Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	Q	V	T	S	E	Q	W	L	S	W	L	N	L	Y	F	W	P	L	L	R	V	L	A	L	I	S	T	A	P	I	L	S	E	R	S	V	P	K	R	V	K	L	G	L	A	M	M	I	T	F	A	I	A	P	S	L	P	A
Secondary structure
SS confidence
Disorder		?	?	?	?	?																												?	?	?	?	?	?	?																	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		N	D	V	P	V	F	S	F	F	A	L	W	L	A	V	Q	Q	I	L	I	G	I	A	L	G	F	T	M	Q	F	A	F	A	A	V	R	T	A	G	E	I	I	G	L	Q	M	G	L	S	F	A	T	F	V	D	P	A	S	H	L
Secondary structure
SS confidence
Disorder		?	?	?	?			?																																								?						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		N	M	P	V	L	A	R	I	M	D	M	L	A	L	L	L	F	L	T	F	N	G	H	L	W	L	I	S	L	L	V	D	T	F	H	T	L	P	I	G	G	E	P	L	N	S	N	A	F	L	A	L	T	K	A	G	S	L	I	F
Secondary structure
SS confidence
Disorder		?	?	?																																						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	N	G	L	M	L	A	L	P	L	I	T	L	L	L	T	L	N	L	A	L	G	L	L	N	R	M	A	P	Q	L	S	I	F	V	I	G	F	P	L	T	L	T	V	G	I	S	L	M	A	A	L	M	P	L	I	A	P	F	C
Secondary structure
SS confidence
Disorder																																?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.
Sequence		E	H	L	F	S	E	I	F	N	L	L	A	D	I	I	S	E	L	P	L	I
Secondary structure
SS confidence
Disorder																		?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 1r7m chain A domain 1 Region: 76 - 85 Aligned: 10 Modelled: 10 Confidence: 15.7% Identity: 40% Fold: Homing endonuclease-like Superfamily: Homing endonucleases Family: Group I mobile intron endonuclease Phyre2 PDB 2lkg chain A Region: 116 - 153 Aligned: 38 Modelled: 38 Confidence: 10.2% Identity: 11% PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor; PDBTitle: wsa major conformation Phyre2 PDB 3cm1 chain C Region: 146 - 161 Aligned: 16 Modelled: 16 Confidence: 9.2% Identity: 31% PDB header:cell cycle Chain: C: PDB Molecule:ssga-like sporulation-specific cell division protein; PDBTitle: crystal structure of ssga-like sporulation-specific cell division2 protein (yp_290167.1) from thermobifida fusca yx-er1 at 2.60 a3 resolution Phyre2 PDB 1fn9 chain A Region: 143 - 159 Aligned: 17 Modelled: 17 Confidence: 7.6% Identity: 12% Fold: Outer capsid protein sigma 3 Superfamily: Outer capsid protein sigma 3 Family: Outer capsid protein sigma 3 Phyre2 PDB 2b3g chain B Region: 1 - 14 Aligned: 14 Modelled: 14 Confidence: 7.5% Identity: 14% PDB header:replication Chain: B: PDB Molecule:cellular tumor antigen p53; PDBTitle: p53n (fragment 33-60) bound to rpa70n Phyre2 PDB 2yvx chain D Region: 73 - 140 Aligned: 67 Modelled: 68 Confidence: 6.6% Identity: 24% PDB header:transport protein Chain: D: PDB Molecule:mg2+ transporter mgte; PDBTitle: crystal structure of magnesium transporter mgte Phyre2 PDB 1qlo chain A Region: 93 - 106 Aligned: 14 Modelled: 14 Confidence: 6.3% Identity: 14% PDB header:membrane proteins Chain: A: PDB Molecule:herpes simplex virus protein icp47; PDBTitle: structure of the active domain of the herpes simplex virus2 protein icp47 in water/sodium dodecyl sulfate solution3 determined by nuclear magnetic resonance spectroscopy Phyre2 PDB 1r7m chain A Region: 76 - 85 Aligned: 10 Modelled: 10 Confidence: 6.2% Identity: 40% PDB header:hydrolase/dna Chain: A: PDB Molecule:intron-encoded endonuclease i-scei; PDBTitle: the homing endonuclease i-scei bound to its dna recognition2 region Phyre2 PDB 2kr6 chain A Region: 159 - 213 Aligned: 55 Modelled: 55 Confidence: 6.1% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:presenilin-1; PDBTitle: solution structure of presenilin-1 ctf subunit Phyre2 PDB 2zfd chain B Region: 100 - 121 Aligned: 22 Modelled: 22 Confidence: 5.7% Identity: 18% PDB header:signaling protein/transferase Chain: B: PDB Molecule:putative uncharacterized protein t20l15_90; PDBTitle: the crystal structure of plant specific calcium binding protein atcbl22 in complex with the regulatory domain of atcipk14 Phyre2 PDB 2d10 chain F Region: 205 - 212 Aligned: 8 Modelled: 8 Confidence: 5.2% Identity: 38% PDB header:cell adhesion Chain: F: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 2d10 chain G Region: 205 - 212 Aligned: 8 Modelled: 8 Confidence: 5.2% Identity: 38% PDB header:cell adhesion Chain: G: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 2d10 chain E Region: 205 - 212 Aligned: 8 Modelled: 8 Confidence: 5.2% Identity: 38% PDB header:cell adhesion Chain: E: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 PDB 2d10 chain H Region: 205 - 212 Aligned: 8 Modelled: 8 Confidence: 5.2% Identity: 38% PDB header:cell adhesion Chain: H: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide Phyre2 1 d1r7ma1 2 c2lkgA_ 3 c3cm1C_ 4 d1fn9a_ 5 c2b3gB_ 6 c2yvxD_ 7 c1qloA_ 8 c1r7mA_ 9 c2kr6A_ 10 c2zfdB_ 11 c2d10F_ 12 c2d10G_ 13 c2d10E_ 14 c2d10H_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 d1r7ma1 15.7 40 Fold:Homing endonuclease-like Superfamily:Homing endonucleases Family:Group I mobile intron endonuclease 2 c2lkgA_ 10.2 11 PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor; PDBTitle: wsa major conformation 3 c3cm1C_ 9.2 31 PDB header:cell cycle Chain: C: PDB Molecule:ssga-like sporulation-specific cell division protein; PDBTitle: crystal structure of ssga-like sporulation-specific cell division2 protein (yp_290167.1) from thermobifida fusca yx-er1 at 2.60 a3 resolution 4 d1fn9a_ 7.6 12 Fold:Outer capsid protein sigma 3 Superfamily:Outer capsid protein sigma 3 Family:Outer capsid protein sigma 3 5 c2b3gB_ 7.5 14 PDB header:replication Chain: B: PDB Molecule:cellular tumor antigen p53; PDBTitle: p53n (fragment 33-60) bound to rpa70n 6 c2yvxD_ 6.6 24 PDB header:transport protein Chain: D: PDB Molecule:mg2+ transporter mgte; PDBTitle: crystal structure of magnesium transporter mgte 7 c1qloA_ 6.3 14 PDB header:membrane proteins Chain: A: PDB Molecule:herpes simplex virus protein icp47; PDBTitle: structure of the active domain of the herpes simplex virus2 protein icp47 in water/sodium dodecyl sulfate solution3 determined by nuclear magnetic resonance spectroscopy 8 c1r7mA_ 6.2 40 PDB header:hydrolase/dna Chain: A: PDB Molecule:intron-encoded endonuclease i-scei; PDBTitle: the homing endonuclease i-scei bound to its dna recognition2 region 9 c2kr6A_ 6.1 16 PDB header:hydrolase Chain: A: PDB Molecule:presenilin-1; PDBTitle: solution structure of presenilin-1 ctf subunit 10 c2zfdB_ 5.7 18 PDB header:signaling protein/transferase Chain: B: PDB Molecule:putative uncharacterized protein t20l15_90; PDBTitle: the crystal structure of plant specific calcium binding protein atcbl22 in complex with the regulatory domain of atcipk14 11 c2d10F_ 5.2 38 PDB header:cell adhesion Chain: F: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide 12 c2d10G_ 5.2 38 PDB header:cell adhesion Chain: G: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide 13 c2d10E_ 5.2 38 PDB header:cell adhesion Chain: E: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide 14 c2d10H_ 5.2 38 PDB header:cell adhesion Chain: H: PDB Molecule:ezrin-radixin-moesin binding phosphoprotein 50; PDBTitle: crystal structure of the radixin ferm domain complexed with2 the nherf-1 c-terminal tail peptide

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0