Job Description P31828 Confidence 100.00% Date Thu Jan 5 11:48:53 GMT 2012 Rank 2 Aligned Residues 870 % Identity 14% Template c2wk3A_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:insulin degrading enzyme; PDBTitle: crystal structure of human insulin-degrading enzyme in2 complex with amyloid-beta (1-42) Resolution 2.59 Å

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		30	.	.	.		.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.
Predicted Secondary structure						.
Query SS confidence						.
Query Sequence		P	Q	D	E	.	K	L	I	T	G	Q	L	D	N	G	L	R	Y	M	I	Y	P	H	A	H	P	K	D	Q	V	N	L	W	L	Q	I	H	T	G	S	L	Q	E	E	D	N	E	L	G	V	A	H	F	V	E	H	M	M	F	N	G	T	K	T	W	P	G	N	K	V	I	E	T	F	E	S	M	G	L	R
Query Conservation						.
Alig confidence						.																							.																																										.	.	.
Template Conservation																													.																																										.	.	.
Template Sequence		P	E	D	K	R	E	Y	R	G	L	E	L	A	N	G	I	K	V	L	L	I	S	D	P	T	T	D	.	K	S	S	A	A	L	D	V	H	I	G	S	L	S	D	P	P	N	I	A	G	L	S	H	F	L	Q	H	M	L	F	L	G	T	K	K	Y	P	K	E	N	.	.	.	E	Y	S	Q	F	L	S	E
Template Known Secondary structure		T	T											T	T										T	T		S	.									S			G	G	G	S		T	T	S	T	T									G	G	G		B	S	S	S		S	T	T	.	.	.
Template Predicted Secondary structure																													.																																										.	.	.
Template SS confidence
		58	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.		.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.				.	.	.	.	130	.	.	.
		109	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		F	G	R	D	V	N	A	Y	T	S	Y	D	E	T	V	Y	Q	V	S	L	P	T	T	Q	K	Q	N	L	Q	Q	V	M	A	I	F	S	E	W	S	N	A	A	T	F	E	K	L	E	V	D	A	E	R	G	V	I	T	E	E	W	R	A	H	Q	D	A	K	W	R	T	S	Q	A	R	R	P	F	L	L	A
Query Conservation
Alig confidence																								.	.	.
Template Conservation																								.	.	.
Template Sequence		H	A	G	S	S	N	A	F	T	S	G	E	H	T	N	Y	Y	F	D	V	S	H	.	.	.	E	H	L	E	G	A	L	D	R	F	A	Q	F	F	L	S	P	L	F	D	E	S	A	K	D	R	E	V	N	A	V	D	S	E	H	E	K	N	V	M	N	D	A	W	R	L	F	Q	L	E	K	A	T	G	N
Template Known Secondary structure		T	T									S	S										G	.	.	.	G	G										G	G	G	T		B																						T	T													T	S
Template Predicted Secondary structure																								.	.	.
Template SS confidence
		134	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.				.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210
		189	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.								.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.		260
Predicted Secondary structure																						.	.	.	.	.	.	.																																																				.
Query SS confidence																						.	.	.	.	.	.	.																																																				.
Query Sequence		N	T	R	N	L	D	R	E	P	I	G	L	M	D	T	V	A	T	V	T	.	.	.	.	.	.	.	P	A	Q	L	R	Q	F	Y	Q	R	W	Y	Q	P	N	N	M	T	F	I	V	V	G	D	I	D	S	K	E	A	L	A	L	I	K	D	N	L	S	K	L	P	A	N	K	A	A	E	N	R	V	.	W
Query Conservation																						.	.	.	.	.	.	.																																																				.
Alig confidence																						.	.	.	.	.	.	.																																																				.
Template Conservation
Template Sequence		P	K	H	P	F	S	K	F	G	T	G	N	K	Y	T	L	E	T	R	P	N	Q	E	G	I	D	V	R	Q	E	L	L	K	F	H	S	A	Y	Y	S	S	N	L	M	A	V	V	V	L	G	R	E	S	L	D	D	L	T	N	L	V	V	K	L	F	S	E	V	E	N	K	N	V	P	L	P	E	F	P	E
Template Known Secondary structure		T	T	S	G	G	G	S			S							T						T	T																	G	G	G								S	S														T	T	S												S
Template Predicted Secondary structure
Template SS confidence
		211	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290
		261	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340
Predicted Secondary structure
Query SS confidence
Query Sequence		P	T	K	A	E	N	H	L	R	F	N	I	I	N	D	K	E	N	R	V	N	G	I	A	L	Y	Y	R	L	P	M	V	Q	V	N	D	E	Q	S	F	I	E	Q	A	E	W	S	M	L	V	Q	L	F	N	Q	R	L	Q	E	R	I	Q	S	G	E	L	K	T	I	S	G	G	T	A	R	S	V	K	I	A
Query Conservation
Alig confidence
Template Conservation
Template Sequence		H	P	F	Q	E	E	H	L	K	Q	L	Y	K	I	V	P	I	K	D	I	R	N	L	Y	V	T	F	P	I	P	D	L	Q	K	Y	Y	K	S	N	P	G	H	Y	L	G	H	L	I	G	H	E	G	P	G	S	L	L	S	E	L	K	S	K	G	W	V	N	T	L	V	G	G	Q	K	E	G	A	R	G	F
Template Known Secondary structure			S			G	G	G	S	S								S	S	S														G	G	G	T	T	T											T			S	T	T									T	T	S		S											T	T
Template Predicted Secondary structure
Template SS confidence
		291	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370
		341	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Predicted Secondary structure
Query SS confidence
Query Sequence		P	D	Y	Q	S	L	F	F	R	V	N	A	R	D	D	N	M	Q	D	A	A	N	A	L	M	A	E	L	A	T	I	D	Q	H	G	F	S	A	E	E	L	D	D	V	K	S	T	R	L	T	W	L	K	N	A	V	D	Q	Q	A	E	R	D	L	R	M	L	T	S	R	L	A	S	S	S	L	N	N	T	P
Query Conservation
Alig confidence																																																								.	.	.	.
Template Conservation																																																								.	.	.	.
Template Sequence		M	F	F	I	I	N	V	D	L	T	E	E	G	L	L	H	V	E	D	I	I	L	H	M	F	Q	Y	I	Q	K	L	R	A	E	G	P	Q	E	W	V	F	Q	E	L	K	D	L	N	A	V	A	F	R	F	.	.	.	.	K	D	K	E	R	P	R	G	Y	T	S	K	I	A	G	I	L	H	Y	Y	P	L
Template Known Secondary structure																T	T																																						T	.	.	.	.																	T	T	T	S		G
Template Predicted Secondary structure																																																								.	.	.	.
Template SS confidence
		371	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.					.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.
		421	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.													.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.
Predicted Secondary structure																																															.	.	.	.	.	.	.	.	.	.	.	.
Query SS confidence																																															.	.	.	.	.	.	.	.	.	.	.	.
Query Sequence		F	L	S	P	E	E	T	Y	Q	L	S	K	R	L	W	Q	Q	I	T	V	Q	S	L	A	E	K	W	Q	Q	L	R	K	N	Q	D	A	F	W	E	Q	M	V	N	N	E	.	.	.	.	.	.	.	.	.	.	.	.	V	A	A	K	K	A	L	S	P	A	A	I	L	A	L	E	K	E	Y	A	N	K	K
Query Conservation																																															.	.	.	.	.	.	.	.	.	.	.	.
Alig confidence		.	.	.	.	.																																									.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation		.	.	.	.	.
Template Sequence		.	.	.	.	.	E	E	V	L	T	A	E	Y	L	L	E	E	F	R	P	D	L	I	E	M	V	L	D	K	L	R	P	E	N	V	R	V	A	I	V	S	K	S	F	E	G	K	T	D	R	T	E	E	W	Y	G	T	Q	Y	K	Q	E	A	I	P	D	E	V	I	K	K	W	Q	N	A	D	L	N	G	K
Template Known Secondary structure		.	.	.	.	.	G	G	T	T	T	T	T	T															T	T		S	G	G	G								G	G	G	T	T							T	T	T																			T					T	T
Template Predicted Secondary structure		.	.	.	.	.
Template SS confidence
							447	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.
		489	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.		.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.
Predicted Secondary structure																																																				.
Query SS confidence																																																				.
Query Sequence		L	A	A	Y	V	F	P	G	R	N	L	S	L	T	V	D	A	D	P	Q	A	E	I	S	S	K	E	T	L	A	E	N	L	T	S	L	T	L	S	N	G	A	R	V	I	L	A	K	S	A	.	G	E	E	Q	K	L	Q	I	I	A	V	S	N	K	G	D	L	S	F	P	A	Q	Q	K	S	L	I	A	L
Query Conservation																																																				.
Alig confidence				.	.	.															.	.	.																													.
Template Conservation				.	.	.															.	.	.
Template Sequence		F	K	.	.	.	L	P	T	K	N	E	F	I	P	T	N	F	E	I	.	.	.	L	P	L	E	K	E	A	T	P	Y	P	A	L	I	K	D	T	A	M	S	K	L	W	F	K	Q	D	D	K	F	F	L	P	K	A	N	L	N	F	E	F	F	S	P	F	A	Y	V	D	P	L	H	S	N	M	A	Y	L
Template Known Secondary structure				.	.	.						T	T								.	.	.					T	T			S	S								S	S									S	S				S											G	G	G	T	S	S
Template Predicted Secondary structure				.	.	.															.	.	.
Template SS confidence
		522	.				.	.	.	.	.	.	530	.	.	.	.	.	.	.				.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.
		568	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	N	K	A	V	S	G	S	G	V	G	E	L	S	S	S	S	L	K	R	W	S	A	E	N	S	V	T	M	S	S	K	V	S	G	M	N	T	L	L	S	V	S	A	R	T	N	N	P	E	P	G	F	Q	L	I	N	Q	R	I	T	H	S	T	I	N	D	N	I	W	A	S	L	Q	N	A	Q	I	Q	A
Query Conservation
Alig confidence									.	.	.	.	.	.
Template Conservation									.	.	.	.	.	.
Template Sequence		Y	L	E	L	L	K	D	.	.	.	.	.	.	S	L	N	E	Y	A	Y	A	A	E	L	A	G	L	S	Y	D	L	Q	N	T	I	Y	G	M	Y	L	S	V	K	G	Y	N	D	K	Q	P	I	L	L	K	K	I	I	E	K	M	A	T	F	E	I	D	E	K	R	F	E	I	I	K	E	A	Y	M	R	S
Template Known Secondary structure									.	.	.	.	.	.												T	T									T	T	S									S	T	T													T	T
Template Predicted Secondary structure									.	.	.	.	.	.
Template SS confidence
		596	.	.	.	600	.	.							.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.
		648	.	650	.	.	.		.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.
Predicted Secondary structure								.
Query SS confidence								.
Query Sequence		L	K	T	L	D	Q	.	R	P	A	E	K	F	A	Q	Q	M	Y	E	T	R	Y	A	D	D	R	T	K	L	L	Q	E	N	Q	I	A	Q	F	T	A	A	D	A	L	A	A	D	R	Q	L	F	S	S	P	A	D	I	T	F	V	I	V	G	N	V	A	E	D	K	L	V	A	L	I	T	R	Y	L	G	S
Query Conservation								.
Alig confidence								.																																													.
Template Conservation																																																					.
Template Sequence		L	N	N	F	R	A	E	Q	P	H	Q	H	A	M	Y	Y	L	R	L	L	M	T	E	V	A	W	T	K	D	E	L	K	E	A	L	D	D	V	T	L	P	R	L	K	A	F	I	P	Q	L	L	.	S	R	L	H	I	E	A	L	L	H	G	N	I	T	K	Q	A	A	L	G	I	M	Q	M	V	E	D	T
Template Known Secondary structure					G	G	G	S															B	S	S												T	T															.		B										S
Template Predicted Secondary structure																																																					.
Template SS confidence
		670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720		.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.
		727	.						.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.
Predicted Secondary structure				.	.	.	.	.
Query SS confidence				.	.	.	.	.
Query Sequence		I	K	.	.	.	.	.	H	S	D	S	P	L	A	A	G	K	P	L	T	R	A	T	D	N	A	S	V	T	V	K	E	Q	N	E	P	V	A	Q	V	S	Q	W	K	R	Y	D	S	R	T	P	V	N	L	P	T	R	M	A	L	D	A	F	N	V	A	L	A	K	D	L	R	V	N	I	R	E	Q	A	S
Query Conservation				.	.	.	.	.
Alig confidence				.	.	.	.	.
Template Conservation
Template Sequence		L	I	E	H	A	H	T	K	P	L	L	P	S	Q	L	V	R	Y	R	E	V	Q	L	P	D	R	G	W	F	V	Y	Q	Q	R	N	E	V	H	N	N	S	G	I	E	I	Y	Y	Q	T	D	M	Q	S	T	S	E	N	M	F	L	E	L	F	A	Q	I	I	S	E	P	A	F	N	T	L	R	T	K	E	Q
Template Known Secondary structure									B				G	G	G						B	B				T	T										S	S		S	S																																				T	T	T	T
Template Predicted Secondary structure
Template SS confidence
		749	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.
		802	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	A	Y	S	V	S	S	R	L	S	V	D	P	Q	A	K	D	I	S	H	L	L	A	F	T	C	Q	P	E	R	H	D	E	L	L	T	L	A	N	E	V	M	V	K	R	L	A	K	G	I	S	E	Q	E	L	N	E	Y	Q	Q	N	V	Q	R	S	L	D	I	Q	Q	R	S	V	Q	Q	L	A	N	T	I
Query Conservation
Alig confidence																																																		.
Template Conservation																																																		.
Template Sequence		L	G	Y	I	V	F	S	G	P	R	R	A	N	G	I	Q	G	L	R	F	I	I	Q	S	E	K	P	P	H	Y	L	E	S	R	V	E	A	F	L	I	T	M	E	K	S	I	E	D	.	M	T	E	E	A	F	Q	K	H	I	Q	A	L	A	I	R	R	L	D	K	P	K	K	L	S	A	E	S	A	K	Y
Template Known Secondary structure				S										T	T											S	S																							.	S																					S	S
Template Predicted Secondary structure																																																		.
Template SS confidence
		829	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.		.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.
		882	.	.	.	.	.	.	.		890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.			.	920	.	.	.	.	.	.	.	.	.
Predicted Secondary structure										.																														.	.
Query SS confidence										.																														.	.
Query Sequence		V	N	S	L	I	Q	Y	D	.	D	P	A	A	W	T	E	Q	E	Q	L	L	K	Q	M	T	V	E	N	V	N	T	A	V	K	Q	Y	L	S	.	.	H	P	V	N	T	Y	T	G	V	L	L
Query Conservation										.																														.	.
Alig confidence										.																														.	.
Template Conservation
Template Sequence		W	G	E	I	I	S	Q	Q	Y	N	F	D	R	D	N	T	E	V	A	Y	L	K	T	L	T	K	E	D	I	I	K	F	Y	K	E	M	L	A	V	D	A	P	R	R	H	K	V	S	V	H	V
Template Known Secondary structure							T	T				T	T										T	T														T	S	T	T		T	T
Template Predicted Secondary structure
Template SS confidence
		908	.	910	.	.	.	.	.	.	.	.	.	920	.	.	.	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.