Standard Mode for job manager, batch processing, Phyre alarm and other advanced options Retrieve Phyre Job Id  
Subscribe to Phyre at Google Groups
Visit Phyre at Google Groups
 Protein Homology/analogY Recognition Engine V 2.0

Register so you can log in Info icon to get access to our Expert Mode features.Info icon

One-to-One ThreadingInfo icon (which models your sequence against a user-supplied model) can now use models directly from the AlphaFold Protein Structure DatabaseInfo icon.

Please do not use "intensive mode" unless your search using "normal mode" indicates that a single model does not cover most of your sequence. Info icon

Current Phyre2 server load = 0% (normal running) Info icon

E-mail address:
Optional Job description
or upload contents of sequence file Info icon
or UniProt accession Info icon
Modelling Mode info icon
Please tick as appropriate. info icon || | |

5801966 submissions since Feb 14 2011

Other Resources

Missense3D Portal: a suite of resources for the analysis of amino acid substitutions in proteins

GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Michael Sternberg 
Terms and Conditions
Structural Biology Group logo Imperial logo
BBSRC logo
Phyre2 is part of Genome3D