Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	S	A	I	D	S	Q	L	P	S	S	S	G	Q	D	R	P	T	D	E	V	D	R	I	L	S	P	G	K	L	I	I	L	G	L	Q	H	V	L	V	M	Y	A	G	A	V	A	V	P	L	M	I	G	D	R	L	G	L	S	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?																																				?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	A	I	A	M	L	I	S	S	D	L	F	C	C	G	I	V	T	L	L	Q	C	I	G	I	G	R	F	M	G	I	R	L	P	V	I	M	S	V	T	F	A	A	V	T	P	M	I	A	I	G	M	N	P	D	I	G	L	L	G
Secondary structure
SS confidence
Disorder																										?										?																?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	F	G	A	T	I	A	A	G	F	I	T	T	L	L	A	P	L	I	G	R	L	M	P	L	F	P	P	L	V	T	G	V	V	I	T	S	I	G	L	S	I	I	Q	V	G	I	D	W	A	A	G	G	K	G	N	P	Q	Y	G
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		N	P	V	Y	L	G	I	S	F	A	V	L	I	F	I	L	L	I	T	R	Y	A	K	G	F	M	S	N	V	A	V	L	L	G	I	V	F	G	F	L	L	S	W	M	M	N	E	V	N	L	S	G	L	H	D	A	S	W	F	A
Secondary structure
SS confidence
Disorder																						?		?	?	?			?	?																					?			?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		I	V	T	P	M	S	F	G	M	P	I	F	D	P	V	S	I	L	T	M	T	A	V	L	I	I	V	F	I	E	S	M	G	M	F	L	A	L	G	E	I	V	G	R	K	L	S	S	H	D	I	I	R	G	L	R	V	D	G	V
Secondary structure
SS confidence
Disorder																																											?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		G	T	M	I	G	G	T	F	N	S	F	P	H	T	S	F	S	Q	N	V	G	L	V	S	V	T	R	V	H	S	R	W	V	C	I	S	S	G	I	I	L	I	L	F	G	M	V	P	K	M	A	V	L	V	A	S	I	P	Q	F
Secondary structure
SS confidence
Disorder										?		?		?	?	?	?	?	?						?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	L	G	G	A	G	L	V	M	F	G	M	V	L	A	T	G	I	R	I	L	S	R	C	N	Y	T	T	N	R	Y	N	L	Y	I	V	A	I	S	L	G	V	G	M	T	P	T	L	S	H	D	F	F	S	K	L	P	A	V	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		Q	P	L	L	H	S	G	I	M	L	A	T	L	S	A	V	V	L	N	V	F	F	N	G	Y	Q	H	H	A	D	L	V	K	E	S	V	S	D	K	D	L	K	V	R	T	V	R	M	W	L	L	M	R	K	L	K	K	N	E	H
Secondary structure
SS confidence
Disorder						?																					?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?								?	?	?	?	?	?	?
Disorder confidence
		.	.
Sequence		G	E
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3qe7 chain A Region: 17 - 443 Aligned: 397 Modelled: 427 Confidence: 100.0% Identity: 28% PDB header:transport protein Chain: A: PDB Molecule:uracil permease; PDBTitle: crystal structure of uracil transporter--uraa Phyre2 PDB 1pw4 chain A Region: 8 - 458 Aligned: 424 Modelled: 430 Confidence: 96.1% Identity: 9% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 3lpz chain A Region: 299 - 315 Aligned: 17 Modelled: 17 Confidence: 14.2% Identity: 18% PDB header:protein transport Chain: A: PDB Molecule:get4 (yor164c homolog); PDBTitle: crystal structure of c. therm. get4 Phyre2 PDB 1pv7 chain A Region: 28 - 456 Aligned: 406 Modelled: 412 Confidence: 11.1% Identity: 8% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: LacY-like proton/sugar symporter Phyre2 PDB 2rng chain A Region: 465 - 481 Aligned: 17 Modelled: 17 Confidence: 10.1% Identity: 29% PDB header:antimicrobial protein Chain: A: PDB Molecule:big defensin; PDBTitle: solution structure of big defensin Phyre2 PDB 3org chain B Region: 288 - 444 Aligned: 157 Modelled: 157 Confidence: 7.9% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:cmclc; PDBTitle: crystal structure of a eukaryotic clc transporter Phyre2 PDB 2xut chain C Region: 27 - 210 Aligned: 179 Modelled: 184 Confidence: 7.6% Identity: 9% PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter. Phyre2 PDB 3dla chain D Region: 413 - 480 Aligned: 68 Modelled: 68 Confidence: 7.5% Identity: 10% PDB header:ligase Chain: D: PDB Molecule:glutamine-dependent nad(+) synthetase; PDBTitle: x-ray crystal structure of glutamine-dependent nad+ synthetase from2 mycobacterium tuberculosis bound to naad+ and don Phyre2 PDB 1dxz chain A Region: 23 - 46 Aligned: 24 Modelled: 24 Confidence: 7.5% Identity: 13% PDB header:transmembrane protein Chain: A: PDB Molecule:acetylcholine receptor protein, alpha chain; PDBTitle: m2 transmembrane segment of alpha-subunit of nicotinic2 acetylcholine receptor from torpedo californica, nmr, 203 structures Phyre2 PDB 1oed chain B Region: 389 - 480 Aligned: 91 Modelled: 92 Confidence: 7.2% Identity: 14% Fold: Neurotransmitter-gated ion-channel transmembrane pore Superfamily: Neurotransmitter-gated ion-channel transmembrane pore Family: Neurotransmitter-gated ion-channel transmembrane pore Phyre2 PDB 2la2 chain A Region: 468 - 481 Aligned: 14 Modelled: 14 Confidence: 6.9% Identity: 21% PDB header:antimicrobial protein Chain: A: PDB Molecule:cecropin; PDBTitle: solution structure of papiliocin isolated from the swallowtail2 butterfly, papilio xuthus Phyre2 PDB 2knc chain B Region: 461 - 482 Aligned: 22 Modelled: 22 Confidence: 6.2% Identity: 9% PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2gfp chain A Region: 30 - 437 Aligned: 367 Modelled: 377 Confidence: 6.1% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 2oar chain A Region: 339 - 474 Aligned: 112 Modelled: 115 Confidence: 6.1% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: mechanosensitive channel of large conductance (mscl) Phyre2 PDB 3hd6 chain A Region: 300 - 457 Aligned: 157 Modelled: 158 Confidence: 5.9% Identity: 10% PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg Phyre2 PDB 3dhw chain A domain 1 Region: 350 - 474 Aligned: 125 Modelled: 125 Confidence: 5.8% Identity: 7% Fold: MetI-like Superfamily: MetI-like Family: MetI-like Phyre2 PDB 1u0s chain A Region: 458 - 477 Aligned: 20 Modelled: 20 Confidence: 5.5% Identity: 20% Fold: Ferredoxin-like Superfamily: CheY-binding domain of CheA Family: CheY-binding domain of CheA Phyre2 PDB 2nny chain A Region: 446 - 482 Aligned: 37 Modelled: 37 Confidence: 5.4% Identity: 5% PDB header:transcription/dna Chain: A: PDB Molecule:c-ets-1 protein; PDBTitle: crystal structure of the ets1 dimer dna complex. Phyre2 PDB 1gvj chain A Region: 446 - 482 Aligned: 37 Modelled: 37 Confidence: 5.2% Identity: 5% Fold: DNA/RNA-binding 3-helical bundle Superfamily: "Winged helix" DNA-binding domain Family: ets domain Phyre2 1 c3qe7A_ 2 d1pw4a_ 3 c3lpzA_ 4 d1pv7a_ 5 c2rngA_ 6 c3orgB_ 7 c2xutC_ 8 c3dlaD_ 9 c1dxzA_ 10 d1oedb_ 11 c2la2A_ 12 c2kncB_ 13 c2gfpA_ 14 c2oarA_ 15 c3hd6A_ 16 d3dhwa1 17 d1u0sa_ 18 c2nnyA_ 19 d1gvja_

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3qe7A_ 100.0 28 PDB header:transport protein Chain: A: PDB Molecule:uracil permease; PDBTitle: crystal structure of uracil transporter--uraa 2 d1pw4a_ 96.1 9 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:Glycerol-3-phosphate transporter 3 c3lpzA_ 14.2 18 PDB header:protein transport Chain: A: PDB Molecule:get4 (yor164c homolog); PDBTitle: crystal structure of c. therm. get4 4 d1pv7a_ 11.1 8 Fold:MFS general substrate transporter Superfamily:MFS general substrate transporter Family:LacY-like proton/sugar symporter 5 c2rngA_ 10.1 29 PDB header:antimicrobial protein Chain: A: PDB Molecule:big defensin; PDBTitle: solution structure of big defensin 6 c3orgB_ 7.9 15 PDB header:transport protein Chain: B: PDB Molecule:cmclc; PDBTitle: crystal structure of a eukaryotic clc transporter 7 c2xutC_ 7.6 9 PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot)2 family transporter. 8 c3dlaD_ 7.5 10 PDB header:ligase Chain: D: PDB Molecule:glutamine-dependent nad(+) synthetase; PDBTitle: x-ray crystal structure of glutamine-dependent nad+ synthetase from2 mycobacterium tuberculosis bound to naad+ and don 9 c1dxzA_ 7.5 13 PDB header:transmembrane protein Chain: A: PDB Molecule:acetylcholine receptor protein, alpha chain; PDBTitle: m2 transmembrane segment of alpha-subunit of nicotinic2 acetylcholine receptor from torpedo californica, nmr, 203 structures 10 d1oedb_ 7.2 14 Fold:Neurotransmitter-gated ion-channel transmembrane pore Superfamily:Neurotransmitter-gated ion-channel transmembrane pore Family:Neurotransmitter-gated ion-channel transmembrane pore 11 c2la2A_ 6.9 21 PDB header:antimicrobial protein Chain: A: PDB Molecule:cecropin; PDBTitle: solution structure of papiliocin isolated from the swallowtail2 butterfly, papilio xuthus 12 c2kncB_ 6.2 9 PDB header:cell adhesion Chain: B: PDB Molecule:integrin beta-3; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex 13 c2gfpA_ 6.1 12 PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli 14 c2oarA_ 6.1 9 PDB header:membrane protein Chain: A: PDB Molecule:large-conductance mechanosensitive channel; PDBTitle: mechanosensitive channel of large conductance (mscl) 15 c3hd6A_ 5.9 10 PDB header:membrane protein, transport protein Chain: A: PDB Molecule:ammonium transporter rh type c; PDBTitle: crystal structure of the human rhesus glycoprotein rhcg 16 d3dhwa1 5.8 7 Fold:MetI-like Superfamily:MetI-like Family:MetI-like 17 d1u0sa_ 5.5 20 Fold:Ferredoxin-like Superfamily:CheY-binding domain of CheA Family:CheY-binding domain of CheA 18 c2nnyA_ 5.4 5 PDB header:transcription/dna Chain: A: PDB Molecule:c-ets-1 protein; PDBTitle: crystal structure of the ets1 dimer dna complex. 19 d1gvja_ 5.2 5 Fold:DNA/RNA-binding 3-helical bundle Superfamily:"Winged helix" DNA-binding domain Family:ets domain

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0