Job Description P05458 Confidence 100.00% Date Thu Jan 5 10:58:43 GMT 2012 Rank 3 Aligned Residues 930 % Identity 28% Template c2wk3A_ PDB info PDB header:hydrolase Chain: A: PDB Molecule:insulin degrading enzyme; PDBTitle: crystal structure of human insulin-degrading enzyme in2 complex with amyloid-beta (1-42) Resolution 2.59 Å

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		26	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	W	Q	P	I	Q	E	T	I	R	K	S	D	K	D	N	R	Q	Y	Q	A	I	R	L	D	N	G	M	V	V	L	L	V	S	D	P	Q	A	V	K	S	L	S	A	L	V	V	P	V	G	S	L	E	D	P	E	A	Y	Q	G	L	A	H	Y	L	E	H	M	S	L	M	G	S	K	K	Y	P	Q	A	D
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	I	K	R	I	G	N	H	I	T	K	S	P	E	D	K	R	E	Y	R	G	L	E	L	A	N	G	I	K	V	L	L	I	S	D	P	T	T	D	K	S	S	A	A	L	D	V	H	I	G	S	L	S	D	P	P	N	I	A	G	L	S	H	F	L	Q	H	M	L	F	L	G	T	K	K	Y	P	K	E	N
Template Known Secondary structure		T												T	T											T	T										T	T		S									S			G	G	G	S		T	T	S	T	T									G	G	G		B	S	S	S		S	T	T
Template Predicted Secondary structure
Template SS confidence
		46	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.
		106	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		S	L	A	E	Y	L	K	M	H	G	G	S	H	N	A	S	T	A	P	Y	R	T	A	F	Y	L	E	V	E	N	D	A	L	P	G	A	V	D	R	L	A	D	A	I	A	E	P	L	L	D	K	K	Y	A	E	R	E	R	N	A	V	N	A	E	L	T	M	A	R	T	R	D	G	M	R	M	A	Q	V	S
Query Conservation
Alig confidence
Template Conservation
Template Sequence		E	Y	S	Q	F	L	S	E	H	A	G	S	S	N	A	F	T	S	G	E	H	T	N	Y	Y	F	D	V	S	H	E	H	L	E	G	A	L	D	R	F	A	Q	F	F	L	S	P	L	F	D	E	S	A	K	D	R	E	V	N	A	V	D	S	E	H	E	K	N	V	M	N	D	A	W	R	L	F	Q	L	E
Template Known Secondary structure										T	T									S	S										G	G	G										G	G	G	T		B																						T	T
Template Predicted Secondary structure
Template SS confidence
		126	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.
		186	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210				.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.
Predicted Secondary structure																											.	.	.
Query SS confidence																											.	.	.
Query Sequence		A	E	T	I	N	P	A	H	P	G	S	K	F	S	G	G	N	L	E	T	L	S	D	K	P	.	.	.	G	N	P	V	Q	Q	A	L	K	D	F	H	E	K	Y	Y	S	A	N	L	M	K	A	V	I	Y	S	N	K	P	L	P	E	L	A	K	M	A	A	D	T	F	G	R	V	P	N	K	E	S	K	K
Query Conservation																											.	.	.
Alig confidence																											.	.	.
Template Conservation
Template Sequence		K	A	T	G	N	P	K	H	P	F	S	K	F	G	T	G	N	K	Y	T	L	E	T	R	P	N	Q	E	G	I	D	V	R	Q	E	L	L	K	F	H	S	A	Y	Y	S	S	N	L	M	A	V	V	V	L	G	R	E	S	L	D	D	L	T	N	L	V	V	K	L	F	S	E	V	E	N	K	N	V	P	L
Template Known Secondary structure				T	S		T	T	S	G	G	G	S			S							T						T	T																	G	G	G								S	S														T	T	S
Template Predicted Secondary structure
Template SS confidence
		206	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.
		263	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		P	E	I	T	V	P	V	V	T	D	A	Q	K	G	I	I	I	H	Y	V	P	A	L	P	R	K	V	L	R	V	E	F	R	I	D	N	N	S	A	K	F	R	S	K	T	D	E	L	I	T	Y	L	I	G	N	R	S	P	G	T	L	S	D	W	L	Q	K	Q	G	L	V	E	G	I	S	A	N	S	D	P
Query Conservation
Alig confidence
Template Conservation
Template Sequence		P	E	F	P	E	H	P	F	Q	E	E	H	L	K	Q	L	Y	K	I	V	P	I	K	D	I	R	N	L	Y	V	T	F	P	I	P	D	L	Q	K	Y	Y	K	S	N	P	G	H	Y	L	G	H	L	I	G	H	E	G	P	G	S	L	L	S	E	L	K	S	K	G	W	V	N	T	L	V	G	G	Q	K	E
Template Known Secondary structure						S		S			G	G	G	S	S								S	S	S														G	G	G	T	T	T											T			S	T	T									T	T	S		S
Template Predicted Secondary structure
Template SS confidence
		286	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.
		343	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		I	V	N	G	N	S	G	V	L	A	I	S	A	S	L	T	D	K	G	L	A	N	R	D	Q	V	V	A	A	I	F	S	Y	L	N	L	L	R	E	K	G	I	D	K	Q	Y	F	D	E	L	A	N	V	L	D	I	D	F	R	Y	P	S	I	T	R	D	M	D	Y	V	E	W	L	A	D	T	M	I	R	V
Query Conservation
Alig confidence						.
Template Conservation						.
Template Sequence		G	A	R	G	.	F	M	F	F	I	I	N	V	D	L	T	E	E	G	L	L	H	V	E	D	I	I	L	H	M	F	Q	Y	I	Q	K	L	R	A	E	G	P	Q	E	W	V	F	Q	E	L	K	D	L	N	A	V	A	F	R	F	K	D	K	E	R	P	R	G	Y	T	S	K	I	A	G	I	L	H	Y	Y
Template Known Secondary structure				T	T	.																T	T																																						T																	T	T	T	S
Template Predicted Secondary structure						.
Template SS confidence
		366	.	.	.		370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.
		423	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.			.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500
Predicted Secondary structure																																												.	.
Query SS confidence																																												.	.
Query Sequence		P	V	E	H	T	L	D	A	V	N	I	A	D	R	Y	D	A	K	A	V	K	E	R	L	A	M	M	T	P	Q	N	A	R	I	W	Y	I	S	P	K	E	P	.	.	H	N	K	T	A	Y	F	V	D	A	P	Y	Q	V	D	K	I	S	A	Q	T	F	A	D	W	Q	K	K	A	A	D	I	A	L	S	L
Query Conservation																																												.	.
Alig confidence																																												.	.
Template Conservation
Template Sequence		P	L	E	E	V	L	T	A	E	Y	L	L	E	E	F	R	P	D	L	I	E	M	V	L	D	K	L	R	P	E	N	V	R	V	A	I	V	S	K	S	F	E	G	K	T	D	R	T	E	E	W	Y	G	T	Q	Y	K	Q	E	A	I	P	D	E	V	I	K	K	W	Q	N	A	D	L	N	G	K	F	K	L
Template Known Secondary structure			G	G	G	T	T	T	T	T	T															T	T		S	G	G	G								G	G	G	T	T							T	T	T																			T					T	T
Template Predicted Secondary structure
Template SS confidence
		445	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480	.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.
		501	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.		.	.	.	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.	570	.	.	.	.	.	.	.	.	.
Predicted Secondary structure																								.
Query SS confidence																								.
Query Sequence		P	E	L	N	P	Y	I	P	D	D	F	S	L	I	K	S	E	K	K	Y	D	H	.	P	E	L	I	V	D	E	S	N	L	R	V	V	Y	A	P	S	R	Y	F	A	S	E	P	K	A	D	V	S	L	I	L	R	N	P	K	A	M	D	S	A	R	N	Q	V	M	F	A	L	N	D	Y	L	A	G	L	A
Query Conservation																								.
Alig confidence																								.																							.
Template Conservation																																															.
Template Sequence		P	T	K	N	E	F	I	P	T	N	F	E	I	L	P	L	E	K	E	A	T	P	Y	P	A	L	I	K	D	T	A	M	S	K	L	W	F	K	Q	D	D	K	F	F	L	.	P	K	A	N	L	N	F	E	F	F	S	P	F	A	Y	V	D	P	L	H	S	N	M	A	Y	L	Y	L	E	L	L	K	D	S
Template Known Secondary structure						T	T												T	T			S	S								S	S									S	S				.	S											G	G	G	T	S	S
Template Predicted Secondary structure																																															.
Template SS confidence
		525	.	.	.	.	530	.	.	.	.	.	.	.	.	.	540	.	.	.	.	.	.	.	.	.	550	.	.	.	.	.	.	.	.	.	560	.	.	.	.	.	.	.	.	.		570	.	.	.	.	.	.	.	.	.	580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.	.	.	600	.	.	.
		580	.	.	.	.	.	.	.	.	.	590	.	.	.	.	.	.	.		.	.	600	.	.	.	.	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.
Predicted Secondary structure																				.
Query SS confidence																				.
Query Sequence		L	D	Q	L	S	N	Q	A	S	V	G	G	I	S	F	S	T	N	.	A	N	N	G	L	M	V	N	A	N	G	Y	T	Q	R	L	P	Q	L	F	Q	A	L	L	E	G	Y	F	S	Y	T	A	T	E	D	Q	L	E	Q	A	K	S	W	Y	N	Q	M	M	D	S	A	E	K	G	K	A	F	E	Q	A	I
Query Conservation																				.
Alig confidence																				.
Template Conservation
Template Sequence		L	N	E	Y	A	Y	A	A	E	L	A	G	L	S	Y	D	L	Q	N	T	I	Y	G	M	Y	L	S	V	K	G	Y	N	D	K	Q	P	I	L	L	K	K	I	I	E	K	M	A	T	F	E	I	D	E	K	R	F	E	I	I	K	E	A	Y	M	R	S	L	N	N	F	R	A	E	Q	P	H	Q	H	A	M
Template Known Secondary structure												T	T									T	T	S									S	T	T													T	T																						G	G	G	S
Template Predicted Secondary structure
Template SS confidence
		604	.	.	.	.	.	610	.	.	.	.	.	.	.	.	.	620	.	.	.	.	.	.	.	.	.	630	.	.	.	.	.	.	.	.	.	640	.	.	.	.	.	.	.	.	.	650	.	.	.	.	.	.	.	.	.	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.
		659	660	.	.	.	.	.	.	.	.	.	670	.	.	.	.	.	.	.	.	.	680	.	.	.	.	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.								.	.	.	.	.	730	.
Predicted Secondary structure																																																																				.	.	.	.	.	.	.
Query SS confidence																																																																				.	.	.	.	.	.	.
Query Sequence		M	P	A	Q	M	L	S	Q	V	P	Y	F	S	R	D	E	R	R	K	I	L	P	S	I	T	L	K	E	V	L	A	Y	R	D	A	L	K	S	G	A	R	P	E	F	M	V	I	G	N	M	T	E	A	Q	A	T	T	L	A	R	D	V	Q	K	Q	L	.	.	.	.	.	.	.	G	A	D	G	S	E	W
Query Conservation																																																																				.	.	.	.	.	.	.
Alig confidence																																																																				.	.	.	.	.	.	.
Template Conservation
Template Sequence		Y	Y	L	R	L	L	M	T	E	V	A	W	T	K	D	E	L	K	E	A	L	D	D	V	T	L	P	R	L	K	A	F	I	P	Q	L	L	S	R	L	H	I	E	A	L	L	H	G	N	I	T	K	Q	A	A	L	G	I	M	Q	M	V	E	D	T	L	I	E	H	A	H	T	K	P	L	L	P	S	Q	L
Template Known Secondary structure									B	S	S												T	T																B										S																								B				G	G	G
Template Predicted Secondary structure
Template SS confidence
		684	.	.	.	.	.	690	.	.	.	.	.	.	.	.	.	700	.	.	.	.	.	.	.	.	.	710	.	.	.	.	.	.	.	.	.	720	.	.	.	.	.	.	.	.	.	730	.	.	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.
		732	.	.	.	.	.	.	.	740	.	.	.	.	.	.	.	.	.	750	.	.	.	.	.	.	.	.	.	760	.	.	.	.	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.
Predicted Secondary structure
Query SS confidence
Query Sequence		C	R	N	K	D	V	V	V	D	K	K	Q	S	V	I	F	E	K	A	G	N	S	T	D	S	A	L	A	A	V	F	V	P	T	G	Y	D	E	Y	T	S	S	A	Y	S	S	L	L	G	Q	I	V	Q	P	W	F	Y	N	Q	L	R	T	E	E	Q	L	G	Y	A	V	F	A	F	P	M	S	V	G	R	Q
Query Conservation
Alig confidence
Template Conservation
Template Sequence		V	R	Y	R	E	V	Q	L	P	D	R	G	W	F	V	Y	Q	Q	R	N	E	V	H	N	N	S	G	I	E	I	Y	Y	Q	T	D	M	Q	S	T	S	E	N	M	F	L	E	L	F	A	Q	I	I	S	E	P	A	F	N	T	L	R	T	K	E	Q	L	G	Y	I	V	F	S	G	P	R	R	A	N	G	I
Template Known Secondary structure						B	B				T	T										S	S		S	S																																				T	T	T	T				S										T	T
Template Predicted Secondary structure
Template SS confidence
		764	.	.	.	.	.	770	.	.	.	.	.	.	.	.	.	780	.	.	.	.	.	.	.	.	.	790	.	.	.	.	.	.	.	.	.	800	.	.	.	.	.	.	.	.	.	810	.	.	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.
		812	.	.	.	.	.	.	.	820	.	.	.	.	.	.	.	.	.	830	.	.	.	.	.	.	.	.	.	840	.	.	.	.	.	.	.	.	.	850	.	.	.	.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.
Predicted Secondary structure
Query SS confidence
Query Sequence		W	G	M	G	F	L	L	Q	S	N	D	K	Q	P	S	F	L	W	E	R	Y	K	A	F	F	P	T	A	E	A	K	L	R	A	M	K	P	D	E	F	A	Q	I	Q	Q	A	V	I	T	Q	M	L	Q	A	P	Q	T	L	G	E	E	A	S	K	L	S	K	D	F	D	R	G	N	M	R	F	D	S	R	D
Query Conservation
Alig confidence												.
Template Conservation												.
Template Sequence		Q	G	L	R	F	I	I	Q	S	E	.	K	P	P	H	Y	L	E	S	R	V	E	A	F	L	I	T	M	E	K	S	I	E	D	M	T	E	E	A	F	Q	K	H	I	Q	A	L	A	I	R	R	L	D	K	P	K	K	L	S	A	E	S	A	K	Y	W	G	E	I	I	S	Q	Q	Y	N	F	D	R	D	N
Template Known Secondary structure											S	.	S																							S																					S	S														T	T				T	T
Template Predicted Secondary structure												.
Template SS confidence
		844	.	.	.	.	.	850	.	.	.		.	.	.	.	.	.	860	.	.	.	.	.	.	.	.	.	870	.	.	.	.	.	.	.	.	.	880	.	.	.	.	.	.	.	.	.	890	.	.	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910	.	.	.	.	.	.	.	.	.	920	.	.
		892	.	.	.	.	.	.	.	900	.	.	.	.	.	.	.	.	.	910	.	.	.	.			.	.	.	.	.	920	.	.	.	.	.	.	.				.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.
Predicted Secondary structure																									.	.														.	.	.
Query SS confidence																									.	.														.	.	.
Query Sequence		K	I	V	A	Q	I	K	L	L	T	P	Q	K	L	A	D	F	F	H	Q	A	V	V	.	.	E	P	Q	G	M	A	I	L	S	Q	I	S	G	.	.	.	S	Q	N	G	K	A	E	Y	V	H	P	E	G	W	K	V	W	E	N	V	S	A	L	Q	Q	T	M	P	L	M	S
Query Conservation																									.	.														.	.	.
Alig confidence																									.	.														.	.	.
Template Conservation
Template Sequence		T	E	V	A	Y	L	K	T	L	T	K	E	D	I	I	K	F	Y	K	E	M	L	A	V	D	A	P	R	R	H	K	V	S	V	H	V	L	A	R	E	M	D	S	N	N	L	S	Q	A	P	A	L	P	Q	P	E	V	I	Q	N	M	T	E	F	K	R	G	L	P	L	F	P
Template Known Secondary structure								T	T														T	S	T	T		T	T											T	T																											T	S		B
Template Predicted Secondary structure
Template SS confidence
		923	.	.	.	.	.	.	930	.	.	.	.	.	.	.	.	.	940	.	.	.	.	.	.	.	.	.	950	.	.	.	.	.	.	.	.	.	960	.	.	.	.	.	.	.	.	.	970	.	.	.	.	.	.	.	.	.	980	.	.	.	.	.	.	.	.	.	990	.	.	.	.