Job Description P27253 Confidence 100.00% Date Thu Jan 5 11:43:33 GMT 2012 Rank 3 Aligned Residues 593 % Identity 27% Template c6reqB_ PDB info PDB header:isomerase Chain: B: PDB Molecule:protein (methylmalonyl-coa mutase); PDBTitle: methylmalonyl-coa mutase, 3-carboxypropyl-coa inhibitor complex Resolution 2.20 Å

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		2	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.											.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.
Predicted Secondary structure																			.	.	.	.	.	.	.	.	.	.
Query SS confidence																			.	.	.	.	.	.	.	.	.	.
Query Sequence		S	N	V	Q	E	W	Q	Q	L	A	N	K	E	L	S	R	R	.	.	.	.	.	.	.	.	.	.	E	K	T	V	D	S	L	V	H	Q	T	A	E	G	I	A	I	K	P	L	Y	T	E	A	D	L	D	N	L	E	V	T	G	T	L	P	G	L	P	P	Y	V	R	G	P	R	A	T	M	Y	T	A	Q
Query Conservation																			.	.	.	.	.	.	.	.	.	.
Alig confidence																.			.	.	.	.	.	.	.	.	.	.																													.	.	.
Template Conservation																.																																									.	.	.
Template Sequence		A	T	E	E	Q	W	E	R	E	V	E	K	V	L	.	N	R	G	R	P	P	E	K	Q	L	T	F	A	E	C	L	K	R	L	T	V	H	T	V	D	G	I	D	I	V	P	M	Y	R	P	K	D	A	P	K	.	.	.	K	L	G	Y	P	G	V	A	P	F	T	R	G	T	T	V	R	N	G	D	M	D
Template Known Secondary structure																.		T	T			T	T												T					T	T	S					S				G	G	G	S		S	.	.	.	S				T	T	S	T	T		T	T		S	S				S		S
Template Predicted Secondary structure																.																																									.	.	.
Template SS confidence
		30	.	.	.	.	.	.	.	.	.	40	.	.	.		.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.				.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.
		72	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	W	T	I	R	Q	Y	A	G	F	S	T	A	K	E	S	N	A	F	Y	R	R	N	L	A	A	G	Q	K	G	L	S	V	A	F	D	L	A	T	H	R	G	Y	D	S	D	N	P	R	V	A	G	D	V	G	K	A	G	V	A	I	D	T	V	E	D	M	K	V	L	F	D	Q	I	P	L	D	K	M	S
Query Conservation
Alig confidence																																										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation																																										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		A	W	D	V	R	A	L	H	E	D	P	D	E	K	F	T	R	K	A	I	L	E	G	L	E	R	G	V	T	S	L	L	L	R	V	D	P	D	A	I	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	A	P	E	H	L	D	E	V	L	S	D	V	L	L	E	M	T	K
Template Known Secondary structure			S									S															T	T								B	S	T	T	S	B	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.		G	G	G					T	T	T			T	T	T
Template Predicted Secondary structure																																										.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		106	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.																							.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.
		152	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.
Predicted Secondary structure
Query SS confidence
Query Sequence		V	S	M	T	M	N	G	A	V	L	P	V	L	A	F	Y	I	V	A	A	E	E	Q	G	V	T	P	D	K	L	T	G	T	I	Q	N	D	I	L	K	E	Y	L	C	R	N	T	Y	I	Y	P	P	K	P	S	M	R	I	I	A	D	I	I	A	W	C	S	G	N	M	P	R	F	N	T	I	S	I	S	G
Query Conservation
Alig confidence																																																	.	.	.	.	.
Template Conservation																																																	.	.	.	.	.
Template Sequence		V	E	V	F	S	R	Y	D	Q	G	A	A	A	E	A	L	V	S	V	Y	E	R	S	D	K	P	A	K	D	L	A	L	N	L	G	L	D	P	I	G	F	A	A	L	Q	G	T	.	.	.	.	.	E	P	D	L	T	V	L	G	D	W	V	R	R	L	A	K	F	S	P	D	S	R	A	V	T	I	D	A
Template Known Secondary structure							S	S															T		S	S		G	G	G																	T	S	.	.	.	.	.					T	T								T	S	S	S		T	T
Template Predicted Secondary structure																																																	.	.	.	.	.
Template SS confidence
		164	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210						.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.
		232	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.
Predicted Secondary structure
Query SS confidence
Query Sequence		Y	H	M	G	E	A	G	A	N	C	V	Q	Q	V	A	F	T	L	A	D	G	I	E	Y	I	K	A	A	I	S	A	G	L	K	I	D	D	F	A	P	R	L	S	F	F	F	G	I	G	M	D	L	F	M	N	V	A	M	L	R	A	A	R	Y	L	W	S	E	A	V	S	G	F	G	A	Q	D	P	K	S
Query Conservation
Alig confidence																																																																													.
Template Conservation																																																																													.
Template Sequence		N	I	Y	H	N	A	G	A	G	D	V	A	E	L	A	W	A	L	A	T	G	A	E	Y	V	R	A	L	V	E	Q	G	F	T	A	T	E	A	F	D	T	I	N	F	R	V	T	A	T	H	D	Q	F	L	T	I	A	R	L	R	A	L	R	E	A	W	A	R	I	G	E	V	F	G	V	.	D	E	D	K
Template Known Secondary structure							T	T																								T	T								T	T									S																								T		.		G	G	G
Template Predicted Secondary structure																																																																													.
Template SS confidence
		239	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.		.	.	.	.
		312	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.		.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390
Predicted Secondary structure																																																							.
Query SS confidence																																																							.
Query Sequence		L	A	L	R	T	H	C	Q	T	S	G	W	S	L	T	E	Q	D	P	Y	N	N	V	I	R	T	T	I	E	A	L	A	A	T	L	G	G	T	Q	S	L	H	T	N	A	F	D	E	A	L	G	L	P	.	T	D	F	S	A	R	I	A	R	N	T	Q	I	I	I	Q	E	E	S	E	L	C	R	T	V	D
Query Conservation																																																							.
Alig confidence																																																							.
Template Conservation
Template Sequence		R	G	A	R	Q	N	A	I	T	S	W	R	E	L	T	R	E	D	P	Y	V	N	I	L	R	G	S	I	A	T	F	S	A	S	V	G	G	A	E	S	I	T	T	L	P	F	T	Q	A	L	G	L	P	E	D	D	F	P	L	R	I	A	R	N	T	G	I	V	L	A	E	E	V	N	I	G	R	V	N	D
Template Known Secondary structure												S	T	T			S	S	S	T	T																T	T		S							T	T	T	T	T		B		S	S	S																T	S		G	G	G	S	S
Template Predicted Secondary structure
Template SS confidence
		318	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.
		391	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470
Predicted Secondary structure
Query SS confidence
Query Sequence		P	L	A	G	S	Y	Y	I	E	S	L	T	D	Q	I	V	K	Q	A	R	A	I	I	Q	Q	I	D	E	A	G	G	M	A	K	A	I	E	A	G	L	P	K	R	M	I	E	E	A	S	A	R	E	Q	S	L	I	D	Q	G	K	R	V	I	V	G	V	N	K	Y	K	L	D	H	E	D	E	T	D	V	L
Query Conservation
Alig confidence
Template Conservation
Template Sequence		P	A	G	G	S	Y	Y	V	E	S	L	T	R	S	L	A	D	A	A	W	K	E	F	Q	E	V	E	K	L	G	G	M	S	K	A	V	M	T	E	H	V	T	K	V	L	D	A	C	N	A	E	R	A	K	R	L	A	N	R	K	Q	P	I	T	A	V	S	E	F	P	M	I	G	A	R	S	I	E	T	K
Template Known Secondary structure		T	T	T	T																									T	T								S	S																			T	T	S	S			B	T	T	T	B	S			T	T							B
Template Predicted Secondary structure
Template SS confidence
		398	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.
		471	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550
Predicted Secondary structure
Query SS confidence
Query Sequence		E	I	D	N	V	M	V	R	N	E	Q	I	A	S	L	E	R	I	R	A	T	R	D	D	A	A	V	T	A	A	L	N	A	L	T	H	A	A	Q	H	N	E	N	L	L	A	A	A	V	N	A	A	R	V	R	A	T	L	G	E	I	S	D	A	L	E	V	A	F	D	R	Y	L	V	P	S	Q	C	V	T
Query Conservation
Alig confidence						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Conservation						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Sequence		P	F	P	A	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Known Secondary structure						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template Predicted Secondary structure						.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.
Template SS confidence
		478	.	480	.
		551	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.		.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																																																.
Query SS confidence																																																.
Query Sequence		G	V	I	A	Q	S	Y	H	Q	S	E	K	S	A	S	E	F	D	A	I	V	A	Q	T	E	Q	F	L	A	D	N	G	R	R	P	R	I	L	I	A	K	M	G	Q	D	G	.	H	D	R	G	A	K	V	I	A	S	A	Y	S	D	L	G	F	D	V	D	L	S	P	M	F	S	T	P	E	E	I	A	R
Query Conservation																																																.
Alig confidence		.																											.	.	.	.																.																										.
Template Conservation		.																											.	.	.	.																																										.
Template Sequence		.	A	P	A	R	K	G	L	A	W	H	R	D	S	E	V	F	E	Q	L	M	D	R	S	T	S	V	.	.	.	.	S	E	R	P	K	V	F	L	A	C	L	G	T	R	R	D	F	G	G	R	E	G	F	S	S	P	V	W	H	I	A	G	I	D	T	P	Q	V	E	G	G	.	T	T	A	E	I	V	E
Template Known Secondary structure		.					S	S						T	T													S	.	.	.	.	S	S			B							S																			T	T		B								.
Template Predicted Secondary structure		.																											.	.	.	.																																										.
Template SS confidence
			482	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.					.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.		.	550	.	.	.	.	.
		630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	A	V	E	N	D	V	H	V	V	G	A	S	S	L	A	A	G	H	K	T	L	I	P	E	L	V	E	A	L	K	K	W	G	R	E	D	I	C	V	V	A	G	G	V	I	P	P	Q	D	Y	A	F	L	Q	E	R	G	V	A	A	I	Y	G	P	G	T	P	M	L	D	S	V	R	D	V	L	N	L	I
Query Conservation
Alig confidence																																						.
Template Conservation																																						.
Template Sequence		A	F	K	K	S	G	A	Q	V	A	D	L	C	S	S	A	K	V	Y	A	Q	Q	G	L	E	V	A	K	A	L	K	A	A	G	A	K	.	A	L	Y	L	S	G	A	F	K	E	F	G	D	D	A	A	E	A	E	K	L	I	D	G	R	L	F	M	G	M	D	V	V	D	T	L	S	S	T	L	D	I	L
Template Known Secondary structure							T		S																									T	T		S	.						S		G	G	G	G	G	G	G														T	T														T
Template Predicted Secondary structure																																						.
Template SS confidence
		556	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.		.	.	.	.	.	.	.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.