-like Family:ProFAR isomerase associated domain 31 d1x6va1 not modelled 7.5 19 Fold:PUA domain-like Superfamily:PUA domain-like Family:ATP sulfurylase N-terminal domain 32 c2ky9A_ not modelled 7.5 28 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ydhk; PDBTitle: solution nmr structure of ydhk c-terminal domain from b.subtilis,2 northeast structural genomics consortium target target sr518 33 d1b28a_ not modelled 7.5 71 Fold:Ribbon-helix-helix Superfamily:Ribbon-helix-helix Family:Arc/Mnt-like phage repressors 34 d2jnga1 not modelled 7.1 25 Fold:SH3-like barrel Superfamily:Tudor/PWWP/MBT Family:CPH domain 35 c2ibpB_ not modelled 6.7 60 PDB header:transferase Chain: B: PDB Molecule:citrate synthase; PDBTitle: crystal structure of citrate synthase from pyrobaculum aerophilum 36 d2qqsa2 not modelled 6.6 14 Fold:SH3-like barrel Superfamily:Tudor/PWWP/MBT Family:Tudor domain 37 c2l2tA_ not modelled 6.4 17 PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain 38 c3hoeA_ not modelled 6.3 33 PDB header:transport protein Chain: A: PDB Molecule:tbpb; PDBTitle: crystal structure of surface lipoprotein 39 c2rddB_ not modelled 6.3 9 PDB header:membrane protein/transport protein Chain: B: PDB Molecule:upf0092 membrane protein yajc; PDBTitle: x-ray crystal structure of acrb in complex with a novel2 transmembrane helix. 40 d2qqra2 not modelled 6.3 16 Fold:SH3-like barrel Superfamily:Tudor/PWWP/MBT Family:Tudor domain 41 d1m56d_ not modelled 6.2 19 Fold:Single transmembrane helix Superfamily:Bacterial aa3 type cytochrome c oxidase subunit IV Family:Bacterial aa3 type cytochrome c oxidase subunit IV 42 c2j7aC_ not modelled 6.1 12 PDB header:oxidoreductase Chain: C: PDB Molecule:cytochrome c quinol dehydrogenase nrfh; PDBTitle: crystal structure of cytochrome c nitrite reductase nrfha2 complex from desulfovibrio vulgaris 43 d1czpa_ not modelled 5.9 4 Fold:beta-Grasp (ubiquitin-like) Superfamily:2Fe-2S ferredoxin-like Family:2Fe-2S ferredoxin-related 44 d1tula_ not modelled 5.8 14 Fold:beta-clip Superfamily:Tlp20, baculovirus telokin-like protein Family:Tlp20, baculovirus telokin-like protein 45 c3pquB_ not modelled 5.6 44 PDB header:lipid binding protein Chain: B: PDB Molecule:transferrin binding protein b; PDBTitle: the crystal structures of porcine pathogen ash57_tbpb 46 d1x68a1 not modelled 5.5 36 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 47 d1igub_ not modelled 5.5 29 Fold:SH3-like barrel Superfamily:C-terminal domain of transcriptional repressors Family:Transcriptional repressor protein KorB 48 d1o7xa_ not modelled 5.4 60 Fold:Citrate synthase Superfamily:Citrate synthase Family:Citrate synthase 49 d1igqa_ not modelled 5.4 29 Fold:SH3-like barrel Superfamily:C-terminal domain of transcriptional repressors Family:Transcriptional repressor protein KorB 50 c2r26C_ not modelled 5.3 60 PDB header:transferase Chain: C: PDB Molecule:citrate synthase; PDBTitle: the structure of the ternary complex of carboxymethyl2 coenzyme a and oxalateacetate with citrate synthase from3 the thermophilic archaeonthermoplasma acidophilum

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0