Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	Y	D	S	V	Y	S	E	K	R	P	P	G	T	L	R	T	A	W	R	K	F	Y	S	D	A	S	A	M	V	G	L	Y	G	C	A	G	L	A	V	L	C	I	F	G	G	W	F	A	P	Y	G	I	D	Q	Q	F	L	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		Y	Q	L	L	P	P	S	W	S	R	Y	G	E	V	S	F	F	L	G	T	D	D	L	G	R	D	V	L	S	R	L	L	S	G	A	A	P	T	V	G	G	A	F	V	V	T	L	A	A	T	I	C	G	L	V	L	G	T	F	A
Secondary structure
SS confidence
Disorder						?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	A	T	H	G	L	R	S	A	V	L	N	H	I	L	D	T	L	L	A	I	P	S	L	L	L	A	I	I	V	V	A	F	A	G	P	S	L	S	H	A	M	F	A	V	W	L	A	L	L	P	R	M	V	R	S	I	Y	S	M
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		V	H	D	E	L	E	K	E	Y	V	I	A	A	R	L	D	G	A	S	T	L	N	I	L	W	F	A	V	M	P	N	I	T	A	G	L	V	T	E	I	T	R	A	L	S	M	A	I	L	D	I	A	A	L	G	F	L	D	L	G
Secondary structure
SS confidence
Disorder						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.
Sequence		A	Q	L	P	S	P	E	W	G	A	M	L	G	D	A	L	E	L	I	Y	V	A	P	W	T	V	M	L	P	G	A	A	I	M	I	S	V	L	L	V	N	L	L	G	D	G	V	R	R	A	I	I	A	G	V	E
Secondary structure
SS confidence
Disorder																																																						?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2onk chain C Region: 22 - 287 Aligned: 235 Modelled: 242 Confidence: 99.9% Identity: 16% PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda Phyre2 PDB 2onk chain C domain 1 Region: 22 - 287 Aligned: 235 Modelled: 242 Confidence: 99.9% Identity: 16% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3dhw chain A domain 1 Region: 89 - 285 Aligned: 189 Modelled: 197 Confidence: 99.9% Identity: 21% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 2r6g chain F domain 2 Region: 71 - 282 Aligned: 208 Modelled: 212 Confidence: 99.9% Identity: 15% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain C domain 1 Region: 89 - 283 Aligned: 188 Modelled: 194 Confidence: 99.9% Identity: 18% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 3d31 chain D Region: 89 - 283 Aligned: 188 Modelled: 194 Confidence: 99.9% Identity: 18% PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans Phyre2 PDB 3fh6 chain F Region: 16 - 296 Aligned: 275 Modelled: 281 Confidence: 99.9% Identity: 15% PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli Phyre2 PDB 2r6g chain F Region: 66 - 283 Aligned: 213 Modelled: 218 Confidence: 99.9% Identity: 14% PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter Phyre2 PDB 2r6g chain G domain 1 Region: 24 - 285 Aligned: 259 Modelled: 262 Confidence: 99.8% Identity: 12% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 1p7b chain B Region: 4 - 129 Aligned: 119 Modelled: 126 Confidence: 73.3% Identity: 8% PDB header:metal transport Chain: B: PDB Molecule:integral membrane channel and cytosolic domains; PDBTitle: crystal structure of an inward rectifier potassium channel Phyre2 PDB 1p7b chain A domain 2 Region: 4 - 125 Aligned: 115 Modelled: 122 Confidence: 47.0% Identity: 8% Fold: Voltage-gated potassium channels Superfamily: Voltage-gated potassium channels Family: Voltage-gated potassium channels Phyre2 PDB 2jwa chain A Region: 96 - 129 Aligned: 34 Modelled: 34 Confidence: 24.8% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 PDB 2voy chain B Region: 7 - 41 Aligned: 35 Modelled: 35 Confidence: 9.2% Identity: 9% PDB header:hydrolase Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus Phyre2 PDB 2lhu chain A Region: 177 - 206 Aligned: 30 Modelled: 30 Confidence: 7.6% Identity: 17% PDB header:structural protein Chain: A: PDB Molecule:mybpc3 protein; PDBTitle: structural insight into the unique cardiac myosin binding protein-c2 motif: a partially folded domain Phyre2 PDB 1umq chain A Region: 175 - 206 Aligned: 32 Modelled: 32 Confidence: 7.2% Identity: 6% PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity Phyre2 PDB 1umq chain A Region: 175 - 206 Aligned: 32 Modelled: 32 Confidence: 7.2% Identity: 6% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1ntc chain A Region: 175 - 207 Aligned: 33 Modelled: 33 Confidence: 6.3% Identity: 18% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1fip chain A Region: 175 - 207 Aligned: 33 Modelled: 33 Confidence: 5.7% Identity: 15% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 PDB 1eto chain B Region: 175 - 207 Aligned: 33 Modelled: 33 Confidence: 5.7% Identity: 15% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Homeodomain-like Family: FIS-like Phyre2 1 c2onkC_ 2 d2onkc1 3 d3dhwa1 4 d2r6gf2 5 d3d31c1 6 c3d31D_ 7 c3fh6F_ 8 c2r6gF_ 9 d2r6gg1 10 c1p7bB_ 11 d1p7ba2 12 c2jwaA_ 13 c2voyB_ 14 c2lhuA_ 15 c1umqA_ 16 d1umqa_ 17 d1ntca_ 18 d1fipa_ 19 d1etob_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2onkC_ 99.9 16 PDB header:membrane protein Chain: C: PDB Molecule:molybdate/tungstate abc transporter, permease PDBTitle: abc transporter modbc in complex with its binding protein2 moda 2 d2onkc1 99.9 16 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 3 d3dhwa1 99.9 21 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 4 d2r6gf2 99.9 15 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 5 d3d31c1 99.9 18 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 6 c3d31D_ 99.9 18 PDB header:transport protein Chain: D: PDB Molecule:sulfate/molybdate abc transporter, permease PDBTitle: modbc from methanosarcina acetivorans 7 c3fh6F_ 99.9 15 PDB header:transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: crystal structure of the resting state maltose transporter from e.2 coli 8 c2r6gF_ 99.9 14 PDB header:hydrolase/transport protein Chain: F: PDB Molecule:maltose transport system permease protein malf; PDBTitle: the crystal structure of the e. coli maltose transporter 9 d2r6gg1 99.8 12 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 10 c1p7bB_ 73.3 8 PDB header:metal transport Chain: B: PDB Molecule:integral membrane channel and cytosolic domains; PDBTitle: crystal structure of an inward rectifier potassium channel 11 d1p7ba2 47.0 8 Fold:Voltage-gated potassium channels Superfamily:Voltage-gated potassium channels Family:Voltage-gated potassium channels 12 c2jwaA_ 24.8 18 PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure 13 c2voyB_ 9.2 9 PDB header:hydrolase Chain: B: PDB Molecule:sarcoplasmic/endoplasmic reticulum calcium PDBTitle: cryoem model of copa, the copper transporting atpase from2 archaeoglobus fulgidus 14 c2lhuA_ 7.6 17 PDB header:structural protein Chain: A: PDB Molecule:mybpc3 protein; PDBTitle: structural insight into the unique cardiac myosin binding protein-c2 motif: a partially folded domain 15 c1umqA_ 7.2 6 PDB header:dna-binding protein Chain: A: PDB Molecule:photosynthetic apparatus regulatory protein; PDBTitle: solution structure and dna binding of the effector domain2 from the global regulator prra(rega) from r. sphaeroides:3 insights into dna binding specificity 16 d1umqa_ 7.2 6 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 17 d1ntca_ 6.3 18 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 18 d1fipa_ 5.7 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like 19 d1etob_ 5.7 15 Fold:DNA/RNA-binding 3-helical bundle Superfamily:Homeodomain-like Family:FIS-like

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0