Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	I	R	S	Y	K	N	L	N	L	V	R	A	N	I	E	T	E	S	R	Q	F	I	E	N	K	N	Y	S	I	Q	S	I	G	P	M	P	G	S	R	A	G	L	R	V	V	F	T	R	P	G	V	N	L	A	T	V	D	I
Secondary structure
SS confidence
Disorder		?	?	?	?	?																								?						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	Y	N	G	D	G	S	T	T	I	Q	Y	L	T	G	A	N	R	S	L	G	Q	E	L	A	D	H	L	F	E	T	I	N	P	A	E	F	E	Q	V	N	M	V	L	Q	G	F	V	E	T	S	V	L	P	V	L	E	L	S	A
Secondary structure
SS confidence
Disorder							?	?	?	?		?	?	?	?	?	?	?																	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		D	E	S	H	I	E	F	R	E	H	S	R	N	A	H	T	V	V	W	K	I	I	S	T	S	Y	Q	D	E	L	T	V	S	L	H	I	T	T	G	K	L	Q	I	Q	G	R	P	L	S	C	Y	R	V	F	T	F	N	L	A	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	L	D	L	Q	G	L	E	K	V	L	I	R	Q	E	D	G	K	A	N	I	V	Q	Q	E	V	A	R	T	Y	L	Q	T	V	M	A	D	A	Y	P	H	L	H	V	T	A	E	K	L	L	V	S	G	L	C	V	K	L	A	A
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?					?	?		?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	D	L	P	D	Y	C	M	L	L	Y	P	E	L	R	T	I	E	G	V	L	K	S	K	M	S	G	L	G	M	P	V	Q	Q	P	A	G	F	G	T	Y	F	D	K	P	A	A	H	Y	I	L	K	P	Q	F	A	A	T	L	R
Secondary structure
SS confidence
Disorder																												?	?	?	?	?	?	?	?	?			?																?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.
Sequence		P	E	Q	I	N	I	I	S	T	A	Y	T	F	F	N	V	E	R	H	S	L	F	H	M	E	T	V	V	D	A	S	R	M	I	S	D	M	A	R	L	M	G	K	A	T	R	A	W	G	I	I	K	D	L	Y	I	V
Secondary structure
SS confidence
Disorder																										?	?	?	?	?	?	?			?		?																		?		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2d0b chain A Region: 101 - 171 Aligned: 59 Modelled: 70 Confidence: 69.5% Identity: 17% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hiii; PDBTitle: crystal structure of bst-rnase hiii in complex with mg2+ Phyre2 PDB 1bo1 chain A Region: 245 - 321 Aligned: 76 Modelled: 77 Confidence: 57.4% Identity: 17% PDB header:transferase Chain: A: PDB Molecule:protein (phosphatidylinositol phosphate kinase PDBTitle: phosphatidylinositol phosphate kinase type ii beta Phyre2 PDB 1bo1 chain A Region: 245 - 321 Aligned: 76 Modelled: 77 Confidence: 57.4% Identity: 17% Fold: SAICAR synthase-like Superfamily: SAICAR synthase-like Family: Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta Phyre2 PDB 2gk9 chain D Region: 245 - 321 Aligned: 73 Modelled: 74 Confidence: 43.7% Identity: 15% PDB header:transferase Chain: D: PDB Molecule:phosphatidylinositol-4-phosphate 5-kinase, type PDBTitle: human phosphatidylinositol-4-phosphate 5-kinase, type ii,2 gamma Phyre2 PDB 2vap chain A domain 2 Region: 52 - 157 Aligned: 105 Modelled: 106 Confidence: 35.9% Identity: 16% Fold: Bacillus chorismate mutase-like Superfamily: Tubulin C-terminal domain-like Family: Tubulin, C-terminal domain Phyre2 PDB 1ofu chain B Region: 52 - 157 Aligned: 105 Modelled: 106 Confidence: 33.3% Identity: 17% PDB header:bacterial cell division inhibitor Chain: B: PDB Molecule:cell division protein ftsz; PDBTitle: crystal structure of sula:ftsz from pseudomonas aeruginosa Phyre2 PDB 2ix0 chain A domain 3 Region: 35 - 64 Aligned: 25 Modelled: 30 Confidence: 32.9% Identity: 32% Fold: OB-fold Superfamily: Nucleic acid-binding proteins Family: Cold shock DNA-binding domain-like Phyre2 PDB 2q1y chain B Region: 52 - 157 Aligned: 105 Modelled: 106 Confidence: 30.0% Identity: 17% PDB header:cell cycle, signaling protein Chain: B: PDB Molecule:cell division protein ftsz; PDBTitle: crystal structure of cell division protein ftsz from mycobacterium2 tuberculosis in complex with gtp-gamma-s Phyre2 PDB 2vaw chain A Region: 52 - 157 Aligned: 105 Modelled: 106 Confidence: 28.0% Identity: 17% PDB header:cell cycle Chain: A: PDB Molecule:cell division protein ftsz; PDBTitle: ftsz pseudomonas aeruginosa gdp Phyre2 PDB 2r6r chain 1 Region: 52 - 157 Aligned: 105 Modelled: 106 Confidence: 24.9% Identity: 12% PDB header:cell cycle Chain: 1: PDB Molecule:cell division protein ftsz; PDBTitle: aquifex aeolicus ftsz Phyre2 PDB 2vxy chain A Region: 52 - 157 Aligned: 99 Modelled: 106 Confidence: 22.9% Identity: 18% PDB header:cell cycle Chain: A: PDB Molecule:cell division protein ftsz; PDBTitle: the structure of ftsz from bacillus subtilis at 1.7a2 resolution Phyre2 PDB 1eyv chain A Region: 203 - 246 Aligned: 44 Modelled: 44 Confidence: 22.5% Identity: 14% Fold: NusB-like Superfamily: NusB-like Family: Antitermination factor NusB Phyre2 PDB 1eyv chain A Region: 203 - 246 Aligned: 44 Modelled: 44 Confidence: 22.5% Identity: 14% PDB header:transcription Chain: A: PDB Molecule:n-utilizing substance protein b homolog; PDBTitle: the crystal structure of nusb from mycobacterium2 tuberculosis Phyre2 PDB 2jr0 chain A Region: 203 - 246 Aligned: 44 Modelled: 44 Confidence: 19.2% Identity: 9% PDB header:transcription Chain: A: PDB Molecule:n utilization substance protein b homolog; PDBTitle: solution structure of nusb from aquifex aeolicus Phyre2 PDB 1w5f chain A domain 2 Region: 52 - 154 Aligned: 99 Modelled: 103 Confidence: 16.0% Identity: 14% Fold: Bacillus chorismate mutase-like Superfamily: Tubulin C-terminal domain-like Family: Tubulin, C-terminal domain Phyre2 PDB 1dpu chain A Region: 104 - 125 Aligned: 22 Modelled: 22 Confidence: 15.5% Identity: 23% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: C-terminal domain of RPA32 Phyre2 PDB 1dpu chain A Region: 104 - 125 Aligned: 22 Modelled: 22 Confidence: 15.5% Identity: 23% PDB header:dna binding protein Chain: A: PDB Molecule:replication protein a (rpa32) c-terminal domain; PDBTitle: solution structure of the c-terminal domain of human rpa322 complexed with ung2(73-88) Phyre2 PDB 2doa chain A domain 1 Region: 261 - 301 Aligned: 41 Modelled: 41 Confidence: 15.4% Identity: 7% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: ELL N2 domain-like Phyre2 PDB 1ey1 chain A Region: 203 - 246 Aligned: 44 Modelled: 44 Confidence: 15.2% Identity: 11% Fold: NusB-like Superfamily: NusB-like Family: Antitermination factor NusB Phyre2 PDB 3fwc chain O Region: 171 - 232 Aligned: 62 Modelled: 62 Confidence: 14.8% Identity: 18% PDB header:cell cycle, transcription Chain: O: PDB Molecule:protein sus1; PDBTitle: sac3:sus1:cdc31 complex Phyre2 1 c2d0bA_ 2 c1bo1A_ 3 d1bo1a_ 4 c2gk9D_ 5 d2vapa2 6 c1ofuB_ 7 d2ix0a3 8 c2q1yB_ 9 c2vawA_ 10 c2r6r1_ 11 c2vxyA_ 12 d1eyva_ 13 c1eyvA_ 14 c2jr0A_ 15 d1w5fa2 16 d1dpua_ 17 c1dpuA_ 18 d2doaa1 19 d1ey1a_ 20 c3fwcO_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2d0bA_ 69.5 17 PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease hiii; PDBTitle: crystal structure of bst-rnase hiii in complex with mg2+ 2 c1bo1A_ 57.4 17 PDB header:transferase Chain: A: PDB Molecule:protein (phosphatidylinositol phosphate kinase PDBTitle: phosphatidylinositol phosphate kinase type ii beta 3 d1bo1a_ 57.4 17 Fold:SAICAR synthase-like Superfamily:SAICAR synthase-like Family:Phosphatidylinositol phosphate kinase IIbeta, PIPK IIbeta 4 c2gk9D_ 43.7 15 PDB header:transferase Chain: D: PDB Molecule:phosphatidylinositol-4-phosphate 5-kinase, type PDBTitle: human phosphatidylinositol-4-phosphate 5-kinase, type ii,2 gamma 5 d2vapa2 35.9 16 Fold:Bacillus chorismate mutase-like Superfamily:Tubulin C-terminal domain-like Family:Tubulin, C-terminal domain 6 c1ofuB_ 33.3 17 PDB header:bacterial cell division inhibitor Chain: B: PDB Molecule:cell division protein ftsz; PDBTitle: crystal structure of sula:ftsz from pseudomonas aeruginosa 7 d2ix0a3 32.9 32 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 8 c2q1yB_ 30.0 17 PDB header:cell cycle, signaling protein Chain: B: PDB Molecule:cell division protein ftsz; PDBTitle: crystal structure of cell division protein ftsz from mycobacterium2 tuberculosis in complex with gtp-gamma-s 9 c2vawA_ 28.0 17 PDB header:cell cycle Chain: A: PDB Molecule:cell division protein ftsz; PDBTitle: ftsz pseudomonas aeruginosa gdp 10 c2r6r1_ 24.9 12 PDB header:cell cycle Chain: 1: PDB Molecule:cell division protein ftsz; PDBTitle: aquifex aeolicus ftsz 11 c2vxyA_ 22.9 18 PDB header:cell cycle Chain: A: PDB Molecule:cell division protein ftsz; PDBTitle: the structure of ftsz from bacillus subtilis at 1.7a2 resolution 12 d1eyva_ 22.5 14 Fold:NusB-like Superfamily:NusB-like Family:Antitermination factor NusB 13 c1eyvA_ 22.5 14 PDB header:transcription Chain: A: PDB Molecule:n-utilizing substance protein b homolog; PDBTitle: the crystal structure of nusb from mycobacterium2 tuberculosis 14 c2jr0A_ 19.2 9 PDB header:transcription Chain: A: PDB Molecule:n utilization substance protein b homolog; PDBTitle: solution structure of nusb from aquifex aeolicus 15 d1w5fa2 16.0 14 Fold:Bacillus chorismate mutase-like Superfamily:Tubulin C-terminal domain-like Family:Tubulin, C-terminal domain 16 d1dpua_ 15.5 23 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:C-terminal domain of RPA32 17 c1dpuA_ 15.5 23 PDB header:dna binding protein Chain: A: PDB Molecule:replication protein a (rpa32) c-terminal domain; PDBTitle: solution structure of the c-terminal domain of human rpa322 complexed with ung2(73-88) 18 d2doaa1 15.4 7 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:ELL N2 domain-like 19 d1ey1a_ 15.2 11 Fold:NusB-like Superfamily:NusB-like Family:Antitermination factor NusB 20 c3fwcO_ 14.8 18 PDB header:cell cycle, transcription Chain: O: PDB Molecule:protein sus1; PDBTitle: sac3:sus1:cdc31 complex 21 c2kdxA_ not modelled 14.3 9 PDB header:metal-binding protein Chain: A: PDB Molecule:hydrogenase/urease nickel incorporation protein PDBTitle: solution structure of hypa protein 22 d1tzva_ not modelled 14.1 14 Fold:NusB-like Superfamily:NusB-like Family:Antitermination factor NusB 23 c2rhoB_ not modelled 13.1 16 PDB header:cell cycle Chain: B: PDB Molecule:cell division protein ftsz; PDBTitle: synthetic gene encoded bacillus subtilis ftsz ncs dimer with2 bound gdp and gtp-gamma-s 24 c2cw1A_ not modelled 13.0 20 PDB header:de novo protein Chain: A: PDB Molecule:sn4m; PDBTitle: solution structure of the de novo-designed lambda cro fold2 protein 25 d2yt9a2 not modelled 12.9 40 Fold:beta-beta-alpha zinc fingers Superfamily:beta-beta-alpha zinc fingers Family:Classic zinc finger, C2H2 26 c3f62A_ not modelled 11.9 13 PDB header:cytokine Chain: A: PDB Molecule:interleukin 18 binding protein; PDBTitle: crystal structure of human il-18 in complex with ectromelia virus il-2 18 binding protein 27 c3al3A_ not modelled 11.6 7 PDB header:dna binding protein/protein binding Chain: A: PDB Molecule:dna topoisomerase 2-binding protein 1; PDBTitle: crystal structure of topbp1 brct7/8-bach1 peptide complex 28 d1vela_ not modelled 10.6 14 Fold:Ferritin-like Superfamily:Ferritin-like Family:Ferritin 29 d2bbya_ not modelled 10.2 26 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:DNA-binding domain from rap30 30 d1vh8a_ not modelled 9.9 15 Fold:Bacillus chorismate mutase-like Superfamily:IpsF-like Family:IpsF-like 31 d1vmea1 not modelled 9.8 12 Fold:Flavodoxin-like Superfamily:Flavoproteins Family:Flavodoxin-related 32 d2v4jb2 not modelled 9.2 13 Fold:Ferredoxin-like Superfamily:Nitrite/Sulfite reductase N-terminal domain-like Family:DsrA/DsrB N-terminal-domain-like 33 d1aopa2 not modelled 8.9 13 Fold:Ferredoxin-like Superfamily:Nitrite/Sulfite reductase N-terminal domain-like Family:Duplicated SiR/NiR-like domains 1 and 3 34 c2wscL_ not modelled 8.2 29 PDB header:photosynthesis Chain: L: PDB Molecule:photosystem i reaction center subunit xi, PDBTitle: improved model of plant photosystem i 35 d1zq1c2 not modelled 7.7 22 Fold:DCoH-like Superfamily:GAD domain-like Family:GAD domain 36 d1jb0l_ not modelled 7.5 36 Fold:Photosystem I reaction center subunit XI, PsaL Superfamily:Photosystem I reaction center subunit XI, PsaL Family:Photosystem I reaction center subunit XI, PsaL 37 c1w59B_ not modelled 7.2 18 PDB header:cell division Chain: B: PDB Molecule:cell division protein ftsz homolog 1; PDBTitle: ftsz dimer, empty (m. jannaschii) 38 d2cufa1 not modelled 6.8 30 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Homeodomain 39 d1sqga1 not modelled 6.7 19 Fold:NusB-like Superfamily:NusB-like Family:RmsB N-terminal domain-like 40 c3m05A_ not modelled 6.7 14 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein pepe_1480; PDBTitle: the crystal structure of a functionally unknown protein2 pepe_1480 from pediococcus pentosaceus atcc 25745 41 c3h0dB_ not modelled 6.7 32 PDB header:transcription/dna Chain: B: PDB Molecule:ctsr; PDBTitle: crystal structure of ctsr in complex with a 26bp dna duplex 42 c2kokA_ not modelled 6.6 13 PDB header:oxidoreductase Chain: A: PDB Molecule:arsenate reductase; PDBTitle: solution structure of an arsenate reductase (arsc) related protein2 from brucella melitensis. seattle structural genomics center for3 infectious disease target braba.00007.a. 43 c2v6xA_ not modelled 6.6 14 PDB header:protein transport Chain: A: PDB Molecule:vacuolar protein sorting-associated protein 4; PDBTitle: stractural insight into the interaction between escrt-iii2 and vps4 44 c2e5nA_ not modelled 6.6 17 PDB header:transcription Chain: A: PDB Molecule:rna polymerase ii elongation factor ell2; PDBTitle: solution structure of the ell_n2 domain of target of rna2 polymerase ii elongation factor ell2 45 c2da2A_ not modelled 6.5 5 PDB header:transcription Chain: A: PDB Molecule:alpha-fetoprotein enhancer binding protein; PDBTitle: solution structure of the second homeobox domain of at-2 binding transcription factor 1 (atbf1) 46 c3sb1B_ not modelled 6.2 13 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:hydrogenase expression protein; PDBTitle: hydrogenase expression protein huph from thiobacillus denitrificans2 atcc 25259 47 d2onka1 not modelled 6.1 22 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:ABC transporter ATPase domain-like 48 d2d6fc2 not modelled 6.0 20 Fold:DCoH-like Superfamily:GAD domain-like Family:GAD domain 49 d1q40b_ not modelled 5.9 12 Fold:Cystatin-like Superfamily:NTF2-like Family:NTF2-like 50 c2o01L_ not modelled 5.9 29 PDB header:photosynthesis Chain: L: PDB Molecule:photosystem i reaction center subunit xi, PDBTitle: the structure of a plant photosystem i supercomplex at 3.42 angstrom resolution 51 d2p02a3 not modelled 5.5 23 Fold:S-adenosylmethionine synthetase Superfamily:S-adenosylmethionine synthetase Family:S-adenosylmethionine synthetase 52 d2c5lc1 not modelled 5.4 16 Fold:beta-Grasp (ubiquitin-like) Superfamily:Ubiquitin-like Family:Ras-binding domain, RBD 53 c2vdwB_ not modelled 5.3 31 PDB header:transferase Chain: B: PDB Molecule:mrna-capping enzyme small subunit; PDBTitle: guanosine n7 methyl-transferase sub-complex (d1-d12) of the2 vaccinia virus mrna capping enzyme 54 c3e5aB_ not modelled 5.3 10 PDB header:transferase Chain: B: PDB Molecule:targeting protein for xklp2; PDBTitle: crystal structure of aurora a in complex with vx-680 and tpx2 55 d1qm4a3 not modelled 5.2 23 Fold:S-adenosylmethionine synthetase Superfamily:S-adenosylmethionine synthetase Family:S-adenosylmethionine synthetase 56 c2wukD_ not modelled 5.2 16 PDB header:cell cycle Chain: D: PDB Molecule:septum site-determining protein diviva; PDBTitle: diviva n-terminal domain, f17a mutant 57 c2hsbA_ not modelled 5.1 12 PDB header:unknown function Chain: A: PDB Molecule:hypothetical upf0332 protein af0298; PDBTitle: crystal structure of a hepn domain containing protein (af_0298) from2 archaeoglobus fulgidus at 1.95 a resolution 58 d1lfba_ not modelled 5.1 29 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:Homeodomain 59 d1t01a1 not modelled 5.0 14 Fold:Four-helical up-and-down bundle Superfamily:alpha-catenin/vinculin-like Family:alpha-catenin/vinculin

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

---

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0