Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	S	T	T	L	F	K	D	F	T	F	E	A	A	H	R	L	P	H	V	P	E	G	H	K	C	G	R	L	H	G	H	S	F	M	V	R	L	E	I	T	G	E	V	D	P	H	T	G	W	I	I	D	F	A	E	L	K	A
Secondary structure
SS confidence
Disorder		?	?	?																			?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	F	K	P	T	Y	E	R	L	D	H	H	Y	L	N	D	I	P	G	L	E	N	P	T	S	E	V	L	A	K	W	I	W	D	Q	V	K	P	V	V	P	L	L	S	A	V	M	V	K	E	T	C	T	A	G	C	I	Y	R	G
Secondary structure
SS confidence
Disorder																																																													?
Disorder confidence
		.
Sequence		E
Secondary structure
SS confidence
Disorder		?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2oba chain E Region: 3 - 121 Aligned: 119 Modelled: 117 Confidence: 100.0% Identity: 75% PDB header:lyase Chain: E: PDB Molecule:probable 6-pyruvoyl tetrahydrobiopterin synthase; PDBTitle: pseudomonas aeruginosa 6-pyruvoyl tetrahydrobiopterin synthase Phyre2 PDB 2g64 chain A domain 1 Region: 1 - 120 Aligned: 120 Modelled: 120 Confidence: 100.0% Identity: 32% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: 6-pyruvoyl tetrahydropterin synthase Phyre2 PDB 1b66 chain A Region: 3 - 121 Aligned: 119 Modelled: 119 Confidence: 100.0% Identity: 33% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: 6-pyruvoyl tetrahydropterin synthase Phyre2 PDB 3jyg chain B Region: 2 - 121 Aligned: 119 Modelled: 120 Confidence: 100.0% Identity: 34% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of uncharacterized protein ws1659 from2 wolinella succinogenes Phyre2 PDB 3d7j chain D Region: 2 - 120 Aligned: 118 Modelled: 117 Confidence: 100.0% Identity: 21% PDB header:unknown function Chain: D: PDB Molecule:uncharacterized protein sco6650; PDBTitle: sco6650, a 6-pyruvoyltetrahydropterin synthase homolog from2 streptomyces coelicolor Phyre2 PDB 2dj6 chain B Region: 2 - 120 Aligned: 112 Modelled: 117 Confidence: 100.0% Identity: 34% PDB header:lyase Chain: B: PDB Molecule:hypothetical protein ph0634; PDBTitle: crystal structure of 6-pyruvoyl tetrahydrobiopterin synthase from2 pyrococcus horikoshii ot3 Phyre2 PDB 2a0s chain A domain 1 Region: 1 - 121 Aligned: 117 Modelled: 121 Confidence: 100.0% Identity: 28% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: 6-pyruvoyl tetrahydropterin synthase Phyre2 PDB 1y13 chain A Region: 2 - 120 Aligned: 115 Modelled: 119 Confidence: 100.0% Identity: 28% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: 6-pyruvoyl tetrahydropterin synthase Phyre2 PDB 2l7e chain A Region: 2 - 49 Aligned: 46 Modelled: 48 Confidence: 58.6% Identity: 4% PDB header:transcription Chain: A: PDB Molecule:transcription initiation factor tfiid subunit 14; PDBTitle: the structure of a domain from yeast Phyre2 PDB 2o90 chain A Region: 2 - 109 Aligned: 90 Modelled: 108 Confidence: 48.8% Identity: 9% PDB header:lyase Chain: A: PDB Molecule:dihydroneopterin aldolase; PDBTitle: atomic resolution crystal structure of e.coli2 dihydroneopterin aldolase in complex with neopterin Phyre2 PDB 1dhn chain A Region: 1 - 109 Aligned: 92 Modelled: 103 Confidence: 48.1% Identity: 18% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: DHN aldolase/epimerase Phyre2 PDB 2cg8 chain B Region: 2 - 109 Aligned: 91 Modelled: 102 Confidence: 45.9% Identity: 20% PDB header:lyase/transferase Chain: B: PDB Molecule:dihydroneopterin aldolase 6-hydroxymethyl-7,8- PDBTitle: the bifunctional dihydroneopterin aldolase 6-hydroxymethyl-2 7,8-dihydropterin synthase from streptococcus pneumoniae Phyre2 PDB 1oao chain C Region: 39 - 108 Aligned: 70 Modelled: 70 Confidence: 31.3% Identity: 24% Fold: Prismane protein-like Superfamily: Prismane protein-like Family: Acetyl-CoA synthase Phyre2 PDB 1yag chain A domain 1 Region: 48 - 96 Aligned: 49 Modelled: 49 Confidence: 29.4% Identity: 12% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Actin/HSP70 Phyre2 PDB 1k8k chain A domain 1 Region: 48 - 96 Aligned: 49 Modelled: 49 Confidence: 21.1% Identity: 22% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Actin/HSP70 Phyre2 PDB 2hf3 chain A domain 1 Region: 48 - 97 Aligned: 50 Modelled: 50 Confidence: 20.8% Identity: 14% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Actin/HSP70 Phyre2 PDB 2fxu chain A domain 1 Region: 48 - 97 Aligned: 50 Modelled: 50 Confidence: 20.1% Identity: 16% Fold: Ribonuclease H-like motif Superfamily: Actin-like ATPase domain Family: Actin/HSP70 Phyre2 PDB 3rhf chain B Region: 31 - 109 Aligned: 69 Modelled: 79 Confidence: 19.4% Identity: 16% PDB header:transferase Chain: B: PDB Molecule:putative polyphosphate kinase 2 family protein; PDBTitle: crystal structure of polyphosphate kinase 2 from arthrobacter2 aurescens tc1 Phyre2 PDB 2ju2 chain A Region: 80 - 96 Aligned: 17 Modelled: 17 Confidence: 19.1% Identity: 12% PDB header:transferase Chain: A: PDB Molecule:erythronolide synthase; PDBTitle: minimized mean solution structure of the acyl carrier2 protein domain from module 2 of 6-deoxyerythronolide b3 synthase (debs) Phyre2 PDB 3git chain A Region: 39 - 109 Aligned: 71 Modelled: 71 Confidence: 18.3% Identity: 24% PDB header:transferase Chain: A: PDB Molecule:carbon monoxide dehydrogenase/acetyl-coa synthase subunit PDBTitle: crystal structure of a truncated acetyl-coa synthase Phyre2 1 c2obaE_ 2 d2g64a1 3 d1b66a_ 4 c3jygB_ 5 c3d7jD_ 6 c2dj6B_ 7 d2a0sa1 8 d1y13a_ 9 c2l7eA_ 10 c2o90A_ 11 d1dhna_ 12 c2cg8B_ 13 d1oaoc_ 14 d1yaga1 15 d1k8ka1 16 d2hf3a1 17 d2fxua1 18 c3rhfB_ 19 c2ju2A_ 20 c3gitA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2obaE_ 100.0 75 PDB header:lyase Chain: E: PDB Molecule:probable 6-pyruvoyl tetrahydrobiopterin synthase; PDBTitle: pseudomonas aeruginosa 6-pyruvoyl tetrahydrobiopterin synthase 2 d2g64a1 100.0 32 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:6-pyruvoyl tetrahydropterin synthase 3 d1b66a_ 100.0 33 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:6-pyruvoyl tetrahydropterin synthase 4 c3jygB_ 100.0 34 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of uncharacterized protein ws1659 from2 wolinella succinogenes 5 c3d7jD_ 100.0 21 PDB header:unknown function Chain: D: PDB Molecule:uncharacterized protein sco6650; PDBTitle: sco6650, a 6-pyruvoyltetrahydropterin synthase homolog from2 streptomyces coelicolor 6 c2dj6B_ 100.0 34 PDB header:lyase Chain: B: PDB Molecule:hypothetical protein ph0634; PDBTitle: crystal structure of 6-pyruvoyl tetrahydrobiopterin synthase from2 pyrococcus horikoshii ot3 7 d2a0sa1 100.0 28 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:6-pyruvoyl tetrahydropterin synthase 8 d1y13a_ 100.0 28 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:6-pyruvoyl tetrahydropterin synthase 9 c2l7eA_ 58.6 4 PDB header:transcription Chain: A: PDB Molecule:transcription initiation factor tfiid subunit 14; PDBTitle: the structure of a domain from yeast 10 c2o90A_ 48.8 9 PDB header:lyase Chain: A: PDB Molecule:dihydroneopterin aldolase; PDBTitle: atomic resolution crystal structure of e.coli2 dihydroneopterin aldolase in complex with neopterin 11 d1dhna_ 48.1 18 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:DHN aldolase/epimerase 12 c2cg8B_ 45.9 20 PDB header:lyase/transferase Chain: B: PDB Molecule:dihydroneopterin aldolase 6-hydroxymethyl-7,8- PDBTitle: the bifunctional dihydroneopterin aldolase 6-hydroxymethyl-2 7,8-dihydropterin synthase from streptococcus pneumoniae 13 d1oaoc_ 31.3 24 Fold:Prismane protein-like Superfamily:Prismane protein-like Family:Acetyl-CoA synthase 14 d1yaga1 29.4 12 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Actin/HSP70 15 d1k8ka1 21.1 22 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Actin/HSP70 16 d2hf3a1 20.8 14 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Actin/HSP70 17 d2fxua1 20.1 16 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Actin/HSP70 18 c3rhfB_ 19.4 16 PDB header:transferase Chain: B: PDB Molecule:putative polyphosphate kinase 2 family protein; PDBTitle: crystal structure of polyphosphate kinase 2 from arthrobacter2 aurescens tc1 19 c2ju2A_ 19.1 12 PDB header:transferase Chain: A: PDB Molecule:erythronolide synthase; PDBTitle: minimized mean solution structure of the acyl carrier2 protein domain from module 2 of 6-deoxyerythronolide b3 synthase (debs) 20 c3gitA_ 18.3 24 PDB header:transferase Chain: A: PDB Molecule:carbon monoxide dehydrogenase/acetyl-coa synthase subunit PDBTitle: crystal structure of a truncated acetyl-coa synthase 21 c3czpA_ not modelled 15.5 18 PDB header:transferase Chain: A: PDB Molecule:putative polyphosphate kinase 2; PDBTitle: crystal structure of putative polyphosphate kinase 2 from pseudomonas2 aeruginosa pa01 22 d1c0fa1 not modelled 14.6 16 Fold:Ribonuclease H-like motif Superfamily:Actin-like ATPase domain Family:Actin/HSP70 23 c2fvgA_ not modelled 14.6 13 PDB header:hydrolase Chain: A: PDB Molecule:endoglucanase; PDBTitle: crystal structure of endoglucanase (tm1049) from thermotoga maritima2 at 2.01 a resolution 24 d1aoza3 not modelled 13.7 67 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 25 d1kyaa3 not modelled 13.5 67 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 26 c1sqlN_ not modelled 12.6 20 PDB header:lyase Chain: N: PDB Molecule:dihydroneopterin aldolase; PDBTitle: crystal structure of 7,8-dihydroneopterin aldolase in2 complex with guanine 27 d2q9oa3 not modelled 11.1 67 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 28 d1b9la_ not modelled 10.8 9 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:DHN aldolase/epimerase 29 d1ru3a_ not modelled 10.3 25 Fold:Prismane protein-like Superfamily:Prismane protein-like Family:Acetyl-CoA synthase 30 d1hfua3 not modelled 9.7 67 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 31 c3qb0C_ not modelled 9.4 10 PDB header:structural protein Chain: C: PDB Molecule:actin-related protein 4; PDBTitle: crystal structure of actin-related protein arp4 from s. cerevisiae2 complexed with atp 32 d1jjca_ not modelled 9.2 22 Fold:Class II aaRS and biotin synthetases Superfamily:Class II aaRS and biotin synthetases Family:Class II aminoacyl-tRNA synthetase (aaRS)-like, catalytic domain 33 c2pe3A_ not modelled 9.1 18 PDB header:hydrolase Chain: A: PDB Molecule:354aa long hypothetical operon protein frv; PDBTitle: crystal structure of frv operon protein frvx (ph1821)from pyrococcus2 horikoshii ot3 34 d1td6a_ not modelled 9.0 19 Fold:Hypothetical protein MPN330 Superfamily:Hypothetical protein MPN330 Family:Hypothetical protein MPN330 35 d2h1ta1 not modelled 9.0 33 Fold:Spiral beta-roll Superfamily:PA1994-like Family:PA1994-like 36 d1sqla_ not modelled 8.6 20 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:DHN aldolase/epimerase 37 d1gyca3 not modelled 8.1 67 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 38 c3czqA_ not modelled 7.5 14 PDB header:transferase Chain: A: PDB Molecule:putative polyphosphate kinase 2; PDBTitle: crystal structure of putative polyphosphate kinase 2 from2 sinorhizobium meliloti 39 c3sqgF_ not modelled 7.5 33 PDB header:transferase Chain: F: PDB Molecule:methyl-coenzyme m reductase, gamma subunit; PDBTitle: crystal structure of a methyl-coenzyme m reductase purified from black2 sea mats 40 c2afdA_ not modelled 7.4 31 PDB header:ligand binding protein Chain: A: PDB Molecule:protein asl1650; PDBTitle: solution structure of asl1650, an acyl carrier protein from anabaena2 sp. pcc 7120 with a variant phosphopantetheinylation-site sequence 41 d1nbua_ not modelled 6.9 18 Fold:T-fold Superfamily:Tetrahydrobiopterin biosynthesis enzymes-like Family:DHN aldolase/epimerase 42 d1hbnc_ not modelled 6.9 39 Fold:Ferredoxin-like Superfamily:Methyl-coenzyme M reductase subunits Family:Methyl-coenzyme M reductase gamma chain 43 d2gdwa1 not modelled 6.5 31 Fold:Acyl carrier protein-like Superfamily:ACP-like Family:Peptidyl carrier domain 44 c1zpuE_ not modelled 6.5 56 PDB header:oxidoreductase Chain: E: PDB Molecule:iron transport multicopper oxidase fet3; PDBTitle: crystal structure of fet3p, a multicopper oxidase that functions in2 iron import 45 c1zvbC_ not modelled 6.2 24 PDB header:viral protein Chain: C: PDB Molecule:e2 glycoprotein; PDBTitle: a structure-based mechanism of sars virus membrane fusion 46 d1e6yc_ not modelled 6.0 39 Fold:Ferredoxin-like Superfamily:Methyl-coenzyme M reductase subunits Family:Methyl-coenzyme M reductase gamma chain 47 c2gejA_ not modelled 5.7 14 PDB header:transferase Chain: A: PDB Molecule:phosphatidylinositol mannosyltransferase (pima); PDBTitle: crystal structure of phosphatidylinositol mannosyltransferase (pima)2 from mycobacterium smegmatis in complex with gdp-man 48 c1b70A_ not modelled 5.6 22 PDB header:ligase Chain: A: PDB Molecule:phenylalanyl-trna synthetase; PDBTitle: phenylalanyl trna synthetase complexed with phenylalanine 49 c2ihr1_ not modelled 5.5 29 PDB header:translation Chain: 1: PDB Molecule:peptide chain release factor 2; PDBTitle: rf2 of thermus thermophilus 50 d1v10a3 not modelled 5.3 67 Fold:Cupredoxin-like Superfamily:Cupredoxins Family:Multidomain cupredoxins 51 d1e6vc_ not modelled 5.3 28 Fold:Ferredoxin-like Superfamily:Methyl-coenzyme M reductase subunits Family:Methyl-coenzyme M reductase gamma chain 52 c3abgA_ not modelled 5.2 33 PDB header:oxidoreductase Chain: A: PDB Molecule:bilirubin oxidase; PDBTitle: x-ray crystal analysis of bilirubin oxidase from myrothecium2 verrucaria at 2.3 angstrom resolution using a twin crystal

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0