Secondary structure and disorder prediction

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Sequence		M	T	K	K	I	K	C	A	Y	H	L	C	K	K	D	V	E	E	S	K	A	I	E	R	M	L	H	F	M	H	G	I	L	S	K	D	E	P	R	K	Y	C	S	E	A	C	A	E	K	D	Q	M	A	H	E	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?									?	?																	?	?	?	?																	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1jjd chain A Region: 34 - 48 Aligned: 15 Modelled: 15 Confidence: 33.3% Identity: 47% Fold: Metallothionein Superfamily: Metallothionein Family: Metallothionein Phyre2 PDB 2jz3 chain A Region: 10 - 16 Aligned: 7 Modelled: 7 Confidence: 29.1% Identity: 71% PDB header:transcription inhibitor/transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: socs box elonginbc ternary complex Phyre2 PDB 1lv3 chain A Region: 41 - 50 Aligned: 10 Modelled: 10 Confidence: 27.5% Identity: 40% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: Hypothetical zinc finger protein YacG Phyre2 PDB 1u5s chain B domain 1 Region: 7 - 17 Aligned: 9 Modelled: 11 Confidence: 19.9% Identity: 33% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 1c94 chain B Region: 20 - 28 Aligned: 9 Modelled: 9 Confidence: 11.4% Identity: 44% PDB header:gene regulation Chain: B: PDB Molecule:retro-gcn4 leucine zipper; PDBTitle: reversing the sequence of the gcn4 leucine zipper does not2 affect its fold. Phyre2 PDB 2w0t chain A Region: 36 - 47 Aligned: 12 Modelled: 12 Confidence: 9.6% Identity: 25% PDB header:transcription Chain: A: PDB Molecule:lethal(3)malignant brain tumor-like 2 protein; PDBTitle: solution structure of the fcs zinc finger domain of human2 lmbl2 Phyre2 PDB 2odd chain A Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 8.5% Identity: 43% PDB header:metal binding protein Chain: A: PDB Molecule:protein cbfa2t1; PDBTitle: solution structure of the mynd domain from aml1-eto2 complexed with smrt, a corepressor Phyre2 PDB 1qcr chain D Region: 47 - 56 Aligned: 10 Modelled: 10 Confidence: 8.3% Identity: 30% PDB header: PDB COMPND: Phyre2 PDB 2dj8 chain A domain 1 Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 8.2% Identity: 43% Fold: HIT/MYND zinc finger-like Superfamily: HIT/MYND zinc finger-like Family: MYND zinc finger Phyre2 PDB 1pg5 chain B domain 2 Region: 4 - 26 Aligned: 21 Modelled: 23 Confidence: 7.8% Identity: 29% Fold: Rubredoxin-like Superfamily: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain Family: Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain Phyre2 PDB 2dj8 chain A Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 7.5% Identity: 43% PDB header:metal binding protein Chain: A: PDB Molecule:protein cbfa2t1; PDBTitle: solution structure of zf-mynd domain of protein cbfa2ti2 (protein mtg8) Phyre2 PDB 3qwv chain A Region: 41 - 56 Aligned: 16 Modelled: 16 Confidence: 6.7% Identity: 38% PDB header:transferase Chain: A: PDB Molecule:set and mynd domain-containing protein 2; PDBTitle: crystal structure of histone lysine methyltransferase smyd2 in complex2 with the cofactor product adohcy Phyre2 PDB 2jw6 chain A Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 6.7% Identity: 50% PDB header:transcription Chain: A: PDB Molecule:deformed epidermal autoregulatory factor 1 homolog; PDBTitle: solution structure of the deaf1 mynd domain Phyre2 PDB 2d8q chain A domain 1 Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 6.6% Identity: 36% Fold: HIT/MYND zinc finger-like Superfamily: HIT/MYND zinc finger-like Family: MYND zinc finger Phyre2 PDB 1u6p chain A Region: 6 - 14 Aligned: 7 Modelled: 9 Confidence: 6.4% Identity: 71% Fold: Retrovirus zinc finger-like domains Superfamily: Retrovirus zinc finger-like domains Family: Retrovirus zinc finger-like domains Phyre2 PDB 1mv4 chain B Region: 12 - 18 Aligned: 7 Modelled: 7 Confidence: 6.4% Identity: 29% PDB header:de novo protein Chain: B: PDB Molecule:tropomyosin 1 alpha chain; PDBTitle: tm9a251-284: a peptide model of the c-terminus of a rat2 striated alpha tropomyosin Phyre2 PDB 1ppj chain D domain 1 Region: 47 - 56 Aligned: 10 Modelled: 10 Confidence: 6.2% Identity: 30% Fold: Cytochrome c Superfamily: Cytochrome c Family: Cytochrome bc1 domain Phyre2 PDB 2jw6 chain A domain 1 Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 6.1% Identity: 50% Fold: HIT/MYND zinc finger-like Superfamily: HIT/MYND zinc finger-like Family: MYND zinc finger Phyre2 PDB 1a6s chain A Region: 9 - 29 Aligned: 19 Modelled: 21 Confidence: 5.9% Identity: 37% Fold: Retroviral matrix proteins Superfamily: Retroviral matrix proteins Family: GAG polyprotein M-domain Phyre2 PDB 2dan chain A Region: 41 - 54 Aligned: 14 Modelled: 14 Confidence: 5.6% Identity: 36% PDB header:metal binding protein Chain: A: PDB Molecule:zinc finger mynd domain containing protein 10; PDBTitle: the solution structure of the mynd domain (leu384-cys430)2 of human zinc finger mynd domain containing protein 10 Phyre2 1 d1jjda_ 2 c2jz3A_ 3 d1lv3a_ 4 d1u5sb1 5 c1c94B_ 6 c2w0tA_ 7 c2oddA_ 8 c1qcrD_ 9 d2dj8a1 10 d1pg5b2 11 c2dj8A_ 12 c3qwvA_ 13 c2jw6A_ 14 d2d8qa1 15 d1u6pa_ 16 c1mv4B_ 17 d1ppjd1 18 d2jw6a1 19 d1a6sa_ 20 c2danA_ 21 22 23 24 25

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1jjda_ 33.3 47 Fold:Metallothionein Superfamily:Metallothionein Family:Metallothionein 2 c2jz3A_ 29.1 71 PDB header:transcription inhibitor/transcription Chain: A: PDB Molecule:suppressor of cytokine signaling 3; PDBTitle: socs box elonginbc ternary complex 3 d1lv3a_ 27.5 40 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:Hypothetical zinc finger protein YacG 4 d1u5sb1 19.9 33 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 5 c1c94B_ 11.4 44 PDB header:gene regulation Chain: B: PDB Molecule:retro-gcn4 leucine zipper; PDBTitle: reversing the sequence of the gcn4 leucine zipper does not2 affect its fold. 6 c2w0tA_ 9.6 25 PDB header:transcription Chain: A: PDB Molecule:lethal(3)malignant brain tumor-like 2 protein; PDBTitle: solution structure of the fcs zinc finger domain of human2 lmbl2 7 c2oddA_ 8.5 43 PDB header:metal binding protein Chain: A: PDB Molecule:protein cbfa2t1; PDBTitle: solution structure of the mynd domain from aml1-eto2 complexed with smrt, a corepressor 8 c1qcrD_ 8.3 30 PDB header: PDB COMPND: 9 d2dj8a1 8.2 43 Fold:HIT/MYND zinc finger-like Superfamily:HIT/MYND zinc finger-like Family:MYND zinc finger 10 d1pg5b2 7.8 29 Fold:Rubredoxin-like Superfamily:Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain Family:Aspartate carbamoyltransferase, Regulatory-chain, C-terminal domain 11 c2dj8A_ 7.5 43 PDB header:metal binding protein Chain: A: PDB Molecule:protein cbfa2t1; PDBTitle: solution structure of zf-mynd domain of protein cbfa2ti2 (protein mtg8) 12 c3qwvA_ 6.7 38 PDB header:transferase Chain: A: PDB Molecule:set and mynd domain-containing protein 2; PDBTitle: crystal structure of histone lysine methyltransferase smyd2 in complex2 with the cofactor product adohcy 13 c2jw6A_ 6.7 50 PDB header:transcription Chain: A: PDB Molecule:deformed epidermal autoregulatory factor 1 homolog; PDBTitle: solution structure of the deaf1 mynd domain 14 d2d8qa1 6.6 36 Fold:HIT/MYND zinc finger-like Superfamily:HIT/MYND zinc finger-like Family:MYND zinc finger 15 d1u6pa_ 6.4 71 Fold:Retrovirus zinc finger-like domains Superfamily:Retrovirus zinc finger-like domains Family:Retrovirus zinc finger-like domains 16 c1mv4B_ 6.4 29 PDB header:de novo protein Chain: B: PDB Molecule:tropomyosin 1 alpha chain; PDBTitle: tm9a251-284: a peptide model of the c-terminus of a rat2 striated alpha tropomyosin 17 d1ppjd1 6.2 30 Fold:Cytochrome c Superfamily:Cytochrome c Family:Cytochrome bc1 domain 18 d2jw6a1 6.1 50 Fold:HIT/MYND zinc finger-like Superfamily:HIT/MYND zinc finger-like Family:MYND zinc finger 19 d1a6sa_ 5.9 37 Fold:Retroviral matrix proteins Superfamily:Retroviral matrix proteins Family:GAG polyprotein M-domain 20 c2danA_ 5.6 36 PDB header:metal binding protein Chain: A: PDB Molecule:zinc finger mynd domain containing protein 10; PDBTitle: the solution structure of the mynd domain (leu384-cys430)2 of human zinc finger mynd domain containing protein 10 21 c3iz5w_ not modelled 5.6 21 PDB header:ribosome Chain: W: PDB Molecule:60s ribosomal protein l22 (l22e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome 22 c2yiuE_ not modelled 5.6 50 PDB header:oxidoreductase Chain: E: PDB Molecule:cytochrome c1, heme protein; PDBTitle: x-ray structure of the dimeric cytochrome bc1 complex from2 the soil bacterium paracoccus denitrificans at 2.73 angstrom resolution 23 d1ubdc2 not modelled 5.5 44 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 24 d2dana1 not modelled 5.5 36 Fold:HIT/MYND zinc finger-like Superfamily:HIT/MYND zinc finger-like Family:MYND zinc finger 25 d3cx5d1 not modelled 5.4 40 Fold:Cytochrome c Superfamily:Cytochrome c Family:Cytochrome bc1 domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0