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| Protein Homology/analogY Recognition Engine V 2.2 | ||||||||
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| Standard Mode for job manager, batch processing, Phyre alarm and other advanced options | Retrieve Phyre Job Id |
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| Protein Homology/analogY Recognition Engine V 2.2 | ||||||||
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gives you access to our Expert Mode
features.
| We replaced the Phyre2 server on Friday 26th June 2026. While we think that everything is okay, it's possible that we need to do some fine tuning. |
| If you encounter any issues, please contact us so that we can investigate. Don't suffer in silence! |
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One-to-One Threading (which models your
sequence against a user-supplied model) can now use models directly from the AlphaFold Protein Structure Database.
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Please do not use "intensive mode" unless your search using "normal mode" indicates that a
single model does not cover most of your sequence.
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Examples of running Phyre2.2 on UniProt accession P0DV45 in
Normal,
Intensive
and
AlphaThread
modes
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6253348 submissions since Feb 14 2011
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| Missense3D Portal: | a suite of resources for the analysis of amino acid substitutions in proteins |
| GWYRE: | contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations. |
Phyre is now FREE for commercial users!
All images and data generated by Phyre2 are free to use in any publication with acknowledgement
Accessibility Statement| Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction | |||||||||
| Powell HR et al. Journal of Molecular Biology (2025) 437 168960 - 168969 DOI: https://doi.org/10.1016/j.jmb.2025.168960 | |||||||||
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