|   |
80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
S | Q | K | K | Q | D | I | L | E | A | I | R | D | H | Q | V | V | I | V | A | G | E | T | G | S | G | K | T | T | Q | L | P | K | I | C | M | E | L | G | R | G | I | K | G | L | I | G | H | T | Q | P | R | R | L | A | A | R | T | V | A | N | R | I | A | E | E | L | K | T | E | P | G | G | C | I | G | Y | K | V | R |
Query Conservation |   |
  |   |   |
|   |
|
|
|   |
|
|   |   |
|
|
|
|
|
|   |
|
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|
|   |
|   |   |   |   |
|   |
|   |   |
|
|
|
|
|
|
|
|   |
|
|
|   |
|
|
|   |
|
|
|   |   |
|
|   |   |
|
|
|   |
|
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
|   |   |
|   |   |   |
|   |   |   |
|   |   |   |   |   |
|
|   |   |
|
|
|
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |
|   |   |   |
|   |   |
|   |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |
Template Sequence |   |
H | W | Y | Q | K | D | A | V | F | E | G | L | V | N | R | R | R | I | L | N | L | P | T | S | A | G | R | S | L | I | Q | A | L | L | A | R | Y | Y | L | E | N | Y | E | G | K | I | L | I | I | V | P | T | T | A | L | T | T | Q | M | A | D | D | F | . |
V | D | Y | R | L | F | S | H | A | M | I | K | K | I | G | G |
Template Known Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |  |  | S |  |  |  |  |  |
|
| S | T | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
| S | S |  |  |  |  |  |  | S | S |  |  |  |  |  |  |  |  |  |  |  | . |  |  | T | T | S | S |
| G | G | G |  |  |  |
| G | G |
Template Predicted Secondary structure |   |
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  | . |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
115 | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | |
. | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . |
  |
  |   |
|
|
|
160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | |
|
|
|
Predicted Secondary structure |   |
. | . | . |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |  |
|
|
|
| . | . | . | . |
Query SS confidence |   |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
Query Sequence |   |
. |
. |
. |
F | S | D | H | V | S | D | N | T | M | V | K | L | M | T | D | G | I | L | L | A | E | I | Q | Q | D | R | L | L | M | Q | Y | D | T | I | I | I | D | E | A | H | E | R | S | L | N | I | D | F | L | L | G | Y | L | K | E | L | L | P | R | R | P | D | L | K | I | I | I | T | S | A | T | I | . |
. |
. |
. |
Query Conservation |   |
. | . | . |
|
|   |   |   |
|   |   |
|   |
|   |   |   |
|
|
|
|
|
|
|
|
|   |   |
|
|   |
|   |   |
|
|   |
|
|
|
|
|
|
|
|
|
|
|   |
|
|   |
|
|   |
|
|
|   |
|
|   |   |
|   |
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
Alig confidence |   |
. | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |
|   |   |   |   |   |   | . | . |   |   |   |   |   |   |   |
|
|   |
|
|   |
|   |   |   |   |   |   | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|
|
|
|   |   |   |   |
Template Sequence |   |
G | A | S | K | D | D | K | Y | K | N | D | A | P | V | V | V | G | T | W | Q | T | V | V | K | Q | P | K | E | . |
. |
W | F | S | Q | F | G | M | M | M | N | D | E | C | H | L | A | T | G | K | S | . |
. |
. |
. |
. |
I | S | S | I | I | S | G | L | N | N | C | M | F | K | F | G | L | S | G | S | L | R | D | G | K |
Template Known Secondary structure |   |
G |
|
| T | T | G | G | G |
| T | T |
| S |  |  |  |  |  |  |  |  |  | T | T | S |
| G | G | . | . | G | G | G | G |  |  |  |  |  |  |  | T | G | G | G |
|
|  |  |  | . | . | . | . | . |  |  |  |  | G | G | G |
| T | T |
|
|  |  |  |  |  |  | S |
| G | G | G |
| S |
Template Predicted Secondary structure |   |
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |
|  |  |  |  |  |
|
|  |  |  | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  | . | . | . | . | . |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
194 | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | |
|
. | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . | |
|
|
|
|
. | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . |
  |
  |   |
|
233 | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
. |
|  |  |  |  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |
|
Query SS confidence |   |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
. |
D | P | E | R | F | S | R | H | F | N | N | A | P | I | I | E | V | S | G | R | T | Y | P | V | E | V | R | Y | R | P | I | V | E | E | A | D | D | T | E | R | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
D | Q | L | Q | A | I | F | D | A | V | D | E | L | S | Q | E | S | H | G | D | I | L | I | F | M |
Query Conservation |   |
. |
|   |
|   |
|   |   |
|
|   |   |
|
|
|
|   |
|   |
|
|   |
|
|
|
|
|   |
|   |
|   |   |   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|   |   |   |   |
|   |   |   |
|   |   |
|   |   |   |   |   |
|
|
|
|
|
|
|
Alig confidence |   |
. |
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |
Template Sequence |   |
A | N | I | M | Q | Y | V | G | M | F | G | . |
E | I | F | K | P | V | T | T | S | E | L | K | I | N | S | I | F | L | R | Y | P | D | E | F | T | T | K | L | K | G | K | T | Y | Q | E | E | I | K | I | I | T | G | L | S | K | R | N | K | W | I | A | K | L | A | I | K | L | A | Q | K | D | E | N | A | F | V | M | F |
Template Known Secondary structure |   |
S |
|  |  |  |  |  |  |  |  |
| . | S |  |  |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  | T | T |
|
|  |  |  |  |  |  |  |  |  | T |
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | T |
|  |  |  |  |  |  |
Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |
|
|
|
| . |
|  |  |  |  |
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
267 | . | . | 270 | . | . | . | . | . | . | . | |
. | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . |
  |
  |   |
298 | . | 300 | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | |
|
|
. | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . |
Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |
| . | . | . |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|  |  |  |  |
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
S | G | E | R | E | I | R | D | T | A | D | A | L | N | K | L | N | L | R | H | T | E | I | L | P | L | Y | A | R | L | S | N | S | E | Q | N | R | V | F | Q | . |
. |
. |
S | H | S | G | R | R | I | V | L | A | T | N | V | A | E | T | S | L | T | V | P | G | I | K | Y | V | I | D | P | G | T | A | R | I | S | R | Y |
Query Conservation |   |
|
|   |   |
|
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |
|
|
|
|
|
|   |
|
|   |   |
|
|   |   |
|
|   | . | . | . |
|   |   |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|   |
|
|
|
|
|
|
|   |
|   |   |   |
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |
|
|
|
|
|   |   |
|   |   |
|
|
|
|   |   |   |   |   |
|
|   |   |   |   |   |   | . | . | . | . |
Template Sequence |   |
K | H | V | S | H | G | K | A | I | F | D | L | I | K | N | E | . |
. |
. |
Y | D | K | V | Y | Y | V | S | G | E | V | D | T | E | T | R | N | I | M | K | T | L | A | E | N | G | K | G | I | I | I | V | A | S | Y | G | V | F | S | T | G | I | S | V | K | N | L | H | H | V | V | L | A | H | G | V | K | . |
. |
. |
. |
Template Known Secondary structure |   |
S | S |  |  |  |  |  |  |  |  |  |  |  |  | T | T | . | . | . |
| S | S |  |  |  |  | S | S | S | T | T |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| S |
|  |  |  |  |  |  |  |  |  |  |  | S |
|
|
|
| S |  |  |  |  |  |  | S | S |
|
|
| . | . | . | . |
Template Predicted Secondary structure |   |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
| . | . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
355 | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | |
|
|
. | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | |
|
|
|
  |
  |   |
375 | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . | 400 | . | . | . | . | . | . | . | |
. | . | 410 | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|  | . |  |  |  |  |
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
Query Sequence |   |
S | Y | R | T | K | V | Q | R | L | P | I | E | P | I | S | Q | A | S | A | N | Q | R | K | G | R | C | G | R | V | S | E | G | I | . |
C | I | R | L | Y | S |
Query Conservation |   |
|   |   |   |   |   |   |   |
|   |   |   |   |
|
|
|
|
|
|   |
|
|
|
|
|
|
|
|
|   |   |
|   | . |
|
|
|
|
|
|
Alig confidence |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
Template Conservation |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . |
|   |   |   |   |   |
|   |
|
|
|   |   |
|   |   |   |   |
|   |   |   |   |
|   |
|
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
S | K | I | I | V | L | Q | T | I | G | R | V | L | R | K | H | G | S | K | T | I | A | T | V | W | D |
Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . | S |
|
|  |  |  |  |  |  |  |  |  |  | T | T | T |
|
|
|
|
|
|  |  |  |  |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . | . | . | . | . | . |
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
428 | . | 430 | . | . | . | . | . | . | . | . | . | 440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . |
  |