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 Protein Homology/analogY Recognition Engine V 2.0


Covid-19 news

Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: read our preprint at

Position opening

If you are interested in joining the Phyre development team, please contact Prof. Michael Sternberg for further information.

Other Resources

Missense3D: Analyse structural impact of missense variants

PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper

Please do not use 'intensive mode' unless you are an experienced user and understand its pitfalls (and your search has already failed with 'normal mode'). For most users, most of the time, 'normal mode' will give you the answer you require

E-mail Address
Optional Job description
Amino Acid Sequence Info icon
  Or try the sequence finder
Modelling Mode info icon
Please tick as appropriate. info icon || | |


 Type a gene name, GI number, Uniprot code, free text etc. More..

 The following identifier types are present in the database:

UniProtKB-ACUniProtKB-IDGeneID (EntrezGene)RefSeq
GI numberPDBGO numberIPI

A search is also performed on the sequence descriptor line. Please note the list of available identifiers is not exhaustive as there are so many naming conventions in use. However, hopefully you'll find what you're looking for.

e.g. BRCA1, tafazzin homo sapiens, A0EM47

If you come across what you consider to be clear omissions from the database, please let me know: Harry Powell

Protein identifier(s):
Only search Gene Names

4304822 submissions since Feb 14 2011

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Michael Sternberg 
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Phyre2 is part of Genome3D