Please do not use 'intensive mode' unless you are an experienced user and understand its pitfalls (and your search has already failed with 'normal mode'). For most users, most of the time, 'normal mode' will give you the answer you require

If you have more than 5 or 6 sequences to model, it is easier for you (and better for everyone!) if you use "batch" mode, which is available under the Expert Mode after you log in (top left of the interface). If you haven't registered for a Login, you can do so on the Login page.

Current Phyre2 server load = 12% (normal running)

E-mail Address
Optional Job description
Amino Acid Sequence
	Or try the sequence finder
Modelling Mode	Normal Intensive Test
Please tick as appropriate.	|NOT for Profit| FOR Profit (Commercial)| Other|

	Type a gene name, GI number, Uniprot code, free text etc. More..
	The following identifier types are present in the database: UniProtKB-AC UniProtKB-ID GeneID (EntrezGene) RefSeq GI number PDB GO number IPI UniRef100 UniParc PIR NCBI-taxon MIM UniGene PubMed EMBL EMBL-CDS Ensembl Ensembl_TRS Ensembl_PRO A search is also performed on the sequence descriptor line. Please note the list of available identifiers is not exhaustive as there are so many naming conventions in use. However, hopefully you'll find what you're looking for. e.g. BRCA1, tafazzin homo sapiens, A0EM47 If you come across what you consider to be clear omissions from the database, please let me know: Harry Powell
	Protein identifier(s): Only search Gene Names

4760757 submissions since Feb 14 2011

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Other Resources

Missense3D: Analyse structural impact of missense variants

PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper

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Covid-19 news

Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: read our preprint at https://doi.org/10.1101/2021.03.04.21252931

Position opening

If you are interested in joining the Phyre development team, please contact Prof. Michael Sternberg for further information.

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Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement

Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London Lawrence Kelley, Michael Sternberg   Disclaimer Terms and Conditions		Phyre2 is part of Genome3D