|   |
89 | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | |
|
. | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | |
Predicted Secondary structure |   |
 |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
| . | . |
|  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
| . |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
Query Sequence |   |
T | V | L | H | T | N | L | G | R | A | L | Q | A | E | A | A | V | E | A | V | A | Q | A | M | R | S | P | V | T | L | E | Y | D | L | D | D | A | G | R | G | H | R | D | R | A | L | A | Q | L | L | C | R | I | T | G | A | . |
. |
E | D | A | C | I | V | N | N | N | A | A | A | V | L | L | M | L | A | A | T | A | . |
Query Conservation |   |
  |   |   |   |
|   |
|
|   |   |   |   |   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |
|   |
|   | . | . |
|   |
|   |
|   |   |
|
|   |   |
|   |   |
|
|
|   |
|
|   | . |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
Template Conservation |   |
|   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |
|
| . | . | . | . | . | . | . | . |   |   |   |   |   |   |
|
|   |   |
|
|   |   |   |   |   |   |   |   |   |
|   |   |
|   |
|   |   |   |   |
|   |   |   |   |   |   |
|   |   |
Template Sequence |   |
I | R | I | N | F | N | E | N | P | L | G | X | S | P | K | A | Q | A | A | A | R | D | A | V | V | K | A | N | R | Y | A | . |
. |
. |
. |
. |
. |
. |
. |
K | N | E | I | L | X | L | G | N | K | L | A | A | H | H | Q | V | E | A | P | S | I | L | L | T | A | G | S | S | E | G | I | R | A | A | I | E | A | Y | A | S |
Template Known Secondary structure |   |
 |  |
| S | S |
|
|
| S | S |
|
|
|  |  |  |  |  |  |  |  |  |  | G | G | G | T | T | S |
|
| . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  | T | T | S |
| G | G | G |  |  |  |  | S |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
Template Predicted Secondary structure |   |
 |  |
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
| . | . | . | . | . | . | . | . |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|
|
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
59 | 60 | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | |
|
|
|
|
|
|
|
90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120 | . | . | . | . | . | . | . | . | . | 130 |
  |
  |   |
166 | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | |
|
|
|
. | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240 | . |
Predicted Secondary structure |   |
|
|
|  |  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |
|
|
|
|
| . | . | . | . |
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
. |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
S | G | K | E | V | V | V | S | R | G | E | L | V | E | I | G | G | A | F | R | I | P | D | V | M | R | Q | A | G | C | T | L | H | E | V | G | T | T | N | . |
. |
. |
. |
R | T | H | A | N | D | Y | R | Q | A | V | N | E | N | T | A | L | L | M | K | V | H | T | S | N | Y | S | I | Q | G | F | T | K | A | I | D | E |
Query Conservation |   |
  |   |   |
|
|
|
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |
|   |   |   |   | . | . | . | . |   |   |   |   |   |   |   |   |   |
|
|   |   |   |
|   |   |
|   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |
|
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
Template Conservation |   |
  |
|
|   |
|   |
|   |   |
|   |
|   |   |   | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|
|
|   |   |   |   |   |   | . |   |
|
Template Sequence |   |
L | E | A | Q | L | V | I | P | E | L | T | Y | G | D | G | . |
. |
. |
. |
. |
. |
E | H | F | A | K | I | A | G | X | K | V | T | K | V | K | X | L | D | N | W | A | F | D | I | E | G | L | K | A | A | V | A | A | Y | S | G | P | S | I | V | Y | L | V | N | P | N | N | P | T | G | T | I | T | P | A | D | . |
V | I |
Template Known Secondary structure |   |
T | T |
|  |  |  |  |  | S | S | S |
| T |  |  | . | . | . | . | . | . |  |  |  |  |  |  | T | T |
|  |  |  |  |  |
|
|
| T | T | S |
|
|
|  |  |  |  |  |  |  |  |  | T |
|
| S |
|  |  |  |  |  |  | S | S |
| T | T | T |
|
|
|
|
|  |  | . |  |  |
Template Predicted Secondary structure |   |
|
|
|  |  |  |  |
|
|
|
|
|  |  |  | . | . | . | . | . | . |  |  |  |  |  |  |  |
|
|
|  |  |  |
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|  |  | . |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
131 | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | |
|
|
|
|
|
. | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180 | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | |
. | . |
  |
  |   |
242 | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | |
|
. | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|  | . | . |  |  |  |  |  |  |
|  |  |  |  |  |  |  |  |  |
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
A | E | L | V | A | L | G | K | E | L | D | V | P | V | V | T | D | L | G | S | G | S | L | V | D | L | S | Q | Y | G | L | P | K | E | P | M | P | Q | E | L | I | A | A | G | V | S | L | V | S | F | S | G | D | K | L | L | G | G | P | Q | . |
. |
A | G | I | I | V | G | K | K | E | M | I | A | R | L | Q | S | H | P |
Query Conservation |   |
  |   |
|   |   |
|
|   |   |   |
|
|   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|
|
|
|   |   |
|   |   |
|   |   |
|
|   |   | . | . |   |
|   |
|   |
|   |   |   |   |
|   |   |   |   |   |   |   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
  |   |
|   |   |   |
|   |   |   |   |   |   |
|
| . |
|
|   |
|   |   |   |   |   |   |   |   |   | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|   |   |   |   |   |
|   |
|   |
|   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |
Template Sequence |   |
E | P | W | I | A | S | K | P | A | N | T | X | F | I | V | . |
D | E | A | Y | A | E | F | V | N | D | P | R | F | . |
. |
. |
R | S | I | S | P | X | I | T | Q | G | A | E | N | I | I | L | L | K | T | F | S | K | I | H | A | X | A | G | X | R | V | G | Y | A | V | A | H | P | T | V | I | A | L | X | G | R | Y | V |
Template Known Secondary structure |   |
 |  |  |  |  | T |
|
| T | T |  |  |  |  |  | . |  |
| T | T | G | G | G |
|
|
| T | T |
| . | . | . |
|
| S |  |  |  |  |  | T | T |
| S | S |  |  |  |  |  |  | S | S | S | T | T |
|
| G | G | G |
|
|  |  |  |  |
|
|  |  |  |  |  |  |  |  | T | T | T |
Template Predicted Secondary structure |   |
 |  |  |  |  |  |  |  |  |
|
|
|  |  |  | . |  |
|
|
|  |  |  |  |
|
|
|
|
| . | . | . |
|
|
|  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
204 | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | |
. | 220 | . | . | . | . | . | . | . | . | . | 230 | . | |
|
|
. | . | . | . | . | . | . | . | 240 | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . |
  |
  |   |
320 | . | . | . | . | . | . | . | . | . | 330 | . | . | . | . | . | . | . | . | . | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . | . | . | . | . | 390 | . | . | . | . | . | . | . | . | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|
|
|
|
|
|
|
|  |  |
|
|
|
|
|
|
|
|
|
|
|
|
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
L | K | R | A | L | R | A | D | K | M | T | L | A | A | L | E | A | T | L | R | L | Y | L | H | P | E | A | L | S | E | K | L | P | T | L | R | L | L | T | R | S | A | E | V | I | Q | I | Q | A | Q | R | L | Q | A | P | L | A | A | H | Y | G | A | E | F | A | V | Q | V | M | P | C | L | S | Q | I | G | S | G | S | L |
Query Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |
|
|   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |
|   |   |
|   |   |   |   |   |   |
|   |   |   |
|   |   |
|   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |
|
|   |
Alig confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
| . | . | . | . | . |
Template Conservation |   |
  |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |   |   |   |   |   | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |   |   |   |   |   |   |   |   |   |   |   |   |   |
|   |   |   |
|   |   | . | . | . | . | . |   |
|   |   |   |   |
|   |   |   |   |   | . | . | . | . | . |
Template Sequence |   |
A | G | E | K | I | N | F | S | G | V | D | A | A | L | A | S | X | N | D | S | A | F | I | . |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
. |
T | Y | S | K | K | S | N | D | V | S | R | Q | I | L | L | K | A | L | E | D | . |
. |
. |
. |
. |
L | K | L | P | Y | L | P | S | E | G | N | F | . |
. |
. |
. |
. |
Template Known Secondary structure |   |
T | S | S |
|
|
|  |  |  |  |  |  |  |  |  |  |  |  |
|  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . |  | T |
|
| B |
|
|
|
| S | S |  | . | . | . | . | . |
Template Predicted Secondary structure |   |
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|
|  |  |  |  | . | . | . | . | . | . | . | . | . | . | . | . | . | . | . |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | . | . | . | . | . |
|
|
|  |  |
|
|
|
|
|  |  | . | . | . | . | . |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300 | . | . | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
. | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | . | . | 320 | . | . | |
|
|
|
|
. | . | . | . | . | . | . | 330 | . | . | . | . | |
|
|
|
|
  |
  |   |
400 | . | . | . | . | . | . | . | . | . | 410 | . | . | . | . | . | . | . | . | . | 420 | . | . | . | . | . | . | . | . | . | 430 | . | . | . | . | . | . | . | . | . | |
|
440 | . | . | . | . | . | . | . | . | . | 450 | . | . | . | . | . | . | . | . | . | 460 | . |
Predicted Secondary structure |   |
|
|
|
|
|
|
|  |  |  |  |  |  |  |
|
|
|
|
|
|
|  |  |  |  |  |  |  |  |  |
|
|
|
|
|  |  |  |  |  | . | . |  |
|
|  |  |  |  |  |
|
|
|
|
|
|  |  |  |  |  |  |  |  |
Query SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . |
. |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Query Sequence |   |
P | V | D | R | L | P | S | A | A | L | T | F | T | P | H | D | G | R | G | S | H | L | E | S | L | A | A | R | W | R | E | L | P | V | P | V | I | G | R | I | . |
. |
Y | D | G | R | L | W | L | D | L | R | C | L | E | D | E | Q | R | F | L | E | M | L |
Query Conservation |   |
|   |   |   |
|   |   |   |   |
|   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|
|   |   |   |   |
|
|   |   |
|
| . | . |   |   |   |   |
|   |
|   |   |
|
|
|   |
|   |
|   |
|
|   |   |
|
Alig confidence |   |
. | . | . | . | . | . | . | . | . |
|
|
|
| . | . | . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| . | . |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Template Conservation |   |
. | . | . | . | . | . | . | . | . |   |   |   |   | . | . | . | . |   |   |   |   |   |   |   |
|   |   |   |
|   |   |   |
|
|   |
|   |   |   |   |   |   |   |   |   |   |
|
|
|
|   |   |   |   |
|
|   |   |   |
|
|   |
|
|
Template Sequence |   |
. |
. |
. |
. |
. |
. |
. |
. |
. |
V | F | H | Q | . |
. |
. |
. |
L | V | V | P | L | K | D | Y | Q | T | H | X | A | D | A | G | V | L | I | G | R | A | F | P | P | A | D | N | W | C | R | I | S | L | G | T | P | Q | E | X | Q | W | V | A | D | T | X |
Template Known Secondary structure |   |
. | . | . | . | . | . | . | . | . |  |  |  |  | . | . | . | . |
| S | S |
|  |  |  |  |  |  |  |  |  |  | T | T |  |  |
|
|
|
|
| T | T |
| T | T |  |  |  |  |  |
|
|
|  |  |  |  |  |  |  |  |  |  |  |
Template Predicted Secondary structure |   |
. | . | . | . | . | . | . | . | . |  |  |  |  | . | . | . | . |
|
|
|
|  |  |  |  |  |  |  |  |  |  |
|
|  |  |  |
|
|
|
|
|
|
|
|
|  |  |  |  |  |  |
|
|  |  |  |  |  |  |  |  |  |  |  |
Template SS confidence |   |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
  |   |
|
|
|
|
|
|
|
|
|
335 | . | . | . | |
|
|
|
. | 340 | . | . | . | . | . | . | . | . | . | 350 | . | . | . | . | . | . | . | . | . | 360 | . | . | . | . | . | . | . | . | . | 370 | . | . | . | . | . | . | . | . | . | 380 | . | . | . | . | . |
  |