Phyre 2 Results for P60647

Email	l.a.kelley@imperial.ac.uk
Description	P60647
Date	Tue Jul 17 17:05:12 BST 2012
Unique Job ID	3825143f4c5ba917

Summary

Top model

Image coloured by rainbow N → C terminus

Model (left) based on template c2kncA_

Top template information

PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Confidence and coverage

Confidence:

41.9%

Coverage:

31%

40 residues ( 31% of your sequence) have been modelled with 41.9% confidence by the single highest scoring template.

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3D viewing

Interactive 3D view in Jmol

Sequence analysis

Secondary structure and disorder prediction

1 . . . . . . . . 10 . . . . . . . . . 20 . . . . . . . . . 30 . . . . . . . . . 40 . . . . . . . . . 50 . . . . . . . . . 60

Sequence M H K V Q L I I K L L L Q L G I I I V I T Y I G T E I Q K I F H L P L A G S I V G L F L F Y L L L Q F K I V P L T W V E

Secondary structure

SS confidence

Disorder ? ? ?

Disorder confidence

. . . . . . . . . 70 . . . . . . . . . 80 . . . . . . . . . 90 . . . . . . . . . 100 . . . . . . . . . 110 . . . . . . . . . 120

Sequence D G A N F L L K T M V F F F I P S V V G I M D V A S E I T L N Y I L F F A V I I I G T C I V A L S S G Y I A E K M S V K

Secondary structure

SS confidence

Disorder

Disorder confidence

. . . . . . . . . 130 .

Sequence H K H R K G V D A Y E

Secondary structure

SS confidence

Disorder ? ? ? ? ? ? ? ? ? ? ?

Disorder confidence

Confidence Key
High(9) Low (0)

? Disordered

Alpha helix

Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank	Aligned region

PDB 2knc chain A

Region: 92 - 131
Aligned: 40
Modelled: 40
Confidence: 41.9%
Identity: 8%
PDB header:cell adhesion
Chain: A: PDB Molecule:integrin alpha-iib;
PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex

Phyre2

PDB 2kb1 chain A

Region: 96 - 127
Aligned: 32
Modelled: 32
Confidence: 35.7%
Identity: 22%
PDB header:membrane protein
Chain: A: PDB Molecule:wsk3;
PDBTitle: nmr studies of a channel protein without membrane:2 structure and dynamics of water-solubilized kcsa

Phyre2

PDB 1iwg chain A domain 8

Region: 70 - 124
Aligned: 55
Modelled: 55
Confidence: 25.1%
Identity: 5%
Fold: Multidrug efflux transporter AcrB transmembrane domain
Superfamily: Multidrug efflux transporter AcrB transmembrane domain
Family: Multidrug efflux transporter AcrB transmembrane domain

Phyre2

PDB 3iz5 chain D

Region: 115 - 131
Aligned: 17
Modelled: 17
Confidence: 20.5%
Identity: 29%
PDB header:ribosome
Chain: D: PDB Molecule:60s ribosomal protein l4 (l4p);
PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome

Phyre2

PDB 1fft chain B domain 2

Region: 89 - 131
Aligned: 43
Modelled: 43
Confidence: 18.3%
Identity: 7%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 1oy8 chain A

Region: 74 - 124
Aligned: 51
Modelled: 51
Confidence: 14.1%
Identity: 6%
PDB header:membrane protein
Chain: A: PDB Molecule:acriflavine resistance protein b;
PDBTitle: structural basis of multiple drug binding capacity of the acrb2 multidrug efflux pump

Phyre2

PDB 3qnq chain D

Region: 93 - 131
Aligned: 39
Modelled: 39
Confidence: 11.9%
Identity: 5%
PDB header:membrane protein, transport protein
Chain: D: PDB Molecule:pts system, cellobiose-specific iic component;
PDBTitle: crystal structure of the transporter chbc, the iic component from the2 n,n'-diacetylchitobiose-specific phosphotransferase system

Phyre2

PDB 1kpl chain A

Region: 90 - 129
Aligned: 40
Modelled: 40
Confidence: 10.1%
Identity: 5%
Fold: Clc chloride channel
Superfamily: Clc chloride channel
Family: Clc chloride channel

Phyre2

PDB 1j9i chain A

Region: 106 - 131
Aligned: 26
Modelled: 26
Confidence: 10.0%
Identity: 15%
Fold: Putative DNA-binding domain
Superfamily: Putative DNA-binding domain
Family: Terminase gpNU1 subunit domain

Phyre2

PDB 1r3j chain C

Region: 96 - 127
Aligned: 32
Modelled: 32
Confidence: 9.2%
Identity: 19%
Fold: Voltage-gated potassium channels
Superfamily: Voltage-gated potassium channels
Family: Voltage-gated potassium channels

Phyre2

PDB 3dtu chain B domain 2

Region: 97 - 130
Aligned: 34
Modelled: 34
Confidence: 9.0%
Identity: 21%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 3ehb chain B domain 2

Region: 97 - 130
Aligned: 34
Modelled: 34
Confidence: 8.9%
Identity: 15%
Fold: Transmembrane helix hairpin
Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region
Family: Cytochrome c oxidase subunit II-like, transmembrane region

Phyre2

PDB 1vek chain A

Region: 59 - 70
Aligned: 12
Modelled: 12
Confidence: 7.0%
Identity: 50%
Fold: RuvA C-terminal domain-like
Superfamily: UBA-like
Family: UBA domain

Phyre2

PDB 2l2t chain A

Region: 94 - 126
Aligned: 33
Modelled: 33
Confidence: 6.1%
Identity: 15%
PDB header:membrane protein
Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4;
PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain

Phyre2

PDB 2lor chain A

Region: 93 - 121
Aligned: 29
Modelled: 29
Confidence: 5.1%
Identity: 10%
PDB header:membrane protein
Chain: A: PDB Molecule:transmembrane protein 141;
PDBTitle: backbone structure of human membrane protein tmem141

Phyre2

	1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence	M	H	K	V	Q	L	I	I	K	L	L	L	Q	L	G	I	I	I	V	I	T	Y	I	G	T	E	I	Q	K	I	F	H	L	P	L	A	G	S	I	V	G	L	F	L	F	Y	L	L	L	Q	F	K	I	V	P	L	T	W	V	E
Secondary structure
SS confidence
Disorder	?	?	?
Disorder confidence

	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence	D	G	A	N	F	L	L	K	T	M	V	F	F	F	I	P	S	V	V	G	I	M	D	V	A	S	E	I	T	L	N	Y	I	L	F	F	A	V	I	I	I	G	T	C	I	V	A	L	S	S	G	Y	I	A	E	K	M	S	V	K
Secondary structure
SS confidence
Disorder
Disorder confidence

	.	.	.	.	.	.	.	.	.	130	.
Sequence	H	K	H	R	K	G	V	D	A	Y	E
Secondary structure
SS confidence
Disorder	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence