BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (121 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_P65871 6-carboxy-5,6,7,8-tetrahydropterin synthase n=10...   254   5e-67
UniRef50_Q8K9D8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=21...   182   2e-45
UniRef50_A0PNB2 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   160   8e-39
UniRef50_B2IGN7 Queuosine biosynthesis protein QueD n=4 Tax=Rhiz...   140   1e-32
UniRef50_A6EFM8 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   139   3e-32
UniRef50_B3DVJ6 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bac...   131   8e-30
UniRef50_Q6MLY9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdel...   129   4e-29
UniRef50_C5SC00 Putative uncharacterized protein n=1 Tax=Allochr...   119   4e-26
UniRef50_Q7NSB8 Probable 6-pyruvoyltetrahydrobiopterin synthase ...   114   1e-24
UniRef50_C6QCT4 Putative uncharacterized protein n=1 Tax=Hyphomi...   114   1e-24
UniRef50_B9Z1F8 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Nei...   112   4e-24
UniRef50_B5JVD7 Probable 6-pyruvoyltetrahydrobiopterin synthase ...   110   1e-23
UniRef50_UPI0001C165E4 Dihydropteroate synthase n=1 Tax=Raphidio...   104   7e-22
UniRef50_B7K1S3 Queuosine biosynthesis protein QueD n=6 Tax=Cyan...   104   8e-22
UniRef50_C6QGG4 Queuosine biosynthesis protein QueD n=1 Tax=Hyph...   102   4e-21
UniRef50_A1WW30 Putative uncharacterized protein n=1 Tax=Halorho...   101   7e-21
UniRef50_A7HXX3 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Par...   100   1e-20
UniRef50_Q55798 6-carboxy-5,6,7,8-tetrahydropterin synthase n=7 ...    99   3e-20
UniRef50_A3UD70 6-pyruvoyl tetrahydrobiopterin synthase, putativ...    92   4e-18
UniRef50_B6CWI6 ToyB n=5 Tax=Bacteria RepID=B6CWI6_STRRM               92   6e-18
UniRef50_Q3SPB8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Alp...    87   1e-16
UniRef50_A2SD50 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    87   2e-16
UniRef50_A4XG23 Putative uncharacterized protein n=4 Tax=Bacteri...    86   3e-16
UniRef50_Q0BPQ0 Queuosine biosynthesis protein queD n=2 Tax=Prot...    84   2e-15
UniRef50_Q2IJB0 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Ana...    83   3e-15
UniRef50_Q2K3W9 6-pyruvoyl tetrahydropterin synthase protein n=1...    82   6e-15
UniRef50_B9K796 Queuosine biosynthesis protein QueD n=2 Tax=Bact...    80   2e-14
UniRef50_A8L9C2 Putative uncharacterized protein n=1 Tax=Frankia...    80   2e-14
UniRef50_D0B3L9 6-pyruvoyl tetrahydrobiopterin synthase n=47 Tax...    80   2e-14
UniRef50_D0Y1P4 6-pyruvoyl tetrahydropterin synthase n=3 Tax=cel...    80   2e-14
UniRef50_Q0RM63 6-pyruvoyl tetrahydrobiopterin synthase n=11 Tax...    79   4e-14
UniRef50_B0SX52 Queuosine biosynthesis protein QueD n=1 Tax=Caul...    79   5e-14
UniRef50_B4RHW0 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...    78   1e-13
UniRef50_D0J5V8 6-pyruvoyl tetrahydropterin synthase and n=7 Tax...    78   1e-13
UniRef50_C0GP47 Queuosine biosynthesis protein QueD n=1 Tax=Desu...    77   1e-13
UniRef50_A3VUJ4 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...    77   1e-13
UniRef50_D2L9S0 Putative uncharacterized protein n=1 Tax=Desulfo...    76   3e-13
UniRef50_A6GQ16 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    74   1e-12
UniRef50_B5YCT3 6-pyruvoyl-tetrahydropterin synthase n=24 Tax=Ba...    74   1e-12
UniRef50_A9AWJ6 Putative uncharacterized protein n=1 Tax=Herpeto...    73   2e-12
UniRef50_C4XPJ5 6-pyruvoyl tetrahydropterin synthase family prot...    71   1e-11
UniRef50_C9LTT9 Queuosine biosynthesis protein QueD n=3 Tax=Bact...    71   1e-11
UniRef50_C9RBW1 Putative uncharacterized protein n=1 Tax=Ammonif...    71   1e-11
UniRef50_O31676 6-carboxy-5,6,7,8-tetrahydropterin synthase n=85...    70   2e-11
UniRef50_C1TQH0 PreQ(0) biosynthesis protein QueD n=2 Tax=Bacter...    69   4e-11
UniRef50_B5Y6S0 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Bac...    69   5e-11
UniRef50_C9KKI2 Queuosine biosynthesis protein QueD n=2 Tax=Veil...    68   7e-11
UniRef50_Q1IHK8 Putative uncharacterized protein n=3 Tax=Acidoba...    68   9e-11
UniRef50_B8J0W0 Queuosine biosynthesis protein QueD n=8 Tax=Desu...    68   1e-10
UniRef50_Q3ADI6 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    67   2e-10
UniRef50_B0VJG6 6-pyruvoyl tetrahydrobiopterin synthase family p...    67   2e-10
UniRef50_Q3B4V1 6-pyruvoyltetrahydropterin synthase n=11 Tax=Chl...    66   3e-10
UniRef50_B5W8I5 Putative uncharacterized protein n=3 Tax=Cyanoba...    66   4e-10
UniRef50_D1B660 Putative uncharacterized protein n=1 Tax=Therman...    65   6e-10
UniRef50_B5YJJ7 6-pyruvoyl-tetrahydropterin synthase n=4 Tax=Bac...    65   6e-10
UniRef50_C8VWH9 Putative uncharacterized protein n=1 Tax=Desulfo...    65   8e-10
UniRef50_B9ZMJ4 Queuosine biosynthesis protein QueD n=1 Tax=Thio...    65   9e-10
UniRef50_Q63E30 6-pyruvoyl tetrahydrobiopterin synthase n=100 Ta...    64   1e-09
UniRef50_C4V0R8 Possible 6-pyruvoyltetrahydropterin synthase n=1...    64   1e-09
UniRef50_C7HJ58 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Clo...    64   2e-09
UniRef50_Q2IKV5 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Ana...    64   2e-09
UniRef50_Q31FT9 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...    64   2e-09
UniRef50_C0QLV0 PtpS n=8 Tax=cellular organisms RepID=C0QLV0_DESAH     63   2e-09
UniRef50_A1SFN0 Putative uncharacterized protein n=1 Tax=Nocardi...    63   4e-09
UniRef50_B1ZTR4 Putative uncharacterized protein n=3 Tax=Bacteri...    62   4e-09
UniRef50_Q1ZXI0 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...    62   7e-09
UniRef50_Q03393 6-pyruvoyl tetrahydrobiopterin synthase n=19 Tax...    62   8e-09
UniRef50_Q1NNH1 Putative uncharacterized protein n=2 Tax=delta p...    62   8e-09
UniRef50_O29809 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    61   1e-08
UniRef50_B8DNN3 Putative uncharacterized protein n=3 Tax=Desulfo...    60   2e-08
UniRef50_Q2LVK6 Queuosine biosynthesis protein n=1 Tax=Syntrophu...    60   2e-08
UniRef50_Q46G73 6-pyruvoyltetrahydropterin synthase n=7 Tax=Eury...    60   2e-08
UniRef50_Q30ZA2 6-pyruvoyl tetrahydrobiopterin synthase, putativ...    60   3e-08
UniRef50_C5A6K8 6-pyruvoyl tetrahydrobiopterin synthase (PtpS) n...    59   4e-08
UniRef50_P48611 6-pyruvoyl tetrahydrobiopterin synthase n=16 Tax...    59   5e-08
UniRef50_A1HNF1 Putative uncharacterized protein n=1 Tax=Thermos...    59   6e-08
UniRef50_A0B6A5 Putative uncharacterized protein n=1 Tax=Methano...    59   6e-08
UniRef50_C1CXM4 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    58   1e-07
UniRef50_A0L5B3 Putative uncharacterized protein n=1 Tax=Magneto...    58   1e-07
UniRef50_C8R1L5 Putative uncharacterized protein n=1 Tax=Desulfu...    58   1e-07
UniRef50_C7QN33 6-pyruvoyltetrahydropterin synthase n=3 Tax=Cyan...    58   1e-07
UniRef50_C1SPF1 PreQ(0) biosynthesis protein QueD n=1 Tax=Denitr...    58   1e-07
UniRef50_B2KC64 Putative uncharacterized protein n=1 Tax=Elusimi...    57   1e-07
UniRef50_A5D2E2 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Pep...    57   2e-07
UniRef50_A6LBJ5 6-pyruvoyl-tetrahydropterin synthase n=43 Tax=Ba...    57   2e-07
UniRef50_A3EQ19 Probable 6-pyruvoyl tetrahydrobiopterin synthase...    57   2e-07
UniRef50_B3T9P1 Putative 6-pyruvoyl tetrahydropterin synthase n=...    57   2e-07
UniRef50_Q6ARY1 Related to 6-pyruvoyl tetrahydropterin synthase ...    56   3e-07
UniRef50_C6VZC4 Putative uncharacterized protein n=3 Tax=Sphingo...    56   3e-07
UniRef50_UPI0001B56D65 putative 6-pyruvoyl tetrahydropterin synt...    56   3e-07
UniRef50_A7BS03 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Beg...    56   3e-07
UniRef50_Q3ZW85 6-pyruvoyl tetrahydrobiopterin synthase n=5 Tax=...    56   3e-07
UniRef50_B8FMW4 Queuosine biosynthesis protein QueD n=3 Tax=Prot...    56   3e-07
UniRef50_UPI0001B56179 putative 6-pyruvoyl tetrahydropterin synt...    56   4e-07
UniRef50_D2ML00 Putative uncharacterized protein (Fragment) n=1 ...    55   5e-07
UniRef50_D1JB18 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    55   6e-07
UniRef50_Q979P1 Putative uncharacterized protein TVG1150731 n=2 ...    55   8e-07
UniRef50_Q8Z0L1 Alr0080 protein n=5 Tax=Cyanobacteria RepID=Q8Z0...    55   9e-07
UniRef50_Q3J9J8 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Chr...    55   1e-06
UniRef50_A2BZT2 6-pyruvoyl tetrahydropterin synthase n=48 Tax=ce...    54   1e-06
UniRef50_A3ZTI8 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...    54   1e-06
UniRef50_B0TFF5 6-pyruvoyl-tetrahydropterin synthase, putative n...    54   2e-06
UniRef50_B1GYR9 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    53   2e-06
UniRef50_Q90W95 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...    53   3e-06
UniRef50_O02058 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    53   3e-06
UniRef50_C0N3T5 6-pyruvoyl tetrahydropterin synthase superfamily...    53   4e-06
UniRef50_Q8TX57 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Met...    52   4e-06
UniRef50_UPI0001C1695B hypothetical protein CRD_00116 n=2 Tax=No...    52   4e-06
UniRef50_B5I9Q5 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...    52   6e-06
UniRef50_A8Y1U6 C. briggsae CBR-PTPS-1 protein n=2 Tax=Caenorhab...    52   7e-06
UniRef50_Q6B324 6-pyruvoyl tetrahydropterin synthase (Fragment) ...    52   7e-06
UniRef50_Q3A420 6-pyruvoyl-tetrahydropterin synthase n=7 Tax=Bac...    52   8e-06
UniRef50_UPI0001C418E1 queuosine biosynthesis protein QueD n=1 T...    52   8e-06
UniRef50_UPI000038E306 6-pyruvoyltetrahydrobiopterin synthase n=...    51   9e-06
UniRef50_B9EM09 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=...    51   1e-05
UniRef50_D1NB55 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Vic...    51   1e-05
UniRef50_C1DVU3 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=...    51   1e-05
UniRef50_P44123 6-carboxy-5,6,7,8-tetrahydropterin synthase n=31...    51   1e-05
UniRef50_Q2PY17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bac...    50   2e-05
UniRef50_A0M3Y1 Conserved tetrahydrobiopterin biosynthesis-like ...    50   2e-05
UniRef50_Q7UGM2 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...    50   2e-05
UniRef50_O66626 6-carboxy-5,6,7,8-tetrahydropterin synthase n=8 ...    50   3e-05
UniRef50_C1AB96 6-pyruvoyl tetrahydropterin synthase family prot...    49   3e-05
UniRef50_D0MDN2 Putative uncharacterized protein n=1 Tax=Rhodoth...    49   5e-05
UniRef50_Q6L053 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=P...    49   5e-05
UniRef50_B8G7W6 Putative 6-pyruvoyl tetrahydropterin synthase n=...    49   6e-05
UniRef50_UPI00016C4ECA 6-pyruvoyl tetrahydrobiopterin synthase n...    49   6e-05
UniRef50_C1A6G1 6-pyruvoyl tetrahydropterin synthase family prot...    49   6e-05
UniRef50_D1X5B9 6-pyruvoyl-tetrahydropterin synthase-like protei...    48   7e-05
UniRef50_O27296 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    48   1e-04
UniRef50_B3QUQ1 Putative uncharacterized protein n=1 Tax=Chloroh...    48   1e-04
UniRef50_Q1IPI9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Aci...    47   2e-04
UniRef50_Q6AKY1 Related to 6-pyruvoyl-tetrahydropterin synthase ...    47   2e-04
UniRef50_B2UBF2 Queuosine biosynthesis protein QueD n=85 Tax=cel...    46   3e-04
UniRef50_Q675S7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...    46   3e-04
UniRef50_Q7UMI8 Putative uncharacterized protein n=2 Tax=Plancto...    46   3e-04
UniRef50_C6KTB6 6-pyruvoyltetrahydropterin synthase n=6 Tax=Plas...    46   4e-04
UniRef50_A0RWH6 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Arc...    46   5e-04
UniRef50_A8G2B1 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Cya...    45   5e-04
UniRef50_Q604L2 Putative 6-pyruvoyl tetrahydropterin synthase n=...    45   6e-04
UniRef50_D1CA69 Putative uncharacterized protein n=1 Tax=Sphaero...    45   8e-04
UniRef50_Q1IPJ0 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Can...    45   8e-04
UniRef50_C1ZCI0 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Pla...    45   9e-04
UniRef50_Q04S36 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Lep...    44   0.001
UniRef50_A2STX2 6-pyruvoyl-tetrahydropterin synthase-like protei...    44   0.001
UniRef50_C1YMA8 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Noc...    44   0.002
UniRef50_Q5KZY1 6-pyruvoyltetrahydropterin synthase(PTP synthase...    43   0.003
UniRef50_Q4LA59 Similar to 6-pyruvoyl tetrahydropterin synthase ...    43   0.003
UniRef50_C1VD01 PreQ(0) biosynthesis protein QueD n=1 Tax=Haloge...    43   0.003
UniRef50_A9M1Z1 6-pyruvoyl tetrahydrobiopterin synthase, putativ...    43   0.003
UniRef50_A4FWS8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Met...    43   0.004
UniRef50_A2BJ89 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Hyp...    42   0.004
UniRef50_B2HZD9 6-pyruvoyl-tetrahydropterin synthase n=31 Tax=Pr...    42   0.006
UniRef50_Q1NNT9 Putative uncharacterized protein n=2 Tax=delta p...    42   0.007
UniRef50_B8HQA0 Putative uncharacterized protein n=1 Tax=Cyanoth...    42   0.008
UniRef50_D2QJ42 Putative uncharacterized protein n=1 Tax=Spiroso...    41   0.009
UniRef50_D0MWX1 Putative uncharacterized protein n=2 Tax=Phytoph...    41   0.011
UniRef50_C3KVW1 Queuosine biosynthesis protein QueD n=22 Tax=Bac...    41   0.014
UniRef50_Q0KAE6 6-Pyruvoyl tetrahydrobiopterin synthase protein ...    41   0.014
UniRef50_Q9HHN6 Vng6306c n=3 Tax=Halobacteriaceae RepID=Q9HHN6_H...    40   0.028
UniRef50_O59602 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    40   0.029
UniRef50_C1ZE85 PreQ(0) biosynthesis protein QueD n=2 Tax=Planct...    40   0.032
UniRef50_B2KCS0 Putative uncharacterized protein n=1 Tax=Elusimi...    39   0.037
UniRef50_UPI0001B4C1FC hypothetical protein ShygA5_47370 n=1 Tax...    39   0.048
UniRef50_Q4JIS7 Putative 6-pyruvoyl tetrahydropterin synthase n=...    39   0.053
UniRef50_B6KR79 Putative uncharacterized protein n=3 Tax=Toxopla...    39   0.068
UniRef50_Q18HJ5 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n...    39   0.070
UniRef50_UPI0001C378A0 6-pyruvoyl tetrahydrobiopterin synthase n...    38   0.087

>UniRef50_P65871 6-carboxy-5,6,7,8-tetrahydropterin synthase n=102
           Tax=Proteobacteria RepID=QUED_ECO57
          Length = 121

 Score =  254 bits (649), Expect = 5e-67,   Method: Compositional matrix adjust.
 Identities = 121/121 (100%), Positives = 121/121 (100%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA
Sbjct: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG
Sbjct: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120

Query: 121 E 121
           E
Sbjct: 121 E 121


>UniRef50_Q8K9D8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=210 Tax=Bacteria
           RepID=QUED_BUCAP
          Length = 120

 Score =  182 bits (463), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 77/119 (64%), Positives = 101/119 (84%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M T +FKDF FEAAH LP+VP+ HKC RLHGHSF VRLE+  +++   GWIID+AE+K A
Sbjct: 1   MKTIIFKDFQFEAAHYLPYVPKMHKCRRLHGHSFFVRLELKDKINEKNGWIIDYAEIKLA 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           F+P Y++LDHH+LNDIPGLENPTSE+LAKWIW ++KP + +L+ +++KETCT+GCIY+G
Sbjct: 61  FQPIYDQLDHHFLNDIPGLENPTSEILAKWIWHRLKPKLSILNTIIIKETCTSGCIYQG 119


>UniRef50_A0PNB2 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Mycobacterium
           RepID=A0PNB2_MYCUA
          Length = 160

 Score =  160 bits (406), Expect = 8e-39,   Method: Compositional matrix adjust.
 Identities = 72/122 (59%), Positives = 94/122 (77%), Gaps = 2/122 (1%)

Query: 1   MMSTT-LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
           MM T  ++ +FTFE+AHRLP+VP GHKCGRLHGHS+  R  + G VDP  GWI+DF ++K
Sbjct: 1   MMDTAEIYCEFTFESAHRLPNVPAGHKCGRLHGHSYRARTYVEGPVDPRAGWIVDFGKIK 60

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-LLSAVMVKETCTAGCIY 118
            A KP   RLDH+YLN+I GLENPTSE L+ WIW ++  ++P ++SAV V ETC++GC+Y
Sbjct: 61  DACKPVIARLDHYYLNEIDGLENPTSEQLSMWIWRELATLLPMMMSAVSVSETCSSGCMY 120

Query: 119 RG 120
           RG
Sbjct: 121 RG 122


>UniRef50_B2IGN7 Queuosine biosynthesis protein QueD n=4 Tax=Rhizobiales
           RepID=B2IGN7_BEII9
          Length = 117

 Score =  140 bits (354), Expect = 1e-32,   Method: Compositional matrix adjust.
 Identities = 66/113 (58%), Positives = 82/113 (72%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           + F FEAAHRLP VPEGH+C  LHGHS+ V L + G VDP TG++IDF +++A F P   
Sbjct: 5   QAFHFEAAHRLPKVPEGHRCANLHGHSYRVELYLEGPVDPDTGFVIDFFDIEAVFGPLLH 64

Query: 68  RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           RLDHHYLN+I GLENPT+E++A WIWD+VKP +P L  V+V ET      Y G
Sbjct: 65  RLDHHYLNEIEGLENPTAELIAVWIWDRVKPSLPQLVKVIVYETPDCWAEYEG 117


>UniRef50_A6EFM8 6-pyruvoyl tetrahydrobiopterin synthase, putative n=2 Tax=Bacteria
           RepID=A6EFM8_9SPHI
          Length = 117

 Score =  139 bits (350), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 58/115 (50%), Positives = 82/115 (71%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           ++K F+F++AH LP VP  HKCGR+HGH++ + + ++G  DPH+GW+ DF +LK   +P 
Sbjct: 3   IYKKFSFDSAHYLPLVPASHKCGRMHGHTYQLTVYLSGTPDPHSGWVADFGDLKRGIQPF 62

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            + LDH  LNDIPGLENPTSE L+ W+W ++KPV P L+ + + ET   G IY G
Sbjct: 63  VDLLDHRLLNDIPGLENPTSENLSVWLWQKIKPVFPALAKIELSETPGTGVIYEG 117


>UniRef50_B3DVJ6 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bacteria
           RepID=B3DVJ6_METI4
          Length = 161

 Score =  131 bits (329), Expect = 8e-30,   Method: Compositional matrix adjust.
 Identities = 60/120 (50%), Positives = 77/120 (64%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L KDF FEAA  LP  PEGHKC R HGHSF + + + GEVDP  G + D  ++  A
Sbjct: 42  MHVILSKDFDFEAAQALPSFPEGHKCRRTHGHSFKLTVSVRGEVDPQKGVLYDHGKISEA 101

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
             P  E+LDH+YLNDI GL NPT E +A W W+++K  +P L  + ++ET    CIYRG+
Sbjct: 102 VCPLIEQLDHYYLNDIEGLSNPTIENMAGWFWNKLKDKLPGLYEITIQETARTRCIYRGD 161


>UniRef50_Q6MLY9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLY9_BDEBA
          Length = 135

 Score =  129 bits (323), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 55/117 (47%), Positives = 79/117 (67%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L + F  E+A  LPH+P  H C R+HGHSF + L + G++DP  GW+ID+ +++A 
Sbjct: 16  MKFELKQHFQIESARFLPHLPASHPCSRMHGHSFKLILTLVGDLDPKIGWVIDYNDIQAL 75

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
            KP  +++DH  LN++PGLENPTSE+LAKW++D+ +P +P L  V V ET    C Y
Sbjct: 76  MKPLLDQIDHRVLNEVPGLENPTSELLAKWLYDKARPFLPTLVKVTVAETPATECSY 132


>UniRef50_C5SC00 Putative uncharacterized protein n=1 Tax=Allochromatium vinosum DSM
           180 RepID=C5SC00_CHRVI
          Length = 364

 Score =  119 bits (297), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 61/115 (53%), Positives = 76/115 (66%), Gaps = 1/115 (0%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           L++ F FE+AHRLP+VPEGH CGR+HGH F V L    ++       IDF  L A + P 
Sbjct: 123 LWRRFRFESAHRLPNVPEGHPCGRMHGHGFEVILHADQDLGGQD-MGIDFDRLAALWTPL 181

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           ++ L    LNDIPGLENPTSE L+ WIW ++KP +P LS V V ET TAGC + G
Sbjct: 182 HDELHQVCLNDIPGLENPTSERLSSWIWSRLKPELPALSWVTVYETATAGCHFDG 236



 Score = 92.0 bits (227), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 44/110 (40%), Positives = 68/110 (61%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           ++K+  FEAA RL   PEG    RLHGHS+++RL +T  +D   GW +D+ ++K  FKP 
Sbjct: 241 IWKEQRFEAALRLERSPEGDARRRLHGHSYLLRLHLTAPLDQVLGWTVDYGDVKRLFKPL 300

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAG 115
           Y+RLDHH L+ + GLE      L +WI ++++  +P L  + ++ T   G
Sbjct: 301 YDRLDHHRLDALDGLEAADPGSLIRWIRERIQDDLPELDRIDLQPTPGCG 350



 Score = 62.8 bits (151), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 48/127 (37%), Positives = 67/127 (52%), Gaps = 18/127 (14%)

Query: 2   MSTTLF--KDFTFEAAHRLPHVPEGHKCGRLHGHSFM--VRLEITGEVDPHTGWI----I 53
           M+  LF      FEAA R+  +PEGH+C RLHGHSF+  VR E+        GW      
Sbjct: 1   MNARLFHLAAVPFEAACRVDILPEGHRCRRLHGHSFLAQVRAELP------LGWAGFPGA 54

Query: 54  DFAELKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCT 113
           +  +L+AA     E LD+  LN I  L  PT E LA+W+ D++   VP +++V ++ T  
Sbjct: 55  ESDDLQAALACCVEPLDYRDLNAI--LPIPTDENLARWVRDRLD--VPGIASVGIQSTRD 110

Query: 114 AGCIYRG 120
            G    G
Sbjct: 111 QGADLDG 117


>UniRef50_Q7NSB8 Probable 6-pyruvoyltetrahydrobiopterin synthase n=1
           Tax=Chromobacterium violaceum RepID=Q7NSB8_CHRVO
          Length = 239

 Score =  114 bits (284), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 60/116 (51%), Positives = 75/116 (64%), Gaps = 17/116 (14%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFA-----ELKAAFKPT 65
           +FEAAH LPHVP GHKCGRLHGH F VR+            + D A     EL  A+ P 
Sbjct: 15  SFEAAHHLPHVPPGHKCGRLHGHGFGVRI------------VADAAQCGQRELARAWAPL 62

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
           + RL+HHYLNDI GL+NPTSEVLA+W+  Q+   VP L+ V V+ET +AG  + G+
Sbjct: 63  HRRLNHHYLNDIAGLDNPTSEVLAQWLHQQLSDAVPGLAWVEVRETHSAGSQFDGK 118



 Score = 82.0 bits (201), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 41/111 (36%), Positives = 69/111 (62%), Gaps = 6/111 (5%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           ++K+  FE+A  +P   +G+  G    HS++VRL ++G +D   GW++DF ++K  FKP 
Sbjct: 122 IWKEQRFESA--IPFDADGNYTG----HSYLVRLMLSGGIDRTMGWLLDFGDVKDRFKPI 175

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGC 116
           Y +LDH+ L+ + G+    S  +A+WI  Q+ P+VP LS + + E+  AG 
Sbjct: 176 YRQLDHNPLDKLAGVRGADSAAVAEWIHAQLSPLVPELSRIDLMESDDAGV 226


>UniRef50_C6QCT4 Putative uncharacterized protein n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCT4_9RHIZ
          Length = 140

 Score =  114 bits (284), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 56/119 (47%), Positives = 73/119 (61%), Gaps = 1/119 (0%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           +  ++KDF FEAAH LP    G    R+HGHSF  R+ + GE    TG+I  F EL +A 
Sbjct: 12  AMQIYKDFRFEAAHFLPSAAPGTPNARVHGHSFRARVVVEGEPGRDTGYIFHFDELSSAL 71

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYRG 120
           + T E LDH  LNDI GL  PT E +A WIW+++   VP L  V V +++C  GC+YRG
Sbjct: 72  RETEEDLDHRMLNDIEGLSAPTLERIAMWIWNRLSNRVPGLVQVEVHRDSCNEGCVYRG 130


>UniRef50_B9Z1F8 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Neisseriaceae
           RepID=B9Z1F8_9NEIS
          Length = 341

 Score =  112 bits (279), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 58/110 (52%), Positives = 71/110 (64%), Gaps = 7/110 (6%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           FEAAH+LPHVP GHKCGRLHGH F VRL        H        +L AA+   + RL+H
Sbjct: 118 FEAAHQLPHVPAGHKCGRLHGHGFGVRLVADAASANHV-------DLAAAWGRLFLRLNH 170

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
            YLNDIPGL NPTSEVLA+WI+ ++   +  L+ V V+ET TAG  + G 
Sbjct: 171 RYLNDIPGLANPTSEVLAQWIYRELSADLAGLAWVEVRETHTAGSQFDGR 220



 Score = 75.5 bits (184), Expect = 5e-13,   Method: Compositional matrix adjust.
 Identities = 33/89 (37%), Positives = 55/89 (61%)

Query: 28  GRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLENPTSEV 87
           G   GHS+++RL + GE+D   GW++DF ++K  FKP Y +LDH+ L+ + G+ N     
Sbjct: 240 GNYTGHSYLIRLMLQGELDGAMGWLLDFGDVKDRFKPVYRQLDHNPLDRLAGIRNGHPAS 299

Query: 88  LAKWIWDQVKPVVPLLSAVMVKETCTAGC 116
           +A+W+  ++ P+VP L+ V + E    G 
Sbjct: 300 VAEWVHAELSPLVPELARVDLMERDERGV 328


>UniRef50_B5JVD7 Probable 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=gamma
           proteobacterium HTCC5015 RepID=B5JVD7_9GAMM
          Length = 332

 Score =  110 bits (275), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 62/121 (51%), Positives = 77/121 (63%), Gaps = 8/121 (6%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M  +  ++ + FEAAH LP+VPEGHKCGRLHGH F V L     + P   W  +   L  
Sbjct: 96  MGDSYQWRRYRFEAAHFLPNVPEGHKCGRLHGHGFEVTL-----LAP-LRWSAE--SLDE 147

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            ++P YERL  H LN I GLENPTSEVLA+WIW Q+   +  L +V V+ET TAGC Y G
Sbjct: 148 HWQPLYERLHGHCLNRIVGLENPTSEVLAEWIWRQLIDSITDLLSVDVRETVTAGCRYDG 207

Query: 121 E 121
           +
Sbjct: 208 Q 208



 Score = 64.3 bits (155), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 30/86 (34%), Positives = 47/86 (54%)

Query: 32  GHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKW 91
           GHS+ VRL +   +D   GW  D+ ++K  F+P Y +LDHH LN+I     P+   +A+W
Sbjct: 232 GHSYRVRLHLEAPLDKVMGWTQDYGDVKTQFQPLYRQLDHHCLNEILPSGEPSDLAVAEW 291

Query: 92  IWDQVKPVVPLLSAVMVKETCTAGCI 117
           +   +   +P L+ + V  T   G I
Sbjct: 292 LRQGLGEALPALNRIDVHSTPEEGAI 317


>UniRef50_UPI0001C165E4 Dihydropteroate synthase n=1 Tax=Raphidiopsis brookii D9
           RepID=UPI0001C165E4
          Length = 450

 Score =  104 bits (260), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 52/116 (44%), Positives = 76/116 (65%), Gaps = 7/116 (6%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAELKAAFK 63
           K+F FEAAH+LP+     KC RLH HS+   + + G+   ++G     I+D+ ++    K
Sbjct: 325 KEFRFEAAHQLPN--HDGKCARLHDHSWRGVVYVAGDKLINSGVKQGMIMDYGDISKYIK 382

Query: 64  PTYER-LDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
           P  E  LDH++LN+  GL NPTSE +AKWI++Q++P +P L AV + ETCT+ CIY
Sbjct: 383 PLLENYLDHYHLNESTGLANPTSEAIAKWIYEQLEPQIPGLVAVRIDETCTSQCIY 438


>UniRef50_B7K1S3 Queuosine biosynthesis protein QueD n=6 Tax=Cyanobacteria
           RepID=B7K1S3_CYAP8
          Length = 136

 Score =  104 bits (260), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 55/119 (46%), Positives = 80/119 (67%), Gaps = 8/119 (6%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV----DPHTGWIIDFAELKAA 61
           +FK+F FEAAHRLPH     KC RLHGHS++ R+ + G+      P  G I+DF++++  
Sbjct: 11  IFKEFRFEAAHRLPHYDG--KCHRLHGHSWVGRIYVQGDRLVKDGPKQGMIMDFSDIQRY 68

Query: 62  FKPTYER-LDHHYLNDIPGLENPTSEVLAKWIWDQV-KPVVPLLSAVMVKETCTAGCIY 118
            +P  E  LDH+YLN+  GLENPT E +A+WI++++ K  +  L AV ++ETCT+G  Y
Sbjct: 69  LEPLLENFLDHYYLNETMGLENPTCEAVAQWIFEKLEKAGLQGLQAVEIQETCTSGVRY 127


>UniRef50_C6QGG4 Queuosine biosynthesis protein QueD n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QGG4_9RHIZ
          Length = 181

 Score =  102 bits (254), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 49/102 (48%), Positives = 67/102 (65%), Gaps = 1/102 (0%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           +TFEAAH LP V +GHKC RLHGH++ V + + G +D   G+++D+AEL    +P  + L
Sbjct: 73  YTFEAAHFLPKVHDGHKCRRLHGHNYRVDVSVAGGLD-ERGFVLDYAELDGIVQPVIDEL 131

Query: 70  DHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKET 111
           DH  LNDIPGLENPTSE+LA W+  ++         + V ET
Sbjct: 132 DHRCLNDIPGLENPTSEILALWLRSRIAAKAGTKPMIRVWET 173


>UniRef50_A1WW30 Putative uncharacterized protein n=1 Tax=Halorhodospira halophila
           SL1 RepID=A1WW30_HALHL
          Length = 258

 Score =  101 bits (251), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 54/114 (47%), Positives = 71/114 (62%), Gaps = 11/114 (9%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           ++ F FEAAHRLP+VPEGH CGR+HGH ++V LE  G  DP          L  A+ P  
Sbjct: 38  WRAFRFEAAHRLPYVPEGHPCGRMHGHGYLVVLEAAGG-DPEA--------LGEAWAPLG 88

Query: 67  ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           + LD   LND   L+NPTSE++A W+W+Q++P  P L  + V ET  +GC Y G
Sbjct: 89  QALDRACLNDF--LDNPTSELIAVWLWEQLRPRCPGLIRLHVHETEHSGCTYDG 140



 Score = 60.8 bits (146), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 31/78 (39%), Positives = 46/78 (58%), Gaps = 2/78 (2%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           T++K   FEAA  +    +     RLHGH + +R+ +T  +D   GW +D+ ++KAAF P
Sbjct: 144 TIWKAQRFEAATCVADADDTRA--RLHGHGYRLRVHVTAPLDRVLGWTLDYGDVKAAFAP 201

Query: 65  TYERLDHHYLNDIPGLEN 82
             E LDH  L+ I GLE+
Sbjct: 202 VREALDHQRLDTIAGLES 219


>UniRef50_A7HXX3 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Parvibaculum
           lavamentivorans DS-1 RepID=A7HXX3_PARL1
          Length = 122

 Score =  100 bits (249), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 50/116 (43%), Positives = 72/116 (62%), Gaps = 1/116 (0%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           ++K+F F+AAH LP+  EGH   R+HGHSF V + + G+    TG +  F +++      
Sbjct: 3   IYKEFLFDAAHFLPYAEEGHPNRRMHGHSFRVVVWLKGKPAAETGIVRHFEDVEREIMAV 62

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYRG 120
            E+LDHH LN+I GLE PT E +A WIWD +   +P ++ V V + +C  GCIY G
Sbjct: 63  REKLDHHLLNEIEGLEFPTLERIAAWIWDALATPLPEIARVEVHRASCREGCIYDG 118


>UniRef50_Q55798 6-carboxy-5,6,7,8-tetrahydropterin synthase n=7 Tax=Bacteria
           RepID=QUED_SYNY3
          Length = 129

 Score = 99.4 bits (246), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 57/119 (47%), Positives = 78/119 (65%), Gaps = 8/119 (6%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGE----VDPHTGWIIDFAELKAA 61
           ++K+F+FEAAH+LPH  EG KC RLHGHSF  R+ +  +        TG ++DF+ LKA 
Sbjct: 4   IYKEFSFEAAHQLPH-HEG-KCRRLHGHSFRGRVYVASDRLKTTGSETGMVMDFSVLKAH 61

Query: 62  FKPTYER-LDHHYLNDIPGLENPTSEVLAKWIWDQVKPV-VPLLSAVMVKETCTAGCIY 118
             P  +  LDH+YLND  GLE+PTSE +A WI+ +++   VP L +V V ETCT+   Y
Sbjct: 62  LDPLVKNHLDHYYLNDSLGLESPTSEAIAAWIFAKLEEAGVPGLHSVEVLETCTSAARY 120


>UniRef50_A3UD70 6-pyruvoyl tetrahydrobiopterin synthase, putative n=1
           Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UD70_9RHOB
          Length = 132

 Score = 92.4 bits (228), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 43/113 (38%), Positives = 68/113 (60%), Gaps = 1/113 (0%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           KDFTF+AAH   H    H   R+HGHSF   + +TG     +G + DF E++A      E
Sbjct: 18  KDFTFDAAHHFEHKDANHPFSRMHGHSFAGTVTLTGSRAAESGMVKDFWEIEAEINKIRE 77

Query: 68  RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKE-TCTAGCIYR 119
           +LDH  LND+ GLE+P+ E +A W++++++  +P L+AV ++  +C    + R
Sbjct: 78  QLDHRLLNDVEGLEHPSLEAIAYWVFERLEKTLPGLTAVEIRRPSCGEKAVVR 130


>UniRef50_B6CWI6 ToyB n=5 Tax=Bacteria RepID=B6CWI6_STRRM
          Length = 131

 Score = 91.7 bits (226), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 51/116 (43%), Positives = 73/116 (62%), Gaps = 4/116 (3%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT--GWIIDFAELKAAFKPT 65
           K+F F A+HRL H+ EGH C R+HGH+++V LE++   D  T  G++ D+ EL AAFK  
Sbjct: 17  KEFHFSASHRLDHLDEGHPCSRMHGHNYVVELELSAGDDALTKAGFVRDYGEL-AAFKQW 75

Query: 66  YE-RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            +  LDH +LND+    NP++E LA+WI ++ +   P L+AV V ET      YR 
Sbjct: 76  LDAELDHRHLNDVVDGLNPSAENLARWIHERWRTGFPELTAVRVSETDKTWAEYRA 131


>UniRef50_Q3SPB8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Alphaproteobacteria
           RepID=Q3SPB8_NITWN
          Length = 123

 Score = 87.4 bits (215), Expect = 1e-16,   Method: Compositional matrix adjust.
 Identities = 43/115 (37%), Positives = 60/115 (52%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           L K F FEAAH LP    G     +HGHSF   + + G  DP +G ++D   L+      
Sbjct: 4   LTKSFRFEAAHALPGTTLGAASMEIHGHSFRAEVSLRGTPDPASGMVLDLGLLERGMGEV 63

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
             +LDH  LND+ GL  PT E LA++IWD V+    +    + +++C   C Y G
Sbjct: 64  RNKLDHKLLNDVEGLGPPTLENLARFIWDHVQHAGAVTRVSVHRDSCGESCAYFG 118


>UniRef50_A2SD50 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=5
           Tax=Proteobacteria RepID=A2SD50_METPP
          Length = 129

 Score = 86.7 bits (213), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 42/118 (35%), Positives = 72/118 (61%), Gaps = 4/118 (3%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCG---RLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           L + F FE+AH L    E ++     R+HGH++   + + GE DP TG ++D A L++A 
Sbjct: 4   LSQSFYFESAHTLRRQVERNEADGSRRVHGHTYTAEVTVRGEADPATGMVVDLALLRSAI 63

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYR 119
               E+LDHH+L+++PGL  PT E L ++I +++   VP +++V V +++    C +R
Sbjct: 64  ATVREQLDHHFLDEVPGLGLPTLENLCRFIHERLLTTVPAIASVSVGRQSSGDRCTFR 121


>UniRef50_A4XG23 Putative uncharacterized protein n=4 Tax=Bacteria
           RepID=A4XG23_CALS8
          Length = 121

 Score = 86.3 bits (212), Expect = 3e-16,   Method: Compositional matrix adjust.
 Identities = 54/121 (44%), Positives = 71/121 (58%), Gaps = 10/121 (8%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KP 64
           L K F F+AAH L       KC RLHGH++ + + + G++D     +IDFA LK    K 
Sbjct: 3   LKKIFKFDAAHNLTKYH--GKCERLHGHTYKLVVTVKGKLDEQ-DMVIDFALLKDIVQKE 59

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIW----DQVKPVVPLLSAVMVKETCTAGCIYRG 120
             + LDH YLNDI  +ENPT+E +AKWIW    D++K     L  V V ET  +G +YRG
Sbjct: 60  VIDILDHAYLNDI--IENPTAENIAKWIWQRLYDKIKAQNSTLYEVEVWETEDSGAVYRG 117

Query: 121 E 121
           E
Sbjct: 118 E 118


>UniRef50_Q0BPQ0 Queuosine biosynthesis protein queD n=2 Tax=Proteobacteria
           RepID=Q0BPQ0_GRABC
          Length = 130

 Score = 83.6 bits (205), Expect = 2e-15,   Method: Compositional matrix adjust.
 Identities = 44/114 (38%), Positives = 63/114 (55%), Gaps = 1/114 (0%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           K FTFEAAH L    E     R+HGHS+ V + + G VDP +G ++D   L+       +
Sbjct: 16  KQFTFEAAHTLHREIETDSSLRIHGHSYRVEVVLRGGVDPDSGMLMDLGLLQRKMNAVRD 75

Query: 68  RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYRG 120
            LDH  L+++PGL   T E +A +IW  + P +P L+ V V ++T    C  RG
Sbjct: 76  ALDHRLLDEVPGLAPATMENIALFIWRHLAPDLPALAEVSVFRDTLGERCTCRG 129


>UniRef50_Q2IJB0 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Anaeromyxobacter
           RepID=Q2IJB0_ANADE
          Length = 129

 Score = 82.8 bits (203), Expect = 3e-15,   Method: Compositional matrix adjust.
 Identities = 46/113 (40%), Positives = 68/113 (60%), Gaps = 5/113 (4%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP-TYE 67
           +F F AAHRLP   EG  C R+HGH++   + + GEVDP TG I DF ++K         
Sbjct: 17  EFYFAAAHRLPRY-EG-PCFRMHGHNYRFFVALEGEVDPATGMIADFGDVKRIVAEHVLA 74

Query: 68  RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           R+DH  LND+  L+NPT+E +A+W+W+ ++P +  L  + + E   +   YRG
Sbjct: 75  RVDHRTLNDV--LDNPTAENIARWMWEVLEPHLAGLCEIRLYEIPDSCVTYRG 125


>UniRef50_Q2K3W9 6-pyruvoyl tetrahydropterin synthase protein n=19
           Tax=Alphaproteobacteria RepID=Q2K3W9_RHIEC
          Length = 119

 Score = 82.0 bits (201), Expect = 6e-15,   Method: Compositional matrix adjust.
 Identities = 43/118 (36%), Positives = 66/118 (55%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K+F   A+H+L H+P  H+C RLHGH+++V +E++ E     G++ D+ +L   
Sbjct: 1   MMYRITKEFHLSASHQLDHLPADHQCARLHGHNYVVVVELSAENLNDDGFVRDYHDLAPL 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
            +   E LDH +LN++ G    TSE LAK  +D  +   P  S+V V ET      YR
Sbjct: 61  KRYIDESLDHRHLNEVFGHSKVTSEFLAKHFYDWCRERFPETSSVRVSETPKTWAEYR 118


>UniRef50_B9K796 Queuosine biosynthesis protein QueD n=2 Tax=Bacteria
           RepID=B9K796_THENN
          Length = 131

 Score = 80.5 bits (197), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 50/126 (39%), Positives = 75/126 (59%), Gaps = 14/126 (11%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           +  L K F+FEAAH L  V    KC RLHGH++ + +++ G ++     ++DFAELK   
Sbjct: 11  NMVLVKKFSFEAAHNL--VKYHGKCERLHGHTYRLTVKVEGPLNEE-DMVMDFAELKKMV 67

Query: 63  KP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL------LSAVMVKETCTAG 115
           +    ++LDH YLN++   E PT+E +A WIW+Q+    PL      L  + + ET T+G
Sbjct: 68  EDRVIKKLDHSYLNEL--FEQPTTERVAIWIWEQLSG--PLRECGVRLVEIELWETETSG 123

Query: 116 CIYRGE 121
            +YRGE
Sbjct: 124 VVYRGE 129


>UniRef50_A8L9C2 Putative uncharacterized protein n=1 Tax=Frankia sp. EAN1pec
           RepID=A8L9C2_FRASN
          Length = 140

 Score = 80.1 bits (196), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 47/116 (40%), Positives = 65/116 (56%), Gaps = 6/116 (5%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           K FTF+AAH LP +P GHKC R+HGH++ V   +        G++ DF +L  A +   E
Sbjct: 20  KRFTFDAAHHLPSLPAGHKCSRVHGHTYTVEFVLAASELAGPGFVTDFGDLAVAGRYLAE 79

Query: 68  RLDHHYLNDIPGLENPTSEV----LAKWIWDQVKPVV-PLLSAVMVKETCTAGCIY 118
             DH  LN++  +E PTSE     LA+W   +V+P V   L AV V ET ++   Y
Sbjct: 80  SFDHRDLNEVLDVE-PTSEALAQHLARWFLAEVEPGVHGRLVAVRVSETPSSWAEY 134


>UniRef50_D0B3L9 6-pyruvoyl tetrahydrobiopterin synthase n=47 Tax=Bacteria
           RepID=D0B3L9_BRUME
          Length = 121

 Score = 80.1 bits (196), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 45/113 (39%), Positives = 67/113 (59%), Gaps = 2/113 (1%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKAAFKPTY 66
           K+F F A+H+L  +P  H+C RLHGH+++V +E++  ++D H G++ D+ EL A      
Sbjct: 6   KEFHFSASHQLTGLPADHQCARLHGHNYIVEVELSAPDLDTH-GFVRDYHELAALKHYID 64

Query: 67  ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
           +  DH +LND+ G E  T+E LAK  +D      P +SAV V ET      YR
Sbjct: 65  DTFDHRHLNDVLGHEQTTAERLAKHFFDWCHARWPEISAVRVSETPKTWAEYR 117


>UniRef50_D0Y1P4 6-pyruvoyl tetrahydropterin synthase n=3 Tax=cellular organisms
           RepID=D0Y1P4_9CAUL
          Length = 121

 Score = 79.7 bits (195), Expect = 2e-14,   Method: Compositional matrix adjust.
 Identities = 44/107 (41%), Positives = 58/107 (54%), Gaps = 2/107 (1%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F+AAH +   P  H+  +LHGHSF V   + GE+ P  GW+ D   L AA K     LDH
Sbjct: 13  FDAAHYIEQGPADHRYRKLHGHSFKVEASVKGEMAP-AGWVADLDSLDAALKAVAAELDH 71

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAV-MVKETCTAGCI 117
             LND PGLE PT E L  +  +++K   P LS V + + T    C+
Sbjct: 72  GLLNDKPGLETPTLERLCLYFAERLKVQFPGLSRVELSRPTIGERCV 118


>UniRef50_Q0RM63 6-pyruvoyl tetrahydrobiopterin synthase n=11 Tax=Bacteria
           RepID=Q0RM63_FRAAA
          Length = 130

 Score = 79.0 bits (193), Expect = 4e-14,   Method: Compositional matrix adjust.
 Identities = 46/123 (37%), Positives = 67/123 (54%), Gaps = 5/123 (4%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M +  + K F F A+HRL  +P  HKC RLHGH++ VR+++ GE     G+++D+ EL  
Sbjct: 3   MPAFEISKTFEFSASHRLSGLPADHKCARLHGHNYTVRVQLRGETLDPVGFLLDYGELSP 62

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLS----AVMVKETCTAGC 116
                   LDH +LN      NPT+E+LA+ +   V+ +VP+      AV V ET     
Sbjct: 63  VRDWIDAALDHQHLNACLDF-NPTAELLAQHLAGTVRQLVPIPDGVRVAVGVSETPRTWA 121

Query: 117 IYR 119
            YR
Sbjct: 122 FYR 124


>UniRef50_B0SX52 Queuosine biosynthesis protein QueD n=1 Tax=Caulobacter sp. K31
           RepID=B0SX52_CAUSK
          Length = 121

 Score = 79.0 bits (193), Expect = 5e-14,   Method: Compositional matrix adjust.
 Identities = 43/111 (38%), Positives = 58/111 (52%), Gaps = 6/111 (5%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           K  TF+AAH +   P  H+  +LHGHSF V   + G +    GW+ D   L  A K    
Sbjct: 9   KAATFDAAHYIEQGPPDHRYRKLHGHSFKVEASVRGALQ-EAGWVADLDSLDGALKAVAA 67

Query: 68  RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK-----ETCT 113
            LDH  LND PGLE+PT E L  +  +++ P  P LS V++      E+C 
Sbjct: 68  ELDHGLLNDRPGLESPTLERLCLYFAERLTPRFPGLSRVVISRPTIGESCA 118


>UniRef50_B4RHW0 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Caulobacteraceae
           RepID=B4RHW0_PHEZH
          Length = 125

 Score = 77.8 bits (190), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 45/111 (40%), Positives = 58/111 (52%), Gaps = 3/111 (2%)

Query: 2   MSTTLF---KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAEL 58
           MS  +F   K  TF+AAH L   P       LHGHSF V   + G+     GW+ D A+L
Sbjct: 1   MSQPVFEITKAATFDAAHYLAEGPAHRPYTNLHGHSFKVEATVRGQPQEPVGWVADLADL 60

Query: 59  KAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
             A K     LDH  LN+ PGLE PT E L  +  ++++P  P LS V+V 
Sbjct: 61  DEALKAVAGELDHGLLNEKPGLERPTLEHLCLYFAERLRPRFPGLSRVVVS 111


>UniRef50_D0J5V8 6-pyruvoyl tetrahydropterin synthase and n=7 Tax=Comamonadaceae
           RepID=D0J5V8_COMTE
          Length = 121

 Score = 77.8 bits (190), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 38/117 (32%), Positives = 65/117 (55%), Gaps = 1/117 (0%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M  T+ + F F+AAH L    E     R+HGH++   + + G  +P  G +ID   L+A 
Sbjct: 1   MQFTVHQRFFFDAAHTLERAIETESSRRIHGHTYWAEVSVRGPRNPDNGMVIDLGHLRAR 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCI 117
            +   ++LDHH+L+++PGL  PT E L  +I + +  + P  S + V +++   GC+
Sbjct: 61  LELLRDQLDHHFLDEVPGLGKPTLENLCLFIANALADLEPAPSRIRVWRDSIGDGCV 117


>UniRef50_C0GP47 Queuosine biosynthesis protein QueD n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GP47_9DELT
          Length = 128

 Score = 77.4 bits (189), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 45/114 (39%), Positives = 67/114 (58%), Gaps = 9/114 (7%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKAAFKPTYERLD 70
           F ++H+L +   G KC  LHGH+F V++++ G EVDP TG ++DF ELK       E LD
Sbjct: 14  FSSSHQLRNY--GGKCESLHGHNFQVQVQVCGKEVDPDTGMLMDFKELKNTLLAVLEELD 71

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIY 118
           H +LND+P  +  NP+SE LA +++  +K  +      L  VMV E  ++   Y
Sbjct: 72  HKHLNDLPHFKETNPSSENLACFVYQGLKKSLGNRGVYLDWVMVAEKDSSRAYY 125


>UniRef50_A3VUJ4 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Parvularcula
           bermudensis HTCC2503 RepID=A3VUJ4_9PROT
          Length = 136

 Score = 77.4 bits (189), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 46/102 (45%), Positives = 58/102 (56%), Gaps = 3/102 (2%)

Query: 10  FTFEAAHRLPHV-PE--GHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           F FEAAH L  + PE   H    +HGHSF V + +        GWI+DFAELKAA +   
Sbjct: 22  FFFEAAHELGEMKPEDSAHLYAEIHGHSFEVTVTLAAATIEPEGWIMDFAELKAACETVR 81

Query: 67  ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV 108
             LDH  LN I GL  PT E LA +I +++ P +P LS V +
Sbjct: 82  GLLDHRLLNRIEGLSRPTLERLADFIIERLSPDLPALSEVEI 123


>UniRef50_D2L9S0 Putative uncharacterized protein n=1 Tax=Desulfovibrio sp.
          FW1012B RepID=D2L9S0_9DELT
          Length = 124

 Score = 76.3 bits (186), Expect = 3e-13,   Method: Compositional matrix adjust.
 Identities = 39/86 (45%), Positives = 52/86 (60%), Gaps = 3/86 (3%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          F AAHRLP  P    C  +HGH+F V + +T       G + DF +++AA    + RLDH
Sbjct: 13 FSAAHRLPDHP--GPCAFMHGHNFEVAVALTATALVR-GMVADFLDVRAALDAAFARLDH 69

Query: 72 HYLNDIPGLENPTSEVLAKWIWDQVK 97
            LNDIP L  PT+EVLA WI+ Q++
Sbjct: 70 ACLNDIPELSPPTAEVLAAWIFGQLR 95


>UniRef50_A6GQ16 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Limnobacter sp. MED105 RepID=A6GQ16_9BURK
          Length = 116

 Score = 73.9 bits (180), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 43/112 (38%), Positives = 64/112 (57%), Gaps = 12/112 (10%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT-GWIIDFAELKAAFKP 64
           +FK FTF+ AH+LP  P       LHGHS+   +   G   P T G+++  + L      
Sbjct: 3   VFKQFTFDVAHQLPDWP------GLHGHSYTAEVWFEG---PATDGYVVPESLLTQHVGA 53

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGC 116
            ++RLDH YLN+   +E PTSE +A+WIWDQ++PV PL+   + + +   G 
Sbjct: 54  VHKRLDHSYLNEF--IELPTSENIARWIWDQLRPVGPLIKVKVFRGSIGFGV 103


>UniRef50_B5YCT3 6-pyruvoyl-tetrahydropterin synthase n=24 Tax=Bacteria
           RepID=B5YCT3_DICT6
          Length = 125

 Score = 73.9 bits (180), Expect = 1e-12,   Method: Compositional matrix adjust.
 Identities = 47/121 (38%), Positives = 68/121 (56%), Gaps = 10/121 (8%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK-P 64
           + + F F+AAH L       KC RLHGH++ + + + G  D   G IIDF ELK   K  
Sbjct: 3   VIRKFKFDAAHNLESYK--GKCERLHGHTYRLVVIVEGIPDSE-GMIIDFVELKDIVKRE 59

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCIYRG 120
             + LDH Y+N+I  ++ PT+E +A WIW +++  +      L  + V ET  +G IYRG
Sbjct: 60  VIDILDHSYINEI--IKQPTAENIAIWIWQRLEEKLKRGNCHLYEIQVWETEDSGVIYRG 117

Query: 121 E 121
           E
Sbjct: 118 E 118


>UniRef50_A9AWJ6 Putative uncharacterized protein n=1 Tax=Herpetosiphon aurantiacus
           ATCC 23779 RepID=A9AWJ6_HERA2
          Length = 133

 Score = 73.2 bits (178), Expect = 2e-12,   Method: Compositional matrix adjust.
 Identities = 40/112 (35%), Positives = 63/112 (56%), Gaps = 9/112 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-----HTGWIIDFA 56
           M   L K F FEAAH+LP+     KC RLHGHS+++ + + G + P       G +ID  
Sbjct: 1   MYAILTKQFRFEAAHQLPN--HRGKCARLHGHSYLLEVSVRGLIQPTRGQSDDGMVIDLE 58

Query: 57  ELKAAFKP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVM 107
           ++K         R+DH+ LND   + + T+E +A W+WDQ++   P  +A++
Sbjct: 59  QIKQLVNEIIIARVDHYNLNDFLSVPS-TAENIAHWMWDQLEQQAPEFAALL 109


>UniRef50_C4XPJ5 6-pyruvoyl tetrahydropterin synthase family protein n=1
          Tax=Desulfovibrio magneticus RS-1 RepID=C4XPJ5_DESMR
          Length = 123

 Score = 70.9 bits (172), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 36/86 (41%), Positives = 50/86 (58%), Gaps = 3/86 (3%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          F AAHRLP  P    C  +HGH+F V  EI  +     G + DF +++ A    +  LDH
Sbjct: 13 FSAAHRLPGHPG--PCAAMHGHNFQVTAEICAD-SLINGMVADFLDVRTAMDAIFADLDH 69

Query: 72 HYLNDIPGLENPTSEVLAKWIWDQVK 97
            LND+P L+ PT+EVLA +I  ++K
Sbjct: 70 ACLNDVPALDPPTAEVLAGYILSRLK 95


>UniRef50_C9LTT9 Queuosine biosynthesis protein QueD n=3 Tax=Bacteria
          RepID=C9LTT9_9FIRM
          Length = 125

 Score = 70.9 bits (172), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 36/88 (40%), Positives = 54/88 (61%), Gaps = 4/88 (4%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          FEAAHR+ + P   KC RLHGH++ V L+I+G      G +IDF   KA  +     LDH
Sbjct: 10 FEAAHRIVNYP--GKCDRLHGHNWKVELKISGSRLDELGMLIDFKAAKAMLQEVVNSLDH 67

Query: 72 HYLNDIPGLE--NPTSEVLAKWIWDQVK 97
           +LN++      NPT+E +A++I+ ++K
Sbjct: 68 RFLNELEPFSEINPTAENIARYIYQELK 95


>UniRef50_C9RBW1 Putative uncharacterized protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RBW1_AMMDK
          Length = 124

 Score = 70.9 bits (172), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 45/117 (38%), Positives = 64/117 (54%), Gaps = 12/117 (10%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           +F AAHRLP+ P    C RLHGH++ V + + GE     G ++DF  LK   +    +LD
Sbjct: 9   SFSAAHRLPNHPS--PCSRLHGHNWEVTVTVIGEELGPDGMLLDFTVLKQILQEVLAKLD 66

Query: 71  HHYLNDIPGLEN---PTSEVLAKWIWDQVK------PVVPLLSAVMVKETCTAGCIY 118
           H YLN+IP       PT+E LA++I+ +V       P V  L  V V E+ +A  +Y
Sbjct: 67  HQYLNEIPPFGKELPPTAENLARYIYHEVATRLAPYPAV-TLQEVKVGESPSAWVVY 122


>UniRef50_O31676 6-carboxy-5,6,7,8-tetrahydropterin synthase n=85 Tax=Bacillales
           RepID=QUED_BACSU
          Length = 146

 Score = 70.1 bits (170), Expect = 2e-11,   Method: Compositional matrix adjust.
 Identities = 44/129 (34%), Positives = 65/129 (50%), Gaps = 16/129 (12%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  L KD    AAH +P    G  C R+HGH++ V + + G+    +G++++F+ LK   
Sbjct: 14  SFELNKDMHISAAHFIPRESAG-ACSRVHGHTYTVNITVAGDELDDSGFLVNFSVLKKLV 72

Query: 63  KPTYERLDHHYLNDIPGLEN------PTSEVLAKWIWDQVKPVV------PLLSAVMVKE 110
              Y   DH  LND            PT+EV+AK I+D V+  +      P    V V+E
Sbjct: 73  HGNY---DHTLLNDHEDFSQDDRYSLPTTEVVAKTIYDNVQAYLDTLENKPTCVQVFVRE 129

Query: 111 TCTAGCIYR 119
           T T+ C+YR
Sbjct: 130 TPTSYCVYR 138


>UniRef50_C1TQH0 PreQ(0) biosynthesis protein QueD n=2 Tax=Bacteria
           RepID=C1TQH0_9BACT
          Length = 139

 Score = 68.9 bits (167), Expect = 4e-11,   Method: Compositional matrix adjust.
 Identities = 43/117 (36%), Positives = 63/117 (53%), Gaps = 10/117 (8%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KP 64
           L K+FTF+AAHRL       KC  LHGH++ + + + G  D     + DF ELK    + 
Sbjct: 21  LRKEFTFDAAHRLERYR--GKCEALHGHTYRLAVTLNGRSDDE-DMVFDFTELKRIVSEK 77

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCI 117
               LDH YLND+  ++ PT+E +A W+W ++   V      L +V + ET T+  I
Sbjct: 78  ILTELDHAYLNDV--MDQPTAENIALWVWRKLDESVKRPNCELHSVQIWETATSSVI 132


>UniRef50_B5Y6S0 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Bacteria
           RepID=B5Y6S0_COPPD
          Length = 127

 Score = 68.9 bits (167), Expect = 5e-11,   Method: Compositional matrix adjust.
 Identities = 46/121 (38%), Positives = 71/121 (58%), Gaps = 14/121 (11%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH---TGWIIDFAEL 58
           M+  + K FTF+AAH L +     KC  LHGH++  RLE+T    P+    G ++DF +L
Sbjct: 1   MNVCVTKAFTFDAAHNLTNYK--GKCEALHGHTY--RLEVTVCGTPNELENGLLMDFGDL 56

Query: 59  KAAF-KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCT 113
           K    K    +LDH YLND    E P++E++A W+++ +KP V     +L++V + ET T
Sbjct: 57  KDLVNKEVLSKLDHSYLND--HFEQPSTELVAMWVFETLKPHVEKLGLVLTSVKLFETAT 114

Query: 114 A 114
           +
Sbjct: 115 S 115


>UniRef50_C9KKI2 Queuosine biosynthesis protein QueD n=2 Tax=Veillonellaceae
           RepID=C9KKI2_9FIRM
          Length = 136

 Score = 68.2 bits (165), Expect = 7e-11,   Method: Compositional matrix adjust.
 Identities = 43/122 (35%), Positives = 64/122 (52%), Gaps = 10/122 (8%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           TL  +  FEAAHR+ + P   KC RLHGH++ V   + G      G ++DF  +K A K 
Sbjct: 14  TLKVEGAFEAAHRVVNYP--GKCDRLHGHNWKVEAVVRGTELDELGMLVDFKAIKNALKG 71

Query: 65  TYERLDHHYLNDIPGLE---NPTSEVLAKWIWDQVKPVVPL-----LSAVMVKETCTAGC 116
             +R DH +LN++       NPT+E LA+ I++++           L A+ V ET T+  
Sbjct: 72  VLDRFDHRFLNELEPFAAGINPTAENLARIIFEELAGNDAFVRDSELFAITVYETPTSSV 131

Query: 117 IY 118
            Y
Sbjct: 132 TY 133


>UniRef50_Q1IHK8 Putative uncharacterized protein n=3 Tax=Acidobacteria
          RepID=Q1IHK8_ACIBL
          Length = 125

 Score = 67.8 bits (164), Expect = 9e-11,   Method: Compositional matrix adjust.
 Identities = 33/87 (37%), Positives = 50/87 (57%), Gaps = 4/87 (4%)

Query: 11 TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
          TF A H L +     KC   HGH++ VR+ + G    H G ++DF +LK   KP  + LD
Sbjct: 9  TFAAGHYLRNYK--GKCENPHGHNYKVRVTLQGRELDHAGLLLDFKDLKVVMKPVVDYLD 66

Query: 71 HHYLNDIPGLE--NPTSEVLAKWIWDQ 95
          H  +NDIP     NP++E +A++ +D+
Sbjct: 67 HQMMNDIPPFNEVNPSAENIARYFYDE 93


>UniRef50_B8J0W0 Queuosine biosynthesis protein QueD n=8 Tax=Desulfovibrionales
           RepID=B8J0W0_DESDA
          Length = 135

 Score = 67.8 bits (164), Expect = 1e-10,   Method: Compositional matrix adjust.
 Identities = 39/92 (42%), Positives = 54/92 (58%), Gaps = 5/92 (5%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKAAFKPTYERLD 70
           F A H L H  EG KC R+HGH+F V L + G  + P T  ++DF  LK A K   + LD
Sbjct: 14  FSAGHALRHY-EG-KCERMHGHNFAVELTVEGNRLAPQTEMLLDFKILKKALKAVLDALD 71

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV 100
           H  LN+ P  +  NP+SE LA+ IW  ++ ++
Sbjct: 72  HRLLNETPPFDRINPSSENLARHIWQGMEALL 103


>UniRef50_Q3ADI6 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
          Tax=Carboxydothermus hydrogenoformans Z-2901
          RepID=Q3ADI6_CARHZ
          Length = 120

 Score = 67.0 bits (162), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 35/88 (39%), Positives = 51/88 (57%), Gaps = 3/88 (3%)

Query: 11 TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
          TF+AAH L       KC  LHGH++ V  E+ G+     G +IDF  +K   K    RLD
Sbjct: 9  TFDAAHFLKDYD--GKCANLHGHTWRVEAEVEGQTTNDLGLLIDFGMIKDYLKDITSRLD 66

Query: 71 HHYLNDIPGLENPTSEVLAKWIWDQVKP 98
          H  LND+  + NPT+E +A++I+ ++K 
Sbjct: 67 HKLLNDVLQV-NPTAENIARYIFKELKA 93


>UniRef50_B0VJG6 6-pyruvoyl tetrahydrobiopterin synthase family protein n=1
           Tax=Candidatus Cloacamonas acidaminovorans
           RepID=B0VJG6_9BACT
          Length = 126

 Score = 67.0 bits (162), Expect = 2e-10,   Method: Compositional matrix adjust.
 Identities = 48/119 (40%), Positives = 64/119 (53%), Gaps = 12/119 (10%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           TF AAH L    EG  C +LHGH++ VR+ +  +     G  +DF  LK         LD
Sbjct: 9   TFSAAHLLRGY-EG-ACSKLHGHNWKVRVCVKTKEQDEIGMAMDFGVLKTILSNILNNLD 66

Query: 71  HHYLNDI-PGLE-NPTSEVLAKWIWD------QVKPVVPLLSAVMVKETCTAGCIYRGE 121
           H YLN+I P  E NPTSE LAK+I++      Q KPV   +S V V E+  +  IY+ +
Sbjct: 67  HSYLNEIVPFTERNPTSENLAKYIYECMEKELQDKPVA--ISEVEVYESEKSSVIYKND 123


>UniRef50_Q3B4V1 6-pyruvoyltetrahydropterin synthase n=11 Tax=Chlorobiaceae
           RepID=Q3B4V1_PELLD
          Length = 162

 Score = 66.2 bits (160), Expect = 3e-10,   Method: Compositional matrix adjust.
 Identities = 51/135 (37%), Positives = 64/135 (47%), Gaps = 21/135 (15%)

Query: 8   KDFTFEAAHRL--PHVPEGH------KCGRLHGHSFMVRLEIT--GEVDPHTGWIIDFAE 57
           +   F AAHRL  P   E        KC   +GH    +LEIT  G VDP TG++ D  E
Sbjct: 28  RTIEFNAAHRLFNPKFSEEMNTRVYGKCANKYGHGHNYQLEITLGGTVDPETGYLFDLKE 87

Query: 58  LKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL-------LSAV 106
           LK    +    R DH +LN D+P LE   PT+E LA  IWD ++  +         L AV
Sbjct: 88  LKKILEEEVTARFDHRHLNHDVPELEGLVPTTETLAVLIWDILEERIAAIDNREISLQAV 147

Query: 107 MVKETCTAGCIYRGE 121
            + ET      Y GE
Sbjct: 148 KLHETGKNSVSYLGE 162


>UniRef50_B5W8I5 Putative uncharacterized protein n=3 Tax=Cyanobacteria
           RepID=B5W8I5_SPIMA
          Length = 130

 Score = 65.9 bits (159), Expect = 4e-10,   Method: Compositional matrix adjust.
 Identities = 50/132 (37%), Positives = 69/132 (52%), Gaps = 14/132 (10%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT------GEVDPHTGWIID 54
           M    L  +FTF++AH +        CGRLHGH++ VR+E T       E  PH   + D
Sbjct: 1   MSKWKLTTEFTFDSAHYIKDY--NGPCGRLHGHTYKVRVEATSNQLHGSEFCPHPVMVAD 58

Query: 55  FAELKAAFKPTYE-RLDHHYLNDI--PGLENPTSEVLAKWIWDQVKPVVP--LLSAVMVK 109
           F  L+ A K   +  LDH  LN+I  P  E  T+E++AK+I+D+ K  VP  +   VMV 
Sbjct: 59  FRSLRWAKKDVSKGGLDHGLLNEILPPNYET-TAEMIAKFIYDETKKRVPEGVQLKVMVS 117

Query: 110 ETCTAGCIYRGE 121
           ET  +   Y  E
Sbjct: 118 ETANSWVEYEDE 129


>UniRef50_D1B660 Putative uncharacterized protein n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B660_THEAS
          Length = 121

 Score = 65.5 bits (158), Expect = 6e-10,   Method: Compositional matrix adjust.
 Identities = 45/116 (38%), Positives = 65/116 (56%), Gaps = 12/116 (10%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP- 64
           L + F+F AAH LP      +C  LHGH++   + + G  DP  G I+DF ELK   +  
Sbjct: 3   LKRRFSFSAAHWLPRY--KGRCEALHGHTYSFVITLEGSPDPE-GMIMDFTELKGLVEEM 59

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIW----DQVKPVVPLLSAVMVKET--CTA 114
              RLDH  LND+  LE PT+E L++WI+    D+++     L +V V E+  C+A
Sbjct: 60  VLSRLDHSCLNDL--LEQPTAEALSRWIFEALADRLEAPNRRLESVEVFESPDCSA 113


>UniRef50_B5YJJ7 6-pyruvoyl-tetrahydropterin synthase n=4 Tax=Bacteria
           RepID=B5YJJ7_THEYD
          Length = 122

 Score = 65.1 bits (157), Expect = 6e-10,   Method: Compositional matrix adjust.
 Identities = 39/113 (34%), Positives = 58/113 (51%), Gaps = 8/113 (7%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F+AAH+L       KC  +HGH++ V +E+  E     G  +DF ELK        +LDH
Sbjct: 10  FDAAHQLKGYK--GKCENIHGHNWKVEVEVISEKLNEIGIALDFKELKKNVDEVVSQLDH 67

Query: 72  HYLNDIPGLE--NPTSEVLAKWIW----DQVKPVVPLLSAVMVKETCTAGCIY 118
            ++N IP     NP+SE +A+WI+    D+    +  L +V V E+  A   Y
Sbjct: 68  TFINQIPPFTQLNPSSENIARWIYMSLKDKFNTTLVRLYSVTVWESDYASATY 120


>UniRef50_C8VWH9 Putative uncharacterized protein n=1 Tax=Desulfotomaculum
           acetoxidans DSM 771 RepID=C8VWH9_DESAS
          Length = 125

 Score = 64.7 bits (156), Expect = 8e-10,   Method: Compositional matrix adjust.
 Identities = 39/114 (34%), Positives = 62/114 (54%), Gaps = 9/114 (7%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F++AH L   P   KC  +HGH++ + + + GE    TG +IDF+ELK   K   E  DH
Sbjct: 13  FDSAHYLREYP--GKCKNVHGHTWYIEVVLQGENLDSTGILIDFSELKGLIKNIIEPFDH 70

Query: 72  HYLND-IP-GLENPTSEVLAKWIWDQVKPV-----VPLLSAVMVKETCTAGCIY 118
             LN+ +P  ++NPTSE LA++ + ++K       V L+   + +   TA   +
Sbjct: 71  QLLNEQVPFEVDNPTSENLARYFYHEIKKKLSDKPVKLVRVTVSESRATAAAYF 124


>UniRef50_B9ZMJ4 Queuosine biosynthesis protein QueD n=1 Tax=Thioalkalivibrio sp.
          K90mix RepID=B9ZMJ4_9GAMM
          Length = 127

 Score = 64.7 bits (156), Expect = 9e-10,   Method: Compositional matrix adjust.
 Identities = 32/88 (36%), Positives = 49/88 (55%), Gaps = 4/88 (4%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          F +AH L   P   +C  +HGH++ V  E+  E     G  +DF  +K A +    +LDH
Sbjct: 13 FASAHTLRDYP--GQCANMHGHNWKVEAEVQAETLDDAGMAVDFKVVKTAAREIAGQLDH 70

Query: 72 HYLNDIPGLE--NPTSEVLAKWIWDQVK 97
           YLND+P  +  NPT+E +A+W + Q+ 
Sbjct: 71 RYLNDVPPFDTVNPTAENIAQWFFRQMS 98


>UniRef50_Q63E30 6-pyruvoyl tetrahydrobiopterin synthase n=100 Tax=Bacilli
           RepID=Q63E30_BACCZ
          Length = 163

 Score = 64.3 bits (155), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 39/90 (43%), Positives = 55/90 (61%), Gaps = 4/90 (4%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           K+FTF+AAH L H  EG KC  LHGH++ V   I+G V+   G  IDF ++K  +K   E
Sbjct: 36  KEFTFDAAHHL-HCYEG-KCKNLHGHTYKVVFGISGYVNE-IGLAIDFGDIKEIWKNEIE 92

Query: 68  -RLDHHYLNDIPGLENPTSEVLAKWIWDQV 96
             LDH YLN+     N T+E +  WI++++
Sbjct: 93  IYLDHRYLNETLPAMNTTAENMVVWIYEKM 122


>UniRef50_C4V0R8 Possible 6-pyruvoyltetrahydropterin synthase n=1 Tax=Selenomonas
          flueggei ATCC 43531 RepID=C4V0R8_9FIRM
          Length = 126

 Score = 63.9 bits (154), Expect = 1e-09,   Method: Compositional matrix adjust.
 Identities = 38/95 (40%), Positives = 53/95 (55%), Gaps = 5/95 (5%)

Query: 5  TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
          TL  +  FEAAHR+   P   KC RLHGH+++V     G      G +IDF   KAA   
Sbjct: 3  TLRVEGAFEAAHRVVGYP--GKCDRLHGHNWVVEAVFRGTELDGLGMLIDFKTAKAALMA 60

Query: 65 TYERLDHHYLNDIP---GLENPTSEVLAKWIWDQV 96
            +  DH Y+N++P   G  NPT+E LA  I++++
Sbjct: 61 VLDAFDHRYINELPPFDGEVNPTAENLACIIYERL 95


>UniRef50_C7HJ58 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Clostridia
           RepID=C7HJ58_CLOTM
          Length = 127

 Score = 63.9 bits (154), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 33/97 (34%), Positives = 59/97 (60%), Gaps = 5/97 (5%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK- 63
           ++ K FTF++AH L  +    KC  +HGH++ + + + G  D + G ++DF +L+A  + 
Sbjct: 7   SITKLFTFDSAHHL--IDYNGKCRNIHGHTYKLEITLKGLPDEN-GLVMDFHDLEAIIEN 63

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV 100
              E++DH YLND+    NPT E++  W+W+++   V
Sbjct: 64  EVLEKVDHKYLNDVFDF-NPTCEMIGLWLWEEISKQV 99


>UniRef50_Q2IKV5 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Anaeromyxobacter
           RepID=Q2IKV5_ANADE
          Length = 138

 Score = 63.5 bits (153), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 11/123 (8%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           KDF F AAH++     G KC RLHGH++ VR+          G +IDFA+L+        
Sbjct: 18  KDFVFSAAHQIRF--HGGKCERLHGHNWRVRVHARASTLNRIGMVIDFADLQKLVAEVGS 75

Query: 68  RLDHHYLNDIP--GLENPTSEVLAKWIWDQVKPVVPLL-------SAVMVKETCTAGCIY 118
           R DH  +N++     EN T+E++A++ + ++   +  L       + V V E   +  IY
Sbjct: 76  RFDHQNVNEVAPFDQENTTAELIARFFYREMSRRLAELEGGRVTVARVDVWENEGSLAIY 135

Query: 119 RGE 121
           R E
Sbjct: 136 REE 138


>UniRef50_Q31FT9 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Gammaproteobacteria
           RepID=Q31FT9_THICR
          Length = 125

 Score = 63.5 bits (153), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 32/98 (32%), Positives = 55/98 (56%), Gaps = 4/98 (4%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F +AH L   P    C +LHGH++ + +++ G+     G ++DF E+K   K     LDH
Sbjct: 13  FASAHSLRGYPGD--CAKLHGHNWKIEVQVVGDKLNDIGMLVDFKEIKRHAKEVISELDH 70

Query: 72  HYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLLSAVM 107
            +LND P    +NPT+E +A++I+ Q++  +   +  M
Sbjct: 71  TFLNDHPHFKEKNPTAENIAEYIYKQIQQRIQSSTVKM 108


>UniRef50_C0QLV0 PtpS n=8 Tax=cellular organisms RepID=C0QLV0_DESAH
          Length = 127

 Score = 63.2 bits (152), Expect = 2e-09,   Method: Compositional matrix adjust.
 Identities = 33/89 (37%), Positives = 52/89 (58%), Gaps = 4/89 (4%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          F AAH+L  V  G KC  LHGH++ V + + GE     G ++DF  +K   +   + LDH
Sbjct: 10 FAAAHKLAMV--GEKCENLHGHNWDVEVYVAGEQLNEAGVLVDFGVIKGFVRKIMKELDH 67

Query: 72 HYLNDIPGLEN--PTSEVLAKWIWDQVKP 98
           YLN++    +  P+SE +A +I +++KP
Sbjct: 68 KYLNELDAFADVQPSSEQIAIYIANRLKP 96


>UniRef50_A1SFN0 Putative uncharacterized protein n=1 Tax=Nocardioides sp. JS614
          RepID=A1SFN0_NOCSJ
          Length = 118

 Score = 62.8 bits (151), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 38/92 (41%), Positives = 56/92 (60%), Gaps = 9/92 (9%)

Query: 2  MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
          M  ++ + + FEAAH LP  P   KC R+HGHS+++ + +TGE+D   G ++DFAE+ A 
Sbjct: 1  MRISIVRRYRFEAAHTLPWHPG--KCSRIHGHSYVLEVHVTGELDDR-GVVMDFAEVDAI 57

Query: 62 FKPTY----ERLDHHYLNDIPGLENPTSEVLA 89
                     LDH  LN +  LENPT+E++A
Sbjct: 58 VDQHVLEGPAGLDHVDLNAL--LENPTAELVA 87


>UniRef50_B1ZTR4 Putative uncharacterized protein n=3 Tax=Bacteria
           RepID=B1ZTR4_OPITP
          Length = 161

 Score = 62.4 bits (150), Expect = 4e-09,   Method: Compositional matrix adjust.
 Identities = 43/116 (37%), Positives = 61/116 (52%), Gaps = 16/116 (13%)

Query: 12  FEAAHRL--PHVPEGHKCGRL--------HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL  P   +     +         HGH++++ + + GE DP TG+I+D +ELK  
Sbjct: 30  FNAAHRLYNPTKSQAWNTNQYGLCTSPNWHGHNYVLEVTVRGEPDPETGYIVDLSELKRV 89

Query: 62  FKPT-YERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMVKET 111
              T  +R DH  LN D+  L N  PT+E L    WDQ++P +P   L  V + ET
Sbjct: 90  LHETVVDRCDHRNLNDDVDFLRNVIPTTENLVIAFWDQIEPALPAGKLHCVRLYET 145


>UniRef50_Q1ZXI0 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Eukaryota
           RepID=PTPS_DICDI
          Length = 135

 Score = 61.6 bits (148), Expect = 7e-09,   Method: Compositional matrix adjust.
 Identities = 42/123 (34%), Positives = 63/123 (51%), Gaps = 13/123 (10%)

Query: 12  FEAAHRL----PHVPEGHK----CGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
           F ++HRL      + E  K    C   HGH++++ + I G V    G  ++  ELK   K
Sbjct: 13  FSSSHRLYSDKLSLEENKKIYGKCINSHGHNYVLEVSIKGAVKEDIGMFMNITELKEILK 72

Query: 64  -PTYERLDHHYL-NDIPGLEN--PTSEVLAKWIWDQVKPVVP-LLSAVMVKETCTAGCIY 118
               ++LDH  L ND+P L+    T+E L+ +IWDQ+ P +   L  V + ET     +Y
Sbjct: 73  EKVMDKLDHKNLENDVPELKGIVTTTENLSIFIWDQLFPSLKDFLYEVKILETENNFVVY 132

Query: 119 RGE 121
           RGE
Sbjct: 133 RGE 135


>UniRef50_Q03393 6-pyruvoyl tetrahydrobiopterin synthase n=19 Tax=Bilateria
           RepID=PTPS_HUMAN
          Length = 145

 Score = 61.6 bits (148), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 42/130 (32%), Positives = 70/130 (53%), Gaps = 16/130 (12%)

Query: 8   KDFTFEAAHRL--------PHVPEGHKCGR--LHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           +  +F A+HRL         ++    KC     HGH++ V + + GE+DP TG +++ A+
Sbjct: 16  RRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNLAD 75

Query: 58  LKAAFKPTYER-LDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMVKET 111
           LK   +    + LDH  L+ D+P   +   T+E +A +IWD ++ V+P  +L  V V ET
Sbjct: 76  LKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVYET 135

Query: 112 CTAGCIYRGE 121
                +Y+GE
Sbjct: 136 DNNIVVYKGE 145


>UniRef50_Q1NNH1 Putative uncharacterized protein n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NNH1_9DELT
          Length = 122

 Score = 61.6 bits (148), Expect = 8e-09,   Method: Compositional matrix adjust.
 Identities = 38/120 (31%), Positives = 61/120 (50%), Gaps = 8/120 (6%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           +F +  F + H L + P    C + HGH++ V + +  +     G  +DF +LK A K  
Sbjct: 4   IFTESHFSSGHHLRNYPGN--CEKPHGHNWKVEVTVRADELDQLGMGLDFRDLKGAVKEV 61

Query: 66  YERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSA----VMVKETCTAGCIYR 119
            + LDH  LND P  +  NP+SE +A++I+ ++K  +         V V+ET   G  YR
Sbjct: 62  VDDLDHRDLNDHPAFQEINPSSENIARYIFVELKKRLQNDRCRPHKVTVRETDACGVTYR 121


>UniRef50_O29809 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=1
          Tax=Archaeoglobus fulgidus RepID=QUED_ARCFU
          Length = 115

 Score = 60.8 bits (146), Expect = 1e-08,   Method: Compositional matrix adjust.
 Identities = 34/87 (39%), Positives = 52/87 (59%), Gaps = 8/87 (9%)

Query: 11 TFEAAHRLPHVPEGHK-CGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
          +F AAH +P    GHK CG++HGH+F V +EI+G+V    G ++DF +LK        + 
Sbjct: 12 SFSAAHSIP----GHKKCGKVHGHNFKVEVEISGKV-KENGMVMDFFDLKRIVNEVVAKF 66

Query: 70 DHHYLNDIPGLENPTSEVLAKWIWDQV 96
          DH  LN+   +E PTSE +   I+ ++
Sbjct: 67 DHTLLNE--QIEIPTSENICLRIFSEL 91


>UniRef50_B8DNN3 Putative uncharacterized protein n=3 Tax=Desulfovibrio
           RepID=B8DNN3_DESVM
          Length = 130

 Score = 60.1 bits (144), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 43/116 (37%), Positives = 58/116 (50%), Gaps = 13/116 (11%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG---WIIDFAELKAAFKPTYER 68
           F A+H L H  EG KC  +HGH+F V  E+  E D  TG    ++DF  LK       + 
Sbjct: 14  FCASHALRHY-EG-KCESMHGHNFAV--EMVAEGDRLTGDTEIVLDFKVLKRELNAVLDT 69

Query: 69  LDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIY 118
           LDH  LND+   +  NP+SE L++ IW Q+ P +      L +V V E       Y
Sbjct: 70  LDHKNLNDVTPFDTINPSSENLSRHIWQQLAPRLAPHGVRLHSVTVSEKAAQSATY 125


>UniRef50_Q2LVK6 Queuosine biosynthesis protein n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVK6_SYNAS
          Length = 159

 Score = 60.1 bits (144), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 39/114 (34%), Positives = 60/114 (52%), Gaps = 8/114 (7%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F AAH L + P    C  LHGH++ V + +  E     G  IDF E+K + +    RLDH
Sbjct: 46  FSAAHALRNYPGN--CEHLHGHNWAVEVTVECEELNEIGIGIDFREVKQSVREALHRLDH 103

Query: 72  HYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCIYR 119
             LN++P     NP+SE +A+ +++++   +      +S V V ET T+   YR
Sbjct: 104 VNLNELPQFCDINPSSENIARHLYNELSRKLNTEKIRVSRVRVSETPTSKASYR 157


>UniRef50_Q46G73 6-pyruvoyltetrahydropterin synthase n=7 Tax=Euryarchaeota
          RepID=Q46G73_METBF
          Length = 117

 Score = 60.1 bits (144), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 37/81 (45%), Positives = 50/81 (61%), Gaps = 8/81 (9%)

Query: 13 EAAHRLPHVPEGH-KCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          ++AH LP    GH KCGR+HGH++ + + + GEV    G +IDF +LK   K T E  DH
Sbjct: 13 DSAHYLP----GHGKCGRVHGHTYKIEVLVEGEVRE-NGMVIDFYDLKKGIKETLEEYDH 67

Query: 72 HYLNDIPGLENPTSEVLAKWI 92
            LN+I  LE P+SE L + I
Sbjct: 68 ILLNEI--LEFPSSEHLCQHI 86


>UniRef50_Q30ZA2 6-pyruvoyl tetrahydrobiopterin synthase, putative n=3
           Tax=Desulfovibrionales RepID=Q30ZA2_DESDG
          Length = 130

 Score = 59.7 bits (143), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 37/92 (40%), Positives = 51/92 (55%), Gaps = 5/92 (5%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV-DPHTGWIIDFAELKAAFKPTYERLD 70
           F AAH L +     KC  LHGH+F V   + G +  P T  ++DF  LK A K   + LD
Sbjct: 14  FAAAHSLRNY--CGKCEALHGHNFGVEATVEGGILTPDTELLVDFKVLKNALKQVLDGLD 71

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV 100
           H  LN+ P  +  NP+SE LA+ I+  + P+V
Sbjct: 72  HCVLNETPPFDTCNPSSENLARHIYRHMAPLV 103


>UniRef50_C5A6K8 6-pyruvoyl tetrahydrobiopterin synthase (PtpS) n=9
           Tax=Thermococcaceae RepID=C5A6K8_THEGJ
          Length = 115

 Score = 58.9 bits (141), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 38/100 (38%), Positives = 54/100 (54%), Gaps = 7/100 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + + F FEAAH +  V EG +   +HGH+F  RLE+  E     G+++DF +L+  
Sbjct: 1   MRARIIERFKFEAAHSV--VVEG-RPEEIHGHTF--RLEVVVEGPLKNGYVMDFIQLRKI 55

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP 101
                 +LDH  LN I   ENPT+E LA WI  +    +P
Sbjct: 56  VGGIIGKLDHRNLNHI--FENPTTENLALWIAKETSRNLP 93


>UniRef50_P48611 6-pyruvoyl tetrahydrobiopterin synthase n=16 Tax=Eumetazoa
           RepID=PTPS_DROME
          Length = 168

 Score = 58.9 bits (141), Expect = 5e-08,   Method: Compositional matrix adjust.
 Identities = 44/132 (33%), Positives = 65/132 (49%), Gaps = 17/132 (12%)

Query: 6   LFKDFTFEAAHRL--PHVPEGH------KCGRLHGH--SFMVRLEITGEVDPHTGWIIDF 55
           L +  TF A HRL  P + +        KC   HGH  ++ V + + G +D  TG +++ 
Sbjct: 9   LTRRETFSACHRLHSPQLSDAENLEVFGKCNNFHGHGHNYTVEITVRGPIDRRTGMVLNI 68

Query: 56  AELKAAFKPT-YERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP---LLSAVMV 108
            ELK A +    +RLDH  L+ D+    N   T+E LA +IWD ++  +    LL  V +
Sbjct: 69  TELKEAIETVIMKRLDHKNLDKDVEYFANTPSTTENLAVYIWDNIRLQLKKPELLYEVKI 128

Query: 109 KETCTAGCIYRG 120
            ET      YRG
Sbjct: 129 HETPKNIISYRG 140


>UniRef50_A1HNF1 Putative uncharacterized protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HNF1_9FIRM
          Length = 130

 Score = 58.5 bits (140), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 45/114 (39%), Positives = 60/114 (52%), Gaps = 25/114 (21%)

Query: 8   KDFTFEAAHRLPHVPEGH--KCGRLHGHSFMVRLEITGEVD--------PHTGWIIDFAE 57
           K FTF+AAH LP    GH  KC ++HGH++  RLE+T E          P  G +IDF  
Sbjct: 10  KIFTFDAAHFLP----GHEGKCAQMHGHTY--RLEVTVERKDGGVATGGPEDGMVIDFGR 63

Query: 58  LKAAFKP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKE 110
           L A  K    ++LDH  LND      PTSE +A+ I+ +       LSA++  E
Sbjct: 64  LSALIKDRVVDKLDHKVLNDCFPFR-PTSENMARHIFIE-------LSAILANE 109


>UniRef50_A0B6A5 Putative uncharacterized protein n=1 Tax=Methanosaeta thermophila
          PT RepID=A0B6A5_METTP
          Length = 120

 Score = 58.5 bits (140), Expect = 6e-08,   Method: Compositional matrix adjust.
 Identities = 36/82 (43%), Positives = 52/82 (63%), Gaps = 7/82 (8%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-HTGWIIDFAELKAAFKPTYERLD 70
          F+AAH LP + +G KC R+HGH++  R+E+  + DP   G IIDF  LK       + LD
Sbjct: 9  FDAAHHLP-MHDG-KCSRIHGHTY--RVEVVLQGDPGDDGMIIDFYMLKKIVGRVIQELD 64

Query: 71 HHYLNDIPGLENPTSEVLAKWI 92
          H+ LN +  L+NPT+E++A  I
Sbjct: 65 HNNLNTV--LQNPTAEMIASHI 84


>UniRef50_C1CXM4 Putative 6-pyruvoyl tetrahydrobiopterin synthase, (PTP synthase)
          n=3 Tax=Bacteria RepID=C1CXM4_DEIDV
          Length = 136

 Score = 57.8 bits (138), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 43/101 (42%), Positives = 59/101 (58%), Gaps = 14/101 (13%)

Query: 2  MSTTLFKDFTFEAAHRLPHVPEGHK--CGRLHGHSFMVRLEIT-GEVDP-----HTGWII 53
          M  TL  +FTF++AH    V  G+   CGRLHGH++ VR+E+T   + P         + 
Sbjct: 1  MPWTLRTEFTFDSAH----VIAGYDGPCGRLHGHTYRVRMELTSSRLRPSAHVRRNIMVA 56

Query: 54 DFAELKAAFKP-TYERLDHHYLNDIPGL-ENPTSEVLAKWI 92
          DF  LK A K  T   LDH YLND+P L ++ T+EV+A +I
Sbjct: 57 DFRTLKWAKKDVTGGGLDHTYLNDVPELGDDTTAEVIAAYI 97


>UniRef50_A0L5B3 Putative uncharacterized protein n=1 Tax=Magnetococcus sp. MC-1
          RepID=A0L5B3_MAGSM
          Length = 142

 Score = 57.8 bits (138), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 35/92 (38%), Positives = 50/92 (54%), Gaps = 11/92 (11%)

Query: 10 FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG------EVDPHTGWIIDFAELKAAFK 63
          F FE+AHRLP+     KC RLHGHS+ + +  +G      E DP +G++ DF  +    K
Sbjct: 7  FKFESAHRLPY--HDGKCHRLHGHSYRLEMIFSGTVRQPDEKDPQSGFVADFGIVNDLVK 64

Query: 64 PTY--ERLDHHYLN-DIPGLENPTSEVLAKWI 92
                 LDH  LN  +PG+   ++E L+ WI
Sbjct: 65 EQLIDRYLDHRDLNASVPGIPYTSAEYLSAWI 96


>UniRef50_C8R1L5 Putative uncharacterized protein n=1 Tax=Desulfurivibrio
           alkaliphilus AHT2 RepID=C8R1L5_9DELT
          Length = 123

 Score = 57.8 bits (138), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 8/122 (6%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           +F    F + H L + P    C + HGH++ V++ +  +     G  +DF +LKAA K  
Sbjct: 4   VFTTTHFSSGHHLRNYPGN--CEKPHGHNWKVKVIMRADELDELGMALDFRDLKAALKVI 61

Query: 66  YERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLLS----AVMVKETCTAGCIYR 119
            + LDH  LN+ P    ENP+SE +A++I+ ++K  +         V V ET   G  Y 
Sbjct: 62  IDDLDHRDLNEHPAFQQENPSSENIARYIFAELKKSLSSDRYRPHKVTVLETDACGVSYS 121

Query: 120 GE 121
            E
Sbjct: 122 EE 123


>UniRef50_C7QN33 6-pyruvoyltetrahydropterin synthase n=3 Tax=Cyanobacteria
           RepID=C7QN33_CYAP0
          Length = 291

 Score = 57.8 bits (138), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 43/123 (34%), Positives = 62/123 (50%), Gaps = 16/123 (13%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPE---------GHKCGRLHGH--SFMVRLEITGEVDPHTG 50
           M  TL     F AAHRL  +PE           KC R+HGH  ++ + + +TGE+DP TG
Sbjct: 134 MKATLTIQTHFSAAHRLA-LPELTLEQNSEIYGKCARIHGHGHNYHLEVSVTGEIDPRTG 192

Query: 51  WIIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLSAV 106
            ++D   L+   K    E  DH +LN DIP      PT+E +A +I   ++  +  L A 
Sbjct: 193 MLVDLGILQQVVKDYVVEPFDHTFLNKDIPYFAQVVPTAENIALYIAQLLQTPIQQLGAE 252

Query: 107 MVK 109
           + K
Sbjct: 253 LDK 255



 Score = 47.0 bits (110), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 34/117 (29%), Positives = 62/117 (52%), Gaps = 15/117 (12%)

Query: 2   MSTTLFKDFTFEAAHR--LPHVPEGHK------CGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   + +   F A+HR  L  + E         C R   HGH++++ + + GE+D + G 
Sbjct: 1   MQCVINRRAQFSASHRYWLSELDEQENRLKFGDCTRFPGHGHNYVLYVSLLGEIDSY-GM 59

Query: 52  IIDFAELKAAFKPTY-ERLDHHYLNDI-PGLEN--PTSEVLAKWIWDQVKPVVPLLS 104
           + + + +K   K     +LD+ YLND+    ++  PT+E LA+ IW ++ P +PL++
Sbjct: 60  VENLSTVKRVIKEEITSQLDYCYLNDVWEEFQDSLPTTENLARVIWQRLAPHLPLVN 116


>UniRef50_C1SPF1 PreQ(0) biosynthesis protein QueD n=1 Tax=Denitrovibrio acetiphilus
           DSM 12809 RepID=C1SPF1_9BACT
          Length = 122

 Score = 57.8 bits (138), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 38/112 (33%), Positives = 54/112 (48%), Gaps = 6/112 (5%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           +F  AH L +     KC  LHGH++ V   + G+    T  ++DF  +K   K   E LD
Sbjct: 9   SFGGAHNLRNY--NGKCENLHGHNWKVEAYLKGDELNETEMLVDFTIMKKRLKEILETLD 66

Query: 71  HHYLN---DIPGLENPTSEVLAKWIWDQVKPVV-PLLSAVMVKETCTAGCIY 118
           H YLN   +   + NPTSE +A++I+  +K     L   V V ET      Y
Sbjct: 67  HKYLNEQVEFFKVNNPTSENIARYIYQGLKETFGKLTDRVAVWETDIQAAEY 118


>UniRef50_B2KC64 Putative uncharacterized protein n=1 Tax=Elusimicrobium minutum
           Pei191 RepID=B2KC64_ELUMP
          Length = 115

 Score = 57.4 bits (137), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 38/113 (33%), Positives = 56/113 (49%), Gaps = 11/113 (9%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F +AHRLP      +C  LHGH+++V   I GE    +G + DF  LK          DH
Sbjct: 9   FSSAHRLPDY--DGECNNLHGHTWVVEFIIEGET-KESGMVEDFKTLKPLLDSVLP--DH 63

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCIYRG 120
            YLND   ++NPT+E + K+I+D    ++      L  V + E   A  I++ 
Sbjct: 64  KYLNDF--VQNPTAENMVKYIYDNAAKLLTQRGLKLKQVELWENENASAIFQA 114


>UniRef50_A5D2E2 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Peptococcaceae
           RepID=A5D2E2_PELTS
          Length = 129

 Score = 57.0 bits (136), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 38/121 (31%), Positives = 65/121 (53%), Gaps = 17/121 (14%)

Query: 11  TFEAAHRLPHVPEGHK--CGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
           +F AAH +    +G+   C R+HGH+++V   + G      G ++DF E+K   +     
Sbjct: 9   SFAAAHSI----KGYDGPCSRMHGHTWLVEAVLRGGQLDQKGMLVDFKEVKNILRSAVGE 64

Query: 69  LDHHYLNDIPGL-----ENPTSEVLAKWIWDQVKP-VVPL-----LSAVMVKETCTAGCI 117
           LDH  LN+I        ++PT+E +A++++ ++KP +V L     L+ V V E+ TA   
Sbjct: 65  LDHQNLNEIKPFAGGSGDSPTAENIARYLFCRIKPEIVKLERNIHLAMVRVWESDTAAAS 124

Query: 118 Y 118
           Y
Sbjct: 125 Y 125


>UniRef50_A6LBJ5 6-pyruvoyl-tetrahydropterin synthase n=43 Tax=Bacteria
           RepID=A6LBJ5_PARD8
          Length = 110

 Score = 57.0 bits (136), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 9/114 (7%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           T+ K     A+H L  +    KC  LHGH++M+ +    +     G ++DF+ +K + K 
Sbjct: 3   TVIKRMEISASHSL-RLSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSVKS 61

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
               LDH  LNDI    NPT+E +A W+++Q    +P    V VKE+     IY
Sbjct: 62  L---LDHQNLNDILPF-NPTAENIAFWVYEQ----IPSCFKVEVKESEGNTAIY 107


>UniRef50_A3EQ19 Probable 6-pyruvoyl tetrahydrobiopterin synthase family protein n=3
           Tax=Leptospirillum RepID=A3EQ19_9BACT
          Length = 128

 Score = 56.6 bits (135), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 41/119 (34%), Positives = 60/119 (50%), Gaps = 13/119 (10%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGE-VDPHTGWIIDFAELKAAFKPTYERL 69
           TF A+H LP  P    C +LHGH++ V +  +   +DP  G  +DF E +A   P  + L
Sbjct: 9   TFAASHILPGYPG--LCSKLHGHNWTVEVSWSSRGLDP-LGMALDFHEAEALLGPLIKEL 65

Query: 70  DHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP-------LLSAVMVKETCTAGCIYR 119
           DH +LND P      PTSE +A +++ ++K ++         L  V V E      IYR
Sbjct: 66  DHSHLNDHPFFRERLPTSEQVAFFLYTRLKEIMSSRTDSTVRLDQVAVTEMAPYKAIYR 124


>UniRef50_B3T9P1 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG7F19 RepID=B3T9P1_9ARCH
          Length = 120

 Score = 56.6 bits (135), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 35/105 (33%), Positives = 58/105 (55%), Gaps = 9/105 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGW----IIDFAE 57
           M T +  +F  + AH L   P   KCG+ HGH+  + +E  GE+   + +    II+F E
Sbjct: 1   MQTKIGVEFEIDFAHTLKGHP---KCGKPHGHTARIIVEAAGELKNGSTYKDNMIIEFDE 57

Query: 58  LKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL 102
           +K     T ++LDH  L+ +   + PTSE +A WI++ +K  +P+
Sbjct: 58  MKKICWQTLQQLDHTNLDSM--FDFPTSENIAMWIFEHLKDKIPI 100


>UniRef50_Q6ARY1 Related to 6-pyruvoyl tetrahydropterin synthase n=1
           Tax=Desulfotalea psychrophila RepID=Q6ARY1_DESPS
          Length = 136

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 37/124 (29%), Positives = 67/124 (54%), Gaps = 19/124 (15%)

Query: 1   MMSTTLFKDFTFEAAHRL--------PHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWI 52
           M   T+ K+F F+AAH+L         +     KC +LHGH++ +R+ ITG+V P+ G +
Sbjct: 1   MAMLTITKEFRFDAAHKLFLKDLTDQENREAFGKCSQLHGHTYCLRITITGKVQPN-GMV 59

Query: 53  IDFAELKAAF-KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPLLSAVMVK 109
           ++F +LK    +    R DH +LN++    +   T+E ++ +I+        +L+A + K
Sbjct: 60  LNFTDLKQIVEEKIIARYDHSHLNELEEYRDLPTTAENMSLYIF-------KVLAACLKK 112

Query: 110 ETCT 113
           +  T
Sbjct: 113 QKVT 116


>UniRef50_C6VZC4 Putative uncharacterized protein n=3 Tax=Sphingobacteriales
           RepID=C6VZC4_DYAFD
          Length = 138

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 37/115 (32%), Positives = 61/115 (53%), Gaps = 16/115 (13%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGH---------KCGR--LHGHSFMVRLEITGEVDPHT 49
           + +  +F+   F AAHRL H P            KC     HGH++ + +++TG +DP T
Sbjct: 2   VQNVAVFRKEHFNAAHRL-HNPAWSDEQNEAVFGKCNNPSFHGHNYELIVQVTGPLDPET 60

Query: 50  GWIIDFAELKAAFKPTY-ERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVV 100
           G+++D   L A  K +  +R DH  LN D+   +  NPT+E +A  I+  ++P +
Sbjct: 61  GYVMDMKLLSAILKESVIDRFDHRNLNLDVEEFKTLNPTAENIAIVIYSIIRPKI 115


>UniRef50_UPI0001B56D65 putative 6-pyruvoyl tetrahydropterin synthase n=1
          Tax=Streptomyces sp. C RepID=UPI0001B56D65
          Length = 146

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 31/77 (40%), Positives = 47/77 (61%), Gaps = 2/77 (2%)

Query: 5  TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT--GWIIDFAELKAAF 62
          T+ K+F F A+H L  +P  H C R+HGH+++V LE+ G  +  T  G++ D+ +L A  
Sbjct: 3  TITKEFHFSASHVLDRLPGWHPCARMHGHNYVVVLELRGRREDLTEAGFVRDYRDLDAFK 62

Query: 63 KPTYERLDHHYLNDIPG 79
          K   E LDH +LN+  G
Sbjct: 63 KWVDETLDHRHLNEAMG 79


>UniRef50_A7BS03 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Beggiatoa sp. PS
           RepID=A7BS03_9GAMM
          Length = 148

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 23/129 (17%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL-D 70
           +E AHRL H     KC  +HGHS    +E+        G+++DFA++K   K    +  D
Sbjct: 12  YEYAHRLLH--HTGKCRHVHGHSGEAIIELASNTLNDNGFVMDFADVKTPLKKWINQFWD 69

Query: 71  HHYLND-----IPGL-----------ENPTSEVLAKWIWDQV----KPVVPLLSAVMVKE 110
           H YL +     +P             E PT+EV+A+ +++Q     +P   +L+ V ++E
Sbjct: 70  HAYLANESDPLLPAFKSENMNIYTFPEEPTAEVMARHLFEQAAILERPPGVILTRVTIRE 129

Query: 111 TCTAGCIYR 119
           TCT    Y+
Sbjct: 130 TCTGQASYQ 138


>UniRef50_Q3ZW85 6-pyruvoyl tetrahydrobiopterin synthase n=5 Tax=Dehalococcoides
           RepID=Q3ZW85_DEHSC
          Length = 123

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 37/92 (40%), Positives = 52/92 (56%), Gaps = 6/92 (6%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEI-TGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           FEAAH L       KC  LHGH + V L++ TGE+D   G   DF+ LK       +  D
Sbjct: 10  FEAAHFLRGYK--GKCENLHGHRYEVALKVKTGELD-ECGMGADFSLLKTRLNEVLQSYD 66

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV 100
           H  LND+   +  NP++E +AK I+D++K V+
Sbjct: 67  HTCLNDLTPFDNINPSAENIAKDIYDKLKTVI 98


>UniRef50_B8FMW4 Queuosine biosynthesis protein QueD n=3 Tax=Proteobacteria
           RepID=B8FMW4_DESAA
          Length = 126

 Score = 56.2 bits (134), Expect = 3e-07,   Method: Compositional matrix adjust.
 Identities = 40/113 (35%), Positives = 55/113 (48%), Gaps = 8/113 (7%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F AAH L        C R+HGH++MV + I        G  IDF ++K A +   + LDH
Sbjct: 13  FSAAHALTGYDG--DCSRIHGHNWMVEVSIQCRKLDDVGIGIDFKDVKDAVEEITQGLDH 70

Query: 72  HYLNDIPGLE--NPTSEVLAKWIWDQ----VKPVVPLLSAVMVKETCTAGCIY 118
             LND P  +  NPTSE +A +++ Q    +      +S V V E   AG  Y
Sbjct: 71  CMLNDHPAFQSVNPTSENVAMFLYKQLGSHLNNEYTKVSRVKVFEAPGAGAAY 123


>UniRef50_UPI0001B56179 putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Streptomyces
           sp. AA4 RepID=UPI0001B56179
          Length = 264

 Score = 55.8 bits (133), Expect = 4e-07,   Method: Compositional matrix adjust.
 Identities = 35/81 (43%), Positives = 46/81 (56%), Gaps = 5/81 (6%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           F FEAAH L  +PEGHKCGR HGHS+ V L +  +  P     +     +  +   Y  L
Sbjct: 148 FAFEAAHHLEGLPEGHKCGRPHGHSYRVDLRLDQQTSPRRRARLRSRLAE--YLDRY--L 203

Query: 70  DHHYLNDIPGLENPTSEVLAK 90
           DH  LN +  L+ PTSE+LA+
Sbjct: 204 DHRDLNAVLELQ-PTSELLAE 223



 Score = 47.4 bits (111), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 31/84 (36%), Positives = 46/84 (54%), Gaps = 2/84 (2%)

Query: 10  FTFEAAHRLPHVPEG-HKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
           F+F AAH L + P   +K GR HGH+F V +E+T       G++ D+AEL    +     
Sbjct: 28  FSFAAAHHLANPPATENKAGRPHGHTFTVEVELTDTELRAPGFVADYAELAPVGEYLKRE 87

Query: 69  LDHHYLNDIPGLENPTSEVLAKWI 92
           LDH  LN +   +  T++ LA+ I
Sbjct: 88  LDHRDLNALFTFDT-TTDALAQHI 110


>UniRef50_D2ML00 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
           Poribacteria sp. WGA-A3 RepID=D2ML00_9BACT
          Length = 143

 Score = 55.5 bits (132), Expect = 5e-07,   Method: Compositional matrix adjust.
 Identities = 35/107 (32%), Positives = 49/107 (45%), Gaps = 13/107 (12%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRL----------HGHSFMVRLEITGEVDPHTGWIIDFAE 57
           + + F AAHRL          R           HGH + V + +TGE+DP TG + D   
Sbjct: 9   RQYRFCAAHRLHTDALSDDVNRKVYDKCNNPNGHGHDYTVFVTVTGELDPQTGEVTDIHA 68

Query: 58  LKAAF-KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP 101
           L     +   ER DH +LN  P  +    T E L K+IWD++   +P
Sbjct: 69  LDGLVNRKIVERFDHRHLNHDPAFQQLVTTGENLVKFIWDELVDDIP 115


>UniRef50_D1JB18 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=2
          Tax=uncultured archaeon RepID=D1JB18_9ARCH
          Length = 120

 Score = 55.1 bits (131), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 31/78 (39%), Positives = 45/78 (57%), Gaps = 4/78 (5%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          F AAH LP      KC  LHGH++ V + + GE    T  + DF+E+KA  +   + +DH
Sbjct: 9  FSAAHSLPR--HTGKCKNLHGHTYRVDIVVEGEKKKDTECVADFSEVKALVEEVLDLVDH 66

Query: 72 HYLNDIPGLENPTSEVLA 89
           +LN+I  +  PTSE +A
Sbjct: 67 KHLNEI--IAYPTSENIA 82


>UniRef50_Q979P1 Putative uncharacterized protein TVG1150731 n=2 Tax=Thermoplasma
          RepID=Q979P1_THEVO
          Length = 159

 Score = 55.1 bits (131), Expect = 8e-07,   Method: Compositional matrix adjust.
 Identities = 28/76 (36%), Positives = 41/76 (53%), Gaps = 7/76 (9%)

Query: 7  FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
          + +  F AAH    +P  +KC RLHGH + + + + GE+    G +IDF ELK A +   
Sbjct: 9  YTNMRFSAAH---FIPSHYKCSRLHGHDYGIIINVDGEM--QDGMLIDFIELKNAIRSVI 63

Query: 67 ERLDHHYLNDIPGLEN 82
            +DH  L  +PG  N
Sbjct: 64 NEMDHKLL--VPGKAN 77


>UniRef50_Q8Z0L1 Alr0080 protein n=5 Tax=Cyanobacteria RepID=Q8Z0L1_ANASP
          Length = 128

 Score = 54.7 bits (130), Expect = 9e-07,   Method: Compositional matrix adjust.
 Identities = 40/120 (33%), Positives = 63/120 (52%), Gaps = 12/120 (10%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEI------TGEVDPHTGWIIDFAELKAAF 62
           +F+F +AH +        CGR+HGH++ VR+E       + +  PH   + DF  L+ A 
Sbjct: 9   EFSFNSAHYIKDY--NGPCGRMHGHNYQVRIEAISTQLHSSQYCPHPVMVADFRTLRWAK 66

Query: 63  KP-TYERLDHHYLNDI-PGLENPTSEVLAKWIWDQVKPVVP--LLSAVMVKETCTAGCIY 118
           +  T   LDH  LN++ P     T+E++AK+I+D+ K  VP  +   V V ET  +   Y
Sbjct: 67  QDVTKGGLDHGILNEVMPPEYETTAEMIAKYIYDETKKRVPPDVQLKVNVSETPNSWVEY 126


>UniRef50_Q3J9J8 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Chromatiales
           RepID=Q3J9J8_NITOC
          Length = 99

 Score = 54.7 bits (130), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 31/95 (32%), Positives = 52/95 (54%), Gaps = 6/95 (6%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIP--GLENPTSEV 87
           +HGH++ + +E+T +     G ++DF ++K + +    +LDH YLNDI    L NPT+E 
Sbjct: 1   MHGHNWKLEVEVTAQALDQQGMVMDFKDIKESARELCAQLDHRYLNDISPFDLINPTAEN 60

Query: 88  LAKWIW----DQVKPVVPLLSAVMVKETCTAGCIY 118
           LA + +     Q+      +SA+ + ET  A   Y
Sbjct: 61  LAAFFYRGLSKQLNNERARVSAITLWETERACVRY 95


>UniRef50_A2BZT2 6-pyruvoyl tetrahydropterin synthase n=48 Tax=cellular organisms
           RepID=A2BZT2_PROM1
          Length = 308

 Score = 54.3 bits (129), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 38/112 (33%), Positives = 58/112 (51%), Gaps = 14/112 (12%)

Query: 12  FEAAHRLPH--VPEGH------KCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL    +P+        KC R   HGH+++V + + G+++P TG I D + L + 
Sbjct: 162 FSAAHRLAREDLPQTENEKIFGKCARPNGHGHNYLVDITVKGKINPRTGMICDLSALNSL 221

Query: 62  FKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLSAVMVK 109
                 E  DH +LN DIP   N  PT+E +A  I D++   +  + A + K
Sbjct: 222 INDLVVEPFDHTFLNKDIPYFANCVPTAENIALHISDKLTNPINAIGANLYK 273



 Score = 40.0 bits (92), Expect = 0.021,   Method: Compositional matrix adjust.
 Identities = 30/112 (26%), Positives = 56/112 (50%), Gaps = 20/112 (17%)

Query: 12  FEAAH--RLPHVPEGHKCGRL--------HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F A+H  RLP + +               HGH++ + + + G+++ + G +++ +++K A
Sbjct: 24  FSASHLYRLPELSDDDNSALFGPCSIAPGHGHNYELIVTMEGDLNKY-GMVLNLSDVKYA 82

Query: 62  FK-PTYERLDHHYLNDI--------PGLENPTSEVLAKWIWDQVKPVVPLLS 104
            K     +LD  +LND         P    PT+E L + IW+++K  +PL S
Sbjct: 83  IKNEVTSQLDFRFLNDTWPEFDLSKPEGCLPTTESLVRIIWERLKSHLPLKS 134


>UniRef50_A3ZTI8 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Planctomycetaceae
           RepID=A3ZTI8_9PLAN
          Length = 167

 Score = 53.9 bits (128), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 38/116 (32%), Positives = 55/116 (47%), Gaps = 21/116 (18%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           MS  + +   F A HRL     G KC   HGH+++    +T +     G +IDFA+LKA 
Sbjct: 9   MSLVIMRRIKFCAGHRL--YKHGGKCEFFHGHNYVADFYVTADEVDDVGRVIDFADLKAK 66

Query: 62  FKP-TYERLDHHYL------NDIPGLE------------NPTSEVLAKWIWDQVKP 98
           FK    E  DH +L      N I  ++            NPT+E +A+++ D V P
Sbjct: 67  FKGWLDEHWDHGFLLSEQDENGINAIKQVVPCKYFVMPYNPTAENMARYLLDYVCP 122


>UniRef50_B0TFF5 6-pyruvoyl-tetrahydropterin synthase, putative n=2
          Tax=Clostridiales RepID=B0TFF5_HELMI
          Length = 130

 Score = 53.9 bits (128), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 31/87 (35%), Positives = 48/87 (55%), Gaps = 4/87 (4%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          F+AAH L   P    C R+HGH++ V + + G      G +IDF E+K A K   ++LDH
Sbjct: 10 FDAAHYLRDYPG--DCARVHGHTWQVEVTLVGRQLDDLGMLIDFKEVKKAVKAICDQLDH 67

Query: 72 HYLN--DIPGLENPTSEVLAKWIWDQV 96
            +N  D     NPT+E L+ + + ++
Sbjct: 68 RMINEHDYFLQRNPTAENLSCYFFHEL 94


>UniRef50_B1GYR9 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
          Tax=uncultured Termite group 1 bacterium phylotype
          Rs-D17 RepID=B1GYR9_UNCTG
          Length = 122

 Score = 53.1 bits (126), Expect = 2e-06,   Method: Compositional matrix adjust.
 Identities = 30/91 (32%), Positives = 48/91 (52%), Gaps = 4/91 (4%)

Query: 11 TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
          +F +AH L       +C  LHGH++ +R    G     TG +IDF ++K         LD
Sbjct: 10 SFSSAHCLREYK--GRCENLHGHNWKIRAAFYGTELDDTGVLIDFMDIKMHLNKVINYLD 67

Query: 71 HHYLNDIPGLE--NPTSEVLAKWIWDQVKPV 99
          H +LN+I   +  NPT+E +A +I  ++K +
Sbjct: 68 HKFLNEIVPFDRVNPTAENIAAFILGRLKDI 98


>UniRef50_Q90W95 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Deuterostomia
           RepID=PTPS_POERE
          Length = 147

 Score = 52.8 bits (125), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 32/97 (32%), Positives = 53/97 (54%), Gaps = 6/97 (6%)

Query: 31  HGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE-RLDHHYLN-DIPGLEN--PTSE 86
           HGH++ V + + G++DP TG +++  +LK   +      LDH  L+ D+P   +   T+E
Sbjct: 51  HGHNYKVEVTVRGKIDPVTGMVMNLTDLKKCIEEVIMIPLDHKNLDKDVPYFADVVSTTE 110

Query: 87  VLAKWIWDQVKPVVP--LLSAVMVKETCTAGCIYRGE 121
            LA +IWD +   +P  L   + + ET     +YRGE
Sbjct: 111 NLAVYIWDNMAKALPASLPYEIRIHETDKNIVVYRGE 147


>UniRef50_O02058 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=10
           Tax=Fungi/Metazoa group RepID=PTPS_CAEEL
          Length = 140

 Score = 52.8 bits (125), Expect = 3e-06,   Method: Compositional matrix adjust.
 Identities = 37/126 (29%), Positives = 66/126 (52%), Gaps = 16/126 (12%)

Query: 11  TFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           +F AAHRL         +     KC     HGH+++ ++++ GEVDP +G + D A+LK 
Sbjct: 14  SFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSGMVYDLAKLKK 73

Query: 61  AFKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV---PLLSAVMVKETCTA 114
                 + +DH  L+ D+   +    TSE +A ++++++K V+    +L  V ++ET   
Sbjct: 74  EMSLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMFEKLKSVMSNPSVLYKVTIEETPKN 133

Query: 115 GCIYRG 120
              Y+G
Sbjct: 134 IFTYKG 139


>UniRef50_C0N3T5 6-pyruvoyl tetrahydropterin synthase superfamily n=2
           Tax=Gammaproteobacteria RepID=C0N3T5_9GAMM
          Length = 98

 Score = 52.8 bits (125), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 6/98 (6%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLE--NPTSEV 87
           +HGH++ + +E+T       G  +DF  +K A +   + LDH YLNDIP  +  NPT+E 
Sbjct: 1   MHGHNWKLEVEVTATALNEHGMGMDFKTIKTAARELAKTLDHRYLNDIPPFDTVNPTAEN 60

Query: 88  LAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYRGE 121
           +A++ + ++   +      +S V + ET  A   Y  E
Sbjct: 61  IAQYFYQKLSGTLNNETAKISGVTLWETDRACVKYSEE 98


>UniRef50_Q8TX57 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TX57_METKA
          Length = 160

 Score = 52.4 bits (124), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 36/105 (34%), Positives = 58/105 (55%), Gaps = 12/105 (11%)

Query: 10  FTFEAAHRLPHVPEGH-KCGRLHGHSFMVRLEITGE-VDPHTGWIIDFAELKAAFKPTYE 67
             F A H +P    GH KCGRLHGH++ V +E+ GE  +PH G++ DF ELK+  +   +
Sbjct: 13  LRFSACHVIP----GHGKCGRLHGHTYHVSVELLGERTEPH-GFVYDFDELKSTVRELIK 67

Query: 68  RLDHHYL----NDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV 108
            LDH  L    +++  +E   +E+  + + D  + V P    V++
Sbjct: 68  PLDHRVLLPTESELFEIEESGNEITVR-LSDGKRYVFPREDVVLI 111


>UniRef50_UPI0001C1695B hypothetical protein CRD_00116 n=2 Tax=Nostocaceae
           RepID=UPI0001C1695B
          Length = 422

 Score = 52.4 bits (124), Expect = 4e-06,   Method: Compositional matrix adjust.
 Identities = 32/116 (27%), Positives = 62/116 (53%), Gaps = 15/116 (12%)

Query: 2   MSTTLFKDFTFEAAHR--LPHVPEGHKCGRL--------HGHSFMVRLEITGEVDPHTGW 51
           M   + +   F A+HR  LP + E    G+         HGH++++ + ++GE+D + G 
Sbjct: 1   MECIINRRAQFSASHRYWLPELGEAQNVGKFGLCAKFPGHGHNYVLFISMSGELDEY-GM 59

Query: 52  IIDFAELKAAFKP-TYERLDHHYLNDI---PGLENPTSEVLAKWIWDQVKPVVPLL 103
           +++ +++K   K      LD  YLN++        PT+E +A+ IW+++ P +PL+
Sbjct: 60  VLNLSDVKQVIKSEVTSELDFSYLNEVWEEFQATLPTTENIARVIWNRLTPHLPLV 115



 Score = 49.7 bits (117), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 32/95 (33%), Positives = 50/95 (52%), Gaps = 9/95 (9%)

Query: 12  FEAAHRLP---HVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAEL-KAAFKPTYE 67
           F AAHRL       +  KC R HGH++ + + + GE+D  TG I+D   L +   +   E
Sbjct: 144 FSAAHRLAPNLRAEKYGKCTRTHGHNYHLEVTVEGEMDGRTGTIVDLGCLHETVEREILE 203

Query: 68  RLDHHYLN-DIPGLEN----PTSEVLAKWIWDQVK 97
             DH  +N DIP        PT+E +A+++ D ++
Sbjct: 204 LFDHSCINEDIPYFSTSHIVPTTENIARYMSDLLQ 238



 Score = 46.6 bits (109), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 36/112 (32%), Positives = 56/112 (50%), Gaps = 14/112 (12%)

Query: 12  FEAAHRLP----HVPEGH----KCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL      + +      KC R+  HGH++ + + + GE+D  TG  +D   L   
Sbjct: 278 FSAAHRLADPTLSLEKNQTIYGKCSRINGHGHNYHLEVTVRGEIDSVTGMSVDLVGLNQI 337

Query: 62  FKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLSAVMVK 109
            +    E +DH +LN D+P      PT+E +A +I D V+  +  L A + K
Sbjct: 338 IQHYVIEPMDHSFLNQDLPYFTEVVPTAENIAVYISDVVRSPIEELGAKLHK 389


>UniRef50_B5I9Q5 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Aciduliprofundum
          boonei T469 RepID=B5I9Q5_9EURY
          Length = 160

 Score = 52.0 bits (123), Expect = 6e-06,   Method: Compositional matrix adjust.
 Identities = 29/65 (44%), Positives = 34/65 (52%), Gaps = 5/65 (7%)

Query: 10 FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
            F A+H    +P  HKC RLHGH + VRL I GE   H   + DF ELK   +   E L
Sbjct: 12 LKFSASH---FIPSHHKCSRLHGHDYGVRLRIFGETKDHI--LYDFVELKNEVRSLCEEL 66

Query: 70 DHHYL 74
          DH  L
Sbjct: 67 DHKLL 71


>UniRef50_A8Y1U6 C. briggsae CBR-PTPS-1 protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8Y1U6_CAEBR
          Length = 132

 Score = 51.6 bits (122), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 16/125 (12%)

Query: 12  FEAAHRLPH----VPEGH----KCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL      V E      KC     HGH+++ ++++ GEVDP +G + D A+LK  
Sbjct: 7   FSAAHRLNSENLSVAENKETFGKCNNDNGHGHNYVWKVKLRGEVDPVSGMVYDLAKLKKE 66

Query: 62  FKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV---PLLSAVMVKETCTAG 115
                + +DH  L+ D+   +    TSE +A +++ ++K V+    +L    ++ET    
Sbjct: 67  MNLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMYQKLKSVMSNPSVLYKCTIEETPKNV 126

Query: 116 CIYRG 120
             Y+G
Sbjct: 127 FTYKG 131


>UniRef50_Q6B324 6-pyruvoyl tetrahydropterin synthase (Fragment) n=6 Tax=Eumetazoa
           RepID=Q6B324_DANRE
          Length = 143

 Score = 51.6 bits (122), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 33/99 (33%), Positives = 55/99 (55%), Gaps = 14/99 (14%)

Query: 31  HGHSFMVRLEITGEVDPHTGWIIDFAELK-----AAFKPTYERLDHHYLN-DIPGLEN-- 82
           HGH++ V + + G++D +TG +++  +LK     A  KP    LDH  L+ D+P   +  
Sbjct: 49  HGHNYTVEVTVRGKIDKNTGMVMNLTDLKEFIEEAVMKP----LDHKNLDLDVPYFADVV 104

Query: 83  PTSEVLAKWIWDQVKPVVP--LLSAVMVKETCTAGCIYR 119
            T+E L+ +IWD ++ ++P   L  + V ET     IYR
Sbjct: 105 STTENLSVFIWDGLQKLLPHDSLYEIKVYETAKNIVIYR 143


>UniRef50_Q3A420 6-pyruvoyl-tetrahydropterin synthase n=7 Tax=Bacteria
          RepID=Q3A420_PELCD
          Length = 122

 Score = 51.6 bits (122), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 32/91 (35%), Positives = 52/91 (57%), Gaps = 6/91 (6%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEI-TGEVDPHTGWIIDFAELKAAFKPTYERLD 70
          F AAH L +      C  LHGH++ V + + T E+D   G  +DF  LK       + LD
Sbjct: 10 FAAAHNLMNYQ--GDCENLHGHNWKVEVTVATRELDK-AGLGVDFKILKKETNRILDLLD 66

Query: 71 HHYLNDIPGLE--NPTSEVLAKWIWDQVKPV 99
          H YLND+P  +  +P+SE +A+++++++  V
Sbjct: 67 HKYLNDLPFFKGISPSSENIARFVFEELSKV 97


>UniRef50_UPI0001C418E1 queuosine biosynthesis protein QueD n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C418E1
          Length = 119

 Score = 51.6 bits (122), Expect = 8e-06,   Method: Compositional matrix adjust.
 Identities = 36/117 (30%), Positives = 59/117 (50%), Gaps = 7/117 (5%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG---EVDPHTGWIIDFAELKAA 61
           TL  +      H+L    +G KC + HGH + V L +     ++D +   I+D  +++A 
Sbjct: 3   TLVSEHRIYGCHKLK--DQGGKCTQWHGHQYRVILTLQAPYKDLD-YRNMIMDTYDIEAI 59

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
           F   +  +DH  LN+    ENPT E ++K+ +D +K  +  L +V V ET   G  Y
Sbjct: 60  FNE-FIGVDHLNLNEFMDSENPTMEEMSKFFYDGLKDKIECLVSVGVYETPETGVTY 115


>UniRef50_UPI000038E306 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=Ferroplasma
          acidarmanus fer1 RepID=UPI000038E306
          Length = 157

 Score = 51.2 bits (121), Expect = 9e-06,   Method: Compositional matrix adjust.
 Identities = 27/80 (33%), Positives = 41/80 (51%), Gaps = 6/80 (7%)

Query: 7  FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           K  T+ + H   +VP+  KC   HGH + + + I  +    +G  IDF  +K A KP  
Sbjct: 10 LKGLTWSSGH---YVPDNEKCKNFHGHDYSIDVIIDSDGVKASGMAIDFTIVKQAIKPVI 66

Query: 67 ERLDHHYL---NDIPGLENP 83
          E +DH ++   +DI   ENP
Sbjct: 67 ENMDHKFMIPEDDIRQNENP 86


>UniRef50_B9EM09 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=Coelomata
           RepID=B9EM09_SALSA
          Length = 204

 Score = 51.2 bits (121), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 17/127 (13%)

Query: 11  TFEAAHRLPHVPEGH---------KCGRLHGHSFMVR-LEITGEVDPHTGWIIDFAELKA 60
           +F A HRL H P            KC   +GH    + + + G++D HTG +++  +LK 
Sbjct: 79  SFSACHRL-HSPTLSDEVNKRIFGKCNNPNGHGHNYKEVTVRGKIDRHTGMVMNITDLKQ 137

Query: 61  AFKPTYER-LDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMVKETCTA 114
             +      LDH  L+ D+P   N   T+E +A +IWD +   +P  LL  V + ET   
Sbjct: 138 HIEEVIMIPLDHKNLDKDVPYFANVVSTTENVAVYIWDNMVKQLPANLLYEVKIHETDKN 197

Query: 115 GCIYRGE 121
             +YRGE
Sbjct: 198 IVVYRGE 204


>UniRef50_D1NB55 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Victivallis vadensis
          ATCC BAA-548 RepID=D1NB55_9BACT
          Length = 123

 Score = 50.8 bits (120), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 28/90 (31%), Positives = 46/90 (51%), Gaps = 4/90 (4%)

Query: 9  DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
          D +F AAH+L        C +LHGH++ + + +        G  +DF +LKA        
Sbjct: 7  DRSFSAAHQLR--GYNGDCCKLHGHNYKITVTVRSSELDEIGIALDFKKLKAELDALLAE 64

Query: 69 LDHHYLNDIPGLE--NPTSEVLAKWIWDQV 96
           DH  L+++   +  NPTSE LA+ I+ ++
Sbjct: 65 YDHSNLSELADFQAVNPTSENLARTIYRKI 94


>UniRef50_C1DVU3 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=Aquificales
           RepID=C1DVU3_SULAA
          Length = 115

 Score = 50.8 bits (120), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 39/100 (39%), Positives = 53/100 (53%), Gaps = 5/100 (5%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F AAH L       K   LHGH++MV L I  +   + G   DF E+K   K      D+
Sbjct: 11  FNAAHFLTDY--HGKPEPLHGHTWMVELYIKADKLDNGGMGYDFLEIKDLLKEILP--DY 66

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKET 111
             +NDI    +P++E +AK+I+DQVK   P L  V+V ET
Sbjct: 67  KCMNDIYDF-SPSAENVAKYIYDQVKKKYPTLVKVVVWET 105


>UniRef50_P44123 6-carboxy-5,6,7,8-tetrahydropterin synthase n=31
           Tax=Pasteurellaceae RepID=QUED_HAEIN
          Length = 141

 Score = 50.8 bits (120), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 39/139 (28%), Positives = 75/139 (53%), Gaps = 31/139 (22%)

Query: 8   KDFTFEAAHRLPHVPEGH--KCGRLHGHSFMVRLEITGEV---DPHTGWIIDFAELKAAF 62
           K+F+F+ AH L    +GH  KC  LHGH++ +++EI+G++         +IDF++LK+  
Sbjct: 6   KEFSFDMAHLL----DGHDGKCQNLHGHTYKLQVEISGDLYKSGAKKAMVIDFSDLKSIV 61

Query: 63  KPT-YERLDHHYLND------------IPGLENP--------TSEVLAKWIWDQVKPVVP 101
           K    + +DH ++ D            +  L +         T+E +A++I++++K    
Sbjct: 62  KKVILDPMDHAFIYDQTNERESQIATLLQKLNSKTFGVPFRTTAEEIARFIFNRLKHDEQ 121

Query: 102 L-LSAVMVKETCTAGCIYR 119
           L +S++ + ET T+ C Y+
Sbjct: 122 LSISSIRLWETPTSFCEYQ 140


>UniRef50_Q2PY17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bacteria
           RepID=Q2PY17_9BACT
          Length = 137

 Score = 50.1 bits (118), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 39/128 (30%), Positives = 62/128 (48%), Gaps = 18/128 (14%)

Query: 12  FEAAHRLPH---------VPEGHKCGRL-HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL +            GH      HGH+F + + + GEV+  TG++++  +LKA 
Sbjct: 10  FSAAHRLANPSWSDEKNQAVFGHCANEYSHGHNFQLIVTVKGEVNTDTGFVMNMVDLKAI 69

Query: 62  FKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVK-PVV---PLLSAVMVKETCT 113
                 + +DH  LN D+P ++   P++E LA   W Q++ P+      L  + + ET  
Sbjct: 70  MDSEIIQHVDHRNLNHDVPFMQGIMPSTENLAMIFWQQIEGPIAKHGAALHCIRIVETEN 129

Query: 114 AGCIYRGE 121
               Y GE
Sbjct: 130 NMVEYYGE 137


>UniRef50_A0M3Y1 Conserved tetrahydrobiopterin biosynthesis-like protein n=22
           Tax=Bacteroidetes RepID=A0M3Y1_GRAFK
          Length = 136

 Score = 50.1 bits (118), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 42/136 (30%), Positives = 66/136 (48%), Gaps = 16/136 (11%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGR--LHGHSFMVRLEITGEVDPHTGW 51
           M  T+ +   F AAHRL         +     KC     HGH++ + + +TGE DP TG+
Sbjct: 1   MRITVHRKAHFNAAHRLYRKDWDDERNFGVFGKCSNPHYHGHNYELIVSVTGEPDPETGF 60

Query: 52  IIDFAELKA-AFKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLS--A 105
           ++D   LK   +    E  DH  LN ++P  E+  PT+E +A  IW++++  +       
Sbjct: 61  VMDLKILKELIYLEVEEAFDHKNLNVEVPEFEDLIPTAEHIAVVIWNKLRTRIQEDHDLK 120

Query: 106 VMVKETCTAGCIYRGE 121
           V + ET      Y+GE
Sbjct: 121 VTLYETPRNFVSYKGE 136


>UniRef50_Q7UGM2 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Rhodopirellula
           baltica RepID=Q7UGM2_RHOBA
          Length = 137

 Score = 50.1 bits (118), Expect = 2e-05,   Method: Compositional matrix adjust.
 Identities = 36/113 (31%), Positives = 55/113 (48%), Gaps = 21/113 (18%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP-T 65
            + FTF + HRL  V    KC  LHGH++++ + +TGE     G I+DF +LK   K   
Sbjct: 1   MRRFTFCSGHRL--VGHEGKCQNLHGHNYVLEVYVTGEEQDAIGRILDFKQLKTRCKNWI 58

Query: 66  YERLDHHYL---NDIPGLE---------------NPTSEVLAKWIWDQVKPVV 100
            E  DH ++    D  GL+               NPT+E +AK   +++ P +
Sbjct: 59  DENWDHTFVLWKKDQNGLDAIRSSEPHRIYELESNPTAENMAKHFLEKICPSI 111


>UniRef50_O66626 6-carboxy-5,6,7,8-tetrahydropterin synthase n=8 Tax=Aquificales
           RepID=QUED_AQUAE
          Length = 162

 Score = 49.7 bits (117), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 44/162 (27%), Positives = 71/162 (43%), Gaps = 42/162 (25%)

Query: 2   MSTTLFKDFTFEAAHRL--PHVPEG-----------HKCGRLHGHSFMVRLEITGEVDPH 48
           M   + K F FEA HR+   ++  G           +KC  LHGHS+++ + +  +    
Sbjct: 1   MKWEISKTFRFEAGHRVWKQNLTYGRGAQFTKEKPVNKCVNLHGHSYVLEVTVGSDTLSE 60

Query: 49  TGWIIDFAELKAAFKPTYERLDHHYLNDI-----PGLEN----------------PTSEV 87
              ++DF  +K A K   E +DH ++ D+     P L++                PT+E 
Sbjct: 61  QDMVMDFYHVKNALKGLIEEIDHSFIIDVNDPMYPELKDVAEKYGAMKIFPVEFCPTAEA 120

Query: 88  LAKWIWDQVKPVVP---LLSAVMVK-----ETCTAGCIYRGE 121
           LAK+ +D +K  +    LL  V V      ET T+   Y+ E
Sbjct: 121 LAKFFYDFLKKRLEEAGLLGEVKVVKVVLWETATSKAEYKEE 162


>UniRef50_C1AB96 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1AB96_GEMAT
          Length = 151

 Score = 49.3 bits (116), Expect = 3e-05,   Method: Compositional matrix adjust.
 Identities = 36/125 (28%), Positives = 59/125 (47%), Gaps = 16/125 (12%)

Query: 1   MMSTTLFKDFTFEAAHRL--PHVPEGHKCG--------RLHGHSFMVRLEITGEVDPHTG 50
           M  T+L +   F AAHR   P   +               HGH+++  + + G VD  TG
Sbjct: 10  MPRTSLTRRVLFAAAHRYRRPDWSDQENADVFGACAHPNYHGHTYLCDVTVAGPVDEETG 69

Query: 51  WIIDFAELKAAF-KPTYERLDHHYLN-DIP----GLENPTSEVLAKWIWDQVKPVVPLLS 104
           +++D   L     +   ER DH  +N D+P    G   PT E LA++I ++V+  +   +
Sbjct: 70  FVVDLGFLDRVLQREVRERFDHRNINLDVPEFAEGRLIPTGENLARFICERVQAALAHTT 129

Query: 105 AVMVK 109
           A +V+
Sbjct: 130 ARVVR 134


>UniRef50_D0MDN2 Putative uncharacterized protein n=1 Tax=Rhodothermus marinus DSM
          4252 RepID=D0MDN2_RHOM4
          Length = 156

 Score = 48.9 bits (115), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 30/87 (34%), Positives = 47/87 (54%), Gaps = 5/87 (5%)

Query: 8  KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
          K F FEAAHRLP  P    C  LHGHS+ + + + G  D   G ++DF +LK   +P  +
Sbjct: 5  KRFRFEAAHRLPWHPGA--CRHLHGHSYRLVVGLEGNPDAR-GILVDFQDLKRLVQPLID 61

Query: 68 RLDHHYL--NDIPGLENPTSEVLAKWI 92
            DH  L  +D   L++    + ++++
Sbjct: 62 TWDHATLVASDDTALQDALDALGSRYV 88


>UniRef50_Q6L053 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=Picrophilus
          torridus RepID=Q6L053_PICTO
          Length = 144

 Score = 48.9 bits (115), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 24/66 (36%), Positives = 40/66 (60%), Gaps = 6/66 (9%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH---TGWIIDFAELKAAFKPTYER 68
          + AAH +P  P   KCGRLHGH +++ + +  + +      G+ ID+ ++K A K   ER
Sbjct: 14 WSAAHIIPGHP---KCGRLHGHDYILNIRLYFDENNSLKTRGYEIDYGDIKRAAKAIIER 70

Query: 69 LDHHYL 74
          +DHH++
Sbjct: 71 MDHHFM 76


>UniRef50_B8G7W6 Putative 6-pyruvoyl tetrahydropterin synthase n=5 Tax=Bacteria
           RepID=B8G7W6_CHLAD
          Length = 130

 Score = 48.5 bits (114), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 30/94 (31%), Positives = 50/94 (53%), Gaps = 8/94 (8%)

Query: 12  FEAAHRLPHVPEGH--KCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           FEAAHRL    EG+     R+HGH++ +   +TGE     G ++D ++L+AA +     L
Sbjct: 10  FEAAHRL----EGNFGPATRMHGHTYRLEAIVTGERLQPDGTLVDMSQLQAAVQRVVADL 65

Query: 70  DHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP 101
            +  L  + GL   N T+E +A + W ++   + 
Sbjct: 66  HYRDLGTVEGLRDINTTAEHVAYYCWRRIAAALS 99


>UniRef50_UPI00016C4ECA 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Gemmata
          obscuriglobus UQM 2246 RepID=UPI00016C4ECA
          Length = 164

 Score = 48.5 bits (114), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 21/51 (41%), Positives = 30/51 (58%)

Query: 24 GHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
          GH+C RLHGH++   +E+ G + P   ++ DF  LK   K   + LDHH L
Sbjct: 27 GHQCERLHGHNYRCAVEVEGPLLPDDFYVFDFIALKKRTKEITDELDHHML 77


>UniRef50_C1A6G1 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1A6G1_GEMAT
          Length = 137

 Score = 48.5 bits (114), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 38/137 (27%), Positives = 63/137 (45%), Gaps = 16/137 (11%)

Query: 1   MMSTTLFKDFTFEAAHRL--PHVPEGH------KCGR--LHGHSFMVRLEITGEVDPHTG 50
           M   T+ +   F AAHR+  P + +        KC     HGH++ + + + G V   TG
Sbjct: 1   MPIVTVTRRLRFNAAHRVHNPALSDADNTRLFGKCNNPNWHGHNYTLDVSVRGPVAEDTG 60

Query: 51  WIIDFAELKAAF-KPTYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVV--PLLS 104
           ++ID   L+A   +    + DH   N D+P ++  NPT+E +   +W  + P +    L 
Sbjct: 61  YVIDLGALRAIVEREVLSQTDHRNFNIDVPYMQGINPTTENIVVAMWQVLGPAIAPATLQ 120

Query: 105 AVMVKETCTAGCIYRGE 121
            + + ET      Y GE
Sbjct: 121 RLRLWETENNYVDYSGE 137


>UniRef50_D1X5B9 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Streptomyces sp. ACT-1 RepID=D1X5B9_9ACTO
          Length = 234

 Score = 48.1 bits (113), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 34/97 (35%), Positives = 49/97 (50%), Gaps = 12/97 (12%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKAAFKP 64
           + K F FEA  +L         GR  GHSF     + G E+DP  G++IDF  L A  + 
Sbjct: 22  IGKQFRFEATRQL--------NGRADGHSFTAEAVLGGLELDP-VGFVIDFGRLSALKRH 72

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP 101
             +RLDH  LND   + + + E LA ++ D  +  +P
Sbjct: 73  IDDRLDHQCLNDR--VPDASDEGLAAYLTDWARTHLP 107



 Score = 40.8 bits (94), Expect = 0.013,   Method: Compositional matrix adjust.
 Identities = 30/91 (32%), Positives = 42/91 (46%), Gaps = 25/91 (27%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMV--------RLEITGEVDPHTGWIIDFAELKAAFK 63
           FEA H L  +P GH C R HGHS++V         + +  E+  H G  +D + L  +  
Sbjct: 135 FEATHHLEGLPAGHPCARRHGHSYLVSAADADGCSVPVPEELAWHIGKALDGSVLNESL- 193

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWD 94
                       DI    NPTSE LA+++ D
Sbjct: 194 ------------DI----NPTSEHLARYLSD 208


>UniRef50_O27296 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=5
          Tax=Euryarchaeota RepID=QUED_METTH
          Length = 161

 Score = 47.8 bits (112), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 26/75 (34%), Positives = 40/75 (53%), Gaps = 6/75 (8%)

Query: 9  DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
          +  F AAH    +PE   CG +HGHS++V +++ G+     G++ DF ++K   +     
Sbjct: 14 NLRFSAAHM---IPEHESCGCIHGHSYIVDVKVEGKRSGKHGFVADFKDVKDIVRRICSE 70

Query: 69 LDHHYLNDIPGLENP 83
           DH  L  IP L NP
Sbjct: 71 FDHKLL--IP-LRNP 82


>UniRef50_B3QUQ1 Putative uncharacterized protein n=1 Tax=Chloroherpeton thalassium
           ATCC 35110 RepID=B3QUQ1_CHLT3
          Length = 153

 Score = 47.8 bits (112), Expect = 1e-04,   Method: Compositional matrix adjust.
 Identities = 34/111 (30%), Positives = 56/111 (50%), Gaps = 14/111 (12%)

Query: 12  FEAAHRL--PHVPEGH------KCGRLHGHSFMVRLEIT--GEVDPHTGWIIDFAEL-KA 60
           F AAHRL  P   +        +C  ++GH     LE+T  G VD  TG++ D  +L K 
Sbjct: 23  FSAAHRLFNPEFSDAENELIYDRCNNIYGHGHNYELEVTLKGPVDKATGYVFDLKKLDKI 82

Query: 61  AFKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLSAVMV 108
             +    ++DH +LN D+  L++  P++EVL+   W+ ++  +  L    V
Sbjct: 83  LSEEILSKVDHKHLNFDVEMLKDMIPSAEVLSIVFWNAIQNRLSELGYTQV 133


>UniRef50_Q1IPI9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Acidobacteria
           RepID=Q1IPI9_ACIBL
          Length = 137

 Score = 47.0 bits (110), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 23/71 (32%), Positives = 44/71 (61%), Gaps = 4/71 (5%)

Query: 31  HGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSE 86
           HGH++ + + + G VD  TG+++D  +LK    +   + +DH YLN ++P  ++  PT+E
Sbjct: 40  HGHNYTLEVTVKGTVDATTGFVVDLKQLKEIMNREVVDAMDHRYLNHEVPEFKSQIPTTE 99

Query: 87  VLAKWIWDQVK 97
            +A  IW +++
Sbjct: 100 NIAIAIWKRLE 110


>UniRef50_Q6AKY1 Related to 6-pyruvoyl-tetrahydropterin synthase n=1
           Tax=Desulfotalea psychrophila RepID=Q6AKY1_DESPS
          Length = 80

 Score = 46.6 bits (109), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 29/72 (40%), Positives = 40/72 (55%), Gaps = 6/72 (8%)

Query: 53  IDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAV 106
           +DF  LK   K   E LDH  LN++P    +NP+SE +A +I+D + PV+      L +V
Sbjct: 3   LDFTVLKKKTKEVIELLDHRDLNNLPYFKEKNPSSEHIAIFIFDILAPVLEHKRYSLYSV 62

Query: 107 MVKETCTAGCIY 118
            V ET   GC Y
Sbjct: 63  RVMETDNQGCTY 74


>UniRef50_B2UBF2 Queuosine biosynthesis protein QueD n=85 Tax=cellular organisms
           RepID=B2UBF2_RALPJ
          Length = 158

 Score = 46.2 bits (108), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 38/124 (30%), Positives = 59/124 (47%), Gaps = 31/124 (25%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGH--KCGRLHGHSFMVRLEITGEV-----DPHTGWIIDF 55
           + ++ +   F+A HR+P    GH  +C  LHGH + + L +TGEV         G I+DF
Sbjct: 4   TVSITRRLEFDAGHRIP----GHAGQCRNLHGHRYQLELTLTGEVLHNDKAADDGMILDF 59

Query: 56  AELKA-AFKPTYERLDH------------HYLNDIPG-------LENPTSEVLAKWIWDQ 95
            ++K  A K   +  DH             +LND+ G        + PT E LA+  +D 
Sbjct: 60  GDVKQLANKHLVDLWDHAFLVYRGDTKLVEFLNDMEGGHKTVVLNDVPTVENLAQVAFDI 119

Query: 96  VKPV 99
           ++PV
Sbjct: 120 LEPV 123


>UniRef50_Q675S7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Oikopleura dioica
           RepID=Q675S7_OIKDI
          Length = 136

 Score = 46.2 bits (108), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 26/88 (29%), Positives = 49/88 (55%), Gaps = 7/88 (7%)

Query: 31  HGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLN-DIPGLEN--PTSEV 87
           HGH++ ++  I GE+   TG +++  +LK A      +LDH  ++ D+   +N   T+E 
Sbjct: 40  HGHNYTIQAVIEGEIIKETGMVMNLVDLKVAMWKVLSQLDHRNVDKDVEYFKNVPSTAEN 99

Query: 88  LAKWIWDQVKPVVPL----LSAVMVKET 111
           +A+WI+ Q+   +P     L  +++ ET
Sbjct: 100 VAQWIFIQLSQELPTGSYHLKKIILDET 127


>UniRef50_Q7UMI8 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
          RepID=Q7UMI8_RHOBA
          Length = 175

 Score = 46.2 bits (108), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 27/79 (34%), Positives = 41/79 (51%), Gaps = 8/79 (10%)

Query: 1  MMSTTLFKD-----FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDF 55
           MS T   D     F F AAH +     G  C R+HGH++ VR+ + G +D +  +++DF
Sbjct: 11 FMSATFRVDVSKEQFIFSAAHFITFA--GDICERIHGHNYGVRVSVEGPLDENR-YVVDF 67

Query: 56 AELKAAFKPTYERLDHHYL 74
            L+ A     + LDHH +
Sbjct: 68 IALRDAVLKQTQALDHHVI 86


>UniRef50_C6KTB6 6-pyruvoyltetrahydropterin synthase n=6 Tax=Plasmodium
           RepID=C6KTB6_PLAF7
          Length = 173

 Score = 45.8 bits (107), Expect = 4e-04,   Method: Compositional matrix adjust.
 Identities = 27/82 (32%), Positives = 45/82 (54%), Gaps = 8/82 (9%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           F+F  AH + +   G +   LHGH++ V L++ G V    G++IDF+ LK   K    +L
Sbjct: 23  FSFNCAHFIAY--NGFR-ETLHGHNYNVSLKVRGYVRD-DGYVIDFSILKEKVKKVCNKL 78

Query: 70  DHHYL----NDIPGLENPTSEV 87
           DHH++    +D+   EN  + +
Sbjct: 79  DHHFILPIYSDVLKFENVKNNI 100


>UniRef50_A0RWH6 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Archaea
           RepID=A0RWH6_CENSY
          Length = 270

 Score = 45.8 bits (107), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           + FTF+ AH LP V    KC  LHGH+  V +E+ G++    G ++DF + K   K    
Sbjct: 123 QSFTFDYAHVLPLVD---KCSVLHGHTSSVMVELAGQM--KDGMLVDFGKAKGIIKQAIS 177

Query: 68  RLDHHYL 74
             DH + 
Sbjct: 178 SFDHKFF 184


>UniRef50_A8G2B1 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Cyanobacteria
           RepID=A8G2B1_PROM2
          Length = 308

 Score = 45.4 bits (106), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 35/112 (31%), Positives = 55/112 (49%), Gaps = 14/112 (12%)

Query: 12  FEAAHRLPH----VPEGHK----CGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL      + E  K    C R+  HGH++ + + + G+++P TG I D   L++ 
Sbjct: 162 FNAAHRLAKDEISLSENKKIYGKCARINGHGHNYFLDVTVRGQINPRTGMICDLPSLQSI 221

Query: 62  FKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLSAVMVK 109
                 E+ DH +LN DI   +   PT E +A  I D +   +  + A + K
Sbjct: 222 IDDLIVEQFDHTFLNKDIEYFKTCVPTCENIALHISDILSSPIKNIGANLHK 273



 Score = 42.4 bits (98), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 26/83 (31%), Positives = 47/83 (56%), Gaps = 10/83 (12%)

Query: 31  HGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE-RLDHHYLNDIPGLEN------- 82
           HGH++ + + + GE+D   G +++ +++K + K     +LD  +LND+    N       
Sbjct: 53  HGHNYELIVSMGGELDS-DGMVLNLSDVKHSIKNEVTGQLDFRFLNDVWPEFNIYSQDGI 111

Query: 83  -PTSEVLAKWIWDQVKPVVPLLS 104
            PT+E L K IW+++K  +PL S
Sbjct: 112 LPTTEALVKVIWNRLKDDLPLTS 134


>UniRef50_Q604L2 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Methylococcus
           capsulatus RepID=Q604L2_METCA
          Length = 137

 Score = 45.4 bits (106), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 38/132 (28%), Positives = 60/132 (45%), Gaps = 19/132 (14%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           ++ K+  F   HRL H     KC  LHGHS    + ++       G + DFA++ AA + 
Sbjct: 3   SVTKEIFFCYGHRLMH--HSGKCRHLHGHSVRAAITVSASDLNFQGMVCDFADISAAARD 60

Query: 65  TYE-RLDHHYL--NDIPGL--------------ENPTSEVLAKWIWDQVKPVVPLLSAVM 107
             +  LDH+ L   D P L              ++PT+E LA+ I+  ++     +  V 
Sbjct: 61  FIDTHLDHNLLLHRDDPLLPLLQQAGERVLALEQHPTAEALAEMIYRDLRRKGFAVQNVT 120

Query: 108 VKETCTAGCIYR 119
           + ET +A   YR
Sbjct: 121 LWETSSACASYR 132


>UniRef50_D1CA69 Putative uncharacterized protein n=1 Tax=Sphaerobacter
          thermophilus DSM 20745 RepID=D1CA69_SPHTD
          Length = 125

 Score = 44.7 bits (104), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 28/89 (31%), Positives = 45/89 (50%), Gaps = 4/89 (4%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
          FEAAHRL    +     RLHGH++ V +E+ G      G + D   LKA        L++
Sbjct: 10 FEAAHRLR--GDFGPASRLHGHTYRVEVEVAGPQLNDDGTLFDLGLLKAWVDEAVGELNY 67

Query: 72 HYLNDIPGL--ENPTSEVLAKWIWDQVKP 98
            L+ +P     N T+E +A+++ + + P
Sbjct: 68 QNLDVLPAFAQRNSTAEEVARFLRETLAP 96


>UniRef50_Q1IPJ0 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Candidatus Koribacter
           versatilis Ellin345 RepID=Q1IPJ0_ACIBL
          Length = 135

 Score = 44.7 bits (104), Expect = 8e-04,   Method: Compositional matrix adjust.
 Identities = 33/109 (30%), Positives = 54/109 (49%), Gaps = 13/109 (11%)

Query: 2   MSTTLFKDFTFEAAHRL--PHVPEGH------KCGR--LHGHSFMVRLEITGEVDPHTGW 51
           M   L + + F A+HRL  P + E        KC     HGH++ + + + G+V P TG 
Sbjct: 1   MKAHLTRRYWFVASHRLHTPRLSEAENREVYGKCNNPFGHGHNYALEVTVGGQVAPDTGM 60

Query: 52  IIDFAEL-KAAFKPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVK 97
           + + A++ +   K   ER DH  LN +   +   PT+E L   I++ +K
Sbjct: 61  VYNLADVDRVVRKHILERYDHQNLNCLKEFQELVPTTENLCLAIFEILK 109


>UniRef50_C1ZCI0 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Planctomycetaceae
          RepID=C1ZCI0_PLALI
          Length = 161

 Score = 44.7 bits (104), Expect = 9e-04,   Method: Compositional matrix adjust.
 Identities = 29/78 (37%), Positives = 46/78 (58%), Gaps = 6/78 (7%)

Query: 10 FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
            F AAH +     G+ C RLHGH++ V +E+TG +D ++ ++ DF  L+ A +     L
Sbjct: 13 LVFSAAHFITF--NGNICERLHGHNWRVAVELTGPLDENS-YVFDFIALRDATQKLVHEL 69

Query: 70 DHHYLNDIPGLENPTSEV 87
          DH  L  +P L++PT +V
Sbjct: 70 DHKVL--LP-LQHPTIKV 84


>UniRef50_Q04S36 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Leptospira
           RepID=Q04S36_LEPBJ
          Length = 136

 Score = 43.9 bits (102), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 5/93 (5%)

Query: 12  FEAAHRL-PHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAFKPTYERL 69
           FE++H L  + P+G     +HGHS+ V L ++G  +    G   DF   K   K    +L
Sbjct: 17  FESSHFLYKYFPDGSDEP-IHGHSWKVELYLSGRKNIGEDGISFDFLTSKQRLKELVGKL 75

Query: 70  DHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV 100
           DH  +N++   +  NPTSE +A+W +  +K  V
Sbjct: 76  DHILINELEEFKKINPTSENIARWFYHYLKESV 108


>UniRef50_A2STX2 6-pyruvoyl-tetrahydropterin synthase-like protein n=5
           Tax=Methanomicrobiales RepID=A2STX2_METLZ
          Length = 135

 Score = 43.9 bits (102), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 35/111 (31%), Positives = 56/111 (50%), Gaps = 21/111 (18%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M T ++K+  F+A+HRL H  EG KC RLHGH + V + + G  D  +  ++D+  +K  
Sbjct: 1   MVTRIYKETHFDASHRLMHY-EG-KCSRLHGHRWSVEVWMDGTPDEKSRILLDYNIIKNI 58

Query: 62  FKPTYERLDHHYL--NDIPGLE-------------NPTSEVLAKWIWDQVK 97
                   DH  +   D P +E             +PTSE+LA+ I +++ 
Sbjct: 59  INV----YDHQVVLNKDDPMVEALSRFQTPVLTNGDPTSELLAEDIRERLN 105


>UniRef50_C1YMA8 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Nocardiopsis
          dassonvillei subsp. dassonvillei DSM 43111
          RepID=C1YMA8_NOCDA
          Length = 174

 Score = 43.5 bits (101), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 27/81 (33%), Positives = 41/81 (50%), Gaps = 6/81 (7%)

Query: 11 TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE-RL 69
           FE AHRLPH+    KC  LHGHS+   + ++       G +++F   K A +   +  L
Sbjct: 10 NFETAHRLPHLSG--KCMNLHGHSWWAEVSVSAPALSEDGTVVEFGAFKKALRAFVDTHL 67

Query: 70 DHHYLNDIPGLENPTSEVLAK 90
          DH     + G  +P + VLA+
Sbjct: 68 DH---GAMLGAGDPLAAVLAE 85


>UniRef50_Q5KZY1 6-pyruvoyltetrahydropterin synthase(PTP synthase) n=7 Tax=Bacteria
           RepID=Q5KZY1_GEOKA
          Length = 134

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 33/118 (27%), Positives = 57/118 (48%), Gaps = 14/118 (11%)

Query: 8   KDFTFEAAHRLPHVPEGH--------KCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAE 57
           + + F +AHRL      +        KC     HGH++ + + + G+ DP TG +++ AE
Sbjct: 3   RRYYFSSAHRLHSDQLTNEENQRLFGKCNNRYGHGHNYCLEVTVIGKPDPITGMVVNLAE 62

Query: 58  L-KAAFKPTYERLDHHYLN---DIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKET 111
           L +   +    + DH +LN   D     NPT+E +   IW+ + P +  L  + + ET
Sbjct: 63  LDEIVNREVLVKFDHKHLNLDTDEFKQINPTAENIVIVIWELLAPHLSSLYKIGLWET 120


>UniRef50_Q4LA59 Similar to 6-pyruvoyl tetrahydropterin synthase n=1
           Tax=Staphylococcus haemolyticus JCSC1435
           RepID=Q4LA59_STAHJ
          Length = 143

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 30/117 (25%), Positives = 59/117 (50%), Gaps = 7/117 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
           T L + + F+  +R+    +  +   LH HS+ + +++   +  + G  +DF E+ A + 
Sbjct: 21  TVLKQQYDFKCDNRIYFSEDIFR--DLHNHSYRLYVDVLSPIGDY-GLGLDFNEVDAIYN 77

Query: 64  PTYE-RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP---LLSAVMVKETCTAGC 116
              E +L+H  +N+     N T+E +A WIWD+ +  +P    + A+ + ET   G 
Sbjct: 78  KVIEPKLNHQLINETLPDMNTTAENIAMWIWDEFEQHLPGEHCMYALQLFETDRHGV 134


>UniRef50_C1VD01 PreQ(0) biosynthesis protein QueD n=1 Tax=Halogeometricum
           borinquense DSM 11551 RepID=C1VD01_9EURY
          Length = 160

 Score = 43.1 bits (100), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 37/124 (29%), Positives = 58/124 (46%), Gaps = 30/124 (24%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE------------ 57
               A HRL H     KC R HGH++ + +E+TG++    GWI+D  E            
Sbjct: 38  IRISAGHRLMH--HDGKCSRPHGHNYEISVEVTGQL-TDEGWIVDKGEVTTVIDEWDHRF 94

Query: 58  -------LKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP---LLSAVM 107
                  L +AF+ + +  D   + D P    PT+EV+A  + D+++  +P      AV 
Sbjct: 95  LVETGDPLVSAFEASGD-ADSLVVLDAP----PTAEVMAVLLEDKLRARLPDSVSDVAVE 149

Query: 108 VKET 111
           V+ET
Sbjct: 150 VRET 153


>UniRef50_A9M1Z1 6-pyruvoyl tetrahydrobiopterin synthase, putative n=26
          Tax=Neisseria RepID=A9M1Z1_NEIM0
          Length = 140

 Score = 42.7 bits (99), Expect = 0.003,   Method: Compositional matrix adjust.
 Identities = 33/95 (34%), Positives = 51/95 (53%), Gaps = 15/95 (15%)

Query: 6  LFKDFTFEAAHRLPHVPEGH--KCGRLHGHSFMVRLEITGEVD-----PHTGWIIDFAEL 58
          + K FTF+++H L    +GH  KC  LHGH++  +LEIT   D     P  G ++DF +L
Sbjct: 3  ITKIFTFDSSHML----DGHDGKCQNLHGHTY--KLEITVSDDPVRGGPKDGMVMDFTDL 56

Query: 59 KAAFKP-TYERLDHHYL-NDIPGLENPTSEVLAKW 91
          KA  K    +  DH ++ +   G E+  + +L  W
Sbjct: 57 KAIVKQHITDPFDHAFIYHGGNGRESQIAALLEGW 91


>UniRef50_A4FWS8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Methanococcus
          RepID=A4FWS8_METM5
          Length = 167

 Score = 42.7 bits (99), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 1/57 (1%)

Query: 19 PHVPEGH-KCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
           H+  GH  CG +HGHS+ V ++++GE     G++ DF  LK   K     LDH  L
Sbjct: 17 AHIVFGHDSCGVIHGHSYYVDVKLSGEPSGEFGFVCDFKILKQIVKELCGELDHKLL 73


>UniRef50_A2BJ89 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Hyperthermus butylicus
           DSM 5456 RepID=A2BJ89_HYPBU
          Length = 126

 Score = 42.4 bits (98), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 31/98 (31%), Positives = 48/98 (48%), Gaps = 16/98 (16%)

Query: 12  FEAAHRLPHVPEGH-KCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERL 69
           F AAHR+    EGH +CG++HGH++ V + +  E        +D   L+    +  ++R 
Sbjct: 10  FSAAHRI----EGHPRCGKIHGHNYRVCIVVREE----RPLQVDLDALEEWLERNVFQRF 61

Query: 70  DHHYLNDIPGLENP------TSEVLAKWIWDQVKPVVP 101
           DH YLN +    +       TSE LA  I D ++   P
Sbjct: 62  DHQYLNKVLAAPDKDEKLVVTSEELAVLIADMLEQAFP 99


>UniRef50_B2HZD9 6-pyruvoyl-tetrahydropterin synthase n=31 Tax=Proteobacteria
           RepID=B2HZD9_ACIBC
          Length = 198

 Score = 42.0 bits (97), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 30/104 (28%), Positives = 43/104 (41%), Gaps = 5/104 (4%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGR-LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           K F FE AH + +     +C R +HGHS+ V L +      H   + DF  LK   K  +
Sbjct: 5   KLFKFENAHVVRNCT-SDRCKRSIHGHSYKVELLLKASKLDHGQMVYDFGLLKGVIKDLF 63

Query: 67  ERLDH---HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVM 107
           +  DH    +  D P   +      A+WI   V P     S + 
Sbjct: 64  DSFDHAICFWEKDDPQYIDACKTFSARWISLPVSPSAEQFSRIF 107


>UniRef50_Q1NNT9 Putative uncharacterized protein n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NNT9_9DELT
          Length = 154

 Score = 41.6 bits (96), Expect = 0.007,   Method: Compositional matrix adjust.
 Identities = 31/99 (31%), Positives = 50/99 (50%), Gaps = 7/99 (7%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKAAFK 63
           TL  + +F A HRL     G +    H H + + + + G E++ H G+++D  EL     
Sbjct: 29  TLGVNRSFSARHRLIGGDWGEES-ITHAHCYRLEVALDGPELNEH-GFLVDIVELAGNLD 86

Query: 64  PTYERLDHHYLNDIP---GLENPTSEVLAKWIWDQVKPV 99
              E  +   LND+P   GL NP+ E LA+ IW ++  +
Sbjct: 87  LVQEAYEDRILNDLPEFAGL-NPSIENLARLIWQRLSQL 124


>UniRef50_B8HQA0 Putative uncharacterized protein n=1 Tax=Cyanothece sp. PCC 7425
          RepID=B8HQA0_CYAP4
          Length = 146

 Score = 41.6 bits (96), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 23/60 (38%), Positives = 32/60 (53%), Gaps = 1/60 (1%)

Query: 13 EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE-RLDH 71
          EAAHR        KC  +HGHS+ V L +  E     G +I+F +LK A++   +  LDH
Sbjct: 11 EAAHRFFQADNSLKCRSIHGHSWSVILTLKAEKLDAQGMVIEFGQLKTAWRSWLDAHLDH 70


>UniRef50_D2QJ42 Putative uncharacterized protein n=1 Tax=Spirosoma linguale DSM 74
           RepID=D2QJ42_9SPHI
          Length = 143

 Score = 41.2 bits (95), Expect = 0.009,   Method: Compositional matrix adjust.
 Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 16/108 (14%)

Query: 5   TLFKDFTFEAAHRLPH---VPEGH-----KCGR--LHGHSFMVRLEITGEVDPHTGWIID 54
            +F+   F AAHRL +     E +     KC     HGH++ + +++ G +D  TG++ID
Sbjct: 12  AVFRKEHFNAAHRLNNPNWSDEKNTRVYGKCNNPNYHGHNYELIVQVIGPIDDETGYVID 71

Query: 55  FAELKAAFKP-TYERLDHHYLN----DIPGLENPTSEVLAKWIWDQVK 97
              L    K    +R DH  LN    +   L NP++E +A  I++ ++
Sbjct: 72  MKLLSDLIKEHVTDRFDHKNLNLDTEEFADL-NPSAENIAIVIYNILR 118


>UniRef50_D0MWX1 Putative uncharacterized protein n=2 Tax=Phytophthora infestans
           T30-4 RepID=D0MWX1_PHYIN
          Length = 244

 Score = 41.2 bits (95), Expect = 0.011,   Method: Compositional matrix adjust.
 Identities = 23/68 (33%), Positives = 42/68 (61%), Gaps = 5/68 (7%)

Query: 8   KDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           KD+  F AAH + +  +G +  +LHGH++ + + ITG+V P  G+++DF E+K   +   
Sbjct: 89  KDYMKFNAAHFIAY--KGFR-EKLHGHNYRLAVTITGQVGPD-GYVVDFGEIKKISRVIC 144

Query: 67  ERLDHHYL 74
           + L+  +L
Sbjct: 145 KDLNESFL 152


>UniRef50_C3KVW1 Queuosine biosynthesis protein QueD n=22 Tax=Bacteria
          RepID=C3KVW1_CLOB6
          Length = 143

 Score = 40.8 bits (94), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 25/68 (36%), Positives = 38/68 (55%), Gaps = 12/68 (17%)

Query: 11 TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT-------GEVDPHTGWIIDFAELKAAFK 63
          +F++AH L    EG KCG +HGH + V++++        G++D   G IIDF +LK   K
Sbjct: 9  SFDSAHFLAGY-EG-KCGNIHGHRWKVKIQVQAESLVQGGQLD---GMIIDFGDLKKDVK 63

Query: 64 PTYERLDH 71
             +  DH
Sbjct: 64 SMVDYYDH 71


>UniRef50_Q0KAE6 6-Pyruvoyl tetrahydrobiopterin synthase protein n=5
           Tax=Burkholderiaceae RepID=Q0KAE6_RALEH
          Length = 158

 Score = 40.8 bits (94), Expect = 0.014,   Method: Compositional matrix adjust.
 Identities = 32/121 (26%), Positives = 56/121 (46%), Gaps = 26/121 (21%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV-----DPHTGWIIDFAE 57
             ++ +   F++ HR+P+     +C  +HGH + + L ++GEV         G I+DF +
Sbjct: 4   QVSITRRLEFDSGHRIPN--HCGQCRNIHGHRYRLDLTLSGEVLHREGASDDGMILDFGD 61

Query: 58  LKA-AFKPTYERLDHHY---------LNDIPGLEN---------PTSEVLAKWIWDQVKP 98
           +KA A +    + DH +         LN +  +E          PT E LA+  +D + P
Sbjct: 62  IKALANEHLVNKWDHAFLIYRGDTALLNFLQSMEGHKTVVLDAIPTVENLAQVAFDILAP 121

Query: 99  V 99
           V
Sbjct: 122 V 122


>UniRef50_Q9HHN6 Vng6306c n=3 Tax=Halobacteriaceae RepID=Q9HHN6_HALSA
          Length = 150

 Score = 39.7 bits (91), Expect = 0.028,   Method: Compositional matrix adjust.
 Identities = 22/63 (34%), Positives = 31/63 (49%), Gaps = 7/63 (11%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
            A HRL H     KC R HGH++ + +EITG++    GW++D    K          DH
Sbjct: 29 ISAGHRLQH--HDGKCSRPHGHNYEISVEITGQLTDE-GWVVD----KGTVTAVVSDWDH 81

Query: 72 HYL 74
           +L
Sbjct: 82 RFL 84


>UniRef50_O59602 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=9
          Tax=Thermococcaceae RepID=QUED_PYRHO
          Length = 157

 Score = 39.7 bits (91), Expect = 0.029,   Method: Compositional matrix adjust.
 Identities = 23/58 (39%), Positives = 32/58 (55%), Gaps = 2/58 (3%)

Query: 12 FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
          F+++H L    E  KC R+HGH++ V +EI GE++   G I DF  L    K    RL
Sbjct: 17 FDSSHFLELEYES-KCKRIHGHTYKVEVEIEGELNEE-GMIFDFTHLSEIVKELDHRL 72


>UniRef50_C1ZE85 PreQ(0) biosynthesis protein QueD n=2 Tax=Planctomycetaceae
           RepID=C1ZE85_PLALI
          Length = 136

 Score = 39.7 bits (91), Expect = 0.032,   Method: Compositional matrix adjust.
 Identities = 38/130 (29%), Positives = 55/130 (42%), Gaps = 23/130 (17%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP-TYE 67
           +  F   HRL  +    KC  LHGH+    + + GE     G ++DF +LK        +
Sbjct: 7   EIQFCYGHRL--LNYSGKCRHLHGHNGKAIITLAGESLDERGMLVDFGDLKRTVSQWIDD 64

Query: 68  RLDHHY-----------LND-------IPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
            LDH             L D       IP  ENPT+E +AK I+++   V   +  V + 
Sbjct: 65  HLDHRMVLCERDPMVKILRDAGEPLYLIP--ENPTAENIAKLIYEKTVEVGLPVIQVGLW 122

Query: 110 ETCTAGCIYR 119
           ET     +YR
Sbjct: 123 ETAKNYAVYR 132


>UniRef50_B2KCS0 Putative uncharacterized protein n=1 Tax=Elusimicrobium minutum
           Pei191 RepID=B2KCS0_ELUMP
          Length = 120

 Score = 39.3 bits (90), Expect = 0.037,   Method: Compositional matrix adjust.
 Identities = 36/118 (30%), Positives = 56/118 (47%), Gaps = 9/118 (7%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           L K  +F AAH      EG      H H+F   +++ G  + + G++ DF  ++      
Sbjct: 8   LIKKSSFTAAHS----HEGMLNEAQHTHTFHYEIKLCGFTN-NEGFLTDFRIVEEDMNTL 62

Query: 66  YER-LDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV-PLLSAVMVKETCTAGCIYRGE 121
             + L    LN    L++PT+E LA WI+ ++K     +L  V V ET  +  IY GE
Sbjct: 63  INKELKDKNLNIF--LKDPTTEKLAVWIFRRLKDSYGKMLHCVTVYETPQSAVIYEGE 118


>UniRef50_UPI0001B4C1FC hypothetical protein ShygA5_47370 n=1 Tax=Streptomyces
           hygroscopicus ATCC 53653 RepID=UPI0001B4C1FC
          Length = 174

 Score = 38.9 bits (89), Expect = 0.048,   Method: Compositional matrix adjust.
 Identities = 29/97 (29%), Positives = 46/97 (47%), Gaps = 20/97 (20%)

Query: 24  GHKCGRLHGHSFMVRLEI-TGEVDPHTGWIIDFAELK-------AAFKPT---------- 65
           G KC  LHG+     +E   GE++P TG++IDF +LK       A F  T          
Sbjct: 44  GGKCSFLHGYERSFEIEFGCGELEPKTGFVIDFGDLKEVRALLQAQFDHTTLIAADDPHR 103

Query: 66  --YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV 100
             +E L    + D+  +++   E  A+W+ D+V  +V
Sbjct: 104 ELFEDLGRSGVIDLRIMDHTGMEGAAEWVHDRVAQLV 140


>UniRef50_Q4JIS7 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=uncultured
          bacterium BAC10-4 RepID=Q4JIS7_9BACT
          Length = 162

 Score = 38.9 bits (89), Expect = 0.053,   Method: Compositional matrix adjust.
 Identities = 20/58 (34%), Positives = 34/58 (58%), Gaps = 4/58 (6%)

Query: 27 CGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLENPT 84
          C  LHGH++  R+E+ G++D +  ++ DF  LK   +   + +DH  L  +P L+NP 
Sbjct: 27 CETLHGHNYRARVELEGDLDENY-YVWDFVSLKRLMRRLVDEMDHRML--LP-LQNPA 80


>UniRef50_B6KR79 Putative uncharacterized protein n=3 Tax=Toxoplasma gondii
           RepID=B6KR79_TOXGO
          Length = 475

 Score = 38.5 bits (88), Expect = 0.068,   Method: Composition-based stats.
 Identities = 18/46 (39%), Positives = 29/46 (63%), Gaps = 1/46 (2%)

Query: 29  RLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
           RLHGH++ V ++I G V P  G+I+DF ++K   +   + LD H +
Sbjct: 341 RLHGHNYSVTVKIGGIVGP-DGYILDFGDIKQTAREVCKSLDEHLI 385


>UniRef50_Q18HJ5 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n=3 Tax=cellular
           organisms RepID=Q18HJ5_HALWD
          Length = 134

 Score = 38.5 bits (88), Expect = 0.070,   Method: Compositional matrix adjust.
 Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 2/71 (2%)

Query: 28  GRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLE--NPTS 85
           G++H H F V L   G+     G++++   +++  +   ER     LND+P  E  NP+ 
Sbjct: 31  GQIHSHHFEVELHFAGDSLGEYGYLLNIVTVESILEDLVERYRDSVLNDLPEFEGLNPSV 90

Query: 86  EVLAKWIWDQV 96
           E  ++   D V
Sbjct: 91  ENFSRIFGDHV 101


>UniRef50_UPI0001C378A0 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Ruminococcus
           flavefaciens FD-1 RepID=UPI0001C378A0
          Length = 165

 Score = 38.1 bits (87), Expect = 0.087,   Method: Compositional matrix adjust.
 Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 6/78 (7%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG----EVDPHTGWIIDFAELKAAFKPTY 66
           +F++AH L       KC  +HGH + V + I G    +     G +IDF++LK A     
Sbjct: 35  SFDSAHFLAGYQG--KCANIHGHRWKVEVSICGGSLQQEGTKRGMLIDFSDLKKAVHDMA 92

Query: 67  ERLDHHYLNDIPGLENPT 84
           +  DH  + +   L+  T
Sbjct: 93  DSFDHALIYETGSLKETT 110


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_P65871 6-carboxy-5,6,7,8-tetrahydropterin synthase n=10...   202   2e-51
UniRef50_A0PNB2 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   179   3e-44
UniRef50_A6EFM8 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   178   4e-44
UniRef50_B2IGN7 Queuosine biosynthesis protein QueD n=4 Tax=Rhiz...   174   9e-43
UniRef50_Q8K9D8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=21...   173   1e-42
UniRef50_B3DVJ6 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bac...   167   1e-40
UniRef50_Q6MLY9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdel...   160   1e-38
UniRef50_C5SC00 Putative uncharacterized protein n=1 Tax=Allochr...   157   8e-38
UniRef50_UPI0001C165E4 Dihydropteroate synthase n=1 Tax=Raphidio...   154   5e-37
UniRef50_C6QGG4 Queuosine biosynthesis protein QueD n=1 Tax=Hyph...   149   2e-35
UniRef50_C6QCT4 Putative uncharacterized protein n=1 Tax=Hyphomi...   147   7e-35
UniRef50_A4XG23 Putative uncharacterized protein n=4 Tax=Bacteri...   146   2e-34
UniRef50_B7K1S3 Queuosine biosynthesis protein QueD n=6 Tax=Cyan...   146   2e-34
UniRef50_B6CWI6 ToyB n=5 Tax=Bacteria RepID=B6CWI6_STRRM              145   3e-34
UniRef50_C9RBW1 Putative uncharacterized protein n=1 Tax=Ammonif...   144   1e-33
UniRef50_Q2IJB0 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Ana...   143   2e-33
UniRef50_C9KKI2 Queuosine biosynthesis protein QueD n=2 Tax=Veil...   141   6e-33
UniRef50_B5YCT3 6-pyruvoyl-tetrahydropterin synthase n=24 Tax=Ba...   140   1e-32
UniRef50_Q1NNH1 Putative uncharacterized protein n=2 Tax=delta p...   140   1e-32
UniRef50_Q2K3W9 6-pyruvoyl tetrahydropterin synthase protein n=1...   140   1e-32
UniRef50_D0B3L9 6-pyruvoyl tetrahydrobiopterin synthase n=47 Tax...   140   1e-32
UniRef50_C9LTT9 Queuosine biosynthesis protein QueD n=3 Tax=Bact...   140   1e-32
UniRef50_Q55798 6-carboxy-5,6,7,8-tetrahydropterin synthase n=7 ...   139   2e-32
UniRef50_Q3ADI6 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   139   3e-32
UniRef50_A7HXX3 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Par...   138   5e-32
UniRef50_Q2IKV5 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Ana...   138   6e-32
UniRef50_B9K796 Queuosine biosynthesis protein QueD n=2 Tax=Bact...   137   8e-32
UniRef50_B5JVD7 Probable 6-pyruvoyltetrahydrobiopterin synthase ...   137   1e-31
UniRef50_B9ZMJ4 Queuosine biosynthesis protein QueD n=1 Tax=Thio...   137   1e-31
UniRef50_B5YJJ7 6-pyruvoyl-tetrahydropterin synthase n=4 Tax=Bac...   137   1e-31
UniRef50_Q0BPQ0 Queuosine biosynthesis protein queD n=2 Tax=Prot...   136   2e-31
UniRef50_Q2LVK6 Queuosine biosynthesis protein n=1 Tax=Syntrophu...   136   2e-31
UniRef50_Q03393 6-pyruvoyl tetrahydrobiopterin synthase n=19 Tax...   136   2e-31
UniRef50_Q0RM63 6-pyruvoyl tetrahydrobiopterin synthase n=11 Tax...   135   3e-31
UniRef50_B9Z1F8 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Nei...   135   4e-31
UniRef50_Q1IHK8 Putative uncharacterized protein n=3 Tax=Acidoba...   134   6e-31
UniRef50_A1WW30 Putative uncharacterized protein n=1 Tax=Halorho...   134   1e-30
UniRef50_Q7NSB8 Probable 6-pyruvoyltetrahydrobiopterin synthase ...   132   3e-30
UniRef50_A8L9C2 Putative uncharacterized protein n=1 Tax=Frankia...   132   3e-30
UniRef50_C8R1L5 Putative uncharacterized protein n=1 Tax=Desulfu...   132   4e-30
UniRef50_Q31FT9 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...   132   5e-30
UniRef50_C4V0R8 Possible 6-pyruvoyltetrahydropterin synthase n=1...   131   6e-30
UniRef50_C1SPF1 PreQ(0) biosynthesis protein QueD n=1 Tax=Denitr...   130   9e-30
UniRef50_Q3SPB8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Alp...   130   1e-29
UniRef50_B0VJG6 6-pyruvoyl tetrahydrobiopterin synthase family p...   130   1e-29
UniRef50_A5D2E2 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Pep...   130   2e-29
UniRef50_B4RHW0 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...   130   2e-29
UniRef50_C0GP47 Queuosine biosynthesis protein QueD n=1 Tax=Desu...   129   3e-29
UniRef50_B5Y6S0 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Bac...   129   4e-29
UniRef50_A9AWJ6 Putative uncharacterized protein n=1 Tax=Herpeto...   128   5e-29
UniRef50_Q90W95 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...   127   1e-28
UniRef50_D0J5V8 6-pyruvoyl tetrahydropterin synthase and n=7 Tax...   126   2e-28
UniRef50_C1TQH0 PreQ(0) biosynthesis protein QueD n=2 Tax=Bacter...   126   2e-28
UniRef50_C8VWH9 Putative uncharacterized protein n=1 Tax=Desulfo...   126   2e-28
UniRef50_A1HNF1 Putative uncharacterized protein n=1 Tax=Thermos...   126   2e-28
UniRef50_B5W8I5 Putative uncharacterized protein n=3 Tax=Cyanoba...   126   3e-28
UniRef50_B0TFF5 6-pyruvoyl-tetrahydropterin synthase, putative n...   125   3e-28
UniRef50_A3UD70 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   125   3e-28
UniRef50_Q3ZW85 6-pyruvoyl tetrahydrobiopterin synthase n=5 Tax=...   125   4e-28
UniRef50_B8FMW4 Queuosine biosynthesis protein QueD n=3 Tax=Prot...   124   6e-28
UniRef50_P48611 6-pyruvoyl tetrahydrobiopterin synthase n=16 Tax...   124   8e-28
UniRef50_A0M3Y1 Conserved tetrahydrobiopterin biosynthesis-like ...   124   9e-28
UniRef50_Q3A420 6-pyruvoyl-tetrahydropterin synthase n=7 Tax=Bac...   124   1e-27
UniRef50_A6LBJ5 6-pyruvoyl-tetrahydropterin synthase n=43 Tax=Ba...   124   1e-27
UniRef50_D2L9S0 Putative uncharacterized protein n=1 Tax=Desulfo...   124   1e-27
UniRef50_A2SD50 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   124   1e-27
UniRef50_C0QLV0 PtpS n=8 Tax=cellular organisms RepID=C0QLV0_DESAH    124   1e-27
UniRef50_B8J0W0 Queuosine biosynthesis protein QueD n=8 Tax=Desu...   123   2e-27
UniRef50_C1A6G1 6-pyruvoyl tetrahydropterin synthase family prot...   123   2e-27
UniRef50_B1ZTR4 Putative uncharacterized protein n=3 Tax=Bacteri...   123   2e-27
UniRef50_B9EM09 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=...   123   2e-27
UniRef50_D1B660 Putative uncharacterized protein n=1 Tax=Therman...   123   2e-27
UniRef50_Q8Z0L1 Alr0080 protein n=5 Tax=Cyanobacteria RepID=Q8Z0...   122   4e-27
UniRef50_B1GYR9 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   122   5e-27
UniRef50_Q6ARY1 Related to 6-pyruvoyl tetrahydropterin synthase ...   122   5e-27
UniRef50_C7HJ58 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Clo...   122   5e-27
UniRef50_B8DNN3 Putative uncharacterized protein n=3 Tax=Desulfo...   121   5e-27
UniRef50_C7QN33 6-pyruvoyltetrahydropterin synthase n=3 Tax=Cyan...   121   5e-27
UniRef50_B0SX52 Queuosine biosynthesis protein QueD n=1 Tax=Caul...   121   6e-27
UniRef50_Q1ZXI0 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   121   6e-27
UniRef50_D0Y1P4 6-pyruvoyl tetrahydropterin synthase n=3 Tax=cel...   121   8e-27
UniRef50_C6VZC4 Putative uncharacterized protein n=3 Tax=Sphingo...   120   1e-26
UniRef50_Q6B324 6-pyruvoyl tetrahydropterin synthase (Fragment) ...   120   2e-26
UniRef50_A2BZT2 6-pyruvoyl tetrahydropterin synthase n=48 Tax=ce...   118   4e-26
UniRef50_Q30ZA2 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   118   5e-26
UniRef50_Q3J9J8 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Chr...   118   6e-26
UniRef50_C1DVU3 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=...   117   8e-26
UniRef50_O31676 6-carboxy-5,6,7,8-tetrahydropterin synthase n=85...   117   1e-25
UniRef50_C0N3T5 6-pyruvoyl tetrahydropterin synthase superfamily...   117   1e-25
UniRef50_Q3B4V1 6-pyruvoyltetrahydropterin synthase n=11 Tax=Chl...   116   3e-25
UniRef50_D1NB55 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Vic...   115   3e-25
UniRef50_O02058 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   115   5e-25
UniRef50_B2KC64 Putative uncharacterized protein n=1 Tax=Elusimi...   114   7e-25
UniRef50_Q63E30 6-pyruvoyl tetrahydrobiopterin synthase n=100 Ta...   114   7e-25
UniRef50_C1CXM4 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   114   7e-25
UniRef50_A0B6A5 Putative uncharacterized protein n=1 Tax=Methano...   114   1e-24
UniRef50_O66626 6-carboxy-5,6,7,8-tetrahydropterin synthase n=8 ...   113   2e-24
UniRef50_O29809 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...   113   2e-24
UniRef50_A8G2B1 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Cya...   112   3e-24
UniRef50_C4XPJ5 6-pyruvoyl tetrahydropterin synthase family prot...   111   6e-24
UniRef50_A6GQ16 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   111   6e-24
UniRef50_A3EQ19 Probable 6-pyruvoyl tetrahydrobiopterin synthase...   111   8e-24
UniRef50_Q46G73 6-pyruvoyltetrahydropterin synthase n=7 Tax=Eury...   111   9e-24
UniRef50_A1SFN0 Putative uncharacterized protein n=1 Tax=Nocardi...   110   9e-24
UniRef50_A8Y1U6 C. briggsae CBR-PTPS-1 protein n=2 Tax=Caenorhab...   110   1e-23
UniRef50_C5A6K8 6-pyruvoyl tetrahydrobiopterin synthase (PtpS) n...   110   1e-23
UniRef50_UPI0001C1695B hypothetical protein CRD_00116 n=2 Tax=No...   109   3e-23
UniRef50_P44123 6-carboxy-5,6,7,8-tetrahydropterin synthase n=31...   109   3e-23
UniRef50_Q1IPI9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Aci...   109   4e-23
UniRef50_D1CA69 Putative uncharacterized protein n=1 Tax=Sphaero...   108   6e-23
UniRef50_UPI0001C418E1 queuosine biosynthesis protein QueD n=1 T...   107   8e-23
UniRef50_B3T9P1 Putative 6-pyruvoyl tetrahydropterin synthase n=...   106   2e-22
UniRef50_A3VUJ4 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...   106   2e-22
UniRef50_A3ZTI8 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   105   4e-22
UniRef50_D2ML00 Putative uncharacterized protein (Fragment) n=1 ...   105   4e-22
UniRef50_Q2PY17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bac...   104   8e-22
UniRef50_D1JB18 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   104   8e-22
UniRef50_Q1IPJ0 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Can...   104   1e-21
UniRef50_B3QUQ1 Putative uncharacterized protein n=1 Tax=Chloroh...   104   1e-21
UniRef50_Q675S7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...   103   2e-21
UniRef50_A0L5B3 Putative uncharacterized protein n=1 Tax=Magneto...   103   2e-21
UniRef50_B8G7W6 Putative 6-pyruvoyl tetrahydropterin synthase n=...   102   3e-21
UniRef50_Q604L2 Putative 6-pyruvoyl tetrahydropterin synthase n=...   101   9e-21
UniRef50_Q7UGM2 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...   100   1e-20
UniRef50_Q04S36 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Lep...   100   2e-20
UniRef50_C1AB96 6-pyruvoyl tetrahydropterin synthase family prot...    98   8e-20
UniRef50_D0MDN2 Putative uncharacterized protein n=1 Tax=Rhodoth...    98   9e-20
UniRef50_A7BS03 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Beg...    98   9e-20
UniRef50_UPI0001B56D65 putative 6-pyruvoyl tetrahydropterin synt...    97   1e-19
UniRef50_B2UBF2 Queuosine biosynthesis protein QueD n=85 Tax=cel...    95   7e-19
UniRef50_UPI0001B56179 putative 6-pyruvoyl tetrahydropterin synt...    94   1e-18
UniRef50_A2STX2 6-pyruvoyl-tetrahydropterin synthase-like protei...    93   2e-18
UniRef50_UPI00016C4ECA 6-pyruvoyl tetrahydrobiopterin synthase n...    92   5e-18
UniRef50_UPI000038E306 6-pyruvoyltetrahydrobiopterin synthase n=...    91   1e-17
UniRef50_Q979P1 Putative uncharacterized protein TVG1150731 n=2 ...    90   2e-17
UniRef50_Q8TX57 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Met...    84   1e-15
UniRef50_C1YMA8 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Noc...    84   2e-15
UniRef50_O27296 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    83   2e-15
UniRef50_Q6AKY1 Related to 6-pyruvoyl-tetrahydropterin synthase ...    82   6e-15
UniRef50_D1X5B9 6-pyruvoyl-tetrahydropterin synthase-like protei...    82   6e-15
UniRef50_Q7UMI8 Putative uncharacterized protein n=2 Tax=Plancto...    77   2e-13
UniRef50_C1ZCI0 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Pla...    77   2e-13
UniRef50_B5I9Q5 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...    72   7e-12
UniRef50_Q6L053 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=P...    70   1e-11
UniRef50_A0RWH6 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Arc...    70   3e-11
UniRef50_C6KTB6 6-pyruvoyltetrahydropterin synthase n=6 Tax=Plas...    68   9e-11

Sequences not found previously or not previously below threshold:

UniRef50_Q5KZY1 6-pyruvoyltetrahydropterin synthase(PTP synthase...   113   2e-24
UniRef50_D2QJ42 Putative uncharacterized protein n=1 Tax=Spiroso...   112   5e-24
UniRef50_A9M1Z1 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   109   3e-23
UniRef50_C1ZE85 PreQ(0) biosynthesis protein QueD n=2 Tax=Planct...   105   3e-22
UniRef50_D2R401 Putative uncharacterized protein n=1 Tax=Pirellu...   103   2e-21
UniRef50_UPI0001C378A0 6-pyruvoyl tetrahydrobiopterin synthase n...   102   3e-21
UniRef50_A0Q1F5 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   100   1e-20
UniRef50_C3KVW1 Queuosine biosynthesis protein QueD n=22 Tax=Bac...   100   1e-20
UniRef50_A6LWG4 6-pyruvoyl tetrahydrobiopterin synthase, putativ...    99   4e-20
UniRef50_C2D910 Possible 6-pyruvoyltetrahydropterin synthase n=1...    98   6e-20
UniRef50_C5RIU8 Putative 6-pyruvoyl tetrahydropterin synthase n=...    97   2e-19
UniRef50_B4D1V3 6-pyruvoyl-tetrahydropterin synthase-like protei...    93   2e-18
UniRef50_A4CIF9 6-pyruvoyl tetrahydropterin synthase n=19 Tax=Ba...    92   4e-18
UniRef50_Q0KAE6 6-Pyruvoyl tetrahydrobiopterin synthase protein ...    91   1e-17
UniRef50_C7IE00 Putative uncharacterized protein n=1 Tax=Clostri...    91   2e-17
UniRef50_Q0AAF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Pro...    89   3e-17
UniRef50_Q3B2Y4 6-pyruvoyl tetrahydrobiopterin synthase, putativ...    89   5e-17
UniRef50_Q3ATI1 6-pyruvoyl tetrahydrobiopterin synthase, putativ...    88   1e-16
UniRef50_A1ZSU4 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=...    87   1e-16
UniRef50_C1VD01 PreQ(0) biosynthesis protein QueD n=1 Tax=Haloge...    87   2e-16
UniRef50_Q028J7 Putative uncharacterized protein n=1 Tax=Candida...    87   2e-16
UniRef50_C7MN71 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Cor...    86   4e-16
UniRef50_Q92J44 6-carboxy-5,6,7,8-tetrahydropterin synthase n=11...    84   2e-15
UniRef50_Q1NNT9 Putative uncharacterized protein n=2 Tax=delta p...    83   2e-15
UniRef50_C6MFP0 Queuosine biosynthesis protein QueD n=1 Tax=Nitr...    83   2e-15
UniRef50_A9B2M7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...    83   3e-15
UniRef50_B8HQA0 Putative uncharacterized protein n=1 Tax=Cyanoth...    82   4e-15
UniRef50_B2UPS6 6-pyruvoyl-tetrahydropterin synthase-like protei...    82   4e-15
UniRef50_Q1RHI6 6-carboxy-5,6,7,8-tetrahydropterin synthase n=4 ...    82   6e-15
UniRef50_O59602 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    82   6e-15
UniRef50_C0BIT7 6-pyruvoyl tetrahydropterin synthase n=6 Tax=Bac...    82   6e-15
UniRef50_D1R7R7 Putative uncharacterized protein n=2 Tax=Parachl...    81   1e-14
UniRef50_A9GTQ5 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sora...    80   2e-14
UniRef50_A2BJ89 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Hyp...    79   4e-14
UniRef50_Q9HHN6 Vng6306c n=3 Tax=Halobacteriaceae RepID=Q9HHN6_H...    78   1e-13
UniRef50_A1VXP3 6-pyruvoyl tetrahydrobiopterin synthase, homolog...    77   2e-13
UniRef50_Q1IAJ5 Putative 6-pyruvoyl-tetrahydropterin synthase-li...    77   2e-13
UniRef50_Q4JA84 Conserved Archaeal protein n=12 Tax=Sulfolobacea...    76   3e-13
UniRef50_B2KCS0 Putative uncharacterized protein n=1 Tax=Elusimi...    76   4e-13
UniRef50_C3JCW3 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=...    75   6e-13
UniRef50_A4FWS8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Met...    75   7e-13
UniRef50_Q2RTB4 Putative uncharacterized protein n=1 Tax=Rhodosp...    74   2e-12
UniRef50_A0JSM2 Putative uncharacterized protein n=7 Tax=Bacteri...    73   2e-12
UniRef50_B2HZD9 6-pyruvoyl-tetrahydropterin synthase n=31 Tax=Pr...    73   2e-12
UniRef50_Q4LA59 Similar to 6-pyruvoyl tetrahydropterin synthase ...    73   2e-12
UniRef50_B2RKC2 Putative uncharacterized protein n=3 Tax=Bacteri...    73   3e-12
UniRef50_D2RQ20 6-pyruvoyl-tetrahydropterin synthase-like protei...    72   4e-12
UniRef50_B5JFE1 Putative uncharacterized protein n=1 Tax=Verruco...    71   1e-11
UniRef50_D2R465 6-pyruvoyl tetrahydrobiopterin synthase; K01737 ...    71   1e-11
UniRef50_D0MWX1 Putative uncharacterized protein n=2 Tax=Phytoph...    71   1e-11
UniRef50_B6KR79 Putative uncharacterized protein n=3 Tax=Toxopla...    70   2e-11
UniRef50_Q4JIS7 Putative 6-pyruvoyl tetrahydropterin synthase n=...    70   2e-11
UniRef50_D1W1T6 Conserved domain protein (Fragment) n=4 Tax=Bact...    70   2e-11
UniRef50_UPI0001AF6FD6 hypothetical protein MkanA1_23688 n=1 Tax...    69   4e-11
UniRef50_B9LV86 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Hal...    68   1e-10
UniRef50_Q1D8H8 Putative uncharacterized protein n=1 Tax=Myxococ...    67   2e-10
UniRef50_A9KBA1 Queuosine biosynthesis protein n=7 Tax=Gammaprot...    66   3e-10
UniRef50_B8C0F3 Predicted protein n=1 Tax=Thalassiosira pseudona...    66   4e-10
UniRef50_A4TYV7 Putative uncharacterized protein n=1 Tax=Magneto...    65   7e-10
UniRef50_B0R4P7 6-pyruvoyltetrahydropterin synthase n=4 Tax=Halo...    64   2e-09
UniRef50_B7FYC8 Predicted protein n=1 Tax=Phaeodactylum tricornu...    63   2e-09
UniRef50_Q18HJ5 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n...    63   2e-09
UniRef50_P80081 6-pyruvoyl tetrahydrobiopterin synthase (Fragmen...    63   3e-09
UniRef50_C9ZBP0 Putative uncharacterized protein n=2 Tax=Strepto...    63   3e-09
UniRef50_D2EHH0 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Ped...    63   3e-09
UniRef50_A9LH53 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=unc...    62   4e-09
UniRef50_Q0AV03 6-pyruvoyl-tetrahydropterin synthase related dom...    62   6e-09
UniRef50_B6IVH4 6-pyruvoyl tetrahydropterin synthase, putative n...    61   8e-09
UniRef50_Q9ZKR8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=14...    61   9e-09
UniRef50_D1B474 Putative uncharacterized protein n=3 Tax=Campylo...    61   1e-08
UniRef50_B6R1Q6 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Pse...    61   1e-08
UniRef50_Q58668 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    61   1e-08
UniRef50_Q1LPD9 6-pyruvoyl-tetrahydropterin synthase-like protei...    61   1e-08
UniRef50_D0LLG1 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Hal...    61   1e-08
UniRef50_B9Z9U9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Hal...    60   2e-08
UniRef50_UPI0001AF6FD4 hypothetical protein MkanA1_23678 n=2 Tax...    60   2e-08
UniRef50_A9G7Q3 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sora...    60   3e-08
UniRef50_C5SEY8 Putative uncharacterized protein n=1 Tax=Asticca...    60   3e-08
UniRef50_Q19Z82 Gp4 n=2 Tax=unclassified Siphoviridae RepID=Q19Z...    59   4e-08
UniRef50_Q4A0G7 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    58   8e-08
UniRef50_A7IHR5 Putative uncharacterized protein n=4 Tax=Bacteri...    58   1e-07
UniRef50_Q6MLZ0 6-pyruvoyl-tetrahydropterin synthase, putative n...    58   1e-07
UniRef50_A8AAK9 Putative uncharacterized protein n=1 Tax=Ignicoc...    57   1e-07
UniRef50_C2FQF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Lac...    56   3e-07
UniRef50_B7FTA7 Predicted protein n=1 Tax=Phaeodactylum tricornu...    56   3e-07
UniRef50_Q3ISX3 Homolog to 6-pyruvoyltetrahydropterin synthase (...    56   4e-07
UniRef50_A4EHB1 6-pyruvoyl tetrahydropterin synthase n=14 Tax=Ba...    56   4e-07
UniRef50_A9HRF7 Putative uncharacterized protein n=3 Tax=Acetoba...    55   6e-07
UniRef50_C7XH17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Lac...    55   9e-07
UniRef50_C5SCP3 Putative uncharacterized protein n=1 Tax=Allochr...    55   9e-07
UniRef50_A7VEN5 Putative uncharacterized protein n=1 Tax=Clostri...    54   1e-06
UniRef50_Q8UVX7 Pyruvoyl-tetrahydropterine synthase (Fragment) n...    53   3e-06
UniRef50_C7JGU4 Putative uncharacterized protein n=8 Tax=Acetoba...    52   5e-06
UniRef50_Q6MLN9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdel...    51   9e-06
UniRef50_Q97FZ8 6-pyruvoyl-tetrahydropterin synthase related pro...    51   1e-05
UniRef50_A6DNS1 Putative uncharacterized protein n=1 Tax=Lentisp...    50   1e-05
UniRef50_B4RFN3 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...    50   2e-05
UniRef50_C5KJI5 Putative uncharacterized protein (Fragment) n=2 ...    50   2e-05
UniRef50_UPI0001B4C1FC hypothetical protein ShygA5_47370 n=1 Tax...    50   3e-05
UniRef50_A5GJQ8 6-pyruvoyl tetrahydropterin synthase n=24 Tax=Cy...    49   5e-05
UniRef50_B8KQC4 6-pyruvoyl tetrahydropterin synthase n=1 Tax=gam...    49   5e-05
UniRef50_A8SSX5 Putative uncharacterized protein n=2 Tax=Clostri...    47   1e-04
UniRef50_A6GII1 Putative uncharacterized protein n=1 Tax=Plesioc...    47   2e-04
UniRef50_D0XQU8 Putative uncharacterized protein n=1 Tax=Brevund...    47   2e-04

>UniRef50_P65871 6-carboxy-5,6,7,8-tetrahydropterin synthase n=102
           Tax=Proteobacteria RepID=QUED_ECO57
          Length = 121

 Score =  202 bits (516), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 121/121 (100%), Positives = 121/121 (100%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA
Sbjct: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG
Sbjct: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120

Query: 121 E 121
           E
Sbjct: 121 E 121


>UniRef50_A0PNB2 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Mycobacterium
           RepID=A0PNB2_MYCUA
          Length = 160

 Score =  179 bits (454), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 72/122 (59%), Positives = 94/122 (77%), Gaps = 2/122 (1%)

Query: 1   MMST-TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
           MM T  ++ +FTFE+AHRLP+VP GHKCGRLHGHS+  R  + G VDP  GWI+DF ++K
Sbjct: 1   MMDTAEIYCEFTFESAHRLPNVPAGHKCGRLHGHSYRARTYVEGPVDPRAGWIVDFGKIK 60

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-LLSAVMVKETCTAGCIY 118
            A KP   RLDH+YLN+I GLENPTSE L+ WIW ++  ++P ++SAV V ETC++GC+Y
Sbjct: 61  DACKPVIARLDHYYLNEIDGLENPTSEQLSMWIWRELATLLPMMMSAVSVSETCSSGCMY 120

Query: 119 RG 120
           RG
Sbjct: 121 RG 122


>UniRef50_A6EFM8 6-pyruvoyl tetrahydrobiopterin synthase, putative n=2 Tax=Bacteria
           RepID=A6EFM8_9SPHI
          Length = 117

 Score =  178 bits (453), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 58/117 (49%), Positives = 82/117 (70%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K F+F++AH LP VP  HKCGR+HGH++ + + ++G  DPH+GW+ DF +LK   +
Sbjct: 1   MIIYKKFSFDSAHYLPLVPASHKCGRMHGHTYQLTVYLSGTPDPHSGWVADFGDLKRGIQ 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           P  + LDH  LNDIPGLENPTSE L+ W+W ++KPV P L+ + + ET   G IY G
Sbjct: 61  PFVDLLDHRLLNDIPGLENPTSENLSVWLWQKIKPVFPALAKIELSETPGTGVIYEG 117


>UniRef50_B2IGN7 Queuosine biosynthesis protein QueD n=4 Tax=Rhizobiales
           RepID=B2IGN7_BEII9
          Length = 117

 Score =  174 bits (441), Expect = 9e-43,   Method: Composition-based stats.
 Identities = 66/117 (56%), Positives = 83/117 (70%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + + F FEAAHRLP VPEGH+C  LHGHS+ V L + G VDP TG++IDF +++A F 
Sbjct: 1   MKITQAFHFEAAHRLPKVPEGHRCANLHGHSYRVELYLEGPVDPDTGFVIDFFDIEAVFG 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           P   RLDHHYLN+I GLENPT+E++A WIWD+VKP +P L  V+V ET      Y G
Sbjct: 61  PLLHRLDHHYLNEIEGLENPTAELIAVWIWDRVKPSLPQLVKVIVYETPDCWAEYEG 117


>UniRef50_Q8K9D8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=210 Tax=Bacteria
           RepID=QUED_BUCAP
          Length = 120

 Score =  173 bits (440), Expect = 1e-42,   Method: Composition-based stats.
 Identities = 77/119 (64%), Positives = 101/119 (84%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M T +FKDF FEAAH LP+VP+ HKC RLHGHSF VRLE+  +++   GWIID+AE+K A
Sbjct: 1   MKTIIFKDFQFEAAHYLPYVPKMHKCRRLHGHSFFVRLELKDKINEKNGWIIDYAEIKLA 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           F+P Y++LDHH+LNDIPGLENPTSE+LAKWIW ++KP + +L+ +++KETCT+GCIY+G
Sbjct: 61  FQPIYDQLDHHFLNDIPGLENPTSEILAKWIWHRLKPKLSILNTIIIKETCTSGCIYQG 119


>UniRef50_B3DVJ6 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bacteria
           RepID=B3DVJ6_METI4
          Length = 161

 Score =  167 bits (423), Expect = 1e-40,   Method: Composition-based stats.
 Identities = 60/120 (50%), Positives = 77/120 (64%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L KDF FEAA  LP  PEGHKC R HGHSF + + + GEVDP  G + D  ++  A
Sbjct: 42  MHVILSKDFDFEAAQALPSFPEGHKCRRTHGHSFKLTVSVRGEVDPQKGVLYDHGKISEA 101

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
             P  E+LDH+YLNDI GL NPT E +A W W+++K  +P L  + ++ET    CIYRG+
Sbjct: 102 VCPLIEQLDHYYLNDIEGLSNPTIENMAGWFWNKLKDKLPGLYEITIQETARTRCIYRGD 161


>UniRef50_Q6MLY9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLY9_BDEBA
          Length = 135

 Score =  160 bits (406), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 55/117 (47%), Positives = 79/117 (67%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L + F  E+A  LPH+P  H C R+HGHSF + L + G++DP  GW+ID+ +++A 
Sbjct: 16  MKFELKQHFQIESARFLPHLPASHPCSRMHGHSFKLILTLVGDLDPKIGWVIDYNDIQAL 75

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
            KP  +++DH  LN++PGLENPTSE+LAKW++D+ +P +P L  V V ET    C Y
Sbjct: 76  MKPLLDQIDHRVLNEVPGLENPTSELLAKWLYDKARPFLPTLVKVTVAETPATECSY 132


>UniRef50_C5SC00 Putative uncharacterized protein n=1 Tax=Allochromatium vinosum DSM
           180 RepID=C5SC00_CHRVI
          Length = 364

 Score =  157 bits (399), Expect = 8e-38,   Method: Composition-based stats.
 Identities = 61/118 (51%), Positives = 76/118 (64%), Gaps = 1/118 (0%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L++ F FE+AHRLP+VPEGH CGR+HGH F V L    ++       IDF  L A +
Sbjct: 120 HAHLWRRFRFESAHRLPNVPEGHPCGRMHGHGFEVILHADQDLGGQD-MGIDFDRLAALW 178

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            P ++ L    LNDIPGLENPTSE L+ WIW ++KP +P LS V V ET TAGC + G
Sbjct: 179 TPLHDELHQVCLNDIPGLENPTSERLSSWIWSRLKPELPALSWVTVYETATAGCHFDG 236



 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 46/117 (39%), Positives = 71/117 (60%), Gaps = 4/117 (3%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              ++K+  FEAA RL   PEG    RLHGHS+++RL +T  +D   GW +D+ ++K  F
Sbjct: 238 HYRIWKEQRFEAALRLERSPEGDARRRLHGHSYLLRLHLTAPLDQVLGWTVDYGDVKRLF 297

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           KP Y+RLDHH L+ + GLE  +P S  L +WI ++++  +P L  + ++ T   G  
Sbjct: 298 KPLYDRLDHHRLDALDGLEAADPGS--LIRWIRERIQDDLPELDRIDLQPTPGCGAS 352



 Score = 80.1 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 39/109 (35%), Positives = 60/109 (55%), Gaps = 4/109 (3%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           FEAA R+  +PEGH+C RLHGHSF+ ++     +        +  +L+AA     E LD+
Sbjct: 13  FEAACRVDILPEGHRCRRLHGHSFLAQVRAELPLGWAGFPGAESDDLQAALACCVEPLDY 72

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
             LN I  +  PT E LA+W+ D++   VP +++V ++ T   G    G
Sbjct: 73  RDLNAILPI--PTDENLARWVRDRL--DVPGIASVGIQSTRDQGADLDG 117


>UniRef50_UPI0001C165E4 Dihydropteroate synthase n=1 Tax=Raphidiopsis brookii D9
           RepID=UPI0001C165E4
          Length = 450

 Score =  154 bits (391), Expect = 5e-37,   Method: Composition-based stats.
 Identities = 52/120 (43%), Positives = 77/120 (64%), Gaps = 7/120 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAELK 59
             + K+F FEAAH+LP+     KC RLH HS+   + + G+   ++G     I+D+ ++ 
Sbjct: 321 WIIGKEFRFEAAHQLPN--HDGKCARLHDHSWRGVVYVAGDKLINSGVKQGMIMDYGDIS 378

Query: 60  AAFKPTYER-LDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
              KP  E  LDH++LN+  GL NPTSE +AKWI++Q++P +P L AV + ETCT+ CIY
Sbjct: 379 KYIKPLLENYLDHYHLNESTGLANPTSEAIAKWIYEQLEPQIPGLVAVRIDETCTSQCIY 438


>UniRef50_C6QGG4 Queuosine biosynthesis protein QueD n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QGG4_9RHIZ
          Length = 181

 Score =  149 bits (377), Expect = 2e-35,   Method: Composition-based stats.
 Identities = 49/114 (42%), Positives = 68/114 (59%), Gaps = 1/114 (0%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +   +TFEAAH LP V +GHKC RLHGH++ V + + G +D   G+++D+AEL    +
Sbjct: 67  IRITATYTFEAAHFLPKVHDGHKCRRLHGHNYRVDVSVAGGLD-ERGFVLDYAELDGIVQ 125

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           P  + LDH  LNDIPGLENPTSE+LA W+  ++         + V ET      
Sbjct: 126 PVIDELDHRCLNDIPGLENPTSEILALWLRSRIAAKAGTKPMIRVWETPRYLVE 179


>UniRef50_C6QCT4 Putative uncharacterized protein n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCT4_9RHIZ
          Length = 140

 Score =  147 bits (373), Expect = 7e-35,   Method: Composition-based stats.
 Identities = 56/121 (46%), Positives = 73/121 (60%), Gaps = 1/121 (0%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
             +  ++KDF FEAAH LP    G    R+HGHSF  R+ + GE    TG+I  F EL +
Sbjct: 10  FSAMQIYKDFRFEAAHFLPSAAPGTPNARVHGHSFRARVVVEGEPGRDTGYIFHFDELSS 69

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYR 119
           A + T E LDH  LNDI GL  PT E +A WIW+++   VP L  V V +++C  GC+YR
Sbjct: 70  ALRETEEDLDHRMLNDIEGLSAPTLERIAMWIWNRLSNRVPGLVQVEVHRDSCNEGCVYR 129

Query: 120 G 120
           G
Sbjct: 130 G 130


>UniRef50_A4XG23 Putative uncharacterized protein n=4 Tax=Bacteria
           RepID=A4XG23_CALS8
          Length = 121

 Score =  146 bits (370), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 52/121 (42%), Positives = 70/121 (57%), Gaps = 10/121 (8%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KP 64
           L K F F+AAH L       KC RLHGH++ + + + G++D     +IDFA LK    K 
Sbjct: 3   LKKIFKFDAAHNLTKY--HGKCERLHGHTYKLVVTVKGKLDEQD-MVIDFALLKDIVQKE 59

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIYRG 120
             + LDH YLNDI  +ENPT+E +AKWIW ++   +      L  V V ET  +G +YRG
Sbjct: 60  VIDILDHAYLNDI--IENPTAENIAKWIWQRLYDKIKAQNSTLYEVEVWETEDSGAVYRG 117

Query: 121 E 121
           E
Sbjct: 118 E 118


>UniRef50_B7K1S3 Queuosine biosynthesis protein QueD n=6 Tax=Cyanobacteria
           RepID=B7K1S3_CYAP8
          Length = 136

 Score =  146 bits (369), Expect = 2e-34,   Method: Composition-based stats.
 Identities = 54/122 (44%), Positives = 81/122 (66%), Gaps = 8/122 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAEL 58
           +  +FK+F FEAAHRLPH     KC RLHGHS++ R+ + G+      P  G I+DF+++
Sbjct: 8   NWLIFKEFRFEAAHRLPHYD--GKCHRLHGHSWVGRIYVQGDRLVKDGPKQGMIMDFSDI 65

Query: 59  KAAFKPTYER-LDHHYLNDIPGLENPTSEVLAKWIWDQVKPV-VPLLSAVMVKETCTAGC 116
           +   +P  E  LDH+YLN+  GLENPT E +A+WI+++++   +  L AV ++ETCT+G 
Sbjct: 66  QRYLEPLLENFLDHYYLNETMGLENPTCEAVAQWIFEKLEKAGLQGLQAVEIQETCTSGV 125

Query: 117 IY 118
            Y
Sbjct: 126 RY 127


>UniRef50_B6CWI6 ToyB n=5 Tax=Bacteria RepID=B6CWI6_STRRM
          Length = 131

 Score =  145 bits (368), Expect = 3e-34,   Method: Composition-based stats.
 Identities = 46/119 (38%), Positives = 70/119 (58%), Gaps = 2/119 (1%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG--EVDPHTGWIIDFAELKAA 61
             + K+F F A+HRL H+ EGH C R+HGH+++V LE++   +     G++ D+ EL A 
Sbjct: 13  FRISKEFHFSASHRLDHLDEGHPCSRMHGHNYVVELELSAGDDALTKAGFVRDYGELAAF 72

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            +     LDH +LND+    NP++E LA+WI ++ +   P L+AV V ET      YR 
Sbjct: 73  KQWLDAELDHRHLNDVVDGLNPSAENLARWIHERWRTGFPELTAVRVSETDKTWAEYRA 131


>UniRef50_C9RBW1 Putative uncharacterized protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RBW1_AMMDK
          Length = 124

 Score =  144 bits (363), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 44/124 (35%), Positives = 64/124 (51%), Gaps = 10/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L    +F AAHRLP+ P    C RLHGH++ V + + GE     G ++DF  LK   
Sbjct: 1   MYRLTVKGSFSAAHRLPNHP--SPCSRLHGHNWEVTVTVIGEELGPDGMLLDFTVLKQIL 58

Query: 63  KPTYERLDHHYLNDIPGLEN---PTSEVLAKWIWDQVKPVVP-----LLSAVMVKETCTA 114
           +    +LDH YLN+IP       PT+E LA++I+ +V   +       L  V V E+ +A
Sbjct: 59  QEVLAKLDHQYLNEIPPFGKELPPTAENLARYIYHEVATRLAPYPAVTLQEVKVGESPSA 118

Query: 115 GCIY 118
             +Y
Sbjct: 119 WVVY 122


>UniRef50_Q2IJB0 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Anaeromyxobacter
           RepID=Q2IJB0_ANADE
          Length = 129

 Score =  143 bits (362), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 45/119 (37%), Positives = 67/119 (56%), Gaps = 5/119 (4%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L  +F F AAHRLP       C R+HGH++   + + GEVDP TG I DF ++K   
Sbjct: 11  RMRLDVEFYFAAAHRLPRYE--GPCFRMHGHNYRFFVALEGEVDPATGMIADFGDVKRIV 68

Query: 63  KP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
                 R+DH  LND+  L+NPT+E +A+W+W+ ++P +  L  + + E   +   YRG
Sbjct: 69  AEHVLARVDHRTLNDV--LDNPTAENIARWMWEVLEPHLAGLCEIRLYEIPDSCVTYRG 125


>UniRef50_C9KKI2 Queuosine biosynthesis protein QueD n=2 Tax=Veillonellaceae
           RepID=C9KKI2_9FIRM
          Length = 136

 Score =  141 bits (357), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 43/124 (34%), Positives = 64/124 (51%), Gaps = 10/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL  +  FEAAHR+ + P   KC RLHGH++ V   + G      G ++DF  +K A 
Sbjct: 12  MYTLKVEGAFEAAHRVVNYP--GKCDRLHGHNWKVEAVVRGTELDELGMLVDFKAIKNAL 69

Query: 63  KPTYERLDHHYLNDIPGLE---NPTSEVLAKWIWDQVKP-----VVPLLSAVMVKETCTA 114
           K   +R DH +LN++       NPT+E LA+ I++++           L A+ V ET T+
Sbjct: 70  KGVLDRFDHRFLNELEPFAAGINPTAENLARIIFEELAGNDAFVRDSELFAITVYETPTS 129

Query: 115 GCIY 118
              Y
Sbjct: 130 SVTY 133


>UniRef50_B5YCT3 6-pyruvoyl-tetrahydropterin synthase n=24 Tax=Bacteria
           RepID=B5YCT3_DICT6
          Length = 125

 Score =  140 bits (355), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 47/121 (38%), Positives = 68/121 (56%), Gaps = 10/121 (8%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK-P 64
           + + F F+AAH L       KC RLHGH++ + + + G  D   G IIDF ELK   K  
Sbjct: 3   VIRKFKFDAAHNLESYK--GKCERLHGHTYRLVVIVEGIPDSE-GMIIDFVELKDIVKRE 59

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCIYRG 120
             + LDH Y+N+I  ++ PT+E +A WIW +++  +      L  + V ET  +G IYRG
Sbjct: 60  VIDILDHSYINEI--IKQPTAENIAIWIWQRLEEKLKRGNCHLYEIQVWETEDSGVIYRG 117

Query: 121 E 121
           E
Sbjct: 118 E 118


>UniRef50_Q1NNH1 Putative uncharacterized protein n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NNH1_9DELT
          Length = 122

 Score =  140 bits (354), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 38/121 (31%), Positives = 61/121 (50%), Gaps = 8/121 (6%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           +F +  F + H L + P    C + HGH++ V + +  +     G  +DF +LK A K  
Sbjct: 4   IFTESHFSSGHHLRNYP--GNCEKPHGHNWKVEVTVRADELDQLGMGLDFRDLKGAVKEV 61

Query: 66  YERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIYR 119
            + LDH  LND P  +  NP+SE +A++I+ ++K  +         V V+ET   G  YR
Sbjct: 62  VDDLDHRDLNDHPAFQEINPSSENIARYIFVELKKRLQNDRCRPHKVTVRETDACGVTYR 121

Query: 120 G 120
            
Sbjct: 122 E 122


>UniRef50_Q2K3W9 6-pyruvoyl tetrahydropterin synthase protein n=19
           Tax=Alphaproteobacteria RepID=Q2K3W9_RHIEC
          Length = 119

 Score =  140 bits (353), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 43/118 (36%), Positives = 66/118 (55%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K+F   A+H+L H+P  H+C RLHGH+++V +E++ E     G++ D+ +L   
Sbjct: 1   MMYRITKEFHLSASHQLDHLPADHQCARLHGHNYVVVVELSAENLNDDGFVRDYHDLAPL 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
            +   E LDH +LN++ G    TSE LAK  +D  +   P  S+V V ET      YR
Sbjct: 61  KRYIDESLDHRHLNEVFGHSKVTSEFLAKHFYDWCRERFPETSSVRVSETPKTWAEYR 118


>UniRef50_D0B3L9 6-pyruvoyl tetrahydrobiopterin synthase n=47 Tax=Bacteria
           RepID=D0B3L9_BRUME
          Length = 121

 Score =  140 bits (353), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 43/117 (36%), Positives = 64/117 (54%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + K+F F A+H+L  +P  H+C RLHGH+++V +E++       G++ D+ EL A  
Sbjct: 1   MFRITKEFHFSASHQLTGLPADHQCARLHGHNYIVEVELSAPDLDTHGFVRDYHELAALK 60

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
               +  DH +LND+ G E  T+E LAK  +D      P +SAV V ET      YR
Sbjct: 61  HYIDDTFDHRHLNDVLGHEQTTAERLAKHFFDWCHARWPEISAVRVSETPKTWAEYR 117


>UniRef50_C9LTT9 Queuosine biosynthesis protein QueD n=3 Tax=Bacteria
           RepID=C9LTT9_9FIRM
          Length = 125

 Score =  140 bits (353), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 43/127 (33%), Positives = 66/127 (51%), Gaps = 10/127 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  +  FEAAHR+ + P   KC RLHGH++ V L+I+G      G +IDF   KA  
Sbjct: 1   MFEIKVEEEFEAAHRIVNYP--GKCDRLHGHNWKVELKISGSRLDELGMLIDFKAAKAML 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV------PLLSAVMVKETCTA 114
           +     LDH +LN++      NPT+E +A++I+ ++K           L+AV V E+  A
Sbjct: 59  QEVVNSLDHRFLNELEPFSEINPTAENIARYIYQELKQREIFCNDSVHLAAVCVWESPRA 118

Query: 115 GCIYRGE 121
              Y  +
Sbjct: 119 CATYTED 125


>UniRef50_Q55798 6-carboxy-5,6,7,8-tetrahydropterin synthase n=7 Tax=Bacteria
           RepID=QUED_SYNY3
          Length = 129

 Score =  139 bits (352), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 55/122 (45%), Positives = 76/122 (62%), Gaps = 8/122 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP----HTGWIIDFAEL 58
              ++K+F+FEAAH+LPH     KC RLHGHSF  R+ +  +        TG ++DF+ L
Sbjct: 1   MWIIYKEFSFEAAHQLPHHE--GKCRRLHGHSFRGRVYVASDRLKTTGSETGMVMDFSVL 58

Query: 59  KAAFKPTYE-RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPV-VPLLSAVMVKETCTAGC 116
           KA   P  +  LDH+YLND  GLE+PTSE +A WI+ +++   VP L +V V ETCT+  
Sbjct: 59  KAHLDPLVKNHLDHYYLNDSLGLESPTSEAIAAWIFAKLEEAGVPGLHSVEVLETCTSAA 118

Query: 117 IY 118
            Y
Sbjct: 119 RY 120


>UniRef50_Q3ADI6 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3ADI6_CARHZ
          Length = 120

 Score =  139 bits (351), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 40/121 (33%), Positives = 61/121 (50%), Gaps = 8/121 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    TF+AAH L       KC  LHGH++ V  E+ G+     G +IDF  +K   
Sbjct: 1   MFKISVSTTFDAAHFLKDYD--GKCANLHGHTWRVEAEVEGQTTNDLGLLIDFGMIKDYL 58

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL-----LSAVMVKETCTAGCI 117
           K    RLDH  LND+  + NPT+E +A++I+ ++K  + +     L +V V E+      
Sbjct: 59  KDITSRLDHKLLNDVLQV-NPTAENIARYIFKELKAKLIVYPEIKLCSVKVWESPNNAAT 117

Query: 118 Y 118
           Y
Sbjct: 118 Y 118


>UniRef50_A7HXX3 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Parvibaculum
           lavamentivorans DS-1 RepID=A7HXX3_PARL1
          Length = 122

 Score =  138 bits (349), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 50/118 (42%), Positives = 72/118 (61%), Gaps = 1/118 (0%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K+F F+AAH LP+  EGH   R+HGHSF V + + G+    TG +  F +++    
Sbjct: 1   MKIYKEFLFDAAHFLPYAEEGHPNRRMHGHSFRVVVWLKGKPAAETGIVRHFEDVEREIM 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYRG 120
              E+LDHH LN+I GLE PT E +A WIWD +   +P ++ V V + +C  GCIY G
Sbjct: 61  AVREKLDHHLLNEIEGLEFPTLERIAAWIWDALATPLPEIARVEVHRASCREGCIYDG 118


>UniRef50_Q2IKV5 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Anaeromyxobacter
           RepID=Q2IKV5_ANADE
          Length = 138

 Score =  138 bits (348), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 11/129 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
               + KDF F AAH++     G KC RLHGH++ VR+          G +IDFA+L+  
Sbjct: 12  PVYEISKDFVFSAAHQIRF--HGGKCERLHGHNWRVRVHARASTLNRIGMVIDFADLQKL 69

Query: 62  FKPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLL-------SAVMVKETC 112
                 R DH  +N++     EN T+E++A++ + ++   +  L       + V V E  
Sbjct: 70  VAEVGSRFDHQNVNEVAPFDQENTTAELIARFFYREMSRRLAELEGGRVTVARVDVWENE 129

Query: 113 TAGCIYRGE 121
            +  IYR E
Sbjct: 130 GSLAIYREE 138


>UniRef50_B9K796 Queuosine biosynthesis protein QueD n=2 Tax=Bacteria
           RepID=B9K796_THENN
          Length = 131

 Score =  137 bits (347), Expect = 8e-32,   Method: Composition-based stats.
 Identities = 48/124 (38%), Positives = 74/124 (59%), Gaps = 10/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           +  L K F+FEAAH L  V    KC RLHGH++ + +++ G ++     ++DFAELK   
Sbjct: 11  NMVLVKKFSFEAAHNL--VKYHGKCERLHGHTYRLTVKVEGPLNEED-MVMDFAELKKMV 67

Query: 63  KP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCI 117
           +    ++LDH YLN++   E PT+E +A WIW+Q+   +      L  + + ET T+G +
Sbjct: 68  EDRVIKKLDHSYLNEL--FEQPTTERVAIWIWEQLSGPLRECGVRLVEIELWETETSGVV 125

Query: 118 YRGE 121
           YRGE
Sbjct: 126 YRGE 129


>UniRef50_B5JVD7 Probable 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=gamma
           proteobacterium HTCC5015 RepID=B5JVD7_9GAMM
          Length = 332

 Score =  137 bits (346), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 61/121 (50%), Positives = 75/121 (61%), Gaps = 8/121 (6%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M  +  ++ + FEAAH LP+VPEGHKCGRLHGH F V L           W  +   L  
Sbjct: 96  MGDSYQWRRYRFEAAHFLPNVPEGHKCGRLHGHGFEVTL------LAPLRWSAE--SLDE 147

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            ++P YERL  H LN I GLENPTSEVLA+WIW Q+   +  L +V V+ET TAGC Y G
Sbjct: 148 HWQPLYERLHGHCLNRIVGLENPTSEVLAEWIWRQLIDSITDLLSVDVRETVTAGCRYDG 207

Query: 121 E 121
           +
Sbjct: 208 Q 208



 Score = 84.4 bits (208), Expect = 9e-16,   Method: Composition-based stats.
 Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 6/113 (5%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
            ++K    E A +L    E        GHS+ VRL +   +D   GW  D+ ++K  F+P
Sbjct: 211 RIWKQQEAECAVQLAGFDEPM------GHSYRVRLHLEAPLDKVMGWTQDYGDVKTQFQP 264

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
            Y +LDHH LN+I     P+   +A+W+   +   +P L+ + V  T   G I
Sbjct: 265 LYRQLDHHCLNEILPSGEPSDLAVAEWLRQGLGEALPALNRIDVHSTPEEGAI 317


>UniRef50_B9ZMJ4 Queuosine biosynthesis protein QueD n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZMJ4_9GAMM
          Length = 127

 Score =  137 bits (345), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 41/125 (32%), Positives = 62/125 (49%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL     F +AH L   P   +C  +HGH++ V  E+  E     G  +DF  +K A 
Sbjct: 4   RYTLRVLTDFASAHTLRDYP--GQCANMHGHNWKVEAEVQAETLDDAGMAVDFKVVKTAA 61

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV--PLL--SAVMVKETCTAGC 116
           +    +LDH YLND+P  +  NPT+E +A+W + Q+   +  P L   A+ + ET  A  
Sbjct: 62  REIAGQLDHRYLNDVPPFDTVNPTAENIAQWFFRQMSERLNRPGLRMHALTLWETDRACV 121

Query: 117 IYRGE 121
            Y  +
Sbjct: 122 RYSED 126


>UniRef50_B5YJJ7 6-pyruvoyl-tetrahydropterin synthase n=4 Tax=Bacteria
           RepID=B5YJJ7_THEYD
          Length = 122

 Score =  137 bits (345), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 39/113 (34%), Positives = 58/113 (51%), Gaps = 8/113 (7%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F+AAH+L       KC  +HGH++ V +E+  E     G  +DF ELK        +LDH
Sbjct: 10  FDAAHQLKGYK--GKCENIHGHNWKVEVEVISEKLNEIGIALDFKELKKNVDEVVSQLDH 67

Query: 72  HYLNDIPGLE--NPTSEVLAKWIW----DQVKPVVPLLSAVMVKETCTAGCIY 118
            ++N IP     NP+SE +A+WI+    D+    +  L +V V E+  A   Y
Sbjct: 68  TFINQIPPFTQLNPSSENIARWIYMSLKDKFNTTLVRLYSVTVWESDYASATY 120


>UniRef50_Q0BPQ0 Queuosine biosynthesis protein queD n=2 Tax=Proteobacteria
           RepID=Q0BPQ0_GRABC
          Length = 130

 Score =  136 bits (344), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 44/117 (37%), Positives = 64/117 (54%), Gaps = 1/117 (0%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
            + K FTFEAAH L    E     R+HGHS+ V + + G VDP +G ++D   L+     
Sbjct: 13  EIGKQFTFEAAHTLHREIETDSSLRIHGHSYRVEVVLRGGVDPDSGMLMDLGLLQRKMNA 72

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIYRG 120
             + LDH  L+++PGL   T E +A +IW  + P +P L+ V V ++T    C  RG
Sbjct: 73  VRDALDHRLLDEVPGLAPATMENIALFIWRHLAPDLPALAEVSVFRDTLGERCTCRG 129


>UniRef50_Q2LVK6 Queuosine biosynthesis protein n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVK6_SYNAS
          Length = 159

 Score =  136 bits (343), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 39/123 (31%), Positives = 62/123 (50%), Gaps = 8/123 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +  +  F AAH L + P    C  LHGH++ V + +  E     G  IDF E+K + +
Sbjct: 38  FEISIEEQFSAAHALRNYP--GNCEHLHGHNWAVEVTVECEELNEIGIGIDFREVKQSVR 95

Query: 64  PTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCI 117
               RLDH  LN++P     NP+SE +A+ +++++   +      +S V V ET T+   
Sbjct: 96  EALHRLDHVNLNELPQFCDINPSSENIARHLYNELSRKLNTEKIRVSRVRVSETPTSKAS 155

Query: 118 YRG 120
           YR 
Sbjct: 156 YRE 158


>UniRef50_Q03393 6-pyruvoyl tetrahydrobiopterin synthase n=19 Tax=Bilateria
           RepID=PTPS_HUMAN
          Length = 145

 Score =  136 bits (343), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 42/135 (31%), Positives = 71/135 (52%), Gaps = 16/135 (11%)

Query: 3   STTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWI 52
              + +  +F A+HRL         ++    KC     HGH++ V + + GE+DP TG +
Sbjct: 11  QAQVSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMV 70

Query: 53  IDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAV 106
           ++ A+LK   +    + LDH  L+ D+P   +   T+E +A +IWD ++ V+P  +L  V
Sbjct: 71  MNLADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKV 130

Query: 107 MVKETCTAGCIYRGE 121
            V ET     +Y+GE
Sbjct: 131 KVYETDNNIVVYKGE 145


>UniRef50_Q0RM63 6-pyruvoyl tetrahydrobiopterin synthase n=11 Tax=Bacteria
           RepID=Q0RM63_FRAAA
          Length = 130

 Score =  135 bits (342), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 46/124 (37%), Positives = 67/124 (54%), Gaps = 5/124 (4%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M +  + K F F A+HRL  +P  HKC RLHGH++ VR+++ GE     G+++D+ EL  
Sbjct: 3   MPAFEISKTFEFSASHRLSGLPADHKCARLHGHNYTVRVQLRGETLDPVGFLLDYGELSP 62

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLS----AVMVKETCTAGC 116
                   LDH +LN      NPT+E+LA+ +   V+ +VP+      AV V ET     
Sbjct: 63  VRDWIDAALDHQHLNACLDF-NPTAELLAQHLAGTVRQLVPIPDGVRVAVGVSETPRTWA 121

Query: 117 IYRG 120
            YR 
Sbjct: 122 FYRE 125


>UniRef50_B9Z1F8 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Neisseriaceae
           RepID=B9Z1F8_9NEIS
          Length = 341

 Score =  135 bits (341), Expect = 4e-31,   Method: Composition-based stats.
 Identities = 58/110 (52%), Positives = 71/110 (64%), Gaps = 7/110 (6%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           FEAAH+LPHVP GHKCGRLHGH F VRL        H        +L AA+   + RL+H
Sbjct: 118 FEAAHQLPHVPAGHKCGRLHGHGFGVRLVADAASANHV-------DLAAAWGRLFLRLNH 170

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
            YLNDIPGL NPTSEVLA+WI+ ++   +  L+ V V+ET TAG  + G 
Sbjct: 171 RYLNDIPGLANPTSEVLAQWIYRELSADLAGLAWVEVRETHTAGSQFDGR 220



 Score = 80.5 bits (198), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 38/114 (33%), Positives = 66/114 (57%), Gaps = 6/114 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K+  FE+A  +P   +G       GHS+++RL + GE+D   GW++DF ++K  FK
Sbjct: 222 FRIWKEQHFESA--VPFDADG----NYTGHSYLIRLMLQGELDGAMGWLLDFGDVKDRFK 275

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           P Y +LDH+ L+ + G+ N     +A+W+  ++ P+VP L+ V + E    G  
Sbjct: 276 PVYRQLDHNPLDRLAGIRNGHPASVAEWVHAELSPLVPELARVDLMERDERGVS 329


>UniRef50_Q1IHK8 Putative uncharacterized protein n=3 Tax=Acidobacteria
           RepID=Q1IHK8_ACIBL
          Length = 125

 Score =  134 bits (339), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 11/127 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  + TF A H L +     KC   HGH++ VR+ + G    H G ++DF +LK   
Sbjct: 1   MYEVTVEDTFAAGHYLRNYK--GKCENPHGHNYKVRVTLQGRELDHAGLLLDFKDLKVVM 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSA-------VMVKETCT 113
           KP  + LDH  +NDIP     NP++E +A++ +D+    +   ++       V + ET T
Sbjct: 59  KPVVDYLDHQMMNDIPPFNEVNPSAENIARYFYDECNKFLAGQTSGRVRVKDVTIWETDT 118

Query: 114 AGCIYRG 120
               Y  
Sbjct: 119 TTATYYE 125


>UniRef50_A1WW30 Putative uncharacterized protein n=1 Tax=Halorhodospira halophila
           SL1 RepID=A1WW30_HALHL
          Length = 258

 Score =  134 bits (337), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 53/114 (46%), Positives = 70/114 (61%), Gaps = 11/114 (9%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           ++ F FEAAHRLP+VPEGH CGR+HGH ++V LE  G          D   L  A+ P  
Sbjct: 38  WRAFRFEAAHRLPYVPEGHPCGRMHGHGYLVVLEAAGG---------DPEALGEAWAPLG 88

Query: 67  ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           + LD   LND   L+NPTSE++A W+W+Q++P  P L  + V ET  +GC Y G
Sbjct: 89  QALDRACLNDF--LDNPTSELIAVWLWEQLRPRCPGLIRLHVHETEHSGCTYDG 140



 Score = 72.8 bits (178), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 40/113 (35%), Positives = 57/113 (50%), Gaps = 2/113 (1%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           T++K   FEAA  +    +     RLHGH + +R+ +T  +D   GW +D+ ++KAAF P
Sbjct: 144 TIWKAQRFEAATCVADADDTR--ARLHGHGYRLRVHVTAPLDRVLGWTLDYGDVKAAFAP 201

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
             E LDH  L+ I GLE+     LA W     +  +P L  V   E    G I
Sbjct: 202 VREALDHQRLDTIAGLESGDVASLAAWAARAARQRLPELLRVDCYERDGVGAI 254


>UniRef50_Q7NSB8 Probable 6-pyruvoyltetrahydrobiopterin synthase n=1
           Tax=Chromobacterium violaceum RepID=Q7NSB8_CHRVO
          Length = 239

 Score =  132 bits (334), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 58/111 (52%), Positives = 72/111 (64%), Gaps = 7/111 (6%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           +FEAAH LPHVP GHKCGRLHGH F VR+                 EL  A+ P + RL+
Sbjct: 15  SFEAAHHLPHVPPGHKCGRLHGHGFGVRIVADAAQCGQ-------RELARAWAPLHRRLN 67

Query: 71  HHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
           HHYLNDI GL+NPTSEVLA+W+  Q+   VP L+ V V+ET +AG  + G+
Sbjct: 68  HHYLNDIAGLDNPTSEVLAQWLHQQLSDAVPGLAWVEVRETHSAGSQFDGK 118



 Score = 86.3 bits (213), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 41/114 (35%), Positives = 68/114 (59%), Gaps = 6/114 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K+  FE+A  +P   +G       GHS++VRL ++G +D   GW++DF ++K  FK
Sbjct: 120 FRIWKEQRFESA--IPFDADG----NYTGHSYLVRLMLSGGIDRTMGWLLDFGDVKDRFK 173

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           P Y +LDH+ L+ + G+    S  +A+WI  Q+ P+VP LS + + E+  AG  
Sbjct: 174 PIYRQLDHNPLDKLAGVRGADSAAVAEWIHAQLSPLVPELSRIDLMESDDAGVS 227


>UniRef50_A8L9C2 Putative uncharacterized protein n=1 Tax=Frankia sp. EAN1pec
           RepID=A8L9C2_FRASN
          Length = 140

 Score =  132 bits (334), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 47/120 (39%), Positives = 66/120 (55%), Gaps = 6/120 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K FTF+AAH LP +P GHKC R+HGH++ V   +        G++ DF +L  A +
Sbjct: 16  FRIGKRFTFDAAHHLPSLPAGHKCSRVHGHTYTVEFVLAASELAGPGFVTDFGDLAVAGR 75

Query: 64  PTYERLDHHYLNDIPGLENPTSE----VLAKWIWDQVKPVV-PLLSAVMVKETCTAGCIY 118
              E  DH  LN++  +E PTSE     LA+W   +V+P V   L AV V ET ++   Y
Sbjct: 76  YLAESFDHRDLNEVLDVE-PTSEALAQHLARWFLAEVEPGVHGRLVAVRVSETPSSWAEY 134


>UniRef50_C8R1L5 Putative uncharacterized protein n=1 Tax=Desulfurivibrio
           alkaliphilus AHT2 RepID=C8R1L5_9DELT
          Length = 123

 Score =  132 bits (333), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 39/125 (31%), Positives = 61/125 (48%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +F    F + H L + P    C + HGH++ V++ +  +     G  +DF +LKAA 
Sbjct: 1   MYEVFTTTHFSSGHHLRNYP--GNCEKPHGHNWKVKVIMRADELDELGMALDFRDLKAAL 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
           K   + LDH  LN+ P    ENP+SE +A++I+ ++K  +         V V ET   G 
Sbjct: 59  KVIIDDLDHRDLNEHPAFQQENPSSENIARYIFAELKKSLSSDRYRPHKVTVLETDACGV 118

Query: 117 IYRGE 121
            Y  E
Sbjct: 119 SYSEE 123


>UniRef50_Q31FT9 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Gammaproteobacteria
           RepID=Q31FT9_THICR
          Length = 125

 Score =  132 bits (332), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 36/124 (29%), Positives = 61/124 (49%), Gaps = 8/124 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F +AH L   P    C +LHGH++ + +++ G+     G ++DF E+K   
Sbjct: 4   QFVLKTLLDFASAHSLRGYP--GDCAKLHGHNWKIEVQVVGDKLNDIGMLVDFKEIKRHA 61

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGC 116
           K     LDH +LND P    +NPT+E +A++I+ Q++  +      + ++ V E      
Sbjct: 62  KEVISELDHTFLNDHPHFKEKNPTAENIAEYIYKQIQQRIQSSTVKMHSLTVWENDRNCV 121

Query: 117 IYRG 120
           IY  
Sbjct: 122 IYSE 125


>UniRef50_C4V0R8 Possible 6-pyruvoyltetrahydropterin synthase n=1 Tax=Selenomonas
           flueggei ATCC 43531 RepID=C4V0R8_9FIRM
          Length = 126

 Score =  131 bits (331), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 42/126 (33%), Positives = 62/126 (49%), Gaps = 11/126 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL  +  FEAAHR+   P   KC RLHGH+++V     G      G +IDF   KAA 
Sbjct: 1   MYTLRVEGAFEAAHRVVGYP--GKCDRLHGHNWVVEAVFRGTELDGLGMLIDFKTAKAAL 58

Query: 63  KPTYERLDHHYLNDIPGLE---NPTSEVLAKWIWDQVKPVV------PLLSAVMVKETCT 113
               +  DH Y+N++P  +   NPT+E LA  I++++            L+A+ V E+  
Sbjct: 59  MAVLDAFDHRYINELPPFDGEVNPTAENLACIIYERLAARTEVMESSAHLAALTVWESPK 118

Query: 114 AGCIYR 119
           +   Y 
Sbjct: 119 SSVTYE 124


>UniRef50_C1SPF1 PreQ(0) biosynthesis protein QueD n=1 Tax=Denitrovibrio acetiphilus
           DSM 12809 RepID=C1SPF1_9BACT
          Length = 122

 Score =  130 bits (329), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 38/120 (31%), Positives = 54/120 (45%), Gaps = 6/120 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    +F  AH L +     KC  LHGH++ V   + G+    T  ++DF  +K   
Sbjct: 1   MYKVRVVMSFGGAHNLRNY--NGKCENLHGHNWKVEAYLKGDELNETEMLVDFTIMKKRL 58

Query: 63  KPTYERLDHHYLNDIPGL---ENPTSEVLAKWIWDQVKPVVPLL-SAVMVKETCTAGCIY 118
           K   E LDH YLN+        NPTSE +A++I+  +K     L   V V ET      Y
Sbjct: 59  KEILETLDHKYLNEQVEFFKVNNPTSENIARYIYQGLKETFGKLTDRVAVWETDIQAAEY 118


>UniRef50_Q3SPB8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Alphaproteobacteria
           RepID=Q3SPB8_NITWN
          Length = 123

 Score =  130 bits (329), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 43/118 (36%), Positives = 60/118 (50%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L K F FEAAH LP    G     +HGHSF   + + G  DP +G ++D   L+   
Sbjct: 1   MWELTKSFRFEAAHALPGTTLGAASMEIHGHSFRAEVSLRGTPDPASGMVLDLGLLERGM 60

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
                +LDH  LND+ GL  PT E LA++IWD V+    +    + +++C   C Y G
Sbjct: 61  GEVRNKLDHKLLNDVEGLGPPTLENLARFIWDHVQHAGAVTRVSVHRDSCGESCAYFG 118


>UniRef50_B0VJG6 6-pyruvoyl tetrahydrobiopterin synthase family protein n=1
           Tax=Candidatus Cloacamonas acidaminovorans
           RepID=B0VJG6_9BACT
          Length = 126

 Score =  130 bits (328), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 40/117 (34%), Positives = 59/117 (50%), Gaps = 8/117 (6%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           TF AAH L        C +LHGH++ VR+ +  +     G  +DF  LK         LD
Sbjct: 9   TFSAAHLLRGYE--GACSKLHGHNWKVRVCVKTKEQDEIGMAMDFGVLKTILSNILNNLD 66

Query: 71  HHYLNDIPGL--ENPTSEVLAKWIWD----QVKPVVPLLSAVMVKETCTAGCIYRGE 121
           H YLN+I      NPTSE LAK+I++    +++     +S V V E+  +  IY+ +
Sbjct: 67  HSYLNEIVPFTERNPTSENLAKYIYECMEKELQDKPVAISEVEVYESEKSSVIYKND 123


>UniRef50_A5D2E2 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Peptococcaceae
           RepID=A5D2E2_PELTS
          Length = 129

 Score =  130 bits (327), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 35/127 (27%), Positives = 60/127 (47%), Gaps = 13/127 (10%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    +F AAH +        C R+HGH+++V   + G      G ++DF E+K   
Sbjct: 1   MYEIVVRTSFAAAHSIKGYD--GPCSRMHGHTWLVEAVLRGGQLDQKGMLVDFKEVKNIL 58

Query: 63  KPTYERLDHHYLNDIPGL-----ENPTSEVLAKWIWDQVKPVVPLLSA------VMVKET 111
           +     LDH  LN+I        ++PT+E +A++++ ++KP +  L        V V E+
Sbjct: 59  RSAVGELDHQNLNEIKPFAGGSGDSPTAENIARYLFCRIKPEIVKLERNIHLAMVRVWES 118

Query: 112 CTAGCIY 118
            TA   Y
Sbjct: 119 DTAAASY 125


>UniRef50_B4RHW0 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Caulobacteraceae
           RepID=B4RHW0_PHEZH
          Length = 125

 Score =  130 bits (327), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 44/116 (37%), Positives = 58/116 (50%), Gaps = 1/116 (0%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
               + K  TF+AAH L   P       LHGHSF V   + G+     GW+ D A+L  A
Sbjct: 4   PVFEITKAATFDAAHYLAEGPAHRPYTNLHGHSFKVEATVRGQPQEPVGWVADLADLDEA 63

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGC 116
            K     LDH  LN+ PGLE PT E L  +  ++++P  P LS V+V + T    C
Sbjct: 64  LKAVAGELDHGLLNEKPGLERPTLEHLCLYFAERLRPRFPGLSRVVVSRPTIGESC 119


>UniRef50_C0GP47 Queuosine biosynthesis protein QueD n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GP47_9DELT
          Length = 128

 Score =  129 bits (325), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 46/126 (36%), Positives = 68/126 (53%), Gaps = 9/126 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKA 60
               L     F ++H+L +   G KC  LHGH+F V++++ G EVDP TG ++DF ELK 
Sbjct: 4   PRYCLRVSSDFSSSHQLRNY--GGKCESLHGHNFQVQVQVCGKEVDPDTGMLMDFKELKN 61

Query: 61  AFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTA 114
                 E LDH +LND+P  +  NP+SE LA +++  +K  +      L  VMV E  ++
Sbjct: 62  TLLAVLEELDHKHLNDLPHFKETNPSSENLACFVYQGLKKSLGNRGVYLDWVMVAEKDSS 121

Query: 115 GCIYRG 120
              Y  
Sbjct: 122 RAYYSE 127


>UniRef50_B5Y6S0 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Bacteria
           RepID=B5Y6S0_COPPD
          Length = 127

 Score =  129 bits (324), Expect = 4e-29,   Method: Composition-based stats.
 Identities = 42/126 (33%), Positives = 71/126 (56%), Gaps = 10/126 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-HTGWIIDFAELKA 60
           M+  + K FTF+AAH L +     KC  LHGH++ + + + G  +    G ++DF +LK 
Sbjct: 1   MNVCVTKAFTFDAAHNLTNYK--GKCEALHGHTYRLEVTVCGTPNELENGLLMDFGDLKD 58

Query: 61  AF-KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAG 115
              K    +LDH YLND    E P++E++A W+++ +KP V     +L++V + ET T+ 
Sbjct: 59  LVNKEVLSKLDHSYLNDH--FEQPSTELVAMWVFETLKPHVEKLGLVLTSVKLFETATSW 116

Query: 116 CIYRGE 121
              + +
Sbjct: 117 VEIKAD 122


>UniRef50_A9AWJ6 Putative uncharacterized protein n=1 Tax=Herpetosiphon aurantiacus
           ATCC 23779 RepID=A9AWJ6_HERA2
          Length = 133

 Score =  128 bits (323), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 13/126 (10%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-----HTGWIIDFA 56
           M   L K F FEAAH+LP+     KC RLHGHS+++ + + G + P       G +ID  
Sbjct: 1   MYAILTKQFRFEAAHQLPN--HRGKCARLHGHSYLLEVSVRGLIQPTRGQSDDGMVIDLE 58

Query: 57  ELKAAFKP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKET 111
           ++K         R+DH+ LND   + + T+E +A W+WDQ++   P     L  + + ET
Sbjct: 59  QIKQLVNEIIIARVDHYNLNDFLSVPS-TAENIAHWMWDQLEQQAPEFAALLWRIRLWET 117

Query: 112 CTAGCI 117
            +    
Sbjct: 118 ASGYVE 123


>UniRef50_Q90W95 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Deuterostomia
           RepID=PTPS_POERE
          Length = 147

 Score =  127 bits (320), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 16/133 (12%)

Query: 5   TLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIID 54
            + +  +F A HRL         +     KC     HGH++ V + + G++DP TG +++
Sbjct: 15  YITRVQSFSACHRLHSLRLSDEENKEVYGKCNNPYGHGHNYKVEVTVRGKIDPVTGMVMN 74

Query: 55  FAELKAAFKPTYE-RLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMV 108
             +LK   +      LDH  L+ D+P   +   T+E LA +IWD +   +P      + +
Sbjct: 75  LTDLKKCIEEVIMIPLDHKNLDKDVPYFADVVSTTENLAVYIWDNMAKALPASLPYEIRI 134

Query: 109 KETCTAGCIYRGE 121
            ET     +YRGE
Sbjct: 135 HETDKNIVVYRGE 147


>UniRef50_D0J5V8 6-pyruvoyl tetrahydropterin synthase and n=7 Tax=Comamonadaceae
           RepID=D0J5V8_COMTE
          Length = 121

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 38/117 (32%), Positives = 64/117 (54%), Gaps = 1/117 (0%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M  T+ + F F+AAH L    E     R+HGH++   + + G  +P  G +ID   L+A 
Sbjct: 1   MQFTVHQRFFFDAAHTLERAIETESSRRIHGHTYWAEVSVRGPRNPDNGMVIDLGHLRAR 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK-ETCTAGCI 117
            +   ++LDHH+L+++PGL  PT E L  +I + +  + P  S + V  ++   GC+
Sbjct: 61  LELLRDQLDHHFLDEVPGLGKPTLENLCLFIANALADLEPAPSRIRVWRDSIGDGCV 117


>UniRef50_C1TQH0 PreQ(0) biosynthesis protein QueD n=2 Tax=Bacteria
           RepID=C1TQH0_9BACT
          Length = 139

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 43/117 (36%), Positives = 62/117 (52%), Gaps = 10/117 (8%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP- 64
           L K+FTF+AAHRL       KC  LHGH++ + + + G  D     + DF ELK      
Sbjct: 21  LRKEFTFDAAHRLERY--RGKCEALHGHTYRLAVTLNGRSDDED-MVFDFTELKRIVSEK 77

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCI 117
               LDH YLND+  ++ PT+E +A W+W ++   V      L +V + ET T+  I
Sbjct: 78  ILTELDHAYLNDV--MDQPTAENIALWVWRKLDESVKRPNCELHSVQIWETATSSVI 132


>UniRef50_C8VWH9 Putative uncharacterized protein n=1 Tax=Desulfotomaculum
           acetoxidans DSM 771 RepID=C8VWH9_DESAS
          Length = 125

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 41/121 (33%), Positives = 59/121 (48%), Gaps = 8/121 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L     F++AH L   P   KC  +HGH++ + + + GE    TG +IDF+ELK   K
Sbjct: 5   FELKVTEHFDSAHYLREYP--GKCKNVHGHTWYIEVVLQGENLDSTGILIDFSELKGLIK 62

Query: 64  PTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCI 117
              E  DH  LN+    E  NPTSE LA++ + ++K  +      L  V V E+      
Sbjct: 63  NIIEPFDHQLLNEQVPFEVDNPTSENLARYFYHEIKKKLSDKPVKLVRVTVSESRATAAA 122

Query: 118 Y 118
           Y
Sbjct: 123 Y 123


>UniRef50_A1HNF1 Putative uncharacterized protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HNF1_9FIRM
          Length = 130

 Score =  126 bits (317), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 14/127 (11%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT------GEVDPHTGWIIDF 55
            +    K FTF+AAH LP      KC ++HGH++ + + +           P  G +IDF
Sbjct: 4   PTVRTTKIFTFDAAHFLPGHE--GKCAQMHGHTYRLEVTVERKDGGVATGGPEDGMVIDF 61

Query: 56  AELKAAFKP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKE 110
             L A  K    ++LDH  LND      PTSE +A+ I+ ++  ++      +  V++ E
Sbjct: 62  GRLSALIKDRVVDKLDHKVLNDCFPFR-PTSENMARHIFIELSAILANEDVNVVRVVLWE 120

Query: 111 TCTAGCI 117
           T T+   
Sbjct: 121 TPTSYVE 127


>UniRef50_B5W8I5 Putative uncharacterized protein n=3 Tax=Cyanobacteria
           RepID=B5W8I5_SPIMA
          Length = 130

 Score =  126 bits (317), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 49/131 (37%), Positives = 67/131 (51%), Gaps = 12/131 (9%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT------GEVDPHTGWIID 54
           M    L  +FTF++AH +        CGRLHGH++ VR+E T       E  PH   + D
Sbjct: 1   MSKWKLTTEFTFDSAHYIKDY--NGPCGRLHGHTYKVRVEATSNQLHGSEFCPHPVMVAD 58

Query: 55  FAELKAAFKPTYE-RLDHHYLNDI-PGLENPTSEVLAKWIWDQVKPVVPL--LSAVMVKE 110
           F  L+ A K   +  LDH  LN+I P     T+E++AK+I+D+ K  VP      VMV E
Sbjct: 59  FRSLRWAKKDVSKGGLDHGLLNEILPPNYETTAEMIAKFIYDETKKRVPEGVQLKVMVSE 118

Query: 111 TCTAGCIYRGE 121
           T  +   Y  E
Sbjct: 119 TANSWVEYEDE 129


>UniRef50_B0TFF5 6-pyruvoyl-tetrahydropterin synthase, putative n=2
           Tax=Clostridiales RepID=B0TFF5_HELMI
          Length = 130

 Score =  125 bits (316), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 36/127 (28%), Positives = 59/127 (46%), Gaps = 10/127 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F+AAH L   P    C R+HGH++ V + + G      G +IDF E+K A 
Sbjct: 1   MYELIVQTHFDAAHYLRDYP--GDCARVHGHTWQVEVTLVGRQLDDLGMLIDFKEVKKAV 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP------LLSAVMVKETCTA 114
           K   ++LDH  +N+       NPT+E L+ + + ++   +        +  V + E+  A
Sbjct: 59  KAICDQLDHRMINEHDYFLQRNPTAENLSCYFFHELAGWLKENHPHVRVGTVRIWESPRA 118

Query: 115 GCIYRGE 121
              YR +
Sbjct: 119 SICYRAD 125


>UniRef50_A3UD70 6-pyruvoyl tetrahydrobiopterin synthase, putative n=1
           Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UD70_9RHOB
          Length = 132

 Score =  125 bits (316), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 43/118 (36%), Positives = 69/118 (58%), Gaps = 1/118 (0%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + KDFTF+AAH   H    H   R+HGHSF   + +TG     +G + DF E++A  
Sbjct: 13  HLEISKDFTFDAAHHFEHKDANHPFSRMHGHSFAGTVTLTGSRAAESGMVKDFWEIEAEI 72

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKE-TCTAGCIYR 119
               E+LDH  LND+ GLE+P+ E +A W++++++  +P L+AV ++  +C    + R
Sbjct: 73  NKIREQLDHRLLNDVEGLEHPSLEAIAYWVFERLEKTLPGLTAVEIRRPSCGEKAVVR 130


>UniRef50_Q3ZW85 6-pyruvoyl tetrahydrobiopterin synthase n=5 Tax=Dehalococcoides
           RepID=Q3ZW85_DEHSC
          Length = 123

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 39/123 (31%), Positives = 57/123 (46%), Gaps = 8/123 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     FEAAH L       KC  LHGH + V L++        G   DF+ LK   
Sbjct: 1   MYYLSVKKHFEAAHFLRGYK--GKCENLHGHRYEVALKVKTGELDECGMGADFSLLKTRL 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
               +  DH  LND+   +  NP++E +AK I+D++K V+      L  V V E+  +  
Sbjct: 59  NEVLQSYDHTCLNDLTPFDNINPSAENIAKDIYDKLKTVINKKGVELWGVEVWESPDSSV 118

Query: 117 IYR 119
           +Y+
Sbjct: 119 LYQ 121


>UniRef50_B8FMW4 Queuosine biosynthesis protein QueD n=3 Tax=Proteobacteria
           RepID=B8FMW4_DESAA
          Length = 126

 Score =  124 bits (313), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 41/124 (33%), Positives = 59/124 (47%), Gaps = 8/124 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++    F AAH L        C R+HGH++MV + I        G  IDF ++K A +
Sbjct: 5   FEIYVKTHFSAAHALTGYD--GDCSRIHGHNWMVEVSIQCRKLDDVGIGIDFKDVKDAVE 62

Query: 64  PTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCI 117
              + LDH  LND P  +  NPTSE +A +++ Q+   +      +S V V E   AG  
Sbjct: 63  EITQGLDHCMLNDHPAFQSVNPTSENVAMFLYKQLGSHLNNEYTKVSRVKVFEAPGAGAA 122

Query: 118 YRGE 121
           Y  E
Sbjct: 123 YWEE 126


>UniRef50_P48611 6-pyruvoyl tetrahydrobiopterin synthase n=16 Tax=Eumetazoa
           RepID=PTPS_DROME
          Length = 168

 Score =  124 bits (312), Expect = 8e-28,   Method: Composition-based stats.
 Identities = 43/132 (32%), Positives = 64/132 (48%), Gaps = 17/132 (12%)

Query: 6   LFKDFTFEAAHRL--------PHVPEGHKCGRLHGH--SFMVRLEITGEVDPHTGWIIDF 55
           L +  TF A HRL         ++    KC   HGH  ++ V + + G +D  TG +++ 
Sbjct: 9   LTRRETFSACHRLHSPQLSDAENLEVFGKCNNFHGHGHNYTVEITVRGPIDRRTGMVLNI 68

Query: 56  AELKAAFKPTY-ERLDHHYLN-DIPGLENP--TSEVLAKWIWDQVKPVVP---LLSAVMV 108
            ELK A +    +RLDH  L+ D+    N   T+E LA +IWD ++  +    LL  V +
Sbjct: 69  TELKEAIETVIMKRLDHKNLDKDVEYFANTPSTTENLAVYIWDNIRLQLKKPELLYEVKI 128

Query: 109 KETCTAGCIYRG 120
            ET      YRG
Sbjct: 129 HETPKNIISYRG 140


>UniRef50_A0M3Y1 Conserved tetrahydrobiopterin biosynthesis-like protein n=22
           Tax=Bacteroidetes RepID=A0M3Y1_GRAFK
          Length = 136

 Score =  124 bits (312), Expect = 9e-28,   Method: Composition-based stats.
 Identities = 42/136 (30%), Positives = 65/136 (47%), Gaps = 16/136 (11%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRLH--GHSFMVRLEITGEVDPHTGW 51
           M  T+ +   F AAHRL         +     KC   H  GH++ + + +TGE DP TG+
Sbjct: 1   MRITVHRKAHFNAAHRLYRKDWDDERNFGVFGKCSNPHYHGHNYELIVSVTGEPDPETGF 60

Query: 52  IIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLS--A 105
           ++D   LK        E  DH  LN ++P  E+  PT+E +A  IW++++  +       
Sbjct: 61  VMDLKILKELIYLEVEEAFDHKNLNVEVPEFEDLIPTAEHIAVVIWNKLRTRIQEDHDLK 120

Query: 106 VMVKETCTAGCIYRGE 121
           V + ET      Y+GE
Sbjct: 121 VTLYETPRNFVSYKGE 136


>UniRef50_Q3A420 6-pyruvoyl-tetrahydropterin synthase n=7 Tax=Bacteria
           RepID=Q3A420_PELCD
          Length = 122

 Score =  124 bits (312), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 33/113 (29%), Positives = 55/113 (48%), Gaps = 7/113 (6%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
            F AAH L +      C  LHGH++ V + +        G  +DF  LK       + LD
Sbjct: 9   HFAAAHNLMNYQ--GDCENLHGHNWKVEVTVATRELDKAGLGVDFKILKKETNRILDLLD 66

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL---LSAVMVKETCTAGCIY 118
           H YLND+P  +  +P+SE +A+++++++  V      +  V + E+  A   Y
Sbjct: 67  HKYLNDLPFFKGISPSSENIARFVFEELSKVFQESVVVENVRIWESDNACASY 119


>UniRef50_A6LBJ5 6-pyruvoyl-tetrahydropterin synthase n=43 Tax=Bacteria
           RepID=A6LBJ5_PARD8
          Length = 110

 Score =  124 bits (312), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 38/119 (31%), Positives = 59/119 (49%), Gaps = 9/119 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T+ K     A+H L  +    KC  LHGH++M+ +    +     G ++DF+ +K + 
Sbjct: 1   MYTVIKRMEISASHSLR-LSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSV 59

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
           K     LDH  LNDI    NPT+E +A W+++Q    +P    V VKE+     IY  +
Sbjct: 60  KSL---LDHQNLNDILPF-NPTAENIAFWVYEQ----IPSCFKVEVKESEGNTAIYEED 110


>UniRef50_D2L9S0 Putative uncharacterized protein n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9S0_9DELT
          Length = 124

 Score =  124 bits (311), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 44/122 (36%), Positives = 63/122 (51%), Gaps = 7/122 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
            T+     F AAHRLP  P    C  +HGH+F V + +T       G + DF +++AA  
Sbjct: 5   YTITVSGAFSAAHRLPDHP--GPCAFMHGHNFEVAVALTATALVR-GMVADFLDVRAALD 61

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYR 119
             + RLDH  LNDIP L  PT+EVLA WI+ Q++  +      ++ V V E+      Y 
Sbjct: 62  AAFARLDHACLNDIPELSPPTAEVLAAWIFGQLRERLDDGRVRVARVTVTESAGLAATYA 121

Query: 120 GE 121
            +
Sbjct: 122 ED 123


>UniRef50_A2SD50 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=5
           Tax=Proteobacteria RepID=A2SD50_METPP
          Length = 129

 Score =  124 bits (311), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 42/121 (34%), Positives = 72/121 (59%), Gaps = 4/121 (3%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKC---GRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
              L + F FE+AH L    E ++     R+HGH++   + + GE DP TG ++D A L+
Sbjct: 1   MFELSQSFYFESAHTLRRQVERNEADGSRRVHGHTYTAEVTVRGEADPATGMVVDLALLR 60

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIY 118
           +A     E+LDHH+L+++PGL  PT E L ++I +++   VP +++V V +++    C +
Sbjct: 61  SAIATVREQLDHHFLDEVPGLGLPTLENLCRFIHERLLTTVPAIASVSVGRQSSGDRCTF 120

Query: 119 R 119
           R
Sbjct: 121 R 121


>UniRef50_C0QLV0 PtpS n=8 Tax=cellular organisms RepID=C0QLV0_DESAH
          Length = 127

 Score =  124 bits (311), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 39/124 (31%), Positives = 61/124 (49%), Gaps = 10/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F AAH+L  V  G KC  LHGH++ V + + GE     G ++DF  +K   
Sbjct: 1   MFELKVKTHFAAAHKLAMV--GEKCENLHGHNWDVEVYVAGEQLNEAGVLVDFGVIKGFV 58

Query: 63  KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPL------LSAVMVKETCTA 114
           +   + LDH YLN++    +  P+SE +A +I +++KP +        +S V   E+  A
Sbjct: 59  RKIMKELDHKYLNELDAFADVQPSSEQIAIYIANRLKPSLKGFHPPVRVSRVSAWESANA 118

Query: 115 GCIY 118
              Y
Sbjct: 119 CATY 122


>UniRef50_B8J0W0 Queuosine biosynthesis protein QueD n=8 Tax=Desulfovibrionales
           RepID=B8J0W0_DESDA
          Length = 135

 Score =  123 bits (310), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 43/128 (33%), Positives = 59/128 (46%), Gaps = 15/128 (11%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKAAF 62
             L     F A H L H     KC R+HGH+F V L + G  + P T  ++DF  LK A 
Sbjct: 6   WRLTVRDDFSAGHALRHYE--GKCERMHGHNFAVELTVEGNRLAPQTEMLLDFKILKKAL 63

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----------LLSAVMVKE 110
           K   + LDH  LN+ P  +  NP+SE LA+ IW  ++ ++            L +V V E
Sbjct: 64  KAVLDALDHRLLNETPPFDRINPSSENLARHIWQGMEALLAEHEDPQARLVRLHSVTVSE 123

Query: 111 TCTAGCIY 118
                  Y
Sbjct: 124 KGAQSATY 131


>UniRef50_C1A6G1 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1A6G1_GEMAT
          Length = 137

 Score =  123 bits (310), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 16/137 (11%)

Query: 1   MMSTTLFKDFTFEAAHRLPH--------VPEGHKCGR--LHGHSFMVRLEITGEVDPHTG 50
           M   T+ +   F AAHR+ +             KC     HGH++ + + + G V   TG
Sbjct: 1   MPIVTVTRRLRFNAAHRVHNPALSDADNTRLFGKCNNPNWHGHNYTLDVSVRGPVAEDTG 60

Query: 51  WIIDFAELKAAF-KPTYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVV--PLLS 104
           ++ID   L+A   +    + DH   N D+P ++  NPT+E +   +W  + P +    L 
Sbjct: 61  YVIDLGALRAIVEREVLSQTDHRNFNIDVPYMQGINPTTENIVVAMWQVLGPAIAPATLQ 120

Query: 105 AVMVKETCTAGCIYRGE 121
            + + ET      Y GE
Sbjct: 121 RLRLWETENNYVDYSGE 137


>UniRef50_B1ZTR4 Putative uncharacterized protein n=3 Tax=Bacteria
           RepID=B1ZTR4_OPITP
          Length = 161

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 44/131 (33%), Positives = 64/131 (48%), Gaps = 16/131 (12%)

Query: 6   LFKDFTFEAAHRLPH--------VPEGHKCG--RLHGHSFMVRLEITGEVDPHTGWIIDF 55
           + +   F AAHRL +          +   C     HGH++++ + + GE DP TG+I+D 
Sbjct: 24  ITRQVHFNAAHRLYNPTKSQAWNTNQYGLCTSPNWHGHNYVLEVTVRGEPDPETGYIVDL 83

Query: 56  AELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMVK 109
           +ELK        +R DH  LN D+  L N  PT+E L    WDQ++P +P   L  V + 
Sbjct: 84  SELKRVLHETVVDRCDHRNLNDDVDFLRNVIPTTENLVIAFWDQIEPALPAGKLHCVRLY 143

Query: 110 ETCTAGCIYRG 120
           ET      Y G
Sbjct: 144 ETPRNFAEYFG 154


>UniRef50_B9EM09 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=Coelomata
           RepID=B9EM09_SALSA
          Length = 204

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 17/133 (12%)

Query: 5   TLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIID 54
            + +  +F A HRL         +     KC     HGH++   + + G++D HTG +++
Sbjct: 73  YITRVQSFSACHRLHSPTLSDEVNKRIFGKCNNPNGHGHNYK-EVTVRGKIDRHTGMVMN 131

Query: 55  FAELKAAFKPTYE-RLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMV 108
             +LK   +      LDH  L+ D+P   N   T+E +A +IWD +   +P   L  V +
Sbjct: 132 ITDLKQHIEEVIMIPLDHKNLDKDVPYFANVVSTTENVAVYIWDNMVKQLPANLLYEVKI 191

Query: 109 KETCTAGCIYRGE 121
            ET     +YRGE
Sbjct: 192 HETDKNIVVYRGE 204


>UniRef50_D1B660 Putative uncharacterized protein n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B660_THEAS
          Length = 121

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 42/120 (35%), Positives = 63/120 (52%), Gaps = 10/120 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L + F+F AAH LP      +C  LHGH++   + + G  DP  G I+DF ELK   +
Sbjct: 1   MKLKRRFSFSAAHWLPRYK--GRCEALHGHTYSFVITLEGSPDPE-GMIMDFTELKGLVE 57

Query: 64  P-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIY 118
                RLDH  LND+  LE PT+E L++WI++ +   +      L +V V E+     ++
Sbjct: 58  EMVLSRLDHSCLNDL--LEQPTAEALSRWIFEALADRLEAPNRRLESVEVFESPDCSALF 115


>UniRef50_Q8Z0L1 Alr0080 protein n=5 Tax=Cyanobacteria RepID=Q8Z0L1_ANASP
          Length = 128

 Score =  122 bits (307), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 40/129 (31%), Positives = 65/129 (50%), Gaps = 12/129 (9%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEI------TGEVDPHTGWIID 54
           M    +  +F+F +AH +        CGR+HGH++ VR+E       + +  PH   + D
Sbjct: 1   MPKWKVVTEFSFNSAHYIKDY--NGPCGRMHGHNYQVRIEAISTQLHSSQYCPHPVMVAD 58

Query: 55  FAELKAAFKPTYE-RLDHHYLNDI-PGLENPTSEVLAKWIWDQVKPVVP--LLSAVMVKE 110
           F  L+ A +   +  LDH  LN++ P     T+E++AK+I+D+ K  VP  +   V V E
Sbjct: 59  FRTLRWAKQDVTKGGLDHGILNEVMPPEYETTAEMIAKYIYDETKKRVPPDVQLKVNVSE 118

Query: 111 TCTAGCIYR 119
           T  +   Y 
Sbjct: 119 TPNSWVEYE 127


>UniRef50_B1GYR9 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GYR9_UNCTG
          Length = 122

 Score =  122 bits (306), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 7/121 (5%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L    +F +AH L       +C  LHGH++ +R    G     TG +IDF ++K  
Sbjct: 1   MKYKLSVTRSFSSAHCLREYK--GRCENLHGHNWKIRAAFYGTELDDTGVLIDFMDIKMH 58

Query: 62  FKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKP---VVPLLSAVMVKETCTAGC 116
                  LDH +LN+I   +  NPT+E +A +I  ++K        +  V + E+ ++  
Sbjct: 59  LNKVINYLDHKFLNEIVPFDRVNPTAENIAAFILGRLKDIETKNAKVCEVEIWESESSSA 118

Query: 117 I 117
           +
Sbjct: 119 V 119


>UniRef50_Q6ARY1 Related to 6-pyruvoyl tetrahydropterin synthase n=1
           Tax=Desulfotalea psychrophila RepID=Q6ARY1_DESPS
          Length = 136

 Score =  122 bits (306), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 16/132 (12%)

Query: 1   MMSTTLFKDFTFEAAHRL--------PHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWI 52
           M   T+ K+F F+AAH+L         +     KC +LHGH++ +R+ ITG+V P  G +
Sbjct: 1   MAMLTITKEFRFDAAHKLFLKDLTDQENREAFGKCSQLHGHTYCLRITITGKVQP-NGMV 59

Query: 53  IDFAELKAAFKP-TYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP----LLSA 105
           ++F +LK   +     R DH +LN++    +   T+E ++ +I+  +   +      L+ 
Sbjct: 60  LNFTDLKQIVEEKIIARYDHSHLNELEEYRDLPTTAENMSLYIFKVLAACLKKQKVTLTE 119

Query: 106 VMVKETCTAGCI 117
           V + ET T+   
Sbjct: 120 VQLYETPTSWAT 131


>UniRef50_C7HJ58 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Clostridia
           RepID=C7HJ58_CLOTM
          Length = 127

 Score =  122 bits (306), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 37/120 (30%), Positives = 64/120 (53%), Gaps = 9/120 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             ++ K FTF++AH L       KC  +HGH++ + + + G  D   G ++DF +L+A  
Sbjct: 5   KVSITKLFTFDSAHHLIDY--NGKCRNIHGHTYKLEITLKGLPD-ENGLVMDFHDLEAII 61

Query: 63  -KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCI 117
                E++DH YLND+    NPT E++  W+W+++   V      L  +++ ET T+   
Sbjct: 62  ENEVLEKVDHKYLNDVFDF-NPTCEMIGLWLWEEISKQVQNTRCTLEKLVLWETPTSYIT 120


>UniRef50_B8DNN3 Putative uncharacterized protein n=3 Tax=Desulfovibrio
           RepID=B8DNN3_DESVM
          Length = 130

 Score =  121 bits (305), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 39/122 (31%), Positives = 55/122 (45%), Gaps = 9/122 (7%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAF 62
             L     F A+H L H     KC  +HGH+F V +   G+     T  ++DF  LK   
Sbjct: 6   WRLTVRSEFCASHALRHYE--GKCESMHGHNFAVEMVAEGDRLTGDTEIVLDFKVLKREL 63

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
               + LDH  LND+   +  NP+SE L++ IW Q+ P +      L +V V E      
Sbjct: 64  NAVLDTLDHKNLNDVTPFDTINPSSENLSRHIWQQLAPRLAPHGVRLHSVTVSEKAAQSA 123

Query: 117 IY 118
            Y
Sbjct: 124 TY 125


>UniRef50_C7QN33 6-pyruvoyltetrahydropterin synthase n=3 Tax=Cyanobacteria
           RepID=C7QN33_CYAP0
          Length = 291

 Score =  121 bits (305), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 42/134 (31%), Positives = 62/134 (46%), Gaps = 18/134 (13%)

Query: 2   MSTTLFKDFTFEAAHRLP--------HVPEGHKCGRLHGH--SFMVRLEITGEVDPHTGW 51
           M  TL     F AAHRL         +     KC R+HGH  ++ + + +TGE+DP TG 
Sbjct: 134 MKATLTIQTHFSAAHRLALPELTLEQNSEIYGKCARIHGHGHNYHLEVSVTGEIDPRTGM 193

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV----PLL 103
           ++D   L+   K    E  DH +LN DIP      PT+E +A +I   ++  +      L
Sbjct: 194 LVDLGILQQVVKDYVVEPFDHTFLNKDIPYFAQVVPTAENIALYIAQLLQTPIQQLGAEL 253

Query: 104 SAVMVKETCTAGCI 117
             V + E+    C 
Sbjct: 254 DKVKLIESPNNSCE 267



 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 37/133 (27%), Positives = 66/133 (49%), Gaps = 16/133 (12%)

Query: 2   MSTTLFKDFTFEAAHR--LPHVPE------GHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   + +   F A+HR  L  + E         C R   HGH++++ + + GE+D + G 
Sbjct: 1   MQCVINRRAQFSASHRYWLSELDEQENRLKFGDCTRFPGHGHNYVLYVSLLGEIDSY-GM 59

Query: 52  IIDFAELKAAFKP-TYERLDHHYLNDI-PGLEN--PTSEVLAKWIWDQVKPVVPLLSAVM 107
           + + + +K   K     +LD+ YLND+    ++  PT+E LA+ IW ++ P +P L  + 
Sbjct: 60  VENLSTVKRVIKEEITSQLDYCYLNDVWEEFQDSLPTTENLARVIWQRLAPHLP-LVNIQ 118

Query: 108 VKETCTAGCIYRG 120
           + E       Y+G
Sbjct: 119 LFEHPQLWADYQG 131


>UniRef50_B0SX52 Queuosine biosynthesis protein QueD n=1 Tax=Caulobacter sp. K31
           RepID=B0SX52_CAUSK
          Length = 121

 Score =  121 bits (305), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 43/114 (37%), Positives = 58/114 (50%), Gaps = 2/114 (1%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K  TF+AAH +   P  H+  +LHGHSF V   + G      GW+ D   L  A K
Sbjct: 5   FEITKAATFDAAHYIEQGPPDHRYRKLHGHSFKVEASVRG-ALQEAGWVADLDSLDGALK 63

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGC 116
                LDH  LND PGLE+PT E L  +  +++ P  P LS V++ + T    C
Sbjct: 64  AVAAELDHGLLNDRPGLESPTLERLCLYFAERLTPRFPGLSRVVISRPTIGESC 117


>UniRef50_Q1ZXI0 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Eukaryota
           RepID=PTPS_DICDI
          Length = 135

 Score =  121 bits (305), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 42/131 (32%), Positives = 64/131 (48%), Gaps = 13/131 (9%)

Query: 4   TTLFKDFTFEAAHRL--------PHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDF 55
             L +   F ++HRL         +     KC   HGH++++ + I G V    G  ++ 
Sbjct: 5   VILTRREVFSSSHRLYSDKLSLEENKKIYGKCINSHGHNYVLEVSIKGAVKEDIGMFMNI 64

Query: 56  AELKAAFKP-TYERLDHHYL-NDIPGLEN--PTSEVLAKWIWDQVKPVVPL-LSAVMVKE 110
            ELK   K    ++LDH  L ND+P L+    T+E L+ +IWDQ+ P +   L  V + E
Sbjct: 65  TELKEILKEKVMDKLDHKNLENDVPELKGIVTTTENLSIFIWDQLFPSLKDFLYEVKILE 124

Query: 111 TCTAGCIYRGE 121
           T     +YRGE
Sbjct: 125 TENNFVVYRGE 135


>UniRef50_D0Y1P4 6-pyruvoyl tetrahydropterin synthase n=3 Tax=cellular organisms
           RepID=D0Y1P4_9CAUL
          Length = 121

 Score =  121 bits (304), Expect = 8e-27,   Method: Composition-based stats.
 Identities = 45/117 (38%), Positives = 60/117 (51%), Gaps = 2/117 (1%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
               + K   F+AAH +   P  H+  +LHGHSF V   + GE+ P  GW+ D   L AA
Sbjct: 3   PVFEITKAAYFDAAHYIEQGPADHRYRKLHGHSFKVEASVKGEMAP-AGWVADLDSLDAA 61

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCI 117
            K     LDH  LND PGLE PT E L  +  +++K   P LS V + + T    C+
Sbjct: 62  LKAVAAELDHGLLNDKPGLETPTLERLCLYFAERLKVQFPGLSRVELSRPTIGERCV 118


>UniRef50_C6VZC4 Putative uncharacterized protein n=3 Tax=Sphingobacteriales
           RepID=C6VZC4_DYAFD
          Length = 138

 Score =  120 bits (301), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 39/134 (29%), Positives = 65/134 (48%), Gaps = 16/134 (11%)

Query: 1   MMSTTLFKDFTFEAAHRLPH--------VPEGHKCGRL--HGHSFMVRLEITGEVDPHTG 50
           + +  +F+   F AAHRL +             KC     HGH++ + +++TG +DP TG
Sbjct: 2   VQNVAVFRKEHFNAAHRLHNPAWSDEQNEAVFGKCNNPSFHGHNYELIVQVTGPLDPETG 61

Query: 51  WIIDFAELKAAFKP-TYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVV-PLLS- 104
           +++D   L A  K    +R DH  LN D+   +  NPT+E +A  I+  ++P +   L  
Sbjct: 62  YVMDMKLLSAILKESVIDRFDHRNLNLDVEEFKTLNPTAENIAIVIYSIIRPKIDAGLDL 121

Query: 105 AVMVKETCTAGCIY 118
            + + ET      Y
Sbjct: 122 KIRLYETERNFVEY 135


>UniRef50_Q6B324 6-pyruvoyl tetrahydropterin synthase (Fragment) n=6 Tax=Eumetazoa
           RepID=Q6B324_DANRE
          Length = 143

 Score =  120 bits (301), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 16/130 (12%)

Query: 6   LFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           + +  +F A HRL         +     KC     HGH++ V + + G++D +TG +++ 
Sbjct: 14  ITRVCSFSACHRLHSKCLSDEENKRTFGKCNNPNGHGHNYTVEVTVRGKIDKNTGMVMNL 73

Query: 56  AELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMVK 109
            +LK   +    + LDH  L+ D+P   +   T+E L+ +IWD ++ ++P   L  + V 
Sbjct: 74  TDLKEFIEEAVMKPLDHKNLDLDVPYFADVVSTTENLSVFIWDGLQKLLPHDSLYEIKVY 133

Query: 110 ETCTAGCIYR 119
           ET     IYR
Sbjct: 134 ETAKNIVIYR 143


>UniRef50_A2BZT2 6-pyruvoyl tetrahydropterin synthase n=48 Tax=cellular organisms
           RepID=A2BZT2_PROM1
          Length = 308

 Score =  118 bits (297), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 18/134 (13%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L     F AAHRL         +     KC R   HGH+++V + + G+++P TG 
Sbjct: 152 MDAYLTVQTHFSAAHRLAREDLPQTENEKIFGKCARPNGHGHNYLVDITVKGKINPRTGM 211

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV----PLL 103
           I D + L +       E  DH +LN DIP   N  PT+E +A  I D++   +      L
Sbjct: 212 ICDLSALNSLINDLVVEPFDHTFLNKDIPYFANCVPTAENIALHISDKLTNPINAIGANL 271

Query: 104 SAVMVKETCTAGCI 117
             + ++E+      
Sbjct: 272 YKIKLQESPNNAAE 285



 Score = 98.2 bits (244), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 33/136 (24%), Positives = 63/136 (46%), Gaps = 21/136 (15%)

Query: 4   TTLFKDFTFEAAH--RLPHVPEG------HKCG--RLHGHSFMVRLEITGEVDPHTGWII 53
             + +   F A+H  RLP + +         C     HGH++ + + + G+     G ++
Sbjct: 16  CVITRRACFSASHLYRLPELSDDDNSALFGPCSIAPGHGHNYELIVTMEGD-LNKYGMVL 74

Query: 54  DFAELKAAFK-PTYERLDHHYLNDI-PGLE-------NPTSEVLAKWIWDQVKPVVPLLS 104
           + +++K A K     +LD  +LND  P  +        PT+E L + IW+++K  +P L 
Sbjct: 75  NLSDVKYAIKNEVTSQLDFRFLNDTWPEFDLSKPEGCLPTTESLVRIIWERLKSHLP-LK 133

Query: 105 AVMVKETCTAGCIYRG 120
           ++ + E       Y+G
Sbjct: 134 SLRLYENPKLWADYQG 149


>UniRef50_Q30ZA2 6-pyruvoyl tetrahydrobiopterin synthase, putative n=3
           Tax=Desulfovibrionales RepID=Q30ZA2_DESDG
          Length = 130

 Score =  118 bits (297), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 42/122 (34%), Positives = 58/122 (47%), Gaps = 9/122 (7%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAF 62
             L     F AAH L +     KC  LHGH+F V   + G +  P T  ++DF  LK A 
Sbjct: 6   WRLTVRSDFAAAHSLRNY--CGKCEALHGHNFGVEATVEGGILTPDTELLVDFKVLKNAL 63

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
           K   + LDH  LN+ P  +  NP+SE LA+ I+  + P+V      + +V V E      
Sbjct: 64  KQVLDGLDHCVLNETPPFDTCNPSSENLARHIYRHMAPLVQPHGVRMHSVTVSEKQAQSA 123

Query: 117 IY 118
            Y
Sbjct: 124 TY 125


>UniRef50_Q3J9J8 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Chromatiales
           RepID=Q3J9J8_NITOC
          Length = 99

 Score =  118 bits (296), Expect = 6e-26,   Method: Composition-based stats.
 Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 6/98 (6%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLE--NPTSEV 87
           +HGH++ + +E+T +     G ++DF ++K + +    +LDH YLNDI   +  NPT+E 
Sbjct: 1   MHGHNWKLEVEVTAQALDQQGMVMDFKDIKESARELCAQLDHRYLNDISPFDLINPTAEN 60

Query: 88  LAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYRGE 121
           LA + +  +   +      +SA+ + ET  A   Y  +
Sbjct: 61  LAAFFYRGLSKQLNNERARVSAITLWETERACVRYTED 98


>UniRef50_C1DVU3 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=Aquificales
           RepID=C1DVU3_SULAA
          Length = 115

 Score =  117 bits (295), Expect = 8e-26,   Method: Composition-based stats.
 Identities = 40/110 (36%), Positives = 55/110 (50%), Gaps = 5/110 (4%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   +     F AAH L       K   LHGH++MV L I  +   + G   DF E+K  
Sbjct: 1   MPYIVRVKQKFNAAHFLTDY--HGKPEPLHGHTWMVELYIKADKLDNGGMGYDFLEIKDL 58

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKET 111
            K      D+  +NDI    +P++E +AK+I+DQVK   P L  V+V ET
Sbjct: 59  LKEILP--DYKCMNDIYDF-SPSAENVAKYIYDQVKKKYPTLVKVVVWET 105


>UniRef50_O31676 6-carboxy-5,6,7,8-tetrahydropterin synthase n=85 Tax=Bacillales
           RepID=QUED_BACSU
          Length = 146

 Score =  117 bits (293), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 43/129 (33%), Positives = 65/129 (50%), Gaps = 16/129 (12%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  L KD    AAH +P    G  C R+HGH++ V + + G+    +G++++F+ LK   
Sbjct: 14  SFELNKDMHISAAHFIPRESAGA-CSRVHGHTYTVNITVAGDELDDSGFLVNFSVLKKL- 71

Query: 63  KPTYERLDHHYLNDIPGLEN------PTSEVLAKWIWDQVKPVV------PLLSAVMVKE 110
              +   DH  LND            PT+EV+AK I+D V+  +      P    V V+E
Sbjct: 72  --VHGNYDHTLLNDHEDFSQDDRYSLPTTEVVAKTIYDNVQAYLDTLENKPTCVQVFVRE 129

Query: 111 TCTAGCIYR 119
           T T+ C+YR
Sbjct: 130 TPTSYCVYR 138


>UniRef50_C0N3T5 6-pyruvoyl tetrahydropterin synthase superfamily n=2
           Tax=Gammaproteobacteria RepID=C0N3T5_9GAMM
          Length = 98

 Score =  117 bits (293), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 6/98 (6%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLE--NPTSEV 87
           +HGH++ + +E+T       G  +DF  +K A +   + LDH YLNDIP  +  NPT+E 
Sbjct: 1   MHGHNWKLEVEVTATALNEHGMGMDFKTIKTAARELAKTLDHRYLNDIPPFDTVNPTAEN 60

Query: 88  LAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYRGE 121
           +A++ + ++   +      +S V + ET  A   Y  E
Sbjct: 61  IAQYFYQKLSGTLNNETAKISGVTLWETDRACVKYSEE 98


>UniRef50_Q3B4V1 6-pyruvoyltetrahydropterin synthase n=11 Tax=Chlorobiaceae
           RepID=Q3B4V1_PELLD
          Length = 162

 Score =  116 bits (291), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 48/140 (34%), Positives = 65/140 (46%), Gaps = 21/140 (15%)

Query: 3   STTLFKDFTFEAAHRL--PHVPEG------HKCGRL--HGHSFMVRLEITGEVDPHTGWI 52
              + +   F AAHRL  P   E        KC     HGH++ + + + G VDP TG++
Sbjct: 23  KVYVTRTIEFNAAHRLFNPKFSEEMNTRVYGKCANKYGHGHNYQLEITLGGTVDPETGYL 82

Query: 53  IDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL------ 102
            D  ELK    +    R DH +LN D+P LE   PT+E LA  IWD ++  +        
Sbjct: 83  FDLKELKKILEEEVTARFDHRHLNHDVPELEGLVPTTETLAVLIWDILEERIAAIDNREI 142

Query: 103 -LSAVMVKETCTAGCIYRGE 121
            L AV + ET      Y GE
Sbjct: 143 SLQAVKLHETGKNSVSYLGE 162


>UniRef50_D1NB55 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1NB55_9BACT
          Length = 123

 Score =  115 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  D +F AAH+L        C +LHGH++ + + +        G  +DF +LKA  
Sbjct: 1   MFEIEIDRSFSAAHQLRGY--NGDCCKLHGHNYKITVTVRSSELDEIGIALDFKKLKAEL 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
                  DH  L+++   +  NPTSE LA+ I+ ++   +      +  V V E+  +  
Sbjct: 59  DALLAEYDHSNLSELADFQAVNPTSENLARTIYRKISEKMNSGTIRVHRVRVGESDHSAV 118

Query: 117 IYRGE 121
            Y  +
Sbjct: 119 TYFED 123


>UniRef50_O02058 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=10
           Tax=Fungi/Metazoa group RepID=PTPS_CAEEL
          Length = 140

 Score =  115 bits (288), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 39/136 (28%), Positives = 70/136 (51%), Gaps = 16/136 (11%)

Query: 1   MMSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTG 50
           M   T+ +  +F AAHRL         +     KC     HGH+++ ++++ GEVDP +G
Sbjct: 4   MPIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSG 63

Query: 51  WIIDFAELKAAFKPTYERLDHHYLN-DIPGLENP--TSEVLAKWIWDQVKPVV---PLLS 104
            + D A+LK       + +DH  L+ D+   +    TSE +A ++++++K V+    +L 
Sbjct: 64  MVYDLAKLKKEMSLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMFEKLKSVMSNPSVLY 123

Query: 105 AVMVKETCTAGCIYRG 120
            V ++ET      Y+G
Sbjct: 124 KVTIEETPKNIFTYKG 139


>UniRef50_B2KC64 Putative uncharacterized protein n=1 Tax=Elusimicrobium minutum
           Pei191 RepID=B2KC64_ELUMP
          Length = 115

 Score =  114 bits (287), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 40/123 (32%), Positives = 59/123 (47%), Gaps = 13/123 (10%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L +   F +AHRLP      +C  LHGH+++V   I GE    +G + DF  LK  
Sbjct: 1   MLLKLKRK--FSSAHRLPDYD--GECNNLHGHTWVVEFIIEGET-KESGMVEDFKTLKPL 55

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCI 117
                   DH YLND   ++NPT+E + K+I+D    ++      L  V + E   A  I
Sbjct: 56  LDSVLP--DHKYLNDF--VQNPTAENMVKYIYDNAAKLLTQRGLKLKQVELWENENASAI 111

Query: 118 YRG 120
           ++ 
Sbjct: 112 FQA 114


>UniRef50_Q63E30 6-pyruvoyl tetrahydrobiopterin synthase n=100 Tax=Bacilli
           RepID=Q63E30_BACCZ
          Length = 163

 Score =  114 bits (287), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 41/131 (31%), Positives = 61/131 (46%), Gaps = 15/131 (11%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + K+FTF+AAH L       KC  LHGH++ V   I+G V    G  IDF ++K  +
Sbjct: 31  RVMVSKEFTFDAAHHLHCYE--GKCKNLHGHTYKVVFGISGYV-NEIGLAIDFGDIKEIW 87

Query: 63  K-PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV-----------PLLSAVMVKE 110
           K      LDH YLN+     N T+E +  WI++++   +             +  V + E
Sbjct: 88  KNEIEIYLDHRYLNETLPAMNTTAENMVVWIYEKMAEALTKDNRANEYKGARVEFVRLFE 147

Query: 111 TCTAGCIYRGE 121
           T T+    R E
Sbjct: 148 TPTSYAEVRRE 158


>UniRef50_C1CXM4 Putative 6-pyruvoyl tetrahydrobiopterin synthase, (PTP synthase)
           n=3 Tax=Bacteria RepID=C1CXM4_DEIDV
          Length = 136

 Score =  114 bits (287), Expect = 7e-25,   Method: Composition-based stats.
 Identities = 45/136 (33%), Positives = 64/136 (47%), Gaps = 21/136 (15%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG------WIIDF 55
           M  TL  +FTF++AH +        CGRLHGH++ VR+E+T      +        + DF
Sbjct: 1   MPWTLRTEFTFDSAHVIAGYD--GPCGRLHGHTYRVRMELTSSRLRPSAHVRRNIMVADF 58

Query: 56  AELKAAFKPTY-ERLDHHYLNDIPGL-ENPTSEVLAKWIWDQVKPVVPLL---------- 103
             LK A K      LDH YLND+P L ++ T+EV+A +I  +    V             
Sbjct: 59  RTLKWAKKDVTGGGLDHTYLNDVPELGDDTTAEVIAAYIHRKTMERVRADLEPGDDGADL 118

Query: 104 -SAVMVKETCTAGCIY 118
              V + ET  + C Y
Sbjct: 119 KLKVTLWETPDSSCEY 134


>UniRef50_A0B6A5 Putative uncharacterized protein n=1 Tax=Methanosaeta thermophila
           PT RepID=A0B6A5_METTP
          Length = 120

 Score =  114 bits (285), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 37/119 (31%), Positives = 57/119 (47%), Gaps = 13/119 (10%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
             F+AAH LP      KC R+HGH++ V + + G+     G IIDF  LK       + L
Sbjct: 7   MEFDAAHHLPM--HDGKCSRIHGHTYRVEVVLQGDPGDD-GMIIDFYMLKKIVGRVIQEL 63

Query: 70  DHHYLNDIPGLENPTSEVLAKWIWDQVKPVV--------PLLSAVMVKETCTAGCIYRG 120
           DH+ LN +  L+NPT+E++A  I  ++   +          L +V + E      +  G
Sbjct: 64  DHNNLNTV--LQNPTAEMIASHIHRRLHEELKMTGLSDKATLLSVRLWEGRDKWVMVDG 120


>UniRef50_O66626 6-carboxy-5,6,7,8-tetrahydropterin synthase n=8 Tax=Aquificales
           RepID=QUED_AQUAE
          Length = 162

 Score =  113 bits (284), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 40/162 (24%), Positives = 68/162 (41%), Gaps = 42/162 (25%)

Query: 2   MSTTLFKDFTFEAAHRL-------------PHVPEGHKCGRLHGHSFMVRLEITGEVDPH 48
           M   + K F FEA HR+                   +KC  LHGHS+++ + +  +    
Sbjct: 1   MKWEISKTFRFEAGHRVWKQNLTYGRGAQFTKEKPVNKCVNLHGHSYVLEVTVGSDTLSE 60

Query: 49  TGWIIDFAELKAAFKPTYERLDHHYLNDI-----PGLEN----------------PTSEV 87
              ++DF  +K A K   E +DH ++ D+     P L++                PT+E 
Sbjct: 61  QDMVMDFYHVKNALKGLIEEIDHSFIIDVNDPMYPELKDVAEKYGAMKIFPVEFCPTAEA 120

Query: 88  LAKWIWDQVKPVVPL--------LSAVMVKETCTAGCIYRGE 121
           LAK+ +D +K  +          +  V++ ET T+   Y+ E
Sbjct: 121 LAKFFYDFLKKRLEEAGLLGEVKVVKVVLWETATSKAEYKEE 162


>UniRef50_O29809 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=1
           Tax=Archaeoglobus fulgidus RepID=QUED_ARCFU
          Length = 115

 Score =  113 bits (284), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 36/117 (30%), Positives = 56/117 (47%), Gaps = 6/117 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    +F AAH +P      KCG++HGH+F V +EI+G+V    G ++DF +LK   
Sbjct: 4   EMIIGISTSFSAAHSIPGHK---KCGKVHGHNFKVEVEISGKV-KENGMVMDFFDLKRIV 59

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
                + DH  LN+   +E PTSE +   I+ ++      +  V V E        R
Sbjct: 60  NEVVAKFDHTLLNE--QIEIPTSENICLRIFSELAEKGLNVRRVRVAENEDKWAEIR 114


>UniRef50_Q5KZY1 6-pyruvoyltetrahydropterin synthase(PTP synthase) n=7 Tax=Bacteria
           RepID=Q5KZY1_GEOKA
          Length = 134

 Score =  113 bits (283), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 14/128 (10%)

Query: 7   FKDFTFEAAHRL--------PHVPEGHKCGR--LHGHSFMVRLEITGEVDPHTGWIIDFA 56
            + + F +AHRL         +     KC     HGH++ + + + G+ DP TG +++ A
Sbjct: 2   TRRYYFSSAHRLHSDQLTNEENQRLFGKCNNRYGHGHNYCLEVTVIGKPDPITGMVVNLA 61

Query: 57  ELKAAF-KPTYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAVMVKETC 112
           EL     +    + DH +LN D    +  NPT+E +   IW+ + P +  L  + + ET 
Sbjct: 62  ELDEIVNREVLVKFDHKHLNLDTDEFKQINPTAENIVIVIWELLAPHLSSLYKIGLWETQ 121

Query: 113 TAGCIYRG 120
                Y G
Sbjct: 122 KNYFEYFG 129


>UniRef50_A8G2B1 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Cyanobacteria
           RepID=A8G2B1_PROM2
          Length = 308

 Score =  112 bits (282), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 18/134 (13%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L     F AAHRL         +     KC R+  HGH++ + + + G+++P TG 
Sbjct: 152 MEALLTVQSHFNAAHRLAKDEISLSENKKIYGKCARINGHGHNYFLDVTVRGQINPRTGM 211

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV----PLL 103
           I D   L++       E+ DH +LN DI   +   PT E +A  I D +   +      L
Sbjct: 212 ICDLPSLQSIIDDLIVEQFDHTFLNKDIEYFKTCVPTCENIALHISDILSSPIKNIGANL 271

Query: 104 SAVMVKETCTAGCI 117
             + ++E+      
Sbjct: 272 HKIRLQESPNNAAE 285



 Score = 99.8 bits (248), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 35/137 (25%), Positives = 67/137 (48%), Gaps = 21/137 (15%)

Query: 3   STTLFKDFTFEAAHR--LP------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWI 52
              + +   F ++HR  LP      ++    KC     HGH++ + + + GE+D   G +
Sbjct: 15  ECVITRRACFSSSHRYWLPEKSPEENLSLFGKCSFAPGHGHNYELIVSMGGELDSD-GMV 73

Query: 53  IDFAELK-AAFKPTYERLDHHYLNDI-PGLE-------NPTSEVLAKWIWDQVKPVVPLL 103
           ++ +++K +       +LD  +LND+ P           PT+E L K IW+++K  +P L
Sbjct: 74  LNLSDVKHSIKNEVTGQLDFRFLNDVWPEFNIYSQDGILPTTEALVKVIWNRLKDDLP-L 132

Query: 104 SAVMVKETCTAGCIYRG 120
           +++ + E+ T    Y G
Sbjct: 133 TSLRLYESPTLWADYFG 149


>UniRef50_D2QJ42 Putative uncharacterized protein n=1 Tax=Spirosoma linguale DSM 74
           RepID=D2QJ42_9SPHI
          Length = 143

 Score =  112 bits (280), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 16/133 (12%)

Query: 2   MSTTLFKDFTFEAAHRL--PHVPEG------HKCGRL--HGHSFMVRLEITGEVDPHTGW 51
               +F+   F AAHRL  P+  +        KC     HGH++ + +++ G +D  TG+
Sbjct: 9   PRVAVFRKEHFNAAHRLNNPNWSDEKNTRVYGKCNNPNYHGHNYELIVQVIGPIDDETGY 68

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVVPL--LSA 105
           +ID   L    K    +R DH  LN D       NP++E +A  I++ ++  +       
Sbjct: 69  VIDMKLLSDLIKEHVTDRFDHKNLNLDTEEFADLNPSAENIAIVIYNILRNQLSEGLDLK 128

Query: 106 VMVKETCTAGCIY 118
           + + ET      Y
Sbjct: 129 IRLYETERNFVEY 141


>UniRef50_C4XPJ5 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Desulfovibrio magneticus RS-1 RepID=C4XPJ5_DESMR
          Length = 123

 Score =  111 bits (279), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 3/99 (3%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              T+     F AAHRLP  P    C  +HGH+F V  EI  +     G + DF +++ A
Sbjct: 3   PIYTIAVAGDFSAAHRLPGHP--GPCAAMHGHNFQVTAEICADSLI-NGMVADFLDVRTA 59

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV 100
               +  LDH  LND+P L+ PT+EVLA +I  ++K  +
Sbjct: 60  MDAIFADLDHACLNDVPALDPPTAEVLAGYILSRLKARL 98


>UniRef50_A6GQ16 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Limnobacter sp. MED105 RepID=A6GQ16_9BURK
          Length = 116

 Score =  111 bits (279), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 42/118 (35%), Positives = 63/118 (53%), Gaps = 10/118 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +FK FTF+ AH+LP  P       LHGHS+   +   G      G+++  + L     
Sbjct: 1   MKVFKQFTFDVAHQLPDWPG------LHGHSYTAEVWFEGPATD--GYVVPESLLTQHVG 52

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
             ++RLDH YLN+   L  PTSE +A+WIWDQ++PV PL+   + + +   G  +  E
Sbjct: 53  AVHKRLDHSYLNEFIEL--PTSENIARWIWDQLRPVGPLIKVKVFRGSIGFGVEFDLE 108


>UniRef50_A3EQ19 Probable 6-pyruvoyl tetrahydrobiopterin synthase family protein n=3
           Tax=Leptospirillum RepID=A3EQ19_9BACT
          Length = 128

 Score =  111 bits (278), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 58/127 (45%), Gaps = 11/127 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    TF A+H LP  P    C +LHGH++ V +  +       G  +DF E +A  
Sbjct: 1   MFLISVTATFAASHILPGYP--GLCSKLHGHNWTVEVSWSSRGLDPLGMALDFHEAEALL 58

Query: 63  KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP-------LLSAVMVKETCT 113
            P  + LDH +LND P      PTSE +A +++ ++K ++         L  V V E   
Sbjct: 59  GPLIKELDHSHLNDHPFFRERLPTSEQVAFFLYTRLKEIMSSRTDSTVRLDQVAVTEMAP 118

Query: 114 AGCIYRG 120
              IYR 
Sbjct: 119 YKAIYRE 125


>UniRef50_Q46G73 6-pyruvoyltetrahydropterin synthase n=7 Tax=Euryarchaeota
           RepID=Q46G73_METBF
          Length = 117

 Score =  111 bits (278), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 39/117 (33%), Positives = 54/117 (46%), Gaps = 6/117 (5%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    L      ++AH LP      KCGR+HGH++ + + + GEV    G +IDF +LK 
Sbjct: 1   MTKMRLGVIDYIDSAHYLPGH---GKCGRVHGHTYKIEVLVEGEV-RENGMVIDFYDLKK 56

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
             K T E  DH  LN+I     P+SE L + I  ++         V V E     C 
Sbjct: 57  GIKETLEEYDHILLNEILEF--PSSEHLCQHIHSRLYKRFGFPLQVRVWEGEGKWCE 111


>UniRef50_A1SFN0 Putative uncharacterized protein n=1 Tax=Nocardioides sp. JS614
           RepID=A1SFN0_NOCSJ
          Length = 118

 Score =  110 bits (277), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 41/120 (34%), Positives = 66/120 (55%), Gaps = 9/120 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M  ++ + + FEAAH LP  P   KC R+HGHS+++ + +TGE+D   G ++DFAE+ A 
Sbjct: 1   MRISIVRRYRFEAAHTLPWHP--GKCSRIHGHSYVLEVHVTGELDDR-GVVMDFAEVDAI 57

Query: 62  FKPTY----ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
                      LDH  LN +  LENPT+E++A  I +++       + + + ET     +
Sbjct: 58  VDQHVLEGPAGLDHVDLNAL--LENPTAELVAVHIGERLDAAGLSWTMLRLWETEDGSVV 115


>UniRef50_A8Y1U6 C. briggsae CBR-PTPS-1 protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8Y1U6_CAEBR
          Length = 132

 Score =  110 bits (277), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 36/125 (28%), Positives = 63/125 (50%), Gaps = 16/125 (12%)

Query: 12  FEAAHRL--------PHVPEGHKCGR--LHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL         +     KC     HGH+++ ++++ GEVDP +G + D A+LK  
Sbjct: 7   FSAAHRLNSENLSVAENKETFGKCNNDNGHGHNYVWKVKLRGEVDPVSGMVYDLAKLKKE 66

Query: 62  FKPTYERLDHHYLN-DIPGLENP--TSEVLAKWIWDQVKPVV---PLLSAVMVKETCTAG 115
                + +DH  L+ D+   +    TSE +A +++ ++K V+    +L    ++ET    
Sbjct: 67  MNLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMYQKLKSVMSNPSVLYKCTIEETPKNV 126

Query: 116 CIYRG 120
             Y+G
Sbjct: 127 FTYKG 131


>UniRef50_C5A6K8 6-pyruvoyl tetrahydrobiopterin synthase (PtpS) n=9
           Tax=Thermococcaceae RepID=C5A6K8_THEGJ
          Length = 115

 Score =  110 bits (277), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 36/119 (30%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + + F FEAAH    V    +   +HGH+F + + + G +    G+++DF +L+  
Sbjct: 1   MRARIIERFKFEAAH---SVVVEGRPEEIHGHTFRLEVVVEGPLKN--GYVMDFIQLRKI 55

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP---LLSAVMVKETCTAGCI 117
                 +LDH  LN I   ENPT+E LA WI  +    +P    L  + + E    G  
Sbjct: 56  VGGIIGKLDHRNLNHI--FENPTTENLALWIAKETSRNLPEGVRLKRLTLWEGDDNGVE 112


>UniRef50_UPI0001C1695B hypothetical protein CRD_00116 n=2 Tax=Nostocaceae
           RepID=UPI0001C1695B
          Length = 422

 Score =  109 bits (274), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 13/132 (9%)

Query: 3   STTLFKDFTFEAAHRLP---HVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
             +L     F AAHRL       +  KC R HGH++ + + + GE+D  TG I+D   L 
Sbjct: 135 KISLTARSHFSAAHRLAPNLRAEKYGKCTRTHGHNYHLEVTVEGEMDGRTGTIVDLGCLH 194

Query: 60  AAF-KPTYERLDHHYLN-DIPGLEN----PTSEVLAKWIWDQVKPVVPL----LSAVMVK 109
               +   E  DH  +N DIP        PT+E +A+++ D ++  +      LS V + 
Sbjct: 195 ETVEREILELFDHSCINEDIPYFSTSHIVPTTENIARYMSDLLQFPISELGVKLSRVKLF 254

Query: 110 ETCTAGCIYRGE 121
           E+      Y G+
Sbjct: 255 ESDHLWVEYEGK 266



 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 36/134 (26%), Positives = 68/134 (50%), Gaps = 16/134 (11%)

Query: 2   MSTTLFKDFTFEAAHR--LPHVPEG------HKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   + +   F A+HR  LP + E         C +   HGH++++ + ++GE+D + G 
Sbjct: 1   MECIINRRAQFSASHRYWLPELGEAQNVGKFGLCAKFPGHGHNYVLFISMSGELDEY-GM 59

Query: 52  IIDFAELKAAFK-PTYERLDHHYLNDI-PGLE--NPTSEVLAKWIWDQVKPVVPLLSAVM 107
           +++ +++K   K      LD  YLN++    +   PT+E +A+ IW+++ P +P L  V 
Sbjct: 60  VLNLSDVKQVIKSEVTSELDFSYLNEVWEEFQATLPTTENIARVIWNRLTPHLP-LVRVQ 118

Query: 108 VKETCTAGCIYRGE 121
           + E       Y G+
Sbjct: 119 LFEHPQLWTEYEGK 132



 Score =  100 bits (250), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 37/124 (29%), Positives = 57/124 (45%), Gaps = 18/124 (14%)

Query: 12  FEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL         +     KC R+  HGH++ + + + GE+D  TG  +D   L   
Sbjct: 278 FSAAHRLADPTLSLEKNQTIYGKCSRINGHGHNYHLEVTVRGEIDSVTGMSVDLVGLNQI 337

Query: 62  FKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV----PLLSAVMVKETCT 113
            +    E +DH +LN D+P      PT+E +A +I D V+  +      L  V + E+  
Sbjct: 338 IQHYVIEPMDHSFLNQDLPYFTEVVPTAENIAVYISDVVRSPIEELGAKLHKVKLIESPN 397

Query: 114 AGCI 117
             C 
Sbjct: 398 NSCE 401


>UniRef50_A9M1Z1 6-pyruvoyl tetrahydrobiopterin synthase, putative n=26
           Tax=Neisseria RepID=A9M1Z1_NEIM0
          Length = 140

 Score =  109 bits (273), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 35/141 (24%), Positives = 63/141 (44%), Gaps = 26/141 (18%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV---DPHTGWIIDFAELKA 60
             + K FTF+++H L       KC  LHGH++ + + ++ +     P  G ++DF +LKA
Sbjct: 1   MKITKIFTFDSSHMLDG--HDGKCQNLHGHTYKLEITVSDDPVRGGPKDGMVMDFTDLKA 58

Query: 61  AFKP-TYERLDHHYLN-----------------DIPGLENP---TSEVLAKWIWDQVKPV 99
             K    +  DH ++                  ++  L  P   T+E +A  ++D++K  
Sbjct: 59  IVKQHITDPFDHAFIYHGGNGRESQIAALLEGWNMKTLRLPCRTTAENMAVEMYDRLKNA 118

Query: 100 VPLLSAVMVKETCTAGCIYRG 120
              +  V + ET T+   Y G
Sbjct: 119 GLNVCRVKLWETPTSCAEYEG 139


>UniRef50_P44123 6-carboxy-5,6,7,8-tetrahydropterin synthase n=31
           Tax=Pasteurellaceae RepID=QUED_HAEIN
          Length = 141

 Score =  109 bits (273), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 36/143 (25%), Positives = 70/143 (48%), Gaps = 27/143 (18%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV---DPHTGWIIDFAELK 59
              + K+F+F+ AH L       KC  LHGH++ +++EI+G++         +IDF++LK
Sbjct: 1   MFKISKEFSFDMAHLLDG--HDGKCQNLHGHTYKLQVEISGDLYKSGAKKAMVIDFSDLK 58

Query: 60  AAFKPTY-ERLDHHYLNDIPGLEN--------------------PTSEVLAKWIWDQVKP 98
           +  K    + +DH ++ D                           T+E +A++I++++K 
Sbjct: 59  SIVKKVILDPMDHAFIYDQTNERESQIATLLQKLNSKTFGVPFRTTAEEIARFIFNRLKH 118

Query: 99  VVPL-LSAVMVKETCTAGCIYRG 120
              L +S++ + ET T+ C Y+ 
Sbjct: 119 DEQLSISSIRLWETPTSFCEYQE 141


>UniRef50_Q1IPI9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Acidobacteria
           RepID=Q1IPI9_ACIBL
          Length = 137

 Score =  109 bits (272), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 36/136 (26%), Positives = 63/136 (46%), Gaps = 16/136 (11%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L +   F A+H           ++    KC     HGH++ + + + G VD  TG+
Sbjct: 1   MVVYLTRKSEFSASHHYHNPDFTAEENLRVFGKCNNSNGHGHNYTLEVTVKGTVDATTGF 60

Query: 52  IIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV--PLLSA 105
           ++D  +LK    +   + +DH YLN ++P  ++  PT+E +A  IW +++  +    L  
Sbjct: 61  VVDLKQLKEIMNREVVDAMDHRYLNHEVPEFKSQIPTTENIAIAIWKRLEGKLHVAKLHR 120

Query: 106 VMVKETCTAGCIYRGE 121
           V + E       Y GE
Sbjct: 121 VRLYEMHDLWVDYLGE 136


>UniRef50_D1CA69 Putative uncharacterized protein n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1CA69_SPHTD
          Length = 125

 Score =  108 bits (270), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 55/125 (44%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +     FEAAHRL    +     RLHGH++ V +E+ G      G + D   LKA  
Sbjct: 1   MFAIGVVAQFEAAHRLRG--DFGPASRLHGHTYRVEVEVAGPQLNDDGTLFDLGLLKAWV 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGC 116
                 L++  L+ +P     N T+E +A+++ + + P +      +  V V E+  A  
Sbjct: 59  DEAVGELNYQNLDVLPAFAQRNSTAEEVARFLRETLAPRLHGKGLRMLTVRVWESPQAYA 118

Query: 117 IYRGE 121
             + E
Sbjct: 119 ACQWE 123


>UniRef50_UPI0001C418E1 queuosine biosynthesis protein QueD n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C418E1
          Length = 119

 Score =  107 bits (269), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 5/118 (4%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGE--VDPHTGWIIDFAELKA 60
             TL  +      H+L    +G KC + HGH + V L +        +   I+D  +++A
Sbjct: 1   MLTLVSEHRIYGCHKLKD--QGGKCTQWHGHQYRVILTLQAPYKDLDYRNMIMDTYDIEA 58

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
            F      +DH  LN+    ENPT E ++K+ +D +K  +  L +V V ET   G  Y
Sbjct: 59  IFNEFIG-VDHLNLNEFMDSENPTMEEMSKFFYDGLKDKIECLVSVGVYETPETGVTY 115


>UniRef50_B3T9P1 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG7F19 RepID=B3T9P1_9ARCH
          Length = 120

 Score =  106 bits (265), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 38/120 (31%), Positives = 58/120 (48%), Gaps = 10/120 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP----HTGWIIDFAE 57
           M T +  +F  + AH L   P   KCG+ HGH+  + +E  GE+          II+F E
Sbjct: 1   MQTKIGVEFEIDFAHTLKGHP---KCGKPHGHTARIIVEAAGELKNGSTYKDNMIIEFDE 57

Query: 58  LKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           +K     T ++LDH  L+ +     PTSE +A WI++ +K  +P +  V   E     C 
Sbjct: 58  MKKICWQTLQQLDHTNLDSMFDF--PTSENIAMWIFEHLKDKIP-IYGVKFFEGSNKYCE 114


>UniRef50_A3VUJ4 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Parvularcula
           bermudensis HTCC2503 RepID=A3VUJ4_9PROT
          Length = 136

 Score =  106 bits (265), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 44/102 (43%), Positives = 56/102 (54%), Gaps = 3/102 (2%)

Query: 10  FTFEAAHRLPHV---PEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           F FEAAH L  +      H    +HGHSF V + +        GWI+DFAELKAA +   
Sbjct: 22  FFFEAAHELGEMKPEDSAHLYAEIHGHSFEVTVTLAAATIEPEGWIMDFAELKAACETVR 81

Query: 67  ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV 108
             LDH  LN I GL  PT E LA +I +++ P +P LS V +
Sbjct: 82  GLLDHRLLNRIEGLSRPTLERLADFIIERLSPDLPALSEVEI 123


>UniRef50_C1ZE85 PreQ(0) biosynthesis protein QueD n=2 Tax=Planctomycetaceae
           RepID=C1ZE85_PLALI
          Length = 136

 Score =  105 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 38/138 (27%), Positives = 57/138 (41%), Gaps = 23/138 (16%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  +  F   HRL +     KC  LHGH+    + + GE     G ++DF +LK   
Sbjct: 1   MFEVSSEIQFCYGHRLLNYS--GKCRHLHGHNGKAIITLAGESLDERGMLVDFGDLKRTV 58

Query: 63  -KPTYERLDHHY-----------LND-------IPGLENPTSEVLAKWIWDQVKPVVPLL 103
            +   + LDH             L D       IP  ENPT+E +AK I+++   V   +
Sbjct: 59  SQWIDDHLDHRMVLCERDPMVKILRDAGEPLYLIP--ENPTAENIAKLIYEKTVEVGLPV 116

Query: 104 SAVMVKETCTAGCIYRGE 121
             V + ET     +YR  
Sbjct: 117 IQVGLWETAKNYAVYRER 134


>UniRef50_A3ZTI8 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Planctomycetaceae
           RepID=A3ZTI8_9PLAN
          Length = 167

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 42/142 (29%), Positives = 63/142 (44%), Gaps = 26/142 (18%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           MS  + +   F A HRL     G KC   HGH+++    +T +     G +IDFA+LKA 
Sbjct: 9   MSLVIMRRIKFCAGHRL--YKHGGKCEFFHGHNYVADFYVTADEVDDVGRVIDFADLKAK 66

Query: 62  FKPTYER-LDHHYL------NDIPGLE------------NPTSEVLAKWIWDQVKPVV-- 100
           FK   +   DH +L      N I  ++            NPT+E +A+++ D V P +  
Sbjct: 67  FKGWLDEHWDHGFLLSEQDENGINAIKQVVPCKYFVMPYNPTAENMARYLLDYVCPELLD 126

Query: 101 ---PLLSAVMVKETCTAGCIYR 119
                   V++ ET  A    R
Sbjct: 127 QSNVRPVKVVIWETEEAFAEAR 148


>UniRef50_D2ML00 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
           Poribacteria sp. WGA-A3 RepID=D2ML00_9BACT
          Length = 143

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 41/132 (31%), Positives = 59/132 (44%), Gaps = 15/132 (11%)

Query: 3   STTLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWI 52
              + + + F AAHRL         +     KC     HGH + V + +TGE+DP TG +
Sbjct: 4   KICVTRQYRFCAAHRLHTDALSDDVNRKVYDKCNNPNGHGHDYTVFVTVTGELDPQTGEV 63

Query: 53  IDFAELKAAF-KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVM 107
            D   L     +   ER DH +LN  P  +    T E L K+IWD++   +P   L  + 
Sbjct: 64  TDIHALDGLVNRKIVERFDHRHLNHDPAFQQLVTTGENLVKFIWDELVDDIPGGRLEKIG 123

Query: 108 VKETCTAGCIYR 119
           + ET      YR
Sbjct: 124 LIETRDNYFEYR 135


>UniRef50_Q2PY17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bacteria
           RepID=Q2PY17_9BACT
          Length = 137

 Score =  104 bits (261), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 18/137 (13%)

Query: 3   STTLFKDFTFEAAHRL--------PHVPEGHKCGR--LHGHSFMVRLEITGEVDPHTGWI 52
              + +   F AAHRL         +      C     HGH+F + + + GEV+  TG++
Sbjct: 1   MIYIQRRAIFSAAHRLANPSWSDEKNQAVFGHCANEYSHGHNFQLIVTVKGEVNTDTGFV 60

Query: 53  IDFAELKAAFK-PTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVK----PVVPLLS 104
           ++  +LKA       + +DH  LN D+P ++   P++E LA   W Q++         L 
Sbjct: 61  MNMVDLKAIMDSEIIQHVDHRNLNHDVPFMQGIMPSTENLAMIFWQQIEGPIAKHGAALH 120

Query: 105 AVMVKETCTAGCIYRGE 121
            + + ET      Y GE
Sbjct: 121 CIRIVETENNMVEYYGE 137


>UniRef50_D1JB18 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=uncultured
           archaeon RepID=D1JB18_9ARCH
          Length = 120

 Score =  104 bits (261), Expect = 8e-22,   Method: Composition-based stats.
 Identities = 33/111 (29%), Positives = 54/111 (48%), Gaps = 10/111 (9%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F AAH LP      KC  LHGH++ V + + GE    T  + DF+E+KA  +   + +DH
Sbjct: 9   FSAAHSLPR--HTGKCKNLHGHTYRVDIVVEGEKKKDTECVADFSEVKALVEEVLDLVDH 66

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVP------LLSAVMVKETCTAGC 116
            +LN+I  +  PTSE +A ++  + +           L ++ + E      
Sbjct: 67  KHLNEI--IAYPTSENIALFLRAEFEKKFKDSNFGVTLHSIKIWEGKDKWV 115


>UniRef50_Q1IPJ0 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Candidatus Koribacter
           versatilis Ellin345 RepID=Q1IPJ0_ACIBL
          Length = 135

 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 15/131 (11%)

Query: 2   MSTTLFKDFTFEAAHRL--PHVPEG------HKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L + + F A+HRL  P + E        KC     HGH++ + + + G+V P TG 
Sbjct: 1   MKAHLTRRYWFVASHRLHTPRLSEAENREVYGKCNNPFGHGHNYALEVTVGGQVAPDTGM 60

Query: 52  IIDFAELKAAF-KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAV 106
           + + A++     K   ER DH  LN +   +   PT+E L   I++ +K  +    L  V
Sbjct: 61  VYNLADVDRVVRKHILERYDHQNLNCLKEFQELVPTTENLCLAIFEILKRNLAEIHLDKV 120

Query: 107 MVKETCTAGCI 117
            ++ET      
Sbjct: 121 RLEETSQNSFE 131


>UniRef50_B3QUQ1 Putative uncharacterized protein n=1 Tax=Chloroherpeton thalassium
           ATCC 35110 RepID=B3QUQ1_CHLT3
          Length = 153

 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 35/137 (25%), Positives = 65/137 (47%), Gaps = 21/137 (15%)

Query: 6   LFKDFTFEAAHRL--PHVPEGH------KCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           + +   F AAHRL  P   +        +C  +  HGH++ + + + G VD  TG++ D 
Sbjct: 17  VTRKVHFSAAHRLFNPEFSDAENELIYDRCNNIYGHGHNYELEVTLKGPVDKATGYVFDL 76

Query: 56  AELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP-------LLS 104
            +L     +    ++DH +LN D+  L++  P++EVL+   W+ ++  +         L 
Sbjct: 77  KKLDKILSEEILSKVDHKHLNFDVEMLKDMIPSAEVLSIVFWNAIQNRLSELGYTQVALY 136

Query: 105 AVMVKETCTAGCIYRGE 121
            V + E+      YRG+
Sbjct: 137 EVKLFESERNFVRYRGD 153


>UniRef50_Q675S7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Oikopleura dioica
           RepID=Q675S7_OIKDI
          Length = 136

 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 32/133 (24%), Positives = 59/133 (44%), Gaps = 17/133 (12%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M  ++ +       HRL         +     KC     HGH++ ++  I GE+   TG 
Sbjct: 1   MKCSIIRTEKICTGHRLHSPYLTDEENRKVYGKCNHPNGHGHNYTIQAVIEGEIIKETGM 60

Query: 52  IIDFAELKAAFKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL----LS 104
           +++  +LK A      +LDH  ++ D+   +N   T+E +A+WI+ Q+   +P     L 
Sbjct: 61  VMNLVDLKVAMWKVLSQLDHRNVDKDVEYFKNVPSTAENVAQWIFIQLSQELPTGSYHLK 120

Query: 105 AVMVKETCTAGCI 117
            +++ ET      
Sbjct: 121 KIILDETDKNRVE 133


>UniRef50_D2R401 Putative uncharacterized protein n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R401_9PLAN
          Length = 169

 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 32/134 (23%), Positives = 51/134 (38%), Gaps = 19/134 (14%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + ++  F   HRL +     KC  LHGH+    + I      + G ++DF+++K    
Sbjct: 29  FRVSREIDFCYGHRLLNYD--GKCRHLHGHNGRAVITIESSSLDNRGMVMDFSDIKRVVS 86

Query: 64  PTYER-LDHHY-----------LNDI--PGL---ENPTSEVLAKWIWDQVKPVVPLLSAV 106
              +  LDH             L D+  P     ENPT+E + K I +        +   
Sbjct: 87  SWIDENLDHRMLLCKRDPYVQILKDLGEPLFLLDENPTAENICKLIHEFTASRGFPIVET 146

Query: 107 MVKETCTAGCIYRG 120
            + ET      YR 
Sbjct: 147 QLWETPHCFATYRA 160


>UniRef50_A0L5B3 Putative uncharacterized protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L5B3_MAGSM
          Length = 142

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 40/131 (30%), Positives = 59/131 (45%), Gaps = 19/131 (14%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG------EVDPHTGWIIDFAE 57
             + + F FE+AHRLP+     KC RLHGHS+ + +  +G      E DP +G++ DF  
Sbjct: 1   MKIARMFKFESAHRLPY--HDGKCHRLHGHSYRLEMIFSGTVRQPDEKDPQSGFVADFGI 58

Query: 58  LKAAFKP--TYERLDHHYLND-IPGLENPTSEVLAKWIWDQVKPVVPL--------LSAV 106
           +    K       LDH  LN  +PG+   ++E L+ WI       +          +  V
Sbjct: 59  VNDLVKEQLIDRYLDHRDLNASVPGIPYTSAEYLSAWIVGWCMRELEGHPQLGDLKIERV 118

Query: 107 MVKETCTAGCI 117
            V ET  A   
Sbjct: 119 RVWETINAWAE 129


>UniRef50_B8G7W6 Putative 6-pyruvoyl tetrahydropterin synthase n=5 Tax=Bacteria
           RepID=B8G7W6_CHLAD
          Length = 130

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 52/124 (41%), Gaps = 8/124 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +     FEAAHRL          R+HGH++ +   +TGE     G ++D ++L+AA 
Sbjct: 1   MYEIGVSAQFEAAHRLEG--NFGPATRMHGHTYRLEAIVTGERLQPDGTLVDMSQLQAAV 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGC 116
           +     L +  L  + GL   N T+E +A + W ++   +         V + E      
Sbjct: 59  QRVVADLHYRDLGTVEGLRDINTTAEHVAYYCWRRIAAALSGAGLTTLTVRIWENPQVYA 118

Query: 117 IYRG 120
            Y  
Sbjct: 119 AYSE 122


>UniRef50_UPI0001C378A0 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Ruminococcus
           flavefaciens FD-1 RepID=UPI0001C378A0
          Length = 165

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 34/140 (24%), Positives = 54/140 (38%), Gaps = 25/140 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG----EVDPHTGWIIDFAEL 58
              L    +F++AH L       KC  +HGH + V + I G    +     G +IDF++L
Sbjct: 27  MYYLKTSASFDSAHFLAGYQ--GKCANIHGHRWKVEVSICGGSLQQEGTKRGMLIDFSDL 84

Query: 59  KAAFKPTYERLDHHYLNDIPGLEN-------------------PTSEVLAKWIWDQVKPV 99
           K A     +  DH  + +   L+                    PT+E  AK   + +   
Sbjct: 85  KKAVHDMADSFDHALIYETGSLKETTIAAMNDEGFHIIEVPFRPTAENFAKHFHELLTAK 144

Query: 100 VPLLSAVMVKETCTAGCIYR 119
              +S+V V ET     +Y 
Sbjct: 145 GLHISSVTVYETPDNCAVYE 164


>UniRef50_Q604L2 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Methylococcus
           capsulatus RepID=Q604L2_METCA
          Length = 137

 Score =  101 bits (252), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 38/135 (28%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             ++ K+  F   HRL H     KC  LHGHS    + ++       G + DFA++ AA 
Sbjct: 1   MYSVTKEIFFCYGHRLMHHS--GKCRHLHGHSVRAAITVSASDLNFQGMVCDFADISAAA 58

Query: 63  KPTYE-RLDHHYL--NDIPGL--------------ENPTSEVLAKWIWDQVKPVVPLLSA 105
           +   +  LDH+ L   D P L              ++PT+E LA+ I+  ++     +  
Sbjct: 59  RDFIDTHLDHNLLLHRDDPLLPLLQQAGERVLALEQHPTAEALAEMIYRDLRRKGFAVQN 118

Query: 106 VMVKETCTAGCIYRG 120
           V + ET +A   YR 
Sbjct: 119 VTLWETSSACASYRE 133


>UniRef50_A0Q1F5 6-pyruvoyl tetrahydrobiopterin synthase, putative n=5
           Tax=Clostridiales RepID=A0Q1F5_CLONN
          Length = 139

 Score =  100 bits (251), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 32/140 (22%), Positives = 54/140 (38%), Gaps = 25/140 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT----GWIIDFAEL 58
              L    +F++AH L       KC  +HGH + V +EI  E    T    G I+DF + 
Sbjct: 1   MYILKTKQSFDSAHFLSEYD--GKCSNIHGHRWTVEIEIQSETLNPTGKLKGMIVDFGDF 58

Query: 59  KAAFKPTYERLDHHYLND-----IPGLEN--------------PTSEVLAKWIWDQVKPV 99
           K   K   +  DH  + +     +  L+N              PT+E LA   ++ ++  
Sbjct: 59  KKDLKSIVDFYDHSLIIEQNSMKLEALDNLKNDGFRIIEVEFRPTAENLAHHFFNLMEQK 118

Query: 100 VPLLSAVMVKETCTAGCIYR 119
              +    + ET      ++
Sbjct: 119 GYNVRKSTIYETPNNCATFQ 138


>UniRef50_C3KVW1 Queuosine biosynthesis protein QueD n=22 Tax=Bacteria
           RepID=C3KVW1_CLOB6
          Length = 143

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 35/141 (24%), Positives = 53/141 (37%), Gaps = 25/141 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH----TGWIIDFAEL 58
              L  + +F++AH L       KCG +HGH + V++++  E         G IIDF +L
Sbjct: 1   MYILKAEHSFDSAHFLAGYE--GKCGNIHGHRWKVKIQVQAESLVQGGQLDGMIIDFGDL 58

Query: 59  KAAFKPTYERLDHHY-----------LNDI--PGLE------NPTSEVLAKWIWDQVKPV 99
           K   K   +  DH             LN +   G         PT+E  A + +  +K  
Sbjct: 59  KKDVKSMVDYYDHALIIEKGTMREQSLNSLREDGFRIIEVNFRPTAENFALFFYKTMKDK 118

Query: 100 VPLLSAVMVKETCTAGCIYRG 120
              +    V ET      Y  
Sbjct: 119 GYNVKNSTVYETPNNSATYEE 139


>UniRef50_Q7UGM2 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Rhodopirellula
           baltica RepID=Q7UGM2_RHOBA
          Length = 137

 Score =  100 bits (250), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 26/135 (19%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
            + FTF + HRL  V    KC  LHGH++++ + +TGE     G I+DF +LK   K   
Sbjct: 1   MRRFTFCSGHRL--VGHEGKCQNLHGHNYVLEVYVTGEEQDAIGRILDFKQLKTRCKNWI 58

Query: 67  ER-LDHHYL---NDIPGLE---------------NPTSEVLAKWIWDQVKPVV-----PL 102
           +   DH ++    D  GL+               NPT+E +AK   +++ P +       
Sbjct: 59  DENWDHTFVLWKKDQNGLDAIRSSEPHRIYELESNPTAENMAKHFLEKICPSILGDSGAT 118

Query: 103 LSAVMVKETCTAGCI 117
              V + E+      
Sbjct: 119 AYKVRLWESEETYAE 133


>UniRef50_Q04S36 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Leptospira
           RepID=Q04S36_LEPBJ
          Length = 136

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 30/124 (24%), Positives = 53/124 (42%), Gaps = 7/124 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAA 61
              +  +  FE++H L           +HGHS+ V L ++G  +    G   DF   K  
Sbjct: 8   RFYIRIEERFESSHFLYKYFPDGSDEPIHGHSWKVELYLSGRKNIGEDGISFDFLTSKQR 67

Query: 62  FKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAG 115
            K    +LDH  +N++   +  NPTSE +A+W +  +K  V      +  +++ E     
Sbjct: 68  LKELVGKLDHILINELEEFKKINPTSENIARWFYHYLKESVHSAGGRVDKIVIHEGPENL 127

Query: 116 CIYR 119
             + 
Sbjct: 128 AFFE 131


>UniRef50_A6LWG4 6-pyruvoyl tetrahydrobiopterin synthase, putative n=4
           Tax=Clostridium RepID=A6LWG4_CLOB8
          Length = 142

 Score = 99.0 bits (246), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 32/144 (22%), Positives = 56/144 (38%), Gaps = 27/144 (18%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAEL 58
              +  +  F+ AH L       KC  +HGH + +  ++  E     G     + DF   
Sbjct: 1   MFKIKSEVQFDMAHYLSGYE--GKCSNIHGHRYKLIAKLKSEKLHQDGQLRGMVDDFGNF 58

Query: 59  KAAFKPTYERLDHHYL---ND--------IPGLEN----------PTSEVLAKWIWDQVK 97
           K   K   E  DH  +   N+        +  L+N          PT+E +++ I++++K
Sbjct: 59  KNILKEIAETFDHKLIIENNEDGKALVKNLEELQNNFNIYLVDYRPTAEEMSRDIFNRLK 118

Query: 98  PVVPLLSAVMVKETCTAGCIYRGE 121
                +  V + ET    CIY  +
Sbjct: 119 AKGLSVCEVELFETPNNSCIYTED 142


>UniRef50_C2D910 Possible 6-pyruvoyltetrahydropterin synthase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D910_9ACTN
          Length = 154

 Score = 98.2 bits (244), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 25/142 (17%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAE 57
           M  +L     F AAH L +     KC  LHGH + V + +  E     G     +IDF E
Sbjct: 15  MGFSLKTQSYFNAAHFLTNYK--GKCENLHGHRWQVIVYLYKENLSSQGEDKDMLIDFGE 72

Query: 58  LKAAFKPTYERLDHHYLND--------IPGLEN-----------PTSEVLAKWIWDQVKP 98
            K   +   ++ DH ++ +        +  LE             TSE  A++ + +   
Sbjct: 73  FKQIVRAEVKKFDHTFIVEENSLHPETVRALEQETFKLTFVPFRTTSENFARYFYQRFCA 132

Query: 99  VVPLLSAVMVKETCTAGCIYRG 120
           +   +  V V ET     IY  
Sbjct: 133 LGLPVVRVEVDETPHNCAIYEA 154


>UniRef50_C1AB96 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1AB96_GEMAT
          Length = 151

 Score = 97.8 bits (243), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 35/125 (28%), Positives = 58/125 (46%), Gaps = 16/125 (12%)

Query: 1   MMSTTLFKDFTFEAAHRLP--------HVPEGHKCG--RLHGHSFMVRLEITGEVDPHTG 50
           M  T+L +   F AAHR          +      C     HGH+++  + + G VD  TG
Sbjct: 10  MPRTSLTRRVLFAAAHRYRRPDWSDQENADVFGACAHPNYHGHTYLCDVTVAGPVDEETG 69

Query: 51  WIIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN----PTSEVLAKWIWDQVKPVVPLLS 104
           +++D   L     +   ER DH  +N D+P        PT E LA++I ++V+  +   +
Sbjct: 70  FVVDLGFLDRVLQREVRERFDHRNINLDVPEFAEGRLIPTGENLARFICERVQAALAHTT 129

Query: 105 AVMVK 109
           A +V+
Sbjct: 130 ARVVR 134


>UniRef50_D0MDN2 Putative uncharacterized protein n=1 Tax=Rhodothermus marinus DSM
           4252 RepID=D0MDN2_RHOM4
          Length = 156

 Score = 97.8 bits (243), Expect = 9e-20,   Method: Composition-based stats.
 Identities = 38/139 (27%), Positives = 58/139 (41%), Gaps = 28/139 (20%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K F FEAAHRLP  P    C  LHGHS+ + + + G  D   G ++DF +LK   +
Sbjct: 1   MKVAKRFRFEAAHRLPWHP--GACRHLHGHSYRLVVGLEGNPDAR-GILVDFQDLKRLVQ 57

Query: 64  PTYERLDHHYL--NDIPGLE---------------NPTSEVLAKWIW--------DQVKP 98
           P  +  DH  L  +D   L+               + T+E L  ++         D ++ 
Sbjct: 58  PLIDTWDHATLVASDDTALQDALDALGSRYVVLPFDSTAENLCAYVADYLIREAGDWLRA 117

Query: 99  VVPLLSAVMVKETCTAGCI 117
                  V + ET T+   
Sbjct: 118 RGVRRLWVRLAETETSFAE 136


>UniRef50_A7BS03 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Beggiatoa sp. PS
           RepID=A7BS03_9GAMM
          Length = 148

 Score = 97.8 bits (243), Expect = 9e-20,   Method: Composition-based stats.
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 23/140 (16%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    +     +E AHRL H     KC  +HGHS    +E+        G+++DFA++K 
Sbjct: 1   MNMYKIIVKIKYEYAHRLLH--HTGKCRHVHGHSGEAIIELASNTLNDNGFVMDFADVKT 58

Query: 61  AFKPTYERL-DHHYL-NDIPGL---------------ENPTSEVLAKWIWDQV----KPV 99
             K    +  DH YL N+   L               E PT+EV+A+ +++Q     +P 
Sbjct: 59  PLKKWINQFWDHAYLANESDPLLPAFKSENMNIYTFPEEPTAEVMARHLFEQAAILERPP 118

Query: 100 VPLLSAVMVKETCTAGCIYR 119
             +L+ V ++ETCT    Y+
Sbjct: 119 GVILTRVTIRETCTGQASYQ 138


>UniRef50_UPI0001B56D65 putative 6-pyruvoyl tetrahydropterin synthase n=1
          Tax=Streptomyces sp. C RepID=UPI0001B56D65
          Length = 146

 Score = 97.4 bits (242), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 31/79 (39%), Positives = 46/79 (58%), Gaps = 2/79 (2%)

Query: 3  STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG--EVDPHTGWIIDFAELKA 60
            T+ K+F F A+H L  +P  H C R+HGH+++V LE+ G  E     G++ D+ +L A
Sbjct: 1  MLTITKEFHFSASHVLDRLPGWHPCARMHGHNYVVVLELRGRREDLTEAGFVRDYRDLDA 60

Query: 61 AFKPTYERLDHHYLNDIPG 79
            K   E LDH +LN+  G
Sbjct: 61 FKKWVDETLDHRHLNEAMG 79


>UniRef50_C5RIU8 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Clostridium
           cellulovorans 743B RepID=C5RIU8_CLOCL
          Length = 145

 Score = 96.7 bits (240), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 25/139 (17%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAELK 59
             L  + + ++AH L       KC  +HGH + V  EI  +         G I+DF   K
Sbjct: 5   YKLVSEHSMDSAHFLKDYD--GKCSNIHGHRWRVVAEIFSDQLINEGAEKGMIVDFGIFK 62

Query: 60  AAFKPTYERLDHHYLND-------------IPGLE------NPTSEVLAKWIWDQVKPVV 100
              +   +  DH  + +               G         PT+E LAK+ ++Q+K   
Sbjct: 63  NDIRELVDFYDHCLIVEKGSLKTELFQMLTTEGFRVEEVSFRPTAENLAKFFFEQLKKKG 122

Query: 101 PLLSAVMVKETCTAGCIYR 119
             + +V+V ET      Y 
Sbjct: 123 HNMKSVVVYETPNNAATYE 141


>UniRef50_B2UBF2 Queuosine biosynthesis protein QueD n=85 Tax=cellular organisms
           RepID=B2UBF2_RALPJ
          Length = 158

 Score = 94.8 bits (235), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 40/145 (27%), Positives = 63/145 (43%), Gaps = 34/145 (23%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-----PHTGWIIDFAEL 58
            ++ +   F+A HR+P      +C  LHGH + + L +TGEV         G I+DF ++
Sbjct: 5   VSITRRLEFDAGHRIPG--HAGQCRNLHGHRYQLELTLTGEVLHNDKAADDGMILDFGDV 62

Query: 59  KA-AFKPTYERLDHH------------YLNDIPG-------LENPTSEVLAKWIWDQVKP 98
           K  A K   +  DH             +LND+ G        + PT E LA+  +D ++P
Sbjct: 63  KQLANKHLVDLWDHAFLVYRGDTKLVEFLNDMEGGHKTVVLNDVPTVENLAQVAFDILEP 122

Query: 99  VVP-------LLSAVMVKETCTAGC 116
           V          LS +++ ET     
Sbjct: 123 VFRNAFGHHLRLSKLVLYETPNCWA 147


>UniRef50_UPI0001B56179 putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Streptomyces
           sp. AA4 RepID=UPI0001B56179
          Length = 264

 Score = 94.0 bits (233), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 38/114 (33%), Positives = 51/114 (44%), Gaps = 10/114 (8%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           F FEAAH L  +PEGHKCGR HGHS+ V L +  +  P               +     L
Sbjct: 148 FAFEAAHHLEGLPEGHKCGRPHGHSYRVDLRLDQQTSPRRR----ARLRSRLAEYLDRYL 203

Query: 70  DHHYLNDIPGLENPTSEVLAKWIWDQV-----KPVVPLLSAVMVKETCTAGCIY 118
           DH  LN +  L+ PTSE+LA+ +               + AV V E+      +
Sbjct: 204 DHRDLNAVLELQ-PTSELLAEHLCAWTLSQADAREAAAVQAVRVWESPRRWAEF 256



 Score = 81.7 bits (201), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 36/105 (34%), Positives = 51/105 (48%), Gaps = 7/105 (6%)

Query: 10  FTFEAAHRLPHVPEGH-KCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
           F+F AAH L + P    K GR HGH+F V +E+T       G++ D+AEL    +     
Sbjct: 28  FSFAAAHHLANPPATENKAGRPHGHTFTVEVELTDTELRAPGFVADYAELAPVGEYLKRE 87

Query: 69  LDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-----LLSAVMV 108
           LDH  LN +   +  T++ LA+ I       +P      L AV V
Sbjct: 88  LDHRDLNALFTFD-TTTDALAQHITAWFLAHMPPERGKQLRAVRV 131


>UniRef50_A2STX2 6-pyruvoyl-tetrahydropterin synthase-like protein n=5
           Tax=Methanomicrobiales RepID=A2STX2_METLZ
          Length = 135

 Score = 93.2 bits (231), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 38/141 (26%), Positives = 62/141 (43%), Gaps = 27/141 (19%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M T ++K+  F+A+HRL H     KC RLHGH + V + + G  D  +  ++D+  +K  
Sbjct: 1   MVTRIYKETHFDASHRLMHYE--GKCSRLHGHRWSVEVWMDGTPDEKSRILLDYNIIKNI 58

Query: 62  FKPTYERLDHH-YLN-DIPGLE-------------NPTSEVLAKWIWDQVKPVV------ 100
                   DH   LN D P +E             +PTSE+LA+ I +++          
Sbjct: 59  INV----YDHQVVLNKDDPMVEALSRFQTPVLTNGDPTSELLAEDIRERLNTFCREHDLS 114

Query: 101 PLLSAVMVKETCTAGCIYRGE 121
             ++ + V E+         E
Sbjct: 115 ARVAKLRVWESEGCYAEVFAE 135


>UniRef50_B4D1V3 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Chthoniobacter flavus Ellin428 RepID=B4D1V3_9BACT
          Length = 151

 Score = 93.2 bits (231), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 37/151 (24%), Positives = 51/151 (33%), Gaps = 36/151 (23%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K    E  H L   P+  KC   HGH+  V   +          + DF  +K A
Sbjct: 1   MPYRICKTIDIENGHMLSKHPD--KCQFPHGHTRKVEFVLEAAELDRNEMVCDFKIIKDA 58

Query: 62  FKPTYERLDH----------------HYLNDIPGLEN--PTSEVLAKWIWDQVKPVV--- 100
                +  DH                 Y + + G EN  PT+EVLA+ I+D     +   
Sbjct: 59  VGQWLDTFDHALCMNTSDPAYAEFKQRYGDRVIGFENQDPTTEVLARTIFDHASKALSAY 118

Query: 101 -------------PLLSAVMVKETCTAGCIY 118
                          L  V V ET T+   Y
Sbjct: 119 SQKQDSRYPLRLDARLVTVRVWETATSWAEY 149


>UniRef50_A4CIF9 6-pyruvoyl tetrahydropterin synthase n=19 Tax=Bacteroidetes
           RepID=A4CIF9_9FLAO
          Length = 151

 Score = 92.4 bits (229), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 35/145 (24%), Positives = 56/145 (38%), Gaps = 30/145 (20%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT-----GWIIDF 55
           M    + K+FTFE  H L       KC  +HGHS+ + + + G           G ++DF
Sbjct: 1   MARVRITKEFTFETGHAL--YGYDGKCRNVHGHSYHLSVTVIGTPIAEDGAVKLGMVMDF 58

Query: 56  AELKAAFK-PTYERLDHHYL-ND------------------IPGLENPTSEVLAKWIWDQ 95
            +LK   +    +R DH  + N                   I     PTSE +      +
Sbjct: 59  GDLKKVVREEVVDRFDHATIFNRNTPHVELARTLEREGHRVILADYQPTSENMVVDFAHR 118

Query: 96  VKPVVP---LLSAVMVKETCTAGCI 117
           +   +P    L ++ ++ET TA   
Sbjct: 119 ISKRLPEHIRLHSLRLRETGTAYAE 143


>UniRef50_UPI00016C4ECA 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C4ECA
          Length = 164

 Score = 92.1 bits (228), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 36/155 (23%), Positives = 61/155 (39%), Gaps = 42/155 (27%)

Query: 3   STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              + KD   F   H + +   GH+C RLHGH++   +E+ G + P   ++ DF  LK  
Sbjct: 7   KVRVTKDHLVFCCGHFISY--RGHQCERLHGHNYRCAVEVEGPLLPDDFYVFDFIALKKR 64

Query: 62  FKPTYERLDHHYL---ND-----------------------------IPGLENPTSEVLA 89
            K   + LDHH L   N+                             +  +EN T+E++A
Sbjct: 65  TKEITDELDHHMLLATNNPVISVAPTPQCVQVRYEDREWLFPRGDCILLPIENTTAELIA 124

Query: 90  KWIWDQVKPVV-------PLLSAVMVKETCTAGCI 117
           ++I  ++   +       P +  V V+E       
Sbjct: 125 RYIAGRLWESLKTNENFTPEVLRVEVEEAPGQSAT 159


>UniRef50_Q0KAE6 6-Pyruvoyl tetrahydrobiopterin synthase protein n=5
           Tax=Burkholderiaceae RepID=Q0KAE6_RALEH
          Length = 158

 Score = 90.9 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 34/146 (23%), Positives = 61/146 (41%), Gaps = 33/146 (22%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-----PHTGWIIDFAE 57
             ++ +   F++ HR+P+     +C  +HGH + + L ++GEV         G I+DF +
Sbjct: 4   QVSITRRLEFDSGHRIPN--HCGQCRNIHGHRYRLDLTLSGEVLHREGASDDGMILDFGD 61

Query: 58  LKAAFKP-TYERLDHHY---------LNDIPGLEN---------PTSEVLAKWIWDQVKP 98
           +KA        + DH +         LN +  +E          PT E LA+  +D + P
Sbjct: 62  IKALANEHLVNKWDHAFLIYRGDTALLNFLQSMEGHKTVVLDAIPTVENLAQVAFDILAP 121

Query: 99  VVP-------LLSAVMVKETCTAGCI 117
           V          L+ +++ ET      
Sbjct: 122 VFKDCFGHHLQLTRLVLFETPNCWAE 147


>UniRef50_UPI000038E306 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=Ferroplasma
           acidarmanus fer1 RepID=UPI000038E306
          Length = 157

 Score = 90.5 bits (224), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 36/147 (24%), Positives = 57/147 (38%), Gaps = 39/147 (26%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           K  T+ + H    VP+  KC   HGH + + + I  +    +G  IDF  +K A KP  E
Sbjct: 11  KGLTWSSGHY---VPDNEKCKNFHGHDYSIDVIIDSDGVKASGMAIDFTIVKQAIKPVIE 67

Query: 68  RLDHHYL---NDIPGLENP----------------------------TSEVLAKWIWDQV 96
            +DH ++   +DI   ENP                            T+E +AK+ +D++
Sbjct: 68  NMDHKFMIPEDDIRQNENPGFIDIYVRGKYRGTMSRSDIFAFPYSADTAEFIAKYCYDKI 127

Query: 97  KPVVPLL-----SAVMVKETCTAGCIY 118
              +  L       V + E       Y
Sbjct: 128 FAKLLGLMENFRLKVTIHEGPGNMATY 154


>UniRef50_C7IE00 Putative uncharacterized protein n=1 Tax=Clostridium papyrosolvens
           DSM 2782 RepID=C7IE00_9CLOT
          Length = 154

 Score = 90.5 bits (224), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 32/151 (21%), Positives = 65/151 (43%), Gaps = 36/151 (23%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-------EVDPHTGWII 53
           M   ++ K+F+++ AH L +      C  LHGH++ ++++I+        +     G ++
Sbjct: 1   MGKISITKEFSWDMAHMLSN--HRGLCSNLHGHTYRMQVQISRKDKGVLEDTLHSDGMVM 58

Query: 54  DFAELKAAF-KPTYERLDHHYL-----NDIPGLE-----------------NPTSEVLAK 90
           DF++LKA   +   E LDH ++     ND    +                  PT+E +A 
Sbjct: 59  DFSDLKAIVQRKIIEPLDHAFMFWCDTNDSVERQIAELLKSSGKKVASVKYRPTAEEMAA 118

Query: 91  WIWDQVKPVVP----LLSAVMVKETCTAGCI 117
             +D +   +     ++  + + ET T+   
Sbjct: 119 SFFDVLTQELADSDIVVDKIKIWETTTSFAE 149


>UniRef50_Q979P1 Putative uncharacterized protein TVG1150731 n=2 Tax=Thermoplasma
           RepID=Q979P1_THEVO
          Length = 159

 Score = 90.1 bits (223), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 41/157 (26%), Positives = 63/157 (40%), Gaps = 45/157 (28%)

Query: 2   MSTTL---FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAEL 58
           M  T+   + +  F AAH +P     +KC RLHGH + + + + GE+    G +IDF EL
Sbjct: 1   MKLTVNGWYTNMRFSAAHFIPSH---YKCSRLHGHDYGIIINVDGEM--QDGMLIDFIEL 55

Query: 59  KAAFKPTYERLDHHYL---------------------ND-----------IPGLENPTSE 86
           K A +     +DH  L                     ND           I  + N TSE
Sbjct: 56  KNAIRSVINEMDHKLLVPGKANIAKYNESTNEYEISYNDKRMIIPAEYVYICDVYNTTSE 115

Query: 87  VLAKWIWDQVKPVVP-----LLSAVMVKETCTAGCIY 118
            L++++ ++V   +          V V+E    G  Y
Sbjct: 116 ELSRFVAEKVGAKIGKRKNLRSIEVSVEEGPGQGVFY 152


>UniRef50_Q0AAF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Proteobacteria
           RepID=Q0AAF2_ALHEH
          Length = 175

 Score = 89.4 bits (221), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 41/176 (23%), Positives = 59/176 (33%), Gaps = 59/176 (33%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT----GEVDPHTGWIIDFA 56
           M S T+ +    +AAHR+P    G +C  LHGH ++V          E     G ++DF 
Sbjct: 1   MSSFTVTRRVEIDAAHRIPD--HGSRCRHLHGHRYVVEAACGNPSLQEAGEERGMVLDFG 58

Query: 57  ELKAAFKPTYER-LDHHYL---NDIPGLE------------------------------- 81
            LK       +   DH  L   +D   L                                
Sbjct: 59  FLKEEMLAVIDAPCDHGLLLSVDDHVMLALLAGGSDRPEAWLEGLRERVAGQGYAEGRDP 118

Query: 82  -----------NPTSEVLAKWIWDQVKPVV-------PLLSAVMVKETCTAGCIYR 119
                       PT+EVLA+  ++++ P V         L AV V ET      Y+
Sbjct: 119 ALGGKLYLVPGPPTAEVLARHWYERLAPRVHARSRGNAALLAVTVWETPNCWARYQ 174


>UniRef50_Q3B2Y4 6-pyruvoyl tetrahydrobiopterin synthase, putative n=6
           Tax=Chlorobiaceae RepID=Q3B2Y4_PELLD
          Length = 162

 Score = 89.0 bits (220), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 38/144 (26%), Positives = 58/144 (40%), Gaps = 28/144 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV-----DPHTGWIIDFAEL 58
             + +    +  H LP+      C +LHGH  +V   + G V     D   G ++DF  L
Sbjct: 18  MQISRKIEIDYGHTLPNHFSF--CNQLHGHRGVVVATVEGPVIERSGDSEEGMVMDFRFL 75

Query: 59  KAA-FKPTYERLDHHYL---NDIPGLEN--------------PTSEVLAKWIWDQVKPVV 100
           K    +  + RLDH +     D   LE               PT+E LAKW +++++  +
Sbjct: 76  KEIMVEHIHNRLDHGFAVWREDHEDLEFILKRNTRVLVTDDPPTAEYLAKWAFNEIRTHL 135

Query: 101 PL---LSAVMVKETCTAGCIYRGE 121
           P    L  V   ET      Y G+
Sbjct: 136 PEGISLHNVRWYETPNNWADYDGQ 159


>UniRef50_Q3ATI1 6-pyruvoyl tetrahydrobiopterin synthase, putative n=6
           Tax=Chlorobium/Pelodictyon group RepID=Q3ATI1_CHLCH
          Length = 142

 Score = 87.8 bits (217), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 37/144 (25%), Positives = 59/144 (40%), Gaps = 28/144 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-----EVDPHTGWIIDFAEL 58
             + +    +  H LP+      C +LHGH  +V   + G     E     G ++DF  L
Sbjct: 1   MRISRKIEIDYGHTLPNSFSF--CNQLHGHRGVVVATVEGNIISQEQHSQQGMVMDFKFL 58

Query: 59  KAA-FKPTYERLDH------HYLNDIPGL-----------ENPTSEVLAKWIWDQVKPVV 100
           K    +  +++LDH      H   D+  +           E PT+E LA+W + Q++P +
Sbjct: 59  KDIMVEQIHDKLDHGFAVWKHDTEDLEFITRRNTRVLITDEPPTAECLARWAFHQMQPHL 118

Query: 101 P---LLSAVMVKETCTAGCIYRGE 121
           P    L  +   ET      Y GE
Sbjct: 119 PAGVTLQRIRWYETPNNWADYEGE 142


>UniRef50_A1ZSU4 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=Sphingobacteriales
           RepID=A1ZSU4_9SPHI
          Length = 158

 Score = 87.4 bits (216), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 33/139 (23%), Positives = 57/139 (41%), Gaps = 20/139 (14%)

Query: 3   STTLFKDFTFEAAHRL--PHVPE------GHKCGR--LHGHSFMVRLEITGEVDPHTGWI 52
              + +  TF A+H+L  P+  +         C     HGH+F + + + G  D  TG +
Sbjct: 1   MVYICRRETFNASHKLYNPNWSKEQNEALFGVCANQNWHGHNFELVVTVKGMPDLETGMV 60

Query: 53  IDFAELKAAF-KPTYERLDHHYLN---DIPGLENPTSEVLAKWIWDQVKPVVP------L 102
           ID+  L     +   E++ +  LN   D    + P+ E+L    W ++ P +        
Sbjct: 61  IDYKVLSKIVRREIIEKVHYKNLNLDVDFLAGKMPSCEILIIEFWKRLAPAIQQESPRTT 120

Query: 103 LSAVMVKETCTAGCIYRGE 121
           L  + + ET      Y GE
Sbjct: 121 LHHLKLVETKNNSVEYMGE 139


>UniRef50_C1VD01 PreQ(0) biosynthesis protein QueD n=1 Tax=Halogeometricum
           borinquense DSM 11551 RepID=C1VD01_9EURY
          Length = 160

 Score = 86.7 bits (214), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 28/132 (21%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           +     A HRL H     KC R HGH++ + +E+TG++    GWI+D    K       +
Sbjct: 36  RPIRISAGHRLMH--HDGKCSRPHGHNYEISVEVTGQLTDE-GWIVD----KGEVTTVID 88

Query: 68  RLDHHYLND-----IPGLE-------------NPTSEVLAKWIWDQVKPVVP---LLSAV 106
             DH +L +     +   E              PT+EV+A  + D+++  +P      AV
Sbjct: 89  EWDHRFLVETGDPLVSAFEASGDADSLVVLDAPPTAEVMAVLLEDKLRARLPDSVSDVAV 148

Query: 107 MVKETCTAGCIY 118
            V+ET      Y
Sbjct: 149 EVRETGELCASY 160


>UniRef50_Q028J7 Putative uncharacterized protein n=1 Tax=Candidatus Solibacter
           usitatus Ellin6076 RepID=Q028J7_SOLUE
          Length = 141

 Score = 86.7 bits (214), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 32/133 (24%), Positives = 50/133 (37%), Gaps = 22/133 (16%)

Query: 7   FKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDFA 56
            + + F A+HRL         +     KC     HGH+++V + + G VD  TG  +D  
Sbjct: 2   TRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDIV 61

Query: 57  ELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKP--------VVPLLS 104
            L     +   +  DH  LN ++        TSE L   I  ++K           P L 
Sbjct: 62  LLDELVRREVVQPFDHRNLNAEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKLE 121

Query: 105 AVMVKETCTAGCI 117
            + + ET      
Sbjct: 122 KIRIGETARNIFE 134


>UniRef50_C7MN71 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Coriobacteriaceae
           RepID=C7MN71_CRYCD
          Length = 146

 Score = 85.9 bits (212), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 26/137 (18%), Positives = 44/137 (32%), Gaps = 27/137 (19%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG----EVDPHTGWIIDFAELKAA 61
           L  +  F+ AH L       KC  LHGH + V   +              ++DF+  K  
Sbjct: 4   LKTESYFDGAHFLAEY--HGKCENLHGHRWRVVAILGSACLMPSGDERDMVMDFSSFKQT 61

Query: 62  FKPTYERLDHHYLND--------------------IPGLENPTSEVLAKWIWDQVKPVVP 101
            +      DH ++ +                    +      T+E  A+  + ++     
Sbjct: 62  LRDLTAAFDHTFIVEEGTLAPDTLDCLAREGFHLTMVPFR-TTAENFARHFFSKLDQAGF 120

Query: 102 LLSAVMVKETCTAGCIY 118
            +  V V ET     IY
Sbjct: 121 PVEQVEVYETPMNCAIY 137


>UniRef50_Q8TX57 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TX57_METKA
          Length = 160

 Score = 84.0 bits (207), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 32/103 (31%), Positives = 53/103 (51%), Gaps = 8/103 (7%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
             F A H +P      KCGRLHGH++ V +E+ GE     G++ DF ELK+  +   + L
Sbjct: 13  LRFSACHVIPGH---GKCGRLHGHTYHVSVELLGERTEPHGFVYDFDELKSTVRELIKPL 69

Query: 70  DHHYL----NDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV 108
           DH  L    +++  +E   +E+  + + D  + V P    V++
Sbjct: 70  DHRVLLPTESELFEIEESGNEITVR-LSDGKRYVFPREDVVLI 111


>UniRef50_C1YMA8 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Nocardiopsis
          dassonvillei subsp. dassonvillei DSM 43111
          RepID=C1YMA8_NOCDA
          Length = 174

 Score = 83.6 bits (206), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 6/91 (6%)

Query: 2  MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
          M+  +     FE AHRLPH+    KC  LHGHS+   + ++       G +++F   K A
Sbjct: 1  MTHRIRVRHNFETAHRLPHLS--GKCMNLHGHSWWAEVSVSAPALSEDGTVVEFGAFKKA 58

Query: 62 FKPTYE-RLDHHYLNDIPGLENPTSEVLAKW 91
           +   +  LDH     + G  +P + VLA+ 
Sbjct: 59 LRAFVDTHLDH---GAMLGAGDPLAAVLAEH 86


>UniRef50_Q92J44 6-carboxy-5,6,7,8-tetrahydropterin synthase n=11 Tax=Rickettsia
           RepID=QUED_RICCN
          Length = 138

 Score = 83.6 bits (206), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 28/135 (20%), Positives = 56/135 (41%), Gaps = 26/135 (19%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
            +   F+A HR+  +   +KC  LHGH +++ + I        G +IDF  +K   K   
Sbjct: 5   TRRIEFDAGHRI--IEHQNKCQFLHGHRYVLEIAIAANKTDKLGMVIDFGLIKDLAKKWI 62

Query: 67  ER-LDHHYL---NDIPGLE---------------NPTSEVLAKWIWDQVKPVVPL----- 102
           +   DH  +   +D    +               NPT+E +A  + +++ P + +     
Sbjct: 63  DENFDHSLILHQDDKEMGQQIENCTGQKIYYMQNNPTAENIATHLKNEIFPKLFVSQNFF 122

Query: 103 LSAVMVKETCTAGCI 117
           ++++ + ET      
Sbjct: 123 VTSLKLYETPNCFVE 137


>UniRef50_Q1NNT9 Putative uncharacterized protein n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NNT9_9DELT
          Length = 154

 Score = 83.2 bits (205), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 9/124 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL  + +F A HRL     G +    H H + + + + G      G+++D  EL    
Sbjct: 27  MYTLGVNRSFSARHRLIGGDWGEE-SITHAHCYRLEVALDGPELNEHGFLVDIVELAGNL 85

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSA-----VMVKETCTAG 115
               E  +   LND+P     NP+ E LA+ IW ++   +P         V V E   A 
Sbjct: 86  DLVQEAYEDRILNDLPEFAGLNPSIENLARLIWQRLS-QLPASDKLLSMSVTVWEDDQAW 144

Query: 116 CIYR 119
             ++
Sbjct: 145 ASFQ 148


>UniRef50_O27296 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=5
           Tax=Euryarchaeota RepID=QUED_METTH
          Length = 161

 Score = 83.2 bits (205), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 34/158 (21%), Positives = 58/158 (36%), Gaps = 43/158 (27%)

Query: 1   MMSTTL---FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           MM   +     +  F AAH +P   E   CG +HGHS++V +++ G+     G++ DF +
Sbjct: 3   MMKIVINGIHANLRFSAAHMIP---EHESCGCIHGHSYIVDVKVEGKRSGKHGFVADFKD 59

Query: 58  LKAAFKPTYERLDHHYL----N----------------------------DIPGLENPTS 85
           +K   +      DH  L    N                             +  LE+ ++
Sbjct: 60  VKDIVRRICSEFDHKLLIPLRNPLINFTSTTRTVKFEIAGKKYSIPEEDCCLMDLESSSA 119

Query: 86  EVLAKWIWDQVKPVVPLLS-----AVMVKETCTAGCIY 118
           E L+++    +   +          V V E    G IY
Sbjct: 120 EELSRYFAATLFKELSSKYDISSVEVCVNEGIGQGAIY 157


>UniRef50_C6MFP0 Queuosine biosynthesis protein QueD n=1 Tax=Nitrosomonas sp. AL212
           RepID=C6MFP0_9PROT
          Length = 163

 Score = 83.2 bits (205), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 31/145 (21%), Positives = 52/145 (35%), Gaps = 33/145 (22%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-----EVDPHTGWIIDFAE 57
           S  + +   F+A HR+       +C  LHGH + + + ++G     E     G ++DFA 
Sbjct: 14  SMLITRKLEFDAGHRI--STHNSQCRHLHGHRYCIEITLSGNIIADEGVAQQGMVMDFAA 71

Query: 58  LKAAFKP-TYERLDH------------HYLNDIPGLE------NPTSEVLAKWIWDQVKP 98
           +K   K    +  DH             +L  I   +       PT+E LA   ++ +  
Sbjct: 72  VKQIAKSTLVDYWDHAFLVYSGDKKVLQFLQSIEDHKTVVLDVQPTAENLALIAFNILDD 131

Query: 99  VVP-------LLSAVMVKETCTAGC 116
                      L  V + ET     
Sbjct: 132 AYQDSYGNHLQLEQVRLFETPNCWA 156


>UniRef50_A9B2M7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Herpetosiphon
           aurantiacus ATCC 23779 RepID=A9B2M7_HERA2
          Length = 165

 Score = 82.8 bits (204), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 34/157 (21%), Positives = 57/157 (36%), Gaps = 47/157 (29%)

Query: 2   MSTTLFK------DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDF 55
           MS  +++         F AAH +       KC RLHGH++ V +E+ G +     +++DF
Sbjct: 1   MSQRIYRLQVTKDQLGFAAAHFITM---RGKCERLHGHNYRVTVEVEGFLCEDQ-YVVDF 56

Query: 56  AELKAAFKPTYERLDHHYL------------ND--------------------IPGLENP 83
             LK         LDH  L            N+                    +  ++N 
Sbjct: 57  GVLKKHAAEIARTLDHRVLLAAENPKIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNT 116

Query: 84  TSEVLAKWIWDQVKPVVP-----LLSAVMVKETCTAG 115
           T+E+LA +   ++   +       L  V V  +   G
Sbjct: 117 TAELLATYFCAELCERLRQDGVDTLKMVGVWVSEGPG 153


>UniRef50_B8HQA0 Putative uncharacterized protein n=1 Tax=Cyanothece sp. PCC 7425
           RepID=B8HQA0_CYAP4
          Length = 146

 Score = 82.4 bits (203), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 36/134 (26%), Positives = 57/134 (42%), Gaps = 28/134 (20%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE-RLDH 71
           EAAHR        KC  +HGHS+ V L +  E     G +I+F +LK A++   +  LDH
Sbjct: 11  EAAHRFFQADNSLKCRSIHGHSWSVILTLKAEKLDAQGMVIEFGQLKTAWRSWLDAHLDH 70

Query: 72  HY-LNDIPGL-----------------ENPTSEVLAKWIWDQVKPVVPLLS--------- 104
              L++   L                  +PT+E LA+ + +Q + V+  L          
Sbjct: 71  TLMLHEQDPLVAVLQATDPQLRLFLLPLDPTTENLARVLAEQAERVLEQLGYFPPTVQVE 130

Query: 105 AVMVKETCTAGCIY 118
            + ++ET      Y
Sbjct: 131 RLRLEETSVNAAEY 144


>UniRef50_B2UPS6 6-pyruvoyl-tetrahydropterin synthase-like protein n=2
           Tax=Verrucomicrobia RepID=B2UPS6_AKKM8
          Length = 150

 Score = 82.4 bits (203), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 52/150 (34%), Gaps = 35/150 (23%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K    E  H L   P    C   HGH+  V +    E       ++DF  +K  
Sbjct: 1   MVYRICKSIELENGHLLSKHP--GNCKFPHGHTRSVEMVFRAETLDANDMVLDFKAVKQM 58

Query: 62  FKPTYERLDHH-YLN-DIPGL----------------ENPTSEVLAKWIWDQVKPVVP-- 101
                ++ DH   +N + P                  E+PTSEV+A+ I++  +  +   
Sbjct: 59  MGDFLQQFDHSLCVNTEDPNYAAFVAAYGERIIPFDREDPTSEVMARVIFNVARHALEKA 118

Query: 102 -------------LLSAVMVKETCTAGCIY 118
                         L  V V ET ++   Y
Sbjct: 119 RENPGEYPVRACVELERVRVWETSSSWAEY 148


>UniRef50_Q1RHI6 6-carboxy-5,6,7,8-tetrahydropterin synthase n=4 Tax=Rickettsia
           RepID=QUED_RICBR
          Length = 138

 Score = 82.0 bits (202), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 27/135 (20%), Positives = 55/135 (40%), Gaps = 26/135 (19%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
            +   F+A HR+  +   +KC  LHGH +++ + I  +     G ++DF  +K   K   
Sbjct: 5   TRRIEFDAGHRI--IGHQNKCQYLHGHRYVLEITIAAKNTDELGMVVDFGLIKDLAKGWV 62

Query: 67  ER-LDHHYL-----------------NDIPGLE-NPTSEVLAKWIWDQVKPVVPL----- 102
           +   DH  +                   +  L+ NPT+E +A  + +++ P +       
Sbjct: 63  DENFDHSLILHQGDKEIGQKIESHTGQKVYYLKNNPTAENIALHLKNEIFPKLFESQKFF 122

Query: 103 LSAVMVKETCTAGCI 117
           ++ + + ET      
Sbjct: 123 VTNIKLFETPNCFVE 137


>UniRef50_O59602 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=9
           Tax=Thermococcaceae RepID=QUED_PYRHO
          Length = 157

 Score = 82.0 bits (202), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 32/151 (21%), Positives = 57/151 (37%), Gaps = 41/151 (27%)

Query: 2   MSTTLFKDF----TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           M   + +       F+++H L  +    KC R+HGH++ V +EI GE++   G I DF  
Sbjct: 3   MRYIIKRKIYWTKEFDSSHFLE-LEYESKCKRIHGHTYKVEVEIEGELNEE-GMIFDFTH 60

Query: 58  LKAAFKPTYERLDHHYL--------------------------NDIPGLENP--TSEVLA 89
           L    K     LDH  +                          +++  ++ P  T+E LA
Sbjct: 61  LSEIVKE----LDHRLIVSKEWVKEVGDLVIIEKNRKILKVPRDEVVIIDKPNVTAEYLA 116

Query: 90  KWIWDQVKPVVPL---LSAVMVKETCTAGCI 117
           +W  +++            V + E   +   
Sbjct: 117 EWFGERIAENAGSNIKKIKVRIWEDPRSYAE 147


>UniRef50_Q6AKY1 Related to 6-pyruvoyl-tetrahydropterin synthase n=1
           Tax=Desulfotalea psychrophila RepID=Q6AKY1_DESPS
          Length = 80

 Score = 82.0 bits (202), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 29/74 (39%), Positives = 40/74 (54%), Gaps = 6/74 (8%)

Query: 51  WIIDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLS 104
             +DF  LK   K   E LDH  LN++P    +NP+SE +A +I+D + PV+      L 
Sbjct: 1   MGLDFTVLKKKTKEVIELLDHRDLNNLPYFKEKNPSSEHIAIFIFDILAPVLEHKRYSLY 60

Query: 105 AVMVKETCTAGCIY 118
           +V V ET   GC Y
Sbjct: 61  SVRVMETDNQGCTY 74


>UniRef50_D1X5B9 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Streptomyces sp. ACT-1 RepID=D1X5B9_9ACTO
          Length = 234

 Score = 82.0 bits (202), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 12/108 (11%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
            FEA H L  +P GH C R HGHS++V            G  +   E         + LD
Sbjct: 134 EFEATHHLEGLPAGHPCARRHGHSYLV------SAADADGCSVPVPE--ELAWHIGKALD 185

Query: 71  HHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
              LN+   + NPTSE LA+++ D +       + V V ET ++   Y
Sbjct: 186 GSVLNESLDI-NPTSEHLARYLSDWMDR---GPATVRVSETESSWAQY 229



 Score = 79.3 bits (195), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 34/112 (30%), Positives = 49/112 (43%), Gaps = 15/112 (13%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  + K F FEA  +L         GR  GHSF     + G      G++IDF  L A  
Sbjct: 19  SWRIGKQFRFEATRQL--------NGRADGHSFTAEAVLGGLELDPVGFVIDFGRLSALK 70

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-----LLSAVMVK 109
           +   +RLDH  LND     + + E LA ++ D  +  +P      L  V ++
Sbjct: 71  RHIDDRLDHQCLNDRVP--DASDEGLAAYLTDWARTHLPDDVAESLVDVRIR 120


>UniRef50_C0BIT7 6-pyruvoyl tetrahydropterin synthase n=6 Tax=Bacteroidetes
           RepID=C0BIT7_9BACT
          Length = 150

 Score = 81.7 bits (201), Expect = 6e-15,   Method: Composition-based stats.
 Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 30/143 (20%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT-----GWIIDFAE 57
           +  + K+F FE  H L        C  +HGHS+ + + + G           G ++DF+E
Sbjct: 4   NIRISKEFKFETGHALFGYD--GLCKNVHGHSYKLTVSLIGTPISDPNNVKFGMVMDFSE 61

Query: 58  LKAAFKP-TYERLDH-HYLND---IPGLEN---------------PTSEVLAKWIWDQVK 97
           LK        +  DH   LN       L N               PTSE++     D++K
Sbjct: 62  LKTIVNRCIVDPFDHATVLNVNSPHKELANAMESRGHKIVRVSYQPTSEMMIIDFADKIK 121

Query: 98  PVVP---LLSAVMVKETCTAGCI 117
             +P    L  ++++ET T+   
Sbjct: 122 KELPTHLGLHHLILRETETSYAE 144


>UniRef50_D1R7R7 Putative uncharacterized protein n=2 Tax=Parachlamydia
           acanthamoebae str. Hall's coccus RepID=D1R7R7_9CHLA
          Length = 143

 Score = 81.3 bits (200), Expect = 1e-14,   Method: Composition-based stats.
 Identities = 35/142 (24%), Positives = 57/142 (40%), Gaps = 27/142 (19%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M +    +   F A HR+ +    +KC   HGH++ V L          G +IDF+ LK 
Sbjct: 1   MNTVKCTRKIHFCAGHRVMNHE--NKCATAHGHNYYVHLTAEAPQLDSLGRVIDFSVLKE 58

Query: 61  AF-KPTYERLDHHYL---NDIPGLE----------------NPTSEVLAKWIWDQVKPVV 100
                  E  DH +L   +D   ++                NPT+E +A ++  +V P V
Sbjct: 59  KVGGWIDEHWDHTFLVCEHDKELIQALRSLPRKKEPFICPFNPTAEEIAIYLLREVSPKV 118

Query: 101 -----PLLSAVMVKETCTAGCI 117
                 +++ V+V ET      
Sbjct: 119 LAGSNVMITKVVVHETDNCYAE 140


>UniRef50_A9GTQ5 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9GTQ5_SORC5
          Length = 136

 Score = 80.1 bits (197), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 55/124 (44%), Gaps = 7/124 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T+        AH L  V +     RLHG ++ V +E+  E     G +++ + L+ + 
Sbjct: 1   MYTVGVRDHIMVAHSLKGV-QFGPAQRLHGATYTVSVEVEREELSPLGQVVETSALRDSL 59

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLS----AVMVKETCTAGC 116
           +     +D+  L++ P  E    T E++A++I  ++   +P+ +     + + E+     
Sbjct: 60  RAVLAEIDYRNLDEHPAFEGKRSTPELIARYIHRELGRKLPVSAGSALTITLNESPLVWV 119

Query: 117 IYRG 120
            YR 
Sbjct: 120 RYRA 123


>UniRef50_A2BJ89 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Hyperthermus butylicus
           DSM 5456 RepID=A2BJ89_HYPBU
          Length = 126

 Score = 79.0 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 15/116 (12%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERLD 70
           F AAHR+   P   +CG++HGH++ V + +           +D   L+    +  ++R D
Sbjct: 10  FSAAHRIEGHP---RCGKIHGHNYRVCIVVR----EERPLQVDLDALEEWLERNVFQRFD 62

Query: 71  HHYLNDIPGLENP------TSEVLAKWIWDQVKPVVPL-LSAVMVKETCTAGCIYR 119
           H YLN +    +       TSE LA  I D ++   P  +  V V ET      YR
Sbjct: 63  HQYLNKVLAAPDKDEKLVVTSEELAVLIADMLEQAFPGRVEYVEVCETENLCIEYR 118


>UniRef50_Q9HHN6 Vng6306c n=3 Tax=Halobacteriaceae RepID=Q9HHN6_HALSA
          Length = 150

 Score = 77.8 bits (191), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 33/126 (26%), Positives = 52/126 (41%), Gaps = 28/126 (22%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           +     A HRL H     KC R HGH++ + +EITG++    GW++D    K        
Sbjct: 25  RPIRISAGHRLQH--HDGKCSRPHGHNYEISVEITGQLTDE-GWVVD----KGTVTAVVS 77

Query: 68  RLDHHYL-----------------NDIPGLEN-PTSEVLAKWIWDQVKPVVPLL---SAV 106
             DH +L                 + +  LE  PT+EV+   +  ++   +P      +V
Sbjct: 78  DWDHRFLLEDGDPLVDAFREAGDGDAVVVLEQPPTAEVMGVVLERKLHDALPETVSAVSV 137

Query: 107 MVKETC 112
            V ET 
Sbjct: 138 TVAETP 143


>UniRef50_A1VXP3 6-pyruvoyl tetrahydrobiopterin synthase, homolog n=25
           Tax=Epsilonproteobacteria RepID=A1VXP3_CAMJJ
          Length = 193

 Score = 77.0 bits (189), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 27/142 (19%), Positives = 50/142 (35%), Gaps = 29/142 (20%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K F FE AH +           +HGHS+ V + +  +   + G + DF  LK   +
Sbjct: 1   MIIRKLFEFENAHIVRFCSSKRCKSSIHGHSYKVEVLLESKYLDNAGMVYDFGLLKTYIR 60

Query: 64  PTYERLDH----------HYLNDIPGLE--------NPTSEVLAKWIWDQVKPVVP---- 101
              +  DH           YL ++            N ++E   +  +  +  ++     
Sbjct: 61  QIIDSFDHAITLFKYDDAKYLEEMKKYSSRWICLPVNVSAENFCRVFFILIDALLKQTKM 120

Query: 102 -------LLSAVMVKETCTAGC 116
                   L +++V ET T   
Sbjct: 121 INGEQGVTLQSIIVHETRTGYA 142


>UniRef50_Q7UMI8 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=Q7UMI8_RHOBA
          Length = 175

 Score = 77.0 bits (189), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 34/146 (23%), Positives = 54/146 (36%), Gaps = 42/146 (28%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
            F F AAH +     G  C R+HGH++ VR+ + G +D    +++DF  L+ A     + 
Sbjct: 24  QFIFSAAHFITF--AGDICERIHGHNYGVRVSVEGPLD-ENRYVVDFIALRDAVLKQTQA 80

Query: 69  LDHHYL-----------------------------ND---IPGLENPTSEVLAKWIWDQV 96
           LDHH +                             N+   I  + N T+E +A+ I + V
Sbjct: 81  LDHHVILPRDHKEILVTQDETETTARFRERRWVFPNEDCIIMPVINTTAEEIARVIAENV 140

Query: 97  KPVVPLLS-------AVMVKETCTAG 115
           +               V V E     
Sbjct: 141 REQTKEQFGKALSSIEVAVDENAGQW 166


>UniRef50_Q1IAJ5 Putative 6-pyruvoyl-tetrahydropterin synthase-like n=1
           Tax=Pseudomonas entomophila L48 RepID=Q1IAJ5_PSEE4
          Length = 175

 Score = 77.0 bits (189), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 35/166 (21%), Positives = 53/166 (31%), Gaps = 52/166 (31%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP----HTGWIIDFAEL 58
              + +    +A HR+     G KC  LHGH + V +  + +        TG ++DF+  
Sbjct: 1   MFKIDRKIEIDAGHRIR--SHGSKCRNLHGHRYSVHMTCSADELATHGSETGMVLDFSFA 58

Query: 59  KAAFKPTYERL-DHHYLNDIP------------------------GLEN----------- 82
           K A     + L DH  + D                           L N           
Sbjct: 59  KDAMVQCIDELCDHALIVDAEDEYLLQVLDIHGPARDVRTSGVALPLTNGEGMKIYLVPF 118

Query: 83  -PTSEVLAKWIWDQVKPVVPLL---------SAVMVKETCTAGCIY 118
            PT+E LAK  ++ +   V  L           + V ET      Y
Sbjct: 119 SPTAEALAKHWYELLSDKVATLGHGAAQVRVDTIRVYETPNCWAEY 164


>UniRef50_C1ZCI0 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Planctomycetaceae
          RepID=C1ZCI0_PLALI
          Length = 161

 Score = 76.6 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 29/83 (34%), Positives = 45/83 (54%), Gaps = 7/83 (8%)

Query: 3  STTLFKD-FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
             + KD   F AAH +     G+ C RLHGH++ V +E+TG +D ++ ++ DF  L+ A
Sbjct: 5  RVRVTKDHLVFSAAHFITF--NGNICERLHGHNWRVAVELTGPLDENS-YVFDFIALRDA 61

Query: 62 FKPTYERLDHHYLNDIPGLENPT 84
           +     LDH  L     L++PT
Sbjct: 62 TQKLVHELDHKVL---LPLQHPT 81


>UniRef50_Q4JA84 Conserved Archaeal protein n=12 Tax=Sulfolobaceae
           RepID=Q4JA84_SULAC
          Length = 139

 Score = 76.3 bits (187), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 29/139 (20%), Positives = 55/139 (39%), Gaps = 29/139 (20%)

Query: 2   MSTTLFKD-FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELK 59
           M   +  + F+F++AH            ++HGH++ + +EI G +VD ++G++IDF  L 
Sbjct: 1   MKVVIGVEGFSFDSAHYTLSSKGND---QIHGHTYKLSVEIEGQDVDKNSGFVIDFMILT 57

Query: 60  AAFKPTYERLDHHYL------------------NDIPGLENPTSE----VLAKWIWDQVK 97
                     DH  +                    I   + PT E     +AK I+++++
Sbjct: 58  KIIHEVIREWDHKLIIPSRDARKIELKGPFKVEYKIIEEDFPTVEYIGSEIAKDIYEKLE 117

Query: 98  PVVPLLSAVMVKETCTAGC 116
                   V + E   +  
Sbjct: 118 KKFK--VRVKIYEGENSYA 134


>UniRef50_B2KCS0 Putative uncharacterized protein n=1 Tax=Elusimicrobium minutum
           Pei191 RepID=B2KCS0_ELUMP
          Length = 120

 Score = 75.9 bits (186), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 9/121 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L K  +F AAH      EG      H H+F   +++ G  +   G++ DF  ++   
Sbjct: 5   KVYLIKKSSFTAAHS----HEGMLNEAQHTHTFHYEIKLCGFTNNE-GFLTDFRIVEEDM 59

Query: 63  KPTY-ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV-PLLSAVMVKETCTAGCIYRG 120
                + L    LN    L++PT+E LA WI+ ++K     +L  V V ET  +  IY G
Sbjct: 60  NTLINKELKDKNLN--IFLKDPTTEKLAVWIFRRLKDSYGKMLHCVTVYETPQSAVIYEG 117

Query: 121 E 121
           E
Sbjct: 118 E 118


>UniRef50_C3JCW3 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=Bacteria
           RepID=C3JCW3_9PORP
          Length = 153

 Score = 75.1 bits (184), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 34/131 (25%), Positives = 50/131 (38%), Gaps = 25/131 (19%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK-AAFKPTYERLD 70
               HR+  V    KC  LHGH++ +    T       G +IDF  +K        E  D
Sbjct: 21  ISMGHRV--VGHESKCRHLHGHNYRIHFVCTAPELDALGRVIDFGVIKERLCLWVEEAWD 78

Query: 71  HHY-----------LNDIPGLE------NPTSEVLAKWIWDQVKPV-----VPLLSAVMV 108
           H             L +I   +      NPT+E +A+++ ++V P         L A  V
Sbjct: 79  HKMMLWQEDPLLPQLKEIAPEDLVIVPFNPTAEAMARYLVEEVAPHNLEGTGVTLVACTV 138

Query: 109 KETCTAGCIYR 119
           +ET      YR
Sbjct: 139 EETAKCRASYR 149


>UniRef50_A4FWS8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Methanococcus
          RepID=A4FWS8_METM5
          Length = 167

 Score = 75.1 bits (184), Expect = 7e-13,   Method: Composition-based stats.
 Identities = 22/69 (31%), Positives = 34/69 (49%), Gaps = 3/69 (4%)

Query: 6  LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
          ++    F +AH +        CG +HGHS+ V ++++GE     G++ DF  LK   K  
Sbjct: 8  IYAGLRFSSAHIVFGHDS---CGVIHGHSYYVDVKLSGEPSGEFGFVCDFKILKQIVKEL 64

Query: 66 YERLDHHYL 74
             LDH  L
Sbjct: 65 CGELDHKLL 73


>UniRef50_Q2RTB4 Putative uncharacterized protein n=1 Tax=Rhodospirillum rubrum ATCC
           11170 RepID=Q2RTB4_RHORT
          Length = 191

 Score = 73.6 bits (180), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 32/164 (19%), Positives = 52/164 (31%), Gaps = 50/164 (30%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAEL 58
              + +    +A HR+     G KC  LHGH + + + +  +        +G + DF+ L
Sbjct: 1   MFEITRKIEIDAGHRIRE--HGSKCRNLHGHRYQIHVSVRSDQLVAGGSESGMVADFSFL 58

Query: 59  KAAF-KPTYERLDHHYLND--------IPGLEN--------------------------- 82
           K           DH ++ D        + GL                             
Sbjct: 59  KELMISEIDGPCDHAFILDAEDTLYVELFGLREVAQAVRRDARAAPALSAQGSKMYVVPF 118

Query: 83  -PTSEVLAKWIWDQVKPVVPL-------LSAVMVKETCTAGCIY 118
            PT+E LA      + P+V         L+AV   ET      +
Sbjct: 119 APTAENLAAHWHALLAPLVSAHGKGGIFLAAVRAFETPNCEATF 162


>UniRef50_A0JSM2 Putative uncharacterized protein n=7 Tax=Bacteria
           RepID=A0JSM2_ARTS2
          Length = 132

 Score = 73.2 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 25/126 (19%), Positives = 44/126 (34%), Gaps = 11/126 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             +L     F  AH LP          LHG +F+  +            ++D        
Sbjct: 1   MFSLTVRRHFMIAHSLPR-EAFGPAQGLHGATFVAEVTFRRRALNDDAIVLDIGAAGGLI 59

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLL--------SAVMVKETC 112
           +     L++  L++ P    +  T+E LA++I + V   V            AV ++E  
Sbjct: 60  EEVLAGLNYKNLDEHPDFAGKLSTTEALAQYIAEAVAAKVRGSLDGRELAGLAVTLRENP 119

Query: 113 TAGCIY 118
            A   +
Sbjct: 120 DAWASF 125


>UniRef50_B2HZD9 6-pyruvoyl-tetrahydropterin synthase n=31 Tax=Proteobacteria
           RepID=B2HZD9_ACIBC
          Length = 198

 Score = 73.2 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 31/141 (21%), Positives = 54/141 (38%), Gaps = 31/141 (21%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGR-LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           + K F FE AH + +     +C R +HGHS+ V L +      H   + DF  LK   K 
Sbjct: 3   IRKLFKFENAHVVRNCTSD-RCKRSIHGHSYKVELLLKASKLDHGQMVYDFGLLKGVIKD 61

Query: 65  TYERLDH----------HYLNDIPGLE--------NPTSEVLAKWIWDQVKPVVP----- 101
            ++  DH           Y++              +P++E  ++  +   + V+      
Sbjct: 62  LFDSFDHAICFWEKDDPQYIDACKTFSARWISLPVSPSAEQFSRIFFYLAQQVLQSTVTQ 121

Query: 102 ------LLSAVMVKETCTAGC 116
                  + +V+V ET T   
Sbjct: 122 NGEGDVEVYSVIVHETDTGYA 142


>UniRef50_Q4LA59 Similar to 6-pyruvoyl tetrahydropterin synthase n=1
           Tax=Staphylococcus haemolyticus JCSC1435
           RepID=Q4LA59_STAHJ
          Length = 143

 Score = 73.2 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 5/92 (5%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE-RLDHHYLNDIPGLENPTSEVL 88
           LH HS+ + +++   +  + G  +DF E+ A +    E +L+H  +N+     N T+E +
Sbjct: 45  LHNHSYRLYVDVLSPIGDY-GLGLDFNEVDAIYNKVIEPKLNHQLINETLPDMNTTAENI 103

Query: 89  AKWIWDQVKPVVPL---LSAVMVKETCTAGCI 117
           A WIWD+ +  +P    + A+ + ET   G  
Sbjct: 104 AMWIWDEFEQHLPGEHCMYALQLFETDRHGVS 135


>UniRef50_B2RKC2 Putative uncharacterized protein n=3 Tax=Bacteria
           RepID=B2RKC2_PORG3
          Length = 139

 Score = 72.8 bits (178), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 28/130 (21%), Positives = 48/130 (36%), Gaps = 25/130 (19%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERLD 70
               HR+  V   HKC  LHGH++ +    +       G ++DF  +K    +   +  D
Sbjct: 10  ISMGHRV--VGHDHKCRHLHGHNYRIHFICSAPALDSIGRVVDFGVIKELLCQWLEDHWD 67

Query: 71  HHYL----------------NDIPGLE-NPTSEVLAKWIWD-----QVKPVVPLLSAVMV 108
           H  +                +D+  +  NPT+E +A ++ +     Q+      L    V
Sbjct: 68  HKMMLWEQDPLLPALRATVPDDLVAVPFNPTAENMAVYLTEVVGPMQLAGTGVTLIGCRV 127

Query: 109 KETCTAGCIY 118
            ET      Y
Sbjct: 128 DETRKCSASY 137


>UniRef50_D2RQ20 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RQ20_9EURY
          Length = 174

 Score = 72.4 bits (177), Expect = 4e-12,   Method: Composition-based stats.
 Identities = 29/125 (23%), Positives = 49/125 (39%), Gaps = 28/125 (22%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           +       HR+ H     KC R HGH++ V + + GE+    GW+ D  ++        +
Sbjct: 48  RPIRISTGHRIRH--HDGKCARPHGHNYEVAVTVVGELADE-GWVADKGDI----TDVID 100

Query: 68  RLDHHYLND-----IPGLE-------------NPTSEVLAKWIWDQVKPVVPLL---SAV 106
             DH +L +     I   E              PT+EV++  +  ++   +P       V
Sbjct: 101 EWDHMFLLEAGDPLIEAFEASGDSDAVVVLEHPPTAEVMSVLLERKLLAALPETVSDVRV 160

Query: 107 MVKET 111
            V ET
Sbjct: 161 QVNET 165


>UniRef50_B5I9Q5 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Aciduliprofundum
          boonei T469 RepID=B5I9Q5_9EURY
          Length = 160

 Score = 71.6 bits (175), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 29/65 (44%), Positives = 34/65 (52%), Gaps = 5/65 (7%)

Query: 10 FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
            F A+H +P     HKC RLHGH + VRL I GE   H   + DF ELK   +   E L
Sbjct: 12 LKFSASHFIPSH---HKCSRLHGHDYGVRLRIFGETKDH--ILYDFVELKNEVRSLCEEL 66

Query: 70 DHHYL 74
          DH  L
Sbjct: 67 DHKLL 71


>UniRef50_B5JFE1 Putative uncharacterized protein n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JFE1_9BACT
          Length = 149

 Score = 70.9 bits (173), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 30/134 (22%), Positives = 46/134 (34%), Gaps = 31/134 (23%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHY- 73
           AHR         C ++HGH++        E     G+++DF +LK       E LDH   
Sbjct: 14  AHR--QHRHDGHCAQIHGHNWSFTFTFGCEELDECGFVVDFGKLKPIKAWIDENLDHACV 71

Query: 74  -------LNDIPGLENP--------------TSEVLAKWIWDQVKPVV-------PLLSA 105
                  L DI  +                 +SE +A+ ++  + P V         L +
Sbjct: 72  FNEDDPLLADILAINEASGCKVYQPYVVDLCSSEGIARHVFKVINPKVKDMTGGRAFLIS 131

Query: 106 VMVKETCTAGCIYR 119
           V V E       Y 
Sbjct: 132 VEVVEDSRNSATYE 145


>UniRef50_D2R465 6-pyruvoyl tetrahydrobiopterin synthase; K01737 6-pyruvoyl
           tetrahydrobiopterin synthase n=1 Tax=Pirellula staleyi
           DSM 6068 RepID=D2R465_9PLAN
          Length = 182

 Score = 70.9 bits (173), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 35/157 (22%), Positives = 59/157 (37%), Gaps = 47/157 (29%)

Query: 3   STTLFKDFT-FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              L K+   F AAH +     G+ C  LHGH++ V +EI   +D +  ++IDF  ++  
Sbjct: 18  RIRLEKEAHVFAAAHFITF--AGNICEPLHGHNYGVAVEIEAPLDENQ-YVIDFIAVRDE 74

Query: 62  FKPTYERLDHHYL------------ND--------------------IPGLENPTSEVLA 89
                + LDH  L            ++                    +  L N TSE+LA
Sbjct: 75  LTAITQTLDHRMLLPTSHPLIQVTADEREVTARFGDKRWVFPRTDCVLLPLTNTTSELLA 134

Query: 90  KWI----WDQVKPVVPLLS-------AVMVKETCTAG 115
           ++I     +++   +P          +V V E     
Sbjct: 135 RYIGLALRERLAARLPAQVVGSITRFSVEVDENHGQR 171


>UniRef50_D0MWX1 Putative uncharacterized protein n=2 Tax=Phytophthora infestans
           T30-4 RepID=D0MWX1_PHYIN
          Length = 244

 Score = 70.9 bits (173), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 34/160 (21%), Positives = 59/160 (36%), Gaps = 47/160 (29%)

Query: 3   STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              + KD+  F AAH + +     K   LHGH++ + + ITG+V P  G+++DF E+K  
Sbjct: 84  KVHVSKDYMKFNAAHFIAYKGFREK---LHGHNYRLAVTITGQVGPD-GYVVDFGEIKKI 139

Query: 62  FKPTYERLD---------------------HHYLNDIPGLENP------------TSEVL 88
            +   + L+                     H    D+     P            ++E L
Sbjct: 140 SRVICKDLNESFLVPMNSDALKISFDGTNVHILTEDMAKFSFPKADCSLLPIVHSSAEEL 199

Query: 89  AKWIWDQVKPVVPLLS---------AVMVKETCTAGCIYR 119
           A +I +Q+     L++          V + E       Y 
Sbjct: 200 AIYISNQLIDAFTLVALLDRGVRKIEVSISEANQQFASYE 239


>UniRef50_Q6L053 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=Picrophilus torridus
           RepID=Q6L053_PICTO
          Length = 144

 Score = 70.5 bits (172), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 34/137 (24%), Positives = 57/137 (41%), Gaps = 30/137 (21%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH---TGWIIDFAELKAAFK 63
            +   + AAH +P  P   KCGRLHGH +++ + +  + +      G+ ID+ ++K A K
Sbjct: 9   TRGLHWSAAHIIPGHP---KCGRLHGHDYILNIRLYFDENNSLKTRGYEIDYGDIKRAAK 65

Query: 64  PTYERLDHHYL--------------NDIP---------GLENPTSEVLAKWIWDQVKPVV 100
              ER+DHH++              N+I           +   +SE LA +I  ++    
Sbjct: 66  AIIERMDHHFMVPEDAIEDNGKIHYNNITVSADQVCRIPVPVVSSENLAIYIKSELNRYF 125

Query: 101 PLLS-AVMVKETCTAGC 116
                   V E    G 
Sbjct: 126 SEYKIECGVFEGEGQGA 142


>UniRef50_B6KR79 Putative uncharacterized protein n=3 Tax=Toxoplasma gondii
           RepID=B6KR79_TOXGO
          Length = 475

 Score = 70.1 bits (171), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 31/154 (20%), Positives = 55/154 (35%), Gaps = 46/154 (29%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
             F   H + +        RLHGH++ V ++I G V P  G+I+DF ++K   +   + L
Sbjct: 325 MKFNCGHFIAYRGFR---ERLHGHNYSVTVKIGGIVGPD-GYILDFGDIKQTAREVCKSL 380

Query: 70  DHHYL----NDIPG-----------------LENP------------TSEVLAKWIWD-- 94
           D H +    +D+                    + P            ++E +  ++W   
Sbjct: 381 DEHLIVPMKSDVLDITQEGQSIIIRCEDGAEFKVPCSDCKCLPIVHSSAEEITCYLWQCI 440

Query: 95  -------QVKPVVPLLSAVMVKETCTAGCIYRGE 121
                   +K        V V ET +    +R E
Sbjct: 441 VDKVTVPLLKKRGATWVEVAVWETPSQMASFRRE 474


>UniRef50_Q4JIS7 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=uncultured
           bacterium BAC10-4 RepID=Q4JIS7_9BACT
          Length = 162

 Score = 70.1 bits (171), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 30/139 (21%), Positives = 55/139 (39%), Gaps = 43/139 (30%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           F   H + +      C  LHGH++  R+E+ G++D +  ++ DF  LK   +   + +DH
Sbjct: 15  FACGHFITY---EGSCETLHGHNYRARVELEGDLDENY-YVWDFVSLKRLMRRLVDEMDH 70

Query: 72  HYL----N----------------------------DIPGLENPTSEVLAKWIWDQVKPV 99
             L    N                                + N T+E+LA+++  +V+  
Sbjct: 71  RMLLPLQNPALTLREEDGHVHVLYKDRRYVFPKQDVAFLPIPNTTAEMLARYLLGRVRDE 130

Query: 100 VPLLS-------AVMVKET 111
           +  L        AV V+E+
Sbjct: 131 LRKLGGGRLKALAVEVEES 149


>UniRef50_D1W1T6 Conserved domain protein (Fragment) n=4 Tax=Bacteria
          RepID=D1W1T6_9BACT
          Length = 70

 Score = 69.7 bits (170), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 22/74 (29%), Positives = 37/74 (50%), Gaps = 5/74 (6%)

Query: 2  MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEI-TGEVDPHTGWIIDFAELKA 60
          M   + K     AAHRL  +    KC  LHGH++++ + +   +     G + DF  +K 
Sbjct: 1  MIYCVSKRMEISAAHRL-SLSYESKCQCLHGHNWIITVYLFKKDKLNGDGMVFDFTHIKK 59

Query: 61 AFKPTYERLDHHYL 74
          A    +++LDH Y+
Sbjct: 60 A---IHDQLDHAYI 70


>UniRef50_A0RWH6 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Archaea
           RepID=A0RWH6_CENSY
          Length = 270

 Score = 69.7 bits (170), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 24/66 (36%), Positives = 35/66 (53%), Gaps = 5/66 (7%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           + FTF+ AH LP V    KC  LHGH+  V +E+ G++    G ++DF + K   K    
Sbjct: 123 QSFTFDYAHVLPLVD---KCSVLHGHTSSVMVELAGQM--KDGMLVDFGKAKGIIKQAIS 177

Query: 68  RLDHHY 73
             DH +
Sbjct: 178 SFDHKF 183


>UniRef50_UPI0001AF6FD6 hypothetical protein MkanA1_23688 n=1 Tax=Mycobacterium kansasii
           ATCC 12478 RepID=UPI0001AF6FD6
          Length = 146

 Score = 69.3 bits (169), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 33/129 (25%), Positives = 53/129 (41%), Gaps = 24/129 (18%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT-GEVDPHTGWIIDFAELKA 60
           MS T+ K F F+A HR        K   +HGH++ +RL +  G+       + D  EL  
Sbjct: 1   MSHTIEKTFRFDAGHRSLGFNY-KKEETIHGHTWQLRLILEYGDQLDDMKTVFDTNELAV 59

Query: 61  AFKPTYERLDHHYL--------NDIPGL--------------ENPTSEVLAKWIWDQVKP 98
             +P    LDH ++        +D   +               NPT E L + I+++V  
Sbjct: 60  IVEPIISDLDHSFIIWDQDPIYDDFLKVCELADVADKVYTVDFNPTIEGLVEHIYERVNS 119

Query: 99  VVPLLSAVM 107
            + L   V+
Sbjct: 120 QLRLSGCVL 128


>UniRef50_C6KTB6 6-pyruvoyltetrahydropterin synthase n=6 Tax=Plasmodium
          RepID=C6KTB6_PLAF7
          Length = 173

 Score = 68.2 bits (166), Expect = 9e-11,   Method: Composition-based stats.
 Identities = 26/77 (33%), Positives = 41/77 (53%), Gaps = 8/77 (10%)

Query: 10 FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
          F+F  AH + +         LHGH++ V L++ G V    G++IDF+ LK   K    +L
Sbjct: 23 FSFNCAHFIAYNGFR---ETLHGHNYNVSLKVRGYV-RDDGYVIDFSILKEKVKKVCNKL 78

Query: 70 DHHYL----NDIPGLEN 82
          DHH++    +D+   EN
Sbjct: 79 DHHFILPIYSDVLKFEN 95


>UniRef50_B9LV86 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Halorubrum
           lacusprofundi ATCC 49239 RepID=B9LV86_HALLT
          Length = 153

 Score = 67.8 bits (165), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 29/130 (22%), Positives = 52/130 (40%), Gaps = 28/130 (21%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
               + HR+ H     KC R HGH++ + +E+TG++    GW++D  +         +  
Sbjct: 31  IRISSGHRILHHE--GKCSRPHGHNYEITVEVTGQLTEE-GWVVDKGD----VTDVIDAW 83

Query: 70  DHHYLND-----IPGLE-------------NPTSEVLAKWIWDQVKPVVPLL---SAVMV 108
           DH +L +     +   E              PT+EV++  +  ++    P      +V V
Sbjct: 84  DHRFLVEEGDPLVDAFEASGDSDALVVLDHPPTAEVMSVLLEQRMLDAFPDTVSDVSVSV 143

Query: 109 KETCTAGCIY 118
            ET      Y
Sbjct: 144 SETGELCASY 153


>UniRef50_Q1D8H8 Putative uncharacterized protein n=1 Tax=Myxococcus xanthus DK 1622
           RepID=Q1D8H8_MYXXD
          Length = 209

 Score = 67.0 bits (163), Expect = 2e-10,   Method: Composition-based stats.
 Identities = 28/106 (26%), Positives = 51/106 (48%), Gaps = 7/106 (6%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
            F+A+H +   P+G +   LH H + VR+ +      H   IIDF +L+         L 
Sbjct: 92  EFKASHAVT-FPDGQR-EPLHTHDWWVRVWVKARALNHWDVIIDFKDLQDIIVRVCRELH 149

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP---LLSAVMVKET 111
              +N+ P  +  N T+E + ++++ QV+  +P    L  V ++ T
Sbjct: 150 DTNINEHPYFKTVNCTAERVTEYVFKQVESGLPEGVTLDRVHLRRT 195


>UniRef50_A9KBA1 Queuosine biosynthesis protein n=7 Tax=Gammaproteobacteria
           RepID=A9KBA1_COXBN
          Length = 184

 Score = 66.2 bits (161), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 29/144 (20%), Positives = 49/144 (34%), Gaps = 32/144 (22%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + +    +  HR+    E  KC  +HGH   V +          G+ IDF E+K  
Sbjct: 1   MKQYISRRVEIDLGHRVMD--ERFKCYSIHGHRASVHMTFEFSNQSEIGYCIDFKEIKRV 58

Query: 62  -FKPTYERLDHHY------------------------LNDIPGLENPTSEVLAKWIW--- 93
             +   ++ DH +                        LN      NPT+E +++ I+   
Sbjct: 59  GAQWIDDKFDHGFAANPKDKFVIEACQKTNSKYYLMSLNGKDNYCNPTAENISREIFLAL 118

Query: 94  DQVKPVVPLL--SAVMVKETCTAG 115
           + +    P L    +   ET    
Sbjct: 119 EILFEDYPGLKIHRLRFYETPNCW 142


>UniRef50_B8C0F3 Predicted protein n=1 Tax=Thalassiosira pseudonana
           RepID=B8C0F3_THAPS
          Length = 192

 Score = 65.9 bits (160), Expect = 4e-10,   Method: Composition-based stats.
 Identities = 25/121 (20%), Positives = 43/121 (35%), Gaps = 16/121 (13%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAFKPTYERLDHHY 73
           AH     P     G LHG ++ V +E           W+ID     A         ++  
Sbjct: 70  AHSFHSHPSFGPAGGLHGATYTVDVEFASSTLHKECNWVIDIGVASAMVAEVLTEYNYKN 129

Query: 74  LNDIPGLEN--PTSEVLAKWIWDQVKPVVPLLS------------AVMVKETCTAGCIYR 119
           L+++ G +N   T+E + + I+D V   +                 V + E+  A   + 
Sbjct: 130 LDEVFG-DNVMTTTEFMCRAIFDGVVKKLKERYSDIDVDHFEGWIKVTLWESHKAWGSFE 188

Query: 120 G 120
           G
Sbjct: 189 G 189


>UniRef50_A4TYV7 Putative uncharacterized protein n=1 Tax=Magnetospirillum
           gryphiswaldense RepID=A4TYV7_9PROT
          Length = 176

 Score = 65.1 bits (158), Expect = 7e-10,   Method: Composition-based stats.
 Identities = 34/172 (19%), Positives = 50/172 (29%), Gaps = 59/172 (34%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAELK 59
             + +    +A HR+     G KC  +HGH + +          H G     ++DF  LK
Sbjct: 5   YRISRRIDIDAGHRIM--THGSKCRHVHGHRYGIEAVCEAVDLHHDGEQTDMVLDFGFLK 62

Query: 60  AAF-KPTYERLDHHY---LNDIPGLE---------------------------------- 81
               K   E  DH +   L D+  L                                   
Sbjct: 63  EEMLKAIDEPCDHGFIAALADVELLTMFTPLGGDTAEWLADLEAQVREKGEATTTRTRLL 122

Query: 82  --------NPTSEVLAKWIWDQVKPVV-------PLLSAVMVKETCTAGCIY 118
                    PT+E LA+  + ++   V         L  V V ET      Y
Sbjct: 123 TKLTVVPFQPTAECLARHWFIKLAEPVKQRSGGAARLLLVRVFETPNCAAEY 174


>UniRef50_B0R4P7 6-pyruvoyltetrahydropterin synthase n=4 Tax=Halobacteriaceae
           RepID=B0R4P7_HALS3
          Length = 135

 Score = 63.6 bits (154), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 29/118 (24%), Positives = 41/118 (34%), Gaps = 7/118 (5%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           L     F A H L  VP     G +H H F   +   G      G+++D   + A     
Sbjct: 13  LTVRREFIAQHYLT-VPNPGPEGEVHSHRFTADVTFAGGELDEHGYLVDIDAVDAVLDDI 71

Query: 66  YERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCI 117
             R     LND       NP+ E  A+ I D++   +    P    V + E   A   
Sbjct: 72  EARYQDTLLNDHAEFGDANPSLERFAELIGDRIADGLGAAAPTRLTVRLWEDDLAWAS 129


>UniRef50_B7FYC8 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FYC8_PHATR
          Length = 157

 Score = 63.2 bits (153), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 23/115 (20%), Positives = 46/115 (40%), Gaps = 9/115 (7%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGE-VDPHTGWIIDFAELKAAFKPTYERLDHHY 73
           AH     P     G +HG ++   +E + + +DP T W++D  +          + +   
Sbjct: 39  AHSFHRHPAFGPAGGMHGATYTCDVEFSKDTLDPDTNWVMDIGKASELLCTVLAKYNLKN 98

Query: 74  LNDI-PGLENPTSEVLAKWIWDQVKPVVP-------LLSAVMVKETCTAGCIYRG 120
           L+++ P  +  T+E + K I   +  ++            V + E+  A   Y G
Sbjct: 99  LDEVFPNGQLTTTEFMCKQIHMDLVDLIRREFHDFHGEVCVKLWESHKAWAAYSG 153


>UniRef50_Q18HJ5 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n=3 Tax=cellular
           organisms RepID=Q18HJ5_HALWD
          Length = 134

 Score = 63.2 bits (153), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 30/124 (24%), Positives = 47/124 (37%), Gaps = 9/124 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  L     F A H L         G++H H F V L   G+     G++++   +++  
Sbjct: 6   SYELAVQRDFIAQHVLTVPDPEPPEGQIHSHHFEVELHFAGDSLGEYGYLLNIVTVESIL 65

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV-------PLLSAVMVKETCT 113
           +   ER     LND+P  E  NP+ E  ++   D V   +       P    V + E   
Sbjct: 66  EDLVERYRDSVLNDLPEFEGLNPSVENFSRIFGDHVAERLSVAGETTPDQLRVQIWEDDA 125

Query: 114 AGCI 117
           A   
Sbjct: 126 AWAS 129


>UniRef50_P80081 6-pyruvoyl tetrahydrobiopterin synthase (Fragments) n=1 Tax=Salmo
           salar RepID=PTPS_SALSA
          Length = 103

 Score = 62.8 bits (152), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 27/120 (22%), Positives = 44/120 (36%), Gaps = 35/120 (29%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
            + +  +F A+HRL              HS                 +++   +K   + 
Sbjct: 16  YITRVQSFCASHRL--------------HS--------------PTLVMNITNIKEHIEE 47

Query: 65  TYERLDHHYLN-DIPGLENPTSEVLAKWIWDQVKPVVPL--LSAVMVKETCTAGCIYRGE 121
               LDH  L+ D+P   N     +A +I D +   +P   L  V + ET     +YRGE
Sbjct: 48  VI-PLDHKNLDKDVPYFANV---NVAVYIXDNMVKQLPANLLYEVKIHETDKNIVVYRGE 103


>UniRef50_C9ZBP0 Putative uncharacterized protein n=2 Tax=Streptomyces
           RepID=C9ZBP0_STRSW
          Length = 147

 Score = 62.8 bits (152), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 24/129 (18%), Positives = 41/129 (31%), Gaps = 14/129 (10%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
            ++        AH            RLHG +F+V              ++D         
Sbjct: 17  FSITVRDHIMIAHSFRG-EVFGPAQRLHGATFLVDATFRRAELDDDNIVVDIGLATQELG 75

Query: 64  PTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV--PLLSA---------VMVKE 110
                L++  L++ P     N ++E LAK I D++   +    L           V + E
Sbjct: 76  AVVSELNYRNLDNEPAFAHTNTSTEFLAKVIADRLAERIHKGALGENAKGIAGIQVTLHE 135

Query: 111 TCTAGCIYR 119
           +  A   Y 
Sbjct: 136 SHIAWASYE 144


>UniRef50_D2EHH0 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Pediococcus
           acidilactici 7_4 RepID=D2EHH0_PEDAC
          Length = 123

 Score = 62.8 bits (152), Expect = 3e-09,   Method: Composition-based stats.
 Identities = 25/107 (23%), Positives = 48/107 (44%), Gaps = 13/107 (12%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHH 72
            A+H +       K    H H++ V  EI  +       I+ F +++   +         
Sbjct: 14  NASHAMRWKDGEGK---QHNHTWEVVCEIKSK---DDHMIV-FRDIEKKIQDVLGSFSGQ 66

Query: 73  YLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAVMVK----ETCT 113
           +LN++P  +  NPT E +  W++D +  ++  LSA +V+    E+ T
Sbjct: 67  FLNELPYFKEINPTVENVTIWLFDLLSSILEELSAKLVRIEVGESPT 113


>UniRef50_A9LH53 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=uncultured
           planctomycete 13FN RepID=A9LH53_9BACT
          Length = 164

 Score = 62.4 bits (151), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 33/138 (23%), Positives = 52/138 (37%), Gaps = 27/138 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K + F AAHR  +     KC  LHGH + V+     E D     +  F +  A  +
Sbjct: 1   MIIQKQYKFYAAHR--NETLQDKCSNLHGHRYGVKCHFQVERDGDISTL--FGDFDAKVE 56

Query: 64  PTYER-LDHHYL-NDIPG--------------------LENPTS-EVLAKWIWDQVKPVV 100
           P  ++  DH  L N                         + PTS E L   ++ ++  + 
Sbjct: 57  PWLKQNYDHGMLINRHDSLYESLEMHMERTGESLRLNVFDGPTSVENLCHKLFTEITQLG 116

Query: 101 PLLSAVMVKETCTAGCIY 118
             L+ + V+ET T    Y
Sbjct: 117 FRLATLEVQETDTFVVSY 134


>UniRef50_Q0AV03 6-pyruvoyl-tetrahydropterin synthase related domain; conserved
           membrane protein n=1 Tax=Syntrophomonas wolfei subsp.
           wolfei str. Goettingen RepID=Q0AV03_SYNWW
          Length = 1166

 Score = 62.0 bits (150), Expect = 6e-09,   Method: Composition-based stats.
 Identities = 27/109 (24%), Positives = 47/109 (43%), Gaps = 11/109 (10%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHH 72
            A H    V  G   G +H HS+ V  E+  +V    G  I+F+ +  A        ++ 
Sbjct: 170 NARHF---VIFGGTTGPVHAHSWQVETEV--DVPREIGDTIEFSRVSQAVSAALGPYENT 224

Query: 73  YLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAG 115
            LN +   +   PT+E +A + +++V   +      L  + + ET T G
Sbjct: 225 ILNQVHPFDLIQPTTENIAMYFFNRVDEYLAKLGLKLYQLSLWETPTRG 273


>UniRef50_B6IVH4 6-pyruvoyl tetrahydropterin synthase, putative n=16 Tax=Bacteria
           RepID=B6IVH4_RHOCS
          Length = 133

 Score = 61.2 bits (148), Expect = 8e-09,   Method: Composition-based stats.
 Identities = 23/109 (21%), Positives = 40/109 (36%), Gaps = 13/109 (11%)

Query: 25  HKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGL--EN 82
                LHG +F+V  E         G ++D     A  K     L +  L+ +P     N
Sbjct: 22  GPAQELHGATFLVDAEFRRPSLSADGLVVDIGLASALLKEVLAPLTYRNLDGLPDFRGRN 81

Query: 83  PTSEVLAKWIWDQVKPVVPLLS-----------AVMVKETCTAGCIYRG 120
            T+E LA  I+ +++  +   +            V + E+  A   + G
Sbjct: 82  TTTEFLAGEIFRRLRARIADGALGDDGRALVGLRVELHESHVARAAFEG 130


>UniRef50_Q9ZKR8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=14 Tax=Helicobacter
           RepID=QUED_HELPJ
          Length = 200

 Score = 61.2 bits (148), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 16/99 (16%), Positives = 33/99 (33%), Gaps = 17/99 (17%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + + + F A+H + +         +HGH++ V + I      +    +DF  ++   +
Sbjct: 1   MVIRRLYKFCASHVVRNCSSLKCAQNIHGHNYEVEVFIETNRLDNANMALDFGLMQQEMQ 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL 102
              +  DH                 A   WD+  P    
Sbjct: 61  TFIDSFDH-----------------AHHFWDKESPEFQR 82


>UniRef50_D1B474 Putative uncharacterized protein n=3 Tax=Campylobacterales
           RepID=D1B474_SULD5
          Length = 180

 Score = 61.2 bits (148), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 31/176 (17%), Positives = 51/176 (28%), Gaps = 61/176 (34%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHK--------CGRLHGHSFMVRLEITGEVDPHTGWII 53
           M   + K+F F   HR+       +        C  LHGH   + + +        G + 
Sbjct: 1   MLWQISKEFDFCYGHRVWSQQLDSEFSLTGCLACRHLHGHQGKIVVYLQSNEL-KNGMVT 59

Query: 54  DFAELKAAFKPTYERLDHHYLNDI---------PGLEN---------------------- 82
           DF  L    +     LDH ++ DI         P   +                      
Sbjct: 60  DFHHLNWFKQFLDATLDHKFIIDIHDPLFETLLPHFADKQNLLSHEAGYQTPDLSKVAHE 119

Query: 83  -----------------PTSEVLAKWIWDQVKPVVPLLSA----VMVKETCTAGCI 117
                            PTSE ++ W+ + ++  +  L      V   ET  +  I
Sbjct: 120 AMHLIEMYEGYIIVDFVPTSENISTWLLEIIQKKMSRLGVKVSHVEFLETPKSRSI 175


>UniRef50_B6R1Q6 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R1Q6_9RHOB
          Length = 139

 Score = 61.2 bits (148), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 27/119 (22%), Positives = 40/119 (33%), Gaps = 14/119 (11%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
           AH L          +LHG +  V + I  E     G +ID               ++  L
Sbjct: 13  AHSLKG-EVFGPASQLHGLTAHVHVAIFAEELDENGIVIDIGNALDVLAEILHPFNYKNL 71

Query: 75  NDIPGLE--NPTSEVLAKWIWDQVKPVV---------PLLSAVMV--KETCTAGCIYRG 120
           +D+P  +  N T + L  +I+ +V               LS V V   E   A   Y  
Sbjct: 72  DDLPQFKGRNTTVDFLCSYIYQRVCDAAYLHKLGREPGELSKVRVTISENPNARASYEA 130


>UniRef50_Q58668 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=4
           Tax=Methanocaldococcus RepID=QUED_METJA
          Length = 163

 Score = 61.2 bits (148), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 32/149 (21%), Positives = 53/149 (35%), Gaps = 42/149 (28%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
             F +AH +   P    CG +HGHS+ V +++ GE      ++ DF  +K   K   + L
Sbjct: 12  LRFSSAHIVFGHPT---CGVIHGHSYYVDVKLYGERAGDFKFVCDFKIIKKIVKEICDEL 68

Query: 70  DHHY------------LND--------------------IPGLENPTSEVLAKWIWDQVK 97
           DH              L D                    +  + + T+E LA +  +++ 
Sbjct: 69  DHKLILPKNHEHVYYELRDKTLYFKYENKEYSIPVEDVILLPIPSTTAEDLAIYFANEIA 128

Query: 98  PVVPLLS-------AVMVKETCTAGCIYR 119
             +  L         V + E    G  YR
Sbjct: 129 DRLKNLGFSNINWIEVSINEGIGQGACYR 157


>UniRef50_Q1LPD9 6-pyruvoyl-tetrahydropterin synthase-like protein n=4
           Tax=Proteobacteria RepID=Q1LPD9_RALME
          Length = 193

 Score = 60.9 bits (147), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 31/145 (21%), Positives = 49/145 (33%), Gaps = 29/145 (20%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           + K F FE AH +           +HGHS+ + L +      H   + DF  LK      
Sbjct: 9   IRKLFRFENAHIVRGCSTRRCSHSIHGHSYKIELLLEAHSLDHGQMVYDFGLLKGGAFTL 68

Query: 66  YERLDH----------HYLNDIPGLE--------NPTSEVLAKWIWDQVKPVVP------ 101
            +  DH           YL  +            +P++E  ++  +  V  V+       
Sbjct: 69  IDAFDHAVTLWTGDDPAYLAAMRQHSERWVLIPVSPSAEQFSRLFFLLVDAVLATTALRN 128

Query: 102 -----LLSAVMVKETCTAGCIYRGE 121
                 L +V+V ET T       E
Sbjct: 129 GEGDVRLHSVIVHETETGYAQCFRE 153


>UniRef50_D0LLG1 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Haliangium ochraceum
           DSM 14365 RepID=D0LLG1_HALO1
          Length = 128

 Score = 60.9 bits (147), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 18/92 (19%), Positives = 39/92 (42%), Gaps = 6/92 (6%)

Query: 34  SFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEVLAKW 91
           ++ V      E       ++DF   + A       +++  L+++P L  +N T+E L ++
Sbjct: 31  TYEVEAVFIVEELDENNLVVDFGASQQALTAIIGTMNYKNLDELPELNGKNTTTEFLCRY 90

Query: 92  IWDQVKPVVPLLS----AVMVKETCTAGCIYR 119
           I + +   V  L      + ++E+  A   Y 
Sbjct: 91  IHEYMSKAVEDLFSGTLRITMRESTVAEVSYE 122


>UniRef50_B9Z9U9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Halobacteriaceae
          RepID=B9Z9U9_NATMA
          Length = 159

 Score = 60.1 bits (145), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 18/67 (26%), Positives = 30/67 (44%), Gaps = 7/67 (10%)

Query: 8  KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
          +       HR+ H     KC R HGH++ V + + G +    GW+ D  ++ A      +
Sbjct: 33 RPIRISTGHRILH--HDGKCARPHGHNYEVSVTVEGTLTEE-GWVADKGDITA----VID 85

Query: 68 RLDHHYL 74
            DH +L
Sbjct: 86 EWDHKFL 92


>UniRef50_UPI0001AF6FD4 hypothetical protein MkanA1_23678 n=2 Tax=Mycobacterium kansasii
           ATCC 12478 RepID=UPI0001AF6FD4
          Length = 165

 Score = 60.1 bits (145), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 36/163 (22%), Positives = 62/163 (38%), Gaps = 43/163 (26%)

Query: 2   MSTTLFKDFTFEAAHRL--PHVPE-------------GHKCGRLHGHSFMVRLEITGEVD 46
           M  T+ + F  E  HR    H+P               +KC  +HGH+  V + + G+  
Sbjct: 1   MPYTIKQTFRVEIGHRTWSHHMPTSRGGSEFYTPDLIANKCANIHGHTIFVSVTLVGDSL 60

Query: 47  PHTGWIIDFAELKAAFKPTYERLDHHYLND--IPGLEN------------------PTSE 86
               +++D   L+ AF+P  +  D  ++ D   P  E+                  PT E
Sbjct: 61  DEQYFLLDTDLLEQAFRPILDEFDFAFVVDRHDPLYEDIAAVVHKGGLKLCTVDFSPTFE 120

Query: 87  VLAKWIWDQVKPVVPLL---SAVMVKETC-----TAGCIYRGE 121
            L +  +D+++ V+        + +KE       T    Y GE
Sbjct: 121 GLVRHFYDRLQAVIAEKGLADQLRIKEMKVLGELTVEATYSGE 163


>UniRef50_A9G7Q3 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9G7Q3_SORC5
          Length = 106

 Score = 59.7 bits (144), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 19/103 (18%), Positives = 44/103 (42%), Gaps = 13/103 (12%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEV 87
           +HG ++ V +EI  +       ++D   L A+ +   + +D+  L++ P       T+E 
Sbjct: 1   MHGATYSVEIEIRAKALGPHHVVMDIGALHASLRRVLDTIDYTNLDEHPAFPGRTSTTER 60

Query: 88  LAKWIWDQVKPVVPLL-----------SAVMVKETCTAGCIYR 119
           +A+ +   +   +  L             V+V+E+ +A   + 
Sbjct: 61  VAEHVAGLLAEEIARLPAAEAPLPGSTLRVLVRESPSAYAGFE 103


>UniRef50_C5SEY8 Putative uncharacterized protein n=1 Tax=Asticcacaulis excentricus
           CB 48 RepID=C5SEY8_9CAUL
          Length = 185

 Score = 59.7 bits (144), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 29/148 (19%), Positives = 50/148 (33%), Gaps = 35/148 (23%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-----HTGWIIDFA 56
           M     +   F  AHRL       KC   HGH+  VR+ +  +         + +   F 
Sbjct: 1   MQIQFTRR--FSMAHRLR-ADRSSKCATPHGHNEFVRVSLKAKSPDTVKWGQSNYAQSFD 57

Query: 57  ELKAAFKPTYER-LDHHY-LNDIPGL-------------------ENPTSEVLAKWIWDQ 95
            LK  +    +  LDH + L     L                    +PT+E +A  ++ +
Sbjct: 58  ALKRDWHRFVDEALDHAFQLGADDPLIGFFQAHEPDLLPRLLIIPGDPTTEAVALALYHK 117

Query: 96  VKPVVPL------LSAVMVKETCTAGCI 117
           +  ++             ++ET T   I
Sbjct: 118 LNAILSAQVPDFECVRFEIEETPTNTVI 145


>UniRef50_Q19Z82 Gp4 n=2 Tax=unclassified Siphoviridae RepID=Q19Z82_9CAUD
          Length = 143

 Score = 58.9 bits (142), Expect = 4e-08,   Method: Composition-based stats.
 Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 4/71 (5%)

Query: 6  LFKDFTFEAAHRLPHV-PEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK- 63
          L     F A HR+P +   G KC   HGH+F V           + +  +FAE K   + 
Sbjct: 7  LTVKHHFSAGHRIPGLAGAGGKCATPHGHTFGVEWTFQVSSLDASEF--EFAEAKKLLRG 64

Query: 64 PTYERLDHHYL 74
             E LDH +L
Sbjct: 65 WVDEHLDHGFL 75


>UniRef50_Q4A0G7 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Staphylococcus saprophyticus subsp. saprophyticus
           ATCC 15305 RepID=Q4A0G7_STAS1
          Length = 142

 Score = 58.2 bits (140), Expect = 8e-08,   Method: Composition-based stats.
 Identities = 23/86 (26%), Positives = 39/86 (45%), Gaps = 5/86 (5%)

Query: 34  SFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERLDHHYLNDIPGLENPTSEVLAKWI 92
           ++   +EI   +D + G  +DF E+   + +     +D   +N+     N T+E +A WI
Sbjct: 48  TYKFNIEILSSIDAY-GLAMDFNEVDKLYEREIAPYIDGQLVNETLPEMNTTAENIAIWI 106

Query: 93  WDQVKPVVPL---LSAVMVKETCTAG 115
           W Q    +P    L  +   ET T G
Sbjct: 107 WHQFNKHLPENNSLQKLEFFETDTQG 132


>UniRef50_A7IHR5 Putative uncharacterized protein n=4 Tax=Bacteria
           RepID=A7IHR5_XANP2
          Length = 159

 Score = 57.8 bits (139), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 24/120 (20%), Positives = 45/120 (37%), Gaps = 14/120 (11%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
           AH             LHG +F+V +          G ++D      A K     L++  L
Sbjct: 29  AHSFKG-ALFGPAQALHGATFVVDVAFYRRELTVEGVVVDIGRAHDALKAVLGPLNYKNL 87

Query: 75  NDIPGL--ENPTSEVLAKWIWDQVKPVV---------PLLSAVMV--KETCTAGCIYRGE 121
           +++P     N T+EVL + ++D++               L+ + V   E+  A   +  +
Sbjct: 88  DELPDFAGRNTTTEVLCRHVFDKMAQAARAGELGAGSEALARIRVTLHESHVARAWFEAD 147


>UniRef50_Q6MLZ0 6-pyruvoyl-tetrahydropterin synthase, putative n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLZ0_BDEBA
          Length = 159

 Score = 57.8 bits (139), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 34/149 (22%), Positives = 53/149 (35%), Gaps = 41/149 (27%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH---TGWIIDFAELKAAFKP 64
           ++F F AAH L    E H   RLHGH++ V+++I    +      G+ +DF   K   K 
Sbjct: 6   QNFKFSAAHFL-IFDETH-AERLHGHNYQVKVDIKTPSEEELHSDGYFLDFNVFKKYIKA 63

Query: 65  TYERLDHHYL------------------------------NDIPGLE--NPTSE----VL 88
             ++ D   L                              N++  L   N + E    +L
Sbjct: 64  RLDQWDEMVLLPEKQKDMKFKKNGPSLEVTFRERFYAFPANEVTLLSVTNTSVEQLSRLL 123

Query: 89  AKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           A+  + + K        V V ET   G  
Sbjct: 124 AEEFFAEFKKYGVKSVRVYVAETAGQGAS 152


>UniRef50_A8AAK9 Putative uncharacterized protein n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=A8AAK9_IGNH4
          Length = 150

 Score = 57.4 bits (138), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 30/149 (20%), Positives = 54/149 (36%), Gaps = 33/149 (22%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M  T +  +  F AAH     P     G LHGH++ V++ +  E      W++D  +L+ 
Sbjct: 1   MTLTCISVEEKFPAAHY--TNPRLSPAGTLHGHNWRVKVTVCKEGVSA--WVVDAVKLRE 56

Query: 61  AFKPTYERL---------DHHY------LNDIPG-----------LENP--TSEVLAKWI 92
           A     + L         D         L ++             L  P  + E++A ++
Sbjct: 57  ALNDIIDPLRFSLLVPETDAKLWLGPKGLKELLEEALGIRVRVAVLPYPIVSGEIVAHYV 116

Query: 93  WDQVKPVV-PLLSAVMVKETCTAGCIYRG 120
             ++K  +      V V+E+      Y  
Sbjct: 117 CSRIKDEIDADCCKVEVEESPGEVATYDE 145


>UniRef50_C2FQF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Lactobacillus
           plantarum RepID=C2FQF2_LACPL
          Length = 122

 Score = 56.2 bits (135), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 21/107 (19%), Positives = 45/107 (42%), Gaps = 14/107 (13%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHH 72
            A+H +       K    H H++    EI  E+      +  F +++       + L   
Sbjct: 15  NASHAVRWATGSGK---KHTHTW----EIVCELHTVDAMVA-FYDIEKNLHQALDELSGK 66

Query: 73  YLNDIPGLE--NPTSEVLAKWIWDQ----VKPVVPLLSAVMVKETCT 113
           +LND+P  +  NPT E + ++++ +    ++     L  + V ++ T
Sbjct: 67  FLNDLPEFKTVNPTVENVTEYLFTKIDKTLRDNGAQLLRIEVSDSPT 113


>UniRef50_B7FTA7 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FTA7_PHATR
          Length = 173

 Score = 56.2 bits (135), Expect = 3e-07,   Method: Composition-based stats.
 Identities = 32/119 (26%), Positives = 51/119 (42%), Gaps = 16/119 (13%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAFKPTYER 68
           F F AAH +          RLHGH++ + + + G       G++IDF  +K   K   +R
Sbjct: 17  FKFNAAHFVAFQGYR---ERLHGHNYRIGVRLLGRRQIGADGYLIDFGCVKDVCKKVCKR 73

Query: 69  LDHHYL----NDIPGLENPTSEVLAKWI--WDQVKPVVPLLSAVMV---KETCTAGCIY 118
           ++ H+L    +D+  +   T+E  +  I   D    V P    VM+     T     IY
Sbjct: 74  INEHFLCPVHSDVLKI---TTENESVRIECADGTYFVFPAADCVMLPIFHATAEELAIY 129


>UniRef50_Q3ISX3 Homolog to 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n=1
           Tax=Natronomonas pharaonis DSM 2160 RepID=Q3ISX3_NATPD
          Length = 123

 Score = 55.8 bits (134), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 44/120 (36%), Gaps = 6/120 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T+    TF A H L           LH H+F   +   G      G+++D    + A 
Sbjct: 1   MFTVTVTETFVAQHFLTLPDPPADEATLHSHTFEAEVTFRGPELGPHGYLLDIDAAREAL 60

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVK----PVVPLLSAVMVKETCTAGCIY 118
               E      LND     NP+ E LA  ++  +     P V  L+ V + E  TA   Y
Sbjct: 61  SAAAETYRDETLNDHLD-GNPSVERLAVALFADLSSLEAPAVTELT-VAISEDDTAVASY 118


>UniRef50_A4EHB1 6-pyruvoyl tetrahydropterin synthase n=14 Tax=Bacteria
           RepID=A4EHB1_9RHOB
          Length = 131

 Score = 55.8 bits (134), Expect = 4e-07,   Method: Composition-based stats.
 Identities = 25/119 (21%), Positives = 44/119 (36%), Gaps = 13/119 (10%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
           AH LP  P       +HG +F+V      +     G ++D      A     + L +  L
Sbjct: 13  AHSLPS-PVFGPAQGMHGATFVVDAAFYTKDLDENGLVVDMGLALEALADALKPLKYANL 71

Query: 75  NDIPGLEN--PTSEVLAKWIWDQVKPVVPLLS----------AVMVKETCTAGCIYRGE 121
           +++P  +    T+E L   IW Q++                  V ++E+  A   Y  +
Sbjct: 72  DEVPAFKGKITTTEFLCHHIWQQLRETAKTTGLGDNGRVCRIKVSLEESHVARGWYEAD 130


>UniRef50_A9HRF7 Putative uncharacterized protein n=3 Tax=Acetobacteraceae
           RepID=A9HRF7_GLUDA
          Length = 181

 Score = 55.5 bits (133), Expect = 6e-07,   Method: Composition-based stats.
 Identities = 30/152 (19%), Positives = 53/152 (34%), Gaps = 34/152 (22%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT----GEVDPHTGWIIDFA 56
           M+     +   F   HRL H      C   HGH+  V + +       +D     ++ F 
Sbjct: 7   MLDLVFTRR--FSMGHRLIH-DASESCALPHGHNEFVTVRLRPTAPRPLDGAGNMVVSFQ 63

Query: 57  ELKAAFKP-TYERLDHHY-LNDIPGL-------------------ENPTSEVLAKWIWDQ 95
             K  +     ERLDH   L +   L                    +PT+E+ A  +  +
Sbjct: 64  RAKGRWHRFVDERLDHALQLAEDDPLLAWFRANEPERARRIVVTPGDPTTELTACLMMAK 123

Query: 96  VKPVVP------LLSAVMVKETCTAGCIYRGE 121
           +  ++         + + ++ET T    + GE
Sbjct: 124 LNALLDADGGVLRCAGITLQETPTNTVEFEGE 155


>UniRef50_C7XH17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Lactobacillus
           crispatus RepID=C7XH17_9LACO
          Length = 122

 Score = 54.7 bits (131), Expect = 9e-07,   Method: Composition-based stats.
 Identities = 19/106 (17%), Positives = 45/106 (42%), Gaps = 13/106 (12%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHH 72
            A+H +       +    H H++ +R         + G +I F E++       ++ ++ 
Sbjct: 15  NASHAIRWSKGIGQA---HSHTYEIRYSFH----INNGKLIRFNEIENKIAEIIKKFNNQ 67

Query: 73  YLNDIPGLE--NPTSEVLAKWIW----DQVKPVVPLLSAVMVKETC 112
           +LN++      NPT E L  +++    +++  +   L  + V E+ 
Sbjct: 68  FLNEVEPFTKVNPTLENLTDYLFNRFGEELNKLNCSLDEISVSESP 113


>UniRef50_C5SCP3 Putative uncharacterized protein n=1 Tax=Allochromatium vinosum
          DSM 180 RepID=C5SCP3_CHRVI
          Length = 174

 Score = 54.7 bits (131), Expect = 9e-07,   Method: Composition-based stats.
 Identities = 26/82 (31%), Positives = 35/82 (42%), Gaps = 7/82 (8%)

Query: 3  STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
             + KD+  F A H         +   LHGH+F VR  +T +V    G   D+  LK A
Sbjct: 14 RIEISKDYLNFSAGHF-TLFSATER-ENLHGHNFRVRCAVTAQVG-EGGLTFDYVILKRA 70

Query: 62 FKPTYERLDHHYLNDIPGLENP 83
           K   + LD   L     LE+P
Sbjct: 71 LKELCDALDERML---LPLESP 89


>UniRef50_A7VEN5 Putative uncharacterized protein n=1 Tax=Clostridium sp. L2-50
           RepID=A7VEN5_9CLOT
          Length = 146

 Score = 54.3 bits (130), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 25/98 (25%), Positives = 47/98 (47%), Gaps = 10/98 (10%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
            + F A+H      +G+K  + H H+F + L I      ++G  +DF  L    +    R
Sbjct: 8   QYHFNASHSF----DGNK-EQAHSHTFTMILYIR----NYSGRDMDFKRLDRMIEIFLGR 58

Query: 69  LDHHYLNDIPGLE-NPTSEVLAKWIWDQVKPVVPLLSA 105
            +  YLN++P    N + E +  + ++Q+K  +  L+A
Sbjct: 59  YEGMYLNELPCFAGNASIEAIGDYFYEQLKIKLSELNA 96


>UniRef50_Q8UVX7 Pyruvoyl-tetrahydropterine synthase (Fragment) n=8 Tax=Euteleostomi
           RepID=Q8UVX7_CHICK
          Length = 53

 Score = 52.8 bits (126), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 16/53 (30%), Positives = 27/53 (50%), Gaps = 5/53 (9%)

Query: 72  HYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMVKETCTAGCIYR 119
             L+ D+P       T+E +A +IW+ +K ++P   L  V V ET     +Y+
Sbjct: 1   KNLDKDVPYFAEVVSTTENVAVFIWENLKRLLPAGMLYKVKVYETDQNIVVYK 53


>UniRef50_C7JGU4 Putative uncharacterized protein n=8 Tax=Acetobacter pasteurianus
           RepID=C7JGU4_ACEP3
          Length = 182

 Score = 52.4 bits (125), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 27/151 (17%), Positives = 50/151 (33%), Gaps = 34/151 (22%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT----GEVDPHTGWIIDFA 56
           M      +   F   HRL H      C   HGH+  V + +       +D      + F 
Sbjct: 1   MPDLVFTRR--FSMGHRLIH-GASESCALPHGHNEFVTVRLKPTSFAPLDGKGNMPVSFQ 57

Query: 57  ELKAAFKPTYER-LDHHY-LNDIPGL-------------------ENPTSEVLAKWIWDQ 95
           + K+ +    +  LDH   L +   L                    +PT+E++   +  +
Sbjct: 58  KAKSTWHRFVDEKLDHALQLAEDDPLLAWFQANEPARAARIVITPGDPTTELMVCLLMAK 117

Query: 96  VKPVVPL------LSAVMVKETCTAGCIYRG 120
           +   +         S + ++ET T    + G
Sbjct: 118 INAFLAAEGGVLQCSELSIQETPTNTVSFSG 148


>UniRef50_Q6MLN9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLN9_BDEBA
          Length = 129

 Score = 51.2 bits (122), Expect = 9e-06,   Method: Composition-based stats.
 Identities = 28/123 (22%), Positives = 46/123 (37%), Gaps = 18/123 (14%)

Query: 12  FEAAHRL--PHVPEG------HKC--GRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAH    P   E        +C     HGH++M+     G    +  W       ++ 
Sbjct: 9   FSAAHFYAQPQWDEHKNRETFGRCYTQYGHGHNYMLE---AGFHCQNDSWKQQQQHYQSV 65

Query: 62  FKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMVKETCTAGC 116
                  LDH +LN  IP  +   PT+E +  +  +++K  V    +S + + E      
Sbjct: 66  LNNLTAVLDHEHLNFVIPEFKTNIPTTENICLYFLEKLKSQVKSEEISYLRLYEMDNIWT 125

Query: 117 IYR 119
             R
Sbjct: 126 EIR 128


>UniRef50_Q97FZ8 6-pyruvoyl-tetrahydropterin synthase related protein n=2
           Tax=Clostridium acetobutylicum RepID=Q97FZ8_CLOAB
          Length = 159

 Score = 50.8 bits (121), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 21/89 (23%), Positives = 43/89 (48%), Gaps = 10/89 (11%)

Query: 31  HGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEVL 88
           H H++ + +     +  HTG++I F +++   +   ++    Y+N I      NPT E +
Sbjct: 28  HPHTWEITIY---TIKFHTGFVI-FNDVERYVEKYMKKYQDSYINRIEPFITLNPTLENM 83

Query: 89  AKWIWDQVKPVVPL----LSAVMVKETCT 113
            K+  D +K ++      L ++ + ET T
Sbjct: 84  CKFFKDNMKALLAEKGWILLSIEISETPT 112


>UniRef50_A6DNS1 Putative uncharacterized protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DNS1_9BACT
          Length = 144

 Score = 50.5 bits (120), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 29/130 (22%), Positives = 44/130 (33%), Gaps = 28/130 (21%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
           AHR     +   C  +HG+   +      +      W++DF  LK       ++ DH  L
Sbjct: 14  AHR--QWRDDGDCQLVHGYDRSIHFTFESDGLDDKCWVMDFGGLKHIKAWLEDKFDHTLL 71

Query: 75  -NDIPG------------------LENPTSEVLAKWIWDQVKPVVP-------LLSAVMV 108
            N+                     L N   E  AK+I+D V P V         + +V  
Sbjct: 72  INEDDPEMAFFEEMDRKGLCRLRVLPNIGMEGSAKYIFDYVDPWVQEQTDGRVRVFSVEC 131

Query: 109 KETCTAGCIY 118
           +E      IY
Sbjct: 132 RENEKNSAIY 141


>UniRef50_B4RFN3 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Alphaproteobacteria
           RepID=B4RFN3_PHEZH
          Length = 170

 Score = 50.5 bits (120), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 28/130 (21%), Positives = 44/130 (33%), Gaps = 28/130 (21%)

Query: 18  LPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE--LKAAFKPTYERLDHHYL- 74
           L        C  LHG+S   R     E     GW++DF         +  +   DH  L 
Sbjct: 19  LRQWAADSHCALLHGYSLGFRFTFAAEQLDRRGWVVDFGSGGFGKIREWLHGTFDHALLV 78

Query: 75  -NDIPG-----------------LENPTSEVLAKWIWDQVKPVVPL-------LSAVMVK 109
             D PG                 +   + E LA+++++  +P+V         ++ V   
Sbjct: 79  AEDDPGRPELARLADLGLARVQVVPGTSCEALARFVFEAAQPMVAAATQGRCWIAEVECF 138

Query: 110 ETCTAGCIYR 119
           E      IYR
Sbjct: 139 EHGANSAIYR 148


>UniRef50_C5KJI5 Putative uncharacterized protein (Fragment) n=2 Tax=Perkinsus
          marinus ATCC 50983 RepID=C5KJI5_9ALVE
          Length = 138

 Score = 50.1 bits (119), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 18/49 (36%), Positives = 27/49 (55%), Gaps = 2/49 (4%)

Query: 28 GRLHGHSFMVRLEITGEVDP--HTGWIIDFAELKAAFKPTYERLDHHYL 74
           RLHGH++ V+L +T E  P    G++IDF  LK   +     L+ H +
Sbjct: 6  ERLHGHNYTVKLRLTCESWPAGDDGYVIDFGILKKLLRSVCRSLNEHMI 54


>UniRef50_UPI0001B4C1FC hypothetical protein ShygA5_47370 n=1 Tax=Streptomyces
          hygroscopicus ATCC 53653 RepID=UPI0001B4C1FC
          Length = 174

 Score = 49.7 bits (118), Expect = 3e-05,   Method: Composition-based stats.
 Identities = 22/60 (36%), Positives = 30/60 (50%), Gaps = 3/60 (5%)

Query: 16 HRLPHVPEGHKCGRLHGHSFMVRLEI-TGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
          HR      G KC  LHG+     +E   GE++P TG++IDF +LK        + DH  L
Sbjct: 38 HR--SWAHGGKCSFLHGYERSFEIEFGCGELEPKTGFVIDFGDLKEVRALLQAQFDHTTL 95


>UniRef50_A5GJQ8 6-pyruvoyl tetrahydropterin synthase n=24 Tax=Cyanobacteria
           RepID=A5GJQ8_SYNPW
          Length = 166

 Score = 48.9 bits (116), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 24/132 (18%), Positives = 42/132 (31%), Gaps = 28/132 (21%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYL 74
            HR         C  +HG+S    +          G+++DF+ L+   K   ++ DH +L
Sbjct: 20  CHR--QWQHPGHCRFVHGYSRSFTVWFAATALDACGFVVDFSSLRPLEKQLRDQFDHTFL 77

Query: 75  -N------------------DIPGLENPTSEVLAKWIWDQVKPVVPL-------LSAVMV 108
            N                  D+  +EN   E  A+ +W     ++            V  
Sbjct: 78  VNADDPLMEQWQALHAQDALDLRVMENVGMEASARLVWGWANTLLKERDGGRSCCWKVEA 137

Query: 109 KETCTAGCIYRG 120
           +E       Y  
Sbjct: 138 RENRANSACYEA 149


>UniRef50_B8KQC4 6-pyruvoyl tetrahydropterin synthase n=1 Tax=gamma
          proteobacterium NOR51-B RepID=B8KQC4_9GAMM
          Length = 171

 Score = 48.9 bits (116), Expect = 5e-05,   Method: Composition-based stats.
 Identities = 17/65 (26%), Positives = 28/65 (43%), Gaps = 3/65 (4%)

Query: 10 FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
            F AAH         +  RLHGH++ V + +   +    G+  D+   K   +   +RL
Sbjct: 24 HKFSAAHY-TIFTATER-ERLHGHNYSVSVRLEA-LMGDNGFSADYNVYKRRIQALCDRL 80

Query: 70 DHHYL 74
          D + L
Sbjct: 81 DEYML 85


>UniRef50_A8SSX5 Putative uncharacterized protein n=2 Tax=Clostridiales
           RepID=A8SSX5_9FIRM
          Length = 152

 Score = 47.4 bits (112), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 21/119 (17%), Positives = 46/119 (38%), Gaps = 14/119 (11%)

Query: 2   MSTTLFK-DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    +K  F   A H    + +    G +H H++ + + +    D      + F  L+ 
Sbjct: 1   MRFRQYKFKFYLNARH---GIYKNGVLGEVHPHTWEIVINVVKGRDET----VKFHHLEH 53

Query: 61  AFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAV----MVKETCT 113
             +    R     LN+I   +  NPT E + ++  D++  ++     +     + E+ +
Sbjct: 54  RVEELLNRYQDKTLNEIAPFDMINPTLENMCEYFKDELTEILNRNGWIFLMMEMSESPS 112


>UniRef50_A6GII1 Putative uncharacterized protein n=1 Tax=Plesiocystis pacifica
          SIR-1 RepID=A6GII1_9DELT
          Length = 166

 Score = 47.4 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 28/93 (30%), Positives = 39/93 (41%), Gaps = 8/93 (8%)

Query: 4  TTLFKD-FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
            LFK+   F A H         +   LHGH+F V   +TG V    G + D+   K   
Sbjct: 8  IELFKEDMKFSAGHF-TIFSATER-ENLHGHNFTVSAALTGRVGRE-GLMADYGAFKREL 64

Query: 63 KPTYERLDHHYL--NDIPGL--ENPTSEVLAKW 91
          K   +  +  ++  N  P L  E   SEVLA +
Sbjct: 65 KAMCDAWNETFMLPNCSPHLQVERTDSEVLAHY 97


>UniRef50_D0XQU8 Putative uncharacterized protein n=1 Tax=Brevundimonas
           subvibrioides ATCC 15264 RepID=D0XQU8_9CAUL
          Length = 164

 Score = 47.4 bits (112), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 25/130 (19%), Positives = 46/130 (35%), Gaps = 31/130 (23%)

Query: 15  AHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG---WIIDFAELKAAFKPTYE-RLD 70
           AHRL     G +C   HGH+  V + +  +     G   ++  F  LK  +    +  +D
Sbjct: 2   AHRL-LADAGSRCAVPHGHNEFVTVTLATDAAIDFGGSNYVASFETLKKRWHGFIDGAVD 60

Query: 71  HHY-------------------LNDIPGLE-NPTSEVLAKWIWDQVKPVVP------LLS 104
           H +                   L  +   E +PT+E  A  +  ++   +          
Sbjct: 61  HAFQVGSADPLLDWFRTHEPHRLGQLMVFEGDPTTEAFAIALRRKLDAFLADDGSPYRCV 120

Query: 105 AVMVKETCTA 114
            + ++ET T 
Sbjct: 121 ELALEETPTN 130


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_A6EFM8 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   168   5e-41
UniRef50_P65871 6-carboxy-5,6,7,8-tetrahydropterin synthase n=10...   168   5e-41
UniRef50_B2IGN7 Queuosine biosynthesis protein QueD n=4 Tax=Rhiz...   163   1e-39
UniRef50_A0PNB2 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   156   2e-37
UniRef50_C9RBW1 Putative uncharacterized protein n=1 Tax=Ammonif...   151   6e-36
UniRef50_B3DVJ6 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bac...   151   6e-36
UniRef50_Q8K9D8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=21...   151   1e-35
UniRef50_Q6MLY9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdel...   148   4e-35
UniRef50_Q3ADI6 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   145   4e-34
UniRef50_C9KKI2 Queuosine biosynthesis protein QueD n=2 Tax=Veil...   143   1e-33
UniRef50_C9LTT9 Queuosine biosynthesis protein QueD n=3 Tax=Bact...   143   2e-33
UniRef50_Q1IHK8 Putative uncharacterized protein n=3 Tax=Acidoba...   142   3e-33
UniRef50_D0B3L9 6-pyruvoyl tetrahydrobiopterin synthase n=47 Tax...   142   3e-33
UniRef50_C6QGG4 Queuosine biosynthesis protein QueD n=1 Tax=Hyph...   142   4e-33
UniRef50_Q1NNH1 Putative uncharacterized protein n=2 Tax=delta p...   141   6e-33
UniRef50_UPI0001C165E4 Dihydropteroate synthase n=1 Tax=Raphidio...   141   7e-33
UniRef50_B6CWI6 ToyB n=5 Tax=Bacteria RepID=B6CWI6_STRRM              141   8e-33
UniRef50_Q2LVK6 Queuosine biosynthesis protein n=1 Tax=Syntrophu...   141   1e-32
UniRef50_Q2K3W9 6-pyruvoyl tetrahydropterin synthase protein n=1...   140   2e-32
UniRef50_Q3ZW85 6-pyruvoyl tetrahydrobiopterin synthase n=5 Tax=...   140   2e-32
UniRef50_A4XG23 Putative uncharacterized protein n=4 Tax=Bacteri...   139   2e-32
UniRef50_Q2IJB0 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Ana...   139   3e-32
UniRef50_B9ZMJ4 Queuosine biosynthesis protein QueD n=1 Tax=Thio...   138   5e-32
UniRef50_B0TFF5 6-pyruvoyl-tetrahydropterin synthase, putative n...   138   5e-32
UniRef50_Q2IKV5 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Ana...   138   6e-32
UniRef50_Q0RM63 6-pyruvoyl tetrahydrobiopterin synthase n=11 Tax...   137   9e-32
UniRef50_A5D2E2 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Pep...   137   1e-31
UniRef50_B5YJJ7 6-pyruvoyl-tetrahydropterin synthase n=4 Tax=Bac...   137   1e-31
UniRef50_C4V0R8 Possible 6-pyruvoyltetrahydropterin synthase n=1...   134   6e-31
UniRef50_C8R1L5 Putative uncharacterized protein n=1 Tax=Desulfu...   134   6e-31
UniRef50_Q31FT9 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...   134   9e-31
UniRef50_C5SC00 Putative uncharacterized protein n=1 Tax=Allochr...   134   1e-30
UniRef50_C8VWH9 Putative uncharacterized protein n=1 Tax=Desulfo...   134   1e-30
UniRef50_C1SPF1 PreQ(0) biosynthesis protein QueD n=1 Tax=Denitr...   133   1e-30
UniRef50_B7K1S3 Queuosine biosynthesis protein QueD n=6 Tax=Cyan...   133   2e-30
UniRef50_B0VJG6 6-pyruvoyl tetrahydrobiopterin synthase family p...   133   2e-30
UniRef50_B5YCT3 6-pyruvoyl-tetrahydropterin synthase n=24 Tax=Ba...   132   3e-30
UniRef50_B8FMW4 Queuosine biosynthesis protein QueD n=3 Tax=Prot...   130   9e-30
UniRef50_C6QCT4 Putative uncharacterized protein n=1 Tax=Hyphomi...   130   9e-30
UniRef50_Q55798 6-carboxy-5,6,7,8-tetrahydropterin synthase n=7 ...   130   1e-29
UniRef50_Q03393 6-pyruvoyl tetrahydrobiopterin synthase n=19 Tax...   130   1e-29
UniRef50_B1ZTR4 Putative uncharacterized protein n=3 Tax=Bacteri...   130   1e-29
UniRef50_A6LBJ5 6-pyruvoyl-tetrahydropterin synthase n=43 Tax=Ba...   130   2e-29
UniRef50_A1HNF1 Putative uncharacterized protein n=1 Tax=Thermos...   129   2e-29
UniRef50_B9K796 Queuosine biosynthesis protein QueD n=2 Tax=Bact...   129   2e-29
UniRef50_Q3A420 6-pyruvoyl-tetrahydropterin synthase n=7 Tax=Bac...   129   2e-29
UniRef50_A8L9C2 Putative uncharacterized protein n=1 Tax=Frankia...   128   5e-29
UniRef50_Q90W95 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...   128   6e-29
UniRef50_C1A6G1 6-pyruvoyl tetrahydropterin synthase family prot...   128   6e-29
UniRef50_C0QLV0 PtpS n=8 Tax=cellular organisms RepID=C0QLV0_DESAH    128   7e-29
UniRef50_B8J0W0 Queuosine biosynthesis protein QueD n=8 Tax=Desu...   127   1e-28
UniRef50_B8DNN3 Putative uncharacterized protein n=3 Tax=Desulfo...   126   2e-28
UniRef50_B5Y6S0 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Bac...   126   2e-28
UniRef50_B1GYR9 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   126   2e-28
UniRef50_Q6ARY1 Related to 6-pyruvoyl tetrahydropterin synthase ...   126   2e-28
UniRef50_Q0BPQ0 Queuosine biosynthesis protein queD n=2 Tax=Prot...   125   3e-28
UniRef50_C0GP47 Queuosine biosynthesis protein QueD n=1 Tax=Desu...   125   3e-28
UniRef50_B9EM09 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=...   125   4e-28
UniRef50_B4RHW0 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...   125   4e-28
UniRef50_D1B660 Putative uncharacterized protein n=1 Tax=Therman...   125   4e-28
UniRef50_D2L9S0 Putative uncharacterized protein n=1 Tax=Desulfo...   125   5e-28
UniRef50_P48611 6-pyruvoyl tetrahydrobiopterin synthase n=16 Tax...   125   5e-28
UniRef50_D1NB55 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Vic...   125   6e-28
UniRef50_Q30ZA2 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   124   6e-28
UniRef50_A2BZT2 6-pyruvoyl tetrahydropterin synthase n=48 Tax=ce...   123   1e-27
UniRef50_C1TQH0 PreQ(0) biosynthesis protein QueD n=2 Tax=Bacter...   123   1e-27
UniRef50_C1DVU3 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=...   123   2e-27
UniRef50_A9AWJ6 Putative uncharacterized protein n=1 Tax=Herpeto...   122   2e-27
UniRef50_C7QN33 6-pyruvoyltetrahydropterin synthase n=3 Tax=Cyan...   122   2e-27
UniRef50_A7HXX3 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Par...   121   5e-27
UniRef50_Q3SPB8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Alp...   121   5e-27
UniRef50_C1ZE85 PreQ(0) biosynthesis protein QueD n=2 Tax=Planct...   121   6e-27
UniRef50_A9M1Z1 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   121   6e-27
UniRef50_A0M3Y1 Conserved tetrahydrobiopterin biosynthesis-like ...   121   7e-27
UniRef50_D1CA69 Putative uncharacterized protein n=1 Tax=Sphaero...   120   9e-27
UniRef50_B0SX52 Queuosine biosynthesis protein QueD n=1 Tax=Caul...   120   1e-26
UniRef50_C7HJ58 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Clo...   119   2e-26
UniRef50_B5W8I5 Putative uncharacterized protein n=3 Tax=Cyanoba...   119   2e-26
UniRef50_Q1ZXI0 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   119   2e-26
UniRef50_C6VZC4 Putative uncharacterized protein n=3 Tax=Sphingo...   119   3e-26
UniRef50_UPI0001C378A0 6-pyruvoyl tetrahydrobiopterin synthase n...   119   3e-26
UniRef50_O31676 6-carboxy-5,6,7,8-tetrahydropterin synthase n=85...   119   3e-26
UniRef50_D0Y1P4 6-pyruvoyl tetrahydropterin synthase n=3 Tax=cel...   119   4e-26
UniRef50_Q3B4V1 6-pyruvoyltetrahydropterin synthase n=11 Tax=Chl...   118   4e-26
UniRef50_Q46G73 6-pyruvoyltetrahydropterin synthase n=7 Tax=Eury...   118   5e-26
UniRef50_D0J5V8 6-pyruvoyl tetrahydropterin synthase and n=7 Tax...   118   6e-26
UniRef50_Q63E30 6-pyruvoyl tetrahydrobiopterin synthase n=100 Ta...   118   6e-26
UniRef50_D2R401 Putative uncharacterized protein n=1 Tax=Pirellu...   118   7e-26
UniRef50_Q3J9J8 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Chr...   117   8e-26
UniRef50_O29809 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...   117   9e-26
UniRef50_Q8Z0L1 Alr0080 protein n=5 Tax=Cyanobacteria RepID=Q8Z0...   117   1e-25
UniRef50_A0Q1F5 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   117   1e-25
UniRef50_Q6B324 6-pyruvoyl tetrahydropterin synthase (Fragment) ...   117   1e-25
UniRef50_A8G2B1 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Cya...   116   3e-25
UniRef50_P44123 6-carboxy-5,6,7,8-tetrahydropterin synthase n=31...   116   3e-25
UniRef50_C3KVW1 Queuosine biosynthesis protein QueD n=22 Tax=Bac...   115   3e-25
UniRef50_A0B6A5 Putative uncharacterized protein n=1 Tax=Methano...   115   3e-25
UniRef50_O66626 6-carboxy-5,6,7,8-tetrahydropterin synthase n=8 ...   115   3e-25
UniRef50_B2KC64 Putative uncharacterized protein n=1 Tax=Elusimi...   115   3e-25
UniRef50_A2SD50 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   115   3e-25
UniRef50_Q5KZY1 6-pyruvoyltetrahydropterin synthase(PTP synthase...   115   4e-25
UniRef50_O02058 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   115   5e-25
UniRef50_D2QJ42 Putative uncharacterized protein n=1 Tax=Spiroso...   115   5e-25
UniRef50_UPI0001C1695B hypothetical protein CRD_00116 n=2 Tax=No...   115   6e-25
UniRef50_Q7NSB8 Probable 6-pyruvoyltetrahydrobiopterin synthase ...   115   6e-25
UniRef50_B5JVD7 Probable 6-pyruvoyltetrahydrobiopterin synthase ...   115   6e-25
UniRef50_B9Z1F8 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Nei...   114   8e-25
UniRef50_C0N3T5 6-pyruvoyl tetrahydropterin synthase superfamily...   114   9e-25
UniRef50_A3UD70 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   114   1e-24
UniRef50_A6LWG4 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   114   1e-24
UniRef50_Q1IPI9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Aci...   113   2e-24
UniRef50_A3EQ19 Probable 6-pyruvoyl tetrahydrobiopterin synthase...   113   2e-24
UniRef50_C4XPJ5 6-pyruvoyl tetrahydropterin synthase family prot...   112   3e-24
UniRef50_C2D910 Possible 6-pyruvoyltetrahydropterin synthase n=1...   112   3e-24
UniRef50_C1CXM4 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   112   3e-24
UniRef50_A1WW30 Putative uncharacterized protein n=1 Tax=Halorho...   112   4e-24
UniRef50_A1SFN0 Putative uncharacterized protein n=1 Tax=Nocardi...   110   1e-23
UniRef50_C5A6K8 6-pyruvoyl tetrahydrobiopterin synthase (PtpS) n...   110   1e-23
UniRef50_B8G7W6 Putative 6-pyruvoyl tetrahydropterin synthase n=...   110   1e-23
UniRef50_B4D1V3 6-pyruvoyl-tetrahydropterin synthase-like protei...   110   2e-23
UniRef50_A3ZTI8 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...   110   2e-23
UniRef50_D1JB18 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   109   3e-23
UniRef50_C5RIU8 Putative 6-pyruvoyl tetrahydropterin synthase n=...   109   3e-23
UniRef50_Q604L2 Putative 6-pyruvoyl tetrahydropterin synthase n=...   108   7e-23
UniRef50_Q2PY17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bac...   108   7e-23
UniRef50_Q04S36 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Lep...   107   8e-23
UniRef50_Q1NNT9 Putative uncharacterized protein n=2 Tax=delta p...   107   1e-22
UniRef50_Q1IPJ0 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Can...   107   1e-22
UniRef50_D2ML00 Putative uncharacterized protein (Fragment) n=1 ...   107   1e-22
UniRef50_A8Y1U6 C. briggsae CBR-PTPS-1 protein n=2 Tax=Caenorhab...   106   3e-22
UniRef50_Q7UGM2 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...   105   3e-22
UniRef50_A7BS03 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Beg...   105   4e-22
UniRef50_D0MDN2 Putative uncharacterized protein n=1 Tax=Rhodoth...   104   7e-22
UniRef50_A0L5B3 Putative uncharacterized protein n=1 Tax=Magneto...   104   1e-21
UniRef50_C1AB96 6-pyruvoyl tetrahydropterin synthase family prot...   104   1e-21
UniRef50_Q0AAF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Pro...   104   1e-21
UniRef50_Q675S7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...   104   1e-21
UniRef50_A4CIF9 6-pyruvoyl tetrahydropterin synthase n=19 Tax=Ba...   103   2e-21
UniRef50_Q1RHI6 6-carboxy-5,6,7,8-tetrahydropterin synthase n=4 ...   103   2e-21
UniRef50_UPI0001C418E1 queuosine biosynthesis protein QueD n=1 T...   103   2e-21
UniRef50_Q3ATI1 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   103   2e-21
UniRef50_B2UBF2 Queuosine biosynthesis protein QueD n=85 Tax=cel...   102   3e-21
UniRef50_Q0KAE6 6-Pyruvoyl tetrahydrobiopterin synthase protein ...   102   3e-21
UniRef50_B3T9P1 Putative 6-pyruvoyl tetrahydropterin synthase n=...   102   3e-21
UniRef50_B3QUQ1 Putative uncharacterized protein n=1 Tax=Chloroh...   102   4e-21
UniRef50_Q3B2Y4 6-pyruvoyl tetrahydrobiopterin synthase, putativ...   102   4e-21
UniRef50_Q92J44 6-carboxy-5,6,7,8-tetrahydropterin synthase n=11...   102   4e-21
UniRef50_A3VUJ4 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...   101   6e-21
UniRef50_C7MN71 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Cor...   101   7e-21
UniRef50_Q1IAJ5 Putative 6-pyruvoyl-tetrahydropterin synthase-li...   101   8e-21
UniRef50_C7IE00 Putative uncharacterized protein n=1 Tax=Clostri...   100   2e-20
UniRef50_A6GQ16 Putative 6-pyruvoyl tetrahydrobiopterin synthase...   100   2e-20
UniRef50_D1R7R7 Putative uncharacterized protein n=2 Tax=Parachl...   100   2e-20
UniRef50_A1ZSU4 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=...    99   4e-20
UniRef50_A9GTQ5 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sora...    99   5e-20
UniRef50_A2STX2 6-pyruvoyl-tetrahydropterin synthase-like protei...    98   7e-20
UniRef50_B2UPS6 6-pyruvoyl-tetrahydropterin synthase-like protei...    98   8e-20
UniRef50_C6MFP0 Queuosine biosynthesis protein QueD n=1 Tax=Nitr...    98   9e-20
UniRef50_A0JSM2 Putative uncharacterized protein n=7 Tax=Bacteri...    97   1e-19
UniRef50_UPI00016C4ECA 6-pyruvoyl tetrahydrobiopterin synthase n...    97   2e-19
UniRef50_C1VD01 PreQ(0) biosynthesis protein QueD n=1 Tax=Haloge...    96   3e-19
UniRef50_B8HQA0 Putative uncharacterized protein n=1 Tax=Cyanoth...    96   4e-19
UniRef50_A1VXP3 6-pyruvoyl tetrahydrobiopterin synthase, homolog...    96   5e-19
UniRef50_Q2RTB4 Putative uncharacterized protein n=1 Tax=Rhodosp...    94   1e-18
UniRef50_UPI0001B56D65 putative 6-pyruvoyl tetrahydropterin synt...    93   3e-18
UniRef50_C9ZBP0 Putative uncharacterized protein n=2 Tax=Strepto...    92   4e-18
UniRef50_C0BIT7 6-pyruvoyl tetrahydropterin synthase n=6 Tax=Bac...    92   5e-18
UniRef50_UPI000038E306 6-pyruvoyltetrahydrobiopterin synthase n=...    92   6e-18
UniRef50_B2RKC2 Putative uncharacterized protein n=3 Tax=Bacteri...    91   9e-18
UniRef50_C3JCW3 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=...    91   1e-17
UniRef50_B6IVH4 6-pyruvoyl tetrahydropterin synthase, putative n...    91   1e-17
UniRef50_Q028J7 Putative uncharacterized protein n=1 Tax=Candida...    91   1e-17
UniRef50_A9KBA1 Queuosine biosynthesis protein n=7 Tax=Gammaprot...    90   2e-17
UniRef50_A7IHR5 Putative uncharacterized protein n=4 Tax=Bacteri...    90   2e-17
UniRef50_O59602 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    90   2e-17
UniRef50_B8C0F3 Predicted protein n=1 Tax=Thalassiosira pseudona...    90   2e-17
UniRef50_B2HZD9 6-pyruvoyl-tetrahydropterin synthase n=31 Tax=Pr...    90   3e-17
UniRef50_UPI0001B56179 putative 6-pyruvoyl tetrahydropterin synt...    89   4e-17
UniRef50_B6R1Q6 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Pse...    89   4e-17
UniRef50_Q8TX57 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Met...    89   4e-17
UniRef50_B0R4P7 6-pyruvoyltetrahydropterin synthase n=4 Tax=Halo...    89   6e-17
UniRef50_B5JFE1 Putative uncharacterized protein n=1 Tax=Verruco...    88   7e-17
UniRef50_Q18HJ5 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n...    88   8e-17
UniRef50_A9B2M7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=...    88   9e-17
UniRef50_O27296 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    88   9e-17
UniRef50_Q979P1 Putative uncharacterized protein TVG1150731 n=2 ...    88   1e-16
UniRef50_A4TYV7 Putative uncharacterized protein n=1 Tax=Magneto...    87   1e-16
UniRef50_D1X5B9 6-pyruvoyl-tetrahydropterin synthase-like protei...    87   1e-16
UniRef50_Q9HHN6 Vng6306c n=3 Tax=Halobacteriaceae RepID=Q9HHN6_H...    86   3e-16
UniRef50_B7FYC8 Predicted protein n=1 Tax=Phaeodactylum tricornu...    86   3e-16
UniRef50_Q4JA84 Conserved Archaeal protein n=12 Tax=Sulfolobacea...    86   3e-16
UniRef50_B2KCS0 Putative uncharacterized protein n=1 Tax=Elusimi...    86   4e-16
UniRef50_A2BJ89 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Hyp...    86   5e-16
UniRef50_B6KR79 Putative uncharacterized protein n=3 Tax=Toxopla...    84   9e-16
UniRef50_Q1LPD9 6-pyruvoyl-tetrahydropterin synthase-like protei...    84   2e-15
UniRef50_C1YMA8 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Noc...    83   3e-15
UniRef50_D2RQ20 6-pyruvoyl-tetrahydropterin synthase-like protei...    82   4e-15
UniRef50_D0MWX1 Putative uncharacterized protein n=2 Tax=Phytoph...    82   5e-15
UniRef50_A6DNS1 Putative uncharacterized protein n=1 Tax=Lentisp...    82   7e-15
UniRef50_A4FWS8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Met...    82   7e-15
UniRef50_Q1D8H8 Putative uncharacterized protein n=1 Tax=Myxococ...    81   8e-15
UniRef50_D0LLG1 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Hal...    80   2e-14
UniRef50_Q0AV03 6-pyruvoyl-tetrahydropterin synthase related dom...    79   4e-14
UniRef50_A9LH53 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=unc...    79   4e-14
UniRef50_Q4JIS7 Putative 6-pyruvoyl tetrahydropterin synthase n=...    79   4e-14
UniRef50_D2EHH0 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Ped...    79   5e-14
UniRef50_A4EHB1 6-pyruvoyl tetrahydropterin synthase n=14 Tax=Ba...    79   5e-14
UniRef50_Q3ISX3 Homolog to 6-pyruvoyltetrahydropterin synthase (...    79   6e-14
UniRef50_Q6AKY1 Related to 6-pyruvoyl-tetrahydropterin synthase ...    78   7e-14
UniRef50_Q9ZKR8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=14...    77   1e-13
UniRef50_A5GJQ8 6-pyruvoyl tetrahydropterin synthase n=24 Tax=Cy...    77   1e-13
UniRef50_B9LV86 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Hal...    77   2e-13
UniRef50_D2R465 6-pyruvoyl tetrahydrobiopterin synthase; K01737 ...    77   2e-13
UniRef50_Q4LA59 Similar to 6-pyruvoyl tetrahydropterin synthase ...    76   3e-13
UniRef50_A8AAK9 Putative uncharacterized protein n=1 Tax=Ignicoc...    76   4e-13
UniRef50_C1ZCI0 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Pla...    76   5e-13
UniRef50_Q6L053 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=P...    75   6e-13
UniRef50_Q7UMI8 Putative uncharacterized protein n=2 Tax=Plancto...    75   6e-13
UniRef50_A9HRF7 Putative uncharacterized protein n=3 Tax=Acetoba...    75   7e-13
UniRef50_A9G7Q3 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sora...    75   9e-13
UniRef50_UPI0001AF6FD6 hypothetical protein MkanA1_23688 n=1 Tax...    74   1e-12
UniRef50_UPI0001AF6FD4 hypothetical protein MkanA1_23678 n=2 Tax...    74   2e-12
UniRef50_C5SEY8 Putative uncharacterized protein n=1 Tax=Asticca...    73   2e-12
UniRef50_D1W1T6 Conserved domain protein (Fragment) n=4 Tax=Bact...    73   2e-12
UniRef50_B5I9Q5 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=...    72   5e-12
UniRef50_Q1WTR4 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Lac...    72   6e-12
UniRef50_C7XH17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Lac...    72   7e-12
UniRef50_C7JGU4 Putative uncharacterized protein n=8 Tax=Acetoba...    71   1e-11
UniRef50_Q6MLN9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdel...    71   1e-11
UniRef50_Q19Z82 Gp4 n=2 Tax=unclassified Siphoviridae RepID=Q19Z...    70   2e-11
UniRef50_Q58668 Putative 6-carboxy-5,6,7,8-tetrahydropterin synt...    70   2e-11
UniRef50_P80081 6-pyruvoyl tetrahydrobiopterin synthase (Fragmen...    70   2e-11
UniRef50_Q97FZ8 6-pyruvoyl-tetrahydropterin synthase related pro...    69   3e-11
UniRef50_B4RFN3 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=...    69   4e-11
UniRef50_C2FQF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Lac...    69   4e-11
UniRef50_D1B474 Putative uncharacterized protein n=3 Tax=Campylo...    69   5e-11
UniRef50_C6KTB6 6-pyruvoyltetrahydropterin synthase n=6 Tax=Plas...    68   7e-11
UniRef50_A0RWH6 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Arc...    68   9e-11
UniRef50_Q6MLZ0 6-pyruvoyl-tetrahydropterin synthase, putative n...    68   1e-10
UniRef50_A8SSX5 Putative uncharacterized protein n=2 Tax=Clostri...    66   3e-10
UniRef50_B7FTA7 Predicted protein n=1 Tax=Phaeodactylum tricornu...    66   4e-10
UniRef50_A9VWK7 Putative uncharacterized protein n=3 Tax=Methylo...    65   8e-10
UniRef50_B9Z9U9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Hal...    65   9e-10
UniRef50_A7VEN5 Putative uncharacterized protein n=1 Tax=Clostri...    64   2e-09
UniRef50_Q4A0G7 Putative 6-pyruvoyl tetrahydrobiopterin synthase...    64   2e-09
UniRef50_Q97G44 6-pyruvoyl-tetrahydropterin synthase related pro...    64   2e-09
UniRef50_Q97FZ3 6-pyruvoyl-tetrahydropterin synthase related dom...    63   2e-09
UniRef50_UPI0001B4C1FC hypothetical protein ShygA5_47370 n=1 Tax...    61   9e-09
UniRef50_C5SCP3 Putative uncharacterized protein n=1 Tax=Allochr...    60   3e-08
UniRef50_D0XQU8 Putative uncharacterized protein n=1 Tax=Brevund...    60   3e-08

Sequences not found previously or not previously below threshold:

>UniRef50_A6EFM8 6-pyruvoyl tetrahydrobiopterin synthase, putative n=2 Tax=Bacteria
           RepID=A6EFM8_9SPHI
          Length = 117

 Score =  168 bits (427), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 58/117 (49%), Positives = 82/117 (70%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K F+F++AH LP VP  HKCGR+HGH++ + + ++G  DPH+GW+ DF +LK   +
Sbjct: 1   MIIYKKFSFDSAHYLPLVPASHKCGRMHGHTYQLTVYLSGTPDPHSGWVADFGDLKRGIQ 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           P  + LDH  LNDIPGLENPTSE L+ W+W ++KPV P L+ + + ET   G IY G
Sbjct: 61  PFVDLLDHRLLNDIPGLENPTSENLSVWLWQKIKPVFPALAKIELSETPGTGVIYEG 117


>UniRef50_P65871 6-carboxy-5,6,7,8-tetrahydropterin synthase n=102
           Tax=Proteobacteria RepID=QUED_ECO57
          Length = 121

 Score =  168 bits (426), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 121/121 (100%), Positives = 121/121 (100%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA
Sbjct: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG
Sbjct: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120

Query: 121 E 121
           E
Sbjct: 121 E 121


>UniRef50_B2IGN7 Queuosine biosynthesis protein QueD n=4 Tax=Rhizobiales
           RepID=B2IGN7_BEII9
          Length = 117

 Score =  163 bits (414), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 66/117 (56%), Positives = 83/117 (70%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + + F FEAAHRLP VPEGH+C  LHGHS+ V L + G VDP TG++IDF +++A F 
Sbjct: 1   MKITQAFHFEAAHRLPKVPEGHRCANLHGHSYRVELYLEGPVDPDTGFVIDFFDIEAVFG 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           P   RLDHHYLN+I GLENPT+E++A WIWD+VKP +P L  V+V ET      Y G
Sbjct: 61  PLLHRLDHHYLNEIEGLENPTAELIAVWIWDRVKPSLPQLVKVIVYETPDCWAEYEG 117


>UniRef50_A0PNB2 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Mycobacterium
           RepID=A0PNB2_MYCUA
          Length = 160

 Score =  156 bits (394), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 72/122 (59%), Positives = 94/122 (77%), Gaps = 2/122 (1%)

Query: 1   MMST-TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
           MM T  ++ +FTFE+AHRLP+VP GHKCGRLHGHS+  R  + G VDP  GWI+DF ++K
Sbjct: 1   MMDTAEIYCEFTFESAHRLPNVPAGHKCGRLHGHSYRARTYVEGPVDPRAGWIVDFGKIK 60

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-LLSAVMVKETCTAGCIY 118
            A KP   RLDH+YLN+I GLENPTSE L+ WIW ++  ++P ++SAV V ETC++GC+Y
Sbjct: 61  DACKPVIARLDHYYLNEIDGLENPTSEQLSMWIWRELATLLPMMMSAVSVSETCSSGCMY 120

Query: 119 RG 120
           RG
Sbjct: 121 RG 122


>UniRef50_C9RBW1 Putative uncharacterized protein n=1 Tax=Ammonifex degensii KC4
           RepID=C9RBW1_AMMDK
          Length = 124

 Score =  151 bits (383), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 44/124 (35%), Positives = 64/124 (51%), Gaps = 10/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L    +F AAHRLP+ P    C RLHGH++ V + + GE     G ++DF  LK   
Sbjct: 1   MYRLTVKGSFSAAHRLPNHP--SPCSRLHGHNWEVTVTVIGEELGPDGMLLDFTVLKQIL 58

Query: 63  KPTYERLDHHYLNDIPGLE---NPTSEVLAKWIWDQVKPVVP-----LLSAVMVKETCTA 114
           +    +LDH YLN+IP       PT+E LA++I+ +V   +       L  V V E+ +A
Sbjct: 59  QEVLAKLDHQYLNEIPPFGKELPPTAENLARYIYHEVATRLAPYPAVTLQEVKVGESPSA 118

Query: 115 GCIY 118
             +Y
Sbjct: 119 WVVY 122


>UniRef50_B3DVJ6 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bacteria
           RepID=B3DVJ6_METI4
          Length = 161

 Score =  151 bits (382), Expect = 6e-36,   Method: Composition-based stats.
 Identities = 60/120 (50%), Positives = 77/120 (64%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L KDF FEAA  LP  PEGHKC R HGHSF + + + GEVDP  G + D  ++  A
Sbjct: 42  MHVILSKDFDFEAAQALPSFPEGHKCRRTHGHSFKLTVSVRGEVDPQKGVLYDHGKISEA 101

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
             P  E+LDH+YLNDI GL NPT E +A W W+++K  +P L  + ++ET    CIYRG+
Sbjct: 102 VCPLIEQLDHYYLNDIEGLSNPTIENMAGWFWNKLKDKLPGLYEITIQETARTRCIYRGD 161


>UniRef50_Q8K9D8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=210 Tax=Bacteria
           RepID=QUED_BUCAP
          Length = 120

 Score =  151 bits (381), Expect = 1e-35,   Method: Composition-based stats.
 Identities = 77/119 (64%), Positives = 101/119 (84%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M T +FKDF FEAAH LP+VP+ HKC RLHGHSF VRLE+  +++   GWIID+AE+K A
Sbjct: 1   MKTIIFKDFQFEAAHYLPYVPKMHKCRRLHGHSFFVRLELKDKINEKNGWIIDYAEIKLA 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           F+P Y++LDHH+LNDIPGLENPTSE+LAKWIW ++KP + +L+ +++KETCT+GCIY+G
Sbjct: 61  FQPIYDQLDHHFLNDIPGLENPTSEILAKWIWHRLKPKLSILNTIIIKETCTSGCIYQG 119


>UniRef50_Q6MLY9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLY9_BDEBA
          Length = 135

 Score =  148 bits (375), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 55/117 (47%), Positives = 79/117 (67%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L + F  E+A  LPH+P  H C R+HGHSF + L + G++DP  GW+ID+ +++A 
Sbjct: 16  MKFELKQHFQIESARFLPHLPASHPCSRMHGHSFKLILTLVGDLDPKIGWVIDYNDIQAL 75

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
            KP  +++DH  LN++PGLENPTSE+LAKW++D+ +P +P L  V V ET    C Y
Sbjct: 76  MKPLLDQIDHRVLNEVPGLENPTSELLAKWLYDKARPFLPTLVKVTVAETPATECSY 132


>UniRef50_Q3ADI6 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3ADI6_CARHZ
          Length = 120

 Score =  145 bits (367), Expect = 4e-34,   Method: Composition-based stats.
 Identities = 40/123 (32%), Positives = 60/123 (48%), Gaps = 8/123 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    TF+AAH L       KC  LHGH++ V  E+ G+     G +IDF  +K   
Sbjct: 1   MFKISVSTTFDAAHFLKDYD--GKCANLHGHTWRVEAEVEGQTTNDLGLLIDFGMIKDYL 58

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV-----PLLSAVMVKETCTAGCI 117
           K    RLDH  LND+  + NPT+E +A++I+ ++K  +       L +V V E+      
Sbjct: 59  KDITSRLDHKLLNDVLQV-NPTAENIARYIFKELKAKLIVYPEIKLCSVKVWESPNNAAT 117

Query: 118 YRG 120
           Y  
Sbjct: 118 YME 120


>UniRef50_C9KKI2 Queuosine biosynthesis protein QueD n=2 Tax=Veillonellaceae
           RepID=C9KKI2_9FIRM
          Length = 136

 Score =  143 bits (362), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 43/127 (33%), Positives = 65/127 (51%), Gaps = 10/127 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL  +  FEAAHR+ + P   KC RLHGH++ V   + G      G ++DF  +K A 
Sbjct: 12  MYTLKVEGAFEAAHRVVNYP--GKCDRLHGHNWKVEAVVRGTELDELGMLVDFKAIKNAL 69

Query: 63  KPTYERLDHHYLNDIPGLE---NPTSEVLAKWIWDQVKP-----VVPLLSAVMVKETCTA 114
           K   +R DH +LN++       NPT+E LA+ I++++           L A+ V ET T+
Sbjct: 70  KGVLDRFDHRFLNELEPFAAGINPTAENLARIIFEELAGNDAFVRDSELFAITVYETPTS 129

Query: 115 GCIYRGE 121
              Y  +
Sbjct: 130 SVTYTRD 136


>UniRef50_C9LTT9 Queuosine biosynthesis protein QueD n=3 Tax=Bacteria
           RepID=C9LTT9_9FIRM
          Length = 125

 Score =  143 bits (361), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 43/127 (33%), Positives = 66/127 (51%), Gaps = 10/127 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  +  FEAAHR+ + P   KC RLHGH++ V L+I+G      G +IDF   KA  
Sbjct: 1   MFEIKVEEEFEAAHRIVNYP--GKCDRLHGHNWKVELKISGSRLDELGMLIDFKAAKAML 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV------PLLSAVMVKETCTA 114
           +     LDH +LN++      NPT+E +A++I+ ++K           L+AV V E+  A
Sbjct: 59  QEVVNSLDHRFLNELEPFSEINPTAENIARYIYQELKQREIFCNDSVHLAAVCVWESPRA 118

Query: 115 GCIYRGE 121
              Y  +
Sbjct: 119 CATYTED 125


>UniRef50_Q1IHK8 Putative uncharacterized protein n=3 Tax=Acidobacteria
           RepID=Q1IHK8_ACIBL
          Length = 125

 Score =  142 bits (360), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 11/127 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  + TF A H L +     KC   HGH++ VR+ + G    H G ++DF +LK   
Sbjct: 1   MYEVTVEDTFAAGHYLRNYK--GKCENPHGHNYKVRVTLQGRELDHAGLLLDFKDLKVVM 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSA-------VMVKETCT 113
           KP  + LDH  +NDIP     NP++E +A++ +D+    +   ++       V + ET T
Sbjct: 59  KPVVDYLDHQMMNDIPPFNEVNPSAENIARYFYDECNKFLAGQTSGRVRVKDVTIWETDT 118

Query: 114 AGCIYRG 120
               Y  
Sbjct: 119 TTATYYE 125


>UniRef50_D0B3L9 6-pyruvoyl tetrahydrobiopterin synthase n=47 Tax=Bacteria
           RepID=D0B3L9_BRUME
          Length = 121

 Score =  142 bits (359), Expect = 3e-33,   Method: Composition-based stats.
 Identities = 43/117 (36%), Positives = 64/117 (54%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + K+F F A+H+L  +P  H+C RLHGH+++V +E++       G++ D+ EL A  
Sbjct: 1   MFRITKEFHFSASHQLTGLPADHQCARLHGHNYIVEVELSAPDLDTHGFVRDYHELAALK 60

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
               +  DH +LND+ G E  T+E LAK  +D      P +SAV V ET      YR
Sbjct: 61  HYIDDTFDHRHLNDVLGHEQTTAERLAKHFFDWCHARWPEISAVRVSETPKTWAEYR 117


>UniRef50_C6QGG4 Queuosine biosynthesis protein QueD n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QGG4_9RHIZ
          Length = 181

 Score =  142 bits (358), Expect = 4e-33,   Method: Composition-based stats.
 Identities = 48/114 (42%), Positives = 66/114 (57%), Gaps = 1/114 (0%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +   +TFEAAH LP V +GHKC RLHGH++ V + + G      G+++D+AEL    +
Sbjct: 67  IRITATYTFEAAHFLPKVHDGHKCRRLHGHNYRVDVSVAG-GLDERGFVLDYAELDGIVQ 125

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           P  + LDH  LNDIPGLENPTSE+LA W+  ++         + V ET      
Sbjct: 126 PVIDELDHRCLNDIPGLENPTSEILALWLRSRIAAKAGTKPMIRVWETPRYLVE 179


>UniRef50_Q1NNH1 Putative uncharacterized protein n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NNH1_9DELT
          Length = 122

 Score =  141 bits (356), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 38/124 (30%), Positives = 61/124 (49%), Gaps = 8/124 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +F +  F + H L + P    C + HGH++ V + +  +     G  +DF +LK A 
Sbjct: 1   MYDIFTESHFSSGHHLRNYP--GNCEKPHGHNWKVEVTVRADELDQLGMGLDFRDLKGAV 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
           K   + LDH  LND P  +  NP+SE +A++I+ ++K  +         V V+ET   G 
Sbjct: 59  KEVVDDLDHRDLNDHPAFQEINPSSENIARYIFVELKKRLQNDRCRPHKVTVRETDACGV 118

Query: 117 IYRG 120
            YR 
Sbjct: 119 TYRE 122


>UniRef50_UPI0001C165E4 Dihydropteroate synthase n=1 Tax=Raphidiopsis brookii D9
           RepID=UPI0001C165E4
          Length = 450

 Score =  141 bits (356), Expect = 7e-33,   Method: Composition-based stats.
 Identities = 52/121 (42%), Positives = 77/121 (63%), Gaps = 7/121 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAELK 59
             + K+F FEAAH+LP+     KC RLH HS+   + + G+   ++G     I+D+ ++ 
Sbjct: 321 WIIGKEFRFEAAHQLPNHD--GKCARLHDHSWRGVVYVAGDKLINSGVKQGMIMDYGDIS 378

Query: 60  AAFKPTYE-RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
              KP  E  LDH++LN+  GL NPTSE +AKWI++Q++P +P L AV + ETCT+ CIY
Sbjct: 379 KYIKPLLENYLDHYHLNESTGLANPTSEAIAKWIYEQLEPQIPGLVAVRIDETCTSQCIY 438

Query: 119 R 119
            
Sbjct: 439 S 439


>UniRef50_B6CWI6 ToyB n=5 Tax=Bacteria RepID=B6CWI6_STRRM
          Length = 131

 Score =  141 bits (355), Expect = 8e-33,   Method: Composition-based stats.
 Identities = 46/119 (38%), Positives = 70/119 (58%), Gaps = 2/119 (1%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG--EVDPHTGWIIDFAELKAA 61
             + K+F F A+HRL H+ EGH C R+HGH+++V LE++   +     G++ D+ EL A 
Sbjct: 13  FRISKEFHFSASHRLDHLDEGHPCSRMHGHNYVVELELSAGDDALTKAGFVRDYGELAAF 72

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            +     LDH +LND+    NP++E LA+WI ++ +   P L+AV V ET      YR 
Sbjct: 73  KQWLDAELDHRHLNDVVDGLNPSAENLARWIHERWRTGFPELTAVRVSETDKTWAEYRA 131


>UniRef50_Q2LVK6 Queuosine biosynthesis protein n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVK6_SYNAS
          Length = 159

 Score =  141 bits (355), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 39/123 (31%), Positives = 62/123 (50%), Gaps = 8/123 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +  +  F AAH L + P    C  LHGH++ V + +  E     G  IDF E+K + +
Sbjct: 38  FEISIEEQFSAAHALRNYP--GNCEHLHGHNWAVEVTVECEELNEIGIGIDFREVKQSVR 95

Query: 64  PTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCI 117
               RLDH  LN++P     NP+SE +A+ +++++   +      +S V V ET T+   
Sbjct: 96  EALHRLDHVNLNELPQFCDINPSSENIARHLYNELSRKLNTEKIRVSRVRVSETPTSKAS 155

Query: 118 YRG 120
           YR 
Sbjct: 156 YRE 158


>UniRef50_Q2K3W9 6-pyruvoyl tetrahydropterin synthase protein n=19
           Tax=Alphaproteobacteria RepID=Q2K3W9_RHIEC
          Length = 119

 Score =  140 bits (353), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 43/118 (36%), Positives = 66/118 (55%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K+F   A+H+L H+P  H+C RLHGH+++V +E++ E     G++ D+ +L   
Sbjct: 1   MMYRITKEFHLSASHQLDHLPADHQCARLHGHNYVVVVELSAENLNDDGFVRDYHDLAPL 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
            +   E LDH +LN++ G    TSE LAK  +D  +   P  S+V V ET      YR
Sbjct: 61  KRYIDESLDHRHLNEVFGHSKVTSEFLAKHFYDWCRERFPETSSVRVSETPKTWAEYR 118


>UniRef50_Q3ZW85 6-pyruvoyl tetrahydrobiopterin synthase n=5 Tax=Dehalococcoides
           RepID=Q3ZW85_DEHSC
          Length = 123

 Score =  140 bits (353), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 38/125 (30%), Positives = 56/125 (44%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     FEAAH L       KC  LHGH + V L++        G   DF+ LK   
Sbjct: 1   MYYLSVKKHFEAAHFLRGYK--GKCENLHGHRYEVALKVKTGELDECGMGADFSLLKTRL 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVK----PVVPLLSAVMVKETCTAGC 116
               +  DH  LND+   +  NP++E +AK I+D++K         L  V V E+  +  
Sbjct: 59  NEVLQSYDHTCLNDLTPFDNINPSAENIAKDIYDKLKTVINKKGVELWGVEVWESPDSSV 118

Query: 117 IYRGE 121
           +Y+ +
Sbjct: 119 LYQPD 123


>UniRef50_A4XG23 Putative uncharacterized protein n=4 Tax=Bacteria
           RepID=A4XG23_CALS8
          Length = 121

 Score =  139 bits (352), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 51/123 (41%), Positives = 68/123 (55%), Gaps = 10/123 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF- 62
             L K F F+AAH L       KC RLHGH++ + + + G+       +IDFA LK    
Sbjct: 1   MLLKKIFKFDAAHNLTKY--HGKCERLHGHTYKLVVTVKGK-LDEQDMVIDFALLKDIVQ 57

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIY 118
           K   + LDH YLNDI  +ENPT+E +AKWIW ++   +      L  V V ET  +G +Y
Sbjct: 58  KEVIDILDHAYLNDI--IENPTAENIAKWIWQRLYDKIKAQNSTLYEVEVWETEDSGAVY 115

Query: 119 RGE 121
           RGE
Sbjct: 116 RGE 118


>UniRef50_Q2IJB0 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Anaeromyxobacter
           RepID=Q2IJB0_ANADE
          Length = 129

 Score =  139 bits (350), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 45/119 (37%), Positives = 67/119 (56%), Gaps = 5/119 (4%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L  +F F AAHRLP       C R+HGH++   + + GEVDP TG I DF ++K   
Sbjct: 11  RMRLDVEFYFAAAHRLPRYE--GPCFRMHGHNYRFFVALEGEVDPATGMIADFGDVKRIV 68

Query: 63  KP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
                 R+DH  LND+  L+NPT+E +A+W+W+ ++P +  L  + + E   +   YRG
Sbjct: 69  AEHVLARVDHRTLNDV--LDNPTAENIARWMWEVLEPHLAGLCEIRLYEIPDSCVTYRG 125


>UniRef50_B9ZMJ4 Queuosine biosynthesis protein QueD n=1 Tax=Thioalkalivibrio sp.
           K90mix RepID=B9ZMJ4_9GAMM
          Length = 127

 Score =  138 bits (349), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 39/125 (31%), Positives = 61/125 (48%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL     F +AH L   P   +C  +HGH++ V  E+  E     G  +DF  +K A 
Sbjct: 4   RYTLRVLTDFASAHTLRDYP--GQCANMHGHNWKVEAEVQAETLDDAGMAVDFKVVKTAA 61

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
           +    +LDH YLND+P  +  NPT+E +A+W + Q+   +      + A+ + ET  A  
Sbjct: 62  REIAGQLDHRYLNDVPPFDTVNPTAENIAQWFFRQMSERLNRPGLRMHALTLWETDRACV 121

Query: 117 IYRGE 121
            Y  +
Sbjct: 122 RYSED 126


>UniRef50_B0TFF5 6-pyruvoyl-tetrahydropterin synthase, putative n=2
           Tax=Clostridiales RepID=B0TFF5_HELMI
          Length = 130

 Score =  138 bits (348), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 36/127 (28%), Positives = 59/127 (46%), Gaps = 10/127 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F+AAH L   P    C R+HGH++ V + + G      G +IDF E+K A 
Sbjct: 1   MYELIVQTHFDAAHYLRDYP--GDCARVHGHTWQVEVTLVGRQLDDLGMLIDFKEVKKAV 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP------LLSAVMVKETCTA 114
           K   ++LDH  +N+       NPT+E L+ + + ++   +        +  V + E+  A
Sbjct: 59  KAICDQLDHRMINEHDYFLQRNPTAENLSCYFFHELAGWLKENHPHVRVGTVRIWESPRA 118

Query: 115 GCIYRGE 121
              YR +
Sbjct: 119 SICYRAD 125


>UniRef50_Q2IKV5 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Anaeromyxobacter
           RepID=Q2IKV5_ANADE
          Length = 138

 Score =  138 bits (348), Expect = 6e-32,   Method: Composition-based stats.
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 11/129 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
               + KDF F AAH++     G KC RLHGH++ VR+          G +IDFA+L+  
Sbjct: 12  PVYEISKDFVFSAAHQIRF--HGGKCERLHGHNWRVRVHARASTLNRIGMVIDFADLQKL 69

Query: 62  FKPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLL-------SAVMVKETC 112
                 R DH  +N++     EN T+E++A++ + ++   +  L       + V V E  
Sbjct: 70  VAEVGSRFDHQNVNEVAPFDQENTTAELIARFFYREMSRRLAELEGGRVTVARVDVWENE 129

Query: 113 TAGCIYRGE 121
            +  IYR E
Sbjct: 130 GSLAIYREE 138


>UniRef50_Q0RM63 6-pyruvoyl tetrahydrobiopterin synthase n=11 Tax=Bacteria
           RepID=Q0RM63_FRAAA
          Length = 130

 Score =  137 bits (346), Expect = 9e-32,   Method: Composition-based stats.
 Identities = 45/124 (36%), Positives = 66/124 (53%), Gaps = 5/124 (4%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M +  + K F F A+HRL  +P  HKC RLHGH++ VR+++ GE     G+++D+ EL  
Sbjct: 3   MPAFEISKTFEFSASHRLSGLPADHKCARLHGHNYTVRVQLRGETLDPVGFLLDYGELSP 62

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVM----VKETCTAGC 116
                   LDH +LN      NPT+E+LA+ +   V+ +VP+   V     V ET     
Sbjct: 63  VRDWIDAALDHQHLNACLDF-NPTAELLAQHLAGTVRQLVPIPDGVRVAVGVSETPRTWA 121

Query: 117 IYRG 120
            YR 
Sbjct: 122 FYRE 125


>UniRef50_A5D2E2 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Peptococcaceae
           RepID=A5D2E2_PELTS
          Length = 129

 Score =  137 bits (346), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 35/127 (27%), Positives = 60/127 (47%), Gaps = 13/127 (10%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    +F AAH +        C R+HGH+++V   + G      G ++DF E+K   
Sbjct: 1   MYEIVVRTSFAAAHSIKGYD--GPCSRMHGHTWLVEAVLRGGQLDQKGMLVDFKEVKNIL 58

Query: 63  KPTYERLDHHYLNDIPGL-----ENPTSEVLAKWIWDQVKPVVPLLSA------VMVKET 111
           +     LDH  LN+I        ++PT+E +A++++ ++KP +  L        V V E+
Sbjct: 59  RSAVGELDHQNLNEIKPFAGGSGDSPTAENIARYLFCRIKPEIVKLERNIHLAMVRVWES 118

Query: 112 CTAGCIY 118
            TA   Y
Sbjct: 119 DTAAASY 125


>UniRef50_B5YJJ7 6-pyruvoyl-tetrahydropterin synthase n=4 Tax=Bacteria
           RepID=B5YJJ7_THEYD
          Length = 122

 Score =  137 bits (346), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 40/124 (32%), Positives = 59/124 (47%), Gaps = 8/124 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F+AAH+L       KC  +HGH++ V +E+  E     G  +DF ELK   
Sbjct: 1   MYKLKIITGFDAAHQLKGYK--GKCENIHGHNWKVEVEVISEKLNEIGIALDFKELKKNV 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIW----DQVKPVVPLLSAVMVKETCTAGC 116
                +LDH ++N IP     NP+SE +A+WI+    D+    +  L +V V E+  A  
Sbjct: 59  DEVVSQLDHTFINQIPPFTQLNPSSENIARWIYMSLKDKFNTTLVRLYSVTVWESDYASA 118

Query: 117 IYRG 120
            Y  
Sbjct: 119 TYME 122


>UniRef50_C4V0R8 Possible 6-pyruvoyltetrahydropterin synthase n=1 Tax=Selenomonas
           flueggei ATCC 43531 RepID=C4V0R8_9FIRM
          Length = 126

 Score =  134 bits (339), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 42/126 (33%), Positives = 62/126 (49%), Gaps = 11/126 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL  +  FEAAHR+   P   KC RLHGH+++V     G      G +IDF   KAA 
Sbjct: 1   MYTLRVEGAFEAAHRVVGYP--GKCDRLHGHNWVVEAVFRGTELDGLGMLIDFKTAKAAL 58

Query: 63  KPTYERLDHHYLNDIPGLE---NPTSEVLAKWIWDQVKPVV------PLLSAVMVKETCT 113
               +  DH Y+N++P  +   NPT+E LA  I++++            L+A+ V E+  
Sbjct: 59  MAVLDAFDHRYINELPPFDGEVNPTAENLACIIYERLAARTEVMESSAHLAALTVWESPK 118

Query: 114 AGCIYR 119
           +   Y 
Sbjct: 119 SSVTYE 124


>UniRef50_C8R1L5 Putative uncharacterized protein n=1 Tax=Desulfurivibrio
           alkaliphilus AHT2 RepID=C8R1L5_9DELT
          Length = 123

 Score =  134 bits (339), Expect = 6e-31,   Method: Composition-based stats.
 Identities = 39/125 (31%), Positives = 61/125 (48%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +F    F + H L + P    C + HGH++ V++ +  +     G  +DF +LKAA 
Sbjct: 1   MYEVFTTTHFSSGHHLRNYP--GNCEKPHGHNWKVKVIMRADELDELGMALDFRDLKAAL 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
           K   + LDH  LN+ P    ENP+SE +A++I+ ++K  +         V V ET   G 
Sbjct: 59  KVIIDDLDHRDLNEHPAFQQENPSSENIARYIFAELKKSLSSDRYRPHKVTVLETDACGV 118

Query: 117 IYRGE 121
            Y  E
Sbjct: 119 SYSEE 123


>UniRef50_Q31FT9 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Gammaproteobacteria
           RepID=Q31FT9_THICR
          Length = 125

 Score =  134 bits (338), Expect = 9e-31,   Method: Composition-based stats.
 Identities = 36/124 (29%), Positives = 61/124 (49%), Gaps = 8/124 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F +AH L   P    C +LHGH++ + +++ G+     G ++DF E+K   
Sbjct: 4   QFVLKTLLDFASAHSLRGYP--GDCAKLHGHNWKIEVQVVGDKLNDIGMLVDFKEIKRHA 61

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
           K     LDH +LND P    +NPT+E +A++I+ Q++  +      + ++ V E      
Sbjct: 62  KEVISELDHTFLNDHPHFKEKNPTAENIAEYIYKQIQQRIQSSTVKMHSLTVWENDRNCV 121

Query: 117 IYRG 120
           IY  
Sbjct: 122 IYSE 125


>UniRef50_C5SC00 Putative uncharacterized protein n=1 Tax=Allochromatium vinosum DSM
           180 RepID=C5SC00_CHRVI
          Length = 364

 Score =  134 bits (337), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 61/115 (53%), Positives = 76/115 (66%), Gaps = 1/115 (0%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           L++ F FE+AHRLP+VPEGH CGR+HGH F V L    ++       IDF  L A + P 
Sbjct: 123 LWRRFRFESAHRLPNVPEGHPCGRMHGHGFEVILHADQDLGGQD-MGIDFDRLAALWTPL 181

Query: 66  YERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           ++ L    LNDIPGLENPTSE L+ WIW ++KP +P LS V V ET TAGC + G
Sbjct: 182 HDELHQVCLNDIPGLENPTSERLSSWIWSRLKPELPALSWVTVYETATAGCHFDG 236



 Score =  101 bits (252), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 46/117 (39%), Positives = 71/117 (60%), Gaps = 4/117 (3%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              ++K+  FEAA RL   PEG    RLHGHS+++RL +T  +D   GW +D+ ++K  F
Sbjct: 238 HYRIWKEQRFEAALRLERSPEGDARRRLHGHSYLLRLHLTAPLDQVLGWTVDYGDVKRLF 297

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           KP Y+RLDHH L+ + GLE  +P S  L +WI ++++  +P L  + ++ T   G  
Sbjct: 298 KPLYDRLDHHRLDALDGLEAADPGS--LIRWIRERIQDDLPELDRIDLQPTPGCGAS 352



 Score = 68.6 bits (167), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 39/109 (35%), Positives = 60/109 (55%), Gaps = 4/109 (3%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           FEAA R+  +PEGH+C RLHGHSF+ ++     +        +  +L+AA     E LD+
Sbjct: 13  FEAACRVDILPEGHRCRRLHGHSFLAQVRAELPLGWAGFPGAESDDLQAALACCVEPLDY 72

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
             LN I  +  PT E LA+W+ D++   VP +++V ++ T   G    G
Sbjct: 73  RDLNAILPI--PTDENLARWVRDRLD--VPGIASVGIQSTRDQGADLDG 117


>UniRef50_C8VWH9 Putative uncharacterized protein n=1 Tax=Desulfotomaculum
           acetoxidans DSM 771 RepID=C8VWH9_DESAS
          Length = 125

 Score =  134 bits (337), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 41/123 (33%), Positives = 59/123 (47%), Gaps = 8/123 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L     F++AH L   P   KC  +HGH++ + + + GE    TG +IDF+ELK   K
Sbjct: 5   FELKVTEHFDSAHYLREYP--GKCKNVHGHTWYIEVVLQGENLDSTGILIDFSELKGLIK 62

Query: 64  PTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCI 117
              E  DH  LN+    E  NPTSE LA++ + ++K  +      L  V V E+      
Sbjct: 63  NIIEPFDHQLLNEQVPFEVDNPTSENLARYFYHEIKKKLSDKPVKLVRVTVSESRATAAA 122

Query: 118 YRG 120
           Y  
Sbjct: 123 YFE 125


>UniRef50_C1SPF1 PreQ(0) biosynthesis protein QueD n=1 Tax=Denitrovibrio acetiphilus
           DSM 12809 RepID=C1SPF1_9BACT
          Length = 122

 Score =  133 bits (336), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 38/123 (30%), Positives = 55/123 (44%), Gaps = 6/123 (4%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    +F  AH L +     KC  LHGH++ V   + G+    T  ++DF  +K   
Sbjct: 1   MYKVRVVMSFGGAHNLRNY--NGKCENLHGHNWKVEAYLKGDELNETEMLVDFTIMKKRL 58

Query: 63  KPTYERLDHHYLNDIPGL---ENPTSEVLAKWIWDQVKPVVPLL-SAVMVKETCTAGCIY 118
           K   E LDH YLN+        NPTSE +A++I+  +K     L   V V ET      Y
Sbjct: 59  KEILETLDHKYLNEQVEFFKVNNPTSENIARYIYQGLKETFGKLTDRVAVWETDIQAAEY 118

Query: 119 RGE 121
             +
Sbjct: 119 WEQ 121


>UniRef50_B7K1S3 Queuosine biosynthesis protein QueD n=6 Tax=Cyanobacteria
           RepID=B7K1S3_CYAP8
          Length = 136

 Score =  133 bits (335), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 54/122 (44%), Positives = 80/122 (65%), Gaps = 8/122 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAELK 59
             +FK+F FEAAHRLPH     KC RLHGHS++ R+ + G+      P  G I+DF++++
Sbjct: 9   WLIFKEFRFEAAHRLPHYD--GKCHRLHGHSWVGRIYVQGDRLVKDGPKQGMIMDFSDIQ 66

Query: 60  AAFKPTYER-LDHHYLNDIPGLENPTSEVLAKWIWDQVKPV-VPLLSAVMVKETCTAGCI 117
              +P  E  LDH+YLN+  GLENPT E +A+WI+++++   +  L AV ++ETCT+G  
Sbjct: 67  RYLEPLLENFLDHYYLNETMGLENPTCEAVAQWIFEKLEKAGLQGLQAVEIQETCTSGVR 126

Query: 118 YR 119
           Y 
Sbjct: 127 YS 128


>UniRef50_B0VJG6 6-pyruvoyl tetrahydrobiopterin synthase family protein n=1
           Tax=Candidatus Cloacamonas acidaminovorans
           RepID=B0VJG6_9BACT
          Length = 126

 Score =  133 bits (335), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 41/125 (32%), Positives = 60/125 (48%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L    TF AAH L        C +LHGH++ VR+ +  +     G  +DF  LK   
Sbjct: 1   MFYLNVIETFSAAHLLRGYE--GACSKLHGHNWKVRVCVKTKEQDEIGMAMDFGVLKTIL 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
                 LDH YLN+I      NPTSE LAK+I++ ++  +      +S V V E+  +  
Sbjct: 59  SNILNNLDHSYLNEIVPFTERNPTSENLAKYIYECMEKELQDKPVAISEVEVYESEKSSV 118

Query: 117 IYRGE 121
           IY+ +
Sbjct: 119 IYKND 123


>UniRef50_B5YCT3 6-pyruvoyl-tetrahydropterin synthase n=24 Tax=Bacteria
           RepID=B5YCT3_DICT6
          Length = 125

 Score =  132 bits (333), Expect = 3e-30,   Method: Composition-based stats.
 Identities = 47/124 (37%), Positives = 68/124 (54%), Gaps = 11/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + + F F+AAH L       KC RLHGH++ + + + G  D   G IIDF ELK   
Sbjct: 1   MFVI-RKFKFDAAHNLESYK--GKCERLHGHTYRLVVIVEGIPDSE-GMIIDFVELKDIV 56

Query: 63  K-PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCI 117
           K    + LDH Y+N+I  ++ PT+E +A WIW +++  +      L  + V ET  +G I
Sbjct: 57  KREVIDILDHSYINEI--IKQPTAENIAIWIWQRLEEKLKRGNCHLYEIQVWETEDSGVI 114

Query: 118 YRGE 121
           YRGE
Sbjct: 115 YRGE 118


>UniRef50_B8FMW4 Queuosine biosynthesis protein QueD n=3 Tax=Proteobacteria
           RepID=B8FMW4_DESAA
          Length = 126

 Score =  130 bits (329), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 41/124 (33%), Positives = 59/124 (47%), Gaps = 8/124 (6%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++    F AAH L        C R+HGH++MV + I        G  IDF ++K A +
Sbjct: 5   FEIYVKTHFSAAHALTGYD--GDCSRIHGHNWMVEVSIQCRKLDDVGIGIDFKDVKDAVE 62

Query: 64  PTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCI 117
              + LDH  LND P  +  NPTSE +A +++ Q+   +      +S V V E   AG  
Sbjct: 63  EITQGLDHCMLNDHPAFQSVNPTSENVAMFLYKQLGSHLNNEYTKVSRVKVFEAPGAGAA 122

Query: 118 YRGE 121
           Y  E
Sbjct: 123 YWEE 126


>UniRef50_C6QCT4 Putative uncharacterized protein n=1 Tax=Hyphomicrobium
           denitrificans ATCC 51888 RepID=C6QCT4_9RHIZ
          Length = 140

 Score =  130 bits (329), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 56/118 (47%), Positives = 71/118 (60%), Gaps = 1/118 (0%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++KDF FEAAH LP    G    R+HGHSF  R+ + GE    TG+I  F EL +A +
Sbjct: 13  MQIYKDFRFEAAHFLPSAAPGTPNARVHGHSFRARVVVEGEPGRDTGYIFHFDELSSALR 72

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK-ETCTAGCIYRG 120
            T E LDH  LNDI GL  PT E +A WIW+++   VP L  V V  ++C  GC+YRG
Sbjct: 73  ETEEDLDHRMLNDIEGLSAPTLERIAMWIWNRLSNRVPGLVQVEVHRDSCNEGCVYRG 130


>UniRef50_Q55798 6-carboxy-5,6,7,8-tetrahydropterin synthase n=7 Tax=Bacteria
           RepID=QUED_SYNY3
          Length = 129

 Score =  130 bits (328), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 55/123 (44%), Positives = 76/123 (61%), Gaps = 8/123 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAEL 58
              ++K+F+FEAAH+LPH     KC RLHGHSF  R+ +  +        TG ++DF+ L
Sbjct: 1   MWIIYKEFSFEAAHQLPHHE--GKCRRLHGHSFRGRVYVASDRLKTTGSETGMVMDFSVL 58

Query: 59  KAAFKPTYE-RLDHHYLNDIPGLENPTSEVLAKWIWDQVKPV-VPLLSAVMVKETCTAGC 116
           KA   P  +  LDH+YLND  GLE+PTSE +A WI+ +++   VP L +V V ETCT+  
Sbjct: 59  KAHLDPLVKNHLDHYYLNDSLGLESPTSEAIAAWIFAKLEEAGVPGLHSVEVLETCTSAA 118

Query: 117 IYR 119
            Y 
Sbjct: 119 RYF 121


>UniRef50_Q03393 6-pyruvoyl tetrahydrobiopterin synthase n=19 Tax=Bilateria
           RepID=PTPS_HUMAN
          Length = 145

 Score =  130 bits (328), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 42/132 (31%), Positives = 71/132 (53%), Gaps = 16/132 (12%)

Query: 6   LFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           + +  +F A+HRL         ++    KC     HGH++ V + + GE+DP TG +++ 
Sbjct: 14  VSRRISFSASHRLYSKFLSDEENLKLFGKCNNPNGHGHNYKVVVTVHGEIDPATGMVMNL 73

Query: 56  AELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMVK 109
           A+LK   +    + LDH  L+ D+P   +   T+E +A +IWD ++ V+P  +L  V V 
Sbjct: 74  ADLKKYMEEAIMQPLDHKNLDMDVPYFADVVSTTENVAVYIWDNLQKVLPVGVLYKVKVY 133

Query: 110 ETCTAGCIYRGE 121
           ET     +Y+GE
Sbjct: 134 ETDNNIVVYKGE 145


>UniRef50_B1ZTR4 Putative uncharacterized protein n=3 Tax=Bacteria
           RepID=B1ZTR4_OPITP
          Length = 161

 Score =  130 bits (327), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 42/131 (32%), Positives = 61/131 (46%), Gaps = 16/131 (12%)

Query: 6   LFKDFTFEAAHRL--------PHVPEGHKCG--RLHGHSFMVRLEITGEVDPHTGWIIDF 55
           + +   F AAHRL         +  +   C     HGH++++ + + GE DP TG+I+D 
Sbjct: 24  ITRQVHFNAAHRLYNPTKSQAWNTNQYGLCTSPNWHGHNYVLEVTVRGEPDPETGYIVDL 83

Query: 56  AELKAAFKP-TYERLDHHYLNDIPGLEN---PTSEVLAKWIWDQVKPVVPL--LSAVMVK 109
           +ELK        +R DH  LND         PT+E L    WDQ++P +P   L  V + 
Sbjct: 84  SELKRVLHETVVDRCDHRNLNDDVDFLRNVIPTTENLVIAFWDQIEPALPAGKLHCVRLY 143

Query: 110 ETCTAGCIYRG 120
           ET      Y G
Sbjct: 144 ETPRNFAEYFG 154


>UniRef50_A6LBJ5 6-pyruvoyl-tetrahydropterin synthase n=43 Tax=Bacteria
           RepID=A6LBJ5_PARD8
          Length = 110

 Score =  130 bits (327), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 38/119 (31%), Positives = 59/119 (49%), Gaps = 9/119 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T+ K     A+H L  +    KC  LHGH++M+ +    +     G ++DF+ +K + 
Sbjct: 1   MYTVIKRMEISASHSLR-LSYPSKCENLHGHNWMITVYCRSKELNADGMVVDFSHIKRSV 59

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
           K     LDH  LNDI    NPT+E +A W+++Q+    P    V VKE+     IY  +
Sbjct: 60  KSL---LDHQNLNDILPF-NPTAENIAFWVYEQI----PSCFKVEVKESEGNTAIYEED 110


>UniRef50_A1HNF1 Putative uncharacterized protein n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HNF1_9FIRM
          Length = 130

 Score =  129 bits (326), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 38/127 (29%), Positives = 61/127 (48%), Gaps = 14/127 (11%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT------GEVDPHTGWIIDF 55
            +    K FTF+AAH LP      KC ++HGH++ + + +           P  G +IDF
Sbjct: 4   PTVRTTKIFTFDAAHFLPGHE--GKCAQMHGHTYRLEVTVERKDGGVATGGPEDGMVIDF 61

Query: 56  AELKAAFKP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKE 110
             L A  K    ++LDH  LND      PTSE +A+ I+ ++  ++      +  V++ E
Sbjct: 62  GRLSALIKDRVVDKLDHKVLNDCFPFR-PTSENMARHIFIELSAILANEDVNVVRVVLWE 120

Query: 111 TCTAGCI 117
           T T+   
Sbjct: 121 TPTSYVE 127


>UniRef50_B9K796 Queuosine biosynthesis protein QueD n=2 Tax=Bacteria
           RepID=B9K796_THENN
          Length = 131

 Score =  129 bits (325), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 48/123 (39%), Positives = 73/123 (59%), Gaps = 10/123 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L K F+FEAAH L  V    KC RLHGH++ + +++ G ++     ++DFAELK   +
Sbjct: 12  MVLVKKFSFEAAHNL--VKYHGKCERLHGHTYRLTVKVEGPLNEED-MVMDFAELKKMVE 68

Query: 64  P-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIY 118
               ++LDH YLN++   E PT+E +A WIW+Q+   +      L  + + ET T+G +Y
Sbjct: 69  DRVIKKLDHSYLNEL--FEQPTTERVAIWIWEQLSGPLRECGVRLVEIELWETETSGVVY 126

Query: 119 RGE 121
           RGE
Sbjct: 127 RGE 129


>UniRef50_Q3A420 6-pyruvoyl-tetrahydropterin synthase n=7 Tax=Bacteria
           RepID=Q3A420_PELCD
          Length = 122

 Score =  129 bits (325), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 34/124 (27%), Positives = 57/124 (45%), Gaps = 7/124 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F AAH L +      C  LHGH++ V + +        G  +DF  LK   
Sbjct: 1   MYRLMICTHFAAAHNLMNYQ--GDCENLHGHNWKVEVTVATRELDKAGLGVDFKILKKET 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL---LSAVMVKETCTAGCI 117
               + LDH YLND+P  +  +P+SE +A+++++++  V      +  V + E+  A   
Sbjct: 59  NRILDLLDHKYLNDLPFFKGISPSSENIARFVFEELSKVFQESVVVENVRIWESDNACAS 118

Query: 118 YRGE 121
           Y  +
Sbjct: 119 YSLD 122


>UniRef50_A8L9C2 Putative uncharacterized protein n=1 Tax=Frankia sp. EAN1pec
           RepID=A8L9C2_FRASN
          Length = 140

 Score =  128 bits (323), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 44/120 (36%), Positives = 62/120 (51%), Gaps = 6/120 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K FTF+AAH LP +P GHKC R+HGH++ V   +        G++ DF +L  A +
Sbjct: 16  FRIGKRFTFDAAHHLPSLPAGHKCSRVHGHTYTVEFVLAASELAGPGFVTDFGDLAVAGR 75

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-----LLSAVMVKETCTAGCIY 118
              E  DH  LN++  +E PTSE LA+ +       V       L AV V ET ++   Y
Sbjct: 76  YLAESFDHRDLNEVLDVE-PTSEALAQHLARWFLAEVEPGVHGRLVAVRVSETPSSWAEY 134


>UniRef50_Q90W95 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Deuterostomia
           RepID=PTPS_POERE
          Length = 147

 Score =  128 bits (322), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 38/133 (28%), Positives = 63/133 (47%), Gaps = 16/133 (12%)

Query: 5   TLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIID 54
            + +  +F A HRL         +     KC     HGH++ V + + G++DP TG +++
Sbjct: 15  YITRVQSFSACHRLHSLRLSDEENKEVYGKCNNPYGHGHNYKVEVTVRGKIDPVTGMVMN 74

Query: 55  FAELKAAFKPTYE-RLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMV 108
             +LK   +      LDH  L+ D+P   +   T+E LA +IWD +   +P      + +
Sbjct: 75  LTDLKKCIEEVIMIPLDHKNLDKDVPYFADVVSTTENLAVYIWDNMAKALPASLPYEIRI 134

Query: 109 KETCTAGCIYRGE 121
            ET     +YRGE
Sbjct: 135 HETDKNIVVYRGE 147


>UniRef50_C1A6G1 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1A6G1_GEMAT
          Length = 137

 Score =  128 bits (322), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 37/137 (27%), Positives = 61/137 (44%), Gaps = 16/137 (11%)

Query: 1   MMSTTLFKDFTFEAAHRLPHV--------PEGHKCGRL--HGHSFMVRLEITGEVDPHTG 50
           M   T+ +   F AAHR+ +             KC     HGH++ + + + G V   TG
Sbjct: 1   MPIVTVTRRLRFNAAHRVHNPALSDADNTRLFGKCNNPNWHGHNYTLDVSVRGPVAEDTG 60

Query: 51  WIIDFAELKAAF-KPTYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVV--PLLS 104
           ++ID   L+A   +    + DH   N D+P ++  NPT+E +   +W  + P +    L 
Sbjct: 61  YVIDLGALRAIVEREVLSQTDHRNFNIDVPYMQGINPTTENIVVAMWQVLGPAIAPATLQ 120

Query: 105 AVMVKETCTAGCIYRGE 121
            + + ET      Y GE
Sbjct: 121 RLRLWETENNYVDYSGE 137


>UniRef50_C0QLV0 PtpS n=8 Tax=cellular organisms RepID=C0QLV0_DESAH
          Length = 127

 Score =  128 bits (322), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 39/124 (31%), Positives = 61/124 (49%), Gaps = 10/124 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F AAH+L  V  G KC  LHGH++ V + + GE     G ++DF  +K   
Sbjct: 1   MFELKVKTHFAAAHKLAMV--GEKCENLHGHNWDVEVYVAGEQLNEAGVLVDFGVIKGFV 58

Query: 63  KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP------LLSAVMVKETCTA 114
           +   + LDH YLN++    +  P+SE +A +I +++KP +        +S V   E+  A
Sbjct: 59  RKIMKELDHKYLNELDAFADVQPSSEQIAIYIANRLKPSLKGFHPPVRVSRVSAWESANA 118

Query: 115 GCIY 118
              Y
Sbjct: 119 CATY 122


>UniRef50_B8J0W0 Queuosine biosynthesis protein QueD n=8 Tax=Desulfovibrionales
           RepID=B8J0W0_DESDA
          Length = 135

 Score =  127 bits (319), Expect = 1e-28,   Method: Composition-based stats.
 Identities = 43/128 (33%), Positives = 58/128 (45%), Gaps = 15/128 (11%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAF 62
             L     F A H L H     KC R+HGH+F V L + G    P T  ++DF  LK A 
Sbjct: 6   WRLTVRDDFSAGHALRHYE--GKCERMHGHNFAVELTVEGNRLAPQTEMLLDFKILKKAL 63

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----------LLSAVMVKE 110
           K   + LDH  LN+ P  +  NP+SE LA+ IW  ++ ++            L +V V E
Sbjct: 64  KAVLDALDHRLLNETPPFDRINPSSENLARHIWQGMEALLAEHEDPQARLVRLHSVTVSE 123

Query: 111 TCTAGCIY 118
                  Y
Sbjct: 124 KGAQSATY 131


>UniRef50_B8DNN3 Putative uncharacterized protein n=3 Tax=Desulfovibrio
           RepID=B8DNN3_DESVM
          Length = 130

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 39/124 (31%), Positives = 55/124 (44%), Gaps = 9/124 (7%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAF 62
             L     F A+H L H     KC  +HGH+F V +   G+     T  ++DF  LK   
Sbjct: 6   WRLTVRSEFCASHALRHYE--GKCESMHGHNFAVEMVAEGDRLTGDTEIVLDFKVLKREL 63

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
               + LDH  LND+   +  NP+SE L++ IW Q+ P +      L +V V E      
Sbjct: 64  NAVLDTLDHKNLNDVTPFDTINPSSENLSRHIWQQLAPRLAPHGVRLHSVTVSEKAAQSA 123

Query: 117 IYRG 120
            Y  
Sbjct: 124 TYME 127


>UniRef50_B5Y6S0 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Bacteria
           RepID=B5Y6S0_COPPD
          Length = 127

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 42/126 (33%), Positives = 70/126 (55%), Gaps = 10/126 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-HTGWIIDFAELKA 60
           M+  + K FTF+AAH L +     KC  LHGH++ + + + G  +    G ++DF +LK 
Sbjct: 1   MNVCVTKAFTFDAAHNLTNYK--GKCEALHGHTYRLEVTVCGTPNELENGLLMDFGDLKD 58

Query: 61  AF-KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAG 115
              K    +LDH YLND    E P++E++A W+++ +KP V      L++V + ET T+ 
Sbjct: 59  LVNKEVLSKLDHSYLNDH--FEQPSTELVAMWVFETLKPHVEKLGLVLTSVKLFETATSW 116

Query: 116 CIYRGE 121
              + +
Sbjct: 117 VEIKAD 122


>UniRef50_B1GYR9 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1GYR9_UNCTG
          Length = 122

 Score =  126 bits (318), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 7/121 (5%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L    +F +AH L       +C  LHGH++ +R    G     TG +IDF ++K  
Sbjct: 1   MKYKLSVTRSFSSAHCLREYK--GRCENLHGHNWKIRAAFYGTELDDTGVLIDFMDIKMH 58

Query: 62  FKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKP---VVPLLSAVMVKETCTAGC 116
                  LDH +LN+I   +  NPT+E +A +I  ++K        +  V + E+ ++  
Sbjct: 59  LNKVINYLDHKFLNEIVPFDRVNPTAENIAAFILGRLKDIETKNAKVCEVEIWESESSSA 118

Query: 117 I 117
           +
Sbjct: 119 V 119


>UniRef50_Q6ARY1 Related to 6-pyruvoyl tetrahydropterin synthase n=1
           Tax=Desulfotalea psychrophila RepID=Q6ARY1_DESPS
          Length = 136

 Score =  126 bits (317), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 38/132 (28%), Positives = 68/132 (51%), Gaps = 16/132 (12%)

Query: 1   MMSTTLFKDFTFEAAHRL--------PHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWI 52
           M   T+ K+F F+AAH+L         +     KC +LHGH++ +R+ ITG+V P  G +
Sbjct: 1   MAMLTITKEFRFDAAHKLFLKDLTDQENREAFGKCSQLHGHTYCLRITITGKVQP-NGMV 59

Query: 53  IDFAELKAAFKP-TYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP----LLSA 105
           ++F +LK   +     R DH +LN++    +   T+E ++ +I+  +   +      L+ 
Sbjct: 60  LNFTDLKQIVEEKIIARYDHSHLNELEEYRDLPTTAENMSLYIFKVLAACLKKQKVTLTE 119

Query: 106 VMVKETCTAGCI 117
           V + ET T+   
Sbjct: 120 VQLYETPTSWAT 131


>UniRef50_Q0BPQ0 Queuosine biosynthesis protein queD n=2 Tax=Proteobacteria
           RepID=Q0BPQ0_GRABC
          Length = 130

 Score =  125 bits (316), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 45/122 (36%), Positives = 65/122 (53%), Gaps = 2/122 (1%)

Query: 1   MMST-TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
           M     + K FTFEAAH L    E     R+HGHS+ V + + G VDP +G ++D   L+
Sbjct: 8   MPRVLEIGKQFTFEAAHTLHREIETDSSLRIHGHSYRVEVVLRGGVDPDSGMLMDLGLLQ 67

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIY 118
                  + LDH  L+++PGL   T E +A +IW  + P +P L+ V V ++T    C  
Sbjct: 68  RKMNAVRDALDHRLLDEVPGLAPATMENIALFIWRHLAPDLPALAEVSVFRDTLGERCTC 127

Query: 119 RG 120
           RG
Sbjct: 128 RG 129


>UniRef50_C0GP47 Queuosine biosynthesis protein QueD n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GP47_9DELT
          Length = 128

 Score =  125 bits (316), Expect = 3e-28,   Method: Composition-based stats.
 Identities = 46/126 (36%), Positives = 68/126 (53%), Gaps = 9/126 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELKA 60
               L     F ++H+L +   G KC  LHGH+F V++++ G EVDP TG ++DF ELK 
Sbjct: 4   PRYCLRVSSDFSSSHQLRNY--GGKCESLHGHNFQVQVQVCGKEVDPDTGMLMDFKELKN 61

Query: 61  AFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTA 114
                 E LDH +LND+P  +  NP+SE LA +++  +K  +      L  VMV E  ++
Sbjct: 62  TLLAVLEELDHKHLNDLPHFKETNPSSENLACFVYQGLKKSLGNRGVYLDWVMVAEKDSS 121

Query: 115 GCIYRG 120
              Y  
Sbjct: 122 RAYYSE 127


>UniRef50_B9EM09 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=Coelomata
           RepID=B9EM09_SALSA
          Length = 204

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 39/133 (29%), Positives = 63/133 (47%), Gaps = 17/133 (12%)

Query: 5   TLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIID 54
            + +  +F A HRL         +     KC     HGH++   + + G++D HTG +++
Sbjct: 73  YITRVQSFSACHRLHSPTLSDEVNKRIFGKCNNPNGHGHNYK-EVTVRGKIDRHTGMVMN 131

Query: 55  FAELKAAFKPTYE-RLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAVMV 108
             +LK   +      LDH  L+ D+P   N   T+E +A +IWD +   +P   L  V +
Sbjct: 132 ITDLKQHIEEVIMIPLDHKNLDKDVPYFANVVSTTENVAVYIWDNMVKQLPANLLYEVKI 191

Query: 109 KETCTAGCIYRGE 121
            ET     +YRGE
Sbjct: 192 HETDKNIVVYRGE 204


>UniRef50_B4RHW0 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Caulobacteraceae
           RepID=B4RHW0_PHEZH
          Length = 125

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 42/108 (38%), Positives = 55/108 (50%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
               + K  TF+AAH L   P       LHGHSF V   + G+     GW+ D A+L  A
Sbjct: 4   PVFEITKAATFDAAHYLAEGPAHRPYTNLHGHSFKVEATVRGQPQEPVGWVADLADLDEA 63

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
            K     LDH  LN+ PGLE PT E L  +  ++++P  P LS V+V 
Sbjct: 64  LKAVAGELDHGLLNEKPGLERPTLEHLCLYFAERLRPRFPGLSRVVVS 111


>UniRef50_D1B660 Putative uncharacterized protein n=1 Tax=Thermanaerovibrio
           acidaminovorans DSM 6589 RepID=D1B660_THEAS
          Length = 121

 Score =  125 bits (315), Expect = 4e-28,   Method: Composition-based stats.
 Identities = 43/123 (34%), Positives = 64/123 (52%), Gaps = 10/123 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L + F+F AAH LP      +C  LHGH++   + + G  DP  G I+DF ELK   +
Sbjct: 1   MKLKRRFSFSAAHWLPRYK--GRCEALHGHTYSFVITLEGSPDPE-GMIMDFTELKGLVE 57

Query: 64  P-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCIY 118
                RLDH  LND+  LE PT+E L++WI++ +   +      L +V V E+     ++
Sbjct: 58  EMVLSRLDHSCLNDL--LEQPTAEALSRWIFEALADRLEAPNRRLESVEVFESPDCSALF 115

Query: 119 RGE 121
             E
Sbjct: 116 LRE 118


>UniRef50_D2L9S0 Putative uncharacterized protein n=1 Tax=Desulfovibrio sp. FW1012B
           RepID=D2L9S0_9DELT
          Length = 124

 Score =  125 bits (314), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 44/122 (36%), Positives = 63/122 (51%), Gaps = 7/122 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
            T+     F AAHRLP  P    C  +HGH+F V + +T       G + DF +++AA  
Sbjct: 5   YTITVSGAFSAAHRLPDHP--GPCAFMHGHNFEVAVALTATAL-VRGMVADFLDVRAALD 61

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYR 119
             + RLDH  LNDIP L  PT+EVLA WI+ Q++  +      ++ V V E+      Y 
Sbjct: 62  AAFARLDHACLNDIPELSPPTAEVLAAWIFGQLRERLDDGRVRVARVTVTESAGLAATYA 121

Query: 120 GE 121
            +
Sbjct: 122 ED 123


>UniRef50_P48611 6-pyruvoyl tetrahydrobiopterin synthase n=16 Tax=Eumetazoa
           RepID=PTPS_DROME
          Length = 168

 Score =  125 bits (314), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 42/132 (31%), Positives = 63/132 (47%), Gaps = 17/132 (12%)

Query: 6   LFKDFTFEAAHRLP--------HVPEGHKCGRLHGH--SFMVRLEITGEVDPHTGWIIDF 55
           L +  TF A HRL         ++    KC   HGH  ++ V + + G +D  TG +++ 
Sbjct: 9   LTRRETFSACHRLHSPQLSDAENLEVFGKCNNFHGHGHNYTVEITVRGPIDRRTGMVLNI 68

Query: 56  AELKAAFKPTY-ERLDHHYLN-DIPGLENP--TSEVLAKWIWDQVKPVVPL---LSAVMV 108
            ELK A +    +RLDH  L+ D+    N   T+E LA +IWD ++  +     L  V +
Sbjct: 69  TELKEAIETVIMKRLDHKNLDKDVEYFANTPSTTENLAVYIWDNIRLQLKKPELLYEVKI 128

Query: 109 KETCTAGCIYRG 120
            ET      YRG
Sbjct: 129 HETPKNIISYRG 140


>UniRef50_D1NB55 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1NB55_9BACT
          Length = 123

 Score =  125 bits (314), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 32/125 (25%), Positives = 56/125 (44%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  D +F AAH+L        C +LHGH++ + + +        G  +DF +LKA  
Sbjct: 1   MFEIEIDRSFSAAHQLRGY--NGDCCKLHGHNYKITVTVRSSELDEIGIALDFKKLKAEL 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
                  DH  L+++   +  NPTSE LA+ I+ ++   +      +  V V E+  +  
Sbjct: 59  DALLAEYDHSNLSELADFQAVNPTSENLARTIYRKISEKMNSGTIRVHRVRVGESDHSAV 118

Query: 117 IYRGE 121
            Y  +
Sbjct: 119 TYFED 123


>UniRef50_Q30ZA2 6-pyruvoyl tetrahydrobiopterin synthase, putative n=3
           Tax=Desulfovibrionales RepID=Q30ZA2_DESDG
          Length = 130

 Score =  124 bits (313), Expect = 6e-28,   Method: Composition-based stats.
 Identities = 43/129 (33%), Positives = 59/129 (45%), Gaps = 11/129 (8%)

Query: 1   MMS--TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAE 57
           M      L     F AAH L +     KC  LHGH+F V   + G +  P T  ++DF  
Sbjct: 1   MPKGIWRLTVRSDFAAAHSLRNY--CGKCEALHGHNFGVEATVEGGILTPDTELLVDFKV 58

Query: 58  LKAAFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKET 111
           LK A K   + LDH  LN+ P  +  NP+SE LA+ I+  + P+V      + +V V E 
Sbjct: 59  LKNALKQVLDGLDHCVLNETPPFDTCNPSSENLARHIYRHMAPLVQPHGVRMHSVTVSEK 118

Query: 112 CTAGCIYRG 120
                 Y  
Sbjct: 119 QAQSATYME 127


>UniRef50_A2BZT2 6-pyruvoyl tetrahydropterin synthase n=48 Tax=cellular organisms
           RepID=A2BZT2_PROM1
          Length = 308

 Score =  123 bits (310), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 39/134 (29%), Positives = 60/134 (44%), Gaps = 18/134 (13%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L     F AAHRL         +     KC R   HGH+++V + + G+++P TG 
Sbjct: 152 MDAYLTVQTHFSAAHRLAREDLPQTENEKIFGKCARPNGHGHNYLVDITVKGKINPRTGM 211

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQV----KPVVPLL 103
           I D + L +       E  DH +LN DIP   N  PT+E +A  I D++      +   L
Sbjct: 212 ICDLSALNSLINDLVVEPFDHTFLNKDIPYFANCVPTAENIALHISDKLTNPINAIGANL 271

Query: 104 SAVMVKETCTAGCI 117
             + ++E+      
Sbjct: 272 YKIKLQESPNNAAE 285



 Score = 99.4 bits (247), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 32/134 (23%), Positives = 61/134 (45%), Gaps = 21/134 (15%)

Query: 6   LFKDFTFEAAH--RLP------HVPEGHKCG--RLHGHSFMVRLEITGEVDPHTGWIIDF 55
           + +   F A+H  RLP      +      C     HGH++ + + + G+     G +++ 
Sbjct: 18  ITRRACFSASHLYRLPELSDDDNSALFGPCSIAPGHGHNYELIVTMEGD-LNKYGMVLNL 76

Query: 56  AELK-AAFKPTYERLDHHYLNDI-PGLEN-------PTSEVLAKWIWDQVKPVVPLLSAV 106
           +++K A       +LD  +LND  P  +        PT+E L + IW+++K  +P L ++
Sbjct: 77  SDVKYAIKNEVTSQLDFRFLNDTWPEFDLSKPEGCLPTTESLVRIIWERLKSHLP-LKSL 135

Query: 107 MVKETCTAGCIYRG 120
            + E       Y+G
Sbjct: 136 RLYENPKLWADYQG 149


>UniRef50_C1TQH0 PreQ(0) biosynthesis protein QueD n=2 Tax=Bacteria
           RepID=C1TQH0_9BACT
          Length = 139

 Score =  123 bits (310), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 44/123 (35%), Positives = 63/123 (51%), Gaps = 10/123 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L K+FTF+AAHRL       KC  LHGH++ + + + G  D     + DF ELK    
Sbjct: 19  MLLRKEFTFDAAHRLERY--RGKCEALHGHTYRLAVTLNGRSDDED-MVFDFTELKRIVS 75

Query: 64  P-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCIY 118
                 LDH YLND+  ++ PT+E +A W+W ++   V      L +V + ET T+  I 
Sbjct: 76  EKILTELDHAYLNDV--MDQPTAENIALWVWRKLDESVKRPNCELHSVQIWETATSSVIV 133

Query: 119 RGE 121
             E
Sbjct: 134 FRE 136


>UniRef50_C1DVU3 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=Aquificales
           RepID=C1DVU3_SULAA
          Length = 115

 Score =  123 bits (309), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 40/110 (36%), Positives = 54/110 (49%), Gaps = 5/110 (4%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   +     F AAH L       K   LHGH++MV L I  +   + G   DF E+K  
Sbjct: 1   MPYIVRVKQKFNAAHFLTDY--HGKPEPLHGHTWMVELYIKADKLDNGGMGYDFLEIKDL 58

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKET 111
            K      D+  +NDI     P++E +AK+I+DQVK   P L  V+V ET
Sbjct: 59  LKEILP--DYKCMNDIYDFS-PSAENVAKYIYDQVKKKYPTLVKVVVWET 105


>UniRef50_A9AWJ6 Putative uncharacterized protein n=1 Tax=Herpetosiphon aurantiacus
           ATCC 23779 RepID=A9AWJ6_HERA2
          Length = 133

 Score =  122 bits (308), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 42/126 (33%), Positives = 65/126 (51%), Gaps = 13/126 (10%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-----HTGWIIDFA 56
           M   L K F FEAAH+LP+     KC RLHGHS+++ + + G + P       G +ID  
Sbjct: 1   MYAILTKQFRFEAAHQLPN--HRGKCARLHGHSYLLEVSVRGLIQPTRGQSDDGMVIDLE 58

Query: 57  ELKAAFKP-TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPL----LSAVMVKET 111
           ++K         R+DH+ LND   + + T+E +A W+WDQ++   P     L  + + ET
Sbjct: 59  QIKQLVNEIIIARVDHYNLNDFLSVPS-TAENIAHWMWDQLEQQAPEFAALLWRIRLWET 117

Query: 112 CTAGCI 117
            +    
Sbjct: 118 ASGYVE 123


>UniRef50_C7QN33 6-pyruvoyltetrahydropterin synthase n=3 Tax=Cyanobacteria
           RepID=C7QN33_CYAP0
          Length = 291

 Score =  122 bits (308), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 42/134 (31%), Positives = 62/134 (46%), Gaps = 18/134 (13%)

Query: 2   MSTTLFKDFTFEAAHRLP--------HVPEGHKCGRLHGH--SFMVRLEITGEVDPHTGW 51
           M  TL     F AAHRL         +     KC R+HGH  ++ + + +TGE+DP TG 
Sbjct: 134 MKATLTIQTHFSAAHRLALPELTLEQNSEIYGKCARIHGHGHNYHLEVSVTGEIDPRTGM 193

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV----PLL 103
           ++D   L+   K    E  DH +LN DIP      PT+E +A +I   ++  +      L
Sbjct: 194 LVDLGILQQVVKDYVVEPFDHTFLNKDIPYFAQVVPTAENIALYIAQLLQTPIQQLGAEL 253

Query: 104 SAVMVKETCTAGCI 117
             V + E+    C 
Sbjct: 254 DKVKLIESPNNSCE 267



 Score =  102 bits (254), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 35/133 (26%), Positives = 65/133 (48%), Gaps = 16/133 (12%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   + +   F A+HR          +  +   C R   HGH++++ + + GE+D + G 
Sbjct: 1   MQCVINRRAQFSASHRYWLSELDEQENRLKFGDCTRFPGHGHNYVLYVSLLGEIDSY-GM 59

Query: 52  IIDFAELKAAFKP-TYERLDHHYLNDI-PGLEN--PTSEVLAKWIWDQVKPVVPLLSAVM 107
           + + + +K   K     +LD+ YLND+    ++  PT+E LA+ IW ++ P +P L  + 
Sbjct: 60  VENLSTVKRVIKEEITSQLDYCYLNDVWEEFQDSLPTTENLARVIWQRLAPHLP-LVNIQ 118

Query: 108 VKETCTAGCIYRG 120
           + E       Y+G
Sbjct: 119 LFEHPQLWADYQG 131


>UniRef50_A7HXX3 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Parvibaculum
           lavamentivorans DS-1 RepID=A7HXX3_PARL1
          Length = 122

 Score =  121 bits (305), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 50/118 (42%), Positives = 71/118 (60%), Gaps = 1/118 (0%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K+F F+AAH LP+  EGH   R+HGHSF V + + G+    TG +  F +++    
Sbjct: 1   MKIYKEFLFDAAHFLPYAEEGHPNRRMHGHSFRVVVWLKGKPAAETGIVRHFEDVEREIM 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKE-TCTAGCIYRG 120
              E+LDHH LN+I GLE PT E +A WIWD +   +P ++ V V   +C  GCIY G
Sbjct: 61  AVREKLDHHLLNEIEGLEFPTLERIAAWIWDALATPLPEIARVEVHRASCREGCIYDG 118


>UniRef50_Q3SPB8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Alphaproteobacteria
           RepID=Q3SPB8_NITWN
          Length = 123

 Score =  121 bits (305), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 45/119 (37%), Positives = 61/119 (51%), Gaps = 2/119 (1%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L K F FEAAH LP    G     +HGHSF   + + G  DP +G ++D   L+   
Sbjct: 1   MWELTKSFRFEAAHALPGTTLGAASMEIHGHSFRAEVSLRGTPDPASGMVLDLGLLERGM 60

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK-ETCTAGCIYRG 120
                +LDH  LND+ GL  PT E LA++IWD V+     ++ V V  ++C   C Y G
Sbjct: 61  GEVRNKLDHKLLNDVEGLGPPTLENLARFIWDHVQHAGA-VTRVSVHRDSCGESCAYFG 118


>UniRef50_C1ZE85 PreQ(0) biosynthesis protein QueD n=2 Tax=Planctomycetaceae
           RepID=C1ZE85_PLALI
          Length = 136

 Score =  121 bits (305), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 35/135 (25%), Positives = 56/135 (41%), Gaps = 19/135 (14%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +  +  F   HRL +     KC  LHGH+    + + GE     G ++DF +LK   
Sbjct: 1   MFEVSSEIQFCYGHRLLNYS--GKCRHLHGHNGKAIITLAGESLDERGMLVDFGDLKRTV 58

Query: 63  -KPTYERLDHHYL------------NDIPGL----ENPTSEVLAKWIWDQVKPVVPLLSA 105
            +   + LDH  +            +    L    ENPT+E +AK I+++   V   +  
Sbjct: 59  SQWIDDHLDHRMVLCERDPMVKILRDAGEPLYLIPENPTAENIAKLIYEKTVEVGLPVIQ 118

Query: 106 VMVKETCTAGCIYRG 120
           V + ET     +YR 
Sbjct: 119 VGLWETAKNYAVYRE 133


>UniRef50_A9M1Z1 6-pyruvoyl tetrahydrobiopterin synthase, putative n=26
           Tax=Neisseria RepID=A9M1Z1_NEIM0
          Length = 140

 Score =  121 bits (305), Expect = 6e-27,   Method: Composition-based stats.
 Identities = 35/141 (24%), Positives = 63/141 (44%), Gaps = 26/141 (18%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV---DPHTGWIIDFAELKA 60
             + K FTF+++H L       KC  LHGH++ + + ++ +     P  G ++DF +LKA
Sbjct: 1   MKITKIFTFDSSHMLDGHD--GKCQNLHGHTYKLEITVSDDPVRGGPKDGMVMDFTDLKA 58

Query: 61  AFKP-TYERLDHHYLN-----------------DIPGLENP---TSEVLAKWIWDQVKPV 99
             K    +  DH ++                  ++  L  P   T+E +A  ++D++K  
Sbjct: 59  IVKQHITDPFDHAFIYHGGNGRESQIAALLEGWNMKTLRLPCRTTAENMAVEMYDRLKNA 118

Query: 100 VPLLSAVMVKETCTAGCIYRG 120
              +  V + ET T+   Y G
Sbjct: 119 GLNVCRVKLWETPTSCAEYEG 139


>UniRef50_A0M3Y1 Conserved tetrahydrobiopterin biosynthesis-like protein n=22
           Tax=Bacteroidetes RepID=A0M3Y1_GRAFK
          Length = 136

 Score =  121 bits (304), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 42/136 (30%), Positives = 65/136 (47%), Gaps = 16/136 (11%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRLH--GHSFMVRLEITGEVDPHTGW 51
           M  T+ +   F AAHRL         +     KC   H  GH++ + + +TGE DP TG+
Sbjct: 1   MRITVHRKAHFNAAHRLYRKDWDDERNFGVFGKCSNPHYHGHNYELIVSVTGEPDPETGF 60

Query: 52  IIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPLLS--A 105
           ++D   LK        E  DH  LN ++P  E+  PT+E +A  IW++++  +       
Sbjct: 61  VMDLKILKELIYLEVEEAFDHKNLNVEVPEFEDLIPTAEHIAVVIWNKLRTRIQEDHDLK 120

Query: 106 VMVKETCTAGCIYRGE 121
           V + ET      Y+GE
Sbjct: 121 VTLYETPRNFVSYKGE 136


>UniRef50_D1CA69 Putative uncharacterized protein n=1 Tax=Sphaerobacter thermophilus
           DSM 20745 RepID=D1CA69_SPHTD
          Length = 125

 Score =  120 bits (303), Expect = 9e-27,   Method: Composition-based stats.
 Identities = 33/125 (26%), Positives = 55/125 (44%), Gaps = 8/125 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +     FEAAHRL    +     RLHGH++ V +E+ G      G + D   LKA  
Sbjct: 1   MFAIGVVAQFEAAHRLRG--DFGPASRLHGHTYRVEVEVAGPQLNDDGTLFDLGLLKAWV 58

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGC 116
                 L++  L+ +P     N T+E +A+++ + + P +      +  V V E+  A  
Sbjct: 59  DEAVGELNYQNLDVLPAFAQRNSTAEEVARFLRETLAPRLHGKGLRMLTVRVWESPQAYA 118

Query: 117 IYRGE 121
             + E
Sbjct: 119 ACQWE 123


>UniRef50_B0SX52 Queuosine biosynthesis protein QueD n=1 Tax=Caulobacter sp. K31
           RepID=B0SX52_CAUSK
          Length = 121

 Score =  120 bits (302), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 41/106 (38%), Positives = 55/106 (51%), Gaps = 1/106 (0%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K  TF+AAH +   P  H+  +LHGHSF V   + G      GW+ D   L  A K
Sbjct: 5   FEITKAATFDAAHYIEQGPPDHRYRKLHGHSFKVEASVRG-ALQEAGWVADLDSLDGALK 63

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
                LDH  LND PGLE+PT E L  +  +++ P  P LS V++ 
Sbjct: 64  AVAAELDHGLLNDRPGLESPTLERLCLYFAERLTPRFPGLSRVVIS 109


>UniRef50_C7HJ58 6-pyruvoyl tetrahydropterin synthase n=4 Tax=Clostridia
           RepID=C7HJ58_CLOTM
          Length = 127

 Score =  119 bits (300), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 36/120 (30%), Positives = 64/120 (53%), Gaps = 9/120 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             ++ K FTF++AH L       KC  +HGH++ + + + G +    G ++DF +L+A  
Sbjct: 5   KVSITKLFTFDSAHHLIDY--NGKCRNIHGHTYKLEITLKG-LPDENGLVMDFHDLEAII 61

Query: 63  -KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCTAGCI 117
                E++DH YLND+    NPT E++  W+W+++   V      L  +++ ET T+   
Sbjct: 62  ENEVLEKVDHKYLNDVFDF-NPTCEMIGLWLWEEISKQVQNTRCTLEKLVLWETPTSYIT 120


>UniRef50_B5W8I5 Putative uncharacterized protein n=3 Tax=Cyanobacteria
           RepID=B5W8I5_SPIMA
          Length = 130

 Score =  119 bits (300), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 48/131 (36%), Positives = 66/131 (50%), Gaps = 12/131 (9%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD------PHTGWIID 54
           M    L  +FTF++AH +        CGRLHGH++ VR+E T          PH   + D
Sbjct: 1   MSKWKLTTEFTFDSAHYIKDY--NGPCGRLHGHTYKVRVEATSNQLHGSEFCPHPVMVAD 58

Query: 55  FAELKAAFKPTYE-RLDHHYLNDI-PGLENPTSEVLAKWIWDQVKPVVPL--LSAVMVKE 110
           F  L+ A K   +  LDH  LN+I P     T+E++AK+I+D+ K  VP      VMV E
Sbjct: 59  FRSLRWAKKDVSKGGLDHGLLNEILPPNYETTAEMIAKFIYDETKKRVPEGVQLKVMVSE 118

Query: 111 TCTAGCIYRGE 121
           T  +   Y  E
Sbjct: 119 TANSWVEYEDE 129


>UniRef50_Q1ZXI0 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Eukaryota
           RepID=PTPS_DICDI
          Length = 135

 Score =  119 bits (300), Expect = 2e-26,   Method: Composition-based stats.
 Identities = 42/131 (32%), Positives = 64/131 (48%), Gaps = 13/131 (9%)

Query: 4   TTLFKDFTFEAAHRL--------PHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDF 55
             L +   F ++HRL         +     KC   HGH++++ + I G V    G  ++ 
Sbjct: 5   VILTRREVFSSSHRLYSDKLSLEENKKIYGKCINSHGHNYVLEVSIKGAVKEDIGMFMNI 64

Query: 56  AELKAAFKP-TYERLDHHYL-NDIPGLEN--PTSEVLAKWIWDQVKPVVPL-LSAVMVKE 110
            ELK   K    ++LDH  L ND+P L+    T+E L+ +IWDQ+ P +   L  V + E
Sbjct: 65  TELKEILKEKVMDKLDHKNLENDVPELKGIVTTTENLSIFIWDQLFPSLKDFLYEVKILE 124

Query: 111 TCTAGCIYRGE 121
           T     +YRGE
Sbjct: 125 TENNFVVYRGE 135


>UniRef50_C6VZC4 Putative uncharacterized protein n=3 Tax=Sphingobacteriales
           RepID=C6VZC4_DYAFD
          Length = 138

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 39/129 (30%), Positives = 63/129 (48%), Gaps = 16/129 (12%)

Query: 6   LFKDFTFEAAHRLPHVPE--------GHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           +F+   F AAHRL +             KC     HGH++ + +++TG +DP TG+++D 
Sbjct: 7   VFRKEHFNAAHRLHNPAWSDEQNEAVFGKCNNPSFHGHNYELIVQVTGPLDPETGYVMDM 66

Query: 56  AELKAAFKP-TYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVV-PLLS-AVMVK 109
             L A  K    +R DH  LN D+   +  NPT+E +A  I+  ++P +   L   + + 
Sbjct: 67  KLLSAILKESVIDRFDHRNLNLDVEEFKTLNPTAENIAIVIYSIIRPKIDAGLDLKIRLY 126

Query: 110 ETCTAGCIY 118
           ET      Y
Sbjct: 127 ETERNFVEY 135


>UniRef50_UPI0001C378A0 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Ruminococcus
           flavefaciens FD-1 RepID=UPI0001C378A0
          Length = 165

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 34/140 (24%), Positives = 53/140 (37%), Gaps = 25/140 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH----TGWIIDFAEL 58
              L    +F++AH L       KC  +HGH + V + I G          G +IDF++L
Sbjct: 27  MYYLKTSASFDSAHFLAGYQ--GKCANIHGHRWKVEVSICGGSLQQEGTKRGMLIDFSDL 84

Query: 59  KAAFKPTYERLDHHYLNDIPGLEN-------------------PTSEVLAKWIWDQVKPV 99
           K A     +  DH  + +   L+                    PT+E  AK   + +   
Sbjct: 85  KKAVHDMADSFDHALIYETGSLKETTIAAMNDEGFHIIEVPFRPTAENFAKHFHELLTAK 144

Query: 100 VPLLSAVMVKETCTAGCIYR 119
              +S+V V ET     +Y 
Sbjct: 145 GLHISSVTVYETPDNCAVYE 164


>UniRef50_O31676 6-carboxy-5,6,7,8-tetrahydropterin synthase n=85 Tax=Bacillales
           RepID=QUED_BACSU
          Length = 146

 Score =  119 bits (299), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 42/129 (32%), Positives = 64/129 (49%), Gaps = 16/129 (12%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  L KD    AAH +P       C R+HGH++ V + + G+    +G++++F+ LK   
Sbjct: 14  SFELNKDMHISAAHFIPRESA-GACSRVHGHTYTVNITVAGDELDDSGFLVNFSVLKKL- 71

Query: 63  KPTYERLDHHYLNDIPGLEN------PTSEVLAKWIWDQVKPVV------PLLSAVMVKE 110
              +   DH  LND            PT+EV+AK I+D V+  +      P    V V+E
Sbjct: 72  --VHGNYDHTLLNDHEDFSQDDRYSLPTTEVVAKTIYDNVQAYLDTLENKPTCVQVFVRE 129

Query: 111 TCTAGCIYR 119
           T T+ C+YR
Sbjct: 130 TPTSYCVYR 138


>UniRef50_D0Y1P4 6-pyruvoyl tetrahydropterin synthase n=3 Tax=cellular organisms
           RepID=D0Y1P4_9CAUL
          Length = 121

 Score =  119 bits (298), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 43/108 (39%), Positives = 56/108 (51%), Gaps = 1/108 (0%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
               + K   F+AAH +   P  H+  +LHGHSF V   + GE+ P  GW+ D   L AA
Sbjct: 3   PVFEITKAAYFDAAHYIEQGPADHRYRKLHGHSFKVEASVKGEMAPA-GWVADLDSLDAA 61

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
            K     LDH  LND PGLE PT E L  +  +++K   P LS V + 
Sbjct: 62  LKAVAAELDHGLLNDKPGLETPTLERLCLYFAERLKVQFPGLSRVELS 109


>UniRef50_Q3B4V1 6-pyruvoyltetrahydropterin synthase n=11 Tax=Chlorobiaceae
           RepID=Q3B4V1_PELLD
          Length = 162

 Score =  118 bits (297), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 46/140 (32%), Positives = 64/140 (45%), Gaps = 21/140 (15%)

Query: 3   STTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWI 52
              + +   F AAHRL         +     KC     HGH++ + + + G VDP TG++
Sbjct: 23  KVYVTRTIEFNAAHRLFNPKFSEEMNTRVYGKCANKYGHGHNYQLEITLGGTVDPETGYL 82

Query: 53  IDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL------ 102
            D  ELK    +    R DH +LN D+P LE   PT+E LA  IWD ++  +        
Sbjct: 83  FDLKELKKILEEEVTARFDHRHLNHDVPELEGLVPTTETLAVLIWDILEERIAAIDNREI 142

Query: 103 -LSAVMVKETCTAGCIYRGE 121
            L AV + ET      Y GE
Sbjct: 143 SLQAVKLHETGKNSVSYLGE 162


>UniRef50_Q46G73 6-pyruvoyltetrahydropterin synthase n=7 Tax=Euryarchaeota
           RepID=Q46G73_METBF
          Length = 117

 Score =  118 bits (297), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 39/117 (33%), Positives = 54/117 (46%), Gaps = 6/117 (5%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    L      ++AH LP      KCGR+HGH++ + + + GEV    G +IDF +LK 
Sbjct: 1   MTKMRLGVIDYIDSAHYLPGH---GKCGRVHGHTYKIEVLVEGEV-RENGMVIDFYDLKK 56

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
             K T E  DH  LN+I     P+SE L + I  ++         V V E     C 
Sbjct: 57  GIKETLEEYDHILLNEILEF--PSSEHLCQHIHSRLYKRFGFPLQVRVWEGEGKWCE 111


>UniRef50_D0J5V8 6-pyruvoyl tetrahydropterin synthase and n=7 Tax=Comamonadaceae
           RepID=D0J5V8_COMTE
          Length = 121

 Score =  118 bits (296), Expect = 6e-26,   Method: Composition-based stats.
 Identities = 36/108 (33%), Positives = 59/108 (54%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M  T+ + F F+AAH L    E     R+HGH++   + + G  +P  G +ID   L+A 
Sbjct: 1   MQFTVHQRFFFDAAHTLERAIETESSRRIHGHTYWAEVSVRGPRNPDNGMVIDLGHLRAR 60

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
            +   ++LDHH+L+++PGL  PT E L  +I + +  + P  S + V 
Sbjct: 61  LELLRDQLDHHFLDEVPGLGKPTLENLCLFIANALADLEPAPSRIRVW 108


>UniRef50_Q63E30 6-pyruvoyl tetrahydrobiopterin synthase n=100 Tax=Bacilli
           RepID=Q63E30_BACCZ
          Length = 163

 Score =  118 bits (296), Expect = 6e-26,   Method: Composition-based stats.
 Identities = 41/131 (31%), Positives = 61/131 (46%), Gaps = 15/131 (11%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + K+FTF+AAH L       KC  LHGH++ V   I+G V    G  IDF ++K  +
Sbjct: 31  RVMVSKEFTFDAAHHLHCYE--GKCKNLHGHTYKVVFGISGYV-NEIGLAIDFGDIKEIW 87

Query: 63  K-PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV-----------PLLSAVMVKE 110
           K      LDH YLN+     N T+E +  WI++++   +             +  V + E
Sbjct: 88  KNEIEIYLDHRYLNETLPAMNTTAENMVVWIYEKMAEALTKDNRANEYKGARVEFVRLFE 147

Query: 111 TCTAGCIYRGE 121
           T T+    R E
Sbjct: 148 TPTSYAEVRRE 158


>UniRef50_D2R401 Putative uncharacterized protein n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R401_9PLAN
          Length = 169

 Score =  118 bits (296), Expect = 7e-26,   Method: Composition-based stats.
 Identities = 31/134 (23%), Positives = 50/134 (37%), Gaps = 19/134 (14%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + ++  F   HRL +     KC  LHGH+    + I      + G ++DF+++K    
Sbjct: 29  FRVSREIDFCYGHRLLNYD--GKCRHLHGHNGRAVITIESSSLDNRGMVMDFSDIKRVVS 86

Query: 64  PTYER-LDHHYL--NDIPGL--------------ENPTSEVLAKWIWDQVKPVVPLLSAV 106
              +  LDH  L     P +              ENPT+E + K I +        +   
Sbjct: 87  SWIDENLDHRMLLCKRDPYVQILKDLGEPLFLLDENPTAENICKLIHEFTASRGFPIVET 146

Query: 107 MVKETCTAGCIYRG 120
            + ET      YR 
Sbjct: 147 QLWETPHCFATYRA 160


>UniRef50_Q3J9J8 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Chromatiales
           RepID=Q3J9J8_NITOC
          Length = 99

 Score =  117 bits (295), Expect = 8e-26,   Method: Composition-based stats.
 Identities = 29/98 (29%), Positives = 53/98 (54%), Gaps = 6/98 (6%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLE--NPTSEV 87
           +HGH++ + +E+T +     G ++DF ++K + +    +LDH YLNDI   +  NPT+E 
Sbjct: 1   MHGHNWKLEVEVTAQALDQQGMVMDFKDIKESARELCAQLDHRYLNDISPFDLINPTAEN 60

Query: 88  LAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYRGE 121
           LA + +  +   +      +SA+ + ET  A   Y  +
Sbjct: 61  LAAFFYRGLSKQLNNERARVSAITLWETERACVRYTED 98


>UniRef50_O29809 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=1
           Tax=Archaeoglobus fulgidus RepID=QUED_ARCFU
          Length = 115

 Score =  117 bits (295), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 35/116 (30%), Positives = 55/116 (47%), Gaps = 6/116 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +    +F AAH +P      KCG++HGH+F V +EI+G+V    G ++DF +LK    
Sbjct: 5   MIIGISTSFSAAHSIPGHK---KCGKVHGHNFKVEVEISGKV-KENGMVMDFFDLKRIVN 60

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYR 119
               + DH  LN+   +  PTSE +   I+ ++      +  V V E        R
Sbjct: 61  EVVAKFDHTLLNEQIEI--PTSENICLRIFSELAEKGLNVRRVRVAENEDKWAEIR 114


>UniRef50_Q8Z0L1 Alr0080 protein n=5 Tax=Cyanobacteria RepID=Q8Z0L1_ANASP
          Length = 128

 Score =  117 bits (294), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 40/129 (31%), Positives = 63/129 (48%), Gaps = 12/129 (9%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD------PHTGWIID 54
           M    +  +F+F +AH +        CGR+HGH++ VR+E            PH   + D
Sbjct: 1   MPKWKVVTEFSFNSAHYIKDY--NGPCGRMHGHNYQVRIEAISTQLHSSQYCPHPVMVAD 58

Query: 55  FAELKAAFKPTYE-RLDHHYLNDI-PGLENPTSEVLAKWIWDQVKPVVP--LLSAVMVKE 110
           F  L+ A +   +  LDH  LN++ P     T+E++AK+I+D+ K  VP  +   V V E
Sbjct: 59  FRTLRWAKQDVTKGGLDHGILNEVMPPEYETTAEMIAKYIYDETKKRVPPDVQLKVNVSE 118

Query: 111 TCTAGCIYR 119
           T  +   Y 
Sbjct: 119 TPNSWVEYE 127


>UniRef50_A0Q1F5 6-pyruvoyl tetrahydrobiopterin synthase, putative n=5
           Tax=Clostridiales RepID=A0Q1F5_CLONN
          Length = 139

 Score =  117 bits (294), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 32/140 (22%), Positives = 54/140 (38%), Gaps = 25/140 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAEL 58
              L    +F++AH L       KC  +HGH + V +EI  E    TG     I+DF + 
Sbjct: 1   MYILKTKQSFDSAHFLSEYD--GKCSNIHGHRWTVEIEIQSETLNPTGKLKGMIVDFGDF 58

Query: 59  KAAFKPTYERLDHHYLND-----IPGLEN--------------PTSEVLAKWIWDQVKPV 99
           K   K   +  DH  + +     +  L+N              PT+E LA   ++ ++  
Sbjct: 59  KKDLKSIVDFYDHSLIIEQNSMKLEALDNLKNDGFRIIEVEFRPTAENLAHHFFNLMEQK 118

Query: 100 VPLLSAVMVKETCTAGCIYR 119
              +    + ET      ++
Sbjct: 119 GYNVRKSTIYETPNNCATFQ 138


>UniRef50_Q6B324 6-pyruvoyl tetrahydropterin synthase (Fragment) n=6 Tax=Eumetazoa
           RepID=Q6B324_DANRE
          Length = 143

 Score =  117 bits (293), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 37/130 (28%), Positives = 65/130 (50%), Gaps = 16/130 (12%)

Query: 6   LFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           + +  +F A HRL         +     KC     HGH++ V + + G++D +TG +++ 
Sbjct: 14  ITRVCSFSACHRLHSKCLSDEENKRTFGKCNNPNGHGHNYTVEVTVRGKIDKNTGMVMNL 73

Query: 56  AELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMVK 109
            +LK   +    + LDH  L+ D+P   +   T+E L+ +IWD ++ ++P   L  + V 
Sbjct: 74  TDLKEFIEEAVMKPLDHKNLDLDVPYFADVVSTTENLSVFIWDGLQKLLPHDSLYEIKVY 133

Query: 110 ETCTAGCIYR 119
           ET     IYR
Sbjct: 134 ETAKNIVIYR 143


>UniRef50_A8G2B1 6-pyruvoyl tetrahydropterin synthase n=3 Tax=Cyanobacteria
           RepID=A8G2B1_PROM2
          Length = 308

 Score =  116 bits (291), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 36/134 (26%), Positives = 58/134 (43%), Gaps = 18/134 (13%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L     F AAHRL         +     KC R+  HGH++ + + + G+++P TG 
Sbjct: 152 MEALLTVQSHFNAAHRLAKDEISLSENKKIYGKCARINGHGHNYFLDVTVRGQINPRTGM 211

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV----PLL 103
           I D   L++       E+ DH +LN DI   +   PT E +A  I D +   +      L
Sbjct: 212 ICDLPSLQSIIDDLIVEQFDHTFLNKDIEYFKTCVPTCENIALHISDILSSPIKNIGANL 271

Query: 104 SAVMVKETCTAGCI 117
             + ++E+      
Sbjct: 272 HKIRLQESPNNAAE 285



 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 21/134 (15%)

Query: 6   LFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           + +   F ++HR          ++    KC     HGH++ + + + GE     G +++ 
Sbjct: 18  ITRRACFSSSHRYWLPEKSPEENLSLFGKCSFAPGHGHNYELIVSMGGE-LDSDGMVLNL 76

Query: 56  AELKAAFK-PTYERLDHHYLNDIPGLEN--------PTSEVLAKWIWDQVKPVVPLLSAV 106
           +++K + K     +LD  +LND+    N        PT+E L K IW+++K  +P L+++
Sbjct: 77  SDVKHSIKNEVTGQLDFRFLNDVWPEFNIYSQDGILPTTEALVKVIWNRLKDDLP-LTSL 135

Query: 107 MVKETCTAGCIYRG 120
            + E+ T    Y G
Sbjct: 136 RLYESPTLWADYFG 149


>UniRef50_P44123 6-carboxy-5,6,7,8-tetrahydropterin synthase n=31
           Tax=Pasteurellaceae RepID=QUED_HAEIN
          Length = 141

 Score =  116 bits (291), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 35/143 (24%), Positives = 69/143 (48%), Gaps = 27/143 (18%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV---DPHTGWIIDFAELK 59
              + K+F+F+ AH L       KC  LHGH++ +++EI+G++         +IDF++LK
Sbjct: 1   MFKISKEFSFDMAHLLDGHD--GKCQNLHGHTYKLQVEISGDLYKSGAKKAMVIDFSDLK 58

Query: 60  AAFKPTY-ERLDHHYLNDIPGLEN--------------------PTSEVLAKWIWDQVKP 98
           +  K    + +DH ++ D                           T+E +A++I++++K 
Sbjct: 59  SIVKKVILDPMDHAFIYDQTNERESQIATLLQKLNSKTFGVPFRTTAEEIARFIFNRLKH 118

Query: 99  VVP-LLSAVMVKETCTAGCIYRG 120
                +S++ + ET T+ C Y+ 
Sbjct: 119 DEQLSISSIRLWETPTSFCEYQE 141


>UniRef50_C3KVW1 Queuosine biosynthesis protein QueD n=22 Tax=Bacteria
           RepID=C3KVW1_CLOB6
          Length = 143

 Score =  115 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 32/141 (22%), Positives = 52/141 (36%), Gaps = 25/141 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH----TGWIIDFAEL 58
              L  + +F++AH L       KCG +HGH + V++++  E         G IIDF +L
Sbjct: 1   MYILKAEHSFDSAHFLAGYE--GKCGNIHGHRWKVKIQVQAESLVQGGQLDGMIIDFGDL 58

Query: 59  KAAFKPTYERLDHHYLNDIPGLEN-------------------PTSEVLAKWIWDQVKPV 99
           K   K   +  DH  + +   +                     PT+E  A + +  +K  
Sbjct: 59  KKDVKSMVDYYDHALIIEKGTMREQSLNSLREDGFRIIEVNFRPTAENFALFFYKTMKDK 118

Query: 100 VPLLSAVMVKETCTAGCIYRG 120
              +    V ET      Y  
Sbjct: 119 GYNVKNSTVYETPNNSATYEE 139


>UniRef50_A0B6A5 Putative uncharacterized protein n=1 Tax=Methanosaeta thermophila
           PT RepID=A0B6A5_METTP
          Length = 120

 Score =  115 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 59/127 (46%), Gaps = 15/127 (11%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L     F+AAH LP      KC R+HGH++ V + + G+     G IIDF  LK  
Sbjct: 1   MRMGLS--MEFDAAHHLPMHD--GKCSRIHGHTYRVEVVLQGDPGDD-GMIIDFYMLKKI 55

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV--------PLLSAVMVKETCT 113
                + LDH+ LN +  L+NPT+E++A  I  ++   +          L +V + E   
Sbjct: 56  VGRVIQELDHNNLNTV--LQNPTAEMIASHIHRRLHEELKMTGLSDKATLLSVRLWEGRD 113

Query: 114 AGCIYRG 120
              +  G
Sbjct: 114 KWVMVDG 120


>UniRef50_O66626 6-carboxy-5,6,7,8-tetrahydropterin synthase n=8 Tax=Aquificales
           RepID=QUED_AQUAE
          Length = 162

 Score =  115 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 40/162 (24%), Positives = 68/162 (41%), Gaps = 42/162 (25%)

Query: 2   MSTTLFKDFTFEAAHRL-------------PHVPEGHKCGRLHGHSFMVRLEITGEVDPH 48
           M   + K F FEA HR+                   +KC  LHGHS+++ + +  +    
Sbjct: 1   MKWEISKTFRFEAGHRVWKQNLTYGRGAQFTKEKPVNKCVNLHGHSYVLEVTVGSDTLSE 60

Query: 49  TGWIIDFAELKAAFKPTYERLDHHYLNDI-----PGLEN----------------PTSEV 87
              ++DF  +K A K   E +DH ++ D+     P L++                PT+E 
Sbjct: 61  QDMVMDFYHVKNALKGLIEEIDHSFIIDVNDPMYPELKDVAEKYGAMKIFPVEFCPTAEA 120

Query: 88  LAKWIWDQVKPVVPL--------LSAVMVKETCTAGCIYRGE 121
           LAK+ +D +K  +          +  V++ ET T+   Y+ E
Sbjct: 121 LAKFFYDFLKKRLEEAGLLGEVKVVKVVLWETATSKAEYKEE 162


>UniRef50_B2KC64 Putative uncharacterized protein n=1 Tax=Elusimicrobium minutum
           Pei191 RepID=B2KC64_ELUMP
          Length = 115

 Score =  115 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 40/123 (32%), Positives = 58/123 (47%), Gaps = 13/123 (10%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   L +   F +AHRLP      +C  LHGH+++V   I GE    +G + DF  LK  
Sbjct: 1   MLLKLKRK--FSSAHRLPDYD--GECNNLHGHTWVVEFIIEGET-KESGMVEDFKTLKPL 55

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQ----VKPVVPLLSAVMVKETCTAGCI 117
                   DH YLND   ++NPT+E + K+I+D     +      L  V + E   A  I
Sbjct: 56  LDSVLP--DHKYLNDF--VQNPTAENMVKYIYDNAAKLLTQRGLKLKQVELWENENASAI 111

Query: 118 YRG 120
           ++ 
Sbjct: 112 FQA 114


>UniRef50_A2SD50 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=5
           Tax=Proteobacteria RepID=A2SD50_METPP
          Length = 129

 Score =  115 bits (290), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 42/121 (34%), Positives = 72/121 (59%), Gaps = 4/121 (3%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKC---GRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
              L + F FE+AH L    E ++     R+HGH++   + + GE DP TG ++D A L+
Sbjct: 1   MFELSQSFYFESAHTLRRQVERNEADGSRRVHGHTYTAEVTVRGEADPATGMVVDLALLR 60

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV-KETCTAGCIY 118
           +A     E+LDHH+L+++PGL  PT E L ++I +++   VP +++V V +++    C +
Sbjct: 61  SAIATVREQLDHHFLDEVPGLGLPTLENLCRFIHERLLTTVPAIASVSVGRQSSGDRCTF 120

Query: 119 R 119
           R
Sbjct: 121 R 121


>UniRef50_Q5KZY1 6-pyruvoyltetrahydropterin synthase(PTP synthase) n=7 Tax=Bacteria
           RepID=Q5KZY1_GEOKA
          Length = 134

 Score =  115 bits (289), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 14/128 (10%)

Query: 7   FKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDFA 56
            + + F +AHRL         +     KC     HGH++ + + + G+ DP TG +++ A
Sbjct: 2   TRRYYFSSAHRLHSDQLTNEENQRLFGKCNNRYGHGHNYCLEVTVIGKPDPITGMVVNLA 61

Query: 57  ELKAAF-KPTYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAVMVKETC 112
           EL     +    + DH +LN D    +  NPT+E +   IW+ + P +  L  + + ET 
Sbjct: 62  ELDEIVNREVLVKFDHKHLNLDTDEFKQINPTAENIVIVIWELLAPHLSSLYKIGLWETQ 121

Query: 113 TAGCIYRG 120
                Y G
Sbjct: 122 KNYFEYFG 129


>UniRef50_O02058 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=10
           Tax=Fungi/Metazoa group RepID=PTPS_CAEEL
          Length = 140

 Score =  115 bits (288), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 39/136 (28%), Positives = 69/136 (50%), Gaps = 16/136 (11%)

Query: 1   MMSTTLFKDFTFEAAHRLP--------HVPEGHKC--GRLHGHSFMVRLEITGEVDPHTG 50
           M   T+ +  +F AAHRL         +     KC     HGH+++ ++++ GEVDP +G
Sbjct: 4   MPIVTMERVDSFSAAHRLHSEKLSDAENKETFGKCNNSNGHGHNYVWKVKLRGEVDPTSG 63

Query: 51  WIIDFAELKAAFKPTYERLDHHYLN-DIPGLENP--TSEVLAKWIWDQVKPVVPL---LS 104
            + D A+LK       + +DH  L+ D+   +    TSE +A ++++++K V+     L 
Sbjct: 64  MVYDLAKLKKEMSLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMFEKLKSVMSNPSVLY 123

Query: 105 AVMVKETCTAGCIYRG 120
            V ++ET      Y+G
Sbjct: 124 KVTIEETPKNIFTYKG 139


>UniRef50_D2QJ42 Putative uncharacterized protein n=1 Tax=Spirosoma linguale DSM 74
           RepID=D2QJ42_9SPHI
          Length = 143

 Score =  115 bits (288), Expect = 5e-25,   Method: Composition-based stats.
 Identities = 34/133 (25%), Positives = 57/133 (42%), Gaps = 16/133 (12%)

Query: 2   MSTTLFKDFTFEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
               +F+   F AAHRL         +     KC     HGH++ + +++ G +D  TG+
Sbjct: 9   PRVAVFRKEHFNAAHRLNNPNWSDEKNTRVYGKCNNPNYHGHNYELIVQVIGPIDDETGY 68

Query: 52  IIDFAELKAAFKP-TYERLDHHYLN-DIPGLE--NPTSEVLAKWIWDQVKPVVPL--LSA 105
           +ID   L    K    +R DH  LN D       NP++E +A  I++ ++  +       
Sbjct: 69  VIDMKLLSDLIKEHVTDRFDHKNLNLDTEEFADLNPSAENIAIVIYNILRNQLSEGLDLK 128

Query: 106 VMVKETCTAGCIY 118
           + + ET      Y
Sbjct: 129 IRLYETERNFVEY 141


>UniRef50_UPI0001C1695B hypothetical protein CRD_00116 n=2 Tax=Nostocaceae
           RepID=UPI0001C1695B
          Length = 422

 Score =  115 bits (288), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 39/132 (29%), Positives = 61/132 (46%), Gaps = 13/132 (9%)

Query: 3   STTLFKDFTFEAAHRLP---HVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
             +L     F AAHRL       +  KC R HGH++ + + + GE+D  TG I+D   L 
Sbjct: 135 KISLTARSHFSAAHRLAPNLRAEKYGKCTRTHGHNYHLEVTVEGEMDGRTGTIVDLGCLH 194

Query: 60  AAF-KPTYERLDHHYLN-DIPGLEN----PTSEVLAKWIWDQVKPVVPL----LSAVMVK 109
               +   E  DH  +N DIP        PT+E +A+++ D ++  +      LS V + 
Sbjct: 195 ETVEREILELFDHSCINEDIPYFSTSHIVPTTENIARYMSDLLQFPISELGVKLSRVKLF 254

Query: 110 ETCTAGCIYRGE 121
           E+      Y G+
Sbjct: 255 ESDHLWVEYEGK 266



 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 36/124 (29%), Positives = 57/124 (45%), Gaps = 18/124 (14%)

Query: 12  FEAAHRL--------PHVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL         +     KC R+  HGH++ + + + GE+D  TG  +D   L   
Sbjct: 278 FSAAHRLADPTLSLEKNQTIYGKCSRINGHGHNYHLEVTVRGEIDSVTGMSVDLVGLNQI 337

Query: 62  FKP-TYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQ----VKPVVPLLSAVMVKETCT 113
            +    E +DH +LN D+P      PT+E +A +I D     ++ +   L  V + E+  
Sbjct: 338 IQHYVIEPMDHSFLNQDLPYFTEVVPTAENIAVYISDVVRSPIEELGAKLHKVKLIESPN 397

Query: 114 AGCI 117
             C 
Sbjct: 398 NSCE 401



 Score = 98.3 bits (244), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 33/134 (24%), Positives = 64/134 (47%), Gaps = 16/134 (11%)

Query: 2   MSTTLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   + +   F A+HR          +V +   C +   HGH++++ + ++GE     G 
Sbjct: 1   MECIINRRAQFSASHRYWLPELGEAQNVGKFGLCAKFPGHGHNYVLFISMSGE-LDEYGM 59

Query: 52  IIDFAELKAAFK-PTYERLDHHYLNDI-PGLEN--PTSEVLAKWIWDQVKPVVPLLSAVM 107
           +++ +++K   K      LD  YLN++    +   PT+E +A+ IW+++ P +P L  V 
Sbjct: 60  VLNLSDVKQVIKSEVTSELDFSYLNEVWEEFQATLPTTENIARVIWNRLTPHLP-LVRVQ 118

Query: 108 VKETCTAGCIYRGE 121
           + E       Y G+
Sbjct: 119 LFEHPQLWTEYEGK 132


>UniRef50_Q7NSB8 Probable 6-pyruvoyltetrahydrobiopterin synthase n=1
           Tax=Chromobacterium violaceum RepID=Q7NSB8_CHRVO
          Length = 239

 Score =  115 bits (288), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 58/111 (52%), Positives = 72/111 (64%), Gaps = 7/111 (6%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
           +FEAAH LPHVP GHKCGRLHGH F VR+                 EL  A+ P + RL+
Sbjct: 15  SFEAAHHLPHVPPGHKCGRLHGHGFGVRIVADAAQCGQR-------ELARAWAPLHRRLN 67

Query: 71  HHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRGE 121
           HHYLNDI GL+NPTSEVLA+W+  Q+   VP L+ V V+ET +AG  + G+
Sbjct: 68  HHYLNDIAGLDNPTSEVLAQWLHQQLSDAVPGLAWVEVRETHSAGSQFDGK 118



 Score = 81.3 bits (200), Expect = 9e-15,   Method: Composition-based stats.
 Identities = 40/114 (35%), Positives = 65/114 (57%), Gaps = 6/114 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K+  FE+A            G   GHS++VRL ++G +D   GW++DF ++K  FK
Sbjct: 120 FRIWKEQRFESA------IPFDADGNYTGHSYLVRLMLSGGIDRTMGWLLDFGDVKDRFK 173

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           P Y +LDH+ L+ + G+    S  +A+WI  Q+ P+VP LS + + E+  AG  
Sbjct: 174 PIYRQLDHNPLDKLAGVRGADSAAVAEWIHAQLSPLVPELSRIDLMESDDAGVS 227


>UniRef50_B5JVD7 Probable 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=gamma
           proteobacterium HTCC5015 RepID=B5JVD7_9GAMM
          Length = 332

 Score =  115 bits (288), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 61/121 (50%), Positives = 75/121 (61%), Gaps = 8/121 (6%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M  +  ++ + FEAAH LP+VPEGHKCGRLHGH F V L           W  +   L  
Sbjct: 96  MGDSYQWRRYRFEAAHFLPNVPEGHKCGRLHGHGFEVTL------LAPLRWSAE--SLDE 147

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            ++P YERL  H LN I GLENPTSEVLA+WIW Q+   +  L +V V+ET TAGC Y G
Sbjct: 148 HWQPLYERLHGHCLNRIVGLENPTSEVLAEWIWRQLIDSITDLLSVDVRETVTAGCRYDG 207

Query: 121 E 121
           +
Sbjct: 208 Q 208



 Score = 78.2 bits (192), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 35/113 (30%), Positives = 55/113 (48%), Gaps = 6/113 (5%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
            ++K    E A +L    E        GHS+ VRL +   +D   GW  D+ ++K  F+P
Sbjct: 211 RIWKQQEAECAVQLAGFDEPM------GHSYRVRLHLEAPLDKVMGWTQDYGDVKTQFQP 264

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
            Y +LDHH LN+I     P+   +A+W+   +   +P L+ + V  T   G I
Sbjct: 265 LYRQLDHHCLNEILPSGEPSDLAVAEWLRQGLGEALPALNRIDVHSTPEEGAI 317


>UniRef50_B9Z1F8 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Neisseriaceae
           RepID=B9Z1F8_9NEIS
          Length = 341

 Score =  114 bits (286), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 58/109 (53%), Positives = 71/109 (65%), Gaps = 7/109 (6%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDH 71
           FEAAH+LPHVP GHKCGRLHGH F VRL        H        +L AA+   + RL+H
Sbjct: 118 FEAAHQLPHVPAGHKCGRLHGHGFGVRLVADAASANHV-------DLAAAWGRLFLRLNH 170

Query: 72  HYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
            YLNDIPGL NPTSEVLA+WI+ ++   +  L+ V V+ET TAG  + G
Sbjct: 171 RYLNDIPGLANPTSEVLAQWIYRELSADLAGLAWVEVRETHTAGSQFDG 219



 Score = 76.3 bits (187), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 37/114 (32%), Positives = 63/114 (55%), Gaps = 6/114 (5%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             ++K+  FE+A            G   GHS+++RL + GE+D   GW++DF ++K  FK
Sbjct: 222 FRIWKEQHFESA------VPFDADGNYTGHSYLIRLMLQGELDGAMGWLLDFGDVKDRFK 275

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           P Y +LDH+ L+ + G+ N     +A+W+  ++ P+VP L+ V + E    G  
Sbjct: 276 PVYRQLDHNPLDRLAGIRNGHPASVAEWVHAELSPLVPELARVDLMERDERGVS 329


>UniRef50_C0N3T5 6-pyruvoyl tetrahydropterin synthase superfamily n=2
           Tax=Gammaproteobacteria RepID=C0N3T5_9GAMM
          Length = 98

 Score =  114 bits (286), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 31/98 (31%), Positives = 52/98 (53%), Gaps = 6/98 (6%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGLE--NPTSEV 87
           +HGH++ + +E+T       G  +DF  +K A +   + LDH YLNDIP  +  NPT+E 
Sbjct: 1   MHGHNWKLEVEVTATALNEHGMGMDFKTIKTAARELAKTLDHRYLNDIPPFDTVNPTAEN 60

Query: 88  LAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYRGE 121
           +A++ + ++   +      +S V + ET  A   Y  E
Sbjct: 61  IAQYFYQKLSGTLNNETAKISGVTLWETDRACVKYSEE 98


>UniRef50_A3UD70 6-pyruvoyl tetrahydrobiopterin synthase, putative n=1
           Tax=Oceanicaulis alexandrii HTCC2633 RepID=A3UD70_9RHOB
          Length = 132

 Score =  114 bits (286), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 41/107 (38%), Positives = 65/107 (60%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              + KDFTF+AAH   H    H   R+HGHSF   + +TG     +G + DF E++A  
Sbjct: 13  HLEISKDFTFDAAHHFEHKDANHPFSRMHGHSFAGTVTLTGSRAAESGMVKDFWEIEAEI 72

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVK 109
               E+LDH  LND+ GLE+P+ E +A W++++++  +P L+AV ++
Sbjct: 73  NKIREQLDHRLLNDVEGLEHPSLEAIAYWVFERLEKTLPGLTAVEIR 119


>UniRef50_A6LWG4 6-pyruvoyl tetrahydrobiopterin synthase, putative n=4
           Tax=Clostridium RepID=A6LWG4_CLOB8
          Length = 142

 Score =  114 bits (285), Expect = 1e-24,   Method: Composition-based stats.
 Identities = 31/144 (21%), Positives = 55/144 (38%), Gaps = 27/144 (18%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAEL 58
              +  +  F+ AH L       KC  +HGH + +  ++  E     G     + DF   
Sbjct: 1   MFKIKSEVQFDMAHYLSGYE--GKCSNIHGHRYKLIAKLKSEKLHQDGQLRGMVDDFGNF 58

Query: 59  KAAFKPTYERLDHHYLND-----------IPGLEN----------PTSEVLAKWIWDQVK 97
           K   K   E  DH  + +           +  L+N          PT+E +++ I++++K
Sbjct: 59  KNILKEIAETFDHKLIIENNEDGKALVKNLEELQNNFNIYLVDYRPTAEEMSRDIFNRLK 118

Query: 98  PVVPLLSAVMVKETCTAGCIYRGE 121
                +  V + ET    CIY  +
Sbjct: 119 AKGLSVCEVELFETPNNSCIYTED 142


>UniRef50_Q1IPI9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Acidobacteria
           RepID=Q1IPI9_ACIBL
          Length = 137

 Score =  113 bits (283), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 36/136 (26%), Positives = 62/136 (45%), Gaps = 16/136 (11%)

Query: 2   MSTTLFKDFTFEAAHRLPHVP--------EGHKC--GRLHGHSFMVRLEITGEVDPHTGW 51
           M   L +   F A+H   +             KC     HGH++ + + + G VD  TG+
Sbjct: 1   MVVYLTRKSEFSASHHYHNPDFTAEENLRVFGKCNNSNGHGHNYTLEVTVKGTVDATTGF 60

Query: 52  IIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVV--PLLSA 105
           ++D  +LK    +   + +DH YLN ++P  ++  PT+E +A  IW +++  +    L  
Sbjct: 61  VVDLKQLKEIMNREVVDAMDHRYLNHEVPEFKSQIPTTENIAIAIWKRLEGKLHVAKLHR 120

Query: 106 VMVKETCTAGCIYRGE 121
           V + E       Y GE
Sbjct: 121 VRLYEMHDLWVDYLGE 136


>UniRef50_A3EQ19 Probable 6-pyruvoyl tetrahydrobiopterin synthase family protein n=3
           Tax=Leptospirillum RepID=A3EQ19_9BACT
          Length = 128

 Score =  113 bits (283), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 39/127 (30%), Positives = 58/127 (45%), Gaps = 11/127 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +    TF A+H LP  P    C +LHGH++ V +  +       G  +DF E +A  
Sbjct: 1   MFLISVTATFAASHILPGYP--GLCSKLHGHNWTVEVSWSSRGLDPLGMALDFHEAEALL 58

Query: 63  KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP-------LLSAVMVKETCT 113
            P  + LDH +LND P      PTSE +A +++ ++K ++         L  V V E   
Sbjct: 59  GPLIKELDHSHLNDHPFFRERLPTSEQVAFFLYTRLKEIMSSRTDSTVRLDQVAVTEMAP 118

Query: 114 AGCIYRG 120
              IYR 
Sbjct: 119 YKAIYRE 125


>UniRef50_C4XPJ5 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Desulfovibrio magneticus RS-1 RepID=C4XPJ5_DESMR
          Length = 123

 Score =  112 bits (282), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 3/99 (3%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              T+     F AAHRLP  P    C  +HGH+F V  EI  +     G + DF +++ A
Sbjct: 3   PIYTIAVAGDFSAAHRLPGHP--GPCAAMHGHNFQVTAEICADSLI-NGMVADFLDVRTA 59

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVV 100
               +  LDH  LND+P L+ PT+EVLA +I  ++K  +
Sbjct: 60  MDAIFADLDHACLNDVPALDPPTAEVLAGYILSRLKARL 98


>UniRef50_C2D910 Possible 6-pyruvoyltetrahydropterin synthase n=1 Tax=Atopobium
           vaginae DSM 15829 RepID=C2D910_9ACTN
          Length = 154

 Score =  112 bits (282), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 35/142 (24%), Positives = 54/142 (38%), Gaps = 25/142 (17%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAE 57
           M  +L     F AAH L +     KC  LHGH + V + +  E     G     +IDF E
Sbjct: 15  MGFSLKTQSYFNAAHFLTNYK--GKCENLHGHRWQVIVYLYKENLSSQGEDKDMLIDFGE 72

Query: 58  LKAAFKPTYERLDHHYLND--------IPGLEN-----------PTSEVLAKWIWDQVKP 98
            K   +   ++ DH ++ +        +  LE             TSE  A++ + +   
Sbjct: 73  FKQIVRAEVKKFDHTFIVEENSLHPETVRALEQETFKLTFVPFRTTSENFARYFYQRFCA 132

Query: 99  VVPLLSAVMVKETCTAGCIYRG 120
           +   +  V V ET     IY  
Sbjct: 133 LGLPVVRVEVDETPHNCAIYEA 154


>UniRef50_C1CXM4 Putative 6-pyruvoyl tetrahydrobiopterin synthase, (PTP synthase)
           n=3 Tax=Bacteria RepID=C1CXM4_DEIDV
          Length = 136

 Score =  112 bits (281), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 21/138 (15%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG------WIIDF 55
           M  TL  +FTF++AH +        CGRLHGH++ VR+E+T      +        + DF
Sbjct: 1   MPWTLRTEFTFDSAHVIAGYD--GPCGRLHGHTYRVRMELTSSRLRPSAHVRRNIMVADF 58

Query: 56  AELKAAFKPTY-ERLDHHYLNDIPGL-ENPTSEVLAKWIWDQVKPVVPL----------- 102
             LK A K      LDH YLND+P L ++ T+EV+A +I  +    V             
Sbjct: 59  RTLKWAKKDVTGGGLDHTYLNDVPELGDDTTAEVIAAYIHRKTMERVRADLEPGDDGADL 118

Query: 103 LSAVMVKETCTAGCIYRG 120
              V + ET  + C Y  
Sbjct: 119 KLKVTLWETPDSSCEYWE 136


>UniRef50_A1WW30 Putative uncharacterized protein n=1 Tax=Halorhodospira halophila
           SL1 RepID=A1WW30_HALHL
          Length = 258

 Score =  112 bits (281), Expect = 4e-24,   Method: Composition-based stats.
 Identities = 53/114 (46%), Positives = 70/114 (61%), Gaps = 11/114 (9%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTY 66
           ++ F FEAAHRLP+VPEGH CGR+HGH ++V LE  G          D   L  A+ P  
Sbjct: 38  WRAFRFEAAHRLPYVPEGHPCGRMHGHGYLVVLEAAGG---------DPEALGEAWAPLG 88

Query: 67  ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIYRG 120
           + LD   LND   L+NPTSE++A W+W+Q++P  P L  + V ET  +GC Y G
Sbjct: 89  QALDRACLNDF--LDNPTSELIAVWLWEQLRPRCPGLIRLHVHETEHSGCTYDG 140



 Score = 67.4 bits (164), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 40/113 (35%), Positives = 57/113 (50%), Gaps = 2/113 (1%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
           T++K   FEAA  +    +     RLHGH + +R+ +T  +D   GW +D+ ++KAAF P
Sbjct: 144 TIWKAQRFEAATCVADADDTR--ARLHGHGYRLRVHVTAPLDRVLGWTLDYGDVKAAFAP 201

Query: 65  TYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
             E LDH  L+ I GLE+     LA W     +  +P L  V   E    G I
Sbjct: 202 VREALDHQRLDTIAGLESGDVASLAAWAARAARQRLPELLRVDCYERDGVGAI 254


>UniRef50_A1SFN0 Putative uncharacterized protein n=1 Tax=Nocardioides sp. JS614
           RepID=A1SFN0_NOCSJ
          Length = 118

 Score =  110 bits (277), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 9/122 (7%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M  ++ + + FEAAH LP  P   KC R+HGHS+++ + +TGE     G ++DFAE+ A 
Sbjct: 1   MRISIVRRYRFEAAHTLPWHP--GKCSRIHGHSYVLEVHVTGE-LDDRGVVMDFAEVDAI 57

Query: 62  FKPTY----ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
                      LDH  LN +  LENPT+E++A  I +++       + + + ET     +
Sbjct: 58  VDQHVLEGPAGLDHVDLNAL--LENPTAELVAVHIGERLDAAGLSWTMLRLWETEDGSVV 115

Query: 118 YR 119
             
Sbjct: 116 IE 117


>UniRef50_C5A6K8 6-pyruvoyl tetrahydrobiopterin synthase (PtpS) n=9
           Tax=Thermococcaceae RepID=C5A6K8_THEGJ
          Length = 115

 Score =  110 bits (276), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 35/119 (29%), Positives = 56/119 (47%), Gaps = 10/119 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + + F FEAAH +       +   +HGH+F + + + G +    G+++DF +L+  
Sbjct: 1   MRARIIERFKFEAAHSVV---VEGRPEEIHGHTFRLEVVVEGPL--KNGYVMDFIQLRKI 55

Query: 62  FKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP---LLSAVMVKETCTAGCI 117
                 +LDH  LN I   ENPT+E LA WI  +    +P    L  + + E    G  
Sbjct: 56  VGGIIGKLDHRNLNHI--FENPTTENLALWIAKETSRNLPEGVRLKRLTLWEGDDNGVE 112


>UniRef50_B8G7W6 Putative 6-pyruvoyl tetrahydropterin synthase n=5 Tax=Bacteria
           RepID=B8G7W6_CHLAD
          Length = 130

 Score =  110 bits (276), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 52/124 (41%), Gaps = 8/124 (6%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +     FEAAHRL          R+HGH++ +   +TGE     G ++D ++L+AA 
Sbjct: 1   MYEIGVSAQFEAAHRLEG--NFGPATRMHGHTYRLEAIVTGERLQPDGTLVDMSQLQAAV 58

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGC 116
           +     L +  L  + GL   N T+E +A + W ++   +         V + E      
Sbjct: 59  QRVVADLHYRDLGTVEGLRDINTTAEHVAYYCWRRIAAALSGAGLTTLTVRIWENPQVYA 118

Query: 117 IYRG 120
            Y  
Sbjct: 119 AYSE 122


>UniRef50_B4D1V3 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Chthoniobacter flavus Ellin428 RepID=B4D1V3_9BACT
          Length = 151

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 37/153 (24%), Positives = 51/153 (33%), Gaps = 36/153 (23%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K    E  H L   P+  KC   HGH+  V   +          + DF  +K A
Sbjct: 1   MPYRICKTIDIENGHMLSKHPD--KCQFPHGHTRKVEFVLEAAELDRNEMVCDFKIIKDA 58

Query: 62  FKPTYERLDH----------------HYLNDIPGLEN--PTSEVLAKWIWDQVKPVV--- 100
                +  DH                 Y + + G EN  PT+EVLA+ I+D     +   
Sbjct: 59  VGQWLDTFDHALCMNTSDPAYAEFKQRYGDRVIGFENQDPTTEVLARTIFDHASKALSAY 118

Query: 101 -------------PLLSAVMVKETCTAGCIYRG 120
                          L  V V ET T+   Y  
Sbjct: 119 SQKQDSRYPLRLDARLVTVRVWETATSWAEYAE 151


>UniRef50_A3ZTI8 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Planctomycetaceae
           RepID=A3ZTI8_9PLAN
          Length = 167

 Score =  110 bits (275), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 43/142 (30%), Positives = 63/142 (44%), Gaps = 26/142 (18%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           MS  + +   F A HRL     G KC   HGH+++    +T +     G +IDFA+LKA 
Sbjct: 9   MSLVIMRRIKFCAGHRL--YKHGGKCEFFHGHNYVADFYVTADEVDDVGRVIDFADLKAK 66

Query: 62  FK-PTYERLDHHYL------NDIPGLE------------NPTSEVLAKWIWDQVKPVV-- 100
           FK    E  DH +L      N I  ++            NPT+E +A+++ D V P +  
Sbjct: 67  FKGWLDEHWDHGFLLSEQDENGINAIKQVVPCKYFVMPYNPTAENMARYLLDYVCPELLD 126

Query: 101 ---PLLSAVMVKETCTAGCIYR 119
                   V++ ET  A    R
Sbjct: 127 QSNVRPVKVVIWETEEAFAEAR 148


>UniRef50_D1JB18 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=uncultured
           archaeon RepID=D1JB18_9ARCH
          Length = 120

 Score =  109 bits (273), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 34/124 (27%), Positives = 56/124 (45%), Gaps = 10/124 (8%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             L     F AAH LP      KC  LHGH++ V + + GE    T  + DF+E+KA  +
Sbjct: 1   MKLGVSTDFSAAHSLPRHT--GKCKNLHGHTYRVDIVVEGEKKKDTECVADFSEVKALVE 58

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP------LLSAVMVKETCTAGCI 117
              + +DH +LN+I     PTSE +A ++  + +           L ++ + E      +
Sbjct: 59  EVLDLVDHKHLNEIIAY--PTSENIALFLRAEFEKKFKDSNFGVTLHSIKIWEGKDKWVM 116

Query: 118 YRGE 121
              +
Sbjct: 117 VEAD 120


>UniRef50_C5RIU8 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Clostridium
           cellulovorans 743B RepID=C5RIU8_CLOCL
          Length = 145

 Score =  109 bits (272), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 33/139 (23%), Positives = 54/139 (38%), Gaps = 25/139 (17%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAELK 59
             L  + + ++AH L       KC  +HGH + V  EI  +         G I+DF   K
Sbjct: 5   YKLVSEHSMDSAHFLKDYD--GKCSNIHGHRWRVVAEIFSDQLINEGAEKGMIVDFGIFK 62

Query: 60  AAFKPTYERLDHHYLNDIPGLE-------------------NPTSEVLAKWIWDQVKPVV 100
              +   +  DH  + +   L+                    PT+E LAK+ ++Q+K   
Sbjct: 63  NDIRELVDFYDHCLIVEKGSLKTELFQMLTTEGFRVEEVSFRPTAENLAKFFFEQLKKKG 122

Query: 101 PLLSAVMVKETCTAGCIYR 119
             + +V+V ET      Y 
Sbjct: 123 HNMKSVVVYETPNNAATYE 141


>UniRef50_Q604L2 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Methylococcus
           capsulatus RepID=Q604L2_METCA
          Length = 137

 Score =  108 bits (270), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 38/135 (28%), Positives = 60/135 (44%), Gaps = 19/135 (14%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             ++ K+  F   HRL H     KC  LHGHS    + ++       G + DFA++ AA 
Sbjct: 1   MYSVTKEIFFCYGHRLMHHS--GKCRHLHGHSVRAAITVSASDLNFQGMVCDFADISAAA 58

Query: 63  KPTYE-RLDHHYL--NDIPGL--------------ENPTSEVLAKWIWDQVKPVVPLLSA 105
           +   +  LDH+ L   D P L              ++PT+E LA+ I+  ++     +  
Sbjct: 59  RDFIDTHLDHNLLLHRDDPLLPLLQQAGERVLALEQHPTAEALAEMIYRDLRRKGFAVQN 118

Query: 106 VMVKETCTAGCIYRG 120
           V + ET +A   YR 
Sbjct: 119 VTLWETSSACASYRE 133


>UniRef50_Q2PY17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Bacteria
           RepID=Q2PY17_9BACT
          Length = 137

 Score =  108 bits (270), Expect = 7e-23,   Method: Composition-based stats.
 Identities = 35/137 (25%), Positives = 55/137 (40%), Gaps = 18/137 (13%)

Query: 3   STTLFKDFTFEAAHRLPHVPE--------GHKCGR--LHGHSFMVRLEITGEVDPHTGWI 52
              + +   F AAHRL +              C     HGH+F + + + GEV+  TG++
Sbjct: 1   MIYIQRRAIFSAAHRLANPSWSDEKNQAVFGHCANEYSHGHNFQLIVTVKGEVNTDTGFV 60

Query: 53  IDFAELKAAFK-PTYERLDHHYLNDIPGLEN---PTSEVLAKWIWDQ----VKPVVPLLS 104
           ++  +LKA       + +DH  LN          P++E LA   W Q    +      L 
Sbjct: 61  MNMVDLKAIMDSEIIQHVDHRNLNHDVPFMQGIMPSTENLAMIFWQQIEGPIAKHGAALH 120

Query: 105 AVMVKETCTAGCIYRGE 121
            + + ET      Y GE
Sbjct: 121 CIRIVETENNMVEYYGE 137


>UniRef50_Q04S36 6-pyruvoyl-tetrahydropterin synthase n=6 Tax=Leptospira
           RepID=Q04S36_LEPBJ
          Length = 136

 Score =  107 bits (269), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 29/124 (23%), Positives = 52/124 (41%), Gaps = 7/124 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAA 61
              +  +  FE++H L           +HGHS+ V L ++G  +    G   DF   K  
Sbjct: 8   RFYIRIEERFESSHFLYKYFPDGSDEPIHGHSWKVELYLSGRKNIGEDGISFDFLTSKQR 67

Query: 62  FKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKP----VVPLLSAVMVKETCTAG 115
            K    +LDH  +N++   +  NPTSE +A+W +  +K         +  +++ E     
Sbjct: 68  LKELVGKLDHILINELEEFKKINPTSENIARWFYHYLKESVHSAGGRVDKIVIHEGPENL 127

Query: 116 CIYR 119
             + 
Sbjct: 128 AFFE 131


>UniRef50_Q1NNT9 Putative uncharacterized protein n=2 Tax=delta proteobacterium
           MLMS-1 RepID=Q1NNT9_9DELT
          Length = 154

 Score =  107 bits (268), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 31/124 (25%), Positives = 50/124 (40%), Gaps = 9/124 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             TL  + +F A HRL       +    H H + + + + G      G+++D  EL    
Sbjct: 27  MYTLGVNRSFSARHRLIGGDW-GEESITHAHCYRLEVALDGPELNEHGFLVDIVELAGNL 85

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSA-----VMVKETCTAG 115
               E  +   LND+P     NP+ E LA+ IW ++   +P         V V E   A 
Sbjct: 86  DLVQEAYEDRILNDLPEFAGLNPSIENLARLIWQRLS-QLPASDKLLSMSVTVWEDDQAW 144

Query: 116 CIYR 119
             ++
Sbjct: 145 ASFQ 148


>UniRef50_Q1IPJ0 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Candidatus Koribacter
           versatilis Ellin345 RepID=Q1IPJ0_ACIBL
          Length = 135

 Score =  107 bits (267), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 35/131 (26%), Positives = 58/131 (44%), Gaps = 15/131 (11%)

Query: 2   MSTTLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M   L + + F A+HRL         +     KC     HGH++ + + + G+V P TG 
Sbjct: 1   MKAHLTRRYWFVASHRLHTPRLSEAENREVYGKCNNPFGHGHNYALEVTVGGQVAPDTGM 60

Query: 52  IIDFAELKAAF-KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPL--LSAV 106
           + + A++     K   ER DH  LN +   +   PT+E L   I++ +K  +    L  V
Sbjct: 61  VYNLADVDRVVRKHILERYDHQNLNCLKEFQELVPTTENLCLAIFEILKRNLAEIHLDKV 120

Query: 107 MVKETCTAGCI 117
            ++ET      
Sbjct: 121 RLEETSQNSFE 131


>UniRef50_D2ML00 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
           Poribacteria sp. WGA-A3 RepID=D2ML00_9BACT
          Length = 143

 Score =  107 bits (267), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 41/132 (31%), Positives = 59/132 (44%), Gaps = 15/132 (11%)

Query: 3   STTLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWI 52
              + + + F AAHRL         +     KC     HGH + V + +TGE+DP TG +
Sbjct: 4   KICVTRQYRFCAAHRLHTDALSDDVNRKVYDKCNNPNGHGHDYTVFVTVTGELDPQTGEV 63

Query: 53  IDFAELKAAF-KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVM 107
            D   L     +   ER DH +LN  P  +    T E L K+IWD++   +P   L  + 
Sbjct: 64  TDIHALDGLVNRKIVERFDHRHLNHDPAFQQLVTTGENLVKFIWDELVDDIPGGRLEKIG 123

Query: 108 VKETCTAGCIYR 119
           + ET      YR
Sbjct: 124 LIETRDNYFEYR 135


>UniRef50_A8Y1U6 C. briggsae CBR-PTPS-1 protein n=2 Tax=Caenorhabditis briggsae
           RepID=A8Y1U6_CAEBR
          Length = 132

 Score =  106 bits (265), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 36/125 (28%), Positives = 62/125 (49%), Gaps = 16/125 (12%)

Query: 12  FEAAHRL--------PHVPEGHKCGR--LHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           F AAHRL         +     KC     HGH+++ ++++ GEVDP +G + D A+LK  
Sbjct: 7   FSAAHRLNSENLSVAENKETFGKCNNDNGHGHNYVWKVKLRGEVDPVSGMVYDLAKLKKE 66

Query: 62  FKPTYERLDHHYLN-DIPGLENP--TSEVLAKWIWDQVKPVVPL---LSAVMVKETCTAG 115
                + +DH  L+ D+   +    TSE +A +++ ++K V+     L    ++ET    
Sbjct: 67  MNLVLDTVDHRNLDKDVEFFKTTVSTSENVAIYMYQKLKSVMSNPSVLYKCTIEETPKNV 126

Query: 116 CIYRG 120
             Y+G
Sbjct: 127 FTYKG 131


>UniRef50_Q7UGM2 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Rhodopirellula
           baltica RepID=Q7UGM2_RHOBA
          Length = 137

 Score =  105 bits (264), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 26/138 (18%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           + FTF + HRL       KC  LHGH++++ + +TGE     G I+DF +LK   K   +
Sbjct: 2   RRFTFCSGHRLVGHE--GKCQNLHGHNYVLEVYVTGEEQDAIGRILDFKQLKTRCKNWID 59

Query: 68  R-LDHHYL------NDIPGLE------------NPTSEVLAKWIWDQVKPVV-----PLL 103
              DH ++      N +  +             NPT+E +AK   +++ P +        
Sbjct: 60  ENWDHTFVLWKKDQNGLDAIRSSEPHRIYELESNPTAENMAKHFLEKICPSILGDSGATA 119

Query: 104 SAVMVKETCTAGCIYRGE 121
             V + E+         +
Sbjct: 120 YKVRLWESEETYAEVELD 137


>UniRef50_A7BS03 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Beggiatoa sp. PS
           RepID=A7BS03_9GAMM
          Length = 148

 Score =  105 bits (263), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 41/140 (29%), Positives = 65/140 (46%), Gaps = 23/140 (16%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    +     +E AHRL H     KC  +HGHS    +E+        G+++DFA++K 
Sbjct: 1   MNMYKIIVKIKYEYAHRLLHHT--GKCRHVHGHSGEAIIELASNTLNDNGFVMDFADVKT 58

Query: 61  AFKPTYER-LDHHYL-NDIPGL---------------ENPTSEVLAKWIWDQV----KPV 99
             K    +  DH YL N+   L               E PT+EV+A+ +++Q     +P 
Sbjct: 59  PLKKWINQFWDHAYLANESDPLLPAFKSENMNIYTFPEEPTAEVMARHLFEQAAILERPP 118

Query: 100 VPLLSAVMVKETCTAGCIYR 119
             +L+ V ++ETCT    Y+
Sbjct: 119 GVILTRVTIRETCTGQASYQ 138


>UniRef50_D0MDN2 Putative uncharacterized protein n=1 Tax=Rhodothermus marinus DSM
           4252 RepID=D0MDN2_RHOM4
          Length = 156

 Score =  104 bits (261), Expect = 7e-22,   Method: Composition-based stats.
 Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 30/140 (21%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K F FEAAHRLP  P    C  LHGHS+ + + + G      G ++DF +LK   +
Sbjct: 1   MKVAKRFRFEAAHRLPWHP--GACRHLHGHSYRLVVGLEGNP-DARGILVDFQDLKRLVQ 57

Query: 64  PTYERLDHHYLND------------------IPGLENPTSEVLAKWIW--------DQVK 97
           P  +  DH  L                    +   ++ T+E L  ++         D ++
Sbjct: 58  PLIDTWDHATLVASDDTALQDALDALGSRYVVLPFDS-TAENLCAYVADYLIREAGDWLR 116

Query: 98  PVVPLLSAVMVKETCTAGCI 117
                   V + ET T+   
Sbjct: 117 ARGVRRLWVRLAETETSFAE 136


>UniRef50_A0L5B3 Putative uncharacterized protein n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L5B3_MAGSM
          Length = 142

 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 40/131 (30%), Positives = 59/131 (45%), Gaps = 19/131 (14%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG------EVDPHTGWIIDFAE 57
             + + F FE+AHRLP+     KC RLHGHS+ + +  +G      E DP +G++ DF  
Sbjct: 1   MKIARMFKFESAHRLPYHD--GKCHRLHGHSYRLEMIFSGTVRQPDEKDPQSGFVADFGI 58

Query: 58  LKAAFKP--TYERLDHHYLND-IPGLENPTSEVLAKWIWDQVKPVVPL--------LSAV 106
           +    K       LDH  LN  +PG+   ++E L+ WI       +          +  V
Sbjct: 59  VNDLVKEQLIDRYLDHRDLNASVPGIPYTSAEYLSAWIVGWCMRELEGHPQLGDLKIERV 118

Query: 107 MVKETCTAGCI 117
            V ET  A   
Sbjct: 119 RVWETINAWAE 129


>UniRef50_C1AB96 6-pyruvoyl tetrahydropterin synthase family protein n=1
           Tax=Gemmatimonas aurantiaca T-27 RepID=C1AB96_GEMAT
          Length = 151

 Score =  104 bits (260), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 37/139 (26%), Positives = 59/139 (42%), Gaps = 20/139 (14%)

Query: 1   MMSTTLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTG 50
           M  T+L +   F AAHR          +      C     HGH+++  + + G VD  TG
Sbjct: 10  MPRTSLTRRVLFAAAHRYRRPDWSDQENADVFGACAHPNYHGHTYLCDVTVAGPVDEETG 69

Query: 51  WIIDFAELKAAF-KPTYERLDHHYLN-DIPGLEN----PTSEVLAKWIWDQVKPVV---- 100
           +++D   L     +   ER DH  +N D+P        PT E LA++I ++V+  +    
Sbjct: 70  FVVDLGFLDRVLQREVRERFDHRNINLDVPEFAEGRLIPTGENLARFICERVQAALAHTT 129

Query: 101 PLLSAVMVKETCTAGCIYR 119
             +  V + E  T    Y 
Sbjct: 130 ARVVRVHLAEDTTLSSTYE 148


>UniRef50_Q0AAF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Proteobacteria
           RepID=Q0AAF2_ALHEH
          Length = 175

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 40/176 (22%), Positives = 58/176 (32%), Gaps = 59/176 (33%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFA 56
           M S T+ +    +AAHR+P    G +C  LHGH ++V                G ++DF 
Sbjct: 1   MSSFTVTRRVEIDAAHRIP--DHGSRCRHLHGHRYVVEAACGNPSLQEAGEERGMVLDFG 58

Query: 57  ELKAAFKPTYE-RLDHHYL---NDIPGLE------------------------------- 81
            LK       +   DH  L   +D   L                                
Sbjct: 59  FLKEEMLAVIDAPCDHGLLLSVDDHVMLALLAGGSDRPEAWLEGLRERVAGQGYAEGRDP 118

Query: 82  -----------NPTSEVLAKWIWDQVKPVV-------PLLSAVMVKETCTAGCIYR 119
                       PT+EVLA+  ++++ P V         L AV V ET      Y+
Sbjct: 119 ALGGKLYLVPGPPTAEVLARHWYERLAPRVHARSRGNAALLAVTVWETPNCWARYQ 174


>UniRef50_Q675S7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Oikopleura dioica
           RepID=Q675S7_OIKDI
          Length = 136

 Score =  104 bits (259), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 33/136 (24%), Positives = 60/136 (44%), Gaps = 18/136 (13%)

Query: 2   MSTTLFKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGW 51
           M  ++ +       HRL         +     KC     HGH++ ++  I GE+   TG 
Sbjct: 1   MKCSIIRTEKICTGHRLHSPYLTDEENRKVYGKCNHPNGHGHNYTIQAVIEGEIIKETGM 60

Query: 52  IIDFAELKAAFKPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL----LS 104
           +++  +LK A      +LDH  ++ D+   +N   T+E +A+WI+ Q+   +P     L 
Sbjct: 61  VMNLVDLKVAMWKVLSQLDHRNVDKDVEYFKNVPSTAENVAQWIFIQLSQELPTGSYHLK 120

Query: 105 AVMVKETCTAGCI-YR 119
            +++ ET       Y 
Sbjct: 121 KIILDETDKNRVEIYE 136


>UniRef50_A4CIF9 6-pyruvoyl tetrahydropterin synthase n=19 Tax=Bacteroidetes
           RepID=A4CIF9_9FLAO
          Length = 151

 Score =  103 bits (258), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 34/145 (23%), Positives = 55/145 (37%), Gaps = 30/145 (20%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT-----GWIIDF 55
           M    + K+FTFE  H L       KC  +HGHS+ + + + G           G ++DF
Sbjct: 1   MARVRITKEFTFETGHALYGYD--GKCRNVHGHSYHLSVTVIGTPIAEDGAVKLGMVMDF 58

Query: 56  AELKAAFK-PTYERLDHHYL-------------------NDIPGLENPTSEVLAKWIWDQ 95
            +LK   +    +R DH  +                     I     PTSE +      +
Sbjct: 59  GDLKKVVREEVVDRFDHATIFNRNTPHVELARTLEREGHRVILADYQPTSENMVVDFAHR 118

Query: 96  VKPVVP---LLSAVMVKETCTAGCI 117
           +   +P    L ++ ++ET TA   
Sbjct: 119 ISKRLPEHIRLHSLRLRETGTAYAE 143


>UniRef50_Q1RHI6 6-carboxy-5,6,7,8-tetrahydropterin synthase n=4 Tax=Rickettsia
           RepID=QUED_RICBR
          Length = 138

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 28/139 (20%), Positives = 54/139 (38%), Gaps = 26/139 (18%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
                +   F+A HR+      +KC  LHGH +++ + I  +     G ++DF  +K   
Sbjct: 1   MIKCTRRIEFDAGHRIIGHQ--NKCQYLHGHRYVLEITIAAKNTDELGMVVDFGLIKDLA 58

Query: 63  K-PTYERLDHHYL-----------------NDIPGLE-NPTSEVLAKWIWDQVKPVVPL- 102
           K    E  DH  +                   +  L+ NPT+E +A  + +++ P +   
Sbjct: 59  KGWVDENFDHSLILHQGDKEIGQKIESHTGQKVYYLKNNPTAENIALHLKNEIFPKLFES 118

Query: 103 ----LSAVMVKETCTAGCI 117
               ++ + + ET      
Sbjct: 119 QKFFVTNIKLFETPNCFVE 137


>UniRef50_UPI0001C418E1 queuosine biosynthesis protein QueD n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C418E1
          Length = 119

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 35/118 (29%), Positives = 55/118 (46%), Gaps = 5/118 (4%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGE--VDPHTGWIIDFAELKA 60
             TL  +      H+L    +G KC + HGH + V L +        +   I+D  +++A
Sbjct: 1   MLTLVSEHRIYGCHKLK--DQGGKCTQWHGHQYRVILTLQAPYKDLDYRNMIMDTYDIEA 58

Query: 61  AFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
            F      +DH  LN+    ENPT E ++K+ +D +K  +  L +V V ET   G  Y
Sbjct: 59  IFNEFIG-VDHLNLNEFMDSENPTMEEMSKFFYDGLKDKIECLVSVGVYETPETGVTY 115


>UniRef50_Q3ATI1 6-pyruvoyl tetrahydrobiopterin synthase, putative n=6
           Tax=Chlorobium/Pelodictyon group RepID=Q3ATI1_CHLCH
          Length = 142

 Score =  103 bits (257), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 37/144 (25%), Positives = 59/144 (40%), Gaps = 28/144 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-----EVDPHTGWIIDFAEL 58
             + +    +  H LP+      C +LHGH  +V   + G     E     G ++DF  L
Sbjct: 1   MRISRKIEIDYGHTLPNSFSF--CNQLHGHRGVVVATVEGNIISQEQHSQQGMVMDFKFL 58

Query: 59  KAA-FKPTYERLDHHYL---NDIPGLEN--------------PTSEVLAKWIWDQVKPVV 100
           K    +  +++LDH +    +D   LE               PT+E LA+W + Q++P +
Sbjct: 59  KDIMVEQIHDKLDHGFAVWKHDTEDLEFITRRNTRVLITDEPPTAECLARWAFHQMQPHL 118

Query: 101 P---LLSAVMVKETCTAGCIYRGE 121
           P    L  +   ET      Y GE
Sbjct: 119 PAGVTLQRIRWYETPNNWADYEGE 142


>UniRef50_B2UBF2 Queuosine biosynthesis protein QueD n=85 Tax=cellular organisms
           RepID=B2UBF2_RALPJ
          Length = 158

 Score =  102 bits (256), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 39/145 (26%), Positives = 62/145 (42%), Gaps = 34/145 (23%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-----PHTGWIIDFAEL 58
            ++ +   F+A HR+P      +C  LHGH + + L +TGEV         G I+DF ++
Sbjct: 5   VSITRRLEFDAGHRIPGHA--GQCRNLHGHRYQLELTLTGEVLHNDKAADDGMILDFGDV 62

Query: 59  KAAF-KPTYERLDHH------------YLNDIPG-------LENPTSEVLAKWIWDQVKP 98
           K    K   +  DH             +LND+ G        + PT E LA+  +D ++P
Sbjct: 63  KQLANKHLVDLWDHAFLVYRGDTKLVEFLNDMEGGHKTVVLNDVPTVENLAQVAFDILEP 122

Query: 99  VVP-------LLSAVMVKETCTAGC 116
           V          LS +++ ET     
Sbjct: 123 VFRNAFGHHLRLSKLVLYETPNCWA 147


>UniRef50_Q0KAE6 6-Pyruvoyl tetrahydrobiopterin synthase protein n=5
           Tax=Burkholderiaceae RepID=Q0KAE6_RALEH
          Length = 158

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 34/149 (22%), Positives = 61/149 (40%), Gaps = 33/149 (22%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-----PHTGWIIDFAE 57
             ++ +   F++ HR+P+     +C  +HGH + + L ++GEV         G I+DF +
Sbjct: 4   QVSITRRLEFDSGHRIPN--HCGQCRNIHGHRYRLDLTLSGEVLHREGASDDGMILDFGD 61

Query: 58  LKAAFKP-TYERLDHHY---------LNDIPGLEN---------PTSEVLAKWIWDQVKP 98
           +KA        + DH +         LN +  +E          PT E LA+  +D + P
Sbjct: 62  IKALANEHLVNKWDHAFLIYRGDTALLNFLQSMEGHKTVVLDAIPTVENLAQVAFDILAP 121

Query: 99  VVP-------LLSAVMVKETCTAGCIYRG 120
           V          L+ +++ ET         
Sbjct: 122 VFKDCFGHHLQLTRLVLFETPNCWAEVSA 150


>UniRef50_B3T9P1 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=uncultured
           marine crenarchaeote HF4000_APKG7F19 RepID=B3T9P1_9ARCH
          Length = 120

 Score =  102 bits (255), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 38/120 (31%), Positives = 59/120 (49%), Gaps = 10/120 (8%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP----HTGWIIDFAE 57
           M T +  +F  + AH L   P   KCG+ HGH+  + +E  GE+          II+F E
Sbjct: 1   MQTKIGVEFEIDFAHTLKGHP---KCGKPHGHTARIIVEAAGELKNGSTYKDNMIIEFDE 57

Query: 58  LKAAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           +K     T ++LDH  L+ +   + PTSE +A WI++ +K  +P +  V   E     C 
Sbjct: 58  MKKICWQTLQQLDHTNLDSM--FDFPTSENIAMWIFEHLKDKIP-IYGVKFFEGSNKYCE 114


>UniRef50_B3QUQ1 Putative uncharacterized protein n=1 Tax=Chloroherpeton thalassium
           ATCC 35110 RepID=B3QUQ1_CHLT3
          Length = 153

 Score =  102 bits (255), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 21/137 (15%)

Query: 6   LFKDFTFEAAHRLPHVPE--------GHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDF 55
           + +   F AAHRL +             +C  +  HGH++ + + + G VD  TG++ D 
Sbjct: 17  VTRKVHFSAAHRLFNPEFSDAENELIYDRCNNIYGHGHNYELEVTLKGPVDKATGYVFDL 76

Query: 56  AELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKPVVPL-------LS 104
            +L     +    ++DH +LN D+  L++  P++EVL+   W+ ++  +         L 
Sbjct: 77  KKLDKILSEEILSKVDHKHLNFDVEMLKDMIPSAEVLSIVFWNAIQNRLSELGYTQVALY 136

Query: 105 AVMVKETCTAGCIYRGE 121
            V + E+      YRG+
Sbjct: 137 EVKLFESERNFVRYRGD 153


>UniRef50_Q3B2Y4 6-pyruvoyl tetrahydrobiopterin synthase, putative n=6
           Tax=Chlorobiaceae RepID=Q3B2Y4_PELLD
          Length = 162

 Score =  102 bits (254), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 38/144 (26%), Positives = 58/144 (40%), Gaps = 28/144 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEV-----DPHTGWIIDFAEL 58
             + +    +  H LP+      C +LHGH  +V   + G V     D   G ++DF  L
Sbjct: 18  MQISRKIEIDYGHTLPNHFSF--CNQLHGHRGVVVATVEGPVIERSGDSEEGMVMDFRFL 75

Query: 59  KAA-FKPTYERLDHHYL---NDIPGLEN--------------PTSEVLAKWIWDQVKPVV 100
           K    +  + RLDH +     D   LE               PT+E LAKW +++++  +
Sbjct: 76  KEIMVEHIHNRLDHGFAVWREDHEDLEFILKRNTRVLVTDDPPTAEYLAKWAFNEIRTHL 135

Query: 101 PL---LSAVMVKETCTAGCIYRGE 121
           P    L  V   ET      Y G+
Sbjct: 136 PEGISLHNVRWYETPNNWADYDGQ 159


>UniRef50_Q92J44 6-carboxy-5,6,7,8-tetrahydropterin synthase n=11 Tax=Rickettsia
           RepID=QUED_RICCN
          Length = 138

 Score =  102 bits (254), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 28/139 (20%), Positives = 54/139 (38%), Gaps = 26/139 (18%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
                +   F+A HR+  +   +KC  LHGH +++ + I        G +IDF  +K   
Sbjct: 1   MIKCTRRIEFDAGHRI--IEHQNKCQFLHGHRYVLEIAIAANKTDKLGMVIDFGLIKDLA 58

Query: 63  KPTYER-LDHHYLNDIPGLE------------------NPTSEVLAKWIWDQVKPVVPL- 102
           K   +   DH  +      E                  NPT+E +A  + +++ P + + 
Sbjct: 59  KKWIDENFDHSLILHQDDKEMGQQIENCTGQKIYYMQNNPTAENIATHLKNEIFPKLFVS 118

Query: 103 ----LSAVMVKETCTAGCI 117
               ++++ + ET      
Sbjct: 119 QNFFVTSLKLYETPNCFVE 137


>UniRef50_A3VUJ4 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Parvularcula
           bermudensis HTCC2503 RepID=A3VUJ4_9PROT
          Length = 136

 Score =  101 bits (253), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 44/109 (40%), Positives = 55/109 (50%), Gaps = 3/109 (2%)

Query: 3   STTLFKDFTFEAAHRL---PHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
                  F FEAAH L         H    +HGHSF V + +        GWI+DFAELK
Sbjct: 15  MYYQSYSFFFEAAHELGEMKPEDSAHLYAEIHGHSFEVTVTLAAATIEPEGWIMDFAELK 74

Query: 60  AAFKPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMV 108
           AA +     LDH  LN I GL  PT E LA +I +++ P +P LS V +
Sbjct: 75  AACETVRGLLDHRLLNRIEGLSRPTLERLADFIIERLSPDLPALSEVEI 123


>UniRef50_C7MN71 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Coriobacteriaceae
           RepID=C7MN71_CRYCD
          Length = 146

 Score =  101 bits (253), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 26/140 (18%), Positives = 44/140 (31%), Gaps = 27/140 (19%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG----EVDPHTGWIIDFAEL 58
              L  +  F+ AH L       KC  LHGH + V   +              ++DF+  
Sbjct: 1   MYGLKTESYFDGAHFLAEY--HGKCENLHGHRWRVVAILGSACLMPSGDERDMVMDFSSF 58

Query: 59  KAAFKPTYERLDHHYLND--------------------IPGLENPTSEVLAKWIWDQVKP 98
           K   +      DH ++ +                    +      T+E  A+  + ++  
Sbjct: 59  KQTLRDLTAAFDHTFIVEEGTLAPDTLDCLAREGFHLTMVPFR-TTAENFARHFFSKLDQ 117

Query: 99  VVPLLSAVMVKETCTAGCIY 118
               +  V V ET     IY
Sbjct: 118 AGFPVEQVEVYETPMNCAIY 137


>UniRef50_Q1IAJ5 Putative 6-pyruvoyl-tetrahydropterin synthase-like n=1
           Tax=Pseudomonas entomophila L48 RepID=Q1IAJ5_PSEE4
          Length = 175

 Score =  101 bits (252), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 35/166 (21%), Positives = 53/166 (31%), Gaps = 52/166 (31%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAEL 58
              + +    +A HR+     G KC  LHGH + V +  + +        TG ++DF+  
Sbjct: 1   MFKIDRKIEIDAGHRIR--SHGSKCRNLHGHRYSVHMTCSADELATHGSETGMVLDFSFA 58

Query: 59  KAAFKPTYERL-DHHYLNDIP------------------------GLEN----------- 82
           K A     + L DH  + D                           L N           
Sbjct: 59  KDAMVQCIDELCDHALIVDAEDEYLLQVLDIHGPARDVRTSGVALPLTNGEGMKIYLVPF 118

Query: 83  -PTSEVLAKWIWDQVKPVVPLL---------SAVMVKETCTAGCIY 118
            PT+E LAK  ++ +   V  L           + V ET      Y
Sbjct: 119 SPTAEALAKHWYELLSDKVATLGHGAAQVRVDTIRVYETPNCWAEY 164


>UniRef50_C7IE00 Putative uncharacterized protein n=1 Tax=Clostridium papyrosolvens
           DSM 2782 RepID=C7IE00_9CLOT
          Length = 154

 Score =  100 bits (250), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 32/151 (21%), Positives = 64/151 (42%), Gaps = 36/151 (23%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-------EVDPHTGWII 53
           M   ++ K+F+++ AH L +      C  LHGH++ ++++I+        +     G ++
Sbjct: 1   MGKISITKEFSWDMAHMLSN--HRGLCSNLHGHTYRMQVQISRKDKGVLEDTLHSDGMVM 58

Query: 54  DFAELKAAF-KPTYERLDHHYL-----NDIPGLE-----------------NPTSEVLAK 90
           DF++LKA   +   E LDH ++     ND    +                  PT+E +A 
Sbjct: 59  DFSDLKAIVQRKIIEPLDHAFMFWCDTNDSVERQIAELLKSSGKKVASVKYRPTAEEMAA 118

Query: 91  WIWDQVKPVVPL----LSAVMVKETCTAGCI 117
             +D +   +      +  + + ET T+   
Sbjct: 119 SFFDVLTQELADSDIVVDKIKIWETTTSFAE 149


>UniRef50_A6GQ16 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Limnobacter sp. MED105 RepID=A6GQ16_9BURK
          Length = 116

 Score =  100 bits (249), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 44/119 (36%), Positives = 62/119 (52%), Gaps = 12/119 (10%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             +FK FTF+ AH+LP  P       LHGHS+   +   G      G+++  + L     
Sbjct: 1   MKVFKQFTFDVAHQLPDWPG------LHGHSYTAEVWFEGPATD--GYVVPESLLTQHVG 52

Query: 64  PTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKE-TCTAGCIYRGE 121
             ++RLDH YLN+   L  PTSE +A+WIWDQ++PV P L  V V   +   G  +  E
Sbjct: 53  AVHKRLDHSYLNEFIEL--PTSENIARWIWDQLRPVGP-LIKVKVFRGSIGFGVEFDLE 108


>UniRef50_D1R7R7 Putative uncharacterized protein n=2 Tax=Parachlamydia
           acanthamoebae str. Hall's coccus RepID=D1R7R7_9CHLA
          Length = 143

 Score = 99.8 bits (248), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 35/142 (24%), Positives = 53/142 (37%), Gaps = 27/142 (19%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M +    +   F A HR+ +    +KC   HGH++ V L          G +IDF+ LK 
Sbjct: 1   MNTVKCTRKIHFCAGHRVMNHE--NKCATAHGHNYYVHLTAEAPQLDSLGRVIDFSVLKE 58

Query: 61  AF-KPTYERLDHHYLNDIPGLE-------------------NPTSEVLAKWIWDQVKPVV 100
                  E  DH +L      E                   NPT+E +A ++  +V P V
Sbjct: 59  KVGGWIDEHWDHTFLVCEHDKELIQALRSLPRKKEPFICPFNPTAEEIAIYLLREVSPKV 118

Query: 101 PL-----LSAVMVKETCTAGCI 117
                  ++ V+V ET      
Sbjct: 119 LAGSNVMITKVVVHETDNCYAE 140


>UniRef50_A1ZSU4 6-pyruvoyl tetrahydrobiopterin synthase n=7 Tax=Sphingobacteriales
           RepID=A1ZSU4_9SPHI
          Length = 158

 Score = 99.0 bits (246), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 32/139 (23%), Positives = 55/139 (39%), Gaps = 20/139 (14%)

Query: 3   STTLFKDFTFEAAHRLPHVPE--------GHKC--GRLHGHSFMVRLEITGEVDPHTGWI 52
              + +  TF A+H+L +              C     HGH+F + + + G  D  TG +
Sbjct: 1   MVYICRRETFNASHKLYNPNWSKEQNEALFGVCANQNWHGHNFELVVTVKGMPDLETGMV 60

Query: 53  IDFAELKAAF-KPTYERLDHHYLN---DIPGLENPTSEVLAKWIWDQVKPVVP------L 102
           ID+  L     +   E++ +  LN   D    + P+ E+L    W ++ P +        
Sbjct: 61  IDYKVLSKIVRREIIEKVHYKNLNLDVDFLAGKMPSCEILIIEFWKRLAPAIQQESPRTT 120

Query: 103 LSAVMVKETCTAGCIYRGE 121
           L  + + ET      Y GE
Sbjct: 121 LHHLKLVETKNNSVEYMGE 139


>UniRef50_A9GTQ5 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9GTQ5_SORC5
          Length = 136

 Score = 98.6 bits (245), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 26/124 (20%), Positives = 55/124 (44%), Gaps = 7/124 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T+        AH L  V +     RLHG ++ V +E+  E     G +++ + L+ + 
Sbjct: 1   MYTVGVRDHIMVAHSLKGV-QFGPAQRLHGATYTVSVEVEREELSPLGQVVETSALRDSL 59

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLS----AVMVKETCTAGC 116
           +     +D+  L++ P  E    T E++A++I  ++   +P+ +     + + E+     
Sbjct: 60  RAVLAEIDYRNLDEHPAFEGKRSTPELIARYIHRELGRKLPVSAGSALTITLNESPLVWV 119

Query: 117 IYRG 120
            YR 
Sbjct: 120 RYRA 123


>UniRef50_A2STX2 6-pyruvoyl-tetrahydropterin synthase-like protein n=5
           Tax=Methanomicrobiales RepID=A2STX2_METLZ
          Length = 135

 Score = 98.3 bits (244), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 35/141 (24%), Positives = 60/141 (42%), Gaps = 27/141 (19%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M T ++K+  F+A+HRL H     KC RLHGH + V + + G  D  +  ++D+  +K  
Sbjct: 1   MVTRIYKETHFDASHRLMHYE--GKCSRLHGHRWSVEVWMDGTPDEKSRILLDYNIIKN- 57

Query: 62  FKPTYERLDHH-YLNDIPGL--------------ENPTSEVLAKWIWDQVK------PVV 100
                   DH   LN    +               +PTSE+LA+ I +++        + 
Sbjct: 58  ---IINVYDHQVVLNKDDPMVEALSRFQTPVLTNGDPTSELLAEDIRERLNTFCREHDLS 114

Query: 101 PLLSAVMVKETCTAGCIYRGE 121
             ++ + V E+         E
Sbjct: 115 ARVAKLRVWESEGCYAEVFAE 135


>UniRef50_B2UPS6 6-pyruvoyl-tetrahydropterin synthase-like protein n=2
           Tax=Verrucomicrobia RepID=B2UPS6_AKKM8
          Length = 150

 Score = 97.9 bits (243), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 50/150 (33%), Gaps = 35/150 (23%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + K    E  H L   P    C   HGH+  V +    E       ++DF  +K  
Sbjct: 1   MVYRICKSIELENGHLLSKHP--GNCKFPHGHTRSVEMVFRAETLDANDMVLDFKAVKQM 58

Query: 62  FKPTYERLDHH----------------YLNDIPGL--ENPTSEVLAKWIWDQVKPVVP-- 101
                ++ DH                 Y   I     E+PTSEV+A+ I++  +  +   
Sbjct: 59  MGDFLQQFDHSLCVNTEDPNYAAFVAAYGERIIPFDREDPTSEVMARVIFNVARHALEKA 118

Query: 102 -------------LLSAVMVKETCTAGCIY 118
                         L  V V ET ++   Y
Sbjct: 119 RENPGEYPVRACVELERVRVWETSSSWAEY 148


>UniRef50_C6MFP0 Queuosine biosynthesis protein QueD n=1 Tax=Nitrosomonas sp. AL212
           RepID=C6MFP0_9PROT
          Length = 163

 Score = 97.9 bits (243), Expect = 9e-20,   Method: Composition-based stats.
 Identities = 30/145 (20%), Positives = 52/145 (35%), Gaps = 33/145 (22%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH-----TGWIIDFAE 57
           S  + +   F+A HR+       +C  LHGH + + + ++G +         G ++DFA 
Sbjct: 14  SMLITRKLEFDAGHRI--STHNSQCRHLHGHRYCIEITLSGNIIADEGVAQQGMVMDFAA 71

Query: 58  LKAAFKP-TYERLDH------------HYLNDIPGLE------NPTSEVLAKWIWDQVKP 98
           +K   K    +  DH             +L  I   +       PT+E LA   ++ +  
Sbjct: 72  VKQIAKSTLVDYWDHAFLVYSGDKKVLQFLQSIEDHKTVVLDVQPTAENLALIAFNILDD 131

Query: 99  VVP-------LLSAVMVKETCTAGC 116
                      L  V + ET     
Sbjct: 132 AYQDSYGNHLQLEQVRLFETPNCWA 156


>UniRef50_A0JSM2 Putative uncharacterized protein n=7 Tax=Bacteria
           RepID=A0JSM2_ARTS2
          Length = 132

 Score = 97.5 bits (242), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 25/129 (19%), Positives = 45/129 (34%), Gaps = 11/129 (8%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             +L     F  AH LP          LHG +F+  +            ++D        
Sbjct: 1   MFSLTVRRHFMIAHSLPR-EAFGPAQGLHGATFVAEVTFRRRALNDDAIVLDIGAAGGLI 59

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLL--------SAVMVKETC 112
           +     L++  L++ P    +  T+E LA++I + V   V            AV ++E  
Sbjct: 60  EEVLAGLNYKNLDEHPDFAGKLSTTEALAQYIAEAVAAKVRGSLDGRELAGLAVTLRENP 119

Query: 113 TAGCIYRGE 121
            A   +  +
Sbjct: 120 DAWASFSLD 128


>UniRef50_UPI00016C4ECA 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C4ECA
          Length = 164

 Score = 97.1 bits (241), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 35/157 (22%), Positives = 59/157 (37%), Gaps = 42/157 (26%)

Query: 3   STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              + KD   F   H + +   GH+C RLHGH++   +E+ G + P   ++ DF  LK  
Sbjct: 7   KVRVTKDHLVFCCGHFISY--RGHQCERLHGHNYRCAVEVEGPLLPDDFYVFDFIALKKR 64

Query: 62  FKPTYERLDHHYLND--------------------------------IPGLENPTSEVLA 89
            K   + LDHH L                                  +  +EN T+E++A
Sbjct: 65  TKEITDELDHHMLLATNNPVISVAPTPQCVQVRYEDREWLFPRGDCILLPIENTTAELIA 124

Query: 90  KWIWDQVKPVV-------PLLSAVMVKETCTAGCIYR 119
           ++I  ++   +       P +  V V+E         
Sbjct: 125 RYIAGRLWESLKTNENFTPEVLRVEVEEAPGQSATVE 161


>UniRef50_C1VD01 PreQ(0) biosynthesis protein QueD n=1 Tax=Halogeometricum
           borinquense DSM 11551 RepID=C1VD01_9EURY
          Length = 160

 Score = 95.9 bits (238), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 35/132 (26%), Positives = 57/132 (43%), Gaps = 28/132 (21%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           +     A HRL H     KC R HGH++ + +E+TG++    GWI+D    K       +
Sbjct: 36  RPIRISAGHRLMHHD--GKCSRPHGHNYEISVEVTGQLTDE-GWIVD----KGEVTTVID 88

Query: 68  RLDHHYLND-----IPGLE-------------NPTSEVLAKWIWDQVKPVVPLLSA---V 106
             DH +L +     +   E              PT+EV+A  + D+++  +P   +   V
Sbjct: 89  EWDHRFLVETGDPLVSAFEASGDADSLVVLDAPPTAEVMAVLLEDKLRARLPDSVSDVAV 148

Query: 107 MVKETCTAGCIY 118
            V+ET      Y
Sbjct: 149 EVRETGELCASY 160


>UniRef50_B8HQA0 Putative uncharacterized protein n=1 Tax=Cyanothece sp. PCC 7425
           RepID=B8HQA0_CYAP4
          Length = 146

 Score = 95.9 bits (238), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 37/144 (25%), Positives = 58/144 (40%), Gaps = 28/144 (19%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L      EAAHR        KC  +HGHS+ V L +  E     G +I+F +LK A+
Sbjct: 1   MYRLEIRHNAEAAHRFFQADNSLKCRSIHGHSWSVILTLKAEKLDAQGMVIEFGQLKTAW 60

Query: 63  KPTYE-RLDHH-YLNDIPGL-----------------ENPTSEVLAKWIWDQVKPVVPLL 103
           +   +  LDH   L++   L                  +PT+E LA+ + +Q + V+  L
Sbjct: 61  RSWLDAHLDHTLMLHEQDPLVAVLQATDPQLRLFLLPLDPTTENLARVLAEQAERVLEQL 120

Query: 104 ---------SAVMVKETCTAGCIY 118
                      + ++ET      Y
Sbjct: 121 GYFPPTVQVERLRLEETSVNAAEY 144


>UniRef50_A1VXP3 6-pyruvoyl tetrahydrobiopterin synthase, homolog n=25
           Tax=Epsilonproteobacteria RepID=A1VXP3_CAMJJ
          Length = 193

 Score = 95.6 bits (237), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 28/148 (18%), Positives = 53/148 (35%), Gaps = 30/148 (20%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K F FE AH +           +HGHS+ V + +  +   + G + DF  LK   +
Sbjct: 1   MIIRKLFEFENAHIVRFCSSKRCKSSIHGHSYKVEVLLESKYLDNAGMVYDFGLLKTYIR 60

Query: 64  PTYERLDH----------HYLNDIPGLE--------NPTSEVLAKWIWDQVKPVVP---- 101
              +  DH           YL ++            N ++E   +  +  +  ++     
Sbjct: 61  QIIDSFDHAITLFKYDDAKYLEEMKKYSSRWICLPVNVSAENFCRVFFILIDALLKQTKM 120

Query: 102 -------LLSAVMVKETCTAGCI-YRGE 121
                   L +++V ET T     +R +
Sbjct: 121 INGEQGVTLQSIIVHETRTGYAQGFRED 148


>UniRef50_Q2RTB4 Putative uncharacterized protein n=1 Tax=Rhodospirillum rubrum ATCC
           11170 RepID=Q2RTB4_RHORT
          Length = 191

 Score = 94.0 bits (233), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 30/165 (18%), Positives = 50/165 (30%), Gaps = 52/165 (31%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD----PHTGWIIDFAEL 58
              + +    +A HR+     G KC  LHGH + + + +  +        +G + DF+ L
Sbjct: 1   MFEITRKIEIDAGHRIR--EHGSKCRNLHGHRYQIHVSVRSDQLVAGGSESGMVADFSFL 58

Query: 59  KAA-FKPTYERLDHHYLND-------------------------------------IPGL 80
           K           DH ++ D                                     +   
Sbjct: 59  KELMISEIDGPCDHAFILDAEDTLYVELFGLREVAQAVRRDARAAPALSAQGSKMYVVPF 118

Query: 81  ENPTSEVLAKWIWDQVKPVVPL-------LSAVMVKETCTAGCIY 118
             PT+E LA      + P+V         L+AV   ET      +
Sbjct: 119 A-PTAENLAAHWHALLAPLVSAHGKGGIFLAAVRAFETPNCEATF 162


>UniRef50_UPI0001B56D65 putative 6-pyruvoyl tetrahydropterin synthase n=1
          Tax=Streptomyces sp. C RepID=UPI0001B56D65
          Length = 146

 Score = 92.9 bits (230), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 31/79 (39%), Positives = 46/79 (58%), Gaps = 2/79 (2%)

Query: 3  STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG--EVDPHTGWIIDFAELKA 60
            T+ K+F F A+H L  +P  H C R+HGH+++V LE+ G  E     G++ D+ +L A
Sbjct: 1  MLTITKEFHFSASHVLDRLPGWHPCARMHGHNYVVVLELRGRREDLTEAGFVRDYRDLDA 60

Query: 61 AFKPTYERLDHHYLNDIPG 79
            K   E LDH +LN+  G
Sbjct: 61 FKKWVDETLDHRHLNEAMG 79


>UniRef50_C9ZBP0 Putative uncharacterized protein n=2 Tax=Streptomyces
           RepID=C9ZBP0_STRSW
          Length = 147

 Score = 92.5 bits (229), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 23/131 (17%), Positives = 41/131 (31%), Gaps = 14/131 (10%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              ++        AH            RLHG +F+V              ++D       
Sbjct: 15  PLFSITVRDHIMIAHSFRG-EVFGPAQRLHGATFLVDATFRRAELDDDNIVVDIGLATQE 73

Query: 62  FKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLS-----------AVMV 108
                  L++  L++ P     N ++E LAK I D++   +   +            V +
Sbjct: 74  LGAVVSELNYRNLDNEPAFAHTNTSTEFLAKVIADRLAERIHKGALGENAKGIAGIQVTL 133

Query: 109 KETCTAGCIYR 119
            E+  A   Y 
Sbjct: 134 HESHIAWASYE 144


>UniRef50_C0BIT7 6-pyruvoyl tetrahydropterin synthase n=6 Tax=Bacteroidetes
           RepID=C0BIT7_9BACT
          Length = 150

 Score = 92.1 bits (228), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 33/142 (23%), Positives = 55/142 (38%), Gaps = 30/142 (21%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHT-----GWIIDFAEL 58
             + K+F FE  H L        C  +HGHS+ + + + G           G ++DF+EL
Sbjct: 5   IRISKEFKFETGHALFGYD--GLCKNVHGHSYKLTVSLIGTPISDPNNVKFGMVMDFSEL 62

Query: 59  KAAFKP-TYERLDH-HYLNDIPGLE------------------NPTSEVLAKWIWDQVKP 98
           K        +  DH   LN     +                   PTSE++     D++K 
Sbjct: 63  KTIVNRCIVDPFDHATVLNVNSPHKELANAMESRGHKIVRVSYQPTSEMMIIDFADKIKK 122

Query: 99  VVP---LLSAVMVKETCTAGCI 117
            +P    L  ++++ET T+   
Sbjct: 123 ELPTHLGLHHLILRETETSYAE 144


>UniRef50_UPI000038E306 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=Ferroplasma
           acidarmanus fer1 RepID=UPI000038E306
          Length = 157

 Score = 91.7 bits (227), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 35/159 (22%), Positives = 57/159 (35%), Gaps = 44/159 (27%)

Query: 3   STTLF-----KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
              +      K  T+ + H +P      KC   HGH + + + I  +    +G  IDF  
Sbjct: 1   MYRIEVVGALKGLTWSSGHYVPD---NEKCKNFHGHDYSIDVIIDSDGVKASGMAIDFTI 57

Query: 58  LKAAFKPTYERLDHHYL---NDIPGLENP----------------------------TSE 86
           +K A KP  E +DH ++   +DI   ENP                            T+E
Sbjct: 58  VKQAIKPVIENMDHKFMIPEDDIRQNENPGFIDIYVRGKYRGTMSRSDIFAFPYSADTAE 117

Query: 87  VLAKWIWDQVKPVVPLL-----SAVMVKETCTAGCIYRG 120
            +AK+ +D++   +  L       V + E       Y  
Sbjct: 118 FIAKYCYDKIFAKLLGLMENFRLKVTIHEGPGNMATYNE 156


>UniRef50_B2RKC2 Putative uncharacterized protein n=3 Tax=Bacteria
           RepID=B2RKC2_PORG3
          Length = 139

 Score = 91.3 bits (226), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 28/139 (20%), Positives = 49/139 (35%), Gaps = 25/139 (17%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T  +       HR+      HKC  LHGH++ +    +       G ++DF  +K   
Sbjct: 1   MITAERYHDISMGHRVVGHD--HKCRHLHGHNYRIHFICSAPALDSIGRVVDFGVIKELL 58

Query: 63  -KPTYERLDHHYL----------------NDIPGLE-NPTSEVLAKWIWD-----QVKPV 99
            +   +  DH  +                +D+  +  NPT+E +A ++ +     Q+   
Sbjct: 59  CQWLEDHWDHKMMLWEQDPLLPALRATVPDDLVAVPFNPTAENMAVYLTEVVGPMQLAGT 118

Query: 100 VPLLSAVMVKETCTAGCIY 118
              L    V ET      Y
Sbjct: 119 GVTLIGCRVDETRKCSASY 137


>UniRef50_C3JCW3 6-pyruvoyl tetrahydrobiopterin synthase n=4 Tax=Bacteria
           RepID=C3JCW3_9PORP
          Length = 153

 Score = 90.9 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 33/135 (24%), Positives = 50/135 (37%), Gaps = 25/135 (18%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK-PTY 66
           +       HR+       KC  LHGH++ +    T       G +IDF  +K        
Sbjct: 17  RYHDISMGHRVVGHE--SKCRHLHGHNYRIHFVCTAPELDALGRVIDFGVIKERLCLWVE 74

Query: 67  ERLDHHY-----------LNDIPGLE------NPTSEVLAKWIWDQVKPV-----VPLLS 104
           E  DH             L +I   +      NPT+E +A+++ ++V P         L 
Sbjct: 75  EAWDHKMMLWQEDPLLPQLKEIAPEDLVIVPFNPTAEAMARYLVEEVAPHNLEGTGVTLV 134

Query: 105 AVMVKETCTAGCIYR 119
           A  V+ET      YR
Sbjct: 135 ACTVEETAKCRASYR 149


>UniRef50_B6IVH4 6-pyruvoyl tetrahydropterin synthase, putative n=16 Tax=Bacteria
           RepID=B6IVH4_RHOCS
          Length = 133

 Score = 90.9 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 27/131 (20%), Positives = 44/131 (33%), Gaps = 14/131 (10%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             +L        AH             LHG +F+V  E         G ++D     A  
Sbjct: 1   MYSLTVRDHMMIAHSFVGA-VFGPAQELHGATFLVDAEFRRPSLSADGLVVDIGLASALL 59

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP---------LLS--AVMVK 109
           K     L +  L+ +P     N T+E LA  I+ +++  +           L    V + 
Sbjct: 60  KEVLAPLTYRNLDGLPDFRGRNTTTEFLAGEIFRRLRARIADGALGDDGRALVGLRVELH 119

Query: 110 ETCTAGCIYRG 120
           E+  A   + G
Sbjct: 120 ESHVARAAFEG 130


>UniRef50_Q028J7 Putative uncharacterized protein n=1 Tax=Candidatus Solibacter
           usitatus Ellin6076 RepID=Q028J7_SOLUE
          Length = 141

 Score = 90.9 bits (225), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 32/133 (24%), Positives = 50/133 (37%), Gaps = 22/133 (16%)

Query: 7   FKDFTFEAAHRLP--------HVPEGHKCGRL--HGHSFMVRLEITGEVDPHTGWIIDFA 56
            + + F A+HRL         +     KC     HGH+++V + + G VD  TG  +D  
Sbjct: 2   TRRYQFAASHRLHSDQLSAEENRSLYGKCNNPYGHGHNYVVEVSVRGPVDEATGRTVDIV 61

Query: 57  ELKAAF-KPTYERLDHHYLN-DIPGLEN--PTSEVLAKWIWDQVKP--------VVPLLS 104
            L     +   +  DH  LN ++        TSE L   I  ++K           P L 
Sbjct: 62  LLDELVRREVVQPFDHRNLNAEVDAFTKAVATSENLGFEICRRLKRNWKEVFPGEWPKLE 121

Query: 105 AVMVKETCTAGCI 117
            + + ET      
Sbjct: 122 KIRIGETARNIFE 134


>UniRef50_A9KBA1 Queuosine biosynthesis protein n=7 Tax=Gammaproteobacteria
           RepID=A9KBA1_COXBN
          Length = 184

 Score = 90.2 bits (223), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 29/144 (20%), Positives = 49/144 (34%), Gaps = 32/144 (22%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
           M   + +    +  HR+    E  KC  +HGH   V +          G+ IDF E+K  
Sbjct: 1   MKQYISRRVEIDLGHRVM--DERFKCYSIHGHRASVHMTFEFSNQSEIGYCIDFKEIKRV 58

Query: 62  -FKPTYERLDHHY------------------------LNDIPGLENPTSEVLAKWIW--- 93
             +   ++ DH +                        LN      NPT+E +++ I+   
Sbjct: 59  GAQWIDDKFDHGFAANPKDKFVIEACQKTNSKYYLMSLNGKDNYCNPTAENISREIFLAL 118

Query: 94  DQVKPVVPLL--SAVMVKETCTAG 115
           + +    P L    +   ET    
Sbjct: 119 EILFEDYPGLKIHRLRFYETPNCW 142


>UniRef50_A7IHR5 Putative uncharacterized protein n=4 Tax=Bacteria
           RepID=A7IHR5_XANP2
          Length = 159

 Score = 89.8 bits (222), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 23/133 (17%), Positives = 46/133 (34%), Gaps = 16/133 (12%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +        AH             LHG +F+V +          G ++D      A 
Sbjct: 17  MYAVEVREHIMIAHSFKGA-LFGPAQALHGATFVVDVAFYRRELTVEGVVVDIGRAHDAL 75

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQV------------KPVVPLLSAVMV 108
           K     L++  L+++P     N T+EVL + ++D++               +  +  V +
Sbjct: 76  KAVLGPLNYKNLDELPDFAGRNTTTEVLCRHVFDKMAQAARAGELGAGSEALARI-RVTL 134

Query: 109 KETCTAGCIYRGE 121
            E+  A   +  +
Sbjct: 135 HESHVARAWFEAD 147


>UniRef50_O59602 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=9
           Tax=Thermococcaceae RepID=QUED_PYRHO
          Length = 157

 Score = 89.8 bits (222), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 32/151 (21%), Positives = 55/151 (36%), Gaps = 41/151 (27%)

Query: 2   MSTTLFKDF----TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           M   + +       F+++H L  +    KC R+HGH++ V +EI GE     G I DF  
Sbjct: 3   MRYIIKRKIYWTKEFDSSHFLE-LEYESKCKRIHGHTYKVEVEIEGE-LNEEGMIFDFTH 60

Query: 58  LKAAFKPTYERLDHHYL--------------------------NDIPGLENP--TSEVLA 89
           L    K     LDH  +                          +++  ++ P  T+E LA
Sbjct: 61  LSEIVKE----LDHRLIVSKEWVKEVGDLVIIEKNRKILKVPRDEVVIIDKPNVTAEYLA 116

Query: 90  KWIWDQVKPVVP---LLSAVMVKETCTAGCI 117
           +W  +++            V + E   +   
Sbjct: 117 EWFGERIAENAGSNIKKIKVRIWEDPRSYAE 147


>UniRef50_B8C0F3 Predicted protein n=1 Tax=Thalassiosira pseudonana
           RepID=B8C0F3_THAPS
          Length = 192

 Score = 89.8 bits (222), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 27/131 (20%), Positives = 46/131 (35%), Gaps = 16/131 (12%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAAFK 63
           TL    +   AH     P     G LHG ++ V +E           W+ID     A   
Sbjct: 60  TLTIRDSLMIAHSFHSHPSFGPAGGLHGATYTVDVEFASSTLHKECNWVIDIGVASAMVA 119

Query: 64  PTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPLLS------------AVMVK 109
                 ++  L+++ G +N   T+E + + I+D V   +                 V + 
Sbjct: 120 EVLTEYNYKNLDEVFG-DNVMTTTEFMCRAIFDGVVKKLKERYSDIDVDHFEGWIKVTLW 178

Query: 110 ETCTAGCIYRG 120
           E+  A   + G
Sbjct: 179 ESHKAWGSFEG 189


>UniRef50_B2HZD9 6-pyruvoyl-tetrahydropterin synthase n=31 Tax=Proteobacteria
           RepID=B2HZD9_ACIBC
          Length = 198

 Score = 89.8 bits (222), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 29/142 (20%), Positives = 51/142 (35%), Gaps = 29/142 (20%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K F FE AH + +         +HGHS+ V L +      H   + DF  LK   K
Sbjct: 1   MLIRKLFKFENAHVVRNCTSDRCKRSIHGHSYKVELLLKASKLDHGQMVYDFGLLKGVIK 60

Query: 64  PTYERLDH----------HYLNDIPGLE--------NPTSEVLAKWIWDQVKPVVP---- 101
             ++  DH           Y++              +P++E  ++  +   + V+     
Sbjct: 61  DLFDSFDHAICFWEKDDPQYIDACKTFSARWISLPVSPSAEQFSRIFFYLAQQVLQSTVT 120

Query: 102 -------LLSAVMVKETCTAGC 116
                   + +V+V ET T   
Sbjct: 121 QNGEGDVEVYSVIVHETDTGYA 142


>UniRef50_UPI0001B56179 putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Streptomyces
           sp. AA4 RepID=UPI0001B56179
          Length = 264

 Score = 89.0 bits (220), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 38/114 (33%), Positives = 51/114 (44%), Gaps = 10/114 (8%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           F FEAAH L  +PEGHKCGR HGHS+ V L +  +  P               +     L
Sbjct: 148 FAFEAAHHLEGLPEGHKCGRPHGHSYRVDLRLDQQTSPRRRA----RLRSRLAEYLDRYL 203

Query: 70  DHHYLNDIPGLENPTSEVLAKWIWDQV-----KPVVPLLSAVMVKETCTAGCIY 118
           DH  LN +  L+ PTSE+LA+ +               + AV V E+      +
Sbjct: 204 DHRDLNAVLELQ-PTSELLAEHLCAWTLSQADAREAAAVQAVRVWESPRRWAEF 256



 Score = 78.6 bits (193), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 36/105 (34%), Positives = 52/105 (49%), Gaps = 7/105 (6%)

Query: 10  FTFEAAHRLPHVPE-GHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
           F+F AAH L + P   +K GR HGH+F V +E+T       G++ D+AEL    +     
Sbjct: 28  FSFAAAHHLANPPATENKAGRPHGHTFTVEVELTDTELRAPGFVADYAELAPVGEYLKRE 87

Query: 69  LDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-----LLSAVMV 108
           LDH  LN +    + T++ LA+ I       +P      L AV V
Sbjct: 88  LDHRDLNALFTF-DTTTDALAQHITAWFLAHMPPERGKQLRAVRV 131


>UniRef50_B6R1Q6 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Pseudovibrio sp. JE062
           RepID=B6R1Q6_9RHOB
          Length = 139

 Score = 89.0 bits (220), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 25/131 (19%), Positives = 42/131 (32%), Gaps = 14/131 (10%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             ++        AH L          +LHG +  V + I  E     G +ID        
Sbjct: 1   MYSVEISNHIMIAHSLKG-EVFGPASQLHGLTAHVHVAIFAEELDENGIVIDIGNALDVL 59

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPV--VPLL---------SAVMVK 109
                  ++  L+D+P  +  N T + L  +I+ +V     +  L           V + 
Sbjct: 60  AEILHPFNYKNLDDLPQFKGRNTTVDFLCSYIYQRVCDAAYLHKLGREPGELSKVRVTIS 119

Query: 110 ETCTAGCIYRG 120
           E   A   Y  
Sbjct: 120 ENPNARASYEA 130


>UniRef50_Q8TX57 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Methanopyrus kandleri
           RepID=Q8TX57_METKA
          Length = 160

 Score = 89.0 bits (220), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 39/157 (24%), Positives = 61/157 (38%), Gaps = 43/157 (27%)

Query: 1   MMSTTLFKDF---TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           M    L        F A H +P      KCGRLHGH++ V +E+ GE     G++ DF E
Sbjct: 1   MPRVYLDGRELGLRFSACHVIPGH---GKCGRLHGHTYHVSVELLGERTEPHGFVYDFDE 57

Query: 58  LKAAFKPTYERLDHHYL----NDIPGLEN-------------------------PT---- 84
           LK+  +   + LDH  L    +++  +E                          PT    
Sbjct: 58  LKSTVRELIKPLDHRVLLPTESELFEIEESGNEITVRLSDGKRYVFPREDVVLIPTRSLS 117

Query: 85  SEVLAKWIWDQVKPVVPL----LSAVMVKETCTAGCI 117
           +E LA+++ D+++  +         V V E    G  
Sbjct: 118 AEDLAEYLADELERRLAGDNLKELRVRVDEGWGQGAE 154


>UniRef50_B0R4P7 6-pyruvoyltetrahydropterin synthase n=4 Tax=Halobacteriaceae
           RepID=B0R4P7_HALS3
          Length = 135

 Score = 88.6 bits (219), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 29/120 (24%), Positives = 42/120 (35%), Gaps = 7/120 (5%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           L     F A H L  VP     G +H H F   +   G      G+++D   + A     
Sbjct: 13  LTVRREFIAQHYLT-VPNPGPEGEVHSHRFTADVTFAGGELDEHGYLVDIDAVDAVLDDI 71

Query: 66  YERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCTAGCIYR 119
             R     LND       NP+ E  A+ I D++   +    P    V + E   A   + 
Sbjct: 72  EARYQDTLLNDHAEFGDANPSLERFAELIGDRIADGLGAAAPTRLTVRLWEDDLAWASHE 131


>UniRef50_B5JFE1 Putative uncharacterized protein n=1 Tax=Verrucomicrobiae bacterium
           DG1235 RepID=B5JFE1_9BACT
          Length = 149

 Score = 88.2 bits (218), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 31/149 (20%), Positives = 50/149 (33%), Gaps = 32/149 (21%)

Query: 3   STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
             T  K +     AHR         C ++HGH++        E     G+++DF +LK  
Sbjct: 1   MFTCKKTYADIPFAHR--QHRHDGHCAQIHGHNWSFTFTFGCEELDECGFVVDFGKLKPI 58

Query: 62  FKPTYERLDHHY-LNDIPGL---------------------ENPTSEVLAKWIWDQVKPV 99
                E LDH    N+   L                     +  +SE +A+ ++  + P 
Sbjct: 59  KAWIDENLDHACVFNEDDPLLADILAINEASGCKVYQPYVVDLCSSEGIARHVFKVINPK 118

Query: 100 VPL-------LSAVMVKETCTAGCIYRGE 121
           V         L +V V E       Y  +
Sbjct: 119 VKDMTGGRAFLISVEVVEDSRNSATYEPD 147


>UniRef50_Q18HJ5 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n=3 Tax=cellular
           organisms RepID=Q18HJ5_HALWD
          Length = 134

 Score = 87.9 bits (217), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 30/124 (24%), Positives = 47/124 (37%), Gaps = 9/124 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  L     F A H L         G++H H F V L   G+     G++++   +++  
Sbjct: 6   SYELAVQRDFIAQHVLTVPDPEPPEGQIHSHHFEVELHFAGDSLGEYGYLLNIVTVESIL 65

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV-------PLLSAVMVKETCT 113
           +   ER     LND+P  E  NP+ E  ++   D V   +       P    V + E   
Sbjct: 66  EDLVERYRDSVLNDLPEFEGLNPSVENFSRIFGDHVAERLSVAGETTPDQLRVQIWEDDA 125

Query: 114 AGCI 117
           A   
Sbjct: 126 AWAS 129


>UniRef50_A9B2M7 6-pyruvoyl tetrahydrobiopterin synthase n=1 Tax=Herpetosiphon
           aurantiacus ATCC 23779 RepID=A9B2M7_HERA2
          Length = 165

 Score = 87.9 bits (217), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 34/160 (21%), Positives = 56/160 (35%), Gaps = 49/160 (30%)

Query: 2   MSTTLFK------DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDF 55
           MS  +++         F AAH +       KC RLHGH++ V +E+ G +     +++DF
Sbjct: 1   MSQRIYRLQVTKDQLGFAAAHFIT---MRGKCERLHGHNYRVTVEVEGFLCEDQ-YVVDF 56

Query: 56  AELKAAFKPTYERLDHHYL------------ND--------------------IPGLENP 83
             LK         LDH  L            N+                    +  ++N 
Sbjct: 57  GVLKKHAAEIARTLDHRVLLAAENPKIEYSQNEQHLTVRYEDKYYVFPIAEVIMLPIQNT 116

Query: 84  TSEVLAKWIWDQVKPVVP-----LLSAVMVK--ETCTAGC 116
           T+E+LA +   ++   +       L  V V   E      
Sbjct: 117 TAELLATYFCAELCERLRQDGVDTLKMVGVWVSEGPGQQA 156


>UniRef50_O27296 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=5
           Tax=Euryarchaeota RepID=QUED_METTH
          Length = 161

 Score = 87.9 bits (217), Expect = 9e-17,   Method: Composition-based stats.
 Identities = 32/158 (20%), Positives = 56/158 (35%), Gaps = 43/158 (27%)

Query: 1   MMSTTL---FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           MM   +     +  F AAH +P       CG +HGHS++V +++ G+     G++ DF +
Sbjct: 3   MMKIVINGIHANLRFSAAHMIPEHES---CGCIHGHSYIVDVKVEGKRSGKHGFVADFKD 59

Query: 58  LKAAFKPTYERLDHHYLN--------------------------------DIPGLENPTS 85
           +K   +      DH  L                                  +  LE+ ++
Sbjct: 60  VKDIVRRICSEFDHKLLIPLRNPLINFTSTTRTVKFEIAGKKYSIPEEDCCLMDLESSSA 119

Query: 86  EVLAKWIWDQVKPVVPLLS-----AVMVKETCTAGCIY 118
           E L+++    +   +          V V E    G IY
Sbjct: 120 EELSRYFAATLFKELSSKYDISSVEVCVNEGIGQGAIY 157


>UniRef50_Q979P1 Putative uncharacterized protein TVG1150731 n=2 Tax=Thermoplasma
           RepID=Q979P1_THEVO
          Length = 159

 Score = 87.9 bits (217), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 41/158 (25%), Positives = 62/158 (39%), Gaps = 45/158 (28%)

Query: 2   MSTTL---FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAEL 58
           M  T+   + +  F AAH +P      KC RLHGH + + + + GE+    G +IDF EL
Sbjct: 1   MKLTVNGWYTNMRFSAAHFIPSHY---KCSRLHGHDYGIIINVDGEM--QDGMLIDFIEL 55

Query: 59  KAAFKPTYERLDHHYL---------------------ND-----------IPGLENPTSE 86
           K A +     +DH  L                     ND           I  + N TSE
Sbjct: 56  KNAIRSVINEMDHKLLVPGKANIAKYNESTNEYEISYNDKRMIIPAEYVYICDVYNTTSE 115

Query: 87  VLAKWIWDQVKPVVP-----LLSAVMVKETCTAGCIYR 119
            L++++ ++V   +          V V+E    G  Y 
Sbjct: 116 ELSRFVAEKVGAKIGKRKNLRSIEVSVEEGPGQGVFYS 153


>UniRef50_A4TYV7 Putative uncharacterized protein n=1 Tax=Magnetospirillum
           gryphiswaldense RepID=A4TYV7_9PROT
          Length = 176

 Score = 87.5 bits (216), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 32/172 (18%), Positives = 50/172 (29%), Gaps = 59/172 (34%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG----WIIDFAELK 59
             + +    +A HR+     G KC  +HGH + +          H G     ++DF  LK
Sbjct: 5   YRISRRIDIDAGHRIM--THGSKCRHVHGHRYGIEAVCEAVDLHHDGEQTDMVLDFGFLK 62

Query: 60  -AAFKPTYERLDHHYLNDIPGLE------------------------------------- 81
               K   E  DH ++  +  +E                                     
Sbjct: 63  EEMLKAIDEPCDHGFIAALADVELLTMFTPLGGDTAEWLADLEAQVREKGEATTTRTRLL 122

Query: 82  --------NPTSEVLAKWIWDQVKPVV-------PLLSAVMVKETCTAGCIY 118
                    PT+E LA+  + ++   V         L  V V ET      Y
Sbjct: 123 TKLTVVPFQPTAECLARHWFIKLAEPVKQRSGGAARLLLVRVFETPNCAAEY 174


>UniRef50_D1X5B9 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Streptomyces sp. ACT-1 RepID=D1X5B9_9ACTO
          Length = 234

 Score = 87.5 bits (216), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 34/108 (31%), Positives = 48/108 (44%), Gaps = 12/108 (11%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
            FEA H L  +P GH C R HGHS++V            G  +   E         + LD
Sbjct: 134 EFEATHHLEGLPAGHPCARRHGHSYLV------SAADADGCSVPVPE--ELAWHIGKALD 185

Query: 71  HHYLNDIPGLENPTSEVLAKWIWDQVKPVVPLLSAVMVKETCTAGCIY 118
              LN+   + NPTSE LA+++ D +       + V V ET ++   Y
Sbjct: 186 GSVLNESLDI-NPTSEHLARYLSDWMDR---GPATVRVSETESSWAQY 229



 Score = 75.9 bits (186), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 32/112 (28%), Positives = 48/112 (42%), Gaps = 15/112 (13%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
           S  + K F FEA  +L    +        GHSF     + G      G++IDF  L A  
Sbjct: 19  SWRIGKQFRFEATRQLNGRAD--------GHSFTAEAVLGGLELDPVGFVIDFGRLSALK 70

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPVVP-----LLSAVMVK 109
           +   +RLDH  LND     + + E LA ++ D  +  +P      L  V ++
Sbjct: 71  RHIDDRLDHQCLNDRVP--DASDEGLAAYLTDWARTHLPDDVAESLVDVRIR 120


>UniRef50_Q9HHN6 Vng6306c n=3 Tax=Halobacteriaceae RepID=Q9HHN6_HALSA
          Length = 150

 Score = 85.9 bits (212), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 31/130 (23%), Positives = 51/130 (39%), Gaps = 28/130 (21%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           +     A HRL H     KC R HGH++ + +EITG++    GW++D    K        
Sbjct: 25  RPIRISAGHRLQHHD--GKCSRPHGHNYEISVEITGQLTDE-GWVVD----KGTVTAVVS 77

Query: 68  RLDHHYLND------------------IPGLENPTSEVLAKWIWDQVKPVVPLL---SAV 106
             DH +L +                  +   + PT+EV+   +  ++   +P      +V
Sbjct: 78  DWDHRFLLEDGDPLVDAFREAGDGDAVVVLEQPPTAEVMGVVLERKLHDALPETVSAVSV 137

Query: 107 MVKETCTAGC 116
            V ET     
Sbjct: 138 TVAETPALTA 147


>UniRef50_B7FYC8 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FYC8_PHATR
          Length = 157

 Score = 85.9 bits (212), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 22/127 (17%), Positives = 44/127 (34%), Gaps = 9/127 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-HTGWIIDFAELKAA 61
           S  L    +   AH     P     G +HG ++   +E + +     T W++D  +    
Sbjct: 27  SFRLGIRDSLMIAHSFHRHPAFGPAGGMHGATYTCDVEFSKDTLDPDTNWVMDIGKASEL 86

Query: 62  FKPTYERLDHHYLNDIPGLEN-PTSEVLAKWIWDQVKPVVPL-------LSAVMVKETCT 113
                 + +   L+++       T+E + K I   +  ++            V + E+  
Sbjct: 87  LCTVLAKYNLKNLDEVFPNGQLTTTEFMCKQIHMDLVDLIRREFHDFHGEVCVKLWESHK 146

Query: 114 AGCIYRG 120
           A   Y G
Sbjct: 147 AWAAYSG 153


>UniRef50_Q4JA84 Conserved Archaeal protein n=12 Tax=Sulfolobaceae
           RepID=Q4JA84_SULAC
          Length = 139

 Score = 85.9 bits (212), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 29/139 (20%), Positives = 55/139 (39%), Gaps = 29/139 (20%)

Query: 2   MSTTLFKD-FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG-EVDPHTGWIIDFAELK 59
           M   +  + F+F++AH            ++HGH++ + +EI G +VD ++G++IDF  L 
Sbjct: 1   MKVVIGVEGFSFDSAHYTLSSKGND---QIHGHTYKLSVEIEGQDVDKNSGFVIDFMILT 57

Query: 60  AAFKPTYERLDHHYL------------------NDIPGLENPTSE----VLAKWIWDQVK 97
                     DH  +                    I   + PT E     +AK I+++++
Sbjct: 58  KIIHEVIREWDHKLIIPSRDARKIELKGPFKVEYKIIEEDFPTVEYIGSEIAKDIYEKLE 117

Query: 98  PVVPLLSAVMVKETCTAGC 116
                   V + E   +  
Sbjct: 118 KKFK--VRVKIYEGENSYA 134


>UniRef50_B2KCS0 Putative uncharacterized protein n=1 Tax=Elusimicrobium minutum
           Pei191 RepID=B2KCS0_ELUMP
          Length = 120

 Score = 85.9 bits (212), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 36/121 (29%), Positives = 55/121 (45%), Gaps = 9/121 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L K  +F AAH      EG      H H+F   +++ G  +   G++ DF  ++   
Sbjct: 5   KVYLIKKSSFTAAHS----HEGMLNEAQHTHTFHYEIKLCGFTNNE-GFLTDFRIVEEDM 59

Query: 63  KPTY-ERLDHHYLNDIPGLENPTSEVLAKWIWDQVKPV-VPLLSAVMVKETCTAGCIYRG 120
                + L    LN    L++PT+E LA WI+ ++K     +L  V V ET  +  IY G
Sbjct: 60  NTLINKELKDKNLN--IFLKDPTTEKLAVWIFRRLKDSYGKMLHCVTVYETPQSAVIYEG 117

Query: 121 E 121
           E
Sbjct: 118 E 118


>UniRef50_A2BJ89 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Hyperthermus butylicus
           DSM 5456 RepID=A2BJ89_HYPBU
          Length = 126

 Score = 85.5 bits (211), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 15/116 (12%)

Query: 12  FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERLD 70
           F AAHR+   P   +CG++HGH++ V + +           +D   L+    +  ++R D
Sbjct: 10  FSAAHRIEGHP---RCGKIHGHNYRVCIVVR----EERPLQVDLDALEEWLERNVFQRFD 62

Query: 71  HHYLNDIPGLEN------PTSEVLAKWIWDQVKPVVP-LLSAVMVKETCTAGCIYR 119
           H YLN +    +       TSE LA  I D ++   P  +  V V ET      YR
Sbjct: 63  HQYLNKVLAAPDKDEKLVVTSEELAVLIADMLEQAFPGRVEYVEVCETENLCIEYR 118


>UniRef50_B6KR79 Putative uncharacterized protein n=3 Tax=Toxoplasma gondii
           RepID=B6KR79_TOXGO
          Length = 475

 Score = 84.4 bits (208), Expect = 9e-16,   Method: Composition-based stats.
 Identities = 31/154 (20%), Positives = 53/154 (34%), Gaps = 46/154 (29%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
             F   H + +        RLHGH++ V ++I G V P  G+I+DF ++K   +   + L
Sbjct: 325 MKFNCGHFIAYRGFR---ERLHGHNYSVTVKIGGIVGPD-GYILDFGDIKQTAREVCKSL 380

Query: 70  DHHYL---------------------NDIPGLENP------------TSEVLAKWIWD-- 94
           D H +                      D    + P            ++E +  ++W   
Sbjct: 381 DEHLIVPMKSDVLDITQEGQSIIIRCEDGAEFKVPCSDCKCLPIVHSSAEEITCYLWQCI 440

Query: 95  -------QVKPVVPLLSAVMVKETCTAGCIYRGE 121
                   +K        V V ET +    +R E
Sbjct: 441 VDKVTVPLLKKRGATWVEVAVWETPSQMASFRRE 474


>UniRef50_Q1LPD9 6-pyruvoyl-tetrahydropterin synthase-like protein n=4
           Tax=Proteobacteria RepID=Q1LPD9_RALME
          Length = 193

 Score = 83.6 bits (206), Expect = 2e-15,   Method: Composition-based stats.
 Identities = 31/147 (21%), Positives = 48/147 (32%), Gaps = 29/147 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K F FE AH +           +HGHS+ + L +      H   + DF  LK    
Sbjct: 7   MLIRKLFRFENAHIVRGCSTRRCSHSIHGHSYKIELLLEAHSLDHGQMVYDFGLLKGGAF 66

Query: 64  PTYERLDHHY---LNDIPGLE---------------NPTSEVLAKWIWDQVKPVVP---- 101
              +  DH       D P                  +P++E  ++  +  V  V+     
Sbjct: 67  TLIDAFDHAVTLWTGDDPAYLAAMRQHSERWVLIPVSPSAEQFSRLFFLLVDAVLATTAL 126

Query: 102 -------LLSAVMVKETCTAGCIYRGE 121
                   L +V+V ET T       E
Sbjct: 127 RNGEGDVRLHSVIVHETETGYAQCFRE 153


>UniRef50_C1YMA8 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Nocardiopsis
          dassonvillei subsp. dassonvillei DSM 43111
          RepID=C1YMA8_NOCDA
          Length = 174

 Score = 82.8 bits (204), Expect = 3e-15,   Method: Composition-based stats.
 Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 6/91 (6%)

Query: 2  MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
          M+  +     FE AHRLPH+    KC  LHGHS+   + ++       G +++F   K A
Sbjct: 1  MTHRIRVRHNFETAHRLPHLS--GKCMNLHGHSWWAEVSVSAPALSEDGTVVEFGAFKKA 58

Query: 62 FKPTYE-RLDHHYLNDIPGLENPTSEVLAKW 91
           +   +  LDH     + G  +P + VLA+ 
Sbjct: 59 LRAFVDTHLDHG---AMLGAGDPLAAVLAEH 86


>UniRef50_D2RQ20 6-pyruvoyl-tetrahydropterin synthase-like protein n=1
           Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RQ20_9EURY
          Length = 174

 Score = 82.5 bits (203), Expect = 4e-15,   Method: Composition-based stats.
 Identities = 29/125 (23%), Positives = 49/125 (39%), Gaps = 28/125 (22%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           +       HR+ H     KC R HGH++ V + + GE+    GW+ D  ++        +
Sbjct: 48  RPIRISTGHRIRHHD--GKCARPHGHNYEVAVTVVGELADE-GWVADKGDI----TDVID 100

Query: 68  RLDHHYLND-----IPGLE-------------NPTSEVLAKWIWDQVKPVVPLL---SAV 106
             DH +L +     I   E              PT+EV++  +  ++   +P       V
Sbjct: 101 EWDHMFLLEAGDPLIEAFEASGDSDAVVVLEHPPTAEVMSVLLERKLLAALPETVSDVRV 160

Query: 107 MVKET 111
            V ET
Sbjct: 161 QVNET 165


>UniRef50_D0MWX1 Putative uncharacterized protein n=2 Tax=Phytophthora infestans
           T30-4 RepID=D0MWX1_PHYIN
          Length = 244

 Score = 82.1 bits (202), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 33/160 (20%), Positives = 56/160 (35%), Gaps = 47/160 (29%)

Query: 3   STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              + KD+  F AAH + +     K   LHGH++ + + ITG+V P  G+++DF E+K  
Sbjct: 84  KVHVSKDYMKFNAAHFIAYKGFREK---LHGHNYRLAVTITGQVGPD-GYVVDFGEIKKI 139

Query: 62  FKPTYERLD---------------------HHYLNDIPGLENP------------TSEVL 88
            +   + L+                     H    D+     P            ++E L
Sbjct: 140 SRVICKDLNESFLVPMNSDALKISFDGTNVHILTEDMAKFSFPKADCSLLPIVHSSAEEL 199

Query: 89  AKWIWDQVKPVV---------PLLSAVMVKETCTAGCIYR 119
           A +I +Q+                  V + E       Y 
Sbjct: 200 AIYISNQLIDAFTLVALLDRGVRKIEVSISEANQQFASYE 239


>UniRef50_A6DNS1 Putative uncharacterized protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DNS1_9BACT
          Length = 144

 Score = 81.7 bits (201), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 31/146 (21%), Positives = 47/146 (32%), Gaps = 29/146 (19%)

Query: 3   STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
                K F     AHR     +   C  +HG+   +      +      W++DF  LK  
Sbjct: 1   MYRSTKSFFYLPCAHR--QWRDDGDCQLVHGYDRSIHFTFESDGLDDKCWVMDFGGLKHI 58

Query: 62  FKPTYERLDHHYL-NDIPG------------------LENPTSEVLAKWIWDQVKPVVP- 101
                ++ DH  L N+                     L N   E  AK+I+D V P V  
Sbjct: 59  KAWLEDKFDHTLLINEDDPEMAFFEEMDRKGLCRLRVLPNIGMEGSAKYIFDYVDPWVQE 118

Query: 102 ------LLSAVMVKETCTAGCIYRGE 121
                  + +V  +E      IY  +
Sbjct: 119 QTDGRVRVFSVECRENEKNSAIYYRD 144


>UniRef50_A4FWS8 6-pyruvoyl tetrahydropterin synthase n=8 Tax=Methanococcus
           RepID=A4FWS8_METM5
          Length = 167

 Score = 81.7 bits (201), Expect = 7e-15,   Method: Composition-based stats.
 Identities = 30/158 (18%), Positives = 52/158 (32%), Gaps = 48/158 (30%)

Query: 6   LFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPT 65
           ++    F +AH +        CG +HGHS+ V ++++GE     G++ DF  LK   K  
Sbjct: 8   IYAGLRFSSAHIVFGHDS---CGVIHGHSYYVDVKLSGEPSGEFGFVCDFKILKQIVKEL 64

Query: 66  YERLDHHYLN-------------------------------------DIPGLENPTSEVL 88
              LDH  L                                      ++  L++ T+E L
Sbjct: 65  CGELDHKLLVPRDHENMEYSLEGDSIYLEYVEKSGKVKKYMFPVEDINLLPLKSTTAEDL 124

Query: 89  AKWIWDQVKPVVP--------LLSAVMVKETCTAGCIY 118
           + +    ++  +               V E    G  Y
Sbjct: 125 SIYFAKFIEDKLQKMGLEKSIEWIETTVNEGIGQGARY 162


>UniRef50_Q1D8H8 Putative uncharacterized protein n=1 Tax=Myxococcus xanthus DK 1622
           RepID=Q1D8H8_MYXXD
          Length = 209

 Score = 81.3 bits (200), Expect = 8e-15,   Method: Composition-based stats.
 Identities = 28/123 (22%), Positives = 50/123 (40%), Gaps = 9/123 (7%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              L     F+A+H +       +   LH H + VR+ +      H   IIDF +L+   
Sbjct: 84  MHYLSLTAEFKASHAVTF--PDGQREPLHTHDWWVRVWVKARALNHWDVIIDFKDLQDII 141

Query: 63  KPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL---LSAVMVKETCTA--G 115
                 L    +N+ P  +  N T+E + ++++ QV+  +P    L  V ++ T      
Sbjct: 142 VRVCRELHDTNINEHPYFKTVNCTAERVTEYVFKQVESGLPEGVTLDRVHLRRTGGELPE 201

Query: 116 CIY 118
             Y
Sbjct: 202 AEY 204


>UniRef50_D0LLG1 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Haliangium ochraceum
           DSM 14365 RepID=D0LLG1_HALO1
          Length = 128

 Score = 79.8 bits (196), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 23/123 (18%), Positives = 46/123 (37%), Gaps = 7/123 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             +L      + AH             LH  ++ V      E       ++DF   + A 
Sbjct: 1   MFSLRIADYLKCAHSFKG-EIFGIAQILHIITYEVEAVFIVEELDENNLVVDFGASQQAL 59

Query: 63  KPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVPLLS----AVMVKETCTAGC 116
                 +++  L+++P L  +N T+E L ++I + +   V  L      + ++E+  A  
Sbjct: 60  TAIIGTMNYKNLDELPELNGKNTTTEFLCRYIHEYMSKAVEDLFSGTLRITMRESTVAEV 119

Query: 117 IYR 119
            Y 
Sbjct: 120 SYE 122


>UniRef50_Q0AV03 6-pyruvoyl-tetrahydropterin synthase related domain; conserved
           membrane protein n=1 Tax=Syntrophomonas wolfei subsp.
           wolfei str. Goettingen RepID=Q0AV03_SYNWW
          Length = 1166

 Score = 79.4 bits (195), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 22/107 (20%), Positives = 42/107 (39%), Gaps = 11/107 (10%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHH 72
            A H +           +H HS+ V  E+        G  I+F+ +  A        ++ 
Sbjct: 170 NARHFVIFGGTTGP---VHAHSWQVETEVDVPR--EIGDTIEFSRVSQAVSAALGPYENT 224

Query: 73  YLNDIPGLE--NPTSEVLAKWIWDQVKPVVP----LLSAVMVKETCT 113
            LN +   +   PT+E +A + +++V   +      L  + + ET T
Sbjct: 225 ILNQVHPFDLIQPTTENIAMYFFNRVDEYLAKLGLKLYQLSLWETPT 271


>UniRef50_A9LH53 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=uncultured
           planctomycete 13FN RepID=A9LH53_9BACT
          Length = 164

 Score = 79.0 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 34/141 (24%), Positives = 53/141 (37%), Gaps = 27/141 (19%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + K + F AAHR  +     KC  LHGH + V+     E D     +  F +  A  +
Sbjct: 1   MIIQKQYKFYAAHR--NETLQDKCSNLHGHRYGVKCHFQVERDGDISTL--FGDFDAKVE 56

Query: 64  PTYER-LDHHYL-NDIPG--------------------LENPTS-EVLAKWIWDQVKPVV 100
           P  ++  DH  L N                         + PTS E L   ++ ++  + 
Sbjct: 57  PWLKQNYDHGMLINRHDSLYESLEMHMERTGESLRLNVFDGPTSVENLCHKLFTEITQLG 116

Query: 101 PLLSAVMVKETCTAGCIYRGE 121
             L+ + V+ET T    Y  E
Sbjct: 117 FRLATLEVQETDTFVVSYTRE 137


>UniRef50_Q4JIS7 Putative 6-pyruvoyl tetrahydropterin synthase n=1 Tax=uncultured
           bacterium BAC10-4 RepID=Q4JIS7_9BACT
          Length = 162

 Score = 79.0 bits (194), Expect = 4e-14,   Method: Composition-based stats.
 Identities = 30/162 (18%), Positives = 55/162 (33%), Gaps = 46/162 (28%)

Query: 1   MMSTTLFKDFT---FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           M    +  +     F   H + +      C  LHGH++  R+E+ G+      ++ DF  
Sbjct: 1   MAEYKIVVEKDYLVFACGHFITY---EGSCETLHGHNYRARVELEGD-LDENYYVWDFVS 56

Query: 58  LKAAFKPTYERLDHHYL--------------------------------NDIPGLENPTS 85
           LK   +   + +DH  L                                     + N T+
Sbjct: 57  LKRLMRRLVDEMDHRMLLPLQNPALTLREEDGHVHVLYKDRRYVFPKQDVAFLPIPNTTA 116

Query: 86  EVLAKWIWDQVKPVVPLL-------SAVMVKETCTAGCIYRG 120
           E+LA+++  +V+  +  L        AV V+E+       R 
Sbjct: 117 EMLARYLLGRVRDELRKLGGGRLKALAVEVEESFGQSGWCRE 158


>UniRef50_D2EHH0 6-pyruvoyl-tetrahydropterin synthase n=1 Tax=Pediococcus
           acidilactici 7_4 RepID=D2EHH0_PEDAC
          Length = 123

 Score = 79.0 bits (194), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 25/120 (20%), Positives = 48/120 (40%), Gaps = 14/120 (11%)

Query: 1   MMSTTLFK-DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
           M     +K      A+H +       K    H H++ V  EI  +       I+ F +++
Sbjct: 1   MPLVHTYKIKSYVNASHAMRWKDGEGK---QHNHTWEVVCEIKSK---DDHMIV-FRDIE 53

Query: 60  AAFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCT 113
              +         +LN++P  +  NPT E +  W++D +  ++      L  + V E+ T
Sbjct: 54  KKIQDVLGSFSGQFLNELPYFKEINPTVENVTIWLFDLLSSILEELSAKLVRIEVGESPT 113


>UniRef50_A4EHB1 6-pyruvoyl tetrahydropterin synthase n=14 Tax=Bacteria
           RepID=A4EHB1_9RHOB
          Length = 131

 Score = 78.6 bits (193), Expect = 5e-14,   Method: Composition-based stats.
 Identities = 25/131 (19%), Positives = 45/131 (34%), Gaps = 13/131 (9%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
              +        AH LP  P       +HG +F+V      +     G ++D      A 
Sbjct: 1   MFAVEVRDHVMIAHSLPS-PVFGPAQGMHGATFVVDAAFYTKDLDENGLVVDMGLALEAL 59

Query: 63  KPTYERLDHHYLNDIPGLEN--PTSEVLAKWIWDQVKPVVPLL----------SAVMVKE 110
               + L +  L+++P  +    T+E L   IW Q++                  V ++E
Sbjct: 60  ADALKPLKYANLDEVPAFKGKITTTEFLCHHIWQQLRETAKTTGLGDNGRVCRIKVSLEE 119

Query: 111 TCTAGCIYRGE 121
           +  A   Y  +
Sbjct: 120 SHVARGWYEAD 130


>UniRef50_Q3ISX3 Homolog to 6-pyruvoyltetrahydropterin synthase (4.2.3.12) n=1
           Tax=Natronomonas pharaonis DSM 2160 RepID=Q3ISX3_NATPD
          Length = 123

 Score = 78.6 bits (193), Expect = 6e-14,   Method: Composition-based stats.
 Identities = 31/120 (25%), Positives = 44/120 (36%), Gaps = 6/120 (5%)

Query: 3   STTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
             T+    TF A H L           LH H+F   +   G      G+++D    + A 
Sbjct: 1   MFTVTVTETFVAQHFLTLPDPPADEATLHSHTFEAEVTFRGPELGPHGYLLDIDAAREAL 60

Query: 63  KPTYERLDHHYLNDIPGLENPTSEVLAKWIWDQVK----PVVPLLSAVMVKETCTAGCIY 118
               E      LND     NP+ E LA  ++  +     P V  L+ V + E  TA   Y
Sbjct: 61  SAAAETYRDETLNDHLD-GNPSVERLAVALFADLSSLEAPAVTELT-VAISEDDTAVASY 118


>UniRef50_Q6AKY1 Related to 6-pyruvoyl-tetrahydropterin synthase n=1
           Tax=Desulfotalea psychrophila RepID=Q6AKY1_DESPS
          Length = 80

 Score = 78.2 bits (192), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 29/76 (38%), Positives = 40/76 (52%), Gaps = 6/76 (7%)

Query: 51  WIIDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEVLAKWIWDQVKPVVP----LLS 104
             +DF  LK   K   E LDH  LN++P    +NP+SE +A +I+D + PV+      L 
Sbjct: 1   MGLDFTVLKKKTKEVIELLDHRDLNNLPYFKEKNPSSEHIAIFIFDILAPVLEHKRYSLY 60

Query: 105 AVMVKETCTAGCIYRG 120
           +V V ET   GC Y  
Sbjct: 61  SVRVMETDNQGCTYFA 76


>UniRef50_Q9ZKR8 6-carboxy-5,6,7,8-tetrahydropterin synthase n=14 Tax=Helicobacter
           RepID=QUED_HELPJ
          Length = 200

 Score = 77.5 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 21/143 (14%), Positives = 47/143 (32%), Gaps = 29/143 (20%)

Query: 4   TTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK 63
             + + + F A+H + +         +HGH++ V + I      +    +DF  ++   +
Sbjct: 1   MVIRRLYKFCASHVVRNCSSLKCAQNIHGHNYEVEVFIETNRLDNANMALDFGLMQQEMQ 60

Query: 64  PTYERLDHHYL---NDIPGLE---------------NPTSEVLAKWIWDQVKPVVPL--- 102
              +  DH +     + P  +               N ++E  A      +  ++     
Sbjct: 61  TFIDSFDHAHHFWDKESPEFQRFIENHCVRYVKCSFNLSAESYALMFLYYLTKILQKSVF 120

Query: 103 --------LSAVMVKETCTAGCI 117
                   +S+V V ET      
Sbjct: 121 SNNEGELKVSSVRVHETKNGYAE 143


>UniRef50_A5GJQ8 6-pyruvoyl tetrahydropterin synthase n=24 Tax=Cyanobacteria
           RepID=A5GJQ8_SYNPW
          Length = 166

 Score = 77.5 bits (190), Expect = 1e-13,   Method: Composition-based stats.
 Identities = 26/144 (18%), Positives = 45/144 (31%), Gaps = 29/144 (20%)

Query: 4   TTLFKDFT-FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAF 62
            T  K F  +   HR         C  +HG+S    +          G+++DF+ L+   
Sbjct: 8   YTCSKQFDGYPCCHR--QWQHPGHCRFVHGYSRSFTVWFAATALDACGFVVDFSSLRPLE 65

Query: 63  KPTYERLDHHYLN-------------------DIPGLENPTSEVLAKWIWDQVKPVVPL- 102
           K   ++ DH +L                    D+  +EN   E  A+ +W     ++   
Sbjct: 66  KQLRDQFDHTFLVNADDPLMEQWQALHAQDALDLRVMENVGMEASARLVWGWANTLLKER 125

Query: 103 ------LSAVMVKETCTAGCIYRG 120
                    V  +E       Y  
Sbjct: 126 DGGRSCCWKVEARENRANSACYEA 149


>UniRef50_B9LV86 6-pyruvoyl tetrahydropterin synthase n=1 Tax=Halorubrum
           lacusprofundi ATCC 49239 RepID=B9LV86_HALLT
          Length = 153

 Score = 76.7 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 29/130 (22%), Positives = 51/130 (39%), Gaps = 28/130 (21%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
               + HR+ H     KC R HGH++ + +E+TG+     GW++D  +         +  
Sbjct: 31  IRISSGHRILHHE--GKCSRPHGHNYEITVEVTGQ-LTEEGWVVDKGD----VTDVIDAW 83

Query: 70  DHHYLND-----IPGLE-------------NPTSEVLAKWIWDQVKPVVP---LLSAVMV 108
           DH +L +     +   E              PT+EV++  +  ++    P      +V V
Sbjct: 84  DHRFLVEEGDPLVDAFEASGDSDALVVLDHPPTAEVMSVLLEQRMLDAFPDTVSDVSVSV 143

Query: 109 KETCTAGCIY 118
            ET      Y
Sbjct: 144 SETGELCASY 153


>UniRef50_D2R465 6-pyruvoyl tetrahydrobiopterin synthase; K01737 6-pyruvoyl
           tetrahydrobiopterin synthase n=1 Tax=Pirellula staleyi
           DSM 6068 RepID=D2R465_9PLAN
          Length = 182

 Score = 76.7 bits (188), Expect = 2e-13,   Method: Composition-based stats.
 Identities = 34/157 (21%), Positives = 56/157 (35%), Gaps = 47/157 (29%)

Query: 3   STTLFKDFT-FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
              L K+   F AAH +     G+ C  LHGH++ V +EI         ++IDF  ++  
Sbjct: 18  RIRLEKEAHVFAAAHFITF--AGNICEPLHGHNYGVAVEIEAP-LDENQYVIDFIAVRDE 74

Query: 62  FKPTYERLDHHYL------------ND--------------------IPGLENPTSEVLA 89
                + LDH  L            ++                    +  L N TSE+LA
Sbjct: 75  LTAITQTLDHRMLLPTSHPLIQVTADEREVTARFGDKRWVFPRTDCVLLPLTNTTSELLA 134

Query: 90  KWI----WDQVKPVVPLLS-------AVMVKETCTAG 115
           ++I     +++   +P          +V V E     
Sbjct: 135 RYIGLALRERLAARLPAQVVGSITRFSVEVDENHGQR 171


>UniRef50_Q4LA59 Similar to 6-pyruvoyl tetrahydropterin synthase n=1
           Tax=Staphylococcus haemolyticus JCSC1435
           RepID=Q4LA59_STAHJ
          Length = 143

 Score = 76.3 bits (187), Expect = 3e-13,   Method: Composition-based stats.
 Identities = 26/92 (28%), Positives = 47/92 (51%), Gaps = 5/92 (5%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER-LDHHYLNDIPGLENPTSEVL 88
           LH HS+ + +++   +  + G  +DF E+ A +    E  L+H  +N+     N T+E +
Sbjct: 45  LHNHSYRLYVDVLSPIGDY-GLGLDFNEVDAIYNKVIEPKLNHQLINETLPDMNTTAENI 103

Query: 89  AKWIWDQVKPVVPL---LSAVMVKETCTAGCI 117
           A WIWD+ +  +P    + A+ + ET   G  
Sbjct: 104 AMWIWDEFEQHLPGEHCMYALQLFETDRHGVS 135


>UniRef50_A8AAK9 Putative uncharacterized protein n=1 Tax=Ignicoccus hospitalis
           KIN4/I RepID=A8AAK9_IGNH4
          Length = 150

 Score = 75.5 bits (185), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 27/149 (18%), Positives = 50/149 (33%), Gaps = 33/149 (22%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M  T +  +  F AAH     P     G LHGH++ V++ +  E      W++D  +L+ 
Sbjct: 1   MTLTCISVEEKFPAAHY--TNPRLSPAGTLHGHNWRVKVTVCKEGVSA--WVVDAVKLRE 56

Query: 61  AFKPTYERLDHHYL----------------------------NDIPGLENPTSEVLAKWI 92
           A     + L    L                              +      + E++A ++
Sbjct: 57  ALNDIIDPLRFSLLVPETDAKLWLGPKGLKELLEEALGIRVRVAVLPYPIVSGEIVAHYV 116

Query: 93  WDQVKPVV-PLLSAVMVKETCTAGCIYRG 120
             ++K  +      V V+E+      Y  
Sbjct: 117 CSRIKDEIDADCCKVEVEESPGEVATYDE 145


>UniRef50_C1ZCI0 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Planctomycetaceae
           RepID=C1ZCI0_PLALI
          Length = 161

 Score = 75.5 bits (185), Expect = 5e-13,   Method: Composition-based stats.
 Identities = 32/135 (23%), Positives = 48/135 (35%), Gaps = 38/135 (28%)

Query: 1   MMSTTLFKDFT---FEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE 57
           M    +        F AAH +     G+ C RLHGH++ V +E+TG       ++ DF  
Sbjct: 1   MPEFRVRVTKDHLVFSAAHFITF--NGNICERLHGHNWRVAVELTGP-LDENSYVFDFIA 57

Query: 58  LKAAFKPTYERLDHHYLN--------------------------------DIPGLENPTS 85
           L+ A +     LDH  L                                  +  + N T+
Sbjct: 58  LRDATQKLVHELDHKVLLPLQHPTIKVEVGPKEVEAKFEDRRWVFPLEDCALLPIANTTA 117

Query: 86  EVLAKWIWDQVKPVV 100
           E+LA W    +  VV
Sbjct: 118 ELLADWFAKHLCEVV 132


>UniRef50_Q6L053 6-pyruvoyltetrahydrobiopterin synthase n=1 Tax=Picrophilus torridus
           RepID=Q6L053_PICTO
          Length = 144

 Score = 75.1 bits (184), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 35/137 (25%), Positives = 55/137 (40%), Gaps = 30/137 (21%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPH---TGWIIDFAELKAAFK 63
            +   + AAH +P  P   KCGRLHGH +++ + +  + +      G+ ID+ ++K A K
Sbjct: 9   TRGLHWSAAHIIPGHP---KCGRLHGHDYILNIRLYFDENNSLKTRGYEIDYGDIKRAAK 65

Query: 64  PTYERLDHHYL--------NDIPGLENPT---------------SEVLAKWIWDQVKPVV 100
              ER+DHH++        N      N T               SE LA +I  ++    
Sbjct: 66  AIIERMDHHFMVPEDAIEDNGKIHYNNITVSADQVCRIPVPVVSSENLAIYIKSELNRYF 125

Query: 101 PL-LSAVMVKETCTAGC 116
                   V E    G 
Sbjct: 126 SEYKIECGVFEGEGQGA 142


>UniRef50_Q7UMI8 Putative uncharacterized protein n=2 Tax=Planctomycetaceae
           RepID=Q7UMI8_RHOBA
          Length = 175

 Score = 75.1 bits (184), Expect = 6e-13,   Method: Composition-based stats.
 Identities = 33/146 (22%), Positives = 52/146 (35%), Gaps = 42/146 (28%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
            F F AAH +     G  C R+HGH++ VR+ + G       +++DF  L+ A     + 
Sbjct: 24  QFIFSAAHFITF--AGDICERIHGHNYGVRVSVEGP-LDENRYVVDFIALRDAVLKQTQA 80

Query: 69  LDHHYL-----------------------------ND---IPGLENPTSEVLAKWIWDQV 96
           LDHH +                             N+   I  + N T+E +A+ I + V
Sbjct: 81  LDHHVILPRDHKEILVTQDETETTARFRERRWVFPNEDCIIMPVINTTAEEIARVIAENV 140

Query: 97  KPVVPLLS-------AVMVKETCTAG 115
           +               V V E     
Sbjct: 141 REQTKEQFGKALSSIEVAVDENAGQW 166


>UniRef50_A9HRF7 Putative uncharacterized protein n=3 Tax=Acetobacteraceae
           RepID=A9HRF7_GLUDA
          Length = 181

 Score = 75.1 bits (184), Expect = 7e-13,   Method: Composition-based stats.
 Identities = 29/151 (19%), Positives = 50/151 (33%), Gaps = 32/151 (21%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT----GEVDPHTGWIIDFAE 57
               L     F   HRL        C   HGH+  V + +       +D     ++ F  
Sbjct: 6   PMLDLVFTRRFSMGHRLI-HDASESCALPHGHNEFVTVRLRPTAPRPLDGAGNMVVSFQR 64

Query: 58  LKAAFKP-TYERLDHHY-LNDIPGL-------------------ENPTSEVLAKWIWDQV 96
            K  +     ERLDH   L +   L                    +PT+E+ A  +  ++
Sbjct: 65  AKGRWHRFVDERLDHALQLAEDDPLLAWFRANEPERARRIVVTPGDPTTELTACLMMAKL 124

Query: 97  KPVV------PLLSAVMVKETCTAGCIYRGE 121
             ++         + + ++ET T    + GE
Sbjct: 125 NALLDADGGVLRCAGITLQETPTNTVEFEGE 155


>UniRef50_A9G7Q3 6-pyruvoyltetrahydropterin synthase n=1 Tax=Sorangium cellulosum
           'So ce 56' RepID=A9G7Q3_SORC5
          Length = 106

 Score = 74.8 bits (183), Expect = 9e-13,   Method: Composition-based stats.
 Identities = 19/105 (18%), Positives = 45/105 (42%), Gaps = 13/105 (12%)

Query: 30  LHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDIPGL--ENPTSEV 87
           +HG ++ V +EI  +       ++D   L A+ +   + +D+  L++ P       T+E 
Sbjct: 1   MHGATYSVEIEIRAKALGPHHVVMDIGALHASLRRVLDTIDYTNLDEHPAFPGRTSTTER 60

Query: 88  LAKWIWDQVKPVVPLL-----------SAVMVKETCTAGCIYRGE 121
           +A+ +   +   +  L             V+V+E+ +A   +  +
Sbjct: 61  VAEHVAGLLAEEIARLPAAEAPLPGSTLRVLVRESPSAYAGFERD 105


>UniRef50_UPI0001AF6FD6 hypothetical protein MkanA1_23688 n=1 Tax=Mycobacterium kansasii
           ATCC 12478 RepID=UPI0001AF6FD6
          Length = 146

 Score = 74.4 bits (182), Expect = 1e-12,   Method: Composition-based stats.
 Identities = 35/144 (24%), Positives = 57/144 (39%), Gaps = 28/144 (19%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT-GEVDPHTGWIIDFAELKA 60
           MS T+ K F F+A HR        K   +HGH++ +RL +  G+       + D  EL  
Sbjct: 1   MSHTIEKTFRFDAGHRSLGFNYK-KEETIHGHTWQLRLILEYGDQLDDMKTVFDTNELAV 59

Query: 61  AFKPTYERLDHHYL--NDIPGLE--------------------NPTSEVLAKWIWDQVKP 98
             +P    LDH ++  +  P  +                    NPT E L + I+++V  
Sbjct: 60  IVEPIISDLDHSFIIWDQDPIYDDFLKVCELADVADKVYTVDFNPTIEGLVEHIYERVNS 119

Query: 99  VVP----LLSAVMVKETCTAGCIY 118
            +     +L  V ++   T    Y
Sbjct: 120 QLRLSGCVLRRVELQCASTLKASY 143


>UniRef50_UPI0001AF6FD4 hypothetical protein MkanA1_23678 n=2 Tax=Mycobacterium kansasii
           ATCC 12478 RepID=UPI0001AF6FD4
          Length = 165

 Score = 73.6 bits (180), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 33/163 (20%), Positives = 57/163 (34%), Gaps = 43/163 (26%)

Query: 2   MSTTLFKDFTFEAAHRLPHVP---------------EGHKCGRLHGHSFMVRLEITGEVD 46
           M  T+ + F  E  HR                      +KC  +HGH+  V + + G+  
Sbjct: 1   MPYTIKQTFRVEIGHRTWSHHMPTSRGGSEFYTPDLIANKCANIHGHTIFVSVTLVGDSL 60

Query: 47  PHTGWIIDFAELKAAFKPTYERLDHHYLND-IPGLEN-------------------PTSE 86
               +++D   L+ AF+P  +  D  ++ D    L                     PT E
Sbjct: 61  DEQYFLLDTDLLEQAFRPILDEFDFAFVVDRHDPLYEDIAAVVHKGGLKLCTVDFSPTFE 120

Query: 87  VLAKWIWDQVKPVVPLL---SAVMVKETC-----TAGCIYRGE 121
            L +  +D+++ V+        + +KE       T    Y GE
Sbjct: 121 GLVRHFYDRLQAVIAEKGLADQLRIKEMKVLGELTVEATYSGE 163


>UniRef50_C5SEY8 Putative uncharacterized protein n=1 Tax=Asticcacaulis excentricus
           CB 48 RepID=C5SEY8_9CAUL
          Length = 185

 Score = 73.2 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 29/148 (19%), Positives = 50/148 (33%), Gaps = 35/148 (23%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDP-----HTGWIIDFA 56
           M     +   F  AHRL       KC   HGH+  VR+ +  +         + +   F 
Sbjct: 1   MQIQFTRR--FSMAHRLR-ADRSSKCATPHGHNEFVRVSLKAKSPDTVKWGQSNYAQSFD 57

Query: 57  ELKAAFKPTYER-LDHHY-LNDIPGL-------------------ENPTSEVLAKWIWDQ 95
            LK  +    +  LDH + L     L                    +PT+E +A  ++ +
Sbjct: 58  ALKRDWHRFVDEALDHAFQLGADDPLIGFFQAHEPDLLPRLLIIPGDPTTEAVALALYHK 117

Query: 96  VKPVVP------LLSAVMVKETCTAGCI 117
           +  ++             ++ET T   I
Sbjct: 118 LNAILSAQVPDFECVRFEIEETPTNTVI 145


>UniRef50_D1W1T6 Conserved domain protein (Fragment) n=4 Tax=Bacteria
          RepID=D1W1T6_9BACT
          Length = 70

 Score = 73.2 bits (179), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 22/74 (29%), Positives = 36/74 (48%), Gaps = 5/74 (6%)

Query: 2  MSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLE-ITGEVDPHTGWIIDFAELKA 60
          M   + K     AAHRL  +    KC  LHGH++++ +     +     G + DF  +K 
Sbjct: 1  MIYCVSKRMEISAAHRL-SLSYESKCQCLHGHNWIITVYLFKKDKLNGDGMVFDFTHIK- 58

Query: 61 AFKPTYERLDHHYL 74
            K  +++LDH Y+
Sbjct: 59 --KAIHDQLDHAYI 70


>UniRef50_B5I9Q5 6-pyruvoyl tetrahydrobiopterin synthase n=2 Tax=Aciduliprofundum
           boonei T469 RepID=B5I9Q5_9EURY
          Length = 160

 Score = 72.1 bits (176), Expect = 5e-12,   Method: Composition-based stats.
 Identities = 40/156 (25%), Positives = 52/156 (33%), Gaps = 45/156 (28%)

Query: 2   MSTTL---FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAEL 58
           M   +        F A+H +P     HKC RLHGH + VRL I GE   H   + DF EL
Sbjct: 1   MLLEIDGWKVGLKFSASHFIPSH---HKCSRLHGHDYGVRLRIFGETKDH--ILYDFVEL 55

Query: 59  KAAFKPTYERLDHHYL--------------------------------NDIPGLENPTSE 86
           K   +   E LDH  L                                  I  +   T+E
Sbjct: 56  KNEVRSLCEELDHKLLIPKSKKYIRHHIKDDRIYVSFEDKHYVFPKGDVTIIPVNLITAE 115

Query: 87  VLAKWIWDQVKPVVPLLSAVM-----VKETCTAGCI 117
            LA++   +V   +     V      V E    G  
Sbjct: 116 ELARYFSKKVLERIRFPENVKGIEICVDEGPGQGAC 151


>UniRef50_Q1WTR4 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Lactobacillus
           salivarius RepID=Q1WTR4_LACS1
          Length = 122

 Score = 71.7 bits (175), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 21/120 (17%), Positives = 49/120 (40%), Gaps = 13/120 (10%)

Query: 1   MMSTTLFK-DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELK 59
           M     ++  F   A H +    +  +    H H++ +  ++  +   H    I F +++
Sbjct: 1   MGKIYSYRLKFYLNATHAMRWSDQIGEE---HPHTWEIICQVMKKEQNH---FIRFNDIE 54

Query: 60  AAFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCT 113
              +   E L + +LN +   +  NP+ E L  + +D++   +      L  + + E+ T
Sbjct: 55  DQIQKIIEPLQNQFLNTLAPFDKTNPSLENLGDYFFDEINLQLHEINCYLHQLEIGESPT 114


>UniRef50_C7XH17 6-pyruvoyl-tetrahydropterin synthase n=2 Tax=Lactobacillus
           crispatus RepID=C7XH17_9LACO
          Length = 122

 Score = 71.7 bits (175), Expect = 7e-12,   Method: Composition-based stats.
 Identities = 19/108 (17%), Positives = 44/108 (40%), Gaps = 13/108 (12%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
              A+H +       +    H H++ +R         + G +I F E++       ++ +
Sbjct: 13  YLNASHAIRWSKGIGQA---HSHTYEIRYSFH----INNGKLIRFNEIENKIAEIIKKFN 65

Query: 71  HHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETC 112
           + +LN++      NPT E L  +++++    +      L  + V E+ 
Sbjct: 66  NQFLNEVEPFTKVNPTLENLTDYLFNRFGEELNKLNCSLDEISVSESP 113


>UniRef50_C7JGU4 Putative uncharacterized protein n=8 Tax=Acetobacter pasteurianus
           RepID=C7JGU4_ACEP3
          Length = 182

 Score = 71.3 bits (174), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 26/151 (17%), Positives = 49/151 (32%), Gaps = 34/151 (22%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEIT----GEVDPHTGWIIDFA 56
           M      +   F   HRL        C   HGH+  V + +       +D      + F 
Sbjct: 1   MPDLVFTRR--FSMGHRLI-HGASESCALPHGHNEFVTVRLKPTSFAPLDGKGNMPVSFQ 57

Query: 57  ELKAAFKPTYER-LDHHY-LNDIPGL-------------------ENPTSEVLAKWIWDQ 95
           + K+ +    +  LDH   L +   L                    +PT+E++   +  +
Sbjct: 58  KAKSTWHRFVDEKLDHALQLAEDDPLLAWFQANEPARAARIVITPGDPTTELMVCLLMAK 117

Query: 96  VKPVVPL------LSAVMVKETCTAGCIYRG 120
           +   +         S + ++ET T    + G
Sbjct: 118 INAFLAAEGGVLQCSELSIQETPTNTVSFSG 148


>UniRef50_Q6MLN9 6-pyruvoyltetrahydropterin synthase n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLN9_BDEBA
          Length = 129

 Score = 70.9 bits (173), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 26/131 (19%), Positives = 46/131 (35%), Gaps = 18/131 (13%)

Query: 4   TTLFKDFTFEAAHRL--------PHVPEGHKC--GRLHGHSFMVRLEITGEVDPHTGWII 53
             +     F AAH           +     +C     HGH++M+     G    +  W  
Sbjct: 1   MIITLKSPFSAAHFYAQPQWDEHKNRETFGRCYTQYGHGHNYMLE---AGFHCQNDSWKQ 57

Query: 54  DFAELKAAFKPTYERLDHHYLND-IPGLEN--PTSEVLAKWIWDQVKPVVP--LLSAVMV 108
                ++        LDH +LN  IP  +   PT+E +  +  +++K  V    +S + +
Sbjct: 58  QQQHYQSVLNNLTAVLDHEHLNFVIPEFKTNIPTTENICLYFLEKLKSQVKSEEISYLRL 117

Query: 109 KETCTAGCIYR 119
            E        R
Sbjct: 118 YEMDNIWTEIR 128


>UniRef50_Q19Z82 Gp4 n=2 Tax=unclassified Siphoviridae RepID=Q19Z82_9CAUD
          Length = 143

 Score = 70.1 bits (171), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 26/91 (28%), Positives = 38/91 (41%), Gaps = 6/91 (6%)

Query: 6  LFKDFTFEAAHRLPHV-PEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFK- 63
          L     F A HR+P +   G KC   HGH+F V           + +  +FAE K   + 
Sbjct: 7  LTVKHHFSAGHRIPGLAGAGGKCATPHGHTFGVEWTFQVSSLDASEF--EFAEAKKLLRG 64

Query: 64 PTYERLDHHYLN--DIPGLENPTSEVLAKWI 92
             E LDH +L   D   + N  ++   K+ 
Sbjct: 65 WVDEHLDHGFLVAPDDLLVRNTFADNGWKYF 95


>UniRef50_Q58668 Putative 6-carboxy-5,6,7,8-tetrahydropterin synthase n=4
           Tax=Methanocaldococcus RepID=QUED_METJA
          Length = 163

 Score = 70.1 bits (171), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 31/148 (20%), Positives = 53/148 (35%), Gaps = 42/148 (28%)

Query: 11  TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLD 70
            F +AH +   P    CG +HGHS+ V +++ GE      ++ DF  +K   K   + LD
Sbjct: 13  RFSSAHIVFGHPT---CGVIHGHSYYVDVKLYGERAGDFKFVCDFKIIKKIVKEICDELD 69

Query: 71  HHYL----------------------ND----------IPGLENPTSEVLAKWIWDQVKP 98
           H  +                      N           +  + + T+E LA +  +++  
Sbjct: 70  HKLILPKNHEHVYYELRDKTLYFKYENKEYSIPVEDVILLPIPSTTAEDLAIYFANEIAD 129

Query: 99  VVPLL-------SAVMVKETCTAGCIYR 119
            +  L         V + E    G  YR
Sbjct: 130 RLKNLGFSNINWIEVSINEGIGQGACYR 157


>UniRef50_P80081 6-pyruvoyl tetrahydrobiopterin synthase (Fragments) n=1 Tax=Salmo
           salar RepID=PTPS_SALSA
          Length = 103

 Score = 69.8 bits (170), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 25/120 (20%), Positives = 42/120 (35%), Gaps = 35/120 (29%)

Query: 5   TLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKP 64
            + +  +F A+HRL                                 +++   +K   + 
Sbjct: 16  YITRVQSFCASHRLHSPT----------------------------LVMNITNIKEHIEE 47

Query: 65  TYERLDHHYLN-DIPGLENPTSEVLAKWIWDQVKPVVPL--LSAVMVKETCTAGCIYRGE 121
               LDH  L+ D+P   N     +A +I D +   +P   L  V + ET     +YRGE
Sbjct: 48  VI-PLDHKNLDKDVPYFANV---NVAVYIXDNMVKQLPANLLYEVKIHETDKNIVVYRGE 103


>UniRef50_Q97FZ8 6-pyruvoyl-tetrahydropterin synthase related protein n=2
           Tax=Clostridium acetobutylicum RepID=Q97FZ8_CLOAB
          Length = 159

 Score = 69.4 bits (169), Expect = 3e-11,   Method: Composition-based stats.
 Identities = 24/111 (21%), Positives = 49/111 (44%), Gaps = 13/111 (11%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
            F   A+H +       +    H H++ + +     +  HTG++I F +++   +   ++
Sbjct: 9   KFYLNASHSIFINGVLGEE---HPHTWEITIY---TIKFHTGFVI-FNDVERYVEKYMKK 61

Query: 69  LDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPL----LSAVMVKETCT 113
               Y+N I      NPT E + K+  D +K ++      L ++ + ET T
Sbjct: 62  YQDSYINRIEPFITLNPTLENMCKFFKDNMKALLAEKGWILLSIEISETPT 112


>UniRef50_B4RFN3 6-pyruvoyl tetrahydrobiopterin synthase n=3 Tax=Alphaproteobacteria
           RepID=B4RFN3_PHEZH
          Length = 170

 Score = 69.0 bits (168), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 28/131 (21%), Positives = 44/131 (33%), Gaps = 28/131 (21%)

Query: 17  RLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAE--LKAAFKPTYERLDHHYL 74
            L        C  LHG+S   R     E     GW++DF         +  +   DH  L
Sbjct: 18  ALRQWAADSHCALLHGYSLGFRFTFAAEQLDRRGWVVDFGSGGFGKIREWLHGTFDHALL 77

Query: 75  --NDIPG-----------------LENPTSEVLAKWIWDQVKPVVPL-------LSAVMV 108
              D PG                 +   + E LA+++++  +P+V         ++ V  
Sbjct: 78  VAEDDPGRPELARLADLGLARVQVVPGTSCEALARFVFEAAQPMVAAATQGRCWIAEVEC 137

Query: 109 KETCTAGCIYR 119
            E      IYR
Sbjct: 138 FEHGANSAIYR 148


>UniRef50_C2FQF2 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Lactobacillus
           plantarum RepID=C2FQF2_LACPL
          Length = 122

 Score = 69.0 bits (168), Expect = 4e-11,   Method: Composition-based stats.
 Identities = 19/107 (17%), Positives = 44/107 (41%), Gaps = 14/107 (13%)

Query: 13  EAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHH 72
            A+H +       K    H H++ +  E+          +  F +++       + L   
Sbjct: 15  NASHAVRWATGSGK---KHTHTWEIVCELHT----VDAMVA-FYDIEKNLHQALDELSGK 66

Query: 73  YLNDIPGLE--NPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCT 113
           +LND+P  +  NPT E + ++++ ++   +      L  + V ++ T
Sbjct: 67  FLNDLPEFKTVNPTVENVTEYLFTKIDKTLRDNGAQLLRIEVSDSPT 113


>UniRef50_D1B474 Putative uncharacterized protein n=3 Tax=Campylobacterales
           RepID=D1B474_SULD5
          Length = 180

 Score = 69.0 bits (168), Expect = 5e-11,   Method: Composition-based stats.
 Identities = 31/174 (17%), Positives = 51/174 (29%), Gaps = 61/174 (35%)

Query: 2   MSTTLFKDFTFEAAHRLPHVPEGHK--------CGRLHGHSFMVRLEITGEVDPHTGWII 53
           M   + K+F F   HR+       +        C  LHGH   + + +        G + 
Sbjct: 1   MLWQISKEFDFCYGHRVWSQQLDSEFSLTGCLACRHLHGHQGKIVVYLQSNEL-KNGMVT 59

Query: 54  DFAELKAAFKPTYERLDHHYLNDI---------PGLEN---------------------- 82
           DF  L    +     LDH ++ DI         P   +                      
Sbjct: 60  DFHHLNWFKQFLDATLDHKFIIDIHDPLFETLLPHFADKQNLLSHEAGYQTPDLSKVAHE 119

Query: 83  -----------------PTSEVLAKWIWDQVKPVVPLL----SAVMVKETCTAG 115
                            PTSE ++ W+ + ++  +  L    S V   ET  + 
Sbjct: 120 AMHLIEMYEGYIIVDFVPTSENISTWLLEIIQKKMSRLGVKVSHVEFLETPKSR 173


>UniRef50_C6KTB6 6-pyruvoyltetrahydropterin synthase n=6 Tax=Plasmodium
           RepID=C6KTB6_PLAF7
          Length = 173

 Score = 68.2 bits (166), Expect = 7e-11,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 59/150 (39%), Gaps = 46/150 (30%)

Query: 10  FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERL 69
           F+F  AH + +         LHGH++ V L++ G V    G++IDF+ LK   K    +L
Sbjct: 23  FSFNCAHFIAY---NGFRETLHGHNYNVSLKVRGYV-RDDGYVIDFSILKEKVKKVCNKL 78

Query: 70  DHHYL----NDIPGLEN-----------------------------PTSEVLAKWIWDQV 96
           DHH++    +D+   EN                              ++E + ++I +Q+
Sbjct: 79  DHHFILPIYSDVLKFENVKNNIKIICEDNSEYSFPERDCIKLPIKHSSTEEIGQYILNQL 138

Query: 97  KPVVPLLS---------AVMVKETCTAGCI 117
              + +            + V E+ T   I
Sbjct: 139 IEEMDVSLLKSRHIHYIEISVSESPTQKAI 168


>UniRef50_A0RWH6 6-pyruvoyl-tetrahydropterin synthase n=3 Tax=Archaea
           RepID=A0RWH6_CENSY
          Length = 270

 Score = 67.8 bits (165), Expect = 9e-11,   Method: Composition-based stats.
 Identities = 24/67 (35%), Positives = 35/67 (52%), Gaps = 5/67 (7%)

Query: 8   KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
           + FTF+ AH LP V    KC  LHGH+  V +E+ G++    G ++DF + K   K    
Sbjct: 123 QSFTFDYAHVLPLVD---KCSVLHGHTSSVMVELAGQM--KDGMLVDFGKAKGIIKQAIS 177

Query: 68  RLDHHYL 74
             DH + 
Sbjct: 178 SFDHKFF 184


>UniRef50_Q6MLZ0 6-pyruvoyl-tetrahydropterin synthase, putative n=1 Tax=Bdellovibrio
           bacteriovorus RepID=Q6MLZ0_BDEBA
          Length = 159

 Score = 67.8 bits (165), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 50/150 (33%), Gaps = 41/150 (27%)

Query: 7   FKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITG---EVDPHTGWIIDFAELKAAFK 63
            ++F F AAH L          RLHGH++ V+++I     E     G+ +DF   K   K
Sbjct: 5   KQNFKFSAAHFLIFDET--HAERLHGHNYQVKVDIKTPSEEELHSDGYFLDFNVFKKYIK 62

Query: 64  PTYERLDHHYL------------------------------NDIPGLE--NPTSEV---- 87
              ++ D   L                              N++  L   N + E     
Sbjct: 63  ARLDQWDEMVLLPEKQKDMKFKKNGPSLEVTFRERFYAFPANEVTLLSVTNTSVEQLSRL 122

Query: 88  LAKWIWDQVKPVVPLLSAVMVKETCTAGCI 117
           LA+  + + K        V V ET   G  
Sbjct: 123 LAEEFFAEFKKYGVKSVRVYVAETAGQGAS 152


>UniRef50_A8SSX5 Putative uncharacterized protein n=2 Tax=Clostridiales
           RepID=A8SSX5_9FIRM
          Length = 152

 Score = 66.3 bits (161), Expect = 3e-10,   Method: Composition-based stats.
 Identities = 21/119 (17%), Positives = 46/119 (38%), Gaps = 14/119 (11%)

Query: 2   MSTTLFK-DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    +K  F   A H    + +    G +H H++ + + +    D      + F  L+ 
Sbjct: 1   MRFRQYKFKFYLNARH---GIYKNGVLGEVHPHTWEIVINVVKGRDE----TVKFHHLEH 53

Query: 61  AFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVVPLLSAV----MVKETCT 113
             +    R     LN+I   +  NPT E + ++  D++  ++     +     + E+ +
Sbjct: 54  RVEELLNRYQDKTLNEIAPFDMINPTLENMCEYFKDELTEILNRNGWIFLMMEMSESPS 112


>UniRef50_B7FTA7 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FTA7_PHATR
          Length = 173

 Score = 65.5 bits (159), Expect = 4e-10,   Method: Composition-based stats.
 Identities = 34/126 (26%), Positives = 54/126 (42%), Gaps = 17/126 (13%)

Query: 4   TTLFKD-FTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVD-PHTGWIIDFAELKAA 61
             + KD F F AAH +          RLHGH++ + + + G       G++IDF  +K  
Sbjct: 10  VYVSKDTFKFNAAHFVAFQGYR---ERLHGHNYRIGVRLLGRRQIGADGYLIDFGCVKDV 66

Query: 62  FKPTYERLDHHYL----NDIPGLENPTSEVLAKWI--WDQVKPVVPLLSAVMV---KETC 112
            K   +R++ H+L    +D+  +   T+E  +  I   D    V P    VM+     T 
Sbjct: 67  CKKVCKRINEHFLCPVHSDVLKI---TTENESVRIECADGTYFVFPAADCVMLPIFHATA 123

Query: 113 TAGCIY 118
               IY
Sbjct: 124 EELAIY 129


>UniRef50_A9VWK7 Putative uncharacterized protein n=3 Tax=Methylobacterium
           RepID=A9VWK7_METEP
          Length = 161

 Score = 64.7 bits (157), Expect = 8e-10,   Method: Composition-based stats.
 Identities = 24/126 (19%), Positives = 39/126 (30%), Gaps = 27/126 (21%)

Query: 18  LPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYERLDHHYLNDI 77
                    C  LHG++  V LE   +      W++DF  LK   +   +  DH  L   
Sbjct: 32  FRQWRSPSHCRFLHGYALAVHLEFEADDLDARSWVMDFGSLKPVRQWLEQTFDHKTLVAA 91

Query: 78  PG-------------------LENPTSEVLAKWIWDQVKPVVP--------LLSAVMVKE 110
                                L + + E  A+ I+  V+  +          L+ V V+E
Sbjct: 92  DDPLLSEMRAMDEVGLIQLVVLPHVSCEAFAEHIYSWVRGWLAQQNLSPRIRLAEVHVRE 151

Query: 111 TCTAGC 116
                 
Sbjct: 152 HGANAA 157


>UniRef50_B9Z9U9 6-pyruvoyl tetrahydropterin synthase n=2 Tax=Halobacteriaceae
          RepID=B9Z9U9_NATMA
          Length = 159

 Score = 64.7 bits (157), Expect = 9e-10,   Method: Composition-based stats.
 Identities = 17/67 (25%), Positives = 28/67 (41%), Gaps = 7/67 (10%)

Query: 8  KDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYE 67
          +       HR+ H     KC R HGH++ V + + G      GW+ D  ++        +
Sbjct: 33 RPIRISTGHRILHHD--GKCARPHGHNYEVSVTVEG-TLTEEGWVADKGDI----TAVID 85

Query: 68 RLDHHYL 74
            DH +L
Sbjct: 86 EWDHKFL 92


>UniRef50_A7VEN5 Putative uncharacterized protein n=1 Tax=Clostridium sp. L2-50
           RepID=A7VEN5_9CLOT
          Length = 146

 Score = 64.0 bits (155), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 23/104 (22%), Positives = 43/104 (41%), Gaps = 11/104 (10%)

Query: 1   MMSTTLFKDFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M+       + F A+H            + H H+F + L I      ++G  +DF  L  
Sbjct: 1   MIDYY-KCQYHFNASHSF-----DGNKEQAHSHTFTMILYIR----NYSGRDMDFKRLDR 50

Query: 61  AFKPTYERLDHHYLNDIPGLE-NPTSEVLAKWIWDQVKPVVPLL 103
             +    R +  YLN++P    N + E +  + ++Q+K  +  L
Sbjct: 51  MIEIFLGRYEGMYLNELPCFAGNASIEAIGDYFYEQLKIKLSEL 94


>UniRef50_Q4A0G7 Putative 6-pyruvoyl tetrahydrobiopterin synthase n=1
           Tax=Staphylococcus saprophyticus subsp. saprophyticus
           ATCC 15305 RepID=Q4A0G7_STAS1
          Length = 142

 Score = 63.6 bits (154), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 5/86 (5%)

Query: 34  SFMVRLEITGEVDPHTGWIIDFAELKAAF-KPTYERLDHHYLNDIPGLENPTSEVLAKWI 92
           ++   +EI   +    G  +DF E+   + +     +D   +N+     N T+E +A WI
Sbjct: 48  TYKFNIEILSSI-DAYGLAMDFNEVDKLYEREIAPYIDGQLVNETLPEMNTTAENIAIWI 106

Query: 93  WDQVKPVVPL---LSAVMVKETCTAG 115
           W Q    +P    L  +   ET T G
Sbjct: 107 WHQFNKHLPENNSLQKLEFFETDTQG 132


>UniRef50_Q97G44 6-pyruvoyl-tetrahydropterin synthase related protein n=1
           Tax=Clostridium acetobutylicum RepID=Q97G44_CLOAB
          Length = 118

 Score = 63.6 bits (154), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 20/111 (18%), Positives = 42/111 (37%), Gaps = 13/111 (11%)

Query: 9   DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAAFKPTYER 68
            F   A H         +   +H H++ + + +  + D    + I F E++   +     
Sbjct: 8   KFYLNARHV---AIIDGRASNIHPHTWELLINVGAKED----YTISFGEVEKEVQAYLAN 60

Query: 69  LDHHYLNDIPGLE--NPTSEVLAK----WIWDQVKPVVPLLSAVMVKETCT 113
            +  +LN+    +  NPT E + K    +I D +        ++ + E  T
Sbjct: 61  YEGSFLNEKEEFKDINPTMESIGKVLIPYIKDIISKKEMKFISMEISENPT 111


>UniRef50_Q97FZ3 6-pyruvoyl-tetrahydropterin synthase related domain; conserved
           membrane protein n=2 Tax=Clostridium acetobutylicum
           RepID=Q97FZ3_CLOAB
          Length = 1002

 Score = 63.2 bits (153), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 21/119 (17%), Positives = 49/119 (41%), Gaps = 14/119 (11%)

Query: 2   MSTTLFK-DFTFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKA 60
           M    +   F   A+H +      +K G +H H+FM+ ++I   +     ++  + +++ 
Sbjct: 1   MEFRGYVYKFKLNASHSVL---INNKRGNVHSHTFMIAIKIR--IADDEFFL--YNKIEK 53

Query: 61  AFKPTYERLDHHYLNDIPGLE--NPTSEVLAKWIWDQVKPVV----PLLSAVMVKETCT 113
                  R +   LN I   +   PT E +  +++ ++  V       L+ + + E  +
Sbjct: 54  LVNDYLRRYEAQELNKISPFDKLEPTLENIGNFLFKEITKVFNEKKVELTRLEISENPS 112


>UniRef50_UPI0001B4C1FC hypothetical protein ShygA5_47370 n=1 Tax=Streptomyces
           hygroscopicus ATCC 53653 RepID=UPI0001B4C1FC
          Length = 174

 Score = 61.3 bits (148), Expect = 9e-09,   Method: Composition-based stats.
 Identities = 31/121 (25%), Positives = 49/121 (40%), Gaps = 23/121 (19%)

Query: 3   STTLFKDFT-FEAAHRLPHVPEGHKCGRLHGHSFMVRLEI-TGEVDPHTGWIIDFAELKA 60
             ++ K F      HR      G KC  LHG+     +E   GE++P TG++IDF +LK 
Sbjct: 24  RFSVTKLFDDLPCTHR--SWAHGGKCSFLHGYERSFEIEFGCGELEPKTGFVIDFGDLKE 81

Query: 61  AFKPTYERLDHHYL-------------------NDIPGLENPTSEVLAKWIWDQVKPVVP 101
                  + DH  L                    D+  +++   E  A+W+ D+V  +V 
Sbjct: 82  VRALLQAQFDHTTLIAADDPHRELFEDLGRSGVIDLRIMDHTGMEGAAEWVHDRVAQLVG 141

Query: 102 L 102
            
Sbjct: 142 E 142


>UniRef50_C5SCP3 Putative uncharacterized protein n=1 Tax=Allochromatium vinosum
          DSM 180 RepID=C5SCP3_CHRVI
          Length = 174

 Score = 59.7 bits (144), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 26/82 (31%), Positives = 34/82 (41%), Gaps = 7/82 (8%)

Query: 3  STTLFKDF-TFEAAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTGWIIDFAELKAA 61
             + KD+  F A H             LHGH+F VR  +T +V    G   D+  LK A
Sbjct: 14 RIEISKDYLNFSAGHFTLFSATER--ENLHGHNFRVRCAVTAQV-GEGGLTFDYVILKRA 70

Query: 62 FKPTYERLDHHYLNDIPGLENP 83
           K   + LD   L     LE+P
Sbjct: 71 LKELCDALDERML---LPLESP 89


>UniRef50_D0XQU8 Putative uncharacterized protein n=1 Tax=Brevundimonas
           subvibrioides ATCC 15264 RepID=D0XQU8_9CAUL
          Length = 164

 Score = 59.7 bits (144), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 25/131 (19%), Positives = 46/131 (35%), Gaps = 31/131 (23%)

Query: 14  AAHRLPHVPEGHKCGRLHGHSFMVRLEITGEVDPHTG---WIIDFAELKAAFKPTYE-RL 69
            AHRL     G +C   HGH+  V + +  +     G   ++  F  LK  +    +  +
Sbjct: 1   MAHRLL-ADAGSRCAVPHGHNEFVTVTLATDAAIDFGGSNYVASFETLKKRWHGFIDGAV 59

Query: 70  DHHY-------------------LNDIPGLE-NPTSEVLAKWIWDQVKPVVP------LL 103
           DH +                   L  +   E +PT+E  A  +  ++   +         
Sbjct: 60  DHAFQVGSADPLLDWFRTHEPHRLGQLMVFEGDPTTEAFAIALRRKLDAFLADDGSPYRC 119

Query: 104 SAVMVKETCTA 114
             + ++ET T 
Sbjct: 120 VELALEETPTN 130


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.315    0.170    0.581 

Lambda     K      H
   0.267   0.0520    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 975,386,967
Number of Sequences: 3077464
Number of extensions: 46293182
Number of successful extensions: 110742
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 504
Number of HSP's successfully gapped in prelim test: 245
Number of HSP's that attempted gapping in prelim test: 108580
Number of HSP's gapped (non-prelim): 890
length of query: 121
length of database: 1,040,396,356
effective HSP length: 88
effective length of query: 33
effective length of database: 769,579,524
effective search space: 25396124292
effective search space used: 25396124292
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.2 bits)
S2: 88 (38.2 bits)
