Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	R	Q	S	L	Q	A	V	L	P	E	I	S	G	N	K	T	S	S	L	R	K	S	V	C	S	D	L	L	T	L	F	N	S	P	H	S	A	L	P	S	L	L	V	S	G	M	P	E	W	Q	V	H	N	P	S	D	K	H
Secondary structure
SS confidence
Disorder		?	?	?												?																				?	?																			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	Q	S	W	Y	C	R	Q	L	R	S	A	L	L	F	H	E	P	R	I	A	A	L	Q	V	N	L	K	E	A	Y	C	H	T	L	A	I	S	L	E	I	M	L	Y	H	D	D	E	P	L	T	F	D	L	V	W	D	N	G	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130
Sequence		W	R	S	A	T	L	E	N	V	S
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2ia7 chain A domain 1 Region: 23 - 119 Aligned: 96 Modelled: 97 Confidence: 99.5% Identity: 15% Fold: gpW/gp25-like Superfamily: gpW/gp25-like Family: gpW/gp25-like Phyre2 PDB 1re5 chain A Region: 6 - 69 Aligned: 64 Modelled: 64 Confidence: 39.5% Identity: 14% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 2fen chain A Region: 3 - 69 Aligned: 67 Modelled: 67 Confidence: 33.8% Identity: 9% PDB header:isomerase Chain: A: PDB Molecule:3-carboxy-cis,cis-muconate lactonizing enzyme; PDBTitle: 3-carboxy-cis,cis-muconate lactonizing enzyme from agrobacterium2 radiobacter s2 Phyre2 PDB 1hy0 chain A Region: 6 - 69 Aligned: 60 Modelled: 64 Confidence: 24.2% Identity: 17% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 1tjv chain A Region: 6 - 47 Aligned: 42 Modelled: 42 Confidence: 22.5% Identity: 21% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 1fuo chain A Region: 3 - 42 Aligned: 40 Modelled: 40 Confidence: 22.3% Identity: 20% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 3c8t chain A Region: 6 - 69 Aligned: 64 Modelled: 64 Confidence: 22.1% Identity: 17% PDB header:lyase Chain: A: PDB Molecule:fumarate lyase; PDBTitle: crystal structure of fumarate lyase from mesorhizobium sp. bnc1 Phyre2 PDB 1q5n chain A Region: 6 - 69 Aligned: 64 Modelled: 64 Confidence: 21.9% Identity: 20% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 3ocf chain B Region: 3 - 42 Aligned: 40 Modelled: 40 Confidence: 21.3% Identity: 18% PDB header:lyase Chain: B: PDB Molecule:fumarate lyase:delta crystallin; PDBTitle: crystal structure of fumarate lyase:delta crystallin from brucella2 melitensis in native form Phyre2 PDB 3chg chain B Region: 43 - 78 Aligned: 32 Modelled: 36 Confidence: 19.9% Identity: 13% PDB header:ligand binding protein Chain: B: PDB Molecule:glycine betaine-binding protein; PDBTitle: the compatible solute-binding protein opuac from bacillus2 subtilis in complex with dmsa Phyre2 PDB 1jsw chain A Region: 3 - 42 Aligned: 40 Modelled: 40 Confidence: 19.1% Identity: 15% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 1k62 chain A Region: 6 - 57 Aligned: 52 Modelled: 52 Confidence: 18.2% Identity: 17% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 2lhu chain A Region: 29 - 51 Aligned: 23 Modelled: 23 Confidence: 17.1% Identity: 17% PDB header:structural protein Chain: A: PDB Molecule:mybpc3 protein; PDBTitle: structural insight into the unique cardiac myosin binding protein-c2 motif: a partially folded domain Phyre2 PDB 1tj7 chain A Region: 3 - 69 Aligned: 63 Modelled: 67 Confidence: 16.8% Identity: 14% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 1i0a chain A Region: 6 - 69 Aligned: 60 Modelled: 64 Confidence: 16.1% Identity: 18% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 PDB 2pfm chain A Region: 6 - 69 Aligned: 61 Modelled: 60 Confidence: 15.3% Identity: 16% PDB header:lyase Chain: A: PDB Molecule:adenylosuccinate lyase; PDBTitle: crystal structure of adenylosuccinate lyase (purb) from bacillus2 anthracis Phyre2 PDB 1yis chain A Region: 3 - 40 Aligned: 38 Modelled: 36 Confidence: 14.6% Identity: 11% PDB header:lyase Chain: A: PDB Molecule:adenylosuccinate lyase; PDBTitle: structural genomics of caenorhabditis elegans: adenylosuccinate lyase Phyre2 PDB 1h3g chain A domain 1 Region: 73 - 120 Aligned: 48 Modelled: 47 Confidence: 14.5% Identity: 13% Fold: Immunoglobulin-like beta-sandwich Superfamily: E set domains Family: E-set domains of sugar-utilizing enzymes Phyre2 PDB 2e9f chain C Region: 3 - 57 Aligned: 55 Modelled: 55 Confidence: 13.9% Identity: 13% PDB header:lyase Chain: C: PDB Molecule:argininosuccinate lyase; PDBTitle: crystal structure of t.th.hb8 argininosuccinate lyase complexed with2 l-arginine Phyre2 PDB 1dof chain A Region: 3 - 69 Aligned: 66 Modelled: 67 Confidence: 13.5% Identity: 11% Fold: L-aspartase-like Superfamily: L-aspartase-like Family: L-aspartase/fumarase Phyre2 1 d2ia7a1 2 d1re5a_ 3 c2fenA_ 4 d1hy0a_ 5 d1tjva_ 6 d1fuoa_ 7 c3c8tA_ 8 d1q5na_ 9 c3ocfB_ 10 c3chgB_ 11 d1jswa_ 12 d1k62a_ 13 c2lhuA_ 14 d1tj7a_ 15 d1i0aa_ 16 c2pfmA_ 17 c1yisA_ 18 d1h3ga1 19 c2e9fC_ 20 d1dofa_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d2ia7a1 99.5 15 Fold:gpW/gp25-like Superfamily:gpW/gp25-like Family:gpW/gp25-like 2 d1re5a_ 39.5 14 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 3 c2fenA_ 33.8 9 PDB header:isomerase Chain: A: PDB Molecule:3-carboxy-cis,cis-muconate lactonizing enzyme; PDBTitle: 3-carboxy-cis,cis-muconate lactonizing enzyme from agrobacterium2 radiobacter s2 4 d1hy0a_ 24.2 17 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 5 d1tjva_ 22.5 21 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 6 d1fuoa_ 22.3 20 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 7 c3c8tA_ 22.1 17 PDB header:lyase Chain: A: PDB Molecule:fumarate lyase; PDBTitle: crystal structure of fumarate lyase from mesorhizobium sp. bnc1 8 d1q5na_ 21.9 20 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 9 c3ocfB_ 21.3 18 PDB header:lyase Chain: B: PDB Molecule:fumarate lyase:delta crystallin; PDBTitle: crystal structure of fumarate lyase:delta crystallin from brucella2 melitensis in native form 10 c3chgB_ 19.9 13 PDB header:ligand binding protein Chain: B: PDB Molecule:glycine betaine-binding protein; PDBTitle: the compatible solute-binding protein opuac from bacillus2 subtilis in complex with dmsa 11 d1jswa_ 19.1 15 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 12 d1k62a_ 18.2 17 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 13 c2lhuA_ 17.1 17 PDB header:structural protein Chain: A: PDB Molecule:mybpc3 protein; PDBTitle: structural insight into the unique cardiac myosin binding protein-c2 motif: a partially folded domain 14 d1tj7a_ 16.8 14 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 15 d1i0aa_ 16.1 18 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 16 c2pfmA_ 15.3 16 PDB header:lyase Chain: A: PDB Molecule:adenylosuccinate lyase; PDBTitle: crystal structure of adenylosuccinate lyase (purb) from bacillus2 anthracis 17 c1yisA_ 14.6 11 PDB header:lyase Chain: A: PDB Molecule:adenylosuccinate lyase; PDBTitle: structural genomics of caenorhabditis elegans: adenylosuccinate lyase 18 d1h3ga1 14.5 13 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:E-set domains of sugar-utilizing enzymes 19 c2e9fC_ 13.9 13 PDB header:lyase Chain: C: PDB Molecule:argininosuccinate lyase; PDBTitle: crystal structure of t.th.hb8 argininosuccinate lyase complexed with2 l-arginine 20 d1dofa_ 13.5 11 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 21 d1f1oa_ not modelled 13.0 10 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 22 c3tl8K_ not modelled 11.6 16 PDB header:transferase/ligase Chain: K: PDB Molecule:effector protein hopab2; PDBTitle: the avrptob-bak1 complex reveals two structurally similar2 kinaseinteracting domains in a single type iii effector 23 c3tqmD_ not modelled 10.7 5 PDB header:protein binding Chain: D: PDB Molecule:ribosome-associated factor y; PDBTitle: structure of an ribosomal subunit interface protein from coxiella2 burnetii 24 c3e04C_ not modelled 10.6 16 PDB header:lyase Chain: C: PDB Molecule:fumarate hydratase; PDBTitle: crystal structure of human fumarate hydratase 25 c2vd6B_ not modelled 9.9 16 PDB header:lyase Chain: B: PDB Molecule:adenylosuccinate lyase; PDBTitle: human adenylosuccinate lyase in complex with its substrate2 n6-(1,2-dicarboxyethyl)-amp, and its products amp and3 fumarate. 26 d1c3ca_ not modelled 9.6 13 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 27 c2rqlA_ not modelled 9.2 15 PDB header:translation Chain: A: PDB Molecule:probable sigma-54 modulation protein; PDBTitle: solution structure of the e. coli ribosome hibernation2 promoting factor hpf 28 c3bhgA_ not modelled 8.9 17 PDB header:lyase Chain: A: PDB Molecule:adenylosuccinate lyase; PDBTitle: crystal structure of adenylosuccinate lyase from legionella2 pneumophila 29 d1bg4a_ not modelled 8.7 19 Fold:TIM beta/alpha-barrel Superfamily:(Trans)glycosidases Family:beta-glycanases 30 c1h6wA_ not modelled 8.2 14 PDB header:structural protein Chain: A: PDB Molecule:bacteriophage t4 short tail fibre; PDBTitle: crystal structure of a heat- and protease-stable fragment2 of the bacteriophage t4 short fibre 31 d1ddwa_ not modelled 7.5 14 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Enabled/VASP homology 1 domain (EVH1 domain) 32 c2fyzC_ not modelled 6.9 18 PDB header:protein binding Chain: C: PDB Molecule:fusion glycoprotein f0; PDBTitle: structural of mumps virus fusion protein core 33 d1ft8e_ not modelled 6.9 21 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Non-canonical RBD domain 34 d2arha1 not modelled 6.9 10 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:Aq 1966-like 35 c2ptsA_ not modelled 6.7 17 PDB header:lyase Chain: A: PDB Molecule:adenylosuccinate lyase; PDBTitle: crystal structure of wild type escherichia coli adenylosuccinate lyase 36 d1tm0a_ not modelled 6.0 9 Fold:Diaminopimelate epimerase-like Superfamily:Diaminopimelate epimerase-like Family:Proline racemase 37 c3juaB_ not modelled 5.9 63 PDB header:transcription Chain: B: PDB Molecule:65 kda yes-associated protein; PDBTitle: structural basis of yap recognition by tead4 in the hippo pathway 38 d2i8da1 not modelled 5.8 10 Fold:Secretion chaperone-like Superfamily:YdhG-like Family:YdhG-like 39 c3pt1A_ not modelled 5.7 38 PDB header:hydrolase Chain: A: PDB Molecule:upf0364 protein ymr027w; PDBTitle: structure of duf89 from saccharomyces cerevisiae co-crystallized with2 f6p. 40 d2oc6a1 not modelled 5.7 13 Fold:Secretion chaperone-like Superfamily:YdhG-like Family:YdhG-like 41 c3hfdA_ not modelled 5.5 9 PDB header:chaperone, protein transport Chain: A: PDB Molecule:nucleosome assembly protein 1; PDBTitle: nucleosome assembly protein 1 from plasmodium knowlesi 42 d2ywqa1 not modelled 5.4 16 Fold:Ribosome binding protein Y (YfiA homologue) Superfamily:Ribosome binding protein Y (YfiA homologue) Family:Ribosome binding protein Y (YfiA homologue) 43 d1j3ua_ not modelled 5.4 14 Fold:L-aspartase-like Superfamily:L-aspartase-like Family:L-aspartase/fumarase 44 c3gtdB_ not modelled 5.2 10 PDB header:lyase Chain: B: PDB Molecule:fumarate hydratase class ii; PDBTitle: 2.4 angstrom crystal structure of fumarate hydratase from rickettsia2 prowazekii 45 d1rhoa_ not modelled 5.2 19 Fold:Immunoglobulin-like beta-sandwich Superfamily:E set domains Family:RhoGDI-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0