Secondary structure and disorder prediction

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Sequence		M	F	P	E	Y	R	D	L	I	S	R	L	K	N	E	N	P	R	F	M	S	L	F	D	K	H	N	K	L	D	H	E	I	A	R	K	E	G	S	D	G	R	G	Y	N	A	E	V	V	R	M	K	K	Q	K	L	Q	L	K	D
Secondary structure
SS confidence
Disorder		?	?	?	?																																	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.
Sequence		E	M	L	K	I	L	Q	Q	E	S	V	K	E	V
Secondary structure
SS confidence
Disorder										?			?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1zhc chain A Region: 1 - 74 Aligned: 72 Modelled: 74 Confidence: 100.0% Identity: 47% PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein hp1242; PDBTitle: solution structure of hp1242 from helicobacter pylori Phyre2 PDB 2a3d chain A Region: 6 - 65 Aligned: 56 Modelled: 60 Confidence: 59.9% Identity: 14% PDB header:three-helix bundle Chain: A: PDB Molecule:protein (de novo three-helix bundle); PDBTitle: solution structure of a de novo designed single chain three-2 helix bundle (a3d) Phyre2 PDB 1yyb chain A Region: 43 - 57 Aligned: 15 Modelled: 15 Confidence: 42.1% Identity: 20% PDB header:apoptosis Chain: A: PDB Molecule:programmed cell death protein 5; PDBTitle: solution structure of 1-26 fragment of human programmed2 cell death 5 protein Phyre2 PDB 3dds chain B Region: 12 - 74 Aligned: 63 Modelled: 63 Confidence: 42.0% Identity: 14% PDB header:transferase Chain: B: PDB Molecule:glycogen phosphorylase, liver form; PDBTitle: crystal structure of glycogen phosphorylase complexed with an2 anthranilimide based inhibitor gsk261 Phyre2 PDB 3dd7 chain D Region: 16 - 33 Aligned: 18 Modelled: 17 Confidence: 41.7% Identity: 33% PDB header:ribosome inhibitor Chain: D: PDB Molecule:prevent host death protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd Phyre2 PDB 2xus chain A Region: 46 - 64 Aligned: 19 Modelled: 19 Confidence: 38.9% Identity: 26% PDB header:protein binding Chain: A: PDB Molecule:breast cancer metastasis-suppressor 1; PDBTitle: crystal structure of the brms1 n-terminal region Phyre2 PDB 2c4m chain A Region: 12 - 74 Aligned: 63 Modelled: 63 Confidence: 35.9% Identity: 13% PDB header:transferase Chain: A: PDB Molecule:glycogen phosphorylase; PDBTitle: starch phosphorylase: structural studies explain oxyanion-2 dependent kinetic stability and regulatory control. Phyre2 PDB 1hx1 chain B Region: 3 - 66 Aligned: 64 Modelled: 64 Confidence: 35.8% Identity: 14% Fold: Spectrin repeat-like Superfamily: BAG domain Family: BAG domain Phyre2 PDB 2ati chain A domain 1 Region: 12 - 74 Aligned: 63 Modelled: 63 Confidence: 34.0% Identity: 14% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 2gj4 chain A domain 1 Region: 12 - 74 Aligned: 63 Modelled: 63 Confidence: 30.2% Identity: 13% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 1i6z chain A Region: 3 - 66 Aligned: 64 Modelled: 64 Confidence: 22.3% Identity: 14% Fold: Spectrin repeat-like Superfamily: BAG domain Family: BAG domain Phyre2 PDB 1l5w chain A Region: 12 - 74 Aligned: 63 Modelled: 63 Confidence: 20.0% Identity: 16% Fold: UDP-Glycosyltransferase/glycogen phosphorylase Superfamily: UDP-Glycosyltransferase/glycogen phosphorylase Family: Oligosaccharide phosphorylase Phyre2 PDB 3he5 chain A Region: 28 - 63 Aligned: 28 Modelled: 36 Confidence: 19.4% Identity: 39% PDB header:de novo protein Chain: A: PDB Molecule:synzip1; PDBTitle: heterospecific coiled-coil pair synzip2:synzip1 Phyre2 PDB 3swf chain A Region: 18 - 48 Aligned: 31 Modelled: 31 Confidence: 17.2% Identity: 19% PDB header:transport protein Chain: A: PDB Molecule:cgmp-gated cation channel alpha-1; PDBTitle: cnga1 621-690 containing clz domain Phyre2 PDB 3bbp chain F Region: 12 - 39 Aligned: 28 Modelled: 28 Confidence: 14.6% Identity: 25% PDB header:protein transport/splicing Chain: F: PDB Molecule:grip and coiled-coil domain-containing protein 2; PDBTitle: rab6-gtp:gcc185 rab binding domain complex Phyre2 PDB 3pxp chain A Region: 3 - 27 Aligned: 24 Modelled: 25 Confidence: 14.2% Identity: 13% PDB header:transcription regulator Chain: A: PDB Molecule:helix-turn-helix domain protein; PDBTitle: crystal structure of a pas and dna binding domain containing protein2 (caur_2278) from chloroflexus aurantiacus j-10-fl at 2.30 a3 resolution Phyre2 PDB 3swy chain B Region: 10 - 35 Aligned: 26 Modelled: 26 Confidence: 13.0% Identity: 23% PDB header:transport protein Chain: B: PDB Molecule:cyclic nucleotide-gated cation channel alpha-3; PDBTitle: cnga3 626-672 containing clz domain Phyre2 PDB 3dd7 chain B Region: 17 - 33 Aligned: 17 Modelled: 16 Confidence: 12.7% Identity: 35% PDB header:ribosome inhibitor Chain: B: PDB Molecule:prevent host death protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd Phyre2 PDB 3nmd chain A Region: 5 - 36 Aligned: 32 Modelled: 30 Confidence: 10.0% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:cgmp dependent protein kinase; PDBTitle: crystal structure of the leucine zipper domain of cgmp dependent2 protein kinase i beta Phyre2 PDB 1xbr chain A Region: 7 - 25 Aligned: 19 Modelled: 19 Confidence: 9.2% Identity: 26% Fold: Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily: p53-like transcription factors Family: T-box Phyre2 1 c1zhcA_ 2 c2a3dA_ 3 c1yybA_ 4 c3ddsB_ 5 c3dd7D_ 6 c2xusA_ 7 c2c4mA_ 8 d1hx1b_ 9 d2atia1 10 d2gj4a1 11 d1i6za_ 12 d1l5wa_ 13 c3he5A_ 14 c3swfA_ 15 c3bbpF_ 16 c3pxpA_ 17 c3swyB_ 18 c3dd7B_ 19 c3nmdA_ 20 d1xbra_ 21 22 23 24 25 26 27 28 29

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1zhcA_ 100.0 47 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein hp1242; PDBTitle: solution structure of hp1242 from helicobacter pylori 2 c2a3dA_ 59.9 14 PDB header:three-helix bundle Chain: A: PDB Molecule:protein (de novo three-helix bundle); PDBTitle: solution structure of a de novo designed single chain three-2 helix bundle (a3d) 3 c1yybA_ 42.1 20 PDB header:apoptosis Chain: A: PDB Molecule:programmed cell death protein 5; PDBTitle: solution structure of 1-26 fragment of human programmed2 cell death 5 protein 4 c3ddsB_ 42.0 14 PDB header:transferase Chain: B: PDB Molecule:glycogen phosphorylase, liver form; PDBTitle: crystal structure of glycogen phosphorylase complexed with an2 anthranilimide based inhibitor gsk261 5 c3dd7D_ 41.7 33 PDB header:ribosome inhibitor Chain: D: PDB Molecule:prevent host death protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd 6 c2xusA_ 38.9 26 PDB header:protein binding Chain: A: PDB Molecule:breast cancer metastasis-suppressor 1; PDBTitle: crystal structure of the brms1 n-terminal region 7 c2c4mA_ 35.9 13 PDB header:transferase Chain: A: PDB Molecule:glycogen phosphorylase; PDBTitle: starch phosphorylase: structural studies explain oxyanion-2 dependent kinetic stability and regulatory control. 8 d1hx1b_ 35.8 14 Fold:Spectrin repeat-like Superfamily:BAG domain Family:BAG domain 9 d2atia1 34.0 14 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Oligosaccharide phosphorylase 10 d2gj4a1 30.2 13 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Oligosaccharide phosphorylase 11 d1i6za_ 22.3 14 Fold:Spectrin repeat-like Superfamily:BAG domain Family:BAG domain 12 d1l5wa_ 20.0 16 Fold:UDP-Glycosyltransferase/glycogen phosphorylase Superfamily:UDP-Glycosyltransferase/glycogen phosphorylase Family:Oligosaccharide phosphorylase 13 c3he5A_ 19.4 39 PDB header:de novo protein Chain: A: PDB Molecule:synzip1; PDBTitle: heterospecific coiled-coil pair synzip2:synzip1 14 c3swfA_ 17.2 19 PDB header:transport protein Chain: A: PDB Molecule:cgmp-gated cation channel alpha-1; PDBTitle: cnga1 621-690 containing clz domain 15 c3bbpF_ 14.6 25 PDB header:protein transport/splicing Chain: F: PDB Molecule:grip and coiled-coil domain-containing protein 2; PDBTitle: rab6-gtp:gcc185 rab binding domain complex 16 c3pxpA_ 14.2 13 PDB header:transcription regulator Chain: A: PDB Molecule:helix-turn-helix domain protein; PDBTitle: crystal structure of a pas and dna binding domain containing protein2 (caur_2278) from chloroflexus aurantiacus j-10-fl at 2.30 a3 resolution 17 c3swyB_ 13.0 23 PDB header:transport protein Chain: B: PDB Molecule:cyclic nucleotide-gated cation channel alpha-3; PDBTitle: cnga3 626-672 containing clz domain 18 c3dd7B_ 12.7 35 PDB header:ribosome inhibitor Chain: B: PDB Molecule:prevent host death protein; PDBTitle: structure of doch66y in complex with the c-terminal domain of phd 19 c3nmdA_ 10.0 16 PDB header:transferase Chain: A: PDB Molecule:cgmp dependent protein kinase; PDBTitle: crystal structure of the leucine zipper domain of cgmp dependent2 protein kinase i beta 20 d1xbra_ 9.2 26 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:p53-like transcription factors Family:T-box 21 c2w6aB_ not modelled 9.1 26 PDB header:signaling protein Chain: B: PDB Molecule:arf gtpase-activating protein git1; PDBTitle: x-ray structure of the dimeric git1 coiled-coil domain 22 d1or7a2 not modelled 8.1 17 Fold:Sigma2 domain of RNA polymerase sigma factors Superfamily:Sigma2 domain of RNA polymerase sigma factors Family:Sigma2 domain of RNA polymerase sigma factors 23 c2kq6A_ not modelled 6.7 19 PDB header:transport protein Chain: A: PDB Molecule:polycystin-2; PDBTitle: the structure of the ef-hand domain of polycystin-2 suggests a2 mechanism for ca2+-dependent regulation of polycystin-2 channel3 activity 24 c3d7iB_ not modelled 5.8 13 PDB header:lyase Chain: B: PDB Molecule:carboxymuconolactone decarboxylase family protein; PDBTitle: crystal structure of carboxymuconolactone decarboxylase family protein2 possibly involved in oxygen detoxification (1591455) from3 methanococcus jannaschii at 1.75 a resolution 25 c1ny9A_ not modelled 5.7 17 PDB header:transcription Chain: A: PDB Molecule:transcriptional activator tipa-s; PDBTitle: antibiotic binding domain of a tipa-class multidrug2 resistance transcriptional regulator 26 d1ny9a_ not modelled 5.7 17 Fold:Antibiotic binding domain of TipA-like multidrug resistance regulators Superfamily:Antibiotic binding domain of TipA-like multidrug resistance regulators Family:Antibiotic binding domain of TipA-like multidrug resistance regulators 27 c2f9jP_ not modelled 5.5 11 PDB header:rna binding protein Chain: P: PDB Molecule:splicing factor 3b subunit 1; PDBTitle: 3.0 angstrom resolution structure of a y22m mutant of the spliceosomal2 protein p14 bound to a region of sf3b155 28 d1or7b2 not modelled 5.3 15 Fold:Sigma2 domain of RNA polymerase sigma factors Superfamily:Sigma2 domain of RNA polymerase sigma factors Family:Sigma2 domain of RNA polymerase sigma factors 29 d1h6fa_ not modelled 5.2 41 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:p53-like transcription factors Family:T-box

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0