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 Protein Homology/analogY Recognition Engine V 2.0


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If you are interested in joining the Phyre development team, please contact Prof. Michael Sternberg for further information.

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Missense3D: Analyse structural impact of missense variants

PhyreRisk: A dynamic database to view human sequences and structures and map genetic variants

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Amino Acid Sequence
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Modelling Mode
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 Type a gene name, GI number, Uniprot code, free text etc. More..

 The following identifier types are present in the database:

UniProtKB-ACUniProtKB-IDGeneID (EntrezGene)RefSeq
GI numberPDBGO numberIPI

A search is also performed on the sequence descriptor line. Please note the list of available identifiers is not exhaustive as there are so many naming conventions in use. However, hopefully you'll find what you're looking for.

e.g. BRCA1, tafazzin homo sapiens, A0EM47

If you come across what you consider to be clear omissions from the database, please let me know: Lawrence Kelley

Protein identifier(s):
Only search Gene Names

3770064 submissions since Feb 14 2011

Phyre is now FREE for commercial users!

All images and data generated by Phyre2 are free to use in any publication with acknowledgement

Please cite: The Phyre2 web portal for protein modeling, prediction and analysis
Kelley LA et al. Nature Protocols 10, 845-858 (2015) [paper] [Citation link]
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Michael Sternberg 
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Phyre2 is part of Genome3D