Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	F	R	M	S	E	Q	P	R	T	I	K	I	Y	N	L	L	A	G	T	N	E	F	I	G	E	G	D	A	Y	I	P	P	H	T	G	L	P	A	N	S	T	D	I	A	P	P	D	I	P	A	G	F	V	A	V	F	N	S
Secondary structure
SS confidence
Disorder		?	?			?	?	?																				?	?		?	?	?	?	?															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	E	S	S	W	H	L	V	E	D	H	R	G	K	T	V	Y	D	V	A	S	G	D	A	L	F	I	S	E	L	G	P	L	P	E	N	V	T	W	L	S	P	E	G	E	F	Q	K	W	N	G	T	A	W	V	K	D	T	E	A
Secondary structure
SS confidence
Disorder																																												?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	K	L	F	R	I	R	E	A	E	E	T	K	N	N	L	M	Q	V	A	S	E	H	I	A	P	L	Q	D	A	A	D	L	E	I	A	T	E	E	E	I	S	L	L	E	A	W	K	K	Y	R	V	L	L	N	R	V	D	T	S
Secondary structure
SS confidence
Disorder																																		?	?																						?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.
Sequence		T	A	Q	D	I	E	W	P	A	L	P
Secondary structure
SS confidence
Disorder		?				?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 2kz6 chain A Region: 119 - 191 Aligned: 64 Modelled: 73 Confidence: 97.5% Identity: 22% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2 Phyre2 PDB 1jof chain A Region: 3 - 96 Aligned: 89 Modelled: 90 Confidence: 46.0% Identity: 17% Fold: 7-bladed beta-propeller Superfamily: 3-carboxy-cis,cis-mucoante lactonizing enzyme Family: 3-carboxy-cis,cis-mucoante lactonizing enzyme Phyre2 PDB 1gk6 chain B Region: 120 - 175 Aligned: 50 Modelled: 56 Confidence: 39.6% Identity: 20% PDB header:vimentin Chain: B: PDB Molecule:vimentin; PDBTitle: human vimentin coil 2b fragment linked to gcn4 leucine2 zipper (z2b) Phyre2 PDB 2xv5 chain A Region: 121 - 175 Aligned: 49 Modelled: 55 Confidence: 37.5% Identity: 24% PDB header:structural protein Chain: A: PDB Molecule:lamin-a/c; PDBTitle: human lamin a coil 2b fragment Phyre2 PDB 1rfo chain C Region: 47 - 68 Aligned: 20 Modelled: 20 Confidence: 34.5% Identity: 25% PDB header:viral protein Chain: C: PDB Molecule:whisker antigen control protein; PDBTitle: trimeric foldon of the t4 phagehead fibritin Phyre2 PDB 2kt9 chain A Region: 102 - 162 Aligned: 61 Modelled: 61 Confidence: 33.7% Identity: 20% PDB header:ribosomal protein Chain: A: PDB Molecule:probable 30s ribosomal protein psrp-3; PDBTitle: solution nmr structure of probable 30s ribosomal protein2 psrp-3 (ycf65-like protein) from synechocystis sp. (strain3 pcc 6803), northeast structural genomics consortium target4 target sgr46 Phyre2 PDB 3o0r chain C Region: 156 - 184 Aligned: 26 Modelled: 26 Confidence: 32.6% Identity: 15% PDB header:immune system/oxidoreductase Chain: C: PDB Molecule:nitric oxide reductase subunit c; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment Phyre2 PDB 1x8y chain A Region: 120 - 175 Aligned: 50 Modelled: 56 Confidence: 27.0% Identity: 24% PDB header:structural protein Chain: A: PDB Molecule:lamin a/c; PDBTitle: human lamin coil 2b Phyre2 PDB 1v1h chain B Region: 47 - 68 Aligned: 20 Modelled: 22 Confidence: 25.7% Identity: 25% PDB header:adenovirus Chain: B: PDB Molecule:fibritin, fiber protein; PDBTitle: adenovirus fibre shaft sequence n-terminally fused to the2 bacteriophage t4 fibritin foldon trimerisation motif with3 a short linker Phyre2 PDB 2jxw chain A Region: 13 - 85 Aligned: 53 Modelled: 55 Confidence: 25.2% Identity: 21% PDB header:formin binding protein Chain: A: PDB Molecule:ww domain-binding protein 4; PDBTitle: solution structure of the tandem ww domains of fbp21 Phyre2 PDB 1k6n chain H Region: 2 - 90 Aligned: 89 Modelled: 89 Confidence: 24.3% Identity: 13% PDB header:photosynthesis Chain: H: PDB Molecule:photosynthetic reaction center h subunit; PDBTitle: e(l212)a,d(l213)a double mutant structure of photosynthetic reaction2 center from rhodobacter sphaeroides Phyre2 PDB 1gk4 chain A Region: 120 - 175 Aligned: 50 Modelled: 56 Confidence: 23.7% Identity: 26% PDB header:vimentin Chain: A: PDB Molecule:vimentin; PDBTitle: human vimentin coil 2b fragment (cys2) Phyre2 PDB 1ox3 chain A Region: 47 - 68 Aligned: 20 Modelled: 22 Confidence: 23.4% Identity: 25% PDB header:chaperone Chain: A: PDB Molecule:fibritin; PDBTitle: crystal structure of mini-fibritin Phyre2 PDB 3mov chain B Region: 120 - 175 Aligned: 50 Modelled: 56 Confidence: 22.3% Identity: 22% PDB header:structural protein Chain: B: PDB Molecule:lamin-b1; PDBTitle: crystal structure of human lamin-b1 coil 2 segment Phyre2 PDB 1rzh chain H domain 1 Region: 2 - 90 Aligned: 89 Modelled: 89 Confidence: 21.9% Identity: 13% Fold: PRC-barrel domain Superfamily: PRC-barrel domain Family: Photosynthetic reaction centre, H-chain, cytoplasmic domain Phyre2 PDB 1avy chain A Region: 47 - 68 Aligned: 20 Modelled: 20 Confidence: 21.2% Identity: 25% PDB header:coiled coil Chain: A: PDB Molecule:fibritin; PDBTitle: fibritin deletion mutant m (bacteriophage t4) Phyre2 PDB 2ov2 chain O Region: 17 - 26 Aligned: 10 Modelled: 10 Confidence: 15.8% Identity: 20% PDB header:protein binding/transferase Chain: O: PDB Molecule:serine/threonine-protein kinase pak 4; PDBTitle: the crystal structure of the human rac3 in complex with the crib2 domain of human p21-activated kinase 4 (pak4) Phyre2 PDB 2odb chain B Region: 17 - 26 Aligned: 10 Modelled: 10 Confidence: 14.1% Identity: 20% PDB header:protein binding Chain: B: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: the crystal structure of human cdc42 in complex with the crib domain2 of human p21-activated kinase 6 (pak6) Phyre2 PDB 2rm0 chain W domain 1 Region: 62 - 97 Aligned: 31 Modelled: 36 Confidence: 13.8% Identity: 26% Fold: WW domain-like Superfamily: WW domain Family: WW domain Phyre2 PDB 2dk1 chain A domain 1 Region: 63 - 97 Aligned: 30 Modelled: 35 Confidence: 12.5% Identity: 30% Fold: WW domain-like Superfamily: WW domain Family: WW domain Phyre2 1 c2kz6A_ 2 d1jofa_ 3 c1gk6B_ 4 c2xv5A_ 5 c1rfoC_ 6 c2kt9A_ 7 c3o0rC_ 8 c1x8yA_ 9 c1v1hB_ 10 c2jxwA_ 11 c1k6nH_ 12 c1gk4A_ 13 c1ox3A_ 14 c3movB_ 15 d1rzhh1 16 c1avyA_ 17 c2ov2O_ 18 c2odbB_ 19 d2rm0w1 20 d2dk1a1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c2kz6A_ 97.5 22 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of protein cv0426 from chromobacterium violaceum,2 northeast structural genomics consortium (nesg) target cvt2 2 d1jofa_ 46.0 17 Fold:7-bladed beta-propeller Superfamily:3-carboxy-cis,cis-mucoante lactonizing enzyme Family:3-carboxy-cis,cis-mucoante lactonizing enzyme 3 c1gk6B_ 39.6 20 PDB header:vimentin Chain: B: PDB Molecule:vimentin; PDBTitle: human vimentin coil 2b fragment linked to gcn4 leucine2 zipper (z2b) 4 c2xv5A_ 37.5 24 PDB header:structural protein Chain: A: PDB Molecule:lamin-a/c; PDBTitle: human lamin a coil 2b fragment 5 c1rfoC_ 34.5 25 PDB header:viral protein Chain: C: PDB Molecule:whisker antigen control protein; PDBTitle: trimeric foldon of the t4 phagehead fibritin 6 c2kt9A_ 33.7 20 PDB header:ribosomal protein Chain: A: PDB Molecule:probable 30s ribosomal protein psrp-3; PDBTitle: solution nmr structure of probable 30s ribosomal protein2 psrp-3 (ycf65-like protein) from synechocystis sp. (strain3 pcc 6803), northeast structural genomics consortium target4 target sgr46 7 c3o0rC_ 32.6 15 PDB header:immune system/oxidoreductase Chain: C: PDB Molecule:nitric oxide reductase subunit c; PDBTitle: crystal structure of nitric oxide reductase from pseudomonas2 aeruginosa in complex with antibody fragment 8 c1x8yA_ 27.0 24 PDB header:structural protein Chain: A: PDB Molecule:lamin a/c; PDBTitle: human lamin coil 2b 9 c1v1hB_ 25.7 25 PDB header:adenovirus Chain: B: PDB Molecule:fibritin, fiber protein; PDBTitle: adenovirus fibre shaft sequence n-terminally fused to the2 bacteriophage t4 fibritin foldon trimerisation motif with3 a short linker 10 c2jxwA_ 25.2 21 PDB header:formin binding protein Chain: A: PDB Molecule:ww domain-binding protein 4; PDBTitle: solution structure of the tandem ww domains of fbp21 11 c1k6nH_ 24.3 13 PDB header:photosynthesis Chain: H: PDB Molecule:photosynthetic reaction center h subunit; PDBTitle: e(l212)a,d(l213)a double mutant structure of photosynthetic reaction2 center from rhodobacter sphaeroides 12 c1gk4A_ 23.7 26 PDB header:vimentin Chain: A: PDB Molecule:vimentin; PDBTitle: human vimentin coil 2b fragment (cys2) 13 c1ox3A_ 23.4 25 PDB header:chaperone Chain: A: PDB Molecule:fibritin; PDBTitle: crystal structure of mini-fibritin 14 c3movB_ 22.3 22 PDB header:structural protein Chain: B: PDB Molecule:lamin-b1; PDBTitle: crystal structure of human lamin-b1 coil 2 segment 15 d1rzhh1 21.9 13 Fold:PRC-barrel domain Superfamily:PRC-barrel domain Family:Photosynthetic reaction centre, H-chain, cytoplasmic domain 16 c1avyA_ 21.2 25 PDB header:coiled coil Chain: A: PDB Molecule:fibritin; PDBTitle: fibritin deletion mutant m (bacteriophage t4) 17 c2ov2O_ 15.8 20 PDB header:protein binding/transferase Chain: O: PDB Molecule:serine/threonine-protein kinase pak 4; PDBTitle: the crystal structure of the human rac3 in complex with the crib2 domain of human p21-activated kinase 4 (pak4) 18 c2odbB_ 14.1 20 PDB header:protein binding Chain: B: PDB Molecule:serine/threonine-protein kinase pak 6; PDBTitle: the crystal structure of human cdc42 in complex with the crib domain2 of human p21-activated kinase 6 (pak6) 19 d2rm0w1 13.8 26 Fold:WW domain-like Superfamily:WW domain Family:WW domain 20 d2dk1a1 12.5 30 Fold:WW domain-like Superfamily:WW domain Family:WW domain 21 c2diiA_ not modelled 12.3 23 PDB header:transcription Chain: A: PDB Molecule:tfiih basal transcription factor complex p62 PDBTitle: solution structure of the bsd domain of human tfiih basal2 transcription factor complex p62 subunit 22 d2diia1 not modelled 12.2 23 Fold:BSD domain-like Superfamily:BSD domain-like Family:BSD domain 23 c2v43A_ not modelled 12.1 20 PDB header:regulator Chain: A: PDB Molecule:sigma-e factor regulatory protein rseb; PDBTitle: crystal structure of rseb: a sensor for periplasmic stress2 response in e. coli 24 d1ln1a_ not modelled 11.3 17 Fold:TBP-like Superfamily:Bet v1-like Family:STAR domain 25 c2dk7A_ not modelled 10.5 13 PDB header:transcription Chain: A: PDB Molecule:transcription elongation regulator 1; PDBTitle: solution structure of ww domain in transcription elongation2 regulator 1 26 c2ghsA_ not modelled 10.5 14 PDB header:calcium-binding protein Chain: A: PDB Molecule:agr_c_1268p; PDBTitle: crystal structure of a calcium-binding protein, regucalcin2 (agr_c_1268) from agrobacterium tumefaciens str. c58 at 1.55 a3 resolution 27 d2ghsa1 not modelled 10.5 14 Fold:6-bladed beta-propeller Superfamily:Calcium-dependent phosphotriesterase Family:SGL-like 28 d2oa5a1 not modelled 10.3 23 Fold:BLRF2-like Superfamily:BLRF2-like Family:BLRF2-like 29 d1x4ta1 not modelled 9.3 22 Fold:Long alpha-hairpin Superfamily:ISY1 domain-like Family:ISY1 N-terminal domain-like 30 c1e0aB_ not modelled 8.5 50 PDB header:signalling protein Chain: B: PDB Molecule:serine/threonine-protein kinase pak-alpha; PDBTitle: cdc42 complexed with the gtpase binding domain of p212 activated kinase 31 c1w18A_ not modelled 8.4 19 PDB header:transferase Chain: A: PDB Molecule:levansucrase; PDBTitle: crystal structure of levansucrase from gluconacetobacter2 diazotrophicus 32 d1o6wa1 not modelled 8.3 26 Fold:WW domain-like Superfamily:WW domain Family:WW domain 33 d1ll7a2 not modelled 7.9 17 Fold:FKBP-like Superfamily:Chitinase insertion domain Family:Chitinase insertion domain 34 c1zr7A_ not modelled 7.3 26 PDB header:signaling protein Chain: A: PDB Molecule:huntingtin-interacting protein hypa/fbp11; PDBTitle: solution structure of the first ww domain of fbp11 35 c2c7hA_ not modelled 7.2 29 PDB header:ubiquitin-like protein Chain: A: PDB Molecule:retinoblastoma-binding protein 6, isoform 3; PDBTitle: solution nmr structure of the dwnn domain from human rbbp6 36 d1w9pa2 not modelled 6.8 25 Fold:FKBP-like Superfamily:Chitinase insertion domain Family:Chitinase insertion domain 37 c3nmbA_ not modelled 6.4 18 PDB header:hydrolase Chain: A: PDB Molecule:putative sugar hydrolase; PDBTitle: crystal structure of a putative sugar hydrolase (bacova_03189) from2 bacteroides ovatus at 2.40 a resolution 38 c1f3mB_ not modelled 6.4 50 PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase pak-alpha; PDBTitle: crystal structure of human serine/threonine kinase pak1 39 d1pcna1 not modelled 6.3 33 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Colipase-like Family:Colipase-like 40 c2ysiA_ not modelled 6.3 23 PDB header:protein binding Chain: A: PDB Molecule:transcription elongation regulator 1; PDBTitle: solution structure of the first ww domain from the mouse2 transcription elongation regulator 1, transcription factor3 ca150 41 c2jz8A_ not modelled 6.2 9 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein bh09830; PDBTitle: solution nmr structure of bh09830 from bartonella henselae2 modeled with one zn+2 bound. northeast structural genomics3 consortium target bnr55 42 c2dk1A_ not modelled 6.2 26 PDB header:gene regulation Chain: A: PDB Molecule:ww domain-binding protein 4; PDBTitle: solution structure of ww domain in ww domain binding2 protein 4 (wbp-4) 43 c3ok8A_ not modelled 5.9 6 PDB header:protein binding Chain: A: PDB Molecule:brain-specific angiogenesis inhibitor 1-associated protein PDBTitle: i-bar of pinkbar 44 d1wi9a_ not modelled 5.6 53 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:PCI domain (PINT motif) 45 d2paja1 not modelled 5.6 15 Fold:Composite domain of metallo-dependent hydrolases Superfamily:Composite domain of metallo-dependent hydrolases Family:SAH/MTA deaminase-like 46 d1ocya_ not modelled 5.5 14 Fold:Receptor-binding domain of short tail fibre protein gp12 Superfamily:Receptor-binding domain of short tail fibre protein gp12 Family:Receptor-binding domain of short tail fibre protein gp12 47 c1aa0A_ not modelled 5.4 25 PDB header:attachment protein Chain: A: PDB Molecule:fibritin; PDBTitle: fibritin deletion mutant e (bacteriophage t4) 48 c2h47F_ not modelled 5.2 17 PDB header:oxidoreductase/electron transport Chain: F: PDB Molecule:aromatic amine dehydrogenase; PDBTitle: crystal structure of an electron transfer complex between2 aromatic amine dephydrogenase and azurin from alcaligenes3 faecalis (form 1) 49 d1j8ra_ not modelled 5.1 31 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Bacterial adhesins Family:PapG adhesin receptor-binding domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0