Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	E	N	L	N	L	S	L	F	S	L	I	N	A	T	P	D	S	A	P	W	M	I	S	L	A	I	F	I	A	K	D	L	I	T	V	V	P	L	L	A	V	V	L	W	L	W	G	L	T	A	Q	R	Q	L	V	I	K	I
Secondary structure
SS confidence
Disorder		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	I	A	L	A	V	S	L	F	V	S	W	T	M	G	H	L	F	P	H	D	R	P	F	V	E	N	I	G	Y	N	F	L	H	H	A	A	D	D	S	F	P	S	D	H	G	T	V	I	F	T	F	A	L	A	F	L	C	W	H
Secondary structure
SS confidence
Disorder																																							?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	L	W	S	G	S	L	L	M	V	L	A	V	V	I	A	W	S	R	V	Y	L	G	V	H	W	P	L	D	M	L	G	G	L	L	A	G	M	I	G	C	L	S	A	Q	I	I	W	Q	A	M	G	H	K	L	Y	Q	R	L	Q
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.
Sequence		S	W	Y	R	V	C	F	A	L	P	I	R	K	G	W	V	R	D
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1d2t chain A Region: 3 - 165 Aligned: 162 Modelled: 163 Confidence: 99.8% Identity: 10% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Type 2 phosphatidic acid phosphatase, PAP2 Phyre2 PDB 2akc chain C Region: 3 - 161 Aligned: 158 Modelled: 159 Confidence: 99.8% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:class a nonspecific acid phosphatase phon; PDBTitle: crystal structure of tungstate complex of the phon protein2 from s. typhimurium Phyre2 PDB 1qi9 chain A Region: 79 - 162 Aligned: 84 Modelled: 84 Confidence: 98.3% Identity: 27% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Haloperoxidase (bromoperoxidase) Phyre2 PDB 1vns chain A Region: 55 - 158 Aligned: 104 Modelled: 104 Confidence: 98.0% Identity: 26% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Chloroperoxidase Phyre2 PDB 1vng chain A Region: 55 - 158 Aligned: 104 Modelled: 104 Confidence: 97.9% Identity: 25% PDB header:haloperoxidase Chain: A: PDB Molecule:vanadium chloroperoxidase; PDBTitle: chloroperoxidase from the fungus curvularia inaequalis:2 mutant h404a Phyre2 PDB 1up8 chain A Region: 79 - 162 Aligned: 84 Modelled: 84 Confidence: 97.5% Identity: 21% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Haloperoxidase (bromoperoxidase) Phyre2 PDB 1qhb chain A Region: 95 - 162 Aligned: 68 Modelled: 68 Confidence: 97.3% Identity: 24% Fold: Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily: Acid phosphatase/Vanadium-dependent haloperoxidase Family: Haloperoxidase (bromoperoxidase) Phyre2 PDB 2knc chain B Region: 150 - 178 Aligned: 29 Modelled: 29 Confidence: 13.7% Identity: 10% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2cg4 chain B Region: 1 - 15 Aligned: 15 Modelled: 15 Confidence: 8.6% Identity: 13% PDB header:transcription Chain: B: PDB Molecule:regulatory protein asnc; PDBTitle: structure of e.coli asnc Phyre2 PDB 1eh9 chain A domain 2 Region: 97 - 103 Aligned: 7 Modelled: 7 Confidence: 8.1% Identity: 43% Fold: Glycosyl hydrolase domain Superfamily: Glycosyl hydrolase domain Family: alpha-Amylases, C-terminal beta-sheet domain Phyre2 PDB 2l34 chain A Region: 150 - 175 Aligned: 26 Modelled: 25 Confidence: 7.7% Identity: 15% PDB header:protein binding Chain: A: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer Phyre2 PDB 2l34 chain B Region: 150 - 175 Aligned: 26 Modelled: 25 Confidence: 7.7% Identity: 15% PDB header:protein binding Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer Phyre2 PDB 2cg4 chain A domain 1 Region: 1 - 20 Aligned: 20 Modelled: 20 Confidence: 6.5% Identity: 15% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: Lrp/AsnC-like transcriptional regulator N-terminal domain Phyre2 PDB 1dsv chain A Region: 143 - 149 Aligned: 7 Modelled: 7 Confidence: 5.6% Identity: 43% Fold: Retrovirus zinc finger-like domains Superfamily: Retrovirus zinc finger-like domains Family: Retrovirus zinc finger-like domains Phyre2 PDB 2r4q chain A domain 1 Region: 100 - 110 Aligned: 11 Modelled: 10 Confidence: 5.5% Identity: 18% Fold: Phosphotyrosine protein phosphatases I-like Superfamily: PTS system IIB component-like Family: PTS system, Fructose specific IIB subunit-like Phyre2 1 d1d2ta_ 2 c2akcC_ 3 d1qi9a_ 4 d1vnsa_ 5 c1vngA_ 6 d1up8a_ 7 d1qhba_ 8 c2kncB_ 9 c2cg4B_ 10 d1eh9a2 11 c2l34A_ 12 c2l34B_ 13 d2cg4a1 14 d1dsva_ 15 d2r4qa1

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1d2ta_ 99.8 10 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Type 2 phosphatidic acid phosphatase, PAP2 2 c2akcC_ 99.8 18 PDB header:hydrolase Chain: C: PDB Molecule:class a nonspecific acid phosphatase phon; PDBTitle: crystal structure of tungstate complex of the phon protein2 from s. typhimurium 3 d1qi9a_ 98.3 27 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Haloperoxidase (bromoperoxidase) 4 d1vnsa_ 98.0 26 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Chloroperoxidase 5 c1vngA_ 97.9 25 PDB header:haloperoxidase Chain: A: PDB Molecule:vanadium chloroperoxidase; PDBTitle: chloroperoxidase from the fungus curvularia inaequalis:2 mutant h404a 6 d1up8a_ 97.5 21 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Haloperoxidase (bromoperoxidase) 7 d1qhba_ 97.3 24 Fold:Acid phosphatase/Vanadium-dependent haloperoxidase Superfamily:Acid phosphatase/Vanadium-dependent haloperoxidase Family:Haloperoxidase (bromoperoxidase) 8 c2kncB_ 13.7 10 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 9 c2cg4B_ 8.6 13 PDB header:transcription Chain: B: PDB Molecule:regulatory protein asnc; PDBTitle: structure of e.coli asnc 10 d1eh9a2 8.1 43 Fold:Glycosyl hydrolase domain Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain 11 c2l34A_ 7.7 15 PDB header:protein binding Chain: A: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer 12 c2l34B_ 7.7 15 PDB header:protein binding Chain: B: PDB Molecule:tyro protein tyrosine kinase-binding protein; PDBTitle: structure of the dap12 transmembrane homodimer 13 d2cg4a1 6.5 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:Lrp/AsnC-like transcriptional regulator N-terminal domain 14 d1dsva_ 5.6 43 Fold:Retrovirus zinc finger-like domains Superfamily:Retrovirus zinc finger-like domains Family:Retrovirus zinc finger-like domains 15 d2r4qa1 5.5 18 Fold:Phosphotyrosine protein phosphatases I-like Superfamily:PTS system IIB component-like Family:PTS system, Fructose specific IIB subunit-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0