Return to main results Retrieve Phyre Job Id

Job DescriptionP0CB39
Confidence99.84%DateThu Jan 5 11:30:09 GMT 2012
Rank20Aligned Residues258
% Identity17%Templatec2xrgA_
PDB info PDB header:hydrolaseChain: A: PDB Molecule:ectonucleotide pyrophosphatase/phosphodiesterase family PDBTitle: crystal structure of autotaxin (enpp2) in complex with the2 ha155 boronic acid inhibitor
Resolution3.20 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   223......230.........240.........250.........260.........270.........280...... ...290.........300.
Predicted Secondary structure 







































.





Query SS confidence 































































.














Query Sequence  PPLANFKDESGNEPRTLVLVIGESTQRGRMSLYGYPRETTPELDALHKTDPNLTVFNNVVTSRP. YTIEILQQALTFANE
Query Conservation                 


 
  

         
     

 
  
         
    
 
 . 
  
    


   
Alig confidence 

































...












...










.














Template Conservation         



  

 









 


    ...  



  

  
...
      




 
 


 

 




Template Sequence  EEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGS. . . KVMPNIEKLRSCG. . . THAPYMRPVYPTKTFPNLYTLATGLYP
Template Known Secondary structure 



S



TT
SS

T

GGGGGS
T...TTSS...
S


SS
S
S
Template Predicted Secondary structure 



















...




...












Template SS confidence 















































































   149150.........160.........170.........180.. .......190..... ....200.........210.........220..
 
   302.......310 .........320.........330.........340.........350......
Predicted Secondary structure 








.........................
































Query SS confidence 








. . . . . . . . . . . . . . . . . . . . . . . . .













































Query Sequence  KNPDLYLTQ. . . . . . . . . . . . . . . . . . . . . . . . . PSLMNMMKQAGYKTFWITNQQTMTARNTMLTVFSRQTDKQYYMNQQ
Query Conservation           ......................... 

   

  

 
                                
Alig confidence 








.........................














..............................
Template Conservation    



 
   
                      



 
    
 


.............................. 
Template Sequence  ESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . T
Template Known Secondary structure  S


SSTTTT
SSSSGGG
TTS

S

TTT

B
..............................
Template Predicted Secondary structure 





























..............................
Template SS confidence 















































































   223......230.........240.........250.........260.........270. .
 
   357..360.........370....... ..380.........390.. .......400.........410.........420........
Predicted Secondary structure 







..








......

























Query SS confidence 




















. .














. . . . . .



































Query Sequence  RTQSAREYDTNVLKPFQEVLN. . DPAPKKLIIVHLLGT. . . . . . HIKYKYRYPENQGKFDGNTDHVPPGLNAEELESYND
Query Conservation          
  
       
 ..    
 
        ......
 

    
                           
Alig confidence 




















..














......





.............................
Template Conservation    



 
   


 
   
       
 

 

  


  

  

 
 .............................
Template Sequence  FFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGP. . . . . . . . . . . . . . . . . . . . . . . . . . . . . E
Template Known Secondary structure 



TTS
TTS
TTT

S
TT
G.............................G
Template Predicted Secondary structure 





















.............................
Template SS confidence 















































































   273......280.........290.........300.........310.........320.. .
 
   429430.........440.........450. ........460...
Predicted Secondary structure 

..





...........................................
Query SS confidence 






















. .











. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Sequence  YDNANLYNDHVVASLIKDFKAAN. . PNGFLVYFSDHG. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation 
   
 
 
  
  

  
    ..  



  



...........................................
Alig confidence 






















..











...........................................
Template Conservation     

  

  

 

  

  

 
 
 








  
     
 
              
    
  
     
  
Template Sequence  MTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKYDPKTIIA
Template Known Secondary structure  GTT
TTT
S




SSSGGGT
S

TT
BS


Template Predicted Secondary structure 


























Template SS confidence 















































































   324.....330.........340.........350.........360.........370.........380.........390.........400...
 
   464.....470.........480.........490.........500..
Predicted Secondary structure  .........................................























Query SS confidence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .






































Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . EEVYDTPPHKTQGRNEDNPTRHMYTIPFLLWTSEKWQAT
Query Conservation  .........................................    
       
            


 
         
Alig confidence  .........................................

















...











......
Template Conservation   
          

 
  

 
 

    

 



    

        
 



   ...  
 
 


 

......
Template Sequence  ALTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPFQGDHGFDNKV. . . NSMQTVFVGYGP. . . . . .
Template Known Secondary structure  TTSS
STT

GGGS
GGG


SSTTS
S
TT
S





S
TT
...GGG
B
SS......
Template Predicted Secondary structure 































...





......
Template SS confidence 















































































   410.........420.........430.........440.........450.........460........ .470.........480
 
   503......510.........520.........530.........540.........550......
Predicted Secondary structure 































Query SS confidence 





















































Query Sequence  HPRDFSQDVDRKYSLAELIHTWSDLAGLSYDGYDPTRSVVNPQFKETTRWIGNP
Query Conservation               
  

 



 
 

       
 

               
Alig confidence  ..



















































Template Conservation  .. 

 
    

 








 



 






   
  


 
       
Template Sequence  . . TFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMP
Template Known Secondary structure  ..SB
SS
B


GGGT



S
SS
TTTTGGGBSS







Template Predicted Secondary structure  ..






























Template SS confidence 





















































   493......500.........510.........520.........530.........540....
 
Download:Text version FASTA pairwise alignment 3D Model in PDB format

View in Jmol

Send structure to FirstGlance for more viewing options


Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
Disclaimer
Terms and Conditions