Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	Q	W	Y	L	S	V	L	K	N	Y	V	G	F	S	G	R	A	R	R	K	E	Y	W	M	F	T	L	I	N	A	I	V	G	A	I	I	N	V	I	Q	L	I	L	G	L	E	L	P	Y	L	S	M	L	Y	L	L	A	T	F
Secondary structure
SS confidence
Disorder		?																																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.
Sequence		L	P	V	L	A	L	A	I	R	R	L	H	D	T	D	R	S	G	A	W	A	L	L	F	F	V	P	F	I	G	W	L	V	L	L	V	F	F	C	T	E	G	T	S	G	S	N	R	Y	G	N	D	P	K	F	G	S	N
Secondary structure
SS confidence
Disorder																																														?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 4a1o chain B Region: 108 - 117 Aligned: 10 Modelled: 10 Confidence: 20.7% Identity: 40% PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. Phyre2 PDB 1zcz chain A Region: 100 - 117 Aligned: 18 Modelled: 18 Confidence: 18.9% Identity: 22% PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution Phyre2 PDB 1thz chain A Region: 108 - 117 Aligned: 10 Modelled: 10 Confidence: 18.5% Identity: 40% PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening Phyre2 PDB 2dyo chain B Region: 66 - 75 Aligned: 10 Modelled: 10 Confidence: 11.0% Identity: 60% PDB header:protein turnover/protein turnover Chain: B: PDB Molecule:autophagy protein 16; PDBTitle: the crystal structure of saccharomyces cerevisiae atg5-2 atg16(1-57) complex Phyre2 PDB 3rf1 chain B Region: 103 - 115 Aligned: 13 Modelled: 13 Confidence: 9.1% Identity: 31% PDB header:ligase Chain: B: PDB Molecule:glycyl-trna synthetase alpha subunit; PDBTitle: the crystal structure of glycyl-trna synthetase subunit alpha from2 campylobacter jejuni subsp. jejuni nctc 11168 Phyre2 PDB 1lir chain A Region: 67 - 76 Aligned: 10 Modelled: 10 Confidence: 8.1% Identity: 50% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Scorpion toxin-like Family: Short-chain scorpion toxins Phyre2 PDB 1bzg chain A Region: 71 - 77 Aligned: 7 Modelled: 7 Confidence: 8.0% Identity: 57% PDB header:hormone Chain: A: PDB Molecule:parathyroid hormone-related protein; PDBTitle: the solution structure of human parathyroid hormone-related2 protein (1-34) in near-physiological solution, nmr, 303 structures Phyre2 PDB 2axt chain I domain 1 Region: 82 - 107 Aligned: 26 Modelled: 26 Confidence: 7.9% Identity: 19% Fold: Single transmembrane helix Superfamily: Photosystem II reaction center protein I, PsbI Family: PsbI-like Phyre2 PDB 2l2t chain A Region: 47 - 70 Aligned: 24 Modelled: 24 Confidence: 7.5% Identity: 21% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain Phyre2 PDB 1gng chain X Region: 67 - 72 Aligned: 6 Modelled: 6 Confidence: 7.0% Identity: 83% PDB header:transferase Chain: X: PDB Molecule:frattide; PDBTitle: glycogen synthase kinase-3 beta (gsk3) complex with frattide2 peptide Phyre2 PDB 3skd chain A Region: 71 - 76 Aligned: 6 Modelled: 6 Confidence: 6.5% Identity: 50% PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein tthb187; PDBTitle: crystal structure of the thermus thermophilus cas3 hd domain in the2 presence of ni2+ Phyre2 PDB 1y5i chain C domain 1 Region: 4 - 73 Aligned: 70 Modelled: 70 Confidence: 5.7% Identity: 14% Fold: Heme-binding four-helical bundle Superfamily: Respiratory nitrate reductase 1 gamma chain Family: Respiratory nitrate reductase 1 gamma chain Phyre2 PDB 2ogi chain A Region: 71 - 76 Aligned: 6 Modelled: 6 Confidence: 5.2% Identity: 50% PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein sag1661; PDBTitle: crystal structure of a putative metal dependent phosphohydrolase2 (sag1661) from streptococcus agalactiae serogroup v at 1.85 a3 resolution Phyre2 PDB 2rdd chain B Region: 82 - 104 Aligned: 23 Modelled: 23 Confidence: 5.1% Identity: 4% PDB header:membrane protein/transport protein Chain: B: PDB Molecule:upf0092 membrane protein yajc; PDBTitle: x-ray crystal structure of acrb in complex with a novel2 transmembrane helix. Phyre2 1 c4a1oB_ 2 c1zczA_ 3 c1thzA_ 4 c2dyoB_ 5 c3rf1B_ 6 d1lira_ 7 c1bzgA_ 8 d2axti1 9 c2l2tA_ 10 c1gngX_ 11 c3skdA_ 12 d1y5ic1 13 c2ogiA_ 14 c2rddB_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c4a1oB_ 20.7 40 PDB header:transferase-hydrolase Chain: B: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of mycobacterium tuberculosis purh complexed with2 aicar and a novel nucleotide cfair, at 2.48 a resolution. 2 c1zczA_ 18.9 22 PDB header:transferase/hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of phosphoribosylaminoimidazolecarboxamide2 formyltransferase / imp cyclohydrolase (tm1249) from thermotoga3 maritima at 1.88 a resolution 3 c1thzA_ 18.5 40 PDB header:transferase, hydrolase Chain: A: PDB Molecule:bifunctional purine biosynthesis protein purh; PDBTitle: crystal structure of avian aicar transformylase in complex2 with a novel inhibitor identified by virtual ligand3 screening 4 c2dyoB_ 11.0 60 PDB header:protein turnover/protein turnover Chain: B: PDB Molecule:autophagy protein 16; PDBTitle: the crystal structure of saccharomyces cerevisiae atg5-2 atg16(1-57) complex 5 c3rf1B_ 9.1 31 PDB header:ligase Chain: B: PDB Molecule:glycyl-trna synthetase alpha subunit; PDBTitle: the crystal structure of glycyl-trna synthetase subunit alpha from2 campylobacter jejuni subsp. jejuni nctc 11168 6 d1lira_ 8.1 50 Fold:Knottins (small inhibitors, toxins, lectins) Superfamily:Scorpion toxin-like Family:Short-chain scorpion toxins 7 c1bzgA_ 8.0 57 PDB header:hormone Chain: A: PDB Molecule:parathyroid hormone-related protein; PDBTitle: the solution structure of human parathyroid hormone-related2 protein (1-34) in near-physiological solution, nmr, 303 structures 8 d2axti1 7.9 19 Fold:Single transmembrane helix Superfamily:Photosystem II reaction center protein I, PsbI Family:PsbI-like 9 c2l2tA_ 7.5 21 PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-4; PDBTitle: solution nmr structure of the erbb4 dimeric membrane domain 10 c1gngX_ 7.0 83 PDB header:transferase Chain: X: PDB Molecule:frattide; PDBTitle: glycogen synthase kinase-3 beta (gsk3) complex with frattide2 peptide 11 c3skdA_ 6.5 50 PDB header:hydrolase Chain: A: PDB Molecule:putative uncharacterized protein tthb187; PDBTitle: crystal structure of the thermus thermophilus cas3 hd domain in the2 presence of ni2+ 12 d1y5ic1 5.7 14 Fold:Heme-binding four-helical bundle Superfamily:Respiratory nitrate reductase 1 gamma chain Family:Respiratory nitrate reductase 1 gamma chain 13 c2ogiA_ 5.2 50 PDB header:hydrolase Chain: A: PDB Molecule:hypothetical protein sag1661; PDBTitle: crystal structure of a putative metal dependent phosphohydrolase2 (sag1661) from streptococcus agalactiae serogroup v at 1.85 a3 resolution 14 c2rddB_ 5.1 4 PDB header:membrane protein/transport protein Chain: B: PDB Molecule:upf0092 membrane protein yajc; PDBTitle: x-ray crystal structure of acrb in complex with a novel2 transmembrane helix.

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0