PHYRE Protein Fold Recognition Server

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Protein Homology/analogY Recognition Engine V 2.2

Fold library entry viewer: c4xc8B_

Fold library id	PDB Header	Molecule	Title
c4xc8B_	PDB header: isomerase	Chain: B: PDB Molecule: methylmalonyl-coa mutase;	PDBTitle: isobutyryl-coa mutase fused with bound butyryl-coa, gdp, and mg and2 without cobalamin (apo-icmf/gdp)

Links to external resources
Added to library: Sat Feb 14 08:32:42 2015

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60 . . . . . . . . . 70

Sequence G P A N K V R F V T A A S L F D G H D A S I N I M R R I L Q S Q G C E V I H L G H N R S V Q E V V T A A L Q E D V Q G I A I S S Y Q G G H V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S S
T T
T T
S S
T
S
S S

. . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120 . . . . . . . . . 130 . . . . . . . . . 140

Sequence E Y F K Y M I D L L R E H G G E H I Q V F G G G G G V I V P D E I R E L Q A Y G V A R I Y S P E D G Q R M G L A G M I T D M A Q R C D I D L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T S
T T S S
T
S
T

. . . . . . . . . 150 . . . . . . . . . 160 . . . . . . . . . 170 . . . . . . . . . 180 . . . . . . . . . 190 . . . . . . . . . 200 . . . . . . . . . 210

Sequence T R Y A P T T L D T V V A G D R R A L A Q L I T A L E N G K A D P E L V S A L H A Q A K A A A V P V L G I T G T G G A G K S S L T D E L I R

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S
S S T T
T
S
S T T S S

. . . . . . . . . 220 . . . . . . . . . 230 . . . . . . . . . 240 . . . . . . . . . 250 . . . . . . . . . 260 . . . . . . . . . 270 . . . . . . . . . 280

Sequence R F R L D Q D D A L S I A V I S I D P S R R K S G G A L L G D R I R M N A I N H P N I F M R S L A T R E A G S E I S Q A L P D V I A A C K A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T T S
S G G G
S S
S T T
S S S
S S
T T

. . . . . . . . . 290 . . . . . . . . . 300 . . . . . . . . . 310 . . . . . . . . . 320 . . . . . . . . . 330 . . . . . . . . . 340 . . . . . . . . . 350

Sequence A R F D L V I V E T S G I G Q G D A A I V P H V D L S L Y V M T P E F G A A S Q L E K I D M L D F A D F V A I N K F D R K G A Q D A W R D V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
S S
S G G G
S
S
S S G G G G G T
G G G G T
S
T T S T T

. . . . . . . . . 360 . . . . . . . . . 370 . . . . . . . . . 380 . . . . . . . . . 390 . . . . . . . . . 400 . . . . . . . . . 410 . . . . . . . . . 420

Sequence A K Q V Q R N R E Q W H S R A E D M P V Y G T Q A S R F N D D G V T M L Y Q G L V G A L G A R G M S L K P G T L P N L E G R I S T G Q N V I

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
T T S
G G G S S
T T S T T
T T T
S S
S B
T T
S

. . . . . . . . . 430 . . . . . . . . . 440 . . . . . . . . . 450 . . . . . . . . . 460 . . . . . . . . . 470 . . . . . . . . . 480 . . . . . . . . . 490

Sequence V P P A R S R Y L A E L A D T V R A Y H R R V V A Q S K L A R E R Q Q L R A A H D M L Q G A G H E S A A L E T L A S E R D V S L G A V E R K

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S
G G G T T T T S
T S

. . . . . . . . . 500 . . . . . . . . . 510 . . . . . . . . . 520 . . . . . . . . . 530 . . . . . . . . . 540 . . . . . . . . . 550 . . . . . . . . . 560

Sequence L L A M W P Q M Q Q A Y S G D E Y V V I R T G L I S T T L S G T K I R K V V L P R F E D E G E I L K W L M R E N V P G S F P Y T A G V F A F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T S S B
B
S S
S S
S
S T T S T T
T T
S S S S

. . . . . . . . . 570 . . . . . . . . . 580 . . . . . . . . . 590 . . . . . . . . . 600 . . . . . . . . . 610 . . . . . . . . . 620 . . . . . . . . . 630

Sequence K R E G E D P T R M F A G E G D A F R T N R R F K L V S E G M E A K R L S T A F D S V T L Y G E D P H E R P D I Y G K V G N S G V S I A T L

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
S
B S T S S
S
B
T T
S S T T T T T T S B
S

. . . . . . . . . 640 . . . . . . . . . 650 . . . . . . . . . 660 . . . . . . . . . 670 . . . . . . . . . 680 . . . . . . . . . 690 . . . . . . . . . 700

Sequence E D M K V L Y D G F D L T N P S T S V S M T I N G P A P T I L A M F M N T A I D Q Q I D R F R A D N G R D P T A D E E A K I R A W V L Q N V

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T S
T T S T T
T T S S S

. . . . . . . . . 710 . . . . . . . . . 720 . . . . . . . . . 730 . . . . . . . . . 740 . . . . . . . . . 750 . . . . . . . . . 760 . . . . . . . . . 770

Sequence R G T V Q A D I L K E D Q G Q N T C I F S T E F S L K V M G D I Q E Y F V H H Q V R N F Y S V S I S G Y H I A E A G A N P I S Q L A F T L A

Predicted secondary structure

SS confidence

Known secondary structure (DSSP)
T T
S B
T T
S
T T

. . . . . . . . . 780 . . . . . . . . . 790 . . . . . . . . . 800 . . . . . . . . . 810 . . . . . . . . . 820 . . . . . . . . . 830 . . . . . . . . . 840

Sequence N G F T Y V E A Y L A R G M H I D D F A P N L S F F F S N G M D P E Y S V L G R V A R R I W A V T M R D K Y G A N D R S Q K L K Y H I Q T S

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
G G G
S S G G G G G T S

. . . . . . . . . 850 . . . . . . . . . 860 . . . . . . . . . 870 . . . . . . . . . 880 . . . . . . . . . 890 . . . . . . . . . 900 . . . . . . . . . 910

Sequence G R S L H A Q E I D F N D I R T T L Q A L I A I Y D N C N S L H T N A Y D E A I T T P T A E S V R R A L A I Q L I I N R E W G V A K C E N P

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) S T T
S S S G G G T T
S
T T T T S S
T T T
S G G G S S
T

. . . . . . . . . 920 . . . . . . . . . 930 . . . . . . . . . 940 . . . . . . . . . 950 . . . . . . . . . 960 . . . . . . . . . 970 . . . . . . . . . 980

Sequence N Q G S F L I E E L T D L V E E A V L Q E F E R I A E R G G V L G A M E T G Y Q R G K I Q E E S L Y Y E Q L K H D G T L P I I G V N T F R N

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T
T T T T T T S S
B T T T B S

. . . . . . . . . 990 . . . . . . . . . 1000 . . . . . . . . . 1010 . . . . . . . . . 1020 . . . . . . . . . 1030 . . . . . . . . . 1040 . . . . . . . . . 1050

Sequence P N G D P L A R S S E D E K Q S Q L H R L T E F H G A H Q A D A E A M L A R L R Q A V I D N R N V F A V L M D A V R V C S L G Q I T H A L F

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T
S
T T T T T
T T T S

. . . . . . . . . 1060

Sequence E V G G Q Y R R N M

Predicted secondary structure

SS confidence

Known secondary structure (DSSP) T T T B

Download: PDB structure FASTA sequence
Hidden Markov model

Image coloured by rainbow N → C terminus

Interactive 3D view in JSmol

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Accessibility Statement

Please cite: Phyre2.2: A Community Resource for Template-based Protein Structure Prediction

Powell HR et al. Journal of Molecular Biology (2025) in press DOI: https://doi.org/10.1016/j.jmb.2025.168960

© Structural Bioinformatics Group, Imperial College, London

Michael Sternberg

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	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70
Sequence	G	P	A	N	K	V	R	F	V	T	A	A	S	L	F	D	G	H	D	A	S	I	N	I	M	R	R	I	L	Q	S	Q	G	C	E	V	I	H	L	G	H	N	R	S	V	Q	E	V	V	T	A	A	L	Q	E	D	V	Q	G	I	A	I	S	S	Y	Q	G	G	H	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)			S	S										T	T																	T	T								S	S														T		S								S	S
	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140
Sequence	E	Y	F	K	Y	M	I	D	L	L	R	E	H	G	G	E	H	I	Q	V	F	G	G	G	G	G	V	I	V	P	D	E	I	R	E	L	Q	A	Y	G	V	A	R	I	Y	S	P	E	D	G	Q	R	M	G	L	A	G	M	I	T	D	M	A	Q	R	C	D	I	D	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)													T	T		T	T	S							T	T	S	S												T		S																								T
	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
Sequence	T	R	Y	A	P	T	T	L	D	T	V	V	A	G	D	R	R	A	L	A	Q	L	I	T	A	L	E	N	G	K	A	D	P	E	L	V	S	A	L	H	A	Q	A	K	A	A	A	V	P	V	L	G	I	T	G	T	G	G	A	G	K	S	S	L	T	D	E	L	I	R
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	S	S		S	S	T						T															T		S																									S	T	T	S	S
	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280
Sequence	R	F	R	L	D	Q	D	D	A	L	S	I	A	V	I	S	I	D	P	S	R	R	K	S	G	G	A	L	L	G	D	R	I	R	M	N	A	I	N	H	P	N	I	F	M	R	S	L	A	T	R	E	A	G	S	E	I	S	Q	A	L	P	D	V	I	A	A	C	K	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T														T	T	T	S						S	G	G	G		S	S			S	T	T										S	S	S		S	S		T	T
	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350
Sequence	A	R	F	D	L	V	I	V	E	T	S	G	I	G	Q	G	D	A	A	I	V	P	H	V	D	L	S	L	Y	V	M	T	P	E	F	G	A	A	S	Q	L	E	K	I	D	M	L	D	F	A	D	F	V	A	I	N	K	F	D	R	K	G	A	Q	D	A	W	R	D	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T		S											S	S				S	G	G	G		S								S			S	S	G	G	G	G	G	T		G	G	G	G	T		S							T	T	S	T	T
	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence	A	K	Q	V	Q	R	N	R	E	Q	W	H	S	R	A	E	D	M	P	V	Y	G	T	Q	A	S	R	F	N	D	D	G	V	T	M	L	Y	Q	G	L	V	G	A	L	G	A	R	G	M	S	L	K	P	G	T	L	P	N	L	E	G	R	I	S	T	G	Q	N	V	I
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)								T	T		T	T	S		G	G	G	S	S						T	T	S	T	T																	T	T	T							S	S						S	B				T	T		S
	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490
Sequence	V	P	P	A	R	S	R	Y	L	A	E	L	A	D	T	V	R	A	Y	H	R	R	V	V	A	Q	S	K	L	A	R	E	R	Q	Q	L	R	A	A	H	D	M	L	Q	G	A	G	H	E	S	A	A	L	E	T	L	A	S	E	R	D	V	S	L	G	A	V	E	R	K
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S		G	G	G	T	T																																						T	T	S				T													S
	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560
Sequence	L	L	A	M	W	P	Q	M	Q	Q	A	Y	S	G	D	E	Y	V	V	I	R	T	G	L	I	S	T	T	L	S	G	T	K	I	R	K	V	V	L	P	R	F	E	D	E	G	E	I	L	K	W	L	M	R	E	N	V	P	G	S	F	P	Y	T	A	G	V	F	A	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T	S	S	B							B						S	S						S	S																		S		S	T	T	S	T	T		T	T		S	S	S	S
	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630
Sequence	K	R	E	G	E	D	P	T	R	M	F	A	G	E	G	D	A	F	R	T	N	R	R	F	K	L	V	S	E	G	M	E	A	K	R	L	S	T	A	F	D	S	V	T	L	Y	G	E	D	P	H	E	R	P	D	I	Y	G	K	V	G	N	S	G	V	S	I	A	T	L
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)				S											B	S												T	S	S		S								B						T	T					S	S					T	T	T	T	T	T	S	B				S
	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700
Sequence	E	D	M	K	V	L	Y	D	G	F	D	L	T	N	P	S	T	S	V	S	M	T	I	N	G	P	A	P	T	I	L	A	M	F	M	N	T	A	I	D	Q	Q	I	D	R	F	R	A	D	N	G	R	D	P	T	A	D	E	E	A	K	I	R	A	W	V	L	Q	N	V
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)							T	T	T	S		T	T	S	T	T									T	T																								S	S	S
	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770
Sequence	R	G	T	V	Q	A	D	I	L	K	E	D	Q	G	Q	N	T	C	I	F	S	T	E	F	S	L	K	V	M	G	D	I	Q	E	Y	F	V	H	H	Q	V	R	N	F	Y	S	V	S	I	S	G	Y	H	I	A	E	A	G	A	N	P	I	S	Q	L	A	F	T	L	A
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)														T	T				S	B																			T	T			S														T	T
	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840
Sequence	N	G	F	T	Y	V	E	A	Y	L	A	R	G	M	H	I	D	D	F	A	P	N	L	S	F	F	F	S	N	G	M	D	P	E	Y	S	V	L	G	R	V	A	R	R	I	W	A	V	T	M	R	D	K	Y	G	A	N	D	R	S	Q	K	L	K	Y	H	I	Q	T	S
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)												T	T							G	G	G									S	S	G	G	G	G	G																T	S
	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910
Sequence	G	R	S	L	H	A	Q	E	I	D	F	N	D	I	R	T	T	L	Q	A	L	I	A	I	Y	D	N	C	N	S	L	H	T	N	A	Y	D	E	A	I	T	T	P	T	A	E	S	V	R	R	A	L	A	I	Q	L	I	I	N	R	E	W	G	V	A	K	C	E	N	P
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	S	T	T			S	S	S	G	G	G															T	T		S							T	T	T	T	S	S				T	T															T		S	G	G	G	S	S		T
	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980
Sequence	N	Q	G	S	F	L	I	E	E	L	T	D	L	V	E	E	A	V	L	Q	E	F	E	R	I	A	E	R	G	G	V	L	G	A	M	E	T	G	Y	Q	R	G	K	I	Q	E	E	S	L	Y	Y	E	Q	L	K	H	D	G	T	L	P	I	I	G	V	N	T	F	R	N
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T	T																								T	T	T								T	T																				T	S	S			B	T	T	T	B	S
	.	.	.	.	.	.	.	.	.	990	.	.	.	.	.	.	.	.	.	1000	.	.	.	.	.	.	.	.	.	1010	.	.	.	.	.	.	.	.	.	1020	.	.	.	.	.	.	.	.	.	1030	.	.	.	.	.	.	.	.	.	1040	.	.	.	.	.	.	.	.	.	1050
Sequence	P	N	G	D	P	L	A	R	S	S	E	D	E	K	Q	S	Q	L	H	R	L	T	E	F	H	G	A	H	Q	A	D	A	E	A	M	L	A	R	L	R	Q	A	V	I	D	N	R	N	V	F	A	V	L	M	D	A	V	R	V	C	S	L	G	Q	I	T	H	A	L	F
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)	T	T							S																			T	T	T															T	T											T	T	T	S
	.	.	.	.	.	.	.	.	.	1060
Sequence	E	V	G	G	Q	Y	R	R	N	M
Predicted secondary structure
SS confidence
Known secondary structure (DSSP)		T	T	T	B