| ||Protein Homology/analogY Recognition Engine V 2.0|
Log in (top left-hand corner of this web page) to use our Expert Mode features, including batch job submission and One-to-One threading. Registering for this is quick and easy on our Login page .
You can use "One-to-One Threading" to model your sequence against your own in-house structures and those from the Protein Data Bank, as well as models downloaded from the AlphaFold Protein Structure Database.
If you have more than 5 or 6 sequences to model, it is easier for you (and better for everyone!) if you use "batch" processing (under Expert Mode).
Please do not use "intensive mode" unless your search using "normal mode" indicates that a single model does not cover most of your sequence. For most users, most of the time, 'normal mode' will give you the answer you require in a fraction of the time.
submissions since Feb 14 2011
Missense3D-DB: Database of missense variants or analyse the structural impact of missense variants in your own protein with Missense3D
PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants
GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.
Cambridge 2019 Workshop | Older Workshops | Phyre2 paper
Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: see David et al. "A common TMPRSS2 variant has a protective effect against severe COVID-19" Curr Res Transl Med. 2022 May;70(2):103333, https://doi.org/10.1016/j.retram.2022.103333
Phyre is now FREE for commercial users!
All images and data generated by Phyre2 are free to use in any publication with acknowledgementAccessibility Statement
|Please cite: The Phyre2 web portal for protein modeling, prediction and analysis|
|Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]|