Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	R	S	L	K	K	G	P	F	I	D	L	H	L	L	K	K	V	E	K	A	V	E	S	G	D	K	K	P	L	R	T	W	S	R	R	S	T	I	F	P	N	M	I	G	L	T	I	A	V	H	N	G	R	Q	H	V	P	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?														?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.
Sequence		F	V	T	D	E	M	V	G	H	K	L	G	E	F	A	P	T	R	T	Y	R	G	H	A	A	D	K	K	A	K	K	K
Secondary structure
SS confidence
Disorder																			?			?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3bbn chain S Region: 1 - 92 Aligned: 92 Modelled: 92 Confidence: 100.0% Identity: 58% PDB header:ribosome Chain: S: PDB Molecule:ribosomal protein s19; PDBTitle: homology model for the spinach chloroplast 30s subunit2 fitted to 9.4a cryo-em map of the 70s chlororibosome. Phyre2 PDB 2uub chain S domain 1 Region: 2 - 81 Aligned: 80 Modelled: 80 Confidence: 100.0% Identity: 69% Fold: Ribosomal protein S19 Superfamily: Ribosomal protein S19 Family: Ribosomal protein S19 Phyre2 PDB 2gy9 chain S domain 1 Region: 3 - 81 Aligned: 79 Modelled: 79 Confidence: 100.0% Identity: 100% Fold: Ribosomal protein S19 Superfamily: Ribosomal protein S19 Family: Ribosomal protein S19 Phyre2 PDB 2zkq chain S Region: 3 - 85 Aligned: 83 Modelled: 83 Confidence: 100.0% Identity: 31% PDB header:ribosomal protein/rna Chain: S: PDB Molecule: PDBTitle: structure of a mammalian ribosomal 40s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map Phyre2 PDB 2xzm chain S Region: 3 - 85 Aligned: 83 Modelled: 83 Confidence: 100.0% Identity: 30% PDB header:ribosome Chain: S: PDB Molecule:rps15e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1 Phyre2 PDB 1s1h chain S Region: 7 - 81 Aligned: 75 Modelled: 75 Confidence: 100.0% Identity: 35% PDB header:ribosome Chain: S: PDB Molecule:40s ribosomal protein s15; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from2 yeast obtained by docking atomic models for rna and protein3 components into a 11.7 a cryo-em map. this file, 1s1h,4 contains 40s subunit. the 60s ribosomal subunit is in file5 1s1i. Phyre2 PDB 3izb chain R Region: 7 - 90 Aligned: 84 Modelled: 84 Confidence: 100.0% Identity: 32% PDB header:ribosome Chain: R: PDB Molecule:40s ribosomal protein rps15 (s19p); PDBTitle: localization of the small subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome Phyre2 PDB 1roc chain A Region: 41 - 60 Aligned: 20 Modelled: 20 Confidence: 18.4% Identity: 30% Fold: Immunoglobulin-like beta-sandwich Superfamily: ASF1-like Family: ASF1-like Phyre2 PDB 1t3q chain A domain 2 Region: 43 - 66 Aligned: 22 Modelled: 24 Confidence: 14.8% Identity: 18% Fold: beta-Grasp (ubiquitin-like) Superfamily: 2Fe-2S ferredoxin-like Family: 2Fe-2S ferredoxin domains from multidomain proteins Phyre2 PDB 2idc chain A Region: 41 - 60 Aligned: 20 Modelled: 20 Confidence: 12.5% Identity: 30% PDB header:replication/chaperone Chain: A: PDB Molecule:anti-silencing protein 1 and histone h3 chimera; PDBTitle: structure of the histone h3-asf1 chaperone interaction Phyre2 PDB 3ezo chain A Region: 62 - 75 Aligned: 14 Modelled: 14 Confidence: 11.9% Identity: 36% PDB header:transferase Chain: A: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: crystal structure of acyl-carrier-protein s-2 malonyltransferase from burkholderia pseudomallei 1710b Phyre2 PDB 1vlb chain A domain 2 Region: 44 - 66 Aligned: 21 Modelled: 23 Confidence: 11.2% Identity: 43% Fold: beta-Grasp (ubiquitin-like) Superfamily: 2Fe-2S ferredoxin-like Family: 2Fe-2S ferredoxin domains from multidomain proteins Phyre2 PDB 2i32 chain A domain 1 Region: 41 - 60 Aligned: 20 Modelled: 20 Confidence: 10.5% Identity: 25% Fold: Immunoglobulin-like beta-sandwich Superfamily: ASF1-like Family: ASF1-like Phyre2 PDB 2i32 chain A Region: 41 - 60 Aligned: 20 Modelled: 20 Confidence: 10.5% Identity: 25% PDB header:replication chaperone Chain: A: PDB Molecule:anti-silencing factor 1 paralog a; PDBTitle: structure of a human asf1a-hira complex and insights into2 specificity of histone chaperone complex assembly Phyre2 PDB 1li1 chain C domain 1 Region: 30 - 72 Aligned: 42 Modelled: 43 Confidence: 9.3% Identity: 14% Fold: C-type lectin-like Superfamily: C-type lectin-like Family: Noncollagenous (NC1) domain of collagen IV Phyre2 PDB 1mla chain A domain 1 Region: 66 - 75 Aligned: 10 Modelled: 10 Confidence: 7.9% Identity: 60% Fold: FabD/lysophospholipase-like Superfamily: FabD/lysophospholipase-like Family: FabD-like Phyre2 PDB 2cu9 chain A domain 1 Region: 43 - 60 Aligned: 18 Modelled: 18 Confidence: 7.8% Identity: 22% Fold: Immunoglobulin-like beta-sandwich Superfamily: ASF1-like Family: ASF1-like Phyre2 PDB 2cuy chain A Region: 66 - 75 Aligned: 10 Modelled: 10 Confidence: 7.5% Identity: 50% PDB header:transferase Chain: A: PDB Molecule:malonyl coa-[acyl carrier protein] transacylase; PDBTitle: crystal structure of malonyl coa-acyl carrier protein transacylase2 from thermus thermophilus hb8 Phyre2 PDB 1qub chain A domain 5 Region: 51 - 69 Aligned: 19 Modelled: 19 Confidence: 7.4% Identity: 16% Fold: Complement control module/SCR domain Superfamily: Complement control module/SCR domain Family: Complement control module/SCR domain Phyre2 PDB 3pnt chain D Region: 62 - 75 Aligned: 14 Modelled: 14 Confidence: 7.2% Identity: 43% PDB header:hydrolase/hydrolase inhibitor Chain: D: PDB Molecule:immunity factor for spn; PDBTitle: crystal structure of the streptococcus pyogenes nad+ glycohydrolase2 spn in complex with ifs, the immunity factor for spn Phyre2 1 c3bbnS_ 2 d2uubs1 3 d2gy9s1 4 c2zkqs_ 5 c2xzmS_ 6 c1s1hS_ 7 c3izbR_ 8 d1roca_ 9 d1t3qa2 10 c2idcA_ 11 c3ezoA_ 12 d1vlba2 13 d2i32a1 14 c2i32A_ 15 d1li1c1 16 d1mlaa1 17 d2cu9a1 18 c2cuyA_ 19 d1quba5 20 c3pntD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3bbnS_ 100.0 58 PDB header:ribosome Chain: S: PDB Molecule:ribosomal protein s19; PDBTitle: homology model for the spinach chloroplast 30s subunit2 fitted to 9.4a cryo-em map of the 70s chlororibosome. 2 d2uubs1 100.0 69 Fold:Ribosomal protein S19 Superfamily:Ribosomal protein S19 Family:Ribosomal protein S19 3 d2gy9s1 100.0 100 Fold:Ribosomal protein S19 Superfamily:Ribosomal protein S19 Family:Ribosomal protein S19 4 c2zkqs_ 100.0 31 PDB header:ribosomal protein/rna Chain: S: PDB Molecule: PDBTitle: structure of a mammalian ribosomal 40s subunit within an2 80s complex obtained by docking homology models of the rna3 and proteins into an 8.7 a cryo-em map 5 c2xzmS_ 100.0 30 PDB header:ribosome Chain: S: PDB Molecule:rps15e; PDBTitle: crystal structure of the eukaryotic 40s ribosomal2 subunit in complex with initiation factor 1. this file3 contains the 40s subunit and initiation factor for4 molecule 1 6 c1s1hS_ 100.0 35 PDB header:ribosome Chain: S: PDB Molecule:40s ribosomal protein s15; PDBTitle: structure of the ribosomal 80s-eef2-sordarin complex from2 yeast obtained by docking atomic models for rna and protein3 components into a 11.7 a cryo-em map. this file, 1s1h,4 contains 40s subunit. the 60s ribosomal subunit is in file5 1s1i. 7 c3izbR_ 100.0 32 PDB header:ribosome Chain: R: PDB Molecule:40s ribosomal protein rps15 (s19p); PDBTitle: localization of the small subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome 8 d1roca_ 18.4 30 Fold:Immunoglobulin-like beta-sandwich Superfamily:ASF1-like Family:ASF1-like 9 d1t3qa2 14.8 18 Fold:beta-Grasp (ubiquitin-like) Superfamily:2Fe-2S ferredoxin-like Family:2Fe-2S ferredoxin domains from multidomain proteins 10 c2idcA_ 12.5 30 PDB header:replication/chaperone Chain: A: PDB Molecule:anti-silencing protein 1 and histone h3 chimera; PDBTitle: structure of the histone h3-asf1 chaperone interaction 11 c3ezoA_ 11.9 36 PDB header:transferase Chain: A: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: crystal structure of acyl-carrier-protein s-2 malonyltransferase from burkholderia pseudomallei 1710b 12 d1vlba2 11.2 43 Fold:beta-Grasp (ubiquitin-like) Superfamily:2Fe-2S ferredoxin-like Family:2Fe-2S ferredoxin domains from multidomain proteins 13 d2i32a1 10.5 25 Fold:Immunoglobulin-like beta-sandwich Superfamily:ASF1-like Family:ASF1-like 14 c2i32A_ 10.5 25 PDB header:replication chaperone Chain: A: PDB Molecule:anti-silencing factor 1 paralog a; PDBTitle: structure of a human asf1a-hira complex and insights into2 specificity of histone chaperone complex assembly 15 d1li1c1 9.3 14 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Noncollagenous (NC1) domain of collagen IV 16 d1mlaa1 7.9 60 Fold:FabD/lysophospholipase-like Superfamily:FabD/lysophospholipase-like Family:FabD-like 17 d2cu9a1 7.8 22 Fold:Immunoglobulin-like beta-sandwich Superfamily:ASF1-like Family:ASF1-like 18 c2cuyA_ 7.5 50 PDB header:transferase Chain: A: PDB Molecule:malonyl coa-[acyl carrier protein] transacylase; PDBTitle: crystal structure of malonyl coa-acyl carrier protein transacylase2 from thermus thermophilus hb8 19 d1quba5 7.4 16 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 20 c3pntD_ 7.2 43 PDB header:hydrolase/hydrolase inhibitor Chain: D: PDB Molecule:immunity factor for spn; PDBTitle: crystal structure of the streptococcus pyogenes nad+ glycohydrolase2 spn in complex with ifs, the immunity factor for spn 21 d1nm2a1 not modelled 7.1 40 Fold:FabD/lysophospholipase-like Superfamily:FabD/lysophospholipase-like Family:FabD-like 22 c3qatB_ not modelled 7.1 50 PDB header:transferase Chain: B: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: crystal structure of acyl-carrier-protein-s-malonyltransferase from2 bartonella henselae 23 d1c1za5 not modelled 7.0 16 Fold:Complement control module/SCR domain Superfamily:Complement control module/SCR domain Family:Complement control module/SCR domain 24 d2b5ea2 not modelled 6.7 28 Fold:Thioredoxin fold Superfamily:Thioredoxin-like Family:PDI-like 25 c1t60R_ not modelled 6.6 15 PDB header:structural protein Chain: R: PDB Molecule:type iv collagen; PDBTitle: crystal structure of type iv collagen nc1 domain from2 bovine lens capsule 26 c2jfkD_ not modelled 6.6 70 PDB header:transferase Chain: D: PDB Molecule:fatty acid synthase; PDBTitle: structure of the mat domain of human fas with malonyl-coa 27 c3im8A_ not modelled 6.4 40 PDB header:transferase Chain: A: PDB Molecule:malonyl acyl carrier protein transacylase; PDBTitle: crystal structure of mcat from streptococcus pneumoniae 28 d1t61a1 not modelled 6.2 19 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Noncollagenous (NC1) domain of collagen IV 29 d1ex4a1 not modelled 6.1 83 Fold:SH3-like barrel Superfamily:DNA-binding domain of retroviral integrase Family:DNA-binding domain of retroviral integrase 30 d1x3ha2 not modelled 5.9 14 Fold:Glucocorticoid receptor-like (DNA-binding domain) Superfamily:Glucocorticoid receptor-like (DNA-binding domain) Family:LIM domain 31 c3im9A_ not modelled 5.7 50 PDB header:transferase Chain: A: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: crystal structure of mcat from staphylococcus aureus 32 d1c6vx_ not modelled 5.7 67 Fold:SH3-like barrel Superfamily:DNA-binding domain of retroviral integrase Family:DNA-binding domain of retroviral integrase 33 c1c6vX_ not modelled 5.7 67 PDB header:dna binding protein Chain: X: PDB Molecule:protein (siu89134); PDBTitle: siv integrase (catalytic domain + dna biding domain2 comprising residues 50-293) mutant with phe 185 replaced3 by his (f185h) 34 c2c2nA_ not modelled 5.7 50 PDB header:transferase Chain: A: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: structure of human mitochondrial malonyltransferase 35 c3hhdC_ not modelled 5.5 70 PDB header:transferase, hydrolase Chain: C: PDB Molecule:fatty acid synthase; PDBTitle: structure of the human fatty acid synthase ks-mat didomain2 as a framework for inhibitor design. 36 c1sqwA_ not modelled 5.5 33 PDB header:unknown function Chain: A: PDB Molecule:saccharomyces cerevisiae nip7p homolog; PDBTitle: crystal structure of kd93, a novel protein expressed in the2 human pro 37 c3g87A_ not modelled 5.4 60 PDB header:transferase Chain: A: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: crystal structure of malonyl coa-acyl carrier protein transacylase2 from burkholderia pseudomallei using dried seaweed as nucleant or3 protease 38 c2cdh9_ not modelled 5.4 40 PDB header:transferase Chain: 9: PDB Molecule:acetyl transferase; PDBTitle: architecture of the thermomyces lanuginosus fungal fatty2 acid synthase at 5 angstrom resolution. 39 d1d6za4 not modelled 5.2 9 Fold:N domain of copper amine oxidase-like Superfamily:Copper amine oxidase, domain N Family:Copper amine oxidase, domain N 40 c2qj3B_ not modelled 5.2 50 PDB header:transferase Chain: B: PDB Molecule:malonyl coa-acyl carrier protein transacylase; PDBTitle: mycobacterium tuberculosis fabd

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0