Secondary structure and disorder prediction

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Sequence		M	V	S	A	L	I	T	V	A	V	I	A	W	C	A	Q	L	A	L	G	G	W	Q	I	S	R	F	N	R	A	F	D	T	L	C	Q	Q	G	R	V	G	V	G	R	S	S	G	R	F	K	P	R	V	V	V	A	I	A	L	D
Secondary structure
SS confidence
Disorder		?																																							?	?			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.
Sequence		D	Q	Q	R	I	V	D	T	L	F	M	K	G	L	T	V	F	A	R	P	Q	K	I	P	A	I	T	G	M	H	A	G	D	L	Q	P	D	V	I	F	P	H	D	P	L	S	Q	N	A	L	S	L	A	L	K	L	K	R	G
Secondary structure
SS confidence
Disorder																																					?				?	?	?															?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3fc7 chain B Region: 55 - 118 Aligned: 58 Modelled: 64 Confidence: 48.8% Identity: 9% PDB header:transferase Chain: B: PDB Molecule:htr-like protein; PDBTitle: the crystal structure of a domain of htr-like protein from haloarcula2 marismortui atcc 43049 Phyre2 PDB 3fg8 chain B Region: 49 - 118 Aligned: 60 Modelled: 70 Confidence: 37.6% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein rha05790; PDBTitle: crystal structure of pas domain of rha05790 Phyre2 PDB 1cq3 chain A Region: 68 - 90 Aligned: 23 Modelled: 23 Confidence: 32.0% Identity: 26% Fold: Soluble secreted chemokine inhibitor, VCCI Superfamily: Soluble secreted chemokine inhibitor, VCCI Family: Soluble secreted chemokine inhibitor, VCCI Phyre2 PDB 1xod chain A domain 1 Region: 54 - 112 Aligned: 57 Modelled: 59 Confidence: 29.4% Identity: 18% Fold: PH domain-like barrel Superfamily: PH domain-like Family: Enabled/VASP homology 1 domain (EVH1 domain) Phyre2 PDB 1v9y chain A Region: 55 - 115 Aligned: 55 Modelled: 61 Confidence: 21.6% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:heme pas sensor protein; PDBTitle: crystal structure of the heme pas sensor domain of ec dos (ferric2 form) Phyre2 PDB 1v9y chain A Region: 55 - 115 Aligned: 55 Modelled: 61 Confidence: 21.6% Identity: 13% Fold: Profilin-like Superfamily: PYP-like sensor domain (PAS domain) Family: Heme-binding PAS domain Phyre2 PDB 3ewk chain A Region: 55 - 119 Aligned: 55 Modelled: 65 Confidence: 21.1% Identity: 11% PDB header:flavoprotein Chain: A: PDB Molecule:sensor protein; PDBTitle: structure of the redox sensor domain of methylococcus capsulatus2 (bath) mmos Phyre2 PDB 3ajv chain A Region: 31 - 65 Aligned: 35 Modelled: 35 Confidence: 21.0% Identity: 26% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: splicing endonuclease from aeropyrum pernix Phyre2 PDB 1wa9 chain A Region: 55 - 98 Aligned: 37 Modelled: 44 Confidence: 16.2% Identity: 16% PDB header:circadian rhythm Chain: A: PDB Molecule:period circadian protein; PDBTitle: crystal structure of the pas repeat region of the2 drosophila clock protein period Phyre2 PDB 2grg chain A domain 1 Region: 51 - 68 Aligned: 18 Modelled: 18 Confidence: 13.8% Identity: 33% Fold: Profilin-like Superfamily: YNR034W-A-like Family: YNR034W-A-like Phyre2 PDB 3flj chain A Region: 54 - 71 Aligned: 18 Modelled: 18 Confidence: 13.8% Identity: 28% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein conserved in bacteria with a PDBTitle: crystal structure of uncharacterized protein conserved in bacteria2 with a cystatin-like fold (yp_168589.1) from silicibacter pomeroyi3 dss-3 at 2.00 a resolution Phyre2 PDB 2k9k chain A Region: 53 - 73 Aligned: 21 Modelled: 21 Confidence: 13.7% Identity: 19% PDB header:metal transport Chain: A: PDB Molecule:tonb2; PDBTitle: molecular characterization of the tonb2 protein from vibrio2 anguillarum Phyre2 PDB 2zyz chain A Region: 29 - 65 Aligned: 37 Modelled: 37 Confidence: 13.6% Identity: 14% PDB header:splicing Chain: A: PDB Molecule:putative uncharacterized protein pae0789; PDBTitle: pyrobaculum aerophilum splicing endonuclease Phyre2 PDB 2gsk chain B domain 1 Region: 53 - 73 Aligned: 21 Modelled: 21 Confidence: 13.4% Identity: 14% Fold: TolA/TonB C-terminal domain Superfamily: TolA/TonB C-terminal domain Family: TonB Phyre2 PDB 1ujk chain A Region: 10 - 40 Aligned: 31 Modelled: 31 Confidence: 13.3% Identity: 19% Fold: alpha-alpha superhelix Superfamily: ENTH/VHS domain Family: VHS domain Phyre2 PDB 3mjq chain B Region: 55 - 115 Aligned: 55 Modelled: 60 Confidence: 13.3% Identity: 5% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the pas domain of q24qt8_deshy protein from2 desulfitobacterium hafniense. northeast structural genomics3 consortium target dhr85c. Phyre2 PDB 1xx3 chain A Region: 53 - 73 Aligned: 21 Modelled: 21 Confidence: 11.5% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:tonb protein; PDBTitle: solution structure of escherichia coli tonb-ctd Phyre2 PDB 1u07 chain A Region: 53 - 73 Aligned: 21 Modelled: 21 Confidence: 10.4% Identity: 14% Fold: TolA/TonB C-terminal domain Superfamily: TolA/TonB C-terminal domain Family: TonB Phyre2 PDB 3bzk chain A domain 5 Region: 37 - 71 Aligned: 33 Modelled: 35 Confidence: 10.2% Identity: 27% Fold: Ribonuclease H-like motif Superfamily: Ribonuclease H-like Family: Tex RuvX-like domain-like Phyre2 PDB 3f8x chain D Region: 54 - 71 Aligned: 18 Modelled: 17 Confidence: 9.6% Identity: 28% PDB header:isomerase Chain: D: PDB Molecule:putative delta-5-3-ketosteroid isomerase; PDBTitle: crystal structure of a putative delta-5-3-ketosteroid isomerase2 (eca2236) from pectobacterium atrosepticum scri1043 at 1.55 a3 resolution Phyre2 1 c3fc7B_ 2 c3fg8B_ 3 d1cq3a_ 4 d1xoda1 5 c1v9yA_ 6 d1v9ya_ 7 c3ewkA_ 8 c3ajvA_ 9 c1wa9A_ 10 d2grga1 11 c3fljA_ 12 c2k9kA_ 13 c2zyzA_ 14 d2gskb1 15 d1ujka_ 16 c3mjqB_ 17 c1xx3A_ 18 d1u07a_ 19 d3bzka5 20 c3f8xD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3fc7B_ 48.8 9 PDB header:transferase Chain: B: PDB Molecule:htr-like protein; PDBTitle: the crystal structure of a domain of htr-like protein from haloarcula2 marismortui atcc 43049 2 c3fg8B_ 37.6 18 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein rha05790; PDBTitle: crystal structure of pas domain of rha05790 3 d1cq3a_ 32.0 26 Fold:Soluble secreted chemokine inhibitor, VCCI Superfamily:Soluble secreted chemokine inhibitor, VCCI Family:Soluble secreted chemokine inhibitor, VCCI 4 d1xoda1 29.4 18 Fold:PH domain-like barrel Superfamily:PH domain-like Family:Enabled/VASP homology 1 domain (EVH1 domain) 5 c1v9yA_ 21.6 13 PDB header:signaling protein Chain: A: PDB Molecule:heme pas sensor protein; PDBTitle: crystal structure of the heme pas sensor domain of ec dos (ferric2 form) 6 d1v9ya_ 21.6 13 Fold:Profilin-like Superfamily:PYP-like sensor domain (PAS domain) Family:Heme-binding PAS domain 7 c3ewkA_ 21.1 11 PDB header:flavoprotein Chain: A: PDB Molecule:sensor protein; PDBTitle: structure of the redox sensor domain of methylococcus capsulatus2 (bath) mmos 8 c3ajvA_ 21.0 26 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: splicing endonuclease from aeropyrum pernix 9 c1wa9A_ 16.2 16 PDB header:circadian rhythm Chain: A: PDB Molecule:period circadian protein; PDBTitle: crystal structure of the pas repeat region of the2 drosophila clock protein period 10 d2grga1 13.8 33 Fold:Profilin-like Superfamily:YNR034W-A-like Family:YNR034W-A-like 11 c3fljA_ 13.8 28 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein conserved in bacteria with a PDBTitle: crystal structure of uncharacterized protein conserved in bacteria2 with a cystatin-like fold (yp_168589.1) from silicibacter pomeroyi3 dss-3 at 2.00 a resolution 12 c2k9kA_ 13.7 19 PDB header:metal transport Chain: A: PDB Molecule:tonb2; PDBTitle: molecular characterization of the tonb2 protein from vibrio2 anguillarum 13 c2zyzA_ 13.6 14 PDB header:splicing Chain: A: PDB Molecule:putative uncharacterized protein pae0789; PDBTitle: pyrobaculum aerophilum splicing endonuclease 14 d2gskb1 13.4 14 Fold:TolA/TonB C-terminal domain Superfamily:TolA/TonB C-terminal domain Family:TonB 15 d1ujka_ 13.3 19 Fold:alpha-alpha superhelix Superfamily:ENTH/VHS domain Family:VHS domain 16 c3mjqB_ 13.3 5 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the pas domain of q24qt8_deshy protein from2 desulfitobacterium hafniense. northeast structural genomics3 consortium target dhr85c. 17 c1xx3A_ 11.5 14 PDB header:transport protein Chain: A: PDB Molecule:tonb protein; PDBTitle: solution structure of escherichia coli tonb-ctd 18 d1u07a_ 10.4 14 Fold:TolA/TonB C-terminal domain Superfamily:TolA/TonB C-terminal domain Family:TonB 19 d3bzka5 10.2 27 Fold:Ribonuclease H-like motif Superfamily:Ribonuclease H-like Family:Tex RuvX-like domain-like 20 c3f8xD_ 9.6 28 PDB header:isomerase Chain: D: PDB Molecule:putative delta-5-3-ketosteroid isomerase; PDBTitle: crystal structure of a putative delta-5-3-ketosteroid isomerase2 (eca2236) from pectobacterium atrosepticum scri1043 at 1.55 a3 resolution 21 c3mxqC_ not modelled 8.8 11 PDB header:transferase Chain: C: PDB Molecule:sensor protein; PDBTitle: crystal structure of sensory box sensor histidine kinase from vibrio2 cholerae 22 c3rheA_ not modelled 8.6 4 PDB header:oxidoreductase Chain: A: PDB Molecule:nad-dependent benzaldehyde dehydrogenase; PDBTitle: the crystal structure of nad-dependent benzaldehyde dehydrogenase from2 legionella pneumophila 23 d1ul5a_ not modelled 7.8 8 Fold:SBT domain Superfamily:SBT domain Family:SBT domain 24 d1ul4a_ not modelled 7.4 8 Fold:SBT domain Superfamily:SBT domain Family:SBT domain 25 d1mqea_ not modelled 7.2 29 Fold:Nudix Superfamily:Nudix Family:MutT-like 26 c2w4eA_ not modelled 6.7 22 PDB header:hydrolase Chain: A: PDB Molecule:mutt/nudix family protein; PDBTitle: structure of an n-terminally truncated nudix hydrolase2 dr2204 from deinococcus radiodurans 27 c2l5fA_ not modelled 6.3 13 PDB header:protein binding Chain: A: PDB Molecule:pre-mrna-processing factor 40 homolog a; PDBTitle: solution structure of the tandem ww domains from hypa/fbp11 28 c2ic6B_ not modelled 5.9 32 PDB header:viral protein Chain: B: PDB Molecule:nucleocapsid protein; PDBTitle: the coiled-coil domain (residues 1-75) structure of the sin2 nombre virus nucleocapsid protein 29 c3rtyA_ not modelled 5.9 11 PDB header:circadian clock protein Chain: A: PDB Molecule:period circadian protein; PDBTitle: structure of an enclosed dimer formed by the drosophila period protein 30 c4a1qB_ not modelled 5.9 33 PDB header:viral protein Chain: B: PDB Molecule:orf e73; PDBTitle: solution structure of e73 protein from sulfolobus spindle-2 shaped virus ragged hills, a hyperthermophilic3 crenarchaeal virus from yellowstone national park 31 c2kelB_ not modelled 5.6 18 PDB header:transcription repressor Chain: B: PDB Molecule:uncharacterized protein 56b; PDBTitle: structure of the transcription regulator svtr from the2 hyperthermophilic archaeal virus sirv1 32 d1ltqa1 not modelled 5.5 26 Fold:HAD-like Superfamily:HAD-like Family:phosphatase domain of polynucleotide kinase 33 c3kebB_ not modelled 5.5 10 PDB header:oxidoreductase Chain: B: PDB Molecule:probable thiol peroxidase; PDBTitle: thiol peroxidase from chromobacterium violaceum 34 c2jt1A_ not modelled 5.4 16 PDB header:transcription Chain: A: PDB Molecule:pefi protein; PDBTitle: solution nmr structure of pefi (plasmid-encoded fimbriae regulatory)2 protein from salmonella typhimurium. northeast structural genomics3 target str82 35 c3euhF_ not modelled 5.3 26 PDB header:cell cycle Chain: F: PDB Molecule:muke; PDBTitle: crystal structure of the muke-mukf complex 36 c3ak5B_ not modelled 5.3 21 PDB header:hydrolase Chain: B: PDB Molecule:hemoglobin-binding protease hbp; PDBTitle: hemoglobin protease (hbp) passenger missing domain-2 37 c3doaA_ not modelled 5.2 18 PDB header:protein binding Chain: A: PDB Molecule:fibrinogen binding protein; PDBTitle: the crystal structure of the fibrinogen binding protein from2 staphylococcus aureus 38 c2qhkA_ not modelled 5.1 23 PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of methyl-accepting chemotaxis protein from vibrio2 parahaemolyticus rimd 2210633 39 c3rj1P_ not modelled 5.1 0 PDB header:transcription Chain: P: PDB Molecule:mediator of rna polymerase ii transcription subunit 17; PDBTitle: architecture of the mediator head module

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Transmembrane helix prediction

Transmembrane helices have been predicted in your sequence to adopt the topology shown below

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0