Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	D	Y	E	T	L	R	F	I	W	W	L	L	I	G	V	I	L	V	V	F	M	I	S	D	G	F	D	M	G	I	G	C	L	L	P	L	V	A	R	N	D	D	E	R	R	I	V	I	N	S	V	G	A	H	W	E	G	N
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Q	V	W	L	I	L	A	G	G	A	L	F	A	A	W	P	R	V	Y	A	A	A	F	S	G	F	Y	V	A	M	I	L	V	L	C	S	L	F	F	R	P	L	A	F	D	Y	R	G	K	I	A	D	A	R	W	R	K	M	W	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	G	L	V	I	G	S	L	V	P	P	V	V	F	G	I	A	F	G	N	L	L	L	G	V	P	F	A	F	T	P	Q	L	R	V	E	Y	L	G	S	F	W	Q	L	L	T	P	F	P	L	L	C	G	L	L	S	L	G	M	V
Secondary structure
SS confidence
Disorder																												?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	L	Q	G	G	V	W	L	Q	L	K	T	V	G	V	I	H	L	R	S	Q	L	A	T	K	R	A	A	L	L	V	M	L	C	F	L	L	A	G	Y	W	L	W	V	G	I	D	G	F	V	L	L	A	Q	D	A	N	G	P	S
Secondary structure
SS confidence
Disorder																																																			?	?	?			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		N	P	L	M	K	L	V	A	V	L	P	G	A	W	M	N	N	F	V	E	S	P	V	L	W	I	F	P	L	L	G	F	F	C	P	L	L	T	V	M	A	I	Y	R	G	R	P	G	W	G	F	L	M	A	S	L	M	Q	F	G
Secondary structure
SS confidence
Disorder		?	?		?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	I	F	T	A	G	I	T	L	F	P	F	V	M	P	S	S	V	S	P	I	S	S	L	T	L	W	D	S	T	S	S	Q	L	T	L	S	I	M	L	V	I	V	L	I	F	L	P	I	V	L	L	Y	T	L	W	S	Y	Y	K
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.
Sequence		M	W	G	R	M	T	T	E	T	L	R	R	N	E	N	E	L	Y
Secondary structure
SS confidence
Disorder				?			?				?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1qle chain B Region: 322 - 376 Aligned: 55 Modelled: 55 Confidence: 36.5% Identity: 16% PDB header:oxidoreductase/immune system Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: cryo-structure of the paracoccus denitrificans four-subunit2 cytochrome c oxidase in the completely oxidized state3 complexed with an antibody fv fragment Phyre2 PDB 1ar1 chain B Region: 322 - 376 Aligned: 55 Modelled: 55 Confidence: 36.5% Identity: 16% PDB header:complex (oxidoreductase/antibody) Chain: B: PDB Molecule:cytochrome c oxidase; PDBTitle: structure at 2.7 angstrom resolution of the paracoccus2 denitrificans two-subunit cytochrome c oxidase complexed3 with an antibody fv fragment Phyre2 PDB 3m7b chain A Region: 129 - 370 Aligned: 188 Modelled: 197 Confidence: 17.6% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha Phyre2 PDB 1ejx chain C domain 2 Region: 307 - 338 Aligned: 32 Modelled: 32 Confidence: 16.1% Identity: 25% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: alpha-subunit of urease, catalytic domain Phyre2 PDB 1e9y chain B domain 2 Region: 307 - 338 Aligned: 32 Modelled: 32 Confidence: 15.3% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: alpha-subunit of urease, catalytic domain Phyre2 PDB 2r6g chain F domain 2 Region: 76 - 201 Aligned: 125 Modelled: 126 Confidence: 12.6% Identity: 10% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2hku chain A domain 2 Region: 106 - 139 Aligned: 28 Modelled: 34 Confidence: 11.7% Identity: 25% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 2xq2 chain A Region: 3 - 375 Aligned: 295 Modelled: 304 Confidence: 10.7% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 2kta chain A Region: 40 - 58 Aligned: 19 Modelled: 19 Confidence: 8.9% Identity: 21% PDB header:hydrolase Chain: A: PDB Molecule:putative helicase; PDBTitle: solution nmr structure of a domain of protein a6ky75 from bacteroides2 vulgatus, northeast structural genomics target bvr106a Phyre2 PDB 2f3o chain B Region: 42 - 62 Aligned: 21 Modelled: 21 Confidence: 8.0% Identity: 5% PDB header:unknown function Chain: B: PDB Molecule:pyruvate formate-lyase 2; PDBTitle: crystal structure of a glycyl radical enzyme from archaeoglobus2 fulgidus Phyre2 PDB 3fh6 chain F Region: 75 - 287 Aligned: 212 Modelled: 213 Confidence: 7.9% Identity: 9% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2knc chain A Region: 337 - 376 Aligned: 40 Modelled: 40 Confidence: 7.3% Identity: 15% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 3dtu chain B domain 2 Region: 321 - 376 Aligned: 56 Modelled: 56 Confidence: 6.7% Identity: 20% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 2iub chain A domain 2 Region: 333 - 361 Aligned: 29 Modelled: 29 Confidence: 6.2% Identity: 17% Fold: Transmembrane helix hairpin Superfamily: Magnesium transport protein CorA, transmembrane region Family: Magnesium transport protein CorA, transmembrane region Phyre2 PDB 2v5i chain A Region: 52 - 59 Aligned: 8 Modelled: 8 Confidence: 5.9% Identity: 25% PDB header:viral protein Chain: A: PDB Molecule:salmonella typhimurium db7155 bacteriophage det7 PDBTitle: structure of the receptor-binding protein of bacteriophage2 det7: a podoviral tailspike in a myovirus Phyre2 PDB 3hfx chain A Region: 32 - 193 Aligned: 135 Modelled: 148 Confidence: 5.6% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 1 c1qleB_ 2 c1ar1B_ 3 c3m7bA_ 4 d1ejxc2 5 d1e9yb2 6 d2r6gf2 7 d2hkua2 8 c2xq2A_ 9 c2ktaA_ 10 c2f3oB_ 11 c3fh6F_ 12 c2kncA_ 13 d3dtub2 14 d2iuba2 15 c2v5iA_ 16 c3hfxA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c1qleB_ 36.5 16 PDB header:oxidoreductase/immune system Chain: B: PDB Molecule:cytochrome c oxidase polypeptide ii; PDBTitle: cryo-structure of the paracoccus denitrificans four-subunit2 cytochrome c oxidase in the completely oxidized state3 complexed with an antibody fv fragment 2 c1ar1B_ 36.5 16 PDB header:complex (oxidoreductase/antibody) Chain: B: PDB Molecule:cytochrome c oxidase; PDBTitle: structure at 2.7 angstrom resolution of the paracoccus2 denitrificans two-subunit cytochrome c oxidase complexed3 with an antibody fv fragment 3 c3m7bA_ 17.6 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha 4 d1ejxc2 16.1 25 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:alpha-subunit of urease, catalytic domain 5 d1e9yb2 15.3 16 Fold:TIM beta/alpha-barrel Superfamily:Metallo-dependent hydrolases Family:alpha-subunit of urease, catalytic domain 6 d2r6gf2 12.6 10 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 7 d2hkua2 11.7 25 Fold:Tetracyclin repressor-like, C-terminal domain Superfamily:Tetracyclin repressor-like, C-terminal domain Family:Tetracyclin repressor-like, C-terminal domain 8 c2xq2A_ 10.7 13 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 9 c2ktaA_ 8.9 21 PDB header:hydrolase Chain: A: PDB Molecule:putative helicase; PDBTitle: solution nmr structure of a domain of protein a6ky75 from bacteroides2 vulgatus, northeast structural genomics target bvr106a 10 c2f3oB_ 8.0 5 PDB header:unknown function Chain: B: PDB Molecule:pyruvate formate-lyase 2; PDBTitle: crystal structure of a glycyl radical enzyme from archaeoglobus2 fulgidus 11 c3fh6F_ 7.9 9 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 12 c2kncA_ 7.3 15 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 13 d3dtub2 6.7 20 Fold:Transmembrane helix hairpin Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region Family:Cytochrome c oxidase subunit II-like, transmembrane region 14 d2iuba2 6.2 17 Fold:Transmembrane helix hairpin Superfamily:Magnesium transport protein CorA, transmembrane region Family:Magnesium transport protein CorA, transmembrane region 15 c2v5iA_ 5.9 25 PDB header:viral protein Chain: A: PDB Molecule:salmonella typhimurium db7155 bacteriophage det7 PDBTitle: structure of the receptor-binding protein of bacteriophage2 det7: a podoviral tailspike in a myovirus 16 c3hfxA_ 5.6 13 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0