Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	S	I	F	K	P	A	P	H	K	A	R	L	P	A	A	E	I	D	P	T	Y	R	R	L	R	W	Q	I	F	L	G	I	F	F	G	Y	A	A	Y	Y	L	V	R	K	N	F	A	L	A	M	P	Y	L	V	E	Q	G	F
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?	?	?		?																																			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		S	R	G	D	L	G	F	A	L	S	G	I	S	I	A	Y	G	F	S	K	F	I	M	G	S	V	S	D	R	S	N	P	R	V	F	L	P	A	G	L	I	L	A	A	A	V	M	L	F	M	G	F	V	P	W	A	T	S	S	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	V	M	F	V	L	L	F	L	C	G	W	F	Q	G	M	G	W	P	P	C	G	R	T	M	V	H	W	W	S	Q	K	E	R	G	G	I	V	S	V	W	N	C	A	H	N	V	G	G	G	I	P	P	L	L	F	L	L	G	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	W	F	N	D	W	H	A	A	L	Y	M	P	A	F	C	A	I	L	V	A	L	F	A	F	A	M	M	R	D	T	P	Q	S	C	G	L	P	P	I	E	E	Y	K	N	D	Y	P	D	D	Y	N	E	K	A	E	Q	E	L	T
Secondary structure
SS confidence
Disorder																																					?	?		?					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		A	K	Q	I	F	M	Q	Y	V	L	P	N	K	L	L	W	Y	I	A	I	A	N	V	F	V	Y	L	L	R	Y	G	I	L	D	W	S	P	T	Y	L	K	E	V	K	H	F	A	L	D	K	S	S	W	A	Y	F	L	Y	E	Y
Secondary structure
SS confidence
Disorder		?	?	?																																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	G	I	P	G	T	L	L	C	G	W	M	S	D	K	V	F	R	G	N	R	G	A	T	G	V	F	F	M	T	L	V	T	I	A	T	I	V	Y	W	M	N	P	A	G	N	P	T	V	D	M	I	C	M	I	V	I	G	F	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		I	Y	G	P	V	M	L	I	G	L	H	A	L	E	L	A	P	K	K	A	A	G	T	A	A	G	F	T	G	L	F	G	Y	L	G	G	S	V	A	A	S	A	I	V	G	Y	T	V	D	F	F	G	W	D	G	G	F	M	V	M
Secondary structure
SS confidence
Disorder																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.
Sequence		I	G	G	S	I	L	A	V	I	L	L	I	V	V	M	I	G	E	K	R	R	H	E	Q	L	L	Q	E	R	N	G	G
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1pw4 chain A Region: 5 - 448 Aligned: 431 Modelled: 431 Confidence: 100.0% Identity: 97% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 1pv7 chain A Region: 19 - 450 Aligned: 414 Modelled: 432 Confidence: 100.0% Identity: 12% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 3o7p chain A Region: 25 - 438 Aligned: 401 Modelled: 414 Confidence: 100.0% Identity: 8% PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) Phyre2 PDB 2gfp chain A Region: 30 - 428 Aligned: 369 Modelled: 377 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 2xut chain C Region: 28 - 434 Aligned: 402 Modelled: 407 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter. Phyre2 PDB 3b9y chain A Region: 16 - 253 Aligned: 228 Modelled: 238 Confidence: 92.5% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:ammonium transporter family rh-like protein; PDBTitle: crystal structure of the nitrosomonas europaea rh protein Phyre2 PDB 3mku chain A Region: 15 - 449 Aligned: 433 Modelled: 433 Confidence: 44.4% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:multi antimicrobial extrusion protein (na(+)/drug PDBTitle: structure of a cation-bound multidrug and toxin compound extrusion2 (mate) transporter Phyre2 PDB 3qnq chain D Region: 401 - 451 Aligned: 51 Modelled: 51 Confidence: 40.8% Identity: 18% PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system Phyre2 PDB 3hd6 chain A Region: 14 - 238 Aligned: 219 Modelled: 225 Confidence: 39.7% Identity: 10% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg Phyre2 PDB 2rdd chain B Region: 420 - 448 Aligned: 29 Modelled: 29 Confidence: 26.1% Identity: 3% PDB header:membrane protein/transport protein Chain: B: PDB Molecule:upf0092 membrane protein yajc; PDBTitle: x-ray crystal structure of acrb in complex with a novel2 transmembrane helix. Phyre2 PDB 2g9p chain A Region: 82 - 95 Aligned: 14 Modelled: 14 Confidence: 9.1% Identity: 7% PDB header:antimicrobial protein Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a; PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom Phyre2 PDB 3prr chain T Region: 414 - 444 Aligned: 31 Modelled: 31 Confidence: 5.8% Identity: 16% PDB header:photosynthesis Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii in complex with2 terbutryn (part 2 of 2). this file contains second monomer of psii3 dimer Phyre2 PDB 3prq chain T Region: 414 - 444 Aligned: 31 Modelled: 31 Confidence: 5.8% Identity: 16% PDB header:photosynthesis Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii in complex with2 terbutryn (part 1 of 2). this file contains first monomer of psii3 dimer Phyre2 PDB 3bz1 chain T Region: 414 - 444 Aligned: 31 Modelled: 31 Confidence: 5.8% Identity: 16% PDB header:electron transport Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii (part 12 of 2). this file contains first monomer of psii dimer Phyre2 PDB 3bz2 chain T Region: 414 - 444 Aligned: 31 Modelled: 31 Confidence: 5.8% Identity: 16% PDB header:electron transport Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii (part 22 of 2). this file contains second monomer of psii dimer Phyre2 PDB 3dtu chain B domain 2 Region: 408 - 451 Aligned: 44 Modelled: 44 Confidence: 5.7% Identity: 7% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 2knc chain A Region: 413 - 452 Aligned: 40 Modelled: 40 Confidence: 5.4% Identity: 23% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 1k4u chain P Region: 6 - 19 Aligned: 14 Modelled: 14 Confidence: 5.2% Identity: 36% PDB header:hormone/growth factor Chain: P: PDB Molecule:phagocyte nadph oxidase subunit p47phox; PDBTitle: solution structure of the c-terminal sh3 domain of p67phox2 complexed with the c-terminal tail region of p47phox Phyre2 PDB 2jyn chain A Region: 5 - 32 Aligned: 28 Modelled: 28 Confidence: 5.2% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0368 protein ypl225w; PDBTitle: a novel solution nmr structure of protein yst0336 from2 saccharomyces cerevisiae. northeast structural genomics3 consortium target yt51/ontario centre for structural4 proteomics target yst0336 Phyre2 1 d1pw4a_ 2 d1pv7a_ 3 c3o7pA_ 4 c2gfpA_ 5 c2xutC_ 6 c3b9yA_ 7 c3mkuA_ 8 c3qnqD_ 9 c3hd6A_ 10 c2rddB_ 11 c2g9pA_ 12 c3prrT_ 13 c3prqT_ 14 c3bz1T_ 15 c3bz2T_ 16 d3dtub2 17 c2kncA_ 18 c1k4uP_ 19 c2jynA_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1pw4a_ 100.0 97 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:Glycerol-3-phosphate transporter 2 d1pv7a_ 100.0 12 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:LacY-like proton/sugar symporter 3 c3o7pA_ 100.0 8 PDB header:transport protein Chain: A: PDB Molecule:l-fucose-proton symporter; PDBTitle: crystal structure of the e.coli fucose:proton symporter, fucp (n162a) 4 c2gfpA_ 100.0 15 PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli 5 c2xutC_ 100.0 12 PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter. 6 c3b9yA_ 92.5 12 PDB header:transport protein Chain: A: PDB Molecule:ammonium transporter family rh-like protein; PDBTitle: crystal structure of the nitrosomonas europaea rh protein 7 c3mkuA_ 44.4 9 PDB header:transport protein Chain: A: PDB Molecule:multi antimicrobial extrusion protein (na(+)/drug PDBTitle: structure of a cation-bound multidrug and toxin compound extrusion2 (mate) transporter 8 c3qnqD_ 40.8 18 PDB header:membrane protein, transport protein Chain: D: PDB Molecule:pts system, cellobiose-specific iic component; PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system 9 c3hd6A_ 39.7 10 PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg 10 c2rddB_ 26.1 3 PDB header:membrane protein/transport protein Chain: B: PDB Molecule:upf0092 membrane protein yajc; PDBTitle: x-ray crystal structure of acrb in complex with a novel2 transmembrane helix. 11 c2g9pA_ 9.1 7 PDB header:antimicrobial protein Chain: A: PDB Molecule:antimicrobial peptide latarcin 2a; PDBTitle: nmr structure of a novel antimicrobial peptide, latarcin 2a,2 from spider (lachesana tarabaevi) venom 12 c3prrT_ 5.8 16 PDB header:photosynthesis Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii in complex with2 terbutryn (part 2 of 2). this file contains second monomer of psii3 dimer 13 c3prqT_ 5.8 16 PDB header:photosynthesis Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii in complex with2 terbutryn (part 1 of 2). this file contains first monomer of psii3 dimer 14 c3bz1T_ 5.8 16 PDB header:electron transport Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii (part 12 of 2). this file contains first monomer of psii dimer 15 c3bz2T_ 5.8 16 PDB header:electron transport Chain: T: PDB Molecule:photosystem ii reaction center protein t; PDBTitle: crystal structure of cyanobacterial photosystem ii (part 22 of 2). this file contains second monomer of psii dimer 16 d3dtub2 5.7 7 Fold:Transmembrane helix hairpin Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region Family:Cytochrome c oxidase subunit II-like, transmembrane region 17 c2kncA_ 5.4 23 PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 18 c1k4uP_ 5.2 36 PDB header:hormone/growth factor Chain: P: PDB Molecule:phagocyte nadph oxidase subunit p47phox; PDBTitle: solution structure of the c-terminal sh3 domain of p67phox2 complexed with the c-terminal tail region of p47phox 19 c2jynA_ 5.2 18 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:upf0368 protein ypl225w; PDBTitle: a novel solution nmr structure of protein yst0336 from2 saccharomyces cerevisiae. northeast structural genomics3 consortium target yt51/ontario centre for structural4 proteomics target yst0336

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0