Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	L	P	P	G	P	L	L	V	L	P	V	G	A	R	V	S	R	G	G	L	S	P	T	E	R	S	C	I	S	R	H	T	Q	Q	Y	L	R	A	C	Y	P	S	G	R	Y	G	T	K	G	L	V	V	R	W	F	T	G	G	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?										?	?		?					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.
Sequence		E	P	R	G	T	D	N	E	P	S	G	N	R	S	L	E	P	H	A	W	L	T	D	V	L	T	R	L	P	E	W	P	E	E	R	L	A	E	L	L	P	L	E	G	F	T	F	F	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?		?	?																																	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3dxr chain A Region: 21 - 39 Aligned: 19 Modelled: 19 Confidence: 33.2% Identity: 26% PDB header:protein transport Chain: A: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 Phyre2 PDB 3dxr chain B Region: 19 - 39 Aligned: 21 Modelled: 21 Confidence: 32.1% Identity: 33% PDB header:protein transport Chain: B: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 Phyre2 PDB 2bsk chain A domain 1 Region: 21 - 39 Aligned: 19 Modelled: 19 Confidence: 28.1% Identity: 32% Fold: Tim10-like Superfamily: Tim10-like Family: Tim10/DDP Phyre2 PDB 3cjh chain J Region: 21 - 39 Aligned: 19 Modelled: 19 Confidence: 28.1% Identity: 32% PDB header:protein transport Chain: J: PDB Molecule:mitochondrial import inner membrane translocase subunit PDBTitle: tim8-tim13 complex Phyre2 PDB 2bsk chain D Region: 21 - 39 Aligned: 19 Modelled: 19 Confidence: 22.2% Identity: 37% PDB header:protein transport Chain: D: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the tim9 tim10 hexameric complex Phyre2 PDB 2k19 chain A Region: 53 - 94 Aligned: 31 Modelled: 42 Confidence: 21.9% Identity: 39% PDB header:antimicrobial protein Chain: A: PDB Molecule:putative piscicolin 126 immunity protein; PDBTitle: nmr solution structure of pisi Phyre2 PDB 2iqc chain A Region: 77 - 89 Aligned: 13 Modelled: 13 Confidence: 16.9% Identity: 38% PDB header:protein binding Chain: A: PDB Molecule:fanconi anemia group f protein; PDBTitle: crystal structure of human fancf protein that functions in2 the assembly of a dna damage signaling complex Phyre2 PDB 2cve chain A domain 1 Region: 51 - 58 Aligned: 8 Modelled: 8 Confidence: 14.0% Identity: 75% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: YigZ N-terminal domain-like Phyre2 PDB 2bsk chain B domain 1 Region: 19 - 39 Aligned: 21 Modelled: 21 Confidence: 12.7% Identity: 33% Fold: Tim10-like Superfamily: Tim10-like Family: Tim10/DDP Phyre2 PDB 2xgl chain B Region: 82 - 95 Aligned: 14 Modelled: 14 Confidence: 12.4% Identity: 29% PDB header:antibiotic Chain: B: PDB Molecule:colicin-m immunity protein; PDBTitle: the x-ray structure of the escherichia coli colicin m immunity2 protein demonstrates the presence of a disulphide bridge, which is3 functionally essential Phyre2 PDB 1vi7 chain A domain 1 Region: 51 - 58 Aligned: 8 Modelled: 8 Confidence: 11.1% Identity: 50% Fold: Ribosomal protein S5 domain 2-like Superfamily: Ribosomal protein S5 domain 2-like Family: YigZ N-terminal domain-like Phyre2 PDB 2inc chain C domain 1 Region: 9 - 25 Aligned: 17 Modelled: 17 Confidence: 11.1% Identity: 53% Fold: beta-Grasp (ubiquitin-like) Superfamily: TmoB-like Family: TmoB-like Phyre2 PDB 3hgk chain E Region: 28 - 42 Aligned: 15 Modelled: 15 Confidence: 11.0% Identity: 33% PDB header:transferase Chain: E: PDB Molecule:effector protein hopab2; PDBTitle: crystal structure of effect protein avrptob complexed with2 kinase pto Phyre2 PDB 3ol4 chain B Region: 35 - 44 Aligned: 10 Modelled: 10 Confidence: 11.0% Identity: 40% PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a putative uncharacterized protein from2 mycobacterium smegmatis, an ortholog of rv0543c Phyre2 PDB 1x4p chain A domain 1 Region: 15 - 29 Aligned: 15 Modelled: 15 Confidence: 10.6% Identity: 53% Fold: Surp module (SWAP domain) Superfamily: Surp module (SWAP domain) Family: Surp module (SWAP domain) Phyre2 PDB 2k48 chain A Region: 4 - 39 Aligned: 36 Modelled: 36 Confidence: 10.6% Identity: 36% PDB header:viral protein Chain: A: PDB Molecule:nucleoprotein; PDBTitle: nmr structure of the n-terminal coiled coil domain of the2 andes hantavirus nucleocapsid protein Phyre2 PDB 2tpt chain A domain 2 Region: 71 - 108 Aligned: 38 Modelled: 38 Confidence: 9.6% Identity: 21% Fold: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family: Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Phyre2 PDB 2cve chain A Region: 51 - 58 Aligned: 8 Modelled: 8 Confidence: 8.6% Identity: 75% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ttha1053; PDBTitle: crystal structure of a conserved hypothetical protein tt1547 from2 thermus thermophilus hb8 Phyre2 PDB 3svi chain A Region: 28 - 42 Aligned: 15 Modelled: 15 Confidence: 8.5% Identity: 27% PDB header:signaling protein Chain: A: PDB Molecule:type iii effector hopab2; PDBTitle: structure of the pto-binding domain of hoppmal generated by limited2 thermolysin digestion Phyre2 PDB 1vi7 chain A Region: 51 - 58 Aligned: 8 Modelled: 8 Confidence: 8.3% Identity: 50% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yigz; PDBTitle: crystal structure of an hypothetical protein Phyre2 1 c3dxrA_ 2 c3dxrB_ 3 d2bska1 4 c3cjhJ_ 5 c2bskD_ 6 c2k19A_ 7 c2iqcA_ 8 d2cvea1 9 d2bskb1 10 c2xglB_ 11 d1vi7a1 12 d2incc1 13 c3hgkE_ 14 c3ol4B_ 15 d1x4pa1 16 c2k48A_ 17 d2tpta2 18 c2cveA_ 19 c3sviA_ 20 c1vi7A_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3dxrA_ 33.2 26 PDB header:protein transport Chain: A: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 2 c3dxrB_ 32.1 33 PDB header:protein transport Chain: B: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the yeast inter-membrane space2 chaperone assembly tim9.10 3 d2bska1 28.1 32 Fold:Tim10-like Superfamily:Tim10-like Family:Tim10/DDP 4 c3cjhJ_ 28.1 32 PDB header:protein transport Chain: J: PDB Molecule:mitochondrial import inner membrane translocase subunit PDBTitle: tim8-tim13 complex 5 c2bskD_ 22.2 37 PDB header:protein transport Chain: D: PDB Molecule:mitochondrial import inner membrane translocase PDBTitle: crystal structure of the tim9 tim10 hexameric complex 6 c2k19A_ 21.9 39 PDB header:antimicrobial protein Chain: A: PDB Molecule:putative piscicolin 126 immunity protein; PDBTitle: nmr solution structure of pisi 7 c2iqcA_ 16.9 38 PDB header:protein binding Chain: A: PDB Molecule:fanconi anemia group f protein; PDBTitle: crystal structure of human fancf protein that functions in2 the assembly of a dna damage signaling complex 8 d2cvea1 14.0 75 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:YigZ N-terminal domain-like 9 d2bskb1 12.7 33 Fold:Tim10-like Superfamily:Tim10-like Family:Tim10/DDP 10 c2xglB_ 12.4 29 PDB header:antibiotic Chain: B: PDB Molecule:colicin-m immunity protein; PDBTitle: the x-ray structure of the escherichia coli colicin m immunity2 protein demonstrates the presence of a disulphide bridge, which is3 functionally essential 11 d1vi7a1 11.1 50 Fold:Ribosomal protein S5 domain 2-like Superfamily:Ribosomal protein S5 domain 2-like Family:YigZ N-terminal domain-like 12 d2incc1 11.1 53 Fold:beta-Grasp (ubiquitin-like) Superfamily:TmoB-like Family:TmoB-like 13 c3hgkE_ 11.0 33 PDB header:transferase Chain: E: PDB Molecule:effector protein hopab2; PDBTitle: crystal structure of effect protein avrptob complexed with2 kinase pto 14 c3ol4B_ 11.0 40 PDB header:unknown function Chain: B: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of a putative uncharacterized protein from2 mycobacterium smegmatis, an ortholog of rv0543c 15 d1x4pa1 10.6 53 Fold:Surp module (SWAP domain) Superfamily:Surp module (SWAP domain) Family:Surp module (SWAP domain) 16 c2k48A_ 10.6 36 PDB header:viral protein Chain: A: PDB Molecule:nucleoprotein; PDBTitle: nmr structure of the n-terminal coiled coil domain of the2 andes hantavirus nucleocapsid protein 17 d2tpta2 9.6 21 Fold:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Superfamily:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain Family:Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain 18 c2cveA_ 8.6 75 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein ttha1053; PDBTitle: crystal structure of a conserved hypothetical protein tt1547 from2 thermus thermophilus hb8 19 c3sviA_ 8.5 27 PDB header:signaling protein Chain: A: PDB Molecule:type iii effector hopab2; PDBTitle: structure of the pto-binding domain of hoppmal generated by limited2 thermolysin digestion 20 c1vi7A_ 8.3 50 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein yigz; PDBTitle: crystal structure of an hypothetical protein 21 c2kvcA_ not modelled 7.8 60 PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: solution structure of the mycobacterium tuberculosis protein rv0543c,2 a member of the duf3349 superfamily. seattle structural genomics3 center for infectious disease target mytud.17112.a 22 d1ci3m2 not modelled 7.7 39 Fold:Barrel-sandwich hybrid Superfamily:Rudiment single hybrid motif Family:Cytochrome f, small domain 23 c3p43A_ not modelled 7.5 36 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: structure and activities of archaeal members of the ligd 3'2 phosphoesterase dna repair enzyme superfamily 24 c2lkyA_ not modelled 7.4 50 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of msmeg_1053, the second duf3349 annotated protein2 in the genome of mycobacterium smegmatis, seattle structural genomics3 center for infectious disease target mysma.17112.b 25 d1zvsa1 not modelled 7.1 24 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C1 set domains (antibody constant domain-like) 26 c2xksA_ not modelled 7.0 20 PDB header:immune system Chain: A: PDB Molecule:beta-2-microglobulin; PDBTitle: prion-like conversion during amyloid formation at atomic2 resolution 27 c3kxeD_ not modelled 6.8 35 PDB header:protein binding Chain: D: PDB Molecule:antitoxin protein pard-1; PDBTitle: a conserved mode of protein recognition and binding in a2 pard-pare toxin-antitoxin complex 28 c1xvlC_ not modelled 6.8 30 PDB header:metal transport Chain: C: PDB Molecule:mn transporter; PDBTitle: the three-dimensional structure of mntc from synechocystis2 6803 29 d1ffkw_ not modelled 6.6 50 Fold:Rubredoxin-like Superfamily:Zn-binding ribosomal proteins Family:Ribosomal protein L37ae 30 d1wgna_ not modelled 6.4 67 Fold:RuvA C-terminal domain-like Superfamily:UBA-like Family:UBA domain 31 d1qo3a1 not modelled 6.1 29 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C1 set domains (antibody constant domain-like) 32 c1s1i0_ not modelled 6.1 38 PDB header:ribosome Chain: 0: PDB Molecule:60s ribosomal protein l32; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from2 yeast obtained by docking atomic models for rna and protein3 components into a 11.7 a cryo-em map. this file, 1s1i,4 contains 60s subunit. the 40s ribosomal subunit is in file5 1s1h. 33 c4a1cX_ not modelled 6.1 55 PDB header:ribosome Chain: X: PDB Molecule:60s ribosomal protein l32; PDBTitle: t.thermophila 60s ribosomal subunit in complex with2 initiation factor 6. this file contains 5s rrna,3 5.8s rrna and proteins of molecule 4. 34 d1ydpa1 not modelled 6.0 24 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C1 set domains (antibody constant domain-like) 35 c3ardB_ not modelled 5.9 13 PDB header:immune system Chain: B: PDB Molecule:beta-2-microglobulin; PDBTitle: ternary crystal structure of the mouse nkt tcr-cd1d-3'deoxy-alpha-2 galactosylceramide 36 c3areB_ not modelled 5.9 13 PDB header:immune system Chain: B: PDB Molecule:beta-2-microglobulin; PDBTitle: ternary crystal structure of the mouse nkt tcr-cd1d-4'deoxy-alpha-2 galactosylceramide 37 c2zkry_ not modelled 5.6 75 PDB header:ribosomal protein/rna Chain: Y: PDB Molecule:5s ribosomal rna; PDBTitle: structure of a mammalian ribosomal 60s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 38 d1a6tb2 not modelled 5.3 19 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C1 set domains (antibody constant domain-like) 39 d1sm3h2 not modelled 5.2 24 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C1 set domains (antibody constant domain-like) 40 d1de4a1 not modelled 5.2 17 Fold:Immunoglobulin-like beta-sandwich Superfamily:Immunoglobulin Family:C1 set domains (antibody constant domain-like) 41 c3cceY_ not modelled 5.2 50 PDB header:ribosome Chain: Y: PDB Molecule:50s ribosomal protein l32e; PDBTitle: structure of anisomycin resistant 50s ribosomal subunit: 23s rrna2 mutation u2535a 42 d1vqoy1 not modelled 5.2 50 Fold:Barstar-like Superfamily:Ribosomal protein L32e Family:Ribosomal protein L32e 43 c1dfwA_ not modelled 5.1 36 PDB header:immune system Chain: A: PDB Molecule:lung surfactant protein b; PDBTitle: conformational mapping of the n-terminal segment of2 surfactant protein b in lipid using 13c-enhanced fourier3 transform infrared spectroscopy (ftir)

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0