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Job DescriptionP06864
Confidence100.00%DateThu Jan 5 10:59:27 GMT 2012
Rank10Aligned Residues525
% Identity24%Templatec3lpgA_
PDB info PDB header:hydrolase/hydrolase inhibitorChain: A: PDB Molecule:beta-glucuronidase; PDBTitle: structure of e. coli beta-glucuronidase bound with a novel, potent2 inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,3 2-dihydroquinolin-3-yl)methyl)urea
Resolution2.42 Å

  Insertion relative to template
  Deletion relative to template
  Catalytic residue from the CSA
 
Detailed help on interpreting your alignment


   36...40.........50.........60.........70.........80.........90.........100.........110.....
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Query Sequence  ETSSLFLPLSGQWNFHFFDHPLQVPEAFTSELMADWGHITVPAMWQMEGHGKLQYTDEGFPFPIDVPFVPSDNPTGAYQR
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Template Sequence  TPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADIR. . . . . . . . . . . . . . . NYAGNVWYQR
Template Known Secondary structure  SS





SSS

TTTTTGGGS

TT
SSS
SSGGGT
...............T

S
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   7..10.........20.........30.........40.........50.........60. ........70.
 
   116...120.........130.........140.........150.........160.........170 .........180.......
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Query Sequence  IFTLSDGWQGKQTLIKFDGVETYFEVYVNGQYVGFSKGSRLTAEFDISAMVKTGD. NLLCVRVMQWADSTYVE. . . . . . .
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Template Sequence  EVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVXEHQGGYTPFEADVTPYVIAGKSVRITVCVNNELNWQTIPPGXVITD
Template Known Secondary structure 

GGGTTSS

SSSS


SSS

GGG

TTS



TTSSS

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   72.......80.........90.........100.........110.........120.........130.........140.........150.
 
   188.190.........200.........210.........220.........230.........240.........250........
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Query Sequence  . . . . . . . . . DQDMWWSAGIFRDVYLVGKHLTHINDFTVRTDFDEAYCDATLSCEVVLENLAASPVVTTLEYTLFDGERVV
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Template Sequence  ENGKKKQSYFHDFFNYAGIHRSVXLYTTPNTWVDDITVVTHVAQDCNHASVDWQVVANG. . . . . . . . DVSVELRDADQQV
Template Known Secondary structure  TT

SSSB



S

S

SS

SSSS


SS........
TT

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   152.......160.........170.........180.........190.........200.........210 .........220...
 
   259260.........270.........280.........290.........300.........310.........320.........330........
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Query Sequence  HSSAIDHLAIEKLTSASFAFTVEQPQQWSAESPYLYHLVMTLKDANGNVLEVVPQRVGFRDIKVRDGLFWINNRYVMLHG
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Template Sequence  VATGQ. . . . . . . . . GTSGTLQVVNPHLWQPGEGYLYELCVTA. . KSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTG
Template Known Secondary structure  .........SSS








TTT


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SS




TTTT

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   224.... .230.........240.........250...... ...260.........270.........280.........290..
 
   339340.........350.........360.........370.........380.........390.........400.........
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Query Sequence  VNRHDNDHRKGRAVGMDRVEKDLQLMKQHNINSVRTAHYPNDPRFYELCDIYGLFVMAETDVESHGFANVG. . . . . . . . .
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Template Sequence  FGRHEDADLRGKGFDNVLXVHDHALXDWIGANSYRTSHYPYAEEXLDWADEHGIVVIDETAAVGFNLSLGIGFEAGNKPK
Template Known Secondary structure 

S
BTTTBT


T


TTS


T

S
B


S



SSS




S
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   293......300.........310.........320.........330.........340.........350.........360.........370..
 
   410.........420.........430.........440.........450..... ....460.........470.... .
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Query Sequence  . DISRITDDPQWEKVYVERIVRHIHAQKNHPSIIIWSLGNESGYGCN. . . . . IRAMYHAAKALDDTRLVHY. . . . . . . . E
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Template Sequence  ELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVXWSIANEPDTRPQGAREYFAPLAEATRKLDPTRPITCVNVXFCDAH
Template Known Secondary structure 
SSBTTTB
TT
TT




ST
SSS
B
TTS
TT
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   373......380.........390.........400.........410.........420.........430.........440.........450..
 
   476...480......... 490.. .......500.........510.... .....520... ...
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Query Sequence  EDRDAEVVDIISTM. YTR. . . . . . . . . . . . . . VPLMNEFGEYPHPKPRIICEYA. . . . . . . HAMGNGPGG. . . . . . . LTE
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Template Sequence  TDTISDLFDVLCLNRYYGWYVQSGDLETAEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSXYTDXWSEEYQCAWLDX
Template Known Secondary structure  T
SSGGGSSS

BTTTBSTT









TT


TT

TTS
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   453......460.........470.........480.........490.........500.........510.........520.........530..
 
   527..530.........540.........550.........560.........570.........580.........590.........600......
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Query Sequence  YQNVFYKHDCIQGHYVWEWCDHGIQAQDDHGNVWYKFGGDYGDYPNNYNFCLDGLIYSDQTPGPGLKEYKQVIAPVKIHA
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Template Sequence  YHRVFDRVSAVVGEQVWNFADFATSQGIL. . . . . . . . . . . . . . . . . RVGGNKKGIFTRDRKPKSAAFLLQKRWTGXNF. G
Template Known Secondary structure  TT
TTS
B
B

BTT.................BSSSB


TT

B
TS
T.T
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   533......540.........550.........560. ........570.........580.........590... .
 
   607..610..
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Query Sequence  RDLTRG
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Template Conservation    
   
Template Sequence  EKPQQG
Template Known Secondary structure 



S
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   595....600
 
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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
 
© Structural Bioinformatics Group, Imperial College, London
Lawrence Kelley, Benjamin Jefferys 
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