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Job DescriptionP0A9U1
Confidence100.00%DateThu Jan 5 11:11:22 GMT 2012
Rank1Aligned Residues536
% Identity24%Templatec3g5uB_
PDB info PDB header:membrane proteinChain: B: PDB Molecule:multidrug resistance protein 1a; PDBTitle: structure of p-glycoprotein reveals a molecular basis for2 poly-specific drug binding
Resolution3.80 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   6...10..... ....20.........30.........40.........50.........60.........70... ......80...
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Query Sequence  ITLNGLEKRF. PGMDKPAVAPLDCTIHAGYVTGLVGPDGAGKTTLMRMLAGLLKPDSGSATVIGFDPIK. NDGALHAVLG
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Template Conservation 
                 
         
    
 
  







  
 
      
 
   
                
Template Sequence  LEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIG
Template Known Secondary structure 

SSTTS

S
TT


SSTTTTTSS

STTGGGS
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   388.390.........400.........410.........420.........430.........440.........450.........460.......
 
   84.....90.........100.........110.........120.........130...... ...140.........150..
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Query Sequence  YMPQKFGLYEDLTVMENLNLYADLRSVTGEARKQTFARLLEFTSLGPFTGRLA. . . . . . . . . . . GKLSGGMKQKLGLACT
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Template Sequence  VVSQEPVLFAT. TIAENIRYG. . . . . . REDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARA
Template Known Secondary structure  SS



SS.
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SS

TT
TTSTTGGG


SSSS
SS
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   468.470........ .480....... ..490.........500.........510.........520.........530.........540
 
   153......160.........170.........180.........190.........200.........210.........220.........230..
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Query Sequence  LVGEPKVLLLDEPGVGVDPISRRELWQMVHELAGEGMLILWSTSYLDEAEQCRDVLLMNEGELLYQGEPKALTQTMAGRS
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Template Sequence  LVRNPKILLLDEATSALDTESEAVVQAALDKARE. GRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYF
Template Known Secondary structure 

SBTT
SS
TT.SS
S
TT
S
SSS




TS
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   541........550.........560.........570.... .....580.........590.........600.........610.........
 
   233......240.........250.........260.........270........
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Query Sequence  FLMTSPHEGNRKLLQRALKLPQVSDGMIQGKSVRLILKKEATPDDI. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Template Conservation                                         
                                        
Template Sequence  KLVMTQTLDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFL
Template Known Secondary structure  T









TTT



SS
STT
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   620.........630.........640.........650.........660.........670.........680.........690.........
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation         
                   
   
   
               
 
  
   
           
   
   
Template Sequence  ILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNI
Template Known Secondary structure 

S
S

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   757..760.........770.........780.........790.........800.........810.........820.........830......
 
  
Predicted Secondary structure  ................................................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Query Conservation  ................................................................................
Template Conservation         
        
 

 
    
                               
 
 
   

            
Template Sequence  ANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMY
Template Known Secondary structure  SS
STTTT
TTTTT
SS
Template Predicted Secondary structure 
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   837..840.........850.........860.........870.........880.........890.........900.........910......
 
   279280.........290.....
Predicted Secondary structure  ...............................................................
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Query Sequence  . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . RHADGMPEININETTPR
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Template Conservation                                         
  
                           
         
Template Sequence  AQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAAAFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAK
Template Known Secondary structure 

TTTT
S
STTTSSSS
S
Template Predicted Secondary structure 





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   917..920.........930.........940.........950.........960.........970.........980.........990......
 
   296...300.........310.........320.........330......... 340.........350.........360.........370..
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Query Sequence  FEDAFIDLLGGAGTSESPLGAILHTVEGTPGETVIEAKELTKKF. . . GDFAATDHVNFAVKRGEIFGLLGPNGAGKSTTF
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Template Sequence  ATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
Template Known Secondary structure  S




SS
S




TTT





S
GGG

SS


SSS
SSSTT
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   997..1000.........1010.........1020.........1030.........1040.........1050.........1060.........1070......
 
   373......380.........390......... 400.........410.........420.........430.........440.........450.
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Query Sequence  KMMCGLLVPTSGQALVLGMDLKESSGK. ARQHLGYMAQKFSLYGNLTVEQNLRFFSGVYGLRGRAQNEKISRMSEAFGLK
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Template Sequence  QLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDC. SIAENIAYGDNSRVVS. . . . YEEIVRAAKEANIH
Template Known Secondary structure  TTSS

SSSSS
BTSS
TTS
SS



SS.BT


SS



....T
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   1077..1080.........1090.........1100.........1110.........1120. ........1130....... ..1140.........1150.
 
   452....... 460.........470.........480.........490.........500.........510.........520
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Query Sequence  SIASHATD. . . . . . . . . . . ELPLGFKQRLALACSLMHEPDILFLDEPTSGVDPLTRREFWLHINSMVEKGVTVMVTTHFM
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Template Sequence  QFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAR. EGRTCIVIAHRL
Template Known Secondary structure  SSTTTGGG
B
STTS
SS


SSS
SSS

S.SSS

S
T
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   1152.......1160.........1170.........1180.........1190.........1200.........1210........ .1220.........1230
 
   521........530.........540.........550.....
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Query Sequence  DEAEYCDRIGLVYRGKLIASGTPDDLKAQSANDEQ
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Template Conservation        
 
 

  
 
 
 
    
    
    
Template Sequence  STIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFS
Template Known Secondary structure  TGGGS
STB
S
S
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   1231........1240.........1250.........1260.....
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
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Lawrence Kelley, Benjamin Jefferys 
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