Secondary structure and disorder prediction

		1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	K	K	I	D	V	K	I	L	D	P	R	V	G	K	E	F	P	L	P	T	Y	A	T	S	G	S	A	G	L	D	L	R	A	C	L	N	D	A	V	E	L	A	P	G	D	T	T	L	V	P	T	G	L	A	I	H	I	A	D
Secondary structure
SS confidence
Disorder		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	S	L	A	A	M	M	L	P	R	S	G	L	G	H	K	H	G	I	V	L	G	N	L	V	G	L	I	D	S	D	Y	Q	G	Q	L	M	I	S	V	W	N	R	G	Q	D	S	F	T	I	Q	P	G	E	R	I	A	Q	M	I
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.
Sequence		F	V	P	V	V	Q	A	E	F	N	L	V	E	D	F	D	A	T	D	R	G	E	G	G	F	G	H	S	G	R	Q
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key
High(9)											Low (0)

?	Disordered
	Alpha helix
	Beta strand

Domain analysis

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank Aligned region

PDB 3ehw chain A Region: 6 - 150 Aligned: 140 Modelled: 145 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:dutp pyrophosphatase; PDBTitle: human dutpase in complex with alpha,beta-imido-dutp and mg2+:2 visualization of the full-length c-termini in all monomers and3 suggestion for an additional metal ion binding site Phyre2 PDB 1six chain A Region: 2 - 149 Aligned: 145 Modelled: 148 Confidence: 100.0% Identity: 32% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1rnj chain A Region: 1 - 136 Aligned: 136 Modelled: 136 Confidence: 100.0% Identity: 99% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1euw chain A Region: 1 - 135 Aligned: 135 Modelled: 135 Confidence: 100.0% Identity: 100% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3tqz chain A Region: 2 - 136 Aligned: 135 Modelled: 135 Confidence: 100.0% Identity: 61% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii Phyre2 PDB 3ehw chain A domain 1 Region: 6 - 146 Aligned: 136 Modelled: 141 Confidence: 100.0% Identity: 32% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3f4f chain B Region: 8 - 146 Aligned: 134 Modelled: 139 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of dut1p, a dutpase from saccharomyces cerevisiae Phyre2 PDB 1f7r chain A Region: 13 - 149 Aligned: 129 Modelled: 135 Confidence: 100.0% Identity: 26% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3mbq chain C Region: 5 - 145 Aligned: 135 Modelled: 141 Confidence: 100.0% Identity: 44% PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form Phyre2 PDB 1sjn chain A Region: 2 - 137 Aligned: 129 Modelled: 136 Confidence: 100.0% Identity: 34% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 3c3i chain A Region: 7 - 137 Aligned: 126 Modelled: 131 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 3ca9 chain A Region: 1 - 134 Aligned: 125 Modelled: 134 Confidence: 100.0% Identity: 32% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase Phyre2 PDB 3lqw chain A Region: 8 - 138 Aligned: 126 Modelled: 131 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate2 nucleotidohydrolase from entamoeba histolytica Phyre2 PDB 1vyq chain A domain 1 Region: 6 - 138 Aligned: 129 Modelled: 133 Confidence: 100.0% Identity: 26% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 1q5u chain Z Region: 5 - 136 Aligned: 127 Modelled: 132 Confidence: 100.0% Identity: 29% Fold: beta-clip Superfamily: dUTPase-like Family: dUTPase-like Phyre2 PDB 2p9o chain B Region: 3 - 134 Aligned: 125 Modelled: 132 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: B: PDB Molecule:dutp pyrophosphatase-like protein; PDBTitle: structure of dutpase from arabidopsis thaliana Phyre2 PDB 3h6x chain A Region: 3 - 128 Aligned: 122 Modelled: 124 Confidence: 100.0% Identity: 31% PDB header:hydrolase Chain: A: PDB Molecule:dutpase; PDBTitle: crystal structure of dutpase from streptococcus mutans Phyre2 PDB 2okd chain B Region: 8 - 135 Aligned: 122 Modelled: 128 Confidence: 100.0% Identity: 29% PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: high resolution crystal structures of vaccinia virus dutpase Phyre2 PDB 3ecy chain A Region: 8 - 135 Aligned: 116 Modelled: 128 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: A: PDB Molecule:cg4584-pa, isoform a (bcdna.ld08534); PDBTitle: crystal structural analysis of drosophila melanogaster dutpase Phyre2 PDB 2baz chain A Region: 6 - 135 Aligned: 126 Modelled: 128 Confidence: 100.0% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein bsu20020; PDBTitle: structure of yoss, a putative dutpase from bacillus subtilis Phyre2 1 c3ehwA_ 2 d1sixa_ 3 d1rnja_ 4 d1euwa_ 5 c3tqzA_ 6 d3ehwa1 7 c3f4fB_ 8 d1f7ra_ 9 c3mbqC_ 10 d1sjna_ 11 c3c3iA_ 12 c3ca9A_ 13 c3lqwA_ 14 d1vyqa1 15 d1q5uz_ 16 c2p9oB_ 17 c3h6xA_ 18 c2okdB_ 19 c3ecyA_ 20 c2bazA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66

Detailed template information

# Template Alignment Coverage 3D Model Confidence % i.d. Template Information

1 c3ehwA_ 100.0 32 PDB header:hydrolase Chain: A: PDB Molecule:dutp pyrophosphatase; PDBTitle: human dutpase in complex with alpha,beta-imido-dutp and mg2+:2 visualization of the full-length c-termini in all monomers and3 suggestion for an additional metal ion binding site 2 d1sixa_ 100.0 32 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 3 d1rnja_ 100.0 99 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 4 d1euwa_ 100.0 100 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 5 c3tqzA_ 100.0 61 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: structure of a deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)2 from coxiella burnetii 6 d3ehwa1 100.0 32 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 7 c3f4fB_ 100.0 29 PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of dut1p, a dutpase from saccharomyces cerevisiae 8 d1f7ra_ 100.0 26 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 9 c3mbqC_ 100.0 44 PDB header:hydrolase Chain: C: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate nucleotidohydrolase2 from brucella melitensis, orthorhombic crystal form 10 d1sjna_ 100.0 34 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 11 c3c3iA_ 100.0 31 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase 12 c3ca9A_ 100.0 32 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine triphosphatase; PDBTitle: evolution of chlorella virus dutpase 13 c3lqwA_ 100.0 29 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: crystal structure of deoxyuridine 5-triphosphate2 nucleotidohydrolase from entamoeba histolytica 14 d1vyqa1 100.0 26 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 15 d1q5uz_ 100.0 29 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 16 c2p9oB_ 100.0 31 PDB header:hydrolase Chain: B: PDB Molecule:dutp pyrophosphatase-like protein; PDBTitle: structure of dutpase from arabidopsis thaliana 17 c3h6xA_ 100.0 31 PDB header:hydrolase Chain: A: PDB Molecule:dutpase; PDBTitle: crystal structure of dutpase from streptococcus mutans 18 c2okdB_ 100.0 29 PDB header:hydrolase Chain: B: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: high resolution crystal structures of vaccinia virus dutpase 19 c3ecyA_ 100.0 23 PDB header:hydrolase Chain: A: PDB Molecule:cg4584-pa, isoform a (bcdna.ld08534); PDBTitle: crystal structural analysis of drosophila melanogaster dutpase 20 c2bazA_ 100.0 22 PDB header:unknown function Chain: A: PDB Molecule:hypothetical protein bsu20020; PDBTitle: structure of yoss, a putative dutpase from bacillus subtilis 21 d1f7da_ not modelled 100.0 26 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 22 d1duna_ not modelled 100.0 21 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 23 c2d4nA_ not modelled 100.0 35 PDB header:hydrolase Chain: A: PDB Molecule:du; PDBTitle: crystal structure of m-pmv dutpase complexed with dupnpp, substrate2 analogue 24 d2bsya2 not modelled 100.0 20 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 25 c2bt1A_ not modelled 99.9 20 PDB header:hydrolase Chain: A: PDB Molecule:deoxyuridine 5'-triphosphate nucleotidohydrolase; PDBTitle: epstein barr virus dutpase in complex with a,b-imino dutp 26 c2qxxA_ not modelled 99.9 24 PDB header:hydrolase Chain: A: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase: dutpase from mycobacterium tuberculosis2 in complex with dttp 27 d2bsya1 not modelled 99.9 21 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 28 d1xs1a_ not modelled 99.9 22 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 29 c2qlpC_ not modelled 99.9 26 PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: bifunctional dctp deaminase:dutpase from mycobacterium tuberculosis,2 apo form 30 c3km3B_ not modelled 99.9 23 PDB header:hydrolase Chain: B: PDB Molecule:deoxycytidine triphosphate deaminase; PDBTitle: crystal structure of eoxycytidine triphosphate deaminase from2 anaplasma phagocytophilum at 2.1a resolution 31 d1pkha_ not modelled 99.9 25 Fold:beta-clip Superfamily:dUTPase-like Family:dUTPase-like 32 c2yzjB_ not modelled 99.9 22 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:167aa long hypothetical dutpase; PDBTitle: crystal structure of dctp deaminase from sulfolobus tokodaii 33 c2r9qD_ not modelled 99.8 25 PDB header:hydrolase Chain: D: PDB Molecule:2'-deoxycytidine 5'-triphosphate deaminase; PDBTitle: crystal structure of 2'-deoxycytidine 5'-triphosphate deaminase from2 agrobacterium tumefaciens 34 d1tula_ not modelled 44.2 18 Fold:beta-clip Superfamily:Tlp20, baculovirus telokin-like protein Family:Tlp20, baculovirus telokin-like protein 35 d1kwga1 not modelled 17.6 19 Fold:Glycosyl hydrolase domain Superfamily:Glycosyl hydrolase domain Family:alpha-Amylases, C-terminal beta-sheet domain 36 c3kvpB_ not modelled 13.8 18 PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein ymzc; PDBTitle: crystal structure of uncharacterized protein ymzc precursor2 from bacillus subtilis, northeast structural genomics3 consortium target sr378a 37 d1ng2a2 not modelled 12.8 18 Fold:SH3-like barrel Superfamily:SH3-domain Family:SH3-domain 38 d1v7ra_ not modelled 12.3 38 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 39 c3gzuB_ not modelled 12.2 22 PDB header:virus Chain: B: PDB Molecule:inner capsid protein vp2; PDBTitle: vp7 recoated rotavirus dlp 40 c3h0dB_ not modelled 12.1 44 PDB header:transcription/dna Chain: B: PDB Molecule:ctsr; PDBTitle: crystal structure of ctsr in complex with a 26bp dna duplex 41 d1pmia_ not modelled 12.1 14 Fold:Double-stranded beta-helix Superfamily:RmlC-like cupins Family:Type I phosphomannose isomerase 42 c3kz4A_ not modelled 11.5 20 PDB header:virus Chain: A: PDB Molecule:inner capsid protein vp2; PDBTitle: crystal structure of the rotavirus double layered particle 43 d1k7ka_ not modelled 10.9 38 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 44 d1dj2a_ not modelled 10.9 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 45 d1dj3a_ not modelled 10.7 11 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 46 c3tquD_ not modelled 10.7 38 PDB header:hydrolase Chain: D: PDB Molecule:non-canonical purine ntp pyrophosphatase; PDBTitle: structure of a ham1 protein from coxiella burnetii 47 d1qf5a_ not modelled 10.3 28 Fold:P-loop containing nucleoside triphosphate hydrolases Superfamily:P-loop containing nucleoside triphosphate hydrolases Family:Nitrogenase iron protein-like 48 d2cara1 not modelled 9.7 44 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 49 c3ld1A_ not modelled 8.3 27 PDB header:hydrolase Chain: A: PDB Molecule:replicase polyprotein 1a; PDBTitle: crystal structure of ibv nsp2a 50 d1o51a_ not modelled 8.0 67 Fold:Ferredoxin-like Superfamily:GlnB-like Family:DUF190/COG1993 51 d1boba_ not modelled 7.5 33 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 52 d3c0na1 not modelled 7.2 18 Fold:C-type lectin-like Superfamily:C-type lectin-like Family:Aerolysin/Pertussis toxin (APT) domain 53 d1vp2a_ not modelled 6.9 35 Fold:Anticodon-binding domain-like Superfamily:ITPase-like Family:ITPase (Ham1) 54 c1w1fA_ not modelled 6.2 25 PDB header:sh3-domain Chain: A: PDB Molecule:tyrosine-protein kinase lyn; PDBTitle: sh3 domain of human lyn tyrosine kinase 55 d1uwfa1 not modelled 6.1 17 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Bacterial adhesins Family:Pilus subunits 56 d1x7fa1 not modelled 5.9 31 Fold:Cyclophilin-like Superfamily:Cyclophilin-like Family:Outer surface protein, C-terminal domain 57 c3nrfA_ not modelled 5.8 11 PDB header:structural genomics, unknown function Chain: A: PDB Molecule:apag protein; PDBTitle: crystal structure of an apag protein (pa1934) from pseudomonas2 aeruginosa pao1 at 1.50 a resolution 58 d1e5ba_ not modelled 5.8 6 Fold:Common fold of diphtheria toxin/transcription factors/cytochrome f Superfamily:Carbohydrate-binding domain Family:Cellulose-binding domain family II 59 c3d82A_ not modelled 5.6 16 PDB header:metal binding protein Chain: A: PDB Molecule:cupin 2, conserved barrel domain protein; PDBTitle: crystal structure of a cupin-2 domain containing protein (sfri_3543)2 from shewanella frigidimarina ncimb 400 at 2.05 a resolution 60 d1qqfa_ not modelled 5.3 21 Fold:alpha/alpha toroid Superfamily:Terpenoid cyclases/Protein prenyltransferases Family:Complement components 61 c2oqbA_ not modelled 5.3 26 PDB header:transferase,gene regulation Chain: A: PDB Molecule:histone-arginine methyltransferase carm1; PDBTitle: crystal structure of the n-terminal domain of coactivator-associated2 methyltransferase 1 (carm1) 62 d1cm0a_ not modelled 5.2 18 Fold:Acyl-CoA N-acyltransferases (Nat) Superfamily:Acyl-CoA N-acyltransferases (Nat) Family:N-acetyl transferase, NAT 63 c3h1yA_ not modelled 5.2 14 PDB header:isomerase Chain: A: PDB Molecule:mannose-6-phosphate isomerase; PDBTitle: crystal structure of mannose 6-phosphate isomerase from2 salmonella typhimurium bound to substrate (f6p)and metal3 atom (zn) 64 c1xopA_ not modelled 5.1 25 PDB header:viral protein Chain: A: PDB Molecule:hemagglutinin; PDBTitle: nmr structure of g1v mutant of influenza hemagglutinin2 fusion peptide in dpc micelles at ph 5 65 d2ot2a1 not modelled 5.1 29 Fold:OB-fold Superfamily:HupF/HypC-like Family:HupF/HypC-like 66 c3mwxA_ not modelled 5.1 26 PDB header:isomerase Chain: A: PDB Molecule:aldose 1-epimerase; PDBTitle: crystal structure of a putative galactose mutarotase (bsu18360) from2 bacillus subtilis at 1.45 a resolution

Binding site prediction

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

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Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group Imperial College London Lawrence Kelley, Benjamin Jefferys Disclaimer Terms and Conditions	Component software Template detection: HHpred 1.51 Secondary structure prediction: Psi-pred 2.5 Disorder prediction: Disopred 2.4 Transmembrane prediction: Memsat_SVM Multi-template modelling and ab initio: Poing 1.0