Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	L	L	N	V	P	A	G	K	D	L	P	E	D	I	Y	V	V	I	E	I	P	A	N	A	D	P	I	K	Y	E	I	D	K	E	S	G	A	L	F	V	D	R	F	M	S	T	A	M	F	Y	P	C	N	Y	G	Y	I	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		H	T	L	S	L	D	G	D	P	V	D	V	L	V	P	T	P	Y	P	L	Q	P	G	S	V	I	R	C	R	P	V	G	V	L	K	M	T	D	E	A	G	E	D	A	K	L	V	A	V	P	H	S	K	L	S	K	E	Y	D	H
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.
Sequence		I	K	D	V	N	D	L	P	E	L	L	K	A	Q	I	A	H	F	F	E	H	Y	K	D	L	E	K	G	K	W	V	K	V	E	G	W	E	N	A	E	A	A	K	A	E	I	V	A	S	F	E	R	A	K	N	K
Secondary structure
SS confidence
Disorder																																																								?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1i40 chain A Region: 2 - 176 Aligned: 175 Modelled: 175 Confidence: 100.0% Identity: 99% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 3fq3 chain H Region: 2 - 174 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 54% PDB header:hydrolase Chain: H: PDB Molecule:inorganic pyrophosphatase:bacterial/archaeal inorganic PDBTitle: crystal structure of inorganic phosphatase from brucella melitensis Phyre2 PDB 2prd chain A Region: 2 - 174 Aligned: 170 Modelled: 173 Confidence: 100.0% Identity: 48% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 3d63 chain B Region: 3 - 175 Aligned: 173 Modelled: 173 Confidence: 100.0% Identity: 61% PDB header:hydrolase Chain: B: PDB Molecule:inorganic pyrophosphatase; PDBTitle: crystal structure of inorganic pyrophosphatase from burkholderia2 pseudomallei Phyre2 PDB 1ygz chain C Region: 1 - 174 Aligned: 172 Modelled: 173 Confidence: 100.0% Identity: 46% PDB header:hydrolase Chain: C: PDB Molecule:inorganic pyrophosphatase; PDBTitle: crystal structure of inorganic pyrophosphatase from helicobacter2 pylori Phyre2 PDB 1qez chain A Region: 5 - 173 Aligned: 168 Modelled: 169 Confidence: 100.0% Identity: 53% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 1ude chain A Region: 3 - 174 Aligned: 168 Modelled: 172 Confidence: 100.0% Identity: 44% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 1twl chain A Region: 3 - 176 Aligned: 169 Modelled: 174 Confidence: 100.0% Identity: 43% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 3emj chain L Region: 15 - 172 Aligned: 158 Modelled: 158 Confidence: 100.0% Identity: 64% PDB header:hydrolase Chain: L: PDB Molecule:inorganic pyrophosphatase; PDBTitle: 2.2 a crystal structure of inorganic pyrophosphatase from2 rickettsia prowazekii (p21 form) Phyre2 PDB 2uxs chain A Region: 15 - 174 Aligned: 157 Modelled: 160 Confidence: 100.0% Identity: 46% PDB header:hydrolase Chain: A: PDB Molecule:inorganic pyrophosphatase; PDBTitle: 2.7a crystal structure of inorganic pyrophosphatase (rv3628)2 from mycobacterium tuberculosis at ph 7.5 Phyre2 PDB 1e9g chain A Region: 3 - 175 Aligned: 170 Modelled: 173 Confidence: 100.0% Identity: 25% Fold: OB-fold Superfamily: Inorganic pyrophosphatase Family: Inorganic pyrophosphatase Phyre2 PDB 3lo0 chain A Region: 4 - 170 Aligned: 156 Modelled: 167 Confidence: 100.0% Identity: 51% PDB header:hydrolase Chain: A: PDB Molecule:inorganic pyrophosphatase; PDBTitle: crystal structure of inorganic pyrophosphatase from2 ehrlichia chaffeensis Phyre2 PDB 2dhx chain A Region: 133 - 167 Aligned: 35 Modelled: 35 Confidence: 25.9% Identity: 14% PDB header:rna binding protein Chain: A: PDB Molecule:poly (adp-ribose) polymerase family, member 10 PDBTitle: solution structure of the rrm domain in the human poly (adp-2 ribose) polymerase family, member 10 variant Phyre2 PDB 1wwh chain B Region: 127 - 167 Aligned: 41 Modelled: 41 Confidence: 21.4% Identity: 12% PDB header:protein transport Chain: B: PDB Molecule:nucleoporin 35; PDBTitle: crystal structure of the mppn domain of mouse nup35 Phyre2 PDB 2yue chain A Region: 71 - 90 Aligned: 20 Modelled: 20 Confidence: 19.9% Identity: 10% PDB header:rna binding protein Chain: A: PDB Molecule:protein neuralized; PDBTitle: solution structure of the neuz (nhr) domain in neuralized2 from drosophila melanogaster Phyre2 PDB 2ghp chain A domain 1 Region: 133 - 170 Aligned: 38 Modelled: 38 Confidence: 14.0% Identity: 8% Fold: Ferredoxin-like Superfamily: RNA-binding domain, RBD Family: Canonical RBD Phyre2 PDB 3kzt chain B Region: 119 - 142 Aligned: 24 Modelled: 24 Confidence: 13.7% Identity: 21% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function (np_812423.1) from2 bacteroides thetaiotaomicron vpi-5482 at 2.10 a resolution Phyre2 PDB 1d02 chain A Region: 128 - 144 Aligned: 17 Modelled: 17 Confidence: 12.6% Identity: 24% Fold: Restriction endonuclease-like Superfamily: Restriction endonuclease-like Family: Restriction endonuclease MunI Phyre2 PDB 2o0q chain A domain 1 Region: 9 - 60 Aligned: 40 Modelled: 52 Confidence: 12.4% Identity: 15% Fold: ADP-ribosylation Superfamily: ADP-ribosylation Family: CC0527-like Phyre2 PDB 2e63 chain A Region: 71 - 91 Aligned: 21 Modelled: 21 Confidence: 11.8% Identity: 33% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa1787 protein; PDBTitle: solution structure of the neuz domain in kiaa1787 protein Phyre2 1 d1i40a_ 2 c3fq3H_ 3 d2prda_ 4 c3d63B_ 5 c1ygzC_ 6 d1qeza_ 7 d1udea_ 8 d1twla_ 9 c3emjL_ 10 c2uxsA_ 11 d1e9ga_ 12 c3lo0A_ 13 c2dhxA_ 14 c1wwhB_ 15 c2yueA_ 16 d2ghpa1 17 c3kztB_ 18 d1d02a_ 19 d2o0qa1 20 c2e63A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1i40a_ 100.0 99 Fold:OB-fold Superfamily:Inorganic pyrophosphatase Family:Inorganic pyrophosphatase 2 c3fq3H_ 100.0 54 PDB header:hydrolase Chain: H: PDB Molecule:inorganic pyrophosphatase:bacterial/archaeal inorganic PDBTitle: crystal structure of inorganic phosphatase from brucella melitensis 3 d2prda_ 100.0 48 Fold:OB-fold Superfamily:Inorganic pyrophosphatase Family:Inorganic pyrophosphatase 4 c3d63B_ 100.0 61 PDB header:hydrolase Chain: B: PDB Molecule:inorganic pyrophosphatase; PDBTitle: crystal structure of inorganic pyrophosphatase from burkholderia2 pseudomallei 5 c1ygzC_ 100.0 46 PDB header:hydrolase Chain: C: PDB Molecule:inorganic pyrophosphatase; PDBTitle: crystal structure of inorganic pyrophosphatase from helicobacter2 pylori 6 d1qeza_ 100.0 53 Fold:OB-fold Superfamily:Inorganic pyrophosphatase Family:Inorganic pyrophosphatase 7 d1udea_ 100.0 44 Fold:OB-fold Superfamily:Inorganic pyrophosphatase Family:Inorganic pyrophosphatase 8 d1twla_ 100.0 43 Fold:OB-fold Superfamily:Inorganic pyrophosphatase Family:Inorganic pyrophosphatase 9 c3emjL_ 100.0 64 PDB header:hydrolase Chain: L: PDB Molecule:inorganic pyrophosphatase; PDBTitle: 2.2 a crystal structure of inorganic pyrophosphatase from2 rickettsia prowazekii (p21 form) 10 c2uxsA_ 100.0 46 PDB header:hydrolase Chain: A: PDB Molecule:inorganic pyrophosphatase; PDBTitle: 2.7a crystal structure of inorganic pyrophosphatase (rv3628)2 from mycobacterium tuberculosis at ph 7.5 11 d1e9ga_ 100.0 25 Fold:OB-fold Superfamily:Inorganic pyrophosphatase Family:Inorganic pyrophosphatase 12 c3lo0A_ 100.0 51 PDB header:hydrolase Chain: A: PDB Molecule:inorganic pyrophosphatase; PDBTitle: crystal structure of inorganic pyrophosphatase from2 ehrlichia chaffeensis 13 c2dhxA_ 25.9 14 PDB header:rna binding protein Chain: A: PDB Molecule:poly (adp-ribose) polymerase family, member 10 PDBTitle: solution structure of the rrm domain in the human poly (adp-2 ribose) polymerase family, member 10 variant 14 c1wwhB_ 21.4 12 PDB header:protein transport Chain: B: PDB Molecule:nucleoporin 35; PDBTitle: crystal structure of the mppn domain of mouse nup35 15 c2yueA_ 19.9 10 PDB header:rna binding protein Chain: A: PDB Molecule:protein neuralized; PDBTitle: solution structure of the neuz (nhr) domain in neuralized2 from drosophila melanogaster 16 d2ghpa1 14.0 8 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 17 c3kztB_ 13.7 21 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of protein of unknown function (np_812423.1) from2 bacteroides thetaiotaomicron vpi-5482 at 2.10 a resolution 18 d1d02a_ 12.6 24 Fold:Restriction endonuclease-like Superfamily:Restriction endonuclease-like Family:Restriction endonuclease MunI 19 d2o0qa1 12.4 15 Fold:ADP-ribosylation Superfamily:ADP-ribosylation Family:CC0527-like 20 c2e63A_ 11.8 33 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa1787 protein; PDBTitle: solution structure of the neuz domain in kiaa1787 protein 21 d1go3e1 not modelled 11.3 25 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:Cold shock DNA-binding domain-like 22 d1wwha1 not modelled 11.0 12 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 23 c1p0yA_ not modelled 10.6 19 PDB header:transferase Chain: A: PDB Molecule:ribulose-1,5 bisphosphate carboxylase/oxygenase PDBTitle: crystal structure of the set domain of lsmt bound to2 melysine and adohcy 24 c2opdA_ not modelled 10.4 29 PDB header:cell adhesion Chain: A: PDB Molecule:pilx; PDBTitle: structure of the neisseria meningitidis minor type iv pilin,2 pilx 25 d1x9na2 not modelled 10.3 14 Fold:OB-fold Superfamily:Nucleic acid-binding proteins Family:DNA ligase/mRNA capping enzyme postcatalytic domain 26 c3ideD_ not modelled 8.6 26 PDB header:virus like particle Chain: D: PDB Molecule:capsid protein vp2; PDBTitle: structure of ipnv subviral particle 27 c3e9mC_ not modelled 8.2 13 PDB header:oxidoreductase Chain: C: PDB Molecule:oxidoreductase, gfo/idh/moca family; PDBTitle: crystal structure of an oxidoreductase from enterococcus2 faecalis 28 d1efva2 not modelled 7.5 13 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 29 d1q1oa_ not modelled 7.4 23 Fold:beta-Grasp (ubiquitin-like) Superfamily:CAD & PB1 domains Family:PB1 domain 30 d1wexa_ not modelled 7.2 18 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 31 c3nzlA_ not modelled 7.0 18 PDB header:transcription Chain: A: PDB Molecule:dna-binding protein satb1; PDBTitle: crystal structure of the n-terminal domain of dna-binding protein2 satb1 from homo sapiens, northeast structural genomics consortium3 target hr4435b 32 d1p9qc3 not modelled 6.9 21 Fold:Ferredoxin-like Superfamily:EF-G C-terminal domain-like Family:Hypothetical protein AF0491, C-terminal domain 33 c2jnsA_ not modelled 6.8 7 PDB header:unknown function Chain: A: PDB Molecule:bromodomain-containing protein 4; PDBTitle: solution structure of the bromodomain-containing protein 42 et domain 34 c2vtvA_ not modelled 6.5 15 PDB header:hydrolase Chain: A: PDB Molecule:phb depolymerase phaz7; PDBTitle: phaz7 depolymerase from paucimonas lemoignei 35 d1t95a3 not modelled 6.5 21 Fold:Ferredoxin-like Superfamily:EF-G C-terminal domain-like Family:Hypothetical protein AF0491, C-terminal domain 36 d3bida1 not modelled 6.3 23 Fold:YegP-like Superfamily:YegP-like Family:YegP-like 37 d2ghpa2 not modelled 6.1 20 Fold:Ferredoxin-like Superfamily:RNA-binding domain, RBD Family:Canonical RBD 38 d1efpa2 not modelled 6.0 11 Fold:DHS-like NAD/FAD-binding domain Superfamily:DHS-like NAD/FAD-binding domain Family:C-terminal domain of the electron transfer flavoprotein alpha subunit 39 d1ej7s_ not modelled 5.9 19 Fold:RuBisCO, small subunit Superfamily:RuBisCO, small subunit Family:RuBisCO, small subunit 40 d2fgea4 not modelled 5.8 14 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:MPP-like 41 d8ruci_ not modelled 5.8 10 Fold:RuBisCO, small subunit Superfamily:RuBisCO, small subunit Family:RuBisCO, small subunit 42 c2l76A_ not modelled 5.7 18 PDB header:transcription Chain: A: PDB Molecule:nfatc2-interacting protein; PDBTitle: solution nmr structure of human nfatc2ip ubiquitin-like domain,2 nfatc2ip_244_338, nesg target ht65a/ocsp target hs00387_244_338/sgc-3 toronto 43 c2df7H_ not modelled 5.5 31 PDB header:virus like particle Chain: H: PDB Molecule:structural polyprotein vp2; PDBTitle: crystal structure of infectious bursal disease virus vp2 subviral2 particle 44 d1gk8i_ not modelled 5.5 24 Fold:RuBisCO, small subunit Superfamily:RuBisCO, small subunit Family:RuBisCO, small subunit 45 d2r9ga1 not modelled 5.3 25 Fold:post-AAA+ oligomerization domain-like Superfamily:post-AAA+ oligomerization domain-like Family:MgsA/YrvN C-terminal domain-like 46 d1wdds_ not modelled 5.3 14 Fold:RuBisCO, small subunit Superfamily:RuBisCO, small subunit Family:RuBisCO, small subunit 47 c2ytcA_ not modelled 5.2 13 PDB header:transcription Chain: A: PDB Molecule:pre-mrna-splicing factor rbm22; PDBTitle: solution structure of rna binding domain in pre-mrna-2 splicing factor rbm22 48 d2df7a1 not modelled 5.2 31 Fold:Nucleoplasmin-like/VP (viral coat and capsid proteins) Superfamily:Positive stranded ssRNA viruses Family:Birnaviridae-like VP 49 d1hr6a1 not modelled 5.1 13 Fold:LuxS/MPP-like metallohydrolase Superfamily:LuxS/MPP-like metallohydrolase Family:MPP-like 50 d2pyta1 not modelled 5.1 21 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:EutQ-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0