Job Description P07650 Confidence 100.00% Date Wed Jan 25 15:20:12 GMT 2012 Rank 2 Aligned Residues 434 % Identity 40% Template c2j0fC_ PDB info PDB header:transferase Chain: C: PDB Molecule:thymidine phosphorylase; PDBTitle: structural basis for non-competitive product inhibition in2 human thymidine phosphorylase: implication for drug design Resolution 2.31 Å

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		3	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		L	A	Q	E	I	I	R	K	K	R	D	G	H	A	L	S	D	E	E	I	R	F	F	I	N	G	I	R	D	N	T	I	S	E	G	Q	I	A	A	L	A	M	T	I	F	F	H	D	M	T	M	P	E	R	V	S	L	T	M	A	M	R	D	S	G	T	V	L	D	W	K	S	L	H	L	N	G	P	I	V
Query Conservation
Alig confidence																																																																										.
Template Conservation																																																																										.
Template Sequence		Q	L	P	E	L	I	R	M	K	R	D	G	G	R	L	S	E	A	D	I	R	G	F	V	A	A	V	V	N	G	S	A	Q	G	A	Q	I	G	A	M	L	M	A	I	R	L	R	G	M	D	L	E	E	T	S	V	L	T	Q	A	L	A	Q	S	G	Q	Q	L	E	W	P	E	.	A	W	R	Q	Q	L	V
Template Known Secondary structure												T	T																		T		S																															T	T	S							G	.	G	G	T	T	T	B
Template Predicted Secondary structure																																																																										.
Template SS confidence
		35	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60	.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.		.	.	.	110	.	.	.
		83	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		D	K	H	S	T	G	G	V	G	D	V	T	S	L	M	L	G	P	M	V	A	A	C	G	G	Y	I	P	M	I	S	G	R	G	L	G	H	T	G	G	T	L	D	K	L	E	S	I	P	G	F	D	I	F	P	D	D	N	R	F	R	E	I	I	K	D	V	G	V	A	I	I	G	Q	T	S	S	L	A	P
Query Conservation
Alig confidence
Template Conservation
Template Sequence		D	K	H	S	T	G	G	V	G	D	K	V	S	L	V	L	A	P	A	L	A	A	C	G	C	K	V	P	M	I	S	G	R	G	L	G	H	T	G	G	T	L	D	K	L	E	S	I	P	G	F	N	V	I	Q	S	P	E	Q	M	Q	V	L	L	D	Q	A	G	C	C	I	V	G	Q	S	E	Q	L	V	P
Template Known Secondary structure						S			T	T														T	T		B									B	T	T	B								T	T	S	T	T																	T	S								S	S	S
Template Predicted Secondary structure
Template SS confidence
		114	.	.	.	.	.	120	.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.
		163	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180	.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		A	D	K	R	F	Y	A	T	R	D	I	T	A	T	V	D	S	I	P	L	I	T	A	S	I	L	A	K	K	L	A	E	G	L	D	A	L	V	M	D	V	K	V	G	S	G	A	F	M	P	T	Y	E	L	S	E	A	L	A	E	A	I	V	G	V	A	N	G	A	G	V	R	T	T	A	L	L	T	D	M
Query Conservation
Alig confidence
Template Conservation
Template Sequence		A	D	G	I	L	Y	A	A	R	D	V	T	A	T	V	D	S	L	P	L	I	T	A	S	I	L	S	K	K	L	V	E	G	L	S	A	L	V	V	D	V	K	F	G	A	G	A	V	F	P	N	Q	E	Q	A	R	E	L	A	K	T	L	V	G	V	G	A	S	L	G	L	R	V	A	A	A	L	T	A	M
Template Known Secondary structure												T	T	T		S	S																T	T		S									S	T	T	S	S	S		S																		T	T
Template Predicted Secondary structure
Template SS confidence
		194	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240	.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.
		243	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		N	Q	V	L	A	S	S	A	G	N	A	V	E	V	R	E	A	V	Q	F	L	T	G	E	Y	R	N	P	R	L	F	D	V	T	M	A	L	C	V	E	M	L	I	S	G	K	L	A	K	D	D	A	E	A	R	A	K	L	Q	A	V	L	D	N	G	K	A	A	E	V	F	G	R	M	V	A	A	Q	K	G
Query Conservation
Alig confidence																										.
Template Conservation																										.
Template Sequence		D	K	P	L	G	R	C	V	G	H	A	L	E	V	E	E	A	L	L	C	M	D	G	A	.	G	P	P	D	L	R	D	L	V	T	T	L	G	G	A	L	L	W	L	S	G	H	A	G	T	Q	A	Q	G	A	A	R	V	A	A	A	L	D	D	G	S	A	L	G	R	F	E	R	M	L	A	A	Q	G	V
Template Known Secondary structure		S	S		S	S	S				S												T	T		.	S																			T	T	S	S	S	S														S	S													T	T
Template Predicted Secondary structure																										.
Template SS confidence
		274	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.		.	.	300	.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.
		323	.	.	.	.	.									.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.
Predicted Secondary structure								.	.	.	.	.	.	.	.
Query SS confidence								.	.	.	.	.	.	.	.
Query Sequence		P	T	D	F	V	E	.	.	.	.	.	.	.	.	N	Y	A	K	Y	L	P	T	A	M	L	T	K	A	V	Y	A	D	T	E	G	F	V	S	E	M	D	T	R	A	L	G	M	A	V	V	A	M	G	G	G	R	R	Q	A	S	D	T	I	D	Y	S	V	G	F	T	D	M	A	R	L	G	D	Q	V	D
Query Conservation								.	.	.	.	.	.	.	.
Alig confidence								.	.	.	.	.	.	.	.
Template Conservation
Template Sequence		D	P	G	L	A	R	A	L	C	S	G	S	P	A	E	R	R	Q	L	L	P	R	A	R	E	Q	E	E	L	L	A	P	A	D	G	T	V	E	L	V	R	A	L	P	L	A	L	V	L	H	E	L	G	A	G	R	S	R	A	G	E	P	L	R	L	G	V	G	A	E	L	L	V	D	V	G	Q	R	L	R
Template Known Secondary structure												S									S				S								S	S	S																		T	T	T	S		S	S	T	T					T	T							S		T	T
Template Predicted Secondary structure
Template SS confidence
		353	.	.	.	.	.	.	360	.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.
		395	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420	.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.
Predicted Secondary structure
Query SS confidence
Query Sequence		G	Q	R	P	L	A	V	I	H	A	K	D	E	N	N	W	Q	E	A	A	K	A	V	K	A	A	I	K	L	A	D	K	A	P	E	S	T	P	T	V	Y	R	R	I
Query Conservation
Alig confidence
Template Conservation
Template Sequence		R	G	T	P	W	L	R	V	H	R	D	G	P	A	L	S	G	P	Q	S	R	A	L	Q	E	A	L	V	L	S	D	R	A	P	F	A	A	P	L	P	F	A	E	L
Template Known Secondary structure		T	T									S	S	S												T	T					S	S
Template Predicted Secondary structure
Template SS confidence
		433	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.