Phyre Home Retrieve Phyre Job Id
Emaill.a.kelley@imperial.ac.uk
DescriptionP75763
DateThu Jan 5 12:13:52 GMT 2012
Unique Job ID11055a693ff34ec0

Summary 

Top model
Image coloured by rainbow N → C terminus
Model (left) based on template c3orgB_
Top template information
PDB header:transport protein
Chain: B: PDB Molecule:cmclc;
PDBTitle: crystal structure of a eukaryotic clc transporter
Confidence and coverage
Confidence: 52.3% Coverage: 35%
168 residues ( 35% of your sequence) have been modelled with 52.3% confidence by the single highest scoring template.
You may wish to submit your sequence to Phyrealarm. This will automatically scan your sequence every week for new potential templates as they appear in the Phyre2 library.
Please note: You must be registered and logged in to use Phyrealarm.
3D viewing
Interactive 3D view in Jmol

Sequence analysis 

Secondary structure and disorder prediction 

   1........10.........20.........30.........40.........50.........60
Sequence  MNKKSLWKLILILAIPCIIGFMPAPAGLSELAWVLFGIYLAAIVGLVIKPFPEPVVLLIA
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   .........70.........80.........90.........100.........110.........120
Sequence  VAASMVVVGNLSDGAFKTTAVLSGYSSGTTWLVFSAFTLSAAFVTTGLGKRIAYLLIGKI
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   .........130.........140.........150.........160.........170.........180
Sequence  GNTTLGLGYVTVFLDLVLAPATPSNTARAGGIVLPIINSVAVALGSEPEKSPRRVGHYLM
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   .........190.........200.........210.........220.........230.........240
Sequence  MSIYMVTKTTSYMFFTAMAGNILALKMINDILHLQISWGGWALAAGLPGIIMLLVTPLVI
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   .........250.........260.........270.........280.........290.........300
Sequence  YTMYPPEIKKVDNKTIAKAGLAELGPMKIREKMLLGVFVLALLGWIFSKSLGVDESTVAI
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   .........310.........320.........330.........340.........350.........360
Sequence  VVMATMLLLGIVTWEDVVKNKGGWNTLIWYGGIIGLSSLLSKVKFFEWLAEVFKNNLAFD
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   .........370.........380.........390.........400.........410.........420
Sequence  GHGNVAFFVIIFLSIIVRYFFASGSAYIVAMLPVFAMLANVSGAPLMLTALALLFSNSYG
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   .........430.........440.........450.........460.........470.......
Sequence  GMVTHYGGAAGPVIFGVGYNDIKSWWLVGAVLTILTFLVHITLGVWWWNMLIGWNML
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Confidence Key
High(9)                    Low (0)
?Disordered
Alpha helix
Beta strand

Domain analysis 

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

RankAligned region

PDB 3org chain B

3D model

Region: 174 - 341
Aligned: 168
Modelled: 168
Confidence: 52.3%
Identity: 11%
PDB header:transport protein
Chain: B: PDB Molecule:cmclc;
PDBTitle: crystal structure of a eukaryotic clc transporter

Phyre2

PDB 1y5i chain C domain 1

3D model

Region: 217 - 342
Aligned: 126
Modelled: 126
Confidence: 27.9%
Identity: 10%
Fold: Heme-binding four-helical bundle
Superfamily: Respiratory nitrate reductase 1 gamma chain
Family: Respiratory nitrate reductase 1 gamma chain

Phyre2

PDB 1w8x chain P

3D model

Region: 1 - 21
Aligned: 21
Modelled: 21
Confidence: 24.6%
Identity: 24%
PDB header:virus
Chain: P: PDB Molecule:protein p16;
PDBTitle: structural analysis of prd1

Phyre2

PDB 2w8a chain C

3D model

Region: 125 - 266
Aligned: 118
Modelled: 124
Confidence: 13.1%
Identity: 9%
PDB header:membrane protein
Chain: C: PDB Molecule:glycine betaine transporter betp;
PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate

Phyre2

PDB 1ymg chain A

3D model

Region: 167 - 259
Aligned: 89
Modelled: 93
Confidence: 11.9%
Identity: 18%
PDB header:membrane protein
Chain: A: PDB Molecule:lens fiber major intrinsic protein;
PDBTitle: the channel architecture of aquaporin o at 2.2 angstrom resolution

Phyre2

PDB 1ymg chain A domain 1

3D model

Region: 167 - 259
Aligned: 89
Modelled: 93
Confidence: 11.9%
Identity: 18%
Fold: Aquaporin-like
Superfamily: Aquaporin-like
Family: Aquaporin-like

Phyre2

PDB 3d9s chain B

3D model

Region: 167 - 263
Aligned: 94
Modelled: 97
Confidence: 10.4%
Identity: 13%
PDB header:membrane protein
Chain: B: PDB Molecule:aquaporin-5;
PDBTitle: human aquaporin 5 (aqp5) - high resolution x-ray structure

Phyre2

PDB 1j4n chain A

3D model

Region: 167 - 256
Aligned: 87
Modelled: 90
Confidence: 9.2%
Identity: 11%
Fold: Aquaporin-like
Superfamily: Aquaporin-like
Family: Aquaporin-like

Phyre2

PDB 1l7v chain A

3D model

Region: 49 - 343
Aligned: 288
Modelled: 284
Confidence: 9.2%
Identity: 11%
Fold: ABC transporter involved in vitamin B12 uptake, BtuC
Superfamily: ABC transporter involved in vitamin B12 uptake, BtuC
Family: ABC transporter involved in vitamin B12 uptake, BtuC

Phyre2

PDB 3qnq chain D

3D model

Region: 222 - 258
Aligned: 37
Modelled: 37
Confidence: 8.7%
Identity: 5%
PDB header:membrane protein, transport protein
Chain: D: PDB Molecule:pts system, cellobiose-specific iic component;
PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system

Phyre2

PDB 1fft chain B domain 2

3D model

Region: 198 - 285
Aligned: 78
Modelled: 88
Confidence: 7.7%
Identity: 13%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 2oar chain A

3D model

Region: 175 - 260
Aligned: 86
Modelled: 86
Confidence: 7.5%
Identity: 13%
PDB header:membrane protein
Chain: A: PDB Molecule:large-conductance mechanosensitive channel;
PDBTitle: mechanosensitive channel of large conductance (mscl)

Phyre2
1

c3orgB_
2

d1y5ic1
3

c1w8xP_
4

c2w8aC_
5

c1ymgA_
6

d1ymga1
7

c3d9sB_
8

d1j4na_
9

d1l7va_
10

c3qnqD_
11

d1fftb2
12

c2oarA_



Detailed template information 

#
Template Alignment Coverage3D Model Confidence
% i.d. Template Information
1c3orgB_



52.3 11 PDB header:transport protein
Chain: B: PDB Molecule:cmclc;
PDBTitle: crystal structure of a eukaryotic clc transporter
2d1y5ic1



27.9 10 Fold:Heme-binding four-helical bundle
Superfamily:Respiratory nitrate reductase 1 gamma chain
Family:Respiratory nitrate reductase 1 gamma chain
3c1w8xP_



24.6 24 PDB header:virus
Chain: P: PDB Molecule:protein p16;
PDBTitle: structural analysis of prd1
4c2w8aC_



13.1 9 PDB header:membrane protein
Chain: C: PDB Molecule:glycine betaine transporter betp;
PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate
5c1ymgA_



11.9 18 PDB header:membrane protein
Chain: A: PDB Molecule:lens fiber major intrinsic protein;
PDBTitle: the channel architecture of aquaporin o at 2.2 angstrom resolution
6d1ymga1



11.9 18 Fold:Aquaporin-like
Superfamily:Aquaporin-like
Family:Aquaporin-like
7c3d9sB_



10.4 13 PDB header:membrane protein
Chain: B: PDB Molecule:aquaporin-5;
PDBTitle: human aquaporin 5 (aqp5) - high resolution x-ray structure
8d1j4na_



9.2 11 Fold:Aquaporin-like
Superfamily:Aquaporin-like
Family:Aquaporin-like
9d1l7va_



9.2 11 Fold:ABC transporter involved in vitamin B12 uptake, BtuC
Superfamily:ABC transporter involved in vitamin B12 uptake, BtuC
Family:ABC transporter involved in vitamin B12 uptake, BtuC
10c3qnqD_



8.7 5 PDB header:membrane protein, transport protein
Chain: D: PDB Molecule:pts system, cellobiose-specific iic component;
PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system
11d1fftb2



7.7 13 Fold:Transmembrane helix hairpin
Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region
Family:Cytochrome c oxidase subunit II-like, transmembrane region
12c2oarA_



7.5 13 PDB header:membrane protein
Chain: A: PDB Molecule:large-conductance mechanosensitive channel;
PDBTitle: mechanosensitive channel of large conductance (mscl)

Binding site prediction 

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite



Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
 
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
Disclaimer
Terms and Conditions
Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0