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 Protein Homology/analogY Recognition Engine V 2.0


Log in (top left-hand corner of this web page) to use our Expert Mode features, including batch job submissionInfo icon and One-to-One threadingInfo icon. Registering for this is quick and easy on our Login page Info icon.

You can use "One-to-One Threading" to model your sequence against your own in-house structures and those from the Protein Data BankInfo icon, as well as models downloaded from the AlphaFold Protein Structure DatabaseInfo icon.

If you have more than 5 or 6 sequences to model, it is easier for you (and better for everyone!) if you use "batch" processing (under Expert Mode).

Please do not use "intensive mode" unless your search using "normal mode" indicates that a single model does not cover most of your sequence. Info icon For most users, most of the time, 'normal mode' will give you the answer you require in a fraction of the time.

Current Phyre2 server load = 3% (normal running) Info icon

E-mail Address
Optional Job description
Amino Acid Sequence Info icon
  Or try the sequence finder
Modelling Mode info icon
Please tick as appropriate. info icon || | |


 Type a gene name, GI number, Uniprot code, free text etc. More..

 The following identifier types are present in the database:

UniProtKB-ACUniProtKB-IDGeneID (EntrezGene)RefSeq
GI numberPDBGO numberIPI

A search is also performed on the sequence descriptor line. Please note the list of available identifiers is not exhaustive as there are so many naming conventions in use. However, hopefully you'll find what you're looking for.

e.g. BRCA1, tafazzin homo sapiens, A0EM47

If you come across what you consider to be clear omissions from the database, please let me know: Harry Powell

Protein identifier(s):
Only search Gene Names

5349781 submissions since Feb 14 2011

Other Resources

Missense3D-DB: Database of missense variants or analyse the structural impact of missense variants in your own protein with Missense3D

PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants

GWYRE: contains modeled and experimentally determined structures of human proteins and protein complexes, annotated by phenotypic effects of genetic mutations.

Cambridge 2019 Workshop | Older Workshops | Phyre2 paper

Covid-19 news

Half of the human population has a defective TMPRSS2 protein that significantly reduces the chance of developing severe COVID-19: see David et al. "A common TMPRSS2 variant has a protective effect against severe COVID-19" Curr Res Transl Med. 2022 May;70(2):103333,

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All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Accessibility Statement
Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Michael Sternberg 
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