Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	N	S	L	Q	I	L	S	F	V	G	F	T	L	L	V	A	V	I	T	W	W	K	V	R	K	T	D	T	G	S	Q	Q	G	Y	F	L	A	G	R	S	L	K	A	P	V	I	A	A	S	L	M	L	T	N	L	S	T	E	Q
Secondary structure
SS confidence
Disorder		?	?																								?	?	?	?	?	?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	V	G	L	S	G	Q	A	Y	K	S	G	M	S	V	M	G	W	E	V	T	S	A	V	T	L	I	F	L	A	L	I	F	L	P	R	Y	L	K	R	G	I	A	T	I	P	D	F	L	E	E	R	Y	D	K	T	T	R	I	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	D	F	C	F	L	I	A	T	G	V	C	F	L	P	I	V	L	Y	S	G	A	L	A	L	N	S	L	F	H	V	G	E	S	L	Q	I	S	H	G	A	A	I	W	L	L	V	I	L	L	G	L	A	G	I	L	Y	A	V	I
Secondary structure
SS confidence
Disorder																														?	?	?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	G	L	R	A	M	A	V	A	D	S	I	N	G	I	G	L	V	I	G	G	L	M	V	P	V	F	G	L	I	A	M	G	K	G	S	F	M	Q	G	I	E	Q	L	T	T	V	H	A	E	K	L	N	S	I	G	G	P	T	D
Secondary structure
SS confidence
Disorder																																																?		?								?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	L	P	I	G	A	A	F	T	G	L	I	L	V	N	T	F	Y	W	C	T	N	Q	G	I	V	Q	R	T	L	A	S	K	S	L	A	E	G	Q	K	G	A	L	L	T	A	V	L	K	M	L	D	P	L	V	L	V	L	P	G
Secondary structure
SS confidence
Disorder		?																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		L	I	A	F	H	L	Y	Q	D	L	P	K	A	D	M	A	Y	P	T	L	V	N	N	V	L	P	V	P	M	V	G	F	F	G	A	V	L	F	G	A	V	I	S	T	F	N	G	F	L	N	S	A	S	T	L	F	S	M	G	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		Y	R	R	I	I	N	Q	N	A	E	P	Q	Q	L	V	T	V	G	R	K	F	G	F	F	I	A	I	V	S	V	L	V	A	P	W	I	A	N	A	P	Q	G	L	Y	S	W	M	K	Q	L	N	G	I	Y	N	V	P	L	V	T
Secondary structure
SS confidence
Disorder										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		I	I	I	M	G	F	F	F	P	R	I	P	A	L	A	A	K	V	A	M	G	I	G	I	I	S	Y	I	T	I	N	Y	L	V	K	F	D	F	H	F	L	Y	V	L	A	C	T	F	C	I	N	V	V	V	M	L	V	I	G	F
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540
Sequence		I	K	P	R	A	T	P	F	T	F	K	D	A	F	A	V	D	M	K	P	W	K	N	V	K	I	A	S	I	G	I	L	F	A	M	I	G	V	Y	A	G	L	A	E	F	G	G	Y	G	T	R	W	L	A	M	I	S	Y	F	I
Secondary structure
SS confidence
Disorder																																																?			?
Disorder confidence
		.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.
Sequence		A	A	V	V	I	V	Y	L	I	F	D	S	W	R	H	R	H	D	P	A	V	T	F	T	P	D	G	K	D	S	L
Secondary structure
SS confidence
Disorder																							?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2xq2 chain A Region: 2 - 556 Aligned: 521 Modelled: 521 Confidence: 100.0% Identity: 25% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt Phyre2 PDB 3dh4 chain A Region: 23 - 523 Aligned: 489 Modelled: 474 Confidence: 100.0% Identity: 26% PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus Phyre2 PDB 2jln chain A Region: 25 - 497 Aligned: 440 Modelled: 440 Confidence: 99.4% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter Phyre2 PDB 3gia chain A Region: 39 - 494 Aligned: 429 Modelled: 429 Confidence: 99.1% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter Phyre2 PDB 3lrc chain C Region: 40 - 487 Aligned: 402 Modelled: 402 Confidence: 98.2% Identity: 8% PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) Phyre2 PDB 3hfx chain A Region: 2 - 427 Aligned: 405 Modelled: 424 Confidence: 97.8% Identity: 15% PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter Phyre2 PDB 2w8a chain C Region: 6 - 427 Aligned: 403 Modelled: 419 Confidence: 97.7% Identity: 14% PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate Phyre2 PDB 2a65 chain A domain 1 Region: 49 - 524 Aligned: 437 Modelled: 437 Confidence: 85.7% Identity: 12% Fold: SNF-like Superfamily: SNF-like Family: SNF-like Phyre2 PDB 3rlb chain A Region: 375 - 481 Aligned: 98 Modelled: 107 Confidence: 17.0% Identity: 17% PDB header:thiamine-binding protein Chain: A: PDB Molecule:thit; PDBTitle: crystal structure at 2.0 a of the s-component for thiamin from an ecf-2 type abc transporter Phyre2 PDB 2ky5 chain A Region: 105 - 115 Aligned: 11 Modelled: 11 Confidence: 11.5% Identity: 45% PDB header:cell adhesion Chain: A: PDB Molecule:platelet endothelial cell adhesion molecule; PDBTitle: solution structure of the pecam-1 cytoplasmic tail with dpc Phyre2 PDB 3mk7 chain F Region: 3 - 66 Aligned: 64 Modelled: 64 Confidence: 8.1% Identity: 16% PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase Phyre2 PDB 3fxd chain D Region: 560 - 569 Aligned: 10 Modelled: 10 Confidence: 7.5% Identity: 70% PDB header:unknown function Chain: D: PDB Molecule:protein icmr; PDBTitle: crystal structure of interacting domains of icmr and icmq Phyre2 PDB 1fft chain B domain 2 Region: 532 - 571 Aligned: 40 Modelled: 40 Confidence: 7.4% Identity: 13% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 3m7b chain A Region: 429 - 565 Aligned: 135 Modelled: 137 Confidence: 7.1% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha Phyre2 PDB 1w8x chain P Region: 538 - 567 Aligned: 30 Modelled: 30 Confidence: 6.9% Identity: 23% PDB header:virus Chain: P: PDB Molecule:protein p16; PDBTitle: structural analysis of prd1 Phyre2 PDB 2fhz chain B domain 1 Region: 556 - 568 Aligned: 13 Modelled: 13 Confidence: 6.8% Identity: 46% Fold: Colicin D/E5 nuclease domain Superfamily: Colicin D/E5 nuclease domain Family: Colicin E5 nuclease domain Phyre2 PDB 2axt chain I domain 1 Region: 538 - 562 Aligned: 24 Modelled: 25 Confidence: 6.5% Identity: 29% Fold: Single transmembrane helix Superfamily: Photosystem II reaction center protein I, PsbI Family: PsbI-like Phyre2 PDB 1si2 chain A Region: 103 - 114 Aligned: 12 Modelled: 12 Confidence: 6.2% Identity: 17% Fold: SH3-like barrel Superfamily: PAZ domain Family: PAZ domain Phyre2 PDB 3o7x chain C Region: 103 - 114 Aligned: 12 Modelled: 12 Confidence: 5.2% Identity: 17% PDB header:rna binding protein Chain: C: PDB Molecule:piwi-like protein 2; PDBTitle: crystal structure of human hili paz domain Phyre2 1 c2xq2A_ 2 c3dh4A_ 3 c2jlnA_ 4 c3giaA_ 5 c3lrcC_ 6 c3hfxA_ 7 c2w8aC_ 8 d2a65a1 9 c3rlbA_ 10 c2ky5A_ 11 c3mk7F_ 12 c3fxdD_ 13 d1fftb2 14 c3m7bA_ 15 c1w8xP_ 16 d2fhzb1 17 d2axti1 18 d1si2a_ 19 c3o7xC_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2xq2A_ 100.0 25 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: structure of the k294a mutant of vsglt 2 c3dh4A_ 100.0 26 PDB header:transport protein Chain: A: PDB Molecule:sodium/glucose cotransporter; PDBTitle: crystal structure of sodium/sugar symporter with bound galactose from2 vibrio parahaemolyticus 3 c2jlnA_ 99.4 10 PDB header:membrane protein Chain: A: PDB Molecule:mhp1; PDBTitle: structure of mhp1, a nucleobase-cation-symport-1 family2 transporter 4 c3giaA_ 99.1 9 PDB header:transport protein Chain: A: PDB Molecule:uncharacterized protein mj0609; PDBTitle: crystal structure of apct transporter 5 c3lrcC_ 98.2 8 PDB header:transport protein Chain: C: PDB Molecule:arginine/agmatine antiporter; PDBTitle: structure of e. coli adic (p1) 6 c3hfxA_ 97.8 15 PDB header:transport protein Chain: A: PDB Molecule:l-carnitine/gamma-butyrobetaine antiporter; PDBTitle: crystal structure of carnitine transporter 7 c2w8aC_ 97.7 14 PDB header:membrane protein Chain: C: PDB Molecule:glycine betaine transporter betp; PDBTitle: crystal structure of the sodium-coupled glycine betaine2 symporter betp from corynebacterium glutamicum with bound3 substrate 8 d2a65a1 85.7 12 Fold:SNF-like Superfamily:SNF-like Family:SNF-like 9 c3rlbA_ 17.0 17 PDB header:thiamine-binding protein Chain: A: PDB Molecule:thit; PDBTitle: crystal structure at 2.0 a of the s-component for thiamin from an ecf-2 type abc transporter 10 c2ky5A_ 11.5 45 PDB header:cell adhesion Chain: A: PDB Molecule:platelet endothelial cell adhesion molecule; PDBTitle: solution structure of the pecam-1 cytoplasmic tail with dpc 11 c3mk7F_ 8.1 16 PDB header:oxidoreductase Chain: F: PDB Molecule:cytochrome c oxidase, cbb3-type, subunit p; PDBTitle: the structure of cbb3 cytochrome oxidase 12 c3fxdD_ 7.5 70 PDB header:unknown function Chain: D: PDB Molecule:protein icmr; PDBTitle: crystal structure of interacting domains of icmr and icmq 13 d1fftb2 7.4 13 Fold:Transmembrane helix hairpin Superfamily:Cytochrome c oxidase subunit II-like, transmembrane region Family:Cytochrome c oxidase subunit II-like, transmembrane region 14 c3m7bA_ 7.1 13 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:tellurite resistance protein teha homolog; PDBTitle: crystal structure of plant slac1 homolog teha 15 c1w8xP_ 6.9 23 PDB header:virus Chain: P: PDB Molecule:protein p16; PDBTitle: structural analysis of prd1 16 d2fhzb1 6.8 46 Fold:Colicin D/E5 nuclease domain Superfamily:Colicin D/E5 nuclease domain Family:Colicin E5 nuclease domain 17 d2axti1 6.5 29 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein I, PsbI Family:PsbI-like 18 d1si2a_ 6.2 17 Fold:SH3-like barrel Superfamily:PAZ domain Family:PAZ domain 19 c3o7xC_ 5.2 17 PDB header:rna binding protein Chain: C: PDB Molecule:piwi-like protein 2; PDBTitle: crystal structure of human hili paz domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0